FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE4470, 492 aa 1>>>pF1KE4470 492 - 492 aa - 492 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.0879+/-0.000398; mu= 10.0275+/- 0.025 mean_var=133.4515+/-26.936, 0's: 0 Z-trim(116.4): 317 B-trim: 36 in 1/54 Lambda= 0.111023 statistics sampled from 27283 (27608) to 27283 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.687), E-opt: 0.2 (0.324), width: 16 Scan time: 8.700 The best scores are: opt bits E(85289) XP_011528033 (OMIM: 602060) PREDICTED: transmembra ( 492) 3494 571.3 2.1e-162 NP_005647 (OMIM: 602060) transmembrane protease se ( 492) 3494 571.3 2.1e-162 NP_001128571 (OMIM: 602060) transmembrane protease ( 529) 3494 571.4 2.2e-162 XP_011528034 (OMIM: 602060) PREDICTED: transmembra ( 410) 2781 457.1 4.4e-128 XP_011528035 (OMIM: 602060) PREDICTED: transmembra ( 384) 2747 451.6 1.8e-126 XP_005261100 (OMIM: 602060) PREDICTED: transmembra ( 452) 2431 401.1 3.5e-111 NP_001243246 (OMIM: 605511) transmembrane protease ( 453) 1191 202.4 2.2e-51 NP_076927 (OMIM: 605511) transmembrane protease se ( 454) 1180 200.7 7.4e-51 NP_001193718 (OMIM: 610050) transmembrane protease ( 532) 1000 171.9 4e-42 NP_001070731 (OMIM: 610050) transmembrane protease ( 567) 995 171.1 7.3e-42 NP_001231924 (OMIM: 610050) transmembrane protease ( 563) 993 170.8 9.1e-42 NP_115780 (OMIM: 605511) transmembrane protease se ( 327) 989 170.0 9.3e-42 NP_110397 (OMIM: 606751) transmembrane protease se ( 457) 907 157.0 1.1e-37 NP_001275680 (OMIM: 606751) transmembrane protease ( 448) 905 156.6 1.3e-37 NP_002763 (OMIM: 226200,606635) enteropeptidase pr (1019) 900 156.1 4.4e-37 NP_001275679 (OMIM: 606751) transmembrane protease ( 413) 893 154.7 4.7e-37 XP_011527961 (OMIM: 226200,606635) PREDICTED: ente (1034) 899 155.9 5e-37 XP_011527960 (OMIM: 226200,606635) PREDICTED: ente (1037) 899 155.9 5e-37 XP_011527959 (OMIM: 226200,606635) PREDICTED: ente (1049) 899 155.9 5.1e-37 XP_011527958 (OMIM: 226200,606635) PREDICTED: ente (1064) 899 155.9 5.1e-37 XP_011527956 (OMIM: 226200,606635) PREDICTED: ente (1064) 899 155.9 5.1e-37 XP_011527957 (OMIM: 226200,606635) PREDICTED: ente (1064) 899 155.9 5.1e-37 NP_001167023 (OMIM: 606565) transmembrane protease ( 397) 822 143.3 1.2e-33 NP_001277023 (OMIM: 606565) transmembrane protease ( 412) 822 143.3 1.3e-33 NP_001167022 (OMIM: 606565) transmembrane protease ( 435) 822 143.3 1.3e-33 NP_063947 (OMIM: 606565) transmembrane protease se ( 437) 822 143.3 1.3e-33 NP_001077416 (OMIM: 606565) transmembrane protease ( 432) 821 143.2 1.5e-33 NP_001265514 (OMIM: 605236,614595) atrial natriure ( 938) 824 143.9 1.9e-33 NP_006578 (OMIM: 605236,614595) atrial natriuretic (1042) 824 143.9 2.1e-33 XP_005271672 (OMIM: 606565) PREDICTED: transmembra ( 454) 805 140.6 8.9e-33 XP_011541204 (OMIM: 606565) PREDICTED: transmembra ( 456) 805 140.6 9e-33 XP_005271671 (OMIM: 606565) PREDICTED: transmembra ( 492) 805 140.6 9.5e-33 XP_005271670 (OMIM: 606565) PREDICTED: transmembra ( 494) 805 140.6 9.5e-33 XP_011541203 (OMIM: 606565) PREDICTED: transmembra ( 489) 801 140.0 1.5e-32 XP_016863673 (OMIM: 229000,612423) PREDICTED: plas ( 436) 767 134.5 5.9e-31 NP_001305325 (OMIM: 229000,612423) plasma kallikre ( 436) 767 134.5 5.9e-31 NP_001277025 (OMIM: 606565) transmembrane protease ( 290) 764 133.9 5.9e-31 NP_000883 (OMIM: 229000,612423) plasma kallikrein ( 638) 767 134.6 7.9e-31 XP_016863670 (OMIM: 229000,612423) PREDICTED: plas ( 649) 767 134.6 8e-31 XP_011530232 (OMIM: 229000,612423) PREDICTED: plas ( 649) 767 134.6 8e-31 XP_016882221 (OMIM: 142440) PREDICTED: serine prot ( 393) 747 131.3 5e-30 XP_016882220 (OMIM: 142440) PREDICTED: serine prot ( 417) 747 131.3 5.2e-30 XP_006723244 (OMIM: 142440) PREDICTED: serine prot ( 417) 747 131.3 5.2e-30 XP_005258895 (OMIM: 142440) PREDICTED: serine prot ( 417) 747 131.3 5.2e-30 NP_002142 (OMIM: 142440) serine protease hepsin pr ( 417) 747 131.3 5.2e-30 NP_892028 (OMIM: 142440) serine protease hepsin pr ( 417) 747 131.3 5.2e-30 XP_005265767 (OMIM: 605369) PREDICTED: transmembra ( 301) 711 125.4 2.2e-28 NP_068813 (OMIM: 606797) suppressor of tumorigenic ( 855) 717 126.7 2.6e-28 NP_004253 (OMIM: 605369) transmembrane protease se ( 418) 711 125.5 2.8e-28 NP_000119 (OMIM: 264900,612416) coagulation factor ( 625) 712 125.8 3.5e-28 >>XP_011528033 (OMIM: 602060) PREDICTED: transmembrane p (492 aa) initn: 3494 init1: 3494 opt: 3494 Z-score: 3036.6 bits: 571.3 E(85289): 2.1e-162 Smith-Waterman score: 3494; 100.0% identity (100.0% similar) in 492 aa overlap (1-492:1-492) 10 20 30 40 50 60 pF1KE4 MALNSGSPPAIGPYYENHGYQPENPYPAQPTVVPTVYEVHPAQYYPSPVPQYAPRVLTQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MALNSGSPPAIGPYYENHGYQPENPYPAQPTVVPTVYEVHPAQYYPSPVPQYAPRVLTQA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 SNPVVCTQPKSPSGTVCTSKTKKALCITLTLGTFLVGAALAAGLLWKFMGSKCSNSGIEC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SNPVVCTQPKSPSGTVCTSKTKKALCITLTLGTFLVGAALAAGLLWKFMGSKCSNSGIEC 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 DSSGTCINPSNWCDGVSHCPGGEDENRCVRLYGPNFILQVYSSQRKSWHPVCQDDWNENY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DSSGTCINPSNWCDGVSHCPGGEDENRCVRLYGPNFILQVYSSQRKSWHPVCQDDWNENY 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 GRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLNTSAGNVDIYKKLYHSDACSSKAVVSLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLNTSAGNVDIYKKLYHSDACSSKAVVSLR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 CIACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CIACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEK 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 PLNNPWHWTAFAGILRQSFMFYGAGYQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PLNNPWHWTAFAGILRQSFMFYGAGYQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 VKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLNAAKVLLIETQRCNSRYVYDNLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLNAAKVLLIETQRCNSRYVYDNLI 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE4 TPAMICAGFLQGNVDSCQGDSGGPLVTSKNNIWWLIGDTSWGSGCAKAYRPGVYGNVMVF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TPAMICAGFLQGNVDSCQGDSGGPLVTSKNNIWWLIGDTSWGSGCAKAYRPGVYGNVMVF 430 440 450 460 470 480 490 pF1KE4 TDWIYRQMRADG :::::::::::: XP_011 TDWIYRQMRADG 490 >>NP_005647 (OMIM: 602060) transmembrane protease serine (492 aa) initn: 3494 init1: 3494 opt: 3494 Z-score: 3036.6 bits: 571.3 E(85289): 2.1e-162 Smith-Waterman score: 3494; 100.0% identity (100.0% similar) in 492 aa overlap (1-492:1-492) 10 20 30 40 50 60 pF1KE4 MALNSGSPPAIGPYYENHGYQPENPYPAQPTVVPTVYEVHPAQYYPSPVPQYAPRVLTQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 MALNSGSPPAIGPYYENHGYQPENPYPAQPTVVPTVYEVHPAQYYPSPVPQYAPRVLTQA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 SNPVVCTQPKSPSGTVCTSKTKKALCITLTLGTFLVGAALAAGLLWKFMGSKCSNSGIEC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 SNPVVCTQPKSPSGTVCTSKTKKALCITLTLGTFLVGAALAAGLLWKFMGSKCSNSGIEC 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 DSSGTCINPSNWCDGVSHCPGGEDENRCVRLYGPNFILQVYSSQRKSWHPVCQDDWNENY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 DSSGTCINPSNWCDGVSHCPGGEDENRCVRLYGPNFILQVYSSQRKSWHPVCQDDWNENY 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 GRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLNTSAGNVDIYKKLYHSDACSSKAVVSLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 GRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLNTSAGNVDIYKKLYHSDACSSKAVVSLR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 CIACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 CIACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEK 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 PLNNPWHWTAFAGILRQSFMFYGAGYQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 PLNNPWHWTAFAGILRQSFMFYGAGYQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 VKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLNAAKVLLIETQRCNSRYVYDNLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 VKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLNAAKVLLIETQRCNSRYVYDNLI 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE4 TPAMICAGFLQGNVDSCQGDSGGPLVTSKNNIWWLIGDTSWGSGCAKAYRPGVYGNVMVF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 TPAMICAGFLQGNVDSCQGDSGGPLVTSKNNIWWLIGDTSWGSGCAKAYRPGVYGNVMVF 430 440 450 460 470 480 490 pF1KE4 TDWIYRQMRADG :::::::::::: NP_005 TDWIYRQMRADG 490 >>NP_001128571 (OMIM: 602060) transmembrane protease ser (529 aa) initn: 3494 init1: 3494 opt: 3494 Z-score: 3036.2 bits: 571.4 E(85289): 2.2e-162 Smith-Waterman score: 3494; 100.0% identity (100.0% similar) in 492 aa overlap (1-492:38-529) 10 20 30 pF1KE4 MALNSGSPPAIGPYYENHGYQPENPYPAQP :::::::::::::::::::::::::::::: NP_001 GESGCEERGAAGHIEHSRYLSLLDAVDNSKMALNSGSPPAIGPYYENHGYQPENPYPAQP 10 20 30 40 50 60 40 50 60 70 80 90 pF1KE4 TVVPTVYEVHPAQYYPSPVPQYAPRVLTQASNPVVCTQPKSPSGTVCTSKTKKALCITLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TVVPTVYEVHPAQYYPSPVPQYAPRVLTQASNPVVCTQPKSPSGTVCTSKTKKALCITLT 70 80 90 100 110 120 100 110 120 130 140 150 pF1KE4 LGTFLVGAALAAGLLWKFMGSKCSNSGIECDSSGTCINPSNWCDGVSHCPGGEDENRCVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LGTFLVGAALAAGLLWKFMGSKCSNSGIECDSSGTCINPSNWCDGVSHCPGGEDENRCVR 130 140 150 160 170 180 160 170 180 190 200 210 pF1KE4 LYGPNFILQVYSSQRKSWHPVCQDDWNENYGRAACRDMGYKNNFYSSQGIVDDSGSTSFM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LYGPNFILQVYSSQRKSWHPVCQDDWNENYGRAACRDMGYKNNFYSSQGIVDDSGSTSFM 190 200 210 220 230 240 220 230 240 250 260 270 pF1KE4 KLNTSAGNVDIYKKLYHSDACSSKAVVSLRCIACGVNLNSSRQSRIVGGESALPGAWPWQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KLNTSAGNVDIYKKLYHSDACSSKAVVSLRCIACGVNLNSSRQSRIVGGESALPGAWPWQ 250 260 270 280 290 300 280 290 300 310 320 330 pF1KE4 VSLHVQNVHVCGGSIITPEWIVTAAHCVEKPLNNPWHWTAFAGILRQSFMFYGAGYQVEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VSLHVQNVHVCGGSIITPEWIVTAAHCVEKPLNNPWHWTAFAGILRQSFMFYGAGYQVEK 310 320 330 340 350 360 340 350 360 370 380 390 pF1KE4 VISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEEK 370 380 390 400 410 420 400 410 420 430 440 450 pF1KE4 GKTSEVLNAAKVLLIETQRCNSRYVYDNLITPAMICAGFLQGNVDSCQGDSGGPLVTSKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GKTSEVLNAAKVLLIETQRCNSRYVYDNLITPAMICAGFLQGNVDSCQGDSGGPLVTSKN 430 440 450 460 470 480 460 470 480 490 pF1KE4 NIWWLIGDTSWGSGCAKAYRPGVYGNVMVFTDWIYRQMRADG :::::::::::::::::::::::::::::::::::::::::: NP_001 NIWWLIGDTSWGSGCAKAYRPGVYGNVMVFTDWIYRQMRADG 490 500 510 520 >>XP_011528034 (OMIM: 602060) PREDICTED: transmembrane p (410 aa) initn: 2781 init1: 2781 opt: 2781 Z-score: 2420.6 bits: 457.1 E(85289): 4.4e-128 Smith-Waterman score: 2781; 99.5% identity (99.5% similar) in 393 aa overlap (1-393:1-393) 10 20 30 40 50 60 pF1KE4 MALNSGSPPAIGPYYENHGYQPENPYPAQPTVVPTVYEVHPAQYYPSPVPQYAPRVLTQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MALNSGSPPAIGPYYENHGYQPENPYPAQPTVVPTVYEVHPAQYYPSPVPQYAPRVLTQA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 SNPVVCTQPKSPSGTVCTSKTKKALCITLTLGTFLVGAALAAGLLWKFMGSKCSNSGIEC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SNPVVCTQPKSPSGTVCTSKTKKALCITLTLGTFLVGAALAAGLLWKFMGSKCSNSGIEC 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 DSSGTCINPSNWCDGVSHCPGGEDENRCVRLYGPNFILQVYSSQRKSWHPVCQDDWNENY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DSSGTCINPSNWCDGVSHCPGGEDENRCVRLYGPNFILQVYSSQRKSWHPVCQDDWNENY 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 GRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLNTSAGNVDIYKKLYHSDACSSKAVVSLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLNTSAGNVDIYKKLYHSDACSSKAVVSLR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 CIACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CIACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEK 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 PLNNPWHWTAFAGILRQSFMFYGAGYQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PLNNPWHWTAFAGILRQSFMFYGAGYQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 VKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLNAAKVLLIETQRCNSRYVYDNLI :::::::::::::::::::::::::::::: : XP_011 VKPVCLPNPGMMLQPEQLCWISGWGATEEKDPTEPPMRERAFLGSAEPPQ 370 380 390 400 410 430 440 450 460 470 480 pF1KE4 TPAMICAGFLQGNVDSCQGDSGGPLVTSKNNIWWLIGDTSWGSGCAKAYRPGVYGNVMVF >>XP_011528035 (OMIM: 602060) PREDICTED: transmembrane p (384 aa) initn: 2747 init1: 2747 opt: 2747 Z-score: 2391.5 bits: 451.6 E(85289): 1.8e-126 Smith-Waterman score: 2747; 100.0% identity (100.0% similar) in 384 aa overlap (109-492:1-384) 80 90 100 110 120 130 pF1KE4 SKTKKALCITLTLGTFLVGAALAAGLLWKFMGSKCSNSGIECDSSGTCINPSNWCDGVSH :::::::::::::::::::::::::::::: XP_011 MGSKCSNSGIECDSSGTCINPSNWCDGVSH 10 20 30 140 150 160 170 180 190 pF1KE4 CPGGEDENRCVRLYGPNFILQVYSSQRKSWHPVCQDDWNENYGRAACRDMGYKNNFYSSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CPGGEDENRCVRLYGPNFILQVYSSQRKSWHPVCQDDWNENYGRAACRDMGYKNNFYSSQ 40 50 60 70 80 90 200 210 220 230 240 250 pF1KE4 GIVDDSGSTSFMKLNTSAGNVDIYKKLYHSDACSSKAVVSLRCIACGVNLNSSRQSRIVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GIVDDSGSTSFMKLNTSAGNVDIYKKLYHSDACSSKAVVSLRCIACGVNLNSSRQSRIVG 100 110 120 130 140 150 260 270 280 290 300 310 pF1KE4 GESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKPLNNPWHWTAFAGILRQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKPLNNPWHWTAFAGILRQS 160 170 180 190 200 210 320 330 340 350 360 370 pF1KE4 FMFYGAGYQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVCLPNPGMMLQPEQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FMFYGAGYQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVCLPNPGMMLQPEQL 220 230 240 250 260 270 380 390 400 410 420 430 pF1KE4 CWISGWGATEEKGKTSEVLNAAKVLLIETQRCNSRYVYDNLITPAMICAGFLQGNVDSCQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CWISGWGATEEKGKTSEVLNAAKVLLIETQRCNSRYVYDNLITPAMICAGFLQGNVDSCQ 280 290 300 310 320 330 440 450 460 470 480 490 pF1KE4 GDSGGPLVTSKNNIWWLIGDTSWGSGCAKAYRPGVYGNVMVFTDWIYRQMRADG :::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GDSGGPLVTSKNNIWWLIGDTSWGSGCAKAYRPGVYGNVMVFTDWIYRQMRADG 340 350 360 370 380 >>XP_005261100 (OMIM: 602060) PREDICTED: transmembrane p (452 aa) initn: 2431 init1: 2431 opt: 2431 Z-score: 2117.0 bits: 401.1 E(85289): 3.5e-111 Smith-Waterman score: 3087; 91.7% identity (91.9% similar) in 492 aa overlap (1-492:1-452) 10 20 30 40 50 60 pF1KE4 MALNSGSPPAIGPYYENHGYQPENPYPAQPTVVPTVYEVHPAQYYPSPVPQYAPRVLTQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MALNSGSPPAIGPYYENHGYQPENPYPAQPTVVPTVYEVHPAQYYPSPVPQYAPRVLTQA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 SNPVVCTQPKSPSGTVCTSKTKKALCITLTLGTFLVGAALAAGLLWKFMGSKCSNSGIEC :::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SNPVVCTQPKSPSGTVCTSKTKKALCITLTLGTFLVGAALAAGLLWKF------------ 70 80 90 100 130 140 150 160 170 180 pF1KE4 DSSGTCINPSNWCDGVSHCPGGEDENRCVRLYGPNFILQVYSSQRKSWHPVCQDDWNENY .::::::::::::::::::::::::::::::: XP_005 ----------------------------IRLYGPNFILQVYSSQRKSWHPVCQDDWNENY 110 120 130 140 190 200 210 220 230 240 pF1KE4 GRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLNTSAGNVDIYKKLYHSDACSSKAVVSLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLNTSAGNVDIYKKLYHSDACSSKAVVSLR 150 160 170 180 190 200 250 260 270 280 290 300 pF1KE4 CIACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 CIACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEK 210 220 230 240 250 260 310 320 330 340 350 360 pF1KE4 PLNNPWHWTAFAGILRQSFMFYGAGYQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PLNNPWHWTAFAGILRQSFMFYGAGYQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDL 270 280 290 300 310 320 370 380 390 400 410 420 pF1KE4 VKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLNAAKVLLIETQRCNSRYVYDNLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLNAAKVLLIETQRCNSRYVYDNLI 330 340 350 360 370 380 430 440 450 460 470 480 pF1KE4 TPAMICAGFLQGNVDSCQGDSGGPLVTSKNNIWWLIGDTSWGSGCAKAYRPGVYGNVMVF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TPAMICAGFLQGNVDSCQGDSGGPLVTSKNNIWWLIGDTSWGSGCAKAYRPGVYGNVMVF 390 400 410 420 430 440 490 pF1KE4 TDWIYRQMRADG :::::::::::: XP_005 TDWIYRQMRADG 450 >>NP_001243246 (OMIM: 605511) transmembrane protease ser (453 aa) initn: 1037 init1: 648 opt: 1191 Z-score: 1043.6 bits: 202.4 E(85289): 2.2e-51 Smith-Waterman score: 1191; 46.0% identity (68.4% similar) in 411 aa overlap (89-491:52-450) 60 70 80 90 100 110 pF1KE4 QASNPVVCTQPKSPSGTVCTSKTKKALCITLTLGTFLVGAALAAGLLWKFMGSKCSNSGI ...: . . ::: :: .: ::.. NP_001 DDLKISPVAPDADAVAAQILSLLPLKFFPIIVIGIIALILALAIGLGIHF---DCSGK-Y 30 40 50 60 70 120 130 140 150 160 170 pF1KE4 ECDSSGTCINPSNWCDGVSHCPGGEDENRCVRLYGPNFILQVYSSQRKSWHPVCQDDWNE .: :: ::. ::::: : :::: ::::. : : .:::... ::. .:.:::. NP_001 RCRSSFKCIELIARCDGVSDCKDGEDEYRCVRVGGQNAVLQVFTAA--SWKTMCSDDWKG 80 90 100 110 120 130 180 190 200 210 220 230 pF1KE4 NYGRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLNTSAGNV---DIYKKLYHS----DAC .:. .:: ..:. . . ::... .: .: . .: .. : :.:: ..: NP_001 HYANVACAQLGFPS-YVSSDNLRVSSLEGQFREEFVSIDHLLPDDKVTALHHSVYVREGC 140 150 160 170 180 190 240 250 260 270 280 290 pF1KE4 SSKAVVSLRCIACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWI .: ::.:.: ::: . : ::::::. .: . ::::.::. :. :.::::.::: :: NP_001 ASGHVVTLQCTACGHRRGYS--SRIVGGNMSLLSQWPWQASLQFQGYHLCGGSVITPLWI 200 210 220 230 240 250 300 310 320 330 340 350 pF1KE4 VTAAHCVEKPLNNPWHWTAFAGILRQSFMFYGA-GYQVEKVISHPNYDSKTKNNDIALMK .:::::: : : :: .:.. :.. : .. :::.. : .: : .::::::: NP_001 ITAAHCVYD-LYLPKSWTIQVGLV--SLLDNPAPSHLVEKIVYHSKYKPKRLGNDIALMK 260 270 280 290 300 360 370 380 390 400 410 pF1KE4 LQKPLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLNAAKVLLIETQRC : :::::....:::::: . ..:: :::::::. : .: ::: : : :: .. : NP_001 LAGPLTFNEMIQPVCLPNSEENFPDGKVCWTSGWGATEDGGDASPVLNHAAVPLISNKIC 310 320 330 340 350 360 420 430 440 450 460 470 pF1KE4 NSRYVYDNLITPAMICAGFLQGNVDSCQGDSGGPLVTSKNNIWWLIGDTSWGSGCAKAYR : : :: ..:.:.:.:::.: :.::::::::::::: .. .: :.: ::.: :::.. . NP_001 NHRDVYGGIISPSMLCAGYLTGGVDSCQGDSGGPLVCQERRLWKLVGATSFGIGCAEVNK 370 380 390 400 410 420 480 490 pF1KE4 PGVYGNVMVFTDWIYRQMRADG :::: : : :::..::. : NP_001 PGVYTRVTSFLDWIHEQMERDLKT 430 440 450 >>NP_076927 (OMIM: 605511) transmembrane protease serine (454 aa) initn: 1014 init1: 386 opt: 1180 Z-score: 1034.0 bits: 200.7 E(85289): 7.4e-51 Smith-Waterman score: 1180; 45.9% identity (68.2% similar) in 412 aa overlap (89-491:52-451) 60 70 80 90 100 110 pF1KE4 QASNPVVCTQPKSPSGTVCTSKTKKALCITLTLGTFLVGAALAAGLLWKFMGSKCSNSGI ...: . . ::: :: .: ::.. NP_076 DDLKISPVAPDADAVAAQILSLLPLKFFPIIVIGIIALILALAIGLGIHF---DCSGK-Y 30 40 50 60 70 120 130 140 150 160 170 pF1KE4 ECDSSGTCINPSNWCDGVSHCPGGEDENRCVRLYGPNFILQVYSSQRKSWHPVCQDDWNE .: :: ::. ::::: : :::: ::::. : : .:::... ::. .:.:::. NP_076 RCRSSFKCIELIARCDGVSDCKDGEDEYRCVRVGGQNAVLQVFTAA--SWKTMCSDDWKG 80 90 100 110 120 130 180 190 200 210 220 230 pF1KE4 NYGRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLNTSAGNV---DIYKKLYHS----DAC .:. .:: ..:. . . ::... .: .: . .: .. : :.:: ..: NP_076 HYANVACAQLGFPS-YVSSDNLRVSSLEGQFREEFVSIDHLLPDDKVTALHHSVYVREGC 140 150 160 170 180 190 240 250 260 270 280 290 pF1KE4 SSKAVVSLRCIACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWI .: ::.:.: ::: . : ::::::. .: . ::::.::. :. :.::::.::: :: NP_076 ASGHVVTLQCTACGHRRGYS--SRIVGGNMSLLSQWPWQASLQFQGYHLCGGSVITPLWI 200 210 220 230 240 250 300 310 320 330 340 350 pF1KE4 VTAAHCVEKPLNNPWHWTAFAGILRQSFMFYGA-GYQVEKVISHPNYDSKTKNNDIALMK .:::::: : : :: .:.. :.. : .. :::.. : .: : .::::::: NP_076 ITAAHCVYD-LYLPKSWTIQVGLV--SLLDNPAPSHLVEKIVYHSKYKPKRLGNDIALMK 260 270 280 290 300 360 370 380 390 400 pF1KE4 LQKPLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEE-KGKTSEVLNAAKVLLIETQR : :::::....:::::: . ..:: :::::::. : .: ::: : : :: .. NP_076 LAGPLTFNEMIQPVCLPNSEENFPDGKVCWTSGWGATEDGAGDASPVLNHAAVPLISNKI 310 320 330 340 350 360 410 420 430 440 450 460 pF1KE4 CNSRYVYDNLITPAMICAGFLQGNVDSCQGDSGGPLVTSKNNIWWLIGDTSWGSGCAKAY :: : :: ..:.:.:.:::.: :.::::::::::::: .. .: :.: ::.: :::.. NP_076 CNHRDVYGGIISPSMLCAGYLTGGVDSCQGDSGGPLVCQERRLWKLVGATSFGIGCAEVN 370 380 390 400 410 420 470 480 490 pF1KE4 RPGVYGNVMVFTDWIYRQMRADG .:::: : : :::..::. : NP_076 KPGVYTRVTSFLDWIHEQMERDLKT 430 440 450 >>NP_001193718 (OMIM: 610050) transmembrane protease ser (532 aa) initn: 866 init1: 497 opt: 1000 Z-score: 877.2 bits: 171.9 E(85289): 4e-42 Smith-Waterman score: 1006; 34.4% identity (62.1% similar) in 506 aa overlap (7-491:35-526) 10 20 30 pF1KE4 MALNSGSPPAIGPYYENH-GYQPENPYPAQ--PTVV :: .: . : : ::: :. . NP_001 SHGNASPARTPSAGASPAQASPAGTPPGRASPAQASPAQASPAGTPPGRASPAQASPAGT 10 20 30 40 50 60 40 50 60 70 80 pF1KE4 P----TVYEVHPAQYYPSPV-PQYAPRVLTQASNPVVCTQPKSPSGTVCTSKTKKALCIT : . .. ::: :. . : : .:.. : . .. :..: :: :. : . NP_001 PPGRASPGRASPAQASPAQASPARASPALASLSRSSSGRSSSARSASVTTSPTRVYLVRA 70 80 90 100 110 120 90 100 110 120 130 140 pF1KE4 LTLGTFLV--GAALAAGLLWKFMGSKCS----NSGIEC-DSSGTCINPSNWCDGVSHCPG .:. . . : .: : . ..::. .. .: . . :::: : NP_001 TPVGAVPIRSSPARSAPATRATRESPVQFWQGHTGIRYKEQRESCPKHAVRCDGVVDCKL 130 140 150 160 170 180 150 160 170 180 190 200 pF1KE4 GEDENRCVRLYGPNFILQVYSSQRKSWHPVCQDDWNENYGRAACRDMGYKNNFYSSQGIV :: :::. . .:..::.. ..: :.:...::..:.. .:...:... ... NP_001 KSDELGCVRFDWDKSLLKIYSGSSHQWLPICSSNWNDSYSEKTCQQLGFESAHRTTEVAH 190 200 210 220 230 240 210 220 230 240 250 260 pF1KE4 DD-SGSTSFMKLNTSAGNVDIYKKLYHSDACSSKAVVSLRCIACGVNLNSSRQSRIVGGE : ..: :... :.. : ..:..:. : :. .::.: ::. ..: :::: NP_001 RDFANSFSILRYNST-----IQESLHRSE-CPSQRYISLQCSHCGLRAMTGR---IVGGA 250 260 270 280 290 270 280 290 300 310 pF1KE4 SALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCV----EKPLNNPWHWTAFAGILR : . :::::::: ..:.:::..: .:..::::: :: :.. : ..:: NP_001 LASDSKWPWQVSLHFGTTHICGGTLIDAQWVLTAAHCFFVTREKVLEG---WKVYAG--T 300 310 320 330 340 350 320 330 340 350 360 370 pF1KE4 QSFMFYGAGYQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVCLPNPGMMLQPE ... . .. ..: . :: .. . :::::.:.::::.. ..:.::: :. .. . NP_001 SNLHQLPEAASIAEIIINSNYTDEEDDYDIALMRLSKPLTLSAHIHPACLPMHGQTFSLN 360 370 380 390 400 410 380 390 400 410 420 430 pF1KE4 QLCWISGWGATEEKG-KTSEVLNAAKVLLIETQRCNSRYVYDNLITPAMICAGFLQGNVD . :::.:.: :.: ::: : ..: ::. ..::. :::. .:: :.::: :.:. : NP_001 ETCWITGFGKTRETDDKTSPFLREVQVNLIDFKKCNDYLVYDSYLTPRMMCAGDLRGGRD 420 430 440 450 460 470 440 450 460 470 480 490 pF1KE4 SCQGDSGGPLVTSKNNIWWLIGDTSWGSGCAKAYRPGVYGNVMVFTDWIYRQMRADG ::::::::::: .:: :.: : ::::.::.. .:::: .: ::: .:... NP_001 SCQGDSGGPLVCEQNNRWYLAGVTSWGTGCGQRNKPGVYTKVTEVLPWIYSKMESEVRFR 480 490 500 510 520 530 NP_001 KS >>NP_001070731 (OMIM: 610050) transmembrane protease ser (567 aa) initn: 882 init1: 497 opt: 995 Z-score: 872.5 bits: 171.1 E(85289): 7.3e-42 Smith-Waterman score: 1009; 35.4% identity (63.4% similar) in 492 aa overlap (9-491:91-561) 10 20 30 pF1KE4 MALNSGSPPAIGPYYENHGYQPENPYPAQPTVVPT-VY ::.. .. . . . :. :. :: :: NP_001 PAGTPPGRASPGRASPAQASPAQASPARASPALASLSRSSSGRSSSARSASVTTSPTRVY 70 80 90 100 110 120 40 50 60 70 80 90 pF1KE4 EVHPAQYYPSPVPQYAPRVLTQASNPVVCTQPKSPSGTVCTSKTKKALCITLTL-GTFLV :. .:: : : :.. . .:: :: . : . : : : :. NP_001 LVR-----ATPVGAVPIRSSPARSAPATRATRESP-GTSLPKFTWREGQKQLPLIGCVLL 130 140 150 160 170 100 110 120 130 140 150 pF1KE4 GAALAAGLLWKFMGSKCSNSGIEC-DSSGTCINPSNWCDGVSHCPGGEDENRCVRLYGPN ::...:. :. . ...::. .. .: . . :::: : :: :::. . NP_001 LIALVVSLIILFQFWQ-GHTGIRYKEQRESCPKHAVRCDGVVDCKLKSDELGCVRFDWDK 180 190 200 210 220 230 160 170 180 190 200 210 pF1KE4 FILQVYSSQRKSWHPVCQDDWNENYGRAACRDMGYKNNFYSSQGIVDD-SGSTSFMKLNT .:..::.. ..: :.:...::..:.. .:...:... ... : ..: :... :. NP_001 SLLKIYSGSSHQWLPICSSNWNDSYSEKTCQQLGFESAHRTTEVAHRDFANSFSILRYNS 240 250 260 270 280 290 220 230 240 250 260 270 pF1KE4 SAGNVDIYKKLYHSDACSSKAVVSLRCIACGVNLNSSRQSRIVGGESALPGAWPWQVSLH . : ..:..:. : :. .::.: ::. . .::::: : . :::::::: NP_001 T-----IQESLHRSE-CPSQRYISLQCSHCGL---RAMTGRIVGGALASDSKWPWQVSLH 300 310 320 330 340 280 290 300 310 320 330 pF1KE4 VQNVHVCGGSIITPEWIVTAAHCV----EKPLNNPWHWTAFAGILRQSFMFYGAGYQVEK ..:.:::..: .:..::::: :: :.. : ..:: . .:. . . NP_001 FGTTHICGGTLIDAQWVLTAAHCFFVTREKVLEG---WKVYAGTSNLHQLPEAAS--IAE 350 360 370 380 390 340 350 360 370 380 390 pF1KE4 VISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEEK .: . :: .. . :::::.:.::::.. ..:.::: :. .. .. :::.:.: :.: NP_001 IIINSNYTDEEDDYDIALMRLSKPLTLSAHIHPACLPMHGQTFSLNETCWITGFGKTRET 400 410 420 430 440 450 400 410 420 430 440 pF1KE4 G-KTSEVLNAAKVLLIETQRCNSRYVYDNLITPAMICAGFLQGNVDSCQGDSGGPLVTSK ::: : ..: ::. ..::. :::. .:: :.::: :.:. :::::::::::: . NP_001 DDKTSPFLREVQVNLIDFKKCNDYLVYDSYLTPRMMCAGDLRGGRDSCQGDSGGPLVCEQ 460 470 480 490 500 510 450 460 470 480 490 pF1KE4 NNIWWLIGDTSWGSGCAKAYRPGVYGNVMVFTDWIYRQMRADG :: :.: : ::::.::.. .:::: .: ::: .:... NP_001 NNRWYLAGVTSWGTGCGQRNKPGVYTKVTEVLPWIYSKMESEVRFRKS 520 530 540 550 560 492 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 00:54:41 2016 done: Sun Nov 6 00:54:43 2016 Total Scan time: 8.700 Total Display time: 0.090 Function used was FASTA [36.3.4 Apr, 2011]