FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE6467, 515 aa 1>>>pF1KE6467 515 - 515 aa - 515 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.9434+/-0.000397; mu= 19.8644+/- 0.025 mean_var=60.7523+/-12.992, 0's: 0 Z-trim(111.3): 25 B-trim: 1285 in 1/54 Lambda= 0.164548 statistics sampled from 19786 (19803) to 19786 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.588), E-opt: 0.2 (0.232), width: 16 Scan time: 5.950 The best scores are: opt bits E(85289) NP_631912 (OMIM: 611527) sodium/hydrogen exchanger ( 515) 3346 803.2 0 XP_006714156 (OMIM: 611527) PREDICTED: sodium/hydr ( 515) 3337 801.1 0 XP_011529925 (OMIM: 611527) PREDICTED: sodium/hydr ( 515) 3337 801.1 0 XP_011529924 (OMIM: 611527) PREDICTED: sodium/hydr ( 515) 3337 801.1 0 NP_001094344 (OMIM: 611527) sodium/hydrogen exchan ( 475) 2893 695.7 8e-200 XP_006714148 (OMIM: 611789) PREDICTED: mitochondri ( 537) 1887 456.9 6.9e-128 NP_849155 (OMIM: 611789) mitochondrial sodium/hydr ( 537) 1887 456.9 6.9e-128 NP_001287683 (OMIM: 611789) mitochondrial sodium/h ( 480) 1570 381.6 2.8e-105 XP_006714149 (OMIM: 611789) PREDICTED: mitochondri ( 480) 1570 381.6 2.8e-105 NP_001287685 (OMIM: 611789) mitochondrial sodium/h ( 417) 1171 286.8 8.2e-77 >>NP_631912 (OMIM: 611527) sodium/hydrogen exchanger 9B1 (515 aa) initn: 3346 init1: 3346 opt: 3346 Z-score: 4289.1 bits: 803.2 E(85289): 0 Smith-Waterman score: 3346; 100.0% identity (100.0% similar) in 515 aa overlap (1-515:1-515) 10 20 30 40 50 60 pF1KE6 MHTTESKNEHLEDENFQTSTTPQSLIDPNNTAHEETKTVLSDTEEIKPQTKKETYISCPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_631 MHTTESKNEHLEDENFQTSTTPQSLIDPNNTAHEETKTVLSDTEEIKPQTKKETYISCPL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 RGVLNVIITNGVILFVIWCMTWSILGSEALPGGNLFGLFIIFYSAIIGGKILQLIRIPLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_631 RGVLNVIITNGVILFVIWCMTWSILGSEALPGGNLFGLFIIFYSAIIGGKILQLIRIPLV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 PPLPPLLGMLLAGFTIRNVPFINEHVHVPNTWSSILRSIALTIILIRAGLGLDPQALRHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_631 PPLPPLLGMLLAGFTIRNVPFINEHVHVPNTWSSILRSIALTIILIRAGLGLDPQALRHL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 KVVCFRLAVGPCLMEASAAAVFSHFIMKFPWQWAFLLGFVLGAVSPAVVVPYMMVLQENG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_631 KVVCFRLAVGPCLMEASAAAVFSHFIMKFPWQWAFLLGFVLGAVSPAVVVPYMMVLQENG 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE6 YGVEEGIPTLLMAASSMDDILAITGFNTCLSIVFSSGGILNNAIASIRNVCISLLAGIVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_631 YGVEEGIPTLLMAASSMDDILAITGFNTCLSIVFSSGGILNNAIASIRNVCISLLAGIVL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE6 GFFVRYFPSEDQKKLTLKRGFLVLTMCVSAVLGSQRIGLHGSGGLCTLVLSFIAGTKWSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_631 GFFVRYFPSEDQKKLTLKRGFLVLTMCVSAVLGSQRIGLHGSGGLCTLVLSFIAGTKWSQ 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE6 EKMKVQKIITTVWDIFQPLLFGLVGAEVSVSSLESNIVGISVATLSLALCVRILTTYLLM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_631 EKMKVQKIITTVWDIFQPLLFGLVGAEVSVSSLESNIVGISVATLSLALCVRILTTYLLM 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE6 CFAGFSFKEKIFIALAWMPKATVQAVLGPLALETARVSAPHLEPYAKDVMTVAFLAILIT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_631 CFAGFSFKEKIFIALAWMPKATVQAVLGPLALETARVSAPHLEPYAKDVMTVAFLAILIT 430 440 450 460 470 480 490 500 510 pF1KE6 APNGALLMGILGPKMLTRHYDPSKIKLQLSTLEHH ::::::::::::::::::::::::::::::::::: NP_631 APNGALLMGILGPKMLTRHYDPSKIKLQLSTLEHH 490 500 510 >>XP_006714156 (OMIM: 611527) PREDICTED: sodium/hydrogen (515 aa) initn: 3337 init1: 3337 opt: 3337 Z-score: 4277.6 bits: 801.1 E(85289): 0 Smith-Waterman score: 3337; 99.8% identity (100.0% similar) in 515 aa overlap (1-515:1-515) 10 20 30 40 50 60 pF1KE6 MHTTESKNEHLEDENFQTSTTPQSLIDPNNTAHEETKTVLSDTEEIKPQTKKETYISCPL ::::::::::::::::::::::::::::::::.::::::::::::::::::::::::::: XP_006 MHTTESKNEHLEDENFQTSTTPQSLIDPNNTAQEETKTVLSDTEEIKPQTKKETYISCPL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 RGVLNVIITNGVILFVIWCMTWSILGSEALPGGNLFGLFIIFYSAIIGGKILQLIRIPLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 RGVLNVIITNGVILFVIWCMTWSILGSEALPGGNLFGLFIIFYSAIIGGKILQLIRIPLV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 PPLPPLLGMLLAGFTIRNVPFINEHVHVPNTWSSILRSIALTIILIRAGLGLDPQALRHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 PPLPPLLGMLLAGFTIRNVPFINEHVHVPNTWSSILRSIALTIILIRAGLGLDPQALRHL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 KVVCFRLAVGPCLMEASAAAVFSHFIMKFPWQWAFLLGFVLGAVSPAVVVPYMMVLQENG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 KVVCFRLAVGPCLMEASAAAVFSHFIMKFPWQWAFLLGFVLGAVSPAVVVPYMMVLQENG 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE6 YGVEEGIPTLLMAASSMDDILAITGFNTCLSIVFSSGGILNNAIASIRNVCISLLAGIVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 YGVEEGIPTLLMAASSMDDILAITGFNTCLSIVFSSGGILNNAIASIRNVCISLLAGIVL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE6 GFFVRYFPSEDQKKLTLKRGFLVLTMCVSAVLGSQRIGLHGSGGLCTLVLSFIAGTKWSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GFFVRYFPSEDQKKLTLKRGFLVLTMCVSAVLGSQRIGLHGSGGLCTLVLSFIAGTKWSQ 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE6 EKMKVQKIITTVWDIFQPLLFGLVGAEVSVSSLESNIVGISVATLSLALCVRILTTYLLM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 EKMKVQKIITTVWDIFQPLLFGLVGAEVSVSSLESNIVGISVATLSLALCVRILTTYLLM 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE6 CFAGFSFKEKIFIALAWMPKATVQAVLGPLALETARVSAPHLEPYAKDVMTVAFLAILIT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 CFAGFSFKEKIFIALAWMPKATVQAVLGPLALETARVSAPHLEPYAKDVMTVAFLAILIT 430 440 450 460 470 480 490 500 510 pF1KE6 APNGALLMGILGPKMLTRHYDPSKIKLQLSTLEHH ::::::::::::::::::::::::::::::::::: XP_006 APNGALLMGILGPKMLTRHYDPSKIKLQLSTLEHH 490 500 510 >>XP_011529925 (OMIM: 611527) PREDICTED: sodium/hydrogen (515 aa) initn: 3337 init1: 3337 opt: 3337 Z-score: 4277.6 bits: 801.1 E(85289): 0 Smith-Waterman score: 3337; 99.8% identity (100.0% similar) in 515 aa overlap (1-515:1-515) 10 20 30 40 50 60 pF1KE6 MHTTESKNEHLEDENFQTSTTPQSLIDPNNTAHEETKTVLSDTEEIKPQTKKETYISCPL ::::::::::::::::::::::::::::::::.::::::::::::::::::::::::::: XP_011 MHTTESKNEHLEDENFQTSTTPQSLIDPNNTAQEETKTVLSDTEEIKPQTKKETYISCPL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 RGVLNVIITNGVILFVIWCMTWSILGSEALPGGNLFGLFIIFYSAIIGGKILQLIRIPLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RGVLNVIITNGVILFVIWCMTWSILGSEALPGGNLFGLFIIFYSAIIGGKILQLIRIPLV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 PPLPPLLGMLLAGFTIRNVPFINEHVHVPNTWSSILRSIALTIILIRAGLGLDPQALRHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PPLPPLLGMLLAGFTIRNVPFINEHVHVPNTWSSILRSIALTIILIRAGLGLDPQALRHL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 KVVCFRLAVGPCLMEASAAAVFSHFIMKFPWQWAFLLGFVLGAVSPAVVVPYMMVLQENG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KVVCFRLAVGPCLMEASAAAVFSHFIMKFPWQWAFLLGFVLGAVSPAVVVPYMMVLQENG 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE6 YGVEEGIPTLLMAASSMDDILAITGFNTCLSIVFSSGGILNNAIASIRNVCISLLAGIVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YGVEEGIPTLLMAASSMDDILAITGFNTCLSIVFSSGGILNNAIASIRNVCISLLAGIVL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE6 GFFVRYFPSEDQKKLTLKRGFLVLTMCVSAVLGSQRIGLHGSGGLCTLVLSFIAGTKWSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GFFVRYFPSEDQKKLTLKRGFLVLTMCVSAVLGSQRIGLHGSGGLCTLVLSFIAGTKWSQ 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE6 EKMKVQKIITTVWDIFQPLLFGLVGAEVSVSSLESNIVGISVATLSLALCVRILTTYLLM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EKMKVQKIITTVWDIFQPLLFGLVGAEVSVSSLESNIVGISVATLSLALCVRILTTYLLM 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE6 CFAGFSFKEKIFIALAWMPKATVQAVLGPLALETARVSAPHLEPYAKDVMTVAFLAILIT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CFAGFSFKEKIFIALAWMPKATVQAVLGPLALETARVSAPHLEPYAKDVMTVAFLAILIT 430 440 450 460 470 480 490 500 510 pF1KE6 APNGALLMGILGPKMLTRHYDPSKIKLQLSTLEHH ::::::::::::::::::::::::::::::::::: XP_011 APNGALLMGILGPKMLTRHYDPSKIKLQLSTLEHH 490 500 510 >>XP_011529924 (OMIM: 611527) PREDICTED: sodium/hydrogen (515 aa) initn: 3337 init1: 3337 opt: 3337 Z-score: 4277.6 bits: 801.1 E(85289): 0 Smith-Waterman score: 3337; 99.8% identity (100.0% similar) in 515 aa overlap (1-515:1-515) 10 20 30 40 50 60 pF1KE6 MHTTESKNEHLEDENFQTSTTPQSLIDPNNTAHEETKTVLSDTEEIKPQTKKETYISCPL ::::::::::::::::::::::::::::::::.::::::::::::::::::::::::::: XP_011 MHTTESKNEHLEDENFQTSTTPQSLIDPNNTAQEETKTVLSDTEEIKPQTKKETYISCPL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 RGVLNVIITNGVILFVIWCMTWSILGSEALPGGNLFGLFIIFYSAIIGGKILQLIRIPLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RGVLNVIITNGVILFVIWCMTWSILGSEALPGGNLFGLFIIFYSAIIGGKILQLIRIPLV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 PPLPPLLGMLLAGFTIRNVPFINEHVHVPNTWSSILRSIALTIILIRAGLGLDPQALRHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PPLPPLLGMLLAGFTIRNVPFINEHVHVPNTWSSILRSIALTIILIRAGLGLDPQALRHL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 KVVCFRLAVGPCLMEASAAAVFSHFIMKFPWQWAFLLGFVLGAVSPAVVVPYMMVLQENG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KVVCFRLAVGPCLMEASAAAVFSHFIMKFPWQWAFLLGFVLGAVSPAVVVPYMMVLQENG 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE6 YGVEEGIPTLLMAASSMDDILAITGFNTCLSIVFSSGGILNNAIASIRNVCISLLAGIVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YGVEEGIPTLLMAASSMDDILAITGFNTCLSIVFSSGGILNNAIASIRNVCISLLAGIVL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE6 GFFVRYFPSEDQKKLTLKRGFLVLTMCVSAVLGSQRIGLHGSGGLCTLVLSFIAGTKWSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GFFVRYFPSEDQKKLTLKRGFLVLTMCVSAVLGSQRIGLHGSGGLCTLVLSFIAGTKWSQ 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE6 EKMKVQKIITTVWDIFQPLLFGLVGAEVSVSSLESNIVGISVATLSLALCVRILTTYLLM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EKMKVQKIITTVWDIFQPLLFGLVGAEVSVSSLESNIVGISVATLSLALCVRILTTYLLM 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE6 CFAGFSFKEKIFIALAWMPKATVQAVLGPLALETARVSAPHLEPYAKDVMTVAFLAILIT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CFAGFSFKEKIFIALAWMPKATVQAVLGPLALETARVSAPHLEPYAKDVMTVAFLAILIT 430 440 450 460 470 480 490 500 510 pF1KE6 APNGALLMGILGPKMLTRHYDPSKIKLQLSTLEHH ::::::::::::::::::::::::::::::::::: XP_011 APNGALLMGILGPKMLTRHYDPSKIKLQLSTLEHH 490 500 510 >>NP_001094344 (OMIM: 611527) sodium/hydrogen exchanger (475 aa) initn: 2893 init1: 2893 opt: 2893 Z-score: 3708.5 bits: 695.7 E(85289): 8e-200 Smith-Waterman score: 2893; 100.0% identity (100.0% similar) in 444 aa overlap (1-444:1-444) 10 20 30 40 50 60 pF1KE6 MHTTESKNEHLEDENFQTSTTPQSLIDPNNTAHEETKTVLSDTEEIKPQTKKETYISCPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MHTTESKNEHLEDENFQTSTTPQSLIDPNNTAHEETKTVLSDTEEIKPQTKKETYISCPL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 RGVLNVIITNGVILFVIWCMTWSILGSEALPGGNLFGLFIIFYSAIIGGKILQLIRIPLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RGVLNVIITNGVILFVIWCMTWSILGSEALPGGNLFGLFIIFYSAIIGGKILQLIRIPLV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 PPLPPLLGMLLAGFTIRNVPFINEHVHVPNTWSSILRSIALTIILIRAGLGLDPQALRHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PPLPPLLGMLLAGFTIRNVPFINEHVHVPNTWSSILRSIALTIILIRAGLGLDPQALRHL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 KVVCFRLAVGPCLMEASAAAVFSHFIMKFPWQWAFLLGFVLGAVSPAVVVPYMMVLQENG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KVVCFRLAVGPCLMEASAAAVFSHFIMKFPWQWAFLLGFVLGAVSPAVVVPYMMVLQENG 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE6 YGVEEGIPTLLMAASSMDDILAITGFNTCLSIVFSSGGILNNAIASIRNVCISLLAGIVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YGVEEGIPTLLMAASSMDDILAITGFNTCLSIVFSSGGILNNAIASIRNVCISLLAGIVL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE6 GFFVRYFPSEDQKKLTLKRGFLVLTMCVSAVLGSQRIGLHGSGGLCTLVLSFIAGTKWSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GFFVRYFPSEDQKKLTLKRGFLVLTMCVSAVLGSQRIGLHGSGGLCTLVLSFIAGTKWSQ 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE6 EKMKVQKIITTVWDIFQPLLFGLVGAEVSVSSLESNIVGISVATLSLALCVRILTTYLLM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EKMKVQKIITTVWDIFQPLLFGLVGAEVSVSSLESNIVGISVATLSLALCVRILTTYLLM 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE6 CFAGFSFKEKIFIALAWMPKATVQAVLGPLALETARVSAPHLEPYAKDVMTVAFLAILIT :::::::::::::::::::::::: NP_001 CFAGFSFKEKIFIALAWMPKATVQINQAILLLFLLREEWTNCKVAKKCEYTKERQ 430 440 450 460 470 >>XP_006714148 (OMIM: 611789) PREDICTED: mitochondrial s (537 aa) initn: 1883 init1: 1737 opt: 1887 Z-score: 2417.0 bits: 456.9 E(85289): 6.9e-128 Smith-Waterman score: 1887; 59.4% identity (86.0% similar) in 465 aa overlap (35-498:56-519) 10 20 30 40 50 60 pF1KE6 ESKNEHLEDENFQTSTTPQSLIDPNNTAHEETKTVLSDTEEIKPQTKKETYISCPLRGVL : : . :: . : .. ...:: .:.: XP_006 HQEAQEETVMKLKGIDANEPTEGSILLKSSEKKLQETPTEANHVQRLRQ-MLACPPHGLL 30 40 50 60 70 80 70 80 90 100 110 120 pF1KE6 NVIITNGVILFVIWCMTWSILGSEALPGGNLFGLFIIFYSAIIGGKILQLIRIPLVPPLP . .::: .:. ..: ..::: ::: ::::::::..:.:: ::::::.: ::..: .:::: XP_006 DRVITNVTIIVLLWAVVWSITGSECLPGGNLFGIIILFYCAIIGGKLLGLIKLPTLPPLP 90 100 110 120 130 140 130 140 150 160 170 180 pF1KE6 PLLGMLLAGFTIRNVPFINEHVHVPNTWSSILRSIALTIILIRAGLGLDPQALRHLKVVC ::::::::: :::.: ::..:.. . ::: ::::::.:::.::::::: .::..:: :: XP_006 SLLGMLLAGFLIRNIPVINDNVQIKHKWSSSLRSIALSIILVRAGLGLDSKALKKLKGVC 150 160 170 180 190 200 190 200 210 220 230 240 pF1KE6 FRLAVGPCLMEASAAAVFSHFIMKFPWQWAFLLGFVLGAVSPAVVVPYMMVLQENGYGVE ::..:::..:: ..:...:... .::::.:.::::::::::::::: :..:: .::::: XP_006 VRLSMGPCIVEACTSALLAHYLLGLPWQWGFILGFVLGAVSPAVVVPSMLLLQGGGYGVE 210 220 230 240 250 260 250 260 270 280 290 300 pF1KE6 EGIPTLLMAASSMDDILAITGFNTCLSIVFSSGGILNNAIASIRNVCISLLAGIVLGFFV .:.:::::::.:.:::::::::::::.:.::.:. . :.. .. .: :.. .: :::::. XP_006 KGVPTLLMAAGSFDDILAITGFNTCLGIAFSTGSTVFNVLRGVLEVVIGVATGSVLGFFI 270 280 290 300 310 320 310 320 330 340 350 360 pF1KE6 RYFPSEDQKKLTLKRGFLVLTMCVSAVLGSQRIGLHGSGGLCTLVLSFIAGTKWSQEKMK .::::.:: ::. :: :::: . : ::..: ..:. :::::::::..:.:: :..:: . XP_006 QYFPSRDQDKLVCKRTFLVLGLSVLAVFSSVHFGFPGSGGLCTLVMAFLAGMGWTSEKAE 330 340 350 360 370 380 370 380 390 400 410 420 pF1KE6 VQKIITTVWDIFQPLLFGLVGAEVSVSSLESNIVGISVATLSLALCVRILTTYLLMCFAG :.:::...:::::::::::.:::::..::. . ::. :::...:. .:::::.:..:::: XP_006 VEKIIAVAWDIFQPLLFGLIGAEVSIASLRPETVGLCVATVGIAVLIRILTTFLMVCFAG 390 400 410 420 430 440 430 440 450 460 470 480 pF1KE6 FSFKEKIFIALAWMPKATVQAVLGPLALETARVSAP-HLEPYAKDVMTVAFLAILITAPN :..::::::..::.:::::::..: .::.::: . .:: :. ::.:::::.:::::: XP_006 FNLKEKIFISFAWLPKATVQAAIGSVALDTARSHGEKQLEDYGMDVLTVAFLSILITAPI 450 460 470 480 490 500 490 500 510 pF1KE6 GALLMGILGPKMLTRHYDPSKIKLQLSTLEHH :.::.:.:::..: . XP_006 GSLLIGLLGPRLLQKVEHQNKDEEVQGETSVQV 510 520 530 >>NP_849155 (OMIM: 611789) mitochondrial sodium/hydrogen (537 aa) initn: 1883 init1: 1737 opt: 1887 Z-score: 2417.0 bits: 456.9 E(85289): 6.9e-128 Smith-Waterman score: 1887; 59.4% identity (86.0% similar) in 465 aa overlap (35-498:56-519) 10 20 30 40 50 60 pF1KE6 ESKNEHLEDENFQTSTTPQSLIDPNNTAHEETKTVLSDTEEIKPQTKKETYISCPLRGVL : : . :: . : .. ...:: .:.: NP_849 HQEAQEETVMKLKGIDANEPTEGSILLKSSEKKLQETPTEANHVQRLRQ-MLACPPHGLL 30 40 50 60 70 80 70 80 90 100 110 120 pF1KE6 NVIITNGVILFVIWCMTWSILGSEALPGGNLFGLFIIFYSAIIGGKILQLIRIPLVPPLP . .::: .:. ..: ..::: ::: ::::::::..:.:: ::::::.: ::..: .:::: NP_849 DRVITNVTIIVLLWAVVWSITGSECLPGGNLFGIIILFYCAIIGGKLLGLIKLPTLPPLP 90 100 110 120 130 140 130 140 150 160 170 180 pF1KE6 PLLGMLLAGFTIRNVPFINEHVHVPNTWSSILRSIALTIILIRAGLGLDPQALRHLKVVC ::::::::: :::.: ::..:.. . ::: ::::::.:::.::::::: .::..:: :: NP_849 SLLGMLLAGFLIRNIPVINDNVQIKHKWSSSLRSIALSIILVRAGLGLDSKALKKLKGVC 150 160 170 180 190 200 190 200 210 220 230 240 pF1KE6 FRLAVGPCLMEASAAAVFSHFIMKFPWQWAFLLGFVLGAVSPAVVVPYMMVLQENGYGVE ::..:::..:: ..:...:... .::::.:.::::::::::::::: :..:: .::::: NP_849 VRLSMGPCIVEACTSALLAHYLLGLPWQWGFILGFVLGAVSPAVVVPSMLLLQGGGYGVE 210 220 230 240 250 260 250 260 270 280 290 300 pF1KE6 EGIPTLLMAASSMDDILAITGFNTCLSIVFSSGGILNNAIASIRNVCISLLAGIVLGFFV .:.:::::::.:.:::::::::::::.:.::.:. . :.. .. .: :.. .: :::::. NP_849 KGVPTLLMAAGSFDDILAITGFNTCLGIAFSTGSTVFNVLRGVLEVVIGVATGSVLGFFI 270 280 290 300 310 320 310 320 330 340 350 360 pF1KE6 RYFPSEDQKKLTLKRGFLVLTMCVSAVLGSQRIGLHGSGGLCTLVLSFIAGTKWSQEKMK .::::.:: ::. :: :::: . : ::..: ..:. :::::::::..:.:: :..:: . NP_849 QYFPSRDQDKLVCKRTFLVLGLSVLAVFSSVHFGFPGSGGLCTLVMAFLAGMGWTSEKAE 330 340 350 360 370 380 370 380 390 400 410 420 pF1KE6 VQKIITTVWDIFQPLLFGLVGAEVSVSSLESNIVGISVATLSLALCVRILTTYLLMCFAG :.:::...:::::::::::.:::::..::. . ::. :::...:. .:::::.:..:::: NP_849 VEKIIAVAWDIFQPLLFGLIGAEVSIASLRPETVGLCVATVGIAVLIRILTTFLMVCFAG 390 400 410 420 430 440 430 440 450 460 470 480 pF1KE6 FSFKEKIFIALAWMPKATVQAVLGPLALETARVSAP-HLEPYAKDVMTVAFLAILITAPN :..::::::..::.:::::::..: .::.::: . .:: :. ::.:::::.:::::: NP_849 FNLKEKIFISFAWLPKATVQAAIGSVALDTARSHGEKQLEDYGMDVLTVAFLSILITAPI 450 460 470 480 490 500 490 500 510 pF1KE6 GALLMGILGPKMLTRHYDPSKIKLQLSTLEHH :.::.:.:::..: . NP_849 GSLLIGLLGPRLLQKVEHQNKDEEVQGETSVQV 510 520 530 >>NP_001287683 (OMIM: 611789) mitochondrial sodium/hydro (480 aa) initn: 1571 init1: 1425 opt: 1570 Z-score: 2011.0 bits: 381.6 E(85289): 2.8e-105 Smith-Waterman score: 1570; 61.6% identity (88.4% similar) in 372 aa overlap (128-498:91-462) 100 110 120 130 140 150 pF1KE6 LFIIFYSAIIGGKILQLIRIPLVPPLPPLLGMLLAGFTIRNVPFINEHVHVPNTWSSILR ::::::: :::.: ::..:.. . ::: :: NP_001 ETPTEANHVQRLRQMLACPPHGLLDRVITNGMLLAGFLIRNIPVINDNVQIKHKWSSSLR 70 80 90 100 110 120 160 170 180 190 200 210 pF1KE6 SIALTIILIRAGLGLDPQALRHLKVVCFRLAVGPCLMEASAAAVFSHFIMKFPWQWAFLL ::::.:::.::::::: .::..:: :: ::..:::..:: ..:...:... .::::.:.: NP_001 SIALSIILVRAGLGLDSKALKKLKGVCVRLSMGPCIVEACTSALLAHYLLGLPWQWGFIL 130 140 150 160 170 180 220 230 240 250 260 270 pF1KE6 GFVLGAVSPAVVVPYMMVLQENGYGVEEGIPTLLMAASSMDDILAITGFNTCLSIVFSSG :::::::::::::: :..:: .:::::.:.:::::::.:.:::::::::::::.:.::.: NP_001 GFVLGAVSPAVVVPSMLLLQGGGYGVEKGVPTLLMAAGSFDDILAITGFNTCLGIAFSTG 190 200 210 220 230 240 280 290 300 310 320 330 pF1KE6 GILNNAIASIRNVCISLLAGIVLGFFVRYFPSEDQKKLTLKRGFLVLTMCVSAVLGSQRI . . :.. .. .: :.. .: :::::..::::.:: ::. :: :::: . : ::..: .. NP_001 STVFNVLRGVLEVVIGVATGSVLGFFIQYFPSRDQDKLVCKRTFLVLGLSVLAVFSSVHF 250 260 270 280 290 300 340 350 360 370 380 390 pF1KE6 GLHGSGGLCTLVLSFIAGTKWSQEKMKVQKIITTVWDIFQPLLFGLVGAEVSVSSLESNI :. :::::::::..:.:: :..:: .:.:::...:::::::::::.:::::..::. . NP_001 GFPGSGGLCTLVMAFLAGMGWTSEKAEVEKIIAVAWDIFQPLLFGLIGAEVSIASLRPET 310 320 330 340 350 360 400 410 420 430 440 450 pF1KE6 VGISVATLSLALCVRILTTYLLMCFAGFSFKEKIFIALAWMPKATVQAVLGPLALETARV ::. :::...:. .:::::.:..:::::..::::::..::.:::::::..: .::.::: NP_001 VGLCVATVGIAVLIRILTTFLMVCFAGFNLKEKIFISFAWLPKATVQAAIGSVALDTARS 370 380 390 400 410 420 460 470 480 490 500 510 pF1KE6 SAP-HLEPYAKDVMTVAFLAILITAPNGALLMGILGPKMLTRHYDPSKIKLQLSTLEHH . .:: :. ::.:::::.:::::: :.::.:.:::..: . NP_001 HGEKQLEDYGMDVLTVAFLSILITAPIGSLLIGLLGPRLLQKVEHQNKDEEVQGETSVQV 430 440 450 460 470 480 >>XP_006714149 (OMIM: 611789) PREDICTED: mitochondrial s (480 aa) initn: 1571 init1: 1425 opt: 1570 Z-score: 2011.0 bits: 381.6 E(85289): 2.8e-105 Smith-Waterman score: 1570; 61.6% identity (88.4% similar) in 372 aa overlap (128-498:91-462) 100 110 120 130 140 150 pF1KE6 LFIIFYSAIIGGKILQLIRIPLVPPLPPLLGMLLAGFTIRNVPFINEHVHVPNTWSSILR ::::::: :::.: ::..:.. . ::: :: XP_006 ETPTEANHVQRLRQMLACPPHGLLDRVITNGMLLAGFLIRNIPVINDNVQIKHKWSSSLR 70 80 90 100 110 120 160 170 180 190 200 210 pF1KE6 SIALTIILIRAGLGLDPQALRHLKVVCFRLAVGPCLMEASAAAVFSHFIMKFPWQWAFLL ::::.:::.::::::: .::..:: :: ::..:::..:: ..:...:... .::::.:.: XP_006 SIALSIILVRAGLGLDSKALKKLKGVCVRLSMGPCIVEACTSALLAHYLLGLPWQWGFIL 130 140 150 160 170 180 220 230 240 250 260 270 pF1KE6 GFVLGAVSPAVVVPYMMVLQENGYGVEEGIPTLLMAASSMDDILAITGFNTCLSIVFSSG :::::::::::::: :..:: .:::::.:.:::::::.:.:::::::::::::.:.::.: XP_006 GFVLGAVSPAVVVPSMLLLQGGGYGVEKGVPTLLMAAGSFDDILAITGFNTCLGIAFSTG 190 200 210 220 230 240 280 290 300 310 320 330 pF1KE6 GILNNAIASIRNVCISLLAGIVLGFFVRYFPSEDQKKLTLKRGFLVLTMCVSAVLGSQRI . . :.. .. .: :.. .: :::::..::::.:: ::. :: :::: . : ::..: .. XP_006 STVFNVLRGVLEVVIGVATGSVLGFFIQYFPSRDQDKLVCKRTFLVLGLSVLAVFSSVHF 250 260 270 280 290 300 340 350 360 370 380 390 pF1KE6 GLHGSGGLCTLVLSFIAGTKWSQEKMKVQKIITTVWDIFQPLLFGLVGAEVSVSSLESNI :. :::::::::..:.:: :..:: .:.:::...:::::::::::.:::::..::. . XP_006 GFPGSGGLCTLVMAFLAGMGWTSEKAEVEKIIAVAWDIFQPLLFGLIGAEVSIASLRPET 310 320 330 340 350 360 400 410 420 430 440 450 pF1KE6 VGISVATLSLALCVRILTTYLLMCFAGFSFKEKIFIALAWMPKATVQAVLGPLALETARV ::. :::...:. .:::::.:..:::::..::::::..::.:::::::..: .::.::: XP_006 VGLCVATVGIAVLIRILTTFLMVCFAGFNLKEKIFISFAWLPKATVQAAIGSVALDTARS 370 380 390 400 410 420 460 470 480 490 500 510 pF1KE6 SAP-HLEPYAKDVMTVAFLAILITAPNGALLMGILGPKMLTRHYDPSKIKLQLSTLEHH . .:: :. ::.:::::.:::::: :.::.:.:::..: . XP_006 HGEKQLEDYGMDVLTVAFLSILITAPIGSLLIGLLGPRLLQKVEHQNKDEEVQGETSVQV 430 440 450 460 470 480 >>NP_001287685 (OMIM: 611789) mitochondrial sodium/hydro (417 aa) initn: 1171 init1: 1171 opt: 1171 Z-score: 1500.0 bits: 286.8 E(85289): 8.2e-77 Smith-Waterman score: 1171; 62.1% identity (88.2% similar) in 272 aa overlap (128-399:91-362) 100 110 120 130 140 150 pF1KE6 LFIIFYSAIIGGKILQLIRIPLVPPLPPLLGMLLAGFTIRNVPFINEHVHVPNTWSSILR ::::::: :::.: ::..:.. . ::: :: NP_001 ETPTEANHVQRLRQMLACPPHGLLDRVITNGMLLAGFLIRNIPVINDNVQIKHKWSSSLR 70 80 90 100 110 120 160 170 180 190 200 210 pF1KE6 SIALTIILIRAGLGLDPQALRHLKVVCFRLAVGPCLMEASAAAVFSHFIMKFPWQWAFLL ::::.:::.::::::: .::..:: :: ::..:::..:: ..:...:... .::::.:.: NP_001 SIALSIILVRAGLGLDSKALKKLKGVCVRLSMGPCIVEACTSALLAHYLLGLPWQWGFIL 130 140 150 160 170 180 220 230 240 250 260 270 pF1KE6 GFVLGAVSPAVVVPYMMVLQENGYGVEEGIPTLLMAASSMDDILAITGFNTCLSIVFSSG :::::::::::::: :..:: .:::::.:.:::::::.:.:::::::::::::.:.::.: NP_001 GFVLGAVSPAVVVPSMLLLQGGGYGVEKGVPTLLMAAGSFDDILAITGFNTCLGIAFSTG 190 200 210 220 230 240 280 290 300 310 320 330 pF1KE6 GILNNAIASIRNVCISLLAGIVLGFFVRYFPSEDQKKLTLKRGFLVLTMCVSAVLGSQRI . . :.. .. .: :.. .: :::::..::::.:: ::. :: :::: . : ::..: .. NP_001 STVFNVLRGVLEVVIGVATGSVLGFFIQYFPSRDQDKLVCKRTFLVLGLSVLAVFSSVHF 250 260 270 280 290 300 340 350 360 370 380 390 pF1KE6 GLHGSGGLCTLVLSFIAGTKWSQEKMKVQKIITTVWDIFQPLLFGLVGAEVSVSSLESNI :. :::::::::..:.:: :..:: .:.:::...:::::::::::.:::::..::. . NP_001 GFPGSGGLCTLVMAFLAGMGWTSEKAEVEKIIAVAWDIFQPLLFGLIGAEVSIASLRPET 310 320 330 340 350 360 400 410 420 430 440 450 pF1KE6 VGISVATLSLALCVRILTTYLLMCFAGFSFKEKIFIALAWMPKATVQAVLGPLALETARV :: NP_001 VGCNRICGFGHSKVTWRETIRRLWNGCVDSGIFVHPHHSPNWKSAYWFTGPQASAES 370 380 390 400 410 515 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 13:34:55 2016 done: Tue Nov 8 13:34:56 2016 Total Scan time: 5.950 Total Display time: 0.060 Function used was FASTA [36.3.4 Apr, 2011]