FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE6751, 593 aa 1>>>pF1KE6751 593 - 593 aa - 593 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.7009+/-0.000357; mu= 22.7200+/- 0.022 mean_var=71.2277+/-14.210, 0's: 0 Z-trim(114.0): 36 B-trim: 169 in 2/50 Lambda= 0.151967 statistics sampled from 23596 (23625) to 23596 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.647), E-opt: 0.2 (0.277), width: 16 Scan time: 7.940 The best scores are: opt bits E(85289) NP_612404 (OMIM: 609728,611390,616430) methionine- ( 593) 4124 913.7 0 XP_006719461 (OMIM: 156560,615486,616280) PREDICTE ( 666) 205 54.5 1.3e-06 NP_004981 (OMIM: 156560,615486,616280) methionine- ( 900) 205 54.7 1.6e-06 XP_016866735 (OMIM: 192150) PREDICTED: valine--tRN ( 682) 153 43.1 0.0035 XP_016866736 (OMIM: 192150) PREDICTED: valine--tRN ( 682) 153 43.1 0.0035 NP_006286 (OMIM: 192150) valine--tRNA ligase [Homo (1264) 153 43.4 0.0055 XP_005249419 (OMIM: 192150) PREDICTED: valine--tRN (1265) 153 43.4 0.0055 >>NP_612404 (OMIM: 609728,611390,616430) methionine--tRN (593 aa) initn: 4124 init1: 4124 opt: 4124 Z-score: 4884.0 bits: 913.7 E(85289): 0 Smith-Waterman score: 4124; 100.0% identity (100.0% similar) in 593 aa overlap (1-593:1-593) 10 20 30 40 50 60 pF1KE6 MLRTSVLRLLGRTGASRLSLLEDFGPRYYSSGSLSAGDDACDVRAYFTTPIFYVNAAPHI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_612 MLRTSVLRLLGRTGASRLSLLEDFGPRYYSSGSLSAGDDACDVRAYFTTPIFYVNAAPHI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 GHLYSALLADALCRHRRLRGPSTAATRFSTGTDEHGLKIQQAAATAGLAPTELCDRVSEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_612 GHLYSALLADALCRHRRLRGPSTAATRFSTGTDEHGLKIQQAAATAGLAPTELCDRVSEQ 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 FQQLFQEAGISCTDFIRTTEARHRVAVQHFWGVLKSRGLLYKGVYEGWYCASDECFLPEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_612 FQQLFQEAGISCTDFIRTTEARHRVAVQHFWGVLKSRGLLYKGVYEGWYCASDECFLPEA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 KVTQQPGPSGDSFPVSLESGHPVSWTKEENYIFRLSQFRKPLQRWLRGNPQAITPEPFHH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_612 KVTQQPGPSGDSFPVSLESGHPVSWTKEENYIFRLSQFRKPLQRWLRGNPQAITPEPFHH 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE6 VVLQWLDEELPDLSVSRRSSHLHWGIPVPGDDSQTIYVWLDALVNYLTVIGYPNAEFKSW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_612 VVLQWLDEELPDLSVSRRSSHLHWGIPVPGDDSQTIYVWLDALVNYLTVIGYPNAEFKSW 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE6 WPATSHIIGKDILKFHAIYWPAFLLGAGMSPPQRICVHSHWTVCGQKMSKSLGNVVDPRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_612 WPATSHIIGKDILKFHAIYWPAFLLGAGMSPPQRICVHSHWTVCGQKMSKSLGNVVDPRT 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE6 CLNRYTVDGFRYFLLRQGVPNWDCDYYDEKVVKLLNSELADALGGLLNRCTAKRINPSET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_612 CLNRYTVDGFRYFLLRQGVPNWDCDYYDEKVVKLLNSELADALGGLLNRCTAKRINPSET 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE6 YPAFCTTCFPSEPGLVGPSVRAQAEDYALVSAVATLPKQVADHYDNFRIYKALEAVSSCV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_612 YPAFCTTCFPSEPGLVGPSVRAQAEDYALVSAVATLPKQVADHYDNFRIYKALEAVSSCV 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE6 RQTNGFVQRHAPWKLNWESPVDAPWLGTVLHVALECLRVFGTLLQPVTPSLADKLLSRLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_612 RQTNGFVQRHAPWKLNWESPVDAPWLGTVLHVALECLRVFGTLLQPVTPSLADKLLSRLG 490 500 510 520 530 540 550 560 570 580 590 pF1KE6 VSASERSLGELYFLPRFYGHPCPFEGRRLGPETGLLFPRLDQSRTWLVKAHRT ::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_612 VSASERSLGELYFLPRFYGHPCPFEGRRLGPETGLLFPRLDQSRTWLVKAHRT 550 560 570 580 590 >>XP_006719461 (OMIM: 156560,615486,616280) PREDICTED: m (666 aa) initn: 488 init1: 137 opt: 205 Z-score: 239.8 bits: 54.5 E(85289): 1.3e-06 Smith-Waterman score: 493; 24.8% identity (51.7% similar) in 572 aa overlap (48-584:35-575) 20 30 40 50 60 70 pF1KE6 LSLLEDFGPRYYSSGSLSAGDDACDVRAYFTTPIFYVNAAPHIGHLYSALL-ADALCRHR :. . ::: .::.:.. . .: ::.. :. XP_006 AWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYS 10 20 30 40 50 60 80 90 100 110 120 130 pF1KE6 RLRGPSTAATRFSTGTDEHGLKIQQAAATAGLAPTELCDRVSEQFQQLFQEAGISCTDFI ::: .: . ::::.: . : ::.: :.::. .... .:: : XP_006 RLRQWNTL---YLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFG 70 80 90 100 110 120 140 150 160 170 180 pF1KE6 RTTEARHRVAVQHFWGVLKSRGLLYKGVYEGWYCASDECFL---------PEAKVTQQPG ::: .. .: .. : .::.. . . : : :: : . : XP_006 RTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARG 130 140 150 160 170 180 190 200 210 220 230 pF1KE6 PSGDSF-----PVSLESGH-------PVSWTKEENYIFRLSQFRKPLQRWL-RGNPQA-I . :. : :.. . :: .... .. : ...: :..:: : : . XP_006 DQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFL-DLPKLEKRLEEWLGRTLPGSDW 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE6 TPEPFHHVVLQWLDEELPDLSVSRRSSHLHWGIPVP--GDDSQTIYVWLDALVNYLTVIG ::. . .. .:: . : ..: :.:: ::: : .....:::.:: ..::.. . XP_006 TPNA-QFITRSWLRDGLKPRCITR---DLKWGTPVPLEGFEDKVFYVWFDATIGYLSITA 250 260 270 280 290 300 310 320 330 340 pF1KE6 YPNAEFKSWWPATSHI-----IGKDILKFHAIYWPAFLLGA--GMSPPQRICVHSHWTVC . ... :: .. ..:: . ::.. .: ::: ... ... . . . XP_006 NYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYE 300 310 320 330 340 350 350 360 370 380 390 400 pF1KE6 GQKMSKSLG-NVVDPRTCLNRYTVDGFRYFLLRQGVPNWDCDYYDEKVVKLLNSELADAL :.::: : .: . . .: .:..:: . : . .. :::: . : XP_006 DGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNL 360 370 380 390 400 410 410 420 430 440 450 460 pF1KE6 GGLLNRCTAKRINPSETYPAFCTTCFPSEPGLVGPSVRAQAEDYALVSAVATLPKQVADH :...:: : . : : : : . .: :.. :. .. . XP_006 GNFINRAGM-----------FVSKFF---GGYV-PEMVLTPDDQRLLAHVTLELQHYHQL 420 430 440 450 460 470 480 490 500 510 520 pF1KE6 YDNFRIYKALEAVSSCVRQTNGFVQRHAPWKLNWESPVDAPWLGTVLHVALECLRVFGTL .. :: ::... . :. : ..: . ::: : .: ::: .:.. ..... XP_006 LEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVM 470 480 490 500 510 520 530 540 550 560 570 580 pF1KE6 LQPVTPSLADKLLSRLGVSASERSLGELYFLPRFYGHPCPFE-GRRLGPETGLLFPRLDQ ::: :... . ..: . :. :: : . :...: . : : .:.. XP_006 LQPYMPTVSATIQAQLQLPPPACSILLTNFL-------CTLPAGHQIGTVSPL-FQKLEN 530 540 550 560 570 590 pF1KE6 SRTWLVKAHRT .. XP_006 DQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKN 580 590 600 610 620 630 >>NP_004981 (OMIM: 156560,615486,616280) methionine--tRN (900 aa) initn: 488 init1: 137 opt: 205 Z-score: 238.1 bits: 54.7 E(85289): 1.6e-06 Smith-Waterman score: 493; 24.8% identity (51.7% similar) in 572 aa overlap (48-584:269-809) 20 30 40 50 60 70 pF1KE6 LSLLEDFGPRYYSSGSLSAGDDACDVRAYFTTPIFYVNAAPHIGHLYSALL-ADALCRHR :. . ::: .::.:.. . .: ::.. :. NP_004 AWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYS 240 250 260 270 280 290 80 90 100 110 120 130 pF1KE6 RLRGPSTAATRFSTGTDEHGLKIQQAAATAGLAPTELCDRVSEQFQQLFQEAGISCTDFI ::: .: . ::::.: . : ::.: :.::. .... .:: : NP_004 RLRQWNTL---YLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFG 300 310 320 330 340 350 140 150 160 170 180 pF1KE6 RTTEARHRVAVQHFWGVLKSRGLLYKGVYEGWYCASDECFL---------PEAKVTQQPG ::: .. .: .. : .::.. . . : : :: : . : NP_004 RTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARG 360 370 380 390 400 410 190 200 210 220 230 pF1KE6 PSGDSF-----PVSLESGH-------PVSWTKEENYIFRLSQFRKPLQRWL-RGNPQA-I . :. : :.. . :: .... .. : ...: :..:: : : . NP_004 DQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFL-DLPKLEKRLEEWLGRTLPGSDW 420 430 440 450 460 470 240 250 260 270 280 290 pF1KE6 TPEPFHHVVLQWLDEELPDLSVSRRSSHLHWGIPVP--GDDSQTIYVWLDALVNYLTVIG ::. . .. .:: . : ..: :.:: ::: : .....:::.:: ..::.. . NP_004 TPNA-QFITRSWLRDGLKPRCITR---DLKWGTPVPLEGFEDKVFYVWFDATIGYLSITA 480 490 500 510 520 530 300 310 320 330 340 pF1KE6 YPNAEFKSWWPATSHI-----IGKDILKFHAIYWPAFLLGA--GMSPPQRICVHSHWTVC . ... :: .. ..:: . ::.. .: ::: ... ... . . . NP_004 NYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYE 540 550 560 570 580 590 350 360 370 380 390 400 pF1KE6 GQKMSKSLG-NVVDPRTCLNRYTVDGFRYFLLRQGVPNWDCDYYDEKVVKLLNSELADAL :.::: : .: . . .: .:..:: . : . .. :::: . : NP_004 DGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNL 600 610 620 630 640 650 410 420 430 440 450 460 pF1KE6 GGLLNRCTAKRINPSETYPAFCTTCFPSEPGLVGPSVRAQAEDYALVSAVATLPKQVADH :...:: : . : : : : . .: :.. :. .. . NP_004 GNFINRAGM-----------FVSKFF---GGYV-PEMVLTPDDQRLLAHVTLELQHYHQL 660 670 680 690 470 480 490 500 510 520 pF1KE6 YDNFRIYKALEAVSSCVRQTNGFVQRHAPWKLNWESPVDAPWLGTVLHVALECLRVFGTL .. :: ::... . :. : ..: . ::: : .: ::: .:.. ..... NP_004 LEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVM 700 710 720 730 740 750 530 540 550 560 570 580 pF1KE6 LQPVTPSLADKLLSRLGVSASERSLGELYFLPRFYGHPCPFE-GRRLGPETGLLFPRLDQ ::: :... . ..: . :. :: : . :...: . : : .:.. NP_004 LQPYMPTVSATIQAQLQLPPPACSILLTNFL-------CTLPAGHQIGTVSPL-FQKLEN 760 770 780 790 800 590 pF1KE6 SRTWLVKAHRT .. NP_004 DQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKN 810 820 830 840 850 860 >>XP_016866735 (OMIM: 192150) PREDICTED: valine--tRNA li (682 aa) initn: 137 init1: 92 opt: 153 Z-score: 178.0 bits: 43.1 E(85289): 0.0035 Smith-Waterman score: 153; 31.2% identity (60.7% similar) in 112 aa overlap (272-375:201-308) 250 260 270 280 290 pF1KE6 VLQWLDEELPDLSVSRRSSHLHWGIPVPGDDSQTIYVWLDALVNYLTVIGYPNA--EFKS : ... .:... . :...:.:: ... XP_016 YWVSGRNEAEAREKAAKEFGVSPDKISLQQDEDVLDTWFSSGLFPLSILGWPNQSEDLSV 180 190 200 210 220 230 300 310 320 330 340 350 pF1KE6 WWPATSHIIGKDILKFHAIYWPAFLLGAGMSPPQRI---CVHSHWTV---CGQKMSKSLG ..:.: :.::: : : : .. :.. :. :. : : :.::::::: XP_016 FYPGTLLETGHDILFF----WVARMVMLGLKLTGRLPFREVYLHAIVRDAHGRKMSKSLG 240 250 260 270 280 360 370 380 390 400 410 pF1KE6 NVVDPRTCLNRYTVDGFRYFLLRQGVPNWDCDYYDEKVVKLLNSELADALGGLLNRCTAK ::.:: . ...:.. :: XP_016 NVIDPLDVIYGISLQGLHNQLLNSNLDPSEVEKAKEGQKADFPAGIPECGTDALRFGLCA 290 300 310 320 330 340 >>XP_016866736 (OMIM: 192150) PREDICTED: valine--tRNA li (682 aa) initn: 137 init1: 92 opt: 153 Z-score: 178.0 bits: 43.1 E(85289): 0.0035 Smith-Waterman score: 153; 31.2% identity (60.7% similar) in 112 aa overlap (272-375:201-308) 250 260 270 280 290 pF1KE6 VLQWLDEELPDLSVSRRSSHLHWGIPVPGDDSQTIYVWLDALVNYLTVIGYPNA--EFKS : ... .:... . :...:.:: ... XP_016 YWVSGRNEAEAREKAAKEFGVSPDKISLQQDEDVLDTWFSSGLFPLSILGWPNQSEDLSV 180 190 200 210 220 230 300 310 320 330 340 350 pF1KE6 WWPATSHIIGKDILKFHAIYWPAFLLGAGMSPPQRI---CVHSHWTV---CGQKMSKSLG ..:.: :.::: : : : .. :.. :. :. : : :.::::::: XP_016 FYPGTLLETGHDILFF----WVARMVMLGLKLTGRLPFREVYLHAIVRDAHGRKMSKSLG 240 250 260 270 280 360 370 380 390 400 410 pF1KE6 NVVDPRTCLNRYTVDGFRYFLLRQGVPNWDCDYYDEKVVKLLNSELADALGGLLNRCTAK ::.:: . ...:.. :: XP_016 NVIDPLDVIYGISLQGLHNQLLNSNLDPSEVEKAKEGQKADFPAGIPECGTDALRFGLCA 290 300 310 320 330 340 >>NP_006286 (OMIM: 192150) valine--tRNA ligase [Homo sap (1264 aa) initn: 168 init1: 92 opt: 153 Z-score: 174.6 bits: 43.4 E(85289): 0.0055 Smith-Waterman score: 153; 31.2% identity (60.7% similar) in 112 aa overlap (272-375:783-890) 250 260 270 280 290 pF1KE6 VLQWLDEELPDLSVSRRSSHLHWGIPVPGDDSQTIYVWLDALVNYLTVIGYPNA--EFKS : ... .:... . :...:.:: ... NP_006 YWVSGRNEAEAREKAAKEFGVSPDKISLQQDEDVLDTWFSSGLFPLSILGWPNQSEDLSV 760 770 780 790 800 810 300 310 320 330 340 350 pF1KE6 WWPATSHIIGKDILKFHAIYWPAFLLGAGMSPPQRI---CVHSHWTV---CGQKMSKSLG ..:.: :.::: : : : .. :.. :. :. : : :.::::::: NP_006 FYPGTLLETGHDILFF----WVARMVMLGLKLTGRLPFREVYLHAIVRDAHGRKMSKSLG 820 830 840 850 860 360 370 380 390 400 410 pF1KE6 NVVDPRTCLNRYTVDGFRYFLLRQGVPNWDCDYYDEKVVKLLNSELADALGGLLNRCTAK ::.:: . ...:.. :: NP_006 NVIDPLDVIYGISLQGLHNQLLNSNLDPSEVEKAKEGQKADFPAGIPECGTDALRFGLCA 870 880 890 900 910 920 >>XP_005249419 (OMIM: 192150) PREDICTED: valine--tRNA li (1265 aa) initn: 168 init1: 92 opt: 153 Z-score: 174.6 bits: 43.4 E(85289): 0.0055 Smith-Waterman score: 153; 31.2% identity (60.7% similar) in 112 aa overlap (272-375:784-891) 250 260 270 280 290 pF1KE6 VLQWLDEELPDLSVSRRSSHLHWGIPVPGDDSQTIYVWLDALVNYLTVIGYPNA--EFKS : ... .:... . :...:.:: ... XP_005 YWVSGRNEAEAREKAAKEFGVSPDKISLQQDEDVLDTWFSSGLFPLSILGWPNQSEDLSV 760 770 780 790 800 810 300 310 320 330 340 350 pF1KE6 WWPATSHIIGKDILKFHAIYWPAFLLGAGMSPPQRI---CVHSHWTV---CGQKMSKSLG ..:.: :.::: : : : .. :.. :. :. : : :.::::::: XP_005 FYPGTLLETGHDILFF----WVARMVMLGLKLTGRLPFREVYLHAIVRDAHGRKMSKSLG 820 830 840 850 860 360 370 380 390 400 410 pF1KE6 NVVDPRTCLNRYTVDGFRYFLLRQGVPNWDCDYYDEKVVKLLNSELADALGGLLNRCTAK ::.:: . ...:.. :: XP_005 NVIDPLDVIYGISLQGLHNQLLNSNLDPSEVEKAKEGQKADFPAGIPECGTDALRFGLCA 870 880 890 900 910 920 593 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 16:01:19 2016 done: Tue Nov 8 16:01:20 2016 Total Scan time: 7.940 Total Display time: 0.030 Function used was FASTA [36.3.4 Apr, 2011]