FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE6371, 423 aa 1>>>pF1KE6371 423 - 423 aa - 423 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.4887+/-0.000431; mu= 16.1988+/- 0.027 mean_var=79.5320+/-16.775, 0's: 0 Z-trim(112.0): 311 B-trim: 662 in 1/53 Lambda= 0.143815 statistics sampled from 20400 (20746) to 20400 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.617), E-opt: 0.2 (0.243), width: 16 Scan time: 6.570 The best scores are: opt bits E(85289) NP_054777 (OMIM: 610399) transmembrane protease se ( 423) 2891 609.9 3.8e-174 XP_011530198 (OMIM: 610399) PREDICTED: transmembra ( 345) 2368 501.3 1.5e-141 NP_001107859 (OMIM: 611704) transmembrane protease ( 418) 1277 275.0 2.4e-73 NP_872412 (OMIM: 611704) transmembrane protease se ( 421) 1266 272.7 1.2e-72 NP_004253 (OMIM: 605369) transmembrane protease se ( 418) 1153 249.3 1.4e-65 XP_005265767 (OMIM: 605369) PREDICTED: transmembra ( 301) 929 202.7 1e-51 XP_016864340 (OMIM: 605369) PREDICTED: transmembra ( 234) 900 196.6 5.4e-50 NP_001275930 (OMIM: 206200,609862) transmembrane p ( 802) 749 165.7 3.9e-40 NP_705837 (OMIM: 206200,609862) transmembrane prot ( 811) 749 165.7 3.9e-40 NP_001243246 (OMIM: 605511) transmembrane protease ( 453) 693 153.9 7.8e-37 NP_001193718 (OMIM: 610050) transmembrane protease ( 532) 692 153.7 1e-36 NP_001231924 (OMIM: 610050) transmembrane protease ( 563) 692 153.7 1.1e-36 NP_001070731 (OMIM: 610050) transmembrane protease ( 567) 692 153.7 1.1e-36 NP_115780 (OMIM: 605511) transmembrane protease se ( 327) 681 151.3 3.4e-36 NP_076927 (OMIM: 605511) transmembrane protease se ( 454) 681 151.4 4.4e-36 NP_001275679 (OMIM: 606751) transmembrane protease ( 413) 679 150.9 5.4e-36 NP_001275680 (OMIM: 606751) transmembrane protease ( 448) 679 151.0 5.8e-36 NP_110397 (OMIM: 606751) transmembrane protease se ( 457) 679 151.0 5.9e-36 XP_011528035 (OMIM: 602060) PREDICTED: transmembra ( 384) 677 150.5 6.8e-36 XP_005261100 (OMIM: 602060) PREDICTED: transmembra ( 452) 677 150.6 7.8e-36 XP_011528033 (OMIM: 602060) PREDICTED: transmembra ( 492) 677 150.6 8.3e-36 NP_005647 (OMIM: 602060) transmembrane protease se ( 492) 677 150.6 8.3e-36 NP_001128571 (OMIM: 602060) transmembrane protease ( 529) 677 150.6 8.8e-36 NP_068813 (OMIM: 606797) suppressor of tumorigenic ( 855) 661 147.4 1.3e-34 NP_001277025 (OMIM: 606565) transmembrane protease ( 290) 645 143.8 5.4e-34 XP_011526284 (OMIM: 610477) PREDICTED: transmembra ( 562) 648 144.6 6e-34 NP_001167023 (OMIM: 606565) transmembrane protease ( 397) 645 143.9 7e-34 XP_011526282 (OMIM: 610477) PREDICTED: transmembra ( 690) 648 144.7 7e-34 NP_002763 (OMIM: 226200,606635) enteropeptidase pr (1019) 650 145.2 7.2e-34 NP_001277023 (OMIM: 606565) transmembrane protease ( 412) 645 143.9 7.2e-34 XP_011527961 (OMIM: 226200,606635) PREDICTED: ente (1034) 650 145.2 7.2e-34 XP_011527960 (OMIM: 226200,606635) PREDICTED: ente (1037) 650 145.2 7.3e-34 XP_011527959 (OMIM: 226200,606635) PREDICTED: ente (1049) 650 145.2 7.3e-34 XP_011527958 (OMIM: 226200,606635) PREDICTED: ente (1064) 650 145.2 7.4e-34 XP_011527956 (OMIM: 226200,606635) PREDICTED: ente (1064) 650 145.2 7.4e-34 XP_011527957 (OMIM: 226200,606635) PREDICTED: ente (1064) 650 145.2 7.4e-34 NP_001077416 (OMIM: 606565) transmembrane protease ( 432) 645 143.9 7.5e-34 NP_001167022 (OMIM: 606565) transmembrane protease ( 435) 645 143.9 7.5e-34 NP_063947 (OMIM: 606565) transmembrane protease se ( 437) 645 143.9 7.5e-34 NP_892018 (OMIM: 610477) transmembrane protease se (1059) 648 144.8 9.8e-34 XP_011526280 (OMIM: 610477) PREDICTED: transmembra (1093) 648 144.8 1e-33 XP_005271672 (OMIM: 606565) PREDICTED: transmembra ( 454) 633 141.4 4.4e-33 XP_011541204 (OMIM: 606565) PREDICTED: transmembra ( 456) 633 141.4 4.4e-33 XP_011541203 (OMIM: 606565) PREDICTED: transmembra ( 489) 633 141.5 4.6e-33 XP_005271671 (OMIM: 606565) PREDICTED: transmembra ( 492) 633 141.5 4.6e-33 XP_005271670 (OMIM: 606565) PREDICTED: transmembra ( 494) 633 141.5 4.7e-33 NP_001182058 (OMIM: 613517,613858) serine protease ( 603) 618 138.4 4.7e-32 NP_036599 (OMIM: 609341) tryptase gamma preproprot ( 321) 613 137.2 5.9e-32 XP_011520748 (OMIM: 609341) PREDICTED: tryptase ga ( 346) 611 136.8 8.3e-32 XP_011520749 (OMIM: 609341) PREDICTED: tryptase ga ( 346) 611 136.8 8.3e-32 >>NP_054777 (OMIM: 610399) transmembrane protease serine (423 aa) initn: 2891 init1: 2891 opt: 2891 Z-score: 3247.4 bits: 609.9 E(85289): 3.8e-174 Smith-Waterman score: 2891; 100.0% identity (100.0% similar) in 423 aa overlap (1-423:1-423) 10 20 30 40 50 60 pF1KE6 MMYRPDVVRARKRVCWEPWVIGLVIFISLIVLAVCIGLTVHYVRYNQKKTYNYYSTLSFT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_054 MMYRPDVVRARKRVCWEPWVIGLVIFISLIVLAVCIGLTVHYVRYNQKKTYNYYSTLSFT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 TDKLYAEFGREASNNFTEMSQRLESMVKNAFYKSPLREEFVKSQVIKFSQQKHGVLAHML :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_054 TDKLYAEFGREASNNFTEMSQRLESMVKNAFYKSPLREEFVKSQVIKFSQQKHGVLAHML 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 LICRFHSTEDPETVDKIVQLVLHEKLQDAVGPPKVDPHSVKIKKINKTETDSYLNHCCGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_054 LICRFHSTEDPETVDKIVQLVLHEKLQDAVGPPKVDPHSVKIKKINKTETDSYLNHCCGT 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 RRSKTLGQSLRIVGGTEVEEGEWPWQASLQWDGSHRCGATLINATWLVSAAHCFTTYKNP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_054 RRSKTLGQSLRIVGGTEVEEGEWPWQASLQWDGSHRCGATLINATWLVSAAHCFTTYKNP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE6 ARWTASFGVTIKPSKMKRGLRRIIVHEKYKHPSHDYDISLAELSSPVPYTNAVHRVCLPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_054 ARWTASFGVTIKPSKMKRGLRRIIVHEKYKHPSHDYDISLAELSSPVPYTNAVHRVCLPD 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE6 ASYEFQPGDVMFVTGFGALKNDGYSQNHLRQAQVTLIDATTCNEPQAYNDAITPRMLCAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_054 ASYEFQPGDVMFVTGFGALKNDGYSQNHLRQAQVTLIDATTCNEPQAYNDAITPRMLCAG 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE6 SLEGKTDACQGDSGGPLVSSDARDIWYLAGIVSWGDECAKPNKPGVYTRVTALRDWITSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_054 SLEGKTDACQGDSGGPLVSSDARDIWYLAGIVSWGDECAKPNKPGVYTRVTALRDWITSK 370 380 390 400 410 420 pF1KE6 TGI ::: NP_054 TGI >>XP_011530198 (OMIM: 610399) PREDICTED: transmembrane p (345 aa) initn: 2368 init1: 2368 opt: 2368 Z-score: 2662.2 bits: 501.3 E(85289): 1.5e-141 Smith-Waterman score: 2368; 100.0% identity (100.0% similar) in 345 aa overlap (79-423:1-345) 50 60 70 80 90 100 pF1KE6 KTYNYYSTLSFTTDKLYAEFGREASNNFTEMSQRLESMVKNAFYKSPLREEFVKSQVIKF :::::::::::::::::::::::::::::: XP_011 MSQRLESMVKNAFYKSPLREEFVKSQVIKF 10 20 30 110 120 130 140 150 160 pF1KE6 SQQKHGVLAHMLLICRFHSTEDPETVDKIVQLVLHEKLQDAVGPPKVDPHSVKIKKINKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SQQKHGVLAHMLLICRFHSTEDPETVDKIVQLVLHEKLQDAVGPPKVDPHSVKIKKINKT 40 50 60 70 80 90 170 180 190 200 210 220 pF1KE6 ETDSYLNHCCGTRRSKTLGQSLRIVGGTEVEEGEWPWQASLQWDGSHRCGATLINATWLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ETDSYLNHCCGTRRSKTLGQSLRIVGGTEVEEGEWPWQASLQWDGSHRCGATLINATWLV 100 110 120 130 140 150 230 240 250 260 270 280 pF1KE6 SAAHCFTTYKNPARWTASFGVTIKPSKMKRGLRRIIVHEKYKHPSHDYDISLAELSSPVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SAAHCFTTYKNPARWTASFGVTIKPSKMKRGLRRIIVHEKYKHPSHDYDISLAELSSPVP 160 170 180 190 200 210 290 300 310 320 330 340 pF1KE6 YTNAVHRVCLPDASYEFQPGDVMFVTGFGALKNDGYSQNHLRQAQVTLIDATTCNEPQAY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YTNAVHRVCLPDASYEFQPGDVMFVTGFGALKNDGYSQNHLRQAQVTLIDATTCNEPQAY 220 230 240 250 260 270 350 360 370 380 390 400 pF1KE6 NDAITPRMLCAGSLEGKTDACQGDSGGPLVSSDARDIWYLAGIVSWGDECAKPNKPGVYT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NDAITPRMLCAGSLEGKTDACQGDSGGPLVSSDARDIWYLAGIVSWGDECAKPNKPGVYT 280 290 300 310 320 330 410 420 pF1KE6 RVTALRDWITSKTGI ::::::::::::::: XP_011 RVTALRDWITSKTGI 340 >>NP_001107859 (OMIM: 611704) transmembrane protease ser (418 aa) initn: 1093 init1: 974 opt: 1277 Z-score: 1437.6 bits: 275.0 E(85289): 2.4e-73 Smith-Waterman score: 1277; 42.8% identity (75.4% similar) in 423 aa overlap (1-423:1-418) 10 20 30 40 50 60 pF1KE6 MMYRPDVVRARKRVCWEPWVIGLVIFISLIVLAVCIGLTVHYVRYNQKKTYNYYSTLSFT :::: .:.: .::.:...: .:: :.:: ::: ::.. ..::: : :...... NP_001 MMYRTVGFGTRSR-NLKPWMIAVLIVLSLTVVAVTIGLLVHFLVFDQKKEY-YHGSFKIL 10 20 30 40 50 70 80 90 100 110 120 pF1KE6 TDKLYAEFGREASNNFTEMSQRLESMVKNAFYKSPLREEFVKSQVIKFSQQKHGVLAHML .. .::. . .. .. . :..: . : : .....:.::.... .. :: . .. NP_001 DPQINNNFGQSNTYQLKDLRETTENLVDEIFIDSAWKKNYIKNQVVRLTPEEDGVKVDVI 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE6 LICRFHSTEDPETVDKIVQLVLHEKLQDAVGPPKVDPHSVKIKKINKTETDSYLNHCCGT .. .: :::. . .: .: .:..:... . : .. ::... .... . .. :: NP_001 MVFQFPSTEQRAVREKKIQSILNQKIRNLRALP-INASSVQVNAMSSSTGELTVQASCG- 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE6 RRSKTLGQSLRIVGGTEVEEGEWPWQASLQWDGSHRCGATLINATWLVSAAHCFTTYKNP .: :. . ::..:. . .. ::::::::.:. :.::::::. ::::.::::: :::: NP_001 KRVVPLNVN-RIASGVIAPKAAWPWQASLQYDNIHQCGATLISNTWLVTAAHCFQKYKNP 180 190 200 210 220 230 250 260 270 280 290 300 pF1KE6 ARWTASFGVTIKPSKMKRGLRRIIVHEKYKHPSHDYDISLAELSSPVPYTNAVHRVCLPD .::.:::. :.: :::..::.:.::::. ...:::.....:: : ... ....:::. NP_001 HQWTVSFGTKINPPLMKRNVRRFIIHEKYRSAAREYDIAVVQVSSRVTFSDDIRQICLPE 240 250 260 270 280 290 310 320 330 340 350 360 pF1KE6 ASYEFQPGDVMFVTGFGALKNDGYSQNHLRQAQVTLIDATTCNEPQAYNDAITPRMLCAG :: :::. .. .:::::: : ::: ::.:.: .:. .:..::.:.. : : :.::: NP_001 ASASFQPNLTVHITGFGALYYGGESQNDLREARVKIISDDVCKQPQVYGNDIKPGMFCAG 300 310 320 330 340 350 370 380 390 400 410 420 pF1KE6 SLEGKTDACQGDSGGPLVSSDARDIWYLAGIVSWGDECAKPNKPGVYTRVTALRDWITSK .:: :::.::::::::. : .: ::: :::::::.:.. .::::::.:: :.::.:: NP_001 YMEGIYDACRGDSGGPLVTRDLKDTWYLIGIVSWGDNCGQKDKPGVYTQVTYYRNWIASK 360 370 380 390 400 410 pF1KE6 TGI ::: NP_001 TGI >>NP_872412 (OMIM: 611704) transmembrane protease serine (421 aa) initn: 1187 init1: 974 opt: 1266 Z-score: 1425.3 bits: 272.7 E(85289): 1.2e-72 Smith-Waterman score: 1266; 43.0% identity (75.1% similar) in 426 aa overlap (1-423:1-421) 10 20 30 40 50 60 pF1KE6 MMYRPDVVRARKRVCWEPWVIGLVIFISLIVLAVCIGLTVHYVRYNQKKTYNYYSTLSFT :::: .:.: .::.:...: .:: :.:: ::: ::.. ..::: : :...... NP_872 MMYRTVGFGTRSR-NLKPWMIAVLIVLSLTVVAVTIGLLVHFLVFDQKKEY-YHGSFKIL 10 20 30 40 50 70 80 90 100 110 pF1KE6 TDKLYAEFGREAS---NNFTEMSQRLESMVKNAFYKSPLREEFVKSQVIKFSQQKHGVLA .. .::. . ... : .. : :.: . : : .....:.::.... .. :: . NP_872 DPQINNNFGQSNTYQLKDLRETTENLVSQVDEIFIDSAWKKNYIKNQVVRLTPEEDGVKV 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE6 HMLLICRFHSTEDPETVDKIVQLVLHEKLQDAVGPPKVDPHSVKIKKINKTETDSYLNHC .... .: :::. . .: .: .:..:... . : .. ::... .... . .. NP_872 DVIMVFQFPSTEQRAVREKKIQSILNQKIRNLRALP-INASSVQVNAMSSSTGELTVQAS 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE6 CGTRRSKTLGQSLRIVGGTEVEEGEWPWQASLQWDGSHRCGATLINATWLVSAAHCFTTY :: .: :. . ::..:. . .. ::::::::.:. :.::::::. ::::.::::: : NP_872 CG-KRVVPLNVN-RIASGVIAPKAAWPWQASLQYDNIHQCGATLISNTWLVTAAHCFQKY 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE6 KNPARWTASFGVTIKPSKMKRGLRRIIVHEKYKHPSHDYDISLAELSSPVPYTNAVHRVC ::: .::.:::. :.: :::..::.:.::::. ...:::.....:: : ... ....: NP_872 KNPHQWTVSFGTKINPPLMKRNVRRFIIHEKYRSAAREYDIAVVQVSSRVTFSDDIRQIC 240 250 260 270 280 290 300 310 320 330 340 350 pF1KE6 LPDASYEFQPGDVMFVTGFGALKNDGYSQNHLRQAQVTLIDATTCNEPQAYNDAITPRML ::.:: :::. .. .:::::: : ::: ::.:.: .:. .:..::.:.. : : :. NP_872 LPEASASFQPNLTVHITGFGALYYGGESQNDLREARVKIISDDVCKQPQVYGNDIKPGMF 300 310 320 330 340 350 360 370 380 390 400 410 pF1KE6 CAGSLEGKTDACQGDSGGPLVSSDARDIWYLAGIVSWGDECAKPNKPGVYTRVTALRDWI ::: .:: :::.::::::::. : .: ::: :::::::.:.. .::::::.:: :.:: NP_872 CAGYMEGIYDACRGDSGGPLVTRDLKDTWYLIGIVSWGDNCGQKDKPGVYTQVTYYRNWI 360 370 380 390 400 410 420 pF1KE6 TSKTGI .::::: NP_872 ASKTGI 420 >>NP_004253 (OMIM: 605369) transmembrane protease serine (418 aa) initn: 900 init1: 900 opt: 1153 Z-score: 1298.6 bits: 249.3 E(85289): 1.4e-65 Smith-Waterman score: 1153; 38.9% identity (73.0% similar) in 422 aa overlap (2-423:1-418) 10 20 30 40 50 60 pF1KE6 MMYRPDVVRARKRVCWEPWVIGLVIFISLIVLAVCIGLTVHYVRYNQKKTYNYYSTLSFT :::: : . .: .:.:. ... ....::: :.: :... ..:: .: : :.... NP_004 MYRPARVTSTSRFL-NPYVVCFIVVAGVVILAVTIALLVYFLAFDQK-SYFYRSSFQLL 10 20 30 40 50 70 80 90 100 110 120 pF1KE6 TDKLYAEFGREASNNFTEMSQRLESMVKNAFYKSPLREEFVKSQVIKFSQQKHGVLAHML . . .... :.... .: :.::.. ..: .: ::..:....: :. :. :: : .. NP_004 NVEYNSQLNSPATQEYRTLSGRIESLITKTFKESNLRNQFIRAHVAKLRQDGSGVRADVV 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE6 LICRFHSTEDPETVDKIVQLVLHEKLQDAVGPPKVDPHSVKIKKINKTETDSYLNHCCGT . .: ... .. . .. ::.. :... : ...: :..: ... . ..: . ::. NP_004 MKFQFTRNNNGASMKSRIESVLRQMLNNS-GNLEINP-STEITSLTDQAAANWLINECGA 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE6 RRSKTLGQSLRIVGGTEVEEGEWPWQASLQWDGSHRCGATLINATWLVSAAHCFTTYKNP . . ::.::::.::: ::::.::. ...:.::..::: :...::::: . .:: NP_004 GPDLITLSEQRILGGTEAEEGSWPWQVSLRLNNAHHCGGSLINNMWILTAAHCFRSNSNP 180 190 200 210 220 230 250 260 270 280 290 300 pF1KE6 ARWTASFGVTIKPSKMKRGLRRIIVHEKYKHPSHDYDISLAELSSPVPYTNAVHRVCLPD : :. :.. :.. .: :..:..:: .:. ::.:..: . : .:. .: :::: NP_004 RDWIATSGISTTFPKLRMRVRNILIHNNYKSATHENDIALVRLENSVTFTKDIHSVCLPA 240 250 260 270 280 290 310 320 330 340 350 360 pF1KE6 ASYEFQPGDVMFVTGFGALKNDGYSQNHLRQAQVTLIDATTCNEPQAYNDAITPRMLCAG :. .. ::.. .:::.:: . :.. .:::.:: .:. .:: :..:: :: ::::: NP_004 ATQNIPPGSTAYVTGWGAQEYAGHTVPELRQGQVRIISNDVCNAPHSYNGAILSGMLCAG 300 310 320 330 340 350 370 380 390 400 410 420 pF1KE6 SLEGKTDACQGDSGGPLVSSDARDIWYLAGIVSWGDECAKPNKPGVYTRVTALRDWITSK .: .::::::::::::. :.: .:...:::::::.:. :.:::::::::: ::: .. NP_004 VPQGGVDACQGDSGGPLVQEDSRRLWFIVGIVSWGDQCGLPDKPGVYTRVTAYLDWIRQQ 360 370 380 390 400 410 pF1KE6 TGI ::: NP_004 TGI >>XP_005265767 (OMIM: 605369) PREDICTED: transmembrane p (301 aa) initn: 900 init1: 900 opt: 929 Z-score: 1049.4 bits: 202.7 E(85289): 1e-51 Smith-Waterman score: 929; 43.0% identity (74.0% similar) in 300 aa overlap (124-423:4-301) 100 110 120 130 140 150 pF1KE6 SPLREEFVKSQVIKFSQQKHGVLAHMLLICRFHSTEDPETVDKIVQLVLHEKLQDAVGPP .: ... .. . .. ::.. :... : XP_005 MKFQFTRNNNGASMKSRIESVLRQMLNNS-GNL 10 20 30 160 170 180 190 200 210 pF1KE6 KVDPHSVKIKKINKTETDSYLNHCCGTRRSKTLGQSLRIVGGTEVEEGEWPWQASLQWDG ...: :..: ... . ..: . ::. . . ::.::::.::: ::::.::. .. XP_005 EINP-STEITSLTDQAAANWLINECGAGPDLITLSEQRILGGTEAEEGSWPWQVSLRLNN 40 50 60 70 80 90 220 230 240 250 260 270 pF1KE6 SHRCGATLINATWLVSAAHCFTTYKNPARWTASFGVTIKPSKMKRGLRRIIVHEKYKHPS .:.::..::: :...::::: . .:: : :. :.. :.. .: :..:..:: . XP_005 AHHCGGSLINNMWILTAAHCFRSNSNPRDWIATSGISTTFPKLRMRVRNILIHNNYKSAT 100 110 120 130 140 150 280 290 300 310 320 330 pF1KE6 HDYDISLAELSSPVPYTNAVHRVCLPDASYEFQPGDVMFVTGFGALKNDGYSQNHLRQAQ :. ::.:..: . : .:. .: :::: :. .. ::.. .:::.:: . :.. .:::.: XP_005 HENDIALVRLENSVTFTKDIHSVCLPAATQNIPPGSTAYVTGWGAQEYAGHTVPELRQGQ 160 170 180 190 200 210 340 350 360 370 380 390 pF1KE6 VTLIDATTCNEPQAYNDAITPRMLCAGSLEGKTDACQGDSGGPLVSSDARDIWYLAGIVS : .:. .:: :..:: :: ::::: .: .::::::::::::. :.: .:...:::: XP_005 VRIISNDVCNAPHSYNGAILSGMLCAGVPQGGVDACQGDSGGPLVQEDSRRLWFIVGIVS 220 230 240 250 260 270 400 410 420 pF1KE6 WGDECAKPNKPGVYTRVTALRDWITSKTGI :::.:. :.:::::::::: ::: ..::: XP_005 WGDQCGLPDKPGVYTRVTAYLDWIRQQTGI 280 290 300 >>XP_016864340 (OMIM: 605369) PREDICTED: transmembrane p (234 aa) initn: 900 init1: 900 opt: 900 Z-score: 1018.5 bits: 196.6 E(85289): 5.4e-50 Smith-Waterman score: 900; 50.4% identity (78.2% similar) in 234 aa overlap (190-423:1-234) 160 170 180 190 200 210 pF1KE6 VKIKKINKTETDSYLNHCCGTRRSKTLGQSLRIVGGTEVEEGEWPWQASLQWDGSHRCGA .::.::::.::: ::::.::. ...:.::. XP_016 MRILGGTEAEEGSWPWQVSLRLNNAHHCGG 10 20 30 220 230 240 250 260 270 pF1KE6 TLINATWLVSAAHCFTTYKNPARWTASFGVTIKPSKMKRGLRRIIVHEKYKHPSHDYDIS .::: :...::::: . .:: : :. :.. :.. .: :..:..:: .:. ::. XP_016 SLINNMWILTAAHCFRSNSNPRDWIATSGISTTFPKLRMRVRNILIHNNYKSATHENDIA 40 50 60 70 80 90 280 290 300 310 320 330 pF1KE6 LAELSSPVPYTNAVHRVCLPDASYEFQPGDVMFVTGFGALKNDGYSQNHLRQAQVTLIDA :..: . : .:. .: :::: :. .. ::.. .:::.:: . :.. .:::.:: .:. XP_016 LVRLENSVTFTKDIHSVCLPAATQNIPPGSTAYVTGWGAQEYAGHTVPELRQGQVRIISN 100 110 120 130 140 150 340 350 360 370 380 390 pF1KE6 TTCNEPQAYNDAITPRMLCAGSLEGKTDACQGDSGGPLVSSDARDIWYLAGIVSWGDECA .:: :..:: :: ::::: .: .::::::::::::. :.: .:...:::::::.:. XP_016 DVCNAPHSYNGAILSGMLCAGVPQGGVDACQGDSGGPLVQEDSRRLWFIVGIVSWGDQCG 160 170 180 190 200 210 400 410 420 pF1KE6 KPNKPGVYTRVTALRDWITSKTGI :.:::::::::: ::: ..::: XP_016 LPDKPGVYTRVTAYLDWIRQQTGI 220 230 >>NP_001275930 (OMIM: 206200,609862) transmembrane prote (802 aa) initn: 737 init1: 303 opt: 749 Z-score: 841.6 bits: 165.7 E(85289): 3.9e-40 Smith-Waterman score: 749; 45.8% identity (68.7% similar) in 249 aa overlap (176-417:556-797) 150 160 170 180 190 200 pF1KE6 LQDAVGPPKVDPHSVKIKKINKTETDSYLNHC-CGTRRSKTLGQSLRIVGGTEVEEGEWP :: :: . : : :::::. ::::: NP_001 TFQCEDRSCVKKPNPQCDGRPDCRDGSDEEHCDCGLQ-----GPSSRIVGGAVSSEGEWP 530 540 550 560 570 580 210 220 230 240 250 pF1KE6 WQASLQWDGSHRCGATLINATWLVSAAHCFT--TYKNPARWTASFGVTIK----PSKMKR :::::: : : ::..:: :...::::: .. . . ::. .: . . :.... NP_001 WQASLQVRGRHICGGALIADRWVITAAHCFQEDSMASTVLWTVFLGKVWQNSRWPGEVSF 590 600 610 620 630 640 260 270 280 290 300 310 pF1KE6 GLRRIIVHEKYKHPSHDYDISLAELSSPVPYTNAVHRVCLPDASYEFQPGDVMFVTGFGA . :...: ... :::::..: .:. :: . ::. :::: :. :.:: ..::.:: NP_001 KVSRLLLHPYHEEDSHDYDVALLQLDHPVVRSAAVRPVCLPARSHFFEPGLHCWITGWGA 650 660 670 680 690 700 320 330 340 350 360 370 pF1KE6 LKNDGYSQNHLRQAQVTLIDATTCNEPQAYNDAITPRMLCAGSLEGKTDACQGDSGGPLV :.. : .: :....: :: :.: .: .:::::::: .:: :::::::::::: NP_001 LREGGPISNALQKVDVQLIPQDLCSE--VYRYQVTPRMLCAGYRKGKKDACQGDSGGPLV 710 720 730 740 750 380 390 400 410 420 pF1KE6 SSDARDIWYLAGIVSWGDECAKPNKPGVYTRVTALRDWITSKTGI . :.:::.:::: :..:: :::::.:.. .:: NP_001 CKALSGRWFLAGLVSWGLGCGRPNYFGVYTRITGVISWIQQVVT 760 770 780 790 800 >>NP_705837 (OMIM: 206200,609862) transmembrane protease (811 aa) initn: 737 init1: 303 opt: 749 Z-score: 841.5 bits: 165.7 E(85289): 3.9e-40 Smith-Waterman score: 749; 45.8% identity (68.7% similar) in 249 aa overlap (176-417:565-806) 150 160 170 180 190 200 pF1KE6 LQDAVGPPKVDPHSVKIKKINKTETDSYLNHC-CGTRRSKTLGQSLRIVGGTEVEEGEWP :: :: . : : :::::. ::::: NP_705 TFQCEDRSCVKKPNPQCDGRPDCRDGSDEEHCDCGLQ-----GPSSRIVGGAVSSEGEWP 540 550 560 570 580 210 220 230 240 250 pF1KE6 WQASLQWDGSHRCGATLINATWLVSAAHCFT--TYKNPARWTASFGVTIK----PSKMKR :::::: : : ::..:: :...::::: .. . . ::. .: . . :.... NP_705 WQASLQVRGRHICGGALIADRWVITAAHCFQEDSMASTVLWTVFLGKVWQNSRWPGEVSF 590 600 610 620 630 640 260 270 280 290 300 310 pF1KE6 GLRRIIVHEKYKHPSHDYDISLAELSSPVPYTNAVHRVCLPDASYEFQPGDVMFVTGFGA . :...: ... :::::..: .:. :: . ::. :::: :. :.:: ..::.:: NP_705 KVSRLLLHPYHEEDSHDYDVALLQLDHPVVRSAAVRPVCLPARSHFFEPGLHCWITGWGA 650 660 670 680 690 700 320 330 340 350 360 370 pF1KE6 LKNDGYSQNHLRQAQVTLIDATTCNEPQAYNDAITPRMLCAGSLEGKTDACQGDSGGPLV :.. : .: :....: :: :.: .: .:::::::: .:: :::::::::::: NP_705 LREGGPISNALQKVDVQLIPQDLCSE--VYRYQVTPRMLCAGYRKGKKDACQGDSGGPLV 710 720 730 740 750 760 380 390 400 410 420 pF1KE6 SSDARDIWYLAGIVSWGDECAKPNKPGVYTRVTALRDWITSKTGI . :.:::.:::: :..:: :::::.:.. .:: NP_705 CKALSGRWFLAGLVSWGLGCGRPNYFGVYTRITGVISWIQQVVT 770 780 790 800 810 >>NP_001243246 (OMIM: 605511) transmembrane protease ser (453 aa) initn: 660 init1: 322 opt: 693 Z-score: 782.3 bits: 153.9 E(85289): 7.8e-37 Smith-Waterman score: 693; 41.7% identity (65.5% similar) in 264 aa overlap (158-417:186-443) 130 140 150 160 170 180 pF1KE6 TEDPETVDKIVQLVLHEKLQDAVGPPKVDPHSVKIKKINKTETDSYLNHC--CGTRRSKT ::: ... . : .: :: :: NP_001 LRVSSLEGQFREEFVSIDHLLPDDKVTALHHSVYVREGCASGHVVTL-QCTACGHRR--- 160 170 180 190 200 210 190 200 210 220 230 240 pF1KE6 LGQSLRIVGGTEVEEGEWPWQASLQWDGSHRCGATLINATWLVSAAHCFTTYKNPARWTA : : :::::. ..::::::::..: : ::...:. :...:::: : :: NP_001 -GYSSRIVGGNMSLLSQWPWQASLQFQGYHLCGGSVITPLWIITAAHCVYDLYLPKSWTI 220 230 240 250 260 270 250 260 270 280 290 300 pF1KE6 SFG-VTIKPSKMKRGL-RRIIVHEKYKHPSHDYDISLAELSSPVPYTNAVHRVCLPDASY . : :.. . : ..:. : ::: ::.: .:..:. ... .. ::::.. NP_001 QVGLVSLLDNPAPSHLVEKIVYHSKYKPKRLGNDIALMKLAGPLTFNEMIQPVCLPNSEE 280 290 300 310 320 330 310 320 330 340 350 360 pF1KE6 EFQPGDVMFVTGFGALKNDGYSQNHLRQAQVTLIDATTCNEPQAYNDAITPRMLCAGSLE .: : : ...:.:: .. : .. : .: : ::. ::. ..:. :.: ::::: : NP_001 NFPDGKVCWTSGWGATEDGGDASPVLNHAAVPLISNKICNHRDVYGGIISPSMLCAGYLT 340 350 360 370 380 390 370 380 390 400 410 420 pF1KE6 GKTDACQGDSGGPLVSSDARDIWYLAGIVSWGDECAKPNKPGVYTRVTALRDWITSKTGI : .:.:::::::::: .. : .: :.: .:.: ::. ::::::::::.. ::: NP_001 GGVDSCQGDSGGPLVCQE-RRLWKLVGATSFGIGCAEVNKPGVYTRVTSFLDWIHEQMER 400 410 420 430 440 NP_001 DLKT 450 423 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 12:40:30 2016 done: Tue Nov 8 12:40:31 2016 Total Scan time: 6.570 Total Display time: 0.030 Function used was FASTA [36.3.4 Apr, 2011]