FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE3689, 685 aa 1>>>pF1KE3689 685 - 685 aa - 685 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.0256+/-0.000523; mu= 17.5959+/- 0.032 mean_var=152.7310+/-32.168, 0's: 0 Z-trim(112.3): 155 B-trim: 0 in 0/50 Lambda= 0.103779 statistics sampled from 21064 (21244) to 21064 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.603), E-opt: 0.2 (0.249), width: 16 Scan time: 9.990 The best scores are: opt bits E(85289) NP_005658 (OMIM: 602507) E3 ubiquitin-protein liga ( 685) 4731 721.5 2.6e-207 NP_001185880 (OMIM: 602507) E3 ubiquitin-protein l ( 681) 4601 702.0 1.9e-201 NP_001185881 (OMIM: 602507) E3 ubiquitin-protein l ( 122) 789 130.4 4.1e-30 XP_016879917 (OMIM: 610431) PREDICTED: E3 ubiquiti ( 227) 187 40.6 0.0082 XP_016869786 (OMIM: 612488) PREDICTED: E3 ubiquiti ( 402) 189 41.2 0.0095 XP_016869785 (OMIM: 612488) PREDICTED: E3 ubiquiti ( 402) 189 41.2 0.0095 XP_006716784 (OMIM: 612488) PREDICTED: E3 ubiquiti ( 432) 189 41.2 0.01 NP_919313 (OMIM: 612488) E3 ubiquitin-protein liga ( 432) 189 41.2 0.01 XP_005251425 (OMIM: 612488) PREDICTED: E3 ubiquiti ( 432) 189 41.2 0.01 XP_005251423 (OMIM: 612488) PREDICTED: E3 ubiquiti ( 432) 189 41.2 0.01 XP_005251424 (OMIM: 612488) PREDICTED: E3 ubiquiti ( 432) 189 41.2 0.01 XP_011516014 (OMIM: 612488) PREDICTED: E3 ubiquiti ( 432) 189 41.2 0.01 XP_011516015 (OMIM: 612488) PREDICTED: E3 ubiquiti ( 432) 189 41.2 0.01 NP_919309 (OMIM: 612488) E3 ubiquitin-protein liga ( 432) 189 41.2 0.01 XP_016869784 (OMIM: 612488) PREDICTED: E3 ubiquiti ( 432) 189 41.2 0.01 NP_919311 (OMIM: 612488) E3 ubiquitin-protein liga ( 432) 189 41.2 0.01 >>NP_005658 (OMIM: 602507) E3 ubiquitin-protein ligase R (685 aa) initn: 4731 init1: 4731 opt: 4731 Z-score: 3842.9 bits: 721.5 E(85289): 2.6e-207 Smith-Waterman score: 4731; 100.0% identity (100.0% similar) in 685 aa overlap (1-685:1-685) 10 20 30 40 50 60 pF1KE3 MWLKLFFLLLYFLVLFVLARFFEAIVWYETGIFATQLVDPVALSFKKLKTILECRGLGYS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 MWLKLFFLLLYFLVLFVLARFFEAIVWYETGIFATQLVDPVALSFKKLKTILECRGLGYS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 GLPEKKDVRELVEKSGDLMEGELYSALKEEEASESVSSTNFSGEMHFYELVEDTKDGIWL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 GLPEKKDVRELVEKSGDLMEGELYSALKEEEASESVSSTNFSGEMHFYELVEDTKDGIWL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 VQVIANDRSPLVGKIHWEKMVKKVSRFGIRTGTFNCSSDPRYCRRRGWVRSTLIMSVPQT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 VQVIANDRSPLVGKIHWEKMVKKVSRFGIRTGTFNCSSDPRYCRRRGWVRSTLIMSVPQT 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 STSKGKVMLKEYSGRKIEVEHIFKWITAHAASRIKTIYNAEHLKEEWNKSDQYWLKIYLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 STSKGKVMLKEYSGRKIEVEHIFKWITAHAASRIKTIYNAEHLKEEWNKSDQYWLKIYLF 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 ANLDQPPAFFSALSIKFTGRVEFIFVNVENWDNKSYMTDIGIYNMPSYILRTPEGIYRYG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 ANLDQPPAFFSALSIKFTGRVEFIFVNVENWDNKSYMTDIGIYNMPSYILRTPEGIYRYG 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 NHTGEFISLQAMDSFLRSLQPEVNDLFVLSLVLVNLMAWMDLFITQGATIKRFVVLISTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 NHTGEFISLQAMDSFLRSLQPEVNDLFVLSLVLVNLMAWMDLFITQGATIKRFVVLISTL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE3 GTYNSLLIISWLPVLGFLQLPYLDSFYEYSLKLLRYSNTTTLASWVRADWMFYSSHPALF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 GTYNSLLIISWLPVLGFLQLPYLDSFYEYSLKLLRYSNTTTLASWVRADWMFYSSHPALF 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE3 LSTYLGHGLLIDYFEKKRRRNNNNDEVNANNLEWLSSLWDWYTSYLFHPIASFQNFPVES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 LSTYLGHGLLIDYFEKKRRRNNNNDEVNANNLEWLSSLWDWYTSYLFHPIASFQNFPVES 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE3 DWDEDPDLFLERLAFPDLWLHPLIPTDYIKNLPMWRFKCLGVQSEEEMSEGSQDTENDSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 DWDEDPDLFLERLAFPDLWLHPLIPTDYIKNLPMWRFKCLGVQSEEEMSEGSQDTENDSE 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE3 SENTDTLSSEKEVFEDKQSVLHNSPGTASHCDAEACSCANKYCQTSPCERKGRSYGSYNT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 SENTDTLSSEKEVFEDKQSVLHNSPGTASHCDAEACSCANKYCQTSPCERKGRSYGSYNT 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE3 NEDMEPDWLTWPADMLHCTECVVCLENFENGCLLMGLPCGHVFHQNCIVMWLAGGRHCCP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 NEDMEPDWLTWPADMLHCTECVVCLENFENGCLLMGLPCGHVFHQNCIVMWLAGGRHCCP 610 620 630 640 650 660 670 680 pF1KE3 VCRWPSYKKKQPYAQHQPLSNDVPS ::::::::::::::::::::::::: NP_005 VCRWPSYKKKQPYAQHQPLSNDVPS 670 680 >>NP_001185880 (OMIM: 602507) E3 ubiquitin-protein ligas (681 aa) initn: 4601 init1: 4601 opt: 4601 Z-score: 3737.8 bits: 702.0 E(85289): 1.9e-201 Smith-Waterman score: 4601; 100.0% identity (100.0% similar) in 665 aa overlap (21-685:17-681) 10 20 30 40 50 60 pF1KE3 MWLKLFFLLLYFLVLFVLARFFEAIVWYETGIFATQLVDPVALSFKKLKTILECRGLGYS :::::::::::::::::::::::::::::::::::::::: NP_001 MSRLRPRPPLIHGCGGFFEAIVWYETGIFATQLVDPVALSFKKLKTILECRGLGYS 10 20 30 40 50 70 80 90 100 110 120 pF1KE3 GLPEKKDVRELVEKSGDLMEGELYSALKEEEASESVSSTNFSGEMHFYELVEDTKDGIWL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GLPEKKDVRELVEKSGDLMEGELYSALKEEEASESVSSTNFSGEMHFYELVEDTKDGIWL 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE3 VQVIANDRSPLVGKIHWEKMVKKVSRFGIRTGTFNCSSDPRYCRRRGWVRSTLIMSVPQT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VQVIANDRSPLVGKIHWEKMVKKVSRFGIRTGTFNCSSDPRYCRRRGWVRSTLIMSVPQT 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE3 STSKGKVMLKEYSGRKIEVEHIFKWITAHAASRIKTIYNAEHLKEEWNKSDQYWLKIYLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 STSKGKVMLKEYSGRKIEVEHIFKWITAHAASRIKTIYNAEHLKEEWNKSDQYWLKIYLF 180 190 200 210 220 230 250 260 270 280 290 300 pF1KE3 ANLDQPPAFFSALSIKFTGRVEFIFVNVENWDNKSYMTDIGIYNMPSYILRTPEGIYRYG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ANLDQPPAFFSALSIKFTGRVEFIFVNVENWDNKSYMTDIGIYNMPSYILRTPEGIYRYG 240 250 260 270 280 290 310 320 330 340 350 360 pF1KE3 NHTGEFISLQAMDSFLRSLQPEVNDLFVLSLVLVNLMAWMDLFITQGATIKRFVVLISTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NHTGEFISLQAMDSFLRSLQPEVNDLFVLSLVLVNLMAWMDLFITQGATIKRFVVLISTL 300 310 320 330 340 350 370 380 390 400 410 420 pF1KE3 GTYNSLLIISWLPVLGFLQLPYLDSFYEYSLKLLRYSNTTTLASWVRADWMFYSSHPALF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GTYNSLLIISWLPVLGFLQLPYLDSFYEYSLKLLRYSNTTTLASWVRADWMFYSSHPALF 360 370 380 390 400 410 430 440 450 460 470 480 pF1KE3 LSTYLGHGLLIDYFEKKRRRNNNNDEVNANNLEWLSSLWDWYTSYLFHPIASFQNFPVES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LSTYLGHGLLIDYFEKKRRRNNNNDEVNANNLEWLSSLWDWYTSYLFHPIASFQNFPVES 420 430 440 450 460 470 490 500 510 520 530 540 pF1KE3 DWDEDPDLFLERLAFPDLWLHPLIPTDYIKNLPMWRFKCLGVQSEEEMSEGSQDTENDSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DWDEDPDLFLERLAFPDLWLHPLIPTDYIKNLPMWRFKCLGVQSEEEMSEGSQDTENDSE 480 490 500 510 520 530 550 560 570 580 590 600 pF1KE3 SENTDTLSSEKEVFEDKQSVLHNSPGTASHCDAEACSCANKYCQTSPCERKGRSYGSYNT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SENTDTLSSEKEVFEDKQSVLHNSPGTASHCDAEACSCANKYCQTSPCERKGRSYGSYNT 540 550 560 570 580 590 610 620 630 640 650 660 pF1KE3 NEDMEPDWLTWPADMLHCTECVVCLENFENGCLLMGLPCGHVFHQNCIVMWLAGGRHCCP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NEDMEPDWLTWPADMLHCTECVVCLENFENGCLLMGLPCGHVFHQNCIVMWLAGGRHCCP 600 610 620 630 640 650 670 680 pF1KE3 VCRWPSYKKKQPYAQHQPLSNDVPS ::::::::::::::::::::::::: NP_001 VCRWPSYKKKQPYAQHQPLSNDVPS 660 670 680 >>NP_001185881 (OMIM: 602507) E3 ubiquitin-protein ligas (122 aa) initn: 789 init1: 789 opt: 789 Z-score: 661.6 bits: 130.4 E(85289): 4.1e-30 Smith-Waterman score: 789; 100.0% identity (100.0% similar) in 122 aa overlap (1-122:1-122) 10 20 30 40 50 60 pF1KE3 MWLKLFFLLLYFLVLFVLARFFEAIVWYETGIFATQLVDPVALSFKKLKTILECRGLGYS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MWLKLFFLLLYFLVLFVLARFFEAIVWYETGIFATQLVDPVALSFKKLKTILECRGLGYS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 GLPEKKDVRELVEKSGDLMEGELYSALKEEEASESVSSTNFSGEMHFYELVEDTKDGIWL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GLPEKKDVRELVEKSGDLMEGELYSALKEEEASESVSSTNFSGEMHFYELVEDTKDGIWL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 VQVIANDRSPLVGKIHWEKMVKKVSRFGIRTGTFNCSSDPRYCRRRGWVRSTLIMSVPQT :: NP_001 VQ >>XP_016879917 (OMIM: 610431) PREDICTED: E3 ubiquitin-pr (227 aa) initn: 195 init1: 170 opt: 187 Z-score: 171.5 bits: 40.6 E(85289): 0.0082 Smith-Waterman score: 187; 39.6% identity (75.0% similar) in 48 aa overlap (621-668:107-154) 600 610 620 630 640 650 pF1KE3 KGRSYGSYNTNEDMEPDWLTWPADMLHCTECVVCLENFENGCLLMGLPCGHVFHQNCIVM :..::...:.: : :::.:..:. :. XP_016 ALNSSMFCPDLILPTCLISSTGFVGDQYDVCAICLDEYEDGDKLRVLPCAHAYHSRCVDP 80 90 100 110 120 130 660 670 680 pF1KE3 WLAGGRHCCPVCRWPSYKKKQPYAQHQPLSNDVPS ::. :. ::.:. : .. XP_016 WLTQTRKTCPICKQPVHRGPGDEDQEEETQGQEEGDEGEPRDHPASERTPLLGSSPTLPT 140 150 160 170 180 190 >>XP_016869786 (OMIM: 612488) PREDICTED: E3 ubiquitin-pr (402 aa) initn: 216 init1: 151 opt: 189 Z-score: 170.3 bits: 41.2 E(85289): 0.0095 Smith-Waterman score: 189; 34.6% identity (54.8% similar) in 104 aa overlap (565-663:291-391) 540 550 560 570 580 590 pF1KE3 TENDSESENTDTLSSEKEVFEDKQSVLHNSPGTASHCDAEACSCANKYCQTSPCERKGRS : . . :.: : . :: :.. XP_016 RSQQPIPPPPYHPSLLPYVLSMLPVPPAVGPTFSFELDVEDGEVENYEALLNLAERLGEA 270 280 290 300 310 320 600 610 620 630 640 pF1KE3 YGSYNTNEDME--PDWLTWPADMLHCTE---CVVCLENFENGCLLMGLPCGHVFHQNCIV :. :.: :.. : . : .: ::::. .::. :: :::.: :: .:. XP_016 KPRGLTKADIEQLPSYRFNPNN--HQSEQTLCVVCMCDFESRQLLRVLPCNHEFHAKCVD 330 340 350 360 370 650 660 670 680 pF1KE3 MWLAGGRHCCPVCRWPSYKKKQPYAQHQPLSNDVPS :: ..: ::.:: XP_016 KWLKANR-TCPICRADASEVHRDSE 380 390 400 >>XP_016869785 (OMIM: 612488) PREDICTED: E3 ubiquitin-pr (402 aa) initn: 216 init1: 151 opt: 189 Z-score: 170.3 bits: 41.2 E(85289): 0.0095 Smith-Waterman score: 189; 34.6% identity (54.8% similar) in 104 aa overlap (565-663:291-391) 540 550 560 570 580 590 pF1KE3 TENDSESENTDTLSSEKEVFEDKQSVLHNSPGTASHCDAEACSCANKYCQTSPCERKGRS : . . :.: : . :: :.. XP_016 RSQQPIPPPPYHPSLLPYVLSMLPVPPAVGPTFSFELDVEDGEVENYEALLNLAERLGEA 270 280 290 300 310 320 600 610 620 630 640 pF1KE3 YGSYNTNEDME--PDWLTWPADMLHCTE---CVVCLENFENGCLLMGLPCGHVFHQNCIV :. :.: :.. : . : .: ::::. .::. :: :::.: :: .:. XP_016 KPRGLTKADIEQLPSYRFNPNN--HQSEQTLCVVCMCDFESRQLLRVLPCNHEFHAKCVD 330 340 350 360 370 650 660 670 680 pF1KE3 MWLAGGRHCCPVCRWPSYKKKQPYAQHQPLSNDVPS :: ..: ::.:: XP_016 KWLKANR-TCPICRADASEVHRDSE 380 390 400 >>XP_006716784 (OMIM: 612488) PREDICTED: E3 ubiquitin-pr (432 aa) initn: 183 init1: 151 opt: 189 Z-score: 169.9 bits: 41.2 E(85289): 0.01 Smith-Waterman score: 189; 34.6% identity (54.8% similar) in 104 aa overlap (565-663:321-421) 540 550 560 570 580 590 pF1KE3 TENDSESENTDTLSSEKEVFEDKQSVLHNSPGTASHCDAEACSCANKYCQTSPCERKGRS : . . :.: : . :: :.. XP_006 RSQQPIPPPPYHPSLLPYVLSMLPVPPAVGPTFSFELDVEDGEVENYEALLNLAERLGEA 300 310 320 330 340 350 600 610 620 630 640 pF1KE3 YGSYNTNEDME--PDWLTWPADMLHCTE---CVVCLENFENGCLLMGLPCGHVFHQNCIV :. :.: :.. : . : .: ::::. .::. :: :::.: :: .:. XP_006 KPRGLTKADIEQLPSYRFNPNN--HQSEQTLCVVCMCDFESRQLLRVLPCNHEFHAKCVD 360 370 380 390 400 650 660 670 680 pF1KE3 MWLAGGRHCCPVCRWPSYKKKQPYAQHQPLSNDVPS :: ..: ::.:: XP_006 KWLKANR-TCPICRADASEVHRDSE 410 420 430 >>NP_919313 (OMIM: 612488) E3 ubiquitin-protein ligase R (432 aa) initn: 183 init1: 151 opt: 189 Z-score: 169.9 bits: 41.2 E(85289): 0.01 Smith-Waterman score: 189; 34.6% identity (54.8% similar) in 104 aa overlap (565-663:321-421) 540 550 560 570 580 590 pF1KE3 TENDSESENTDTLSSEKEVFEDKQSVLHNSPGTASHCDAEACSCANKYCQTSPCERKGRS : . . :.: : . :: :.. NP_919 RSQQPIPPPPYHPSLLPYVLSMLPVPPAVGPTFSFELDVEDGEVENYEALLNLAERLGEA 300 310 320 330 340 350 600 610 620 630 640 pF1KE3 YGSYNTNEDME--PDWLTWPADMLHCTE---CVVCLENFENGCLLMGLPCGHVFHQNCIV :. :.: :.. : . : .: ::::. .::. :: :::.: :: .:. NP_919 KPRGLTKADIEQLPSYRFNPNN--HQSEQTLCVVCMCDFESRQLLRVLPCNHEFHAKCVD 360 370 380 390 400 650 660 670 680 pF1KE3 MWLAGGRHCCPVCRWPSYKKKQPYAQHQPLSNDVPS :: ..: ::.:: NP_919 KWLKANR-TCPICRADASEVHRDSE 410 420 430 >>XP_005251425 (OMIM: 612488) PREDICTED: E3 ubiquitin-pr (432 aa) initn: 183 init1: 151 opt: 189 Z-score: 169.9 bits: 41.2 E(85289): 0.01 Smith-Waterman score: 189; 34.6% identity (54.8% similar) in 104 aa overlap (565-663:321-421) 540 550 560 570 580 590 pF1KE3 TENDSESENTDTLSSEKEVFEDKQSVLHNSPGTASHCDAEACSCANKYCQTSPCERKGRS : . . :.: : . :: :.. XP_005 RSQQPIPPPPYHPSLLPYVLSMLPVPPAVGPTFSFELDVEDGEVENYEALLNLAERLGEA 300 310 320 330 340 350 600 610 620 630 640 pF1KE3 YGSYNTNEDME--PDWLTWPADMLHCTE---CVVCLENFENGCLLMGLPCGHVFHQNCIV :. :.: :.. : . : .: ::::. .::. :: :::.: :: .:. XP_005 KPRGLTKADIEQLPSYRFNPNN--HQSEQTLCVVCMCDFESRQLLRVLPCNHEFHAKCVD 360 370 380 390 400 650 660 670 680 pF1KE3 MWLAGGRHCCPVCRWPSYKKKQPYAQHQPLSNDVPS :: ..: ::.:: XP_005 KWLKANR-TCPICRADASEVHRDSE 410 420 430 >>XP_005251423 (OMIM: 612488) PREDICTED: E3 ubiquitin-pr (432 aa) initn: 183 init1: 151 opt: 189 Z-score: 169.9 bits: 41.2 E(85289): 0.01 Smith-Waterman score: 189; 34.6% identity (54.8% similar) in 104 aa overlap (565-663:321-421) 540 550 560 570 580 590 pF1KE3 TENDSESENTDTLSSEKEVFEDKQSVLHNSPGTASHCDAEACSCANKYCQTSPCERKGRS : . . :.: : . :: :.. XP_005 RSQQPIPPPPYHPSLLPYVLSMLPVPPAVGPTFSFELDVEDGEVENYEALLNLAERLGEA 300 310 320 330 340 350 600 610 620 630 640 pF1KE3 YGSYNTNEDME--PDWLTWPADMLHCTE---CVVCLENFENGCLLMGLPCGHVFHQNCIV :. :.: :.. : . : .: ::::. .::. :: :::.: :: .:. XP_005 KPRGLTKADIEQLPSYRFNPNN--HQSEQTLCVVCMCDFESRQLLRVLPCNHEFHAKCVD 360 370 380 390 400 650 660 670 680 pF1KE3 MWLAGGRHCCPVCRWPSYKKKQPYAQHQPLSNDVPS :: ..: ::.:: XP_005 KWLKANR-TCPICRADASEVHRDSE 410 420 430 685 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 23:32:20 2016 done: Sat Nov 5 23:32:22 2016 Total Scan time: 9.990 Total Display time: 0.060 Function used was FASTA [36.3.4 Apr, 2011]