FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE4021, 209 aa 1>>>pF1KE4021 209 - 209 aa - 209 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.2683+/-0.000337; mu= 16.7959+/- 0.021 mean_var=172.0274+/-37.304, 0's: 0 Z-trim(119.5): 219 B-trim: 6 in 1/52 Lambda= 0.097786 statistics sampled from 33406 (33686) to 33406 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.76), E-opt: 0.2 (0.395), width: 16 Scan time: 6.260 The best scores are: opt bits E(85289) NP_742013 (OMIM: 605700) E3 ubiquitin-protein liga ( 488) 504 82.9 9.4e-16 NP_067076 (OMIM: 605700) E3 ubiquitin-protein liga ( 518) 504 83.0 9.7e-16 XP_011542587 (OMIM: 607868) PREDICTED: E3 ubiquiti ( 391) 354 61.6 2e-09 XP_016857901 (OMIM: 607868) PREDICTED: E3 ubiquiti ( 467) 354 61.8 2.1e-09 NP_660215 (OMIM: 607868) E3 ubiquitin-protein liga ( 468) 354 61.8 2.1e-09 XP_011512568 (OMIM: 609316) PREDICTED: E3 ubiquiti ( 261) 349 60.6 2.6e-09 XP_011513161 (OMIM: 600830) PREDICTED: tripartite ( 462) 351 61.3 2.9e-09 XP_016866752 (OMIM: 600830) PREDICTED: tripartite ( 462) 351 61.3 2.9e-09 XP_005249432 (OMIM: 600830) PREDICTED: tripartite ( 539) 351 61.4 3.1e-09 NP_003440 (OMIM: 600830) tripartite motif-containi ( 539) 351 61.4 3.1e-09 XP_005249431 (OMIM: 600830) PREDICTED: tripartite ( 539) 351 61.4 3.1e-09 XP_005249435 (OMIM: 600830) PREDICTED: tripartite ( 539) 351 61.4 3.1e-09 XP_005249433 (OMIM: 600830) PREDICTED: tripartite ( 539) 351 61.4 3.1e-09 XP_006715243 (OMIM: 600830) PREDICTED: tripartite ( 539) 351 61.4 3.1e-09 XP_005249434 (OMIM: 600830) PREDICTED: tripartite ( 539) 351 61.4 3.1e-09 NP_001229712 (OMIM: 600830) tripartite motif-conta ( 539) 351 61.4 3.1e-09 XP_011512567 (OMIM: 609316) PREDICTED: E3 ubiquiti ( 421) 349 61.0 3.3e-09 XP_011512566 (OMIM: 609316) PREDICTED: E3 ubiquiti ( 424) 349 61.0 3.3e-09 NP_008959 (OMIM: 609316) E3 ubiquitin-protein liga ( 425) 349 61.0 3.3e-09 NP_006501 (OMIM: 602165) zinc finger protein RFP [ ( 513) 343 60.3 6.6e-09 XP_016856908 (OMIM: 606123) PREDICTED: E3 ubiquiti ( 262) 334 58.5 1.1e-08 XP_016856907 (OMIM: 606123) PREDICTED: E3 ubiquiti ( 262) 334 58.5 1.1e-08 NP_001128327 (OMIM: 606123) E3 ubiquitin-protein l ( 343) 334 58.7 1.3e-08 NP_439893 (OMIM: 605701) tripartite motif-containi ( 395) 334 58.8 1.4e-08 XP_006711842 (OMIM: 606123) PREDICTED: E3 ubiquiti ( 477) 334 58.9 1.5e-08 XP_011542512 (OMIM: 606123) PREDICTED: E3 ubiquiti ( 477) 334 58.9 1.5e-08 NP_001020111 (OMIM: 606123) E3 ubiquitin-protein l ( 477) 334 58.9 1.5e-08 XP_011542511 (OMIM: 606123) PREDICTED: E3 ubiquiti ( 477) 334 58.9 1.5e-08 NP_057186 (OMIM: 606123) E3 ubiquitin-protein liga ( 477) 334 58.9 1.5e-08 NP_006769 (OMIM: 605701) tripartite motif-containi ( 481) 334 58.9 1.5e-08 NP_060543 (OMIM: 613184) E3 ubiquitin-protein liga ( 485) 333 58.8 1.7e-08 XP_016873516 (OMIM: 606124) PREDICTED: tripartite ( 375) 327 57.8 2.7e-08 NP_065091 (OMIM: 606124) tripartite motif-containi ( 452) 327 57.9 3e-08 XP_011514089 (OMIM: 612548) PREDICTED: E3 ubiquiti ( 304) 323 57.1 3.6e-08 NP_001268379 (OMIM: 612548) E3 ubiquitin-protein l ( 486) 323 57.4 4.5e-08 XP_011514091 (OMIM: 612548) PREDICTED: E3 ubiquiti ( 486) 323 57.4 4.5e-08 NP_835226 (OMIM: 612548) E3 ubiquitin-protein liga ( 487) 323 57.4 4.5e-08 NP_001268380 (OMIM: 612548) E3 ubiquitin-protein l ( 487) 323 57.4 4.5e-08 NP_003132 (OMIM: 109092) E3 ubiquitin-protein liga ( 475) 314 56.1 1.1e-07 NP_477514 (OMIM: 607564) tripartite motif-containi ( 488) 313 56.0 1.2e-07 NP_001003818 (OMIM: 607564) tripartite motif-conta ( 516) 313 56.0 1.2e-07 NP_944606 (OMIM: 612549) tripartite motif-containi ( 250) 306 54.5 1.7e-07 XP_011514491 (OMIM: 612550) PREDICTED: tripartite ( 249) 303 54.1 2.3e-07 XP_011514489 (OMIM: 612550) PREDICTED: tripartite ( 250) 303 54.1 2.3e-07 NP_001304744 (OMIM: 612550) tripartite motif-conta ( 250) 303 54.1 2.3e-07 NP_942150 (OMIM: 612550) tripartite motif-containi ( 250) 303 54.1 2.3e-07 XP_005273509 (OMIM: 617007) PREDICTED: tripartite ( 298) 302 54.1 2.8e-07 NP_741983 (OMIM: 617007) tripartite motif-containi ( 493) 302 54.5 3.6e-07 NP_001186502 (OMIM: 606559) E3 ubiquitin-protein l ( 494) 301 54.3 3.9e-07 NP_006065 (OMIM: 606559) E3 ubiquitin-protein liga ( 498) 301 54.3 4e-07 >>NP_742013 (OMIM: 605700) E3 ubiquitin-protein ligase T (488 aa) initn: 361 init1: 326 opt: 504 Z-score: 403.8 bits: 82.9 E(85289): 9.4e-16 Smith-Waterman score: 504; 42.2% identity (71.1% similar) in 173 aa overlap (6-178:19-188) 10 20 30 40 pF1KE4 MEFVTALADLRAEASCPICLDYLKDPVTISCGHNFCLSCIIMSWKDL :: .:..:::: .::.:::.:: : :::::: .:: :.:: NP_742 MAETSLLEAGASAASTAAALENLQVEASCSVCLEYLKEPVIIECGHNFCKACITRWWEDL 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE4 HDSFPCPFCHFCCPERKFISNPQLGSLTEIAKQLQIRSKKRKRQEEKHVCKKHNQVLTFF . .:::: :. :.. : ::::..::::::: . ::: ..:. .: .:...:..: NP_742 ERDFPCPVCRKTSRYRSLRPNRQLGSMVEIAKQLQ--AVKRKIRDES-LCPQHHEALSLF 70 80 90 100 110 110 120 130 140 150 160 pF1KE4 CQKDLELLCPRCSLSTDHQHHCVWPIKKAASYHRKKLEEYNAPWKERVELIEKVITMQTR : .: : .: :..: :. : : :. :.. ...::.. : ..... : . . . . NP_742 CYEDQEAVCLICAISHTHRAHTVVPLDDATQEYKEKLQKCLEPLEQKLQEITRCKSSEEK 120 130 140 150 160 170 170 180 190 200 pF1KE4 KSLELKKKMESPSVTRLECSCTISAHFNLRLPGSSDSSASGS : :::. .:: NP_742 KPGELKRLVESRRQQILREFEELHRRLDEEQQVLLSRLEEEEQDILQRLRENAAHLGDKR 180 190 200 210 220 230 >>NP_067076 (OMIM: 605700) E3 ubiquitin-protein ligase T (518 aa) initn: 382 init1: 326 opt: 504 Z-score: 403.6 bits: 83.0 E(85289): 9.7e-16 Smith-Waterman score: 504; 42.2% identity (71.1% similar) in 173 aa overlap (6-178:19-188) 10 20 30 40 pF1KE4 MEFVTALADLRAEASCPICLDYLKDPVTISCGHNFCLSCIIMSWKDL :: .:..:::: .::.:::.:: : :::::: .:: :.:: NP_067 MAETSLLEAGASAASTAAALENLQVEASCSVCLEYLKEPVIIECGHNFCKACITRWWEDL 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE4 HDSFPCPFCHFCCPERKFISNPQLGSLTEIAKQLQIRSKKRKRQEEKHVCKKHNQVLTFF . .:::: :. :.. : ::::..::::::: . ::: ..:. .: .:...:..: NP_067 ERDFPCPVCRKTSRYRSLRPNRQLGSMVEIAKQLQ--AVKRKIRDES-LCPQHHEALSLF 70 80 90 100 110 110 120 130 140 150 160 pF1KE4 CQKDLELLCPRCSLSTDHQHHCVWPIKKAASYHRKKLEEYNAPWKERVELIEKVITMQTR : .: : .: :..: :. : : :. :.. ...::.. : ..... : . . . . NP_067 CYEDQEAVCLICAISHTHRAHTVVPLDDATQEYKEKLQKCLEPLEQKLQEITRCKSSEEK 120 130 140 150 160 170 170 180 190 200 pF1KE4 KSLELKKKMESPSVTRLECSCTISAHFNLRLPGSSDSSASGS : :::. .:: NP_067 KPGELKRLVESRRQQILREFEELHRRLDEEQQVLLSRLEEEEQDILQRLRENAAHLGDKR 180 190 200 210 220 230 >>XP_011542587 (OMIM: 607868) PREDICTED: E3 ubiquitin-pr (391 aa) initn: 366 init1: 244 opt: 354 Z-score: 290.4 bits: 61.6 E(85289): 2e-09 Smith-Waterman score: 354; 38.4% identity (60.1% similar) in 138 aa overlap (9-146:9-141) 10 20 30 40 50 60 pF1KE4 MEFVTALADLRAEASCPICLDYLKDPVTISCGHNFCLSCIIMSWKDLHDSFPCPFCHFCC .:. ::.: :::::. ::: .:::::: :: : . . . :: :. XP_011 MAAPDLSTNLQEEATCAICLDYFTDPVMTDCGHNFCRECIRRCWGQPEGPYACPECRELS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 PERKFISNPQLGSLTEIAKQLQIRSKKRKRQEEKHVCKKHNQVLTFFCQKDLELLCPRCS :.:.. : :....:.:..:. : . :: : . :. :: .:.::: : XP_011 PQRNLRPNRPLAKMAEMARRLHPPSPV-----PQGVCPAHREPLAAFCGDELRLLCAACE 70 80 90 100 110 130 140 150 160 170 180 pF1KE4 LSTDHQHHCVWPIKKAASYHRKKLEEYNAPWKERVELIEKVITMQTRKSLELKKKMESPS : .: : : :.. :: . :::. XP_011 RSGEHWAHRVRPLQDAAEDLKAKLEKSLEHLRKQMQDALLFQAQADETCVLWQDIKDALR 120 130 140 150 160 170 >>XP_016857901 (OMIM: 607868) PREDICTED: E3 ubiquitin-pr (467 aa) initn: 366 init1: 244 opt: 354 Z-score: 289.7 bits: 61.8 E(85289): 2.1e-09 Smith-Waterman score: 354; 38.4% identity (60.1% similar) in 138 aa overlap (9-146:9-141) 10 20 30 40 50 60 pF1KE4 MEFVTALADLRAEASCPICLDYLKDPVTISCGHNFCLSCIIMSWKDLHDSFPCPFCHFCC .:. ::.: :::::. ::: .:::::: :: : . . . :: :. XP_016 MAAPDLSTNLQEEATCAICLDYFTDPVMTDCGHNFCRECIRRCWGQPEGPYACPECRELS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 PERKFISNPQLGSLTEIAKQLQIRSKKRKRQEEKHVCKKHNQVLTFFCQKDLELLCPRCS :.:.. : :....:.:..:. : . :: : . :. :: .:.::: : XP_016 PQRNLRPNRPLAKMAEMARRLHPPSPV-----PQGVCPAHREPLAAFCGDELRLLCAACE 70 80 90 100 110 130 140 150 160 170 180 pF1KE4 LSTDHQHHCVWPIKKAASYHRKKLEEYNAPWKERVELIEKVITMQTRKSLELKKKMESPS : .: : : :.. :: . :::. XP_016 RSGEHWAHRVRPLQDAAEDLKAKLEKSLEHLRKQMQDALLFQAQADETCVLWQMVESQRQ 120 130 140 150 160 170 >>NP_660215 (OMIM: 607868) E3 ubiquitin-protein ligase T (468 aa) initn: 316 init1: 194 opt: 354 Z-score: 289.6 bits: 61.8 E(85289): 2.1e-09 Smith-Waterman score: 354; 38.4% identity (60.1% similar) in 138 aa overlap (9-146:9-141) 10 20 30 40 50 60 pF1KE4 MEFVTALADLRAEASCPICLDYLKDPVTISCGHNFCLSCIIMSWKDLHDSFPCPFCHFCC .:. ::.: :::::. ::: .:::::: :: : . . . :: :. NP_660 MAAPDLSTNLQEEATCAICLDYFTDPVMTDCGHNFCRECIRRCWGQPEGPYACPECRELS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 PERKFISNPQLGSLTEIAKQLQIRSKKRKRQEEKHVCKKHNQVLTFFCQKDLELLCPRCS :.:.. : :....:.:..:. : . :: : . :. :: .:.::: : NP_660 PQRNLRPNRPLAKMAEMARRLHPPSPV-----PQGVCPAHREPLAAFCGDELRLLCAACE 70 80 90 100 110 130 140 150 160 170 180 pF1KE4 LSTDHQHHCVWPIKKAASYHRKKLEEYNAPWKERVELIEKVITMQTRKSLELKKKMESPS : .: : : :.. :: . :::. NP_660 RSGEHWAHRVRPLQDAAEDLKAKLEKSLEHLRKQMQDALLFQAQADETCVLWQKMVESQR 120 130 140 150 160 170 >>XP_011512568 (OMIM: 609316) PREDICTED: E3 ubiquitin-pr (261 aa) initn: 319 init1: 229 opt: 349 Z-score: 288.2 bits: 60.6 E(85289): 2.6e-09 Smith-Waterman score: 349; 38.0% identity (63.5% similar) in 137 aa overlap (10-146:10-144) 10 20 30 40 50 60 pF1KE4 MEFVTALADLRAEASCPICLDYLKDPVTISCGHNFCLSCIIMSWKDLHDSFPCPFCHFCC :. :. :::::: :. ::::.:::::::.:: . . : ::.:. XP_011 MASGQFVNKLQEEVICPICLDILQKPVTIDCGHNFCLKCITQIGETSCGFFKCPLCKTSV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 PERKFISNPQLGSLTEIAKQLQIRSKKRKRQEEKHVCKKHNQVLTFFCQKDLELLCPRCS . . : : .:.: . :: . ::.: .: .:.... .::. : ..:: : XP_011 RKNAIRFNSLLRNLVEKIQALQASEVQSKRKEA--TCPRHQEMFHYFCEDDGKFLCFVCR 70 80 90 100 110 130 140 150 160 170 180 pF1KE4 LSTDHQHHCVWPIKKAASYHRKKLEEYNAPWKERVELIEKVITMQTRKSLELKKKMESPS : ::. : : :..::. .. ...: XP_011 ESKDHKSHNVSLIEEAAQNYQGQIQEQIQVLQQKEKETVQVKAQGVHRVDVFTDQVEHEK 120 130 140 150 160 170 >>XP_011513161 (OMIM: 600830) PREDICTED: tripartite moti (462 aa) initn: 251 init1: 179 opt: 351 Z-score: 287.4 bits: 61.3 E(85289): 2.9e-09 Smith-Waterman score: 351; 36.8% identity (65.1% similar) in 152 aa overlap (1-144:1-149) 10 20 30 40 50 pF1KE4 MEFVTALADLRAEASCPICLDYLKDPVTISCGHNFCLSCIIMSWKDLHDSFP-CPFCHFC : . : .:. :..: ::::::.:::::.::: :: :: . . . : : ::.:. XP_011 MATSAPLRSLEEEVTCSICLDYLRDPVTIDCGHVFCRSCTT-DVRPISGSRPVCPLCK-- 10 20 30 40 50 60 70 80 90 100 110 pF1KE4 CPERKFISNP--QLGSLTEIAKQLQIRSKKR-----KRQEEKHVCKKHNQVLTFFCQKDL : .: : ::.::.: ..:.. . .. ..:.. ..:..: . : ..:. : XP_011 KPFKKENIRPVWQLASLVENIERLKVDKGRQPGEVTREQQDAKLCERHREKLHYYCEDDG 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE4 ELLCPRCSLSTDHQHHCVWPIKKAASYHRKKLEEYNAPWKERVELIEKVITMQTRKSLEL .::: : : .:. : . ..:::. ::.:. XP_011 KLLCVMCRESREHRPHTAVLMEKAAQPHREKILNHLSTLRRDRDKIQGFQAKGEADILAA 120 130 140 150 160 170 180 190 200 pF1KE4 KKKMESPSVTRLECSCTISAHFNLRLPGSSDSSASGS XP_011 LDTRDFLNRYPRKKFWVGKPIARVVKKKTGEFSDKLLSLQRGLREFQGKLLRDLEYKTVS 180 190 200 210 220 230 >>XP_016866752 (OMIM: 600830) PREDICTED: tripartite moti (462 aa) initn: 251 init1: 179 opt: 351 Z-score: 287.4 bits: 61.3 E(85289): 2.9e-09 Smith-Waterman score: 351; 36.8% identity (65.1% similar) in 152 aa overlap (1-144:1-149) 10 20 30 40 50 pF1KE4 MEFVTALADLRAEASCPICLDYLKDPVTISCGHNFCLSCIIMSWKDLHDSFP-CPFCHFC : . : .:. :..: ::::::.:::::.::: :: :: . . . : : ::.:. XP_016 MATSAPLRSLEEEVTCSICLDYLRDPVTIDCGHVFCRSCTT-DVRPISGSRPVCPLCK-- 10 20 30 40 50 60 70 80 90 100 110 pF1KE4 CPERKFISNP--QLGSLTEIAKQLQIRSKKR-----KRQEEKHVCKKHNQVLTFFCQKDL : .: : ::.::.: ..:.. . .. ..:.. ..:..: . : ..:. : XP_016 KPFKKENIRPVWQLASLVENIERLKVDKGRQPGEVTREQQDAKLCERHREKLHYYCEDDG 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE4 ELLCPRCSLSTDHQHHCVWPIKKAASYHRKKLEEYNAPWKERVELIEKVITMQTRKSLEL .::: : : .:. : . ..:::. ::.:. XP_016 KLLCVMCRESREHRPHTAVLMEKAAQPHREKILNHLSTLRRDRDKIQGFQAKGEADILAA 120 130 140 150 160 170 180 190 200 pF1KE4 KKKMESPSVTRLECSCTISAHFNLRLPGSSDSSASGS XP_016 LDTRDFLNRYPRKKFWVGKPIARVVKKKTGEFSDKLLSLQRGLREFQGKLLRDLEYKTVS 180 190 200 210 220 230 >>XP_005249432 (OMIM: 600830) PREDICTED: tripartite moti (539 aa) initn: 320 init1: 179 opt: 351 Z-score: 286.8 bits: 61.4 E(85289): 3.1e-09 Smith-Waterman score: 351; 36.8% identity (65.1% similar) in 152 aa overlap (1-144:1-149) 10 20 30 40 50 pF1KE4 MEFVTALADLRAEASCPICLDYLKDPVTISCGHNFCLSCIIMSWKDLHDSFP-CPFCHFC : . : .:. :..: ::::::.:::::.::: :: :: . . . : : ::.:. XP_005 MATSAPLRSLEEEVTCSICLDYLRDPVTIDCGHVFCRSCTT-DVRPISGSRPVCPLCK-- 10 20 30 40 50 60 70 80 90 100 110 pF1KE4 CPERKFISNP--QLGSLTEIAKQLQIRSKKR-----KRQEEKHVCKKHNQVLTFFCQKDL : .: : ::.::.: ..:.. . .. ..:.. ..:..: . : ..:. : XP_005 KPFKKENIRPVWQLASLVENIERLKVDKGRQPGEVTREQQDAKLCERHREKLHYYCEDDG 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE4 ELLCPRCSLSTDHQHHCVWPIKKAASYHRKKLEEYNAPWKERVELIEKVITMQTRKSLEL .::: : : .:. : . ..:::. ::.:. XP_005 KLLCVMCRESREHRPHTAVLMEKAAQPHREKILNHLSTLRRDRDKIQGFQAKGEADILAA 120 130 140 150 160 170 180 190 200 pF1KE4 KKKMESPSVTRLECSCTISAHFNLRLPGSSDSSASGS XP_005 LKKLQDQRQYIVAEFEQGHQFLREREEHLLEQLAKLEQELTEGREKFKSRGVGELARLAL 180 190 200 210 220 230 >>NP_003440 (OMIM: 600830) tripartite motif-containing p (539 aa) initn: 320 init1: 179 opt: 351 Z-score: 286.8 bits: 61.4 E(85289): 3.1e-09 Smith-Waterman score: 351; 36.8% identity (65.1% similar) in 152 aa overlap (1-144:1-149) 10 20 30 40 50 pF1KE4 MEFVTALADLRAEASCPICLDYLKDPVTISCGHNFCLSCIIMSWKDLHDSFP-CPFCHFC : . : .:. :..: ::::::.:::::.::: :: :: . . . : : ::.:. NP_003 MATSAPLRSLEEEVTCSICLDYLRDPVTIDCGHVFCRSCTT-DVRPISGSRPVCPLCK-- 10 20 30 40 50 60 70 80 90 100 110 pF1KE4 CPERKFISNP--QLGSLTEIAKQLQIRSKKR-----KRQEEKHVCKKHNQVLTFFCQKDL : .: : ::.::.: ..:.. . .. ..:.. ..:..: . : ..:. : NP_003 KPFKKENIRPVWQLASLVENIERLKVDKGRQPGEVTREQQDAKLCERHREKLHYYCEDDG 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE4 ELLCPRCSLSTDHQHHCVWPIKKAASYHRKKLEEYNAPWKERVELIEKVITMQTRKSLEL .::: : : .:. : . ..:::. ::.:. NP_003 KLLCVMCRESREHRPHTAVLMEKAAQPHREKILNHLSTLRRDRDKIQGFQAKGEADILAA 120 130 140 150 160 170 180 190 200 pF1KE4 KKKMESPSVTRLECSCTISAHFNLRLPGSSDSSASGS NP_003 LKKLQDQRQYIVAEFEQGHQFLREREEHLLEQLAKLEQELTEGREKFKSRGVGELARLAL 180 190 200 210 220 230 209 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 22:43:24 2016 done: Sat Nov 5 22:43:25 2016 Total Scan time: 6.260 Total Display time: 0.010 Function used was FASTA [36.3.4 Apr, 2011]