FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE1890, 418 aa 1>>>pF1KE1890 418 - 418 aa - 418 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.3516+/-0.000356; mu= 12.7710+/- 0.022 mean_var=99.7606+/-19.941, 0's: 0 Z-trim(116.5): 68 B-trim: 0 in 0/54 Lambda= 0.128409 statistics sampled from 27706 (27774) to 27706 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.69), E-opt: 0.2 (0.326), width: 16 Scan time: 8.910 The best scores are: opt bits E(85289) NP_861449 (OMIM: 609292) sprouty-related, EVH1 dom ( 418) 3006 567.3 2.6e-161 NP_001121682 (OMIM: 609292) sprouty-related, EVH1 ( 415) 2950 556.9 3.4e-158 XP_016859065 (OMIM: 609292) PREDICTED: sprouty-rel ( 295) 2149 408.4 1.2e-113 XP_005264258 (OMIM: 609292) PREDICTED: sprouty-rel ( 221) 1661 317.9 1.5e-86 XP_005264257 (OMIM: 609292) PREDICTED: sprouty-rel ( 248) 1338 258.1 1.7e-68 XP_005264259 (OMIM: 609292) PREDICTED: sprouty-rel ( 218) 1336 257.7 2e-68 XP_006723282 (OMIM: 609293) PREDICTED: sprouty-rel ( 410) 990 193.8 6.7e-49 NP_001035987 (OMIM: 609293) sprouty-related, EVH1 ( 410) 990 193.8 6.7e-49 XP_011519591 (OMIM: 609291,611431) PREDICTED: spro ( 423) 937 184.0 6.2e-46 NP_689807 (OMIM: 609291,611431) sprouty-related, E ( 444) 937 184.0 6.5e-46 XP_005254259 (OMIM: 609291,611431) PREDICTED: spro ( 456) 937 184.0 6.6e-46 XP_011525280 (OMIM: 609293) PREDICTED: sprouty-rel ( 379) 753 149.9 1e-35 NP_001291919 (OMIM: 300531) protein sprouty homolo ( 288) 256 57.7 4.3e-08 NP_005831 (OMIM: 300531) protein sprouty homolog 3 ( 288) 256 57.7 4.3e-08 XP_016857242 (OMIM: 609061) PREDICTED: protein ena ( 628) 247 56.3 2.6e-07 XP_016857243 (OMIM: 609061) PREDICTED: protein ena ( 614) 245 55.9 3.3e-07 XP_016857239 (OMIM: 609061) PREDICTED: protein ena ( 839) 245 56.0 4.2e-07 XP_016857236 (OMIM: 609061) PREDICTED: protein ena ( 855) 245 56.0 4.3e-07 XP_016857235 (OMIM: 609061) PREDICTED: protein ena ( 876) 245 56.0 4.4e-07 XP_016857238 (OMIM: 609061) PREDICTED: protein ena ( 851) 243 55.6 5.5e-07 XP_011542531 (OMIM: 609061) PREDICTED: protein ena ( 872) 243 55.6 5.6e-07 XP_005273244 (OMIM: 609061) PREDICTED: protein ena ( 605) 232 53.5 1.7e-06 NP_060682 (OMIM: 609061) protein enabled homolog i ( 570) 230 53.1 2.1e-06 NP_001008493 (OMIM: 609061) protein enabled homolo ( 591) 230 53.1 2.2e-06 NP_001305465 (OMIM: 602466,616818) protein sprouty ( 315) 225 52.0 2.5e-06 NP_001305467 (OMIM: 602466,616818) protein sprouty ( 315) 225 52.0 2.5e-06 NP_005833 (OMIM: 602466,616818) protein sprouty ho ( 315) 225 52.0 2.5e-06 NP_001305466 (OMIM: 602466,616818) protein sprouty ( 315) 225 52.0 2.5e-06 XP_016857241 (OMIM: 609061) PREDICTED: protein ena ( 795) 230 53.2 2.8e-06 XP_016857240 (OMIM: 609061) PREDICTED: protein ena ( 832) 230 53.2 2.9e-06 XP_016857237 (OMIM: 609061) PREDICTED: protein ena ( 853) 230 53.2 2.9e-06 XP_016857244 (OMIM: 609061) PREDICTED: protein ena ( 601) 227 52.5 3.3e-06 NP_005832 (OMIM: 602465) protein sprouty homolog 1 ( 319) 218 50.7 6.2e-06 NP_001244967 (OMIM: 602465) protein sprouty homolo ( 319) 218 50.7 6.2e-06 NP_955359 (OMIM: 602465) protein sprouty homolog 1 ( 319) 218 50.7 6.2e-06 XP_005262743 (OMIM: 602465) PREDICTED: protein spr ( 319) 218 50.7 6.2e-06 NP_001244968 (OMIM: 602465) protein sprouty homolo ( 319) 218 50.7 6.2e-06 XP_016863124 (OMIM: 602465) PREDICTED: protein spr ( 319) 218 50.7 6.2e-06 XP_011535130 (OMIM: 616912) PREDICTED: ena/VASP-li ( 370) 216 50.4 9e-06 NP_001317150 (OMIM: 616912) ena/VASP-like protein ( 416) 216 50.4 9.9e-06 NP_057421 (OMIM: 616912) ena/VASP-like protein iso ( 418) 216 50.4 9.9e-06 XP_005267806 (OMIM: 616912) PREDICTED: ena/VASP-li ( 422) 216 50.4 1e-05 XP_016876852 (OMIM: 616912) PREDICTED: ena/VASP-li ( 429) 216 50.4 1e-05 XP_016882689 (OMIM: 601703) PREDICTED: vasodilator ( 378) 213 49.8 1.3e-05 XP_005259257 (OMIM: 601703) PREDICTED: vasodilator ( 379) 213 49.8 1.3e-05 XP_005259256 (OMIM: 601703) PREDICTED: vasodilator ( 379) 213 49.8 1.3e-05 NP_003361 (OMIM: 601703) vasodilator-stimulated ph ( 380) 213 49.8 1.4e-05 XP_016857246 (OMIM: 609061) PREDICTED: protein ena ( 578) 212 49.8 2.2e-05 XP_016857245 (OMIM: 609061) PREDICTED: protein ena ( 578) 212 49.8 2.2e-05 NP_001280218 (OMIM: 607984,615266) protein sprouty ( 299) 200 47.4 5.9e-05 >>NP_861449 (OMIM: 609292) sprouty-related, EVH1 domain- (418 aa) initn: 3006 init1: 3006 opt: 3006 Z-score: 3017.2 bits: 567.3 E(85289): 2.6e-161 Smith-Waterman score: 3006; 100.0% identity (100.0% similar) in 418 aa overlap (1-418:1-418) 10 20 30 40 50 60 pF1KE1 MTEETHPDDDSYIVRVKAVVMTRDDSSGGWFPQEGGGISRVGVCKVMHPEGNGRSGFLIH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_861 MTEETHPDDDSYIVRVKAVVMTRDDSSGGWFPQEGGGISRVGVCKVMHPEGNGRSGFLIH 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 GERQKDKLVVLECYVRKDLVYTKANPTFHHWKVDNRKFGLTFQSPADARAFDRGVRKAIE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_861 GERQKDKLVVLECYVRKDLVYTKANPTFHHWKVDNRKFGLTFQSPADARAFDRGVRKAIE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 DLIEGSTTSSSTIHNEAELGDDDVFTTATDSSSNSSQKREQPTRTISSPTSCEHRRIYTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_861 DLIEGSTTSSSTIHNEAELGDDDVFTTATDSSSNSSQKREQPTRTISSPTSCEHRRIYTL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 GHLHDSYPTDHYHLDQPMPRPYRQVSFPDDDEEIVRINPREKIWMTGYEDYRHAPVRGKY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_861 GHLHDSYPTDHYHLDQPMPRPYRQVSFPDDDEEIVRINPREKIWMTGYEDYRHAPVRGKY 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 PDPSEDADSSYVRFAKGEVPKHDYNYPYVDSSDFGLGEDPKGRGGSVIKTQPSRGKSRRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_861 PDPSEDADSSYVRFAKGEVPKHDYNYPYVDSSDFGLGEDPKGRGGSVIKTQPSRGKSRRR 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE1 KEDGERSRCVYCRDMFNHEENRRGHCQDAPDSVRTCIRRVSCMWCADSMLYHCMSDPEGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_861 KEDGERSRCVYCRDMFNHEENRRGHCQDAPDSVRTCIRRVSCMWCADSMLYHCMSDPEGD 310 320 330 340 350 360 370 380 390 400 410 pF1KE1 YTDPCSCDTSDEKFCLRWMALIALSFLAPCMCCYLPLRACYHCGVMCRCCGGKHKAAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_861 YTDPCSCDTSDEKFCLRWMALIALSFLAPCMCCYLPLRACYHCGVMCRCCGGKHKAAA 370 380 390 400 410 >>NP_001121682 (OMIM: 609292) sprouty-related, EVH1 doma (415 aa) initn: 2950 init1: 2950 opt: 2950 Z-score: 2961.2 bits: 556.9 E(85289): 3.4e-158 Smith-Waterman score: 2950; 99.5% identity (99.8% similar) in 412 aa overlap (7-418:4-415) 10 20 30 40 50 60 pF1KE1 MTEETHPDDDSYIVRVKAVVMTRDDSSGGWFPQEGGGISRVGVCKVMHPEGNGRSGFLIH : .::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MASPGSDSYIVRVKAVVMTRDDSSGGWFPQEGGGISRVGVCKVMHPEGNGRSGFLIH 10 20 30 40 50 70 80 90 100 110 120 pF1KE1 GERQKDKLVVLECYVRKDLVYTKANPTFHHWKVDNRKFGLTFQSPADARAFDRGVRKAIE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GERQKDKLVVLECYVRKDLVYTKANPTFHHWKVDNRKFGLTFQSPADARAFDRGVRKAIE 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE1 DLIEGSTTSSSTIHNEAELGDDDVFTTATDSSSNSSQKREQPTRTISSPTSCEHRRIYTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DLIEGSTTSSSTIHNEAELGDDDVFTTATDSSSNSSQKREQPTRTISSPTSCEHRRIYTL 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE1 GHLHDSYPTDHYHLDQPMPRPYRQVSFPDDDEEIVRINPREKIWMTGYEDYRHAPVRGKY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GHLHDSYPTDHYHLDQPMPRPYRQVSFPDDDEEIVRINPREKIWMTGYEDYRHAPVRGKY 180 190 200 210 220 230 250 260 270 280 290 300 pF1KE1 PDPSEDADSSYVRFAKGEVPKHDYNYPYVDSSDFGLGEDPKGRGGSVIKTQPSRGKSRRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PDPSEDADSSYVRFAKGEVPKHDYNYPYVDSSDFGLGEDPKGRGGSVIKTQPSRGKSRRR 240 250 260 270 280 290 310 320 330 340 350 360 pF1KE1 KEDGERSRCVYCRDMFNHEENRRGHCQDAPDSVRTCIRRVSCMWCADSMLYHCMSDPEGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KEDGERSRCVYCRDMFNHEENRRGHCQDAPDSVRTCIRRVSCMWCADSMLYHCMSDPEGD 300 310 320 330 340 350 370 380 390 400 410 pF1KE1 YTDPCSCDTSDEKFCLRWMALIALSFLAPCMCCYLPLRACYHCGVMCRCCGGKHKAAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YTDPCSCDTSDEKFCLRWMALIALSFLAPCMCCYLPLRACYHCGVMCRCCGGKHKAAA 360 370 380 390 400 410 >>XP_016859065 (OMIM: 609292) PREDICTED: sprouty-related (295 aa) initn: 2149 init1: 2149 opt: 2149 Z-score: 2161.4 bits: 408.4 E(85289): 1.2e-113 Smith-Waterman score: 2149; 100.0% identity (100.0% similar) in 294 aa overlap (125-418:2-295) 100 110 120 130 140 150 pF1KE1 NRKFGLTFQSPADARAFDRGVRKAIEDLIEGSTTSSSTIHNEAELGDDDVFTTATDSSSN :::::::::::::::::::::::::::::: XP_016 MGSTTSSSTIHNEAELGDDDVFTTATDSSSN 10 20 30 160 170 180 190 200 210 pF1KE1 SSQKREQPTRTISSPTSCEHRRIYTLGHLHDSYPTDHYHLDQPMPRPYRQVSFPDDDEEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SSQKREQPTRTISSPTSCEHRRIYTLGHLHDSYPTDHYHLDQPMPRPYRQVSFPDDDEEI 40 50 60 70 80 90 220 230 240 250 260 270 pF1KE1 VRINPREKIWMTGYEDYRHAPVRGKYPDPSEDADSSYVRFAKGEVPKHDYNYPYVDSSDF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VRINPREKIWMTGYEDYRHAPVRGKYPDPSEDADSSYVRFAKGEVPKHDYNYPYVDSSDF 100 110 120 130 140 150 280 290 300 310 320 330 pF1KE1 GLGEDPKGRGGSVIKTQPSRGKSRRRKEDGERSRCVYCRDMFNHEENRRGHCQDAPDSVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GLGEDPKGRGGSVIKTQPSRGKSRRRKEDGERSRCVYCRDMFNHEENRRGHCQDAPDSVR 160 170 180 190 200 210 340 350 360 370 380 390 pF1KE1 TCIRRVSCMWCADSMLYHCMSDPEGDYTDPCSCDTSDEKFCLRWMALIALSFLAPCMCCY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TCIRRVSCMWCADSMLYHCMSDPEGDYTDPCSCDTSDEKFCLRWMALIALSFLAPCMCCY 220 230 240 250 260 270 400 410 pF1KE1 LPLRACYHCGVMCRCCGGKHKAAA :::::::::::::::::::::::: XP_016 LPLRACYHCGVMCRCCGGKHKAAA 280 290 >>XP_005264258 (OMIM: 609292) PREDICTED: sprouty-related (221 aa) initn: 1661 init1: 1661 opt: 1661 Z-score: 1674.6 bits: 317.9 E(85289): 1.5e-86 Smith-Waterman score: 1661; 100.0% identity (100.0% similar) in 221 aa overlap (198-418:1-221) 170 180 190 200 210 220 pF1KE1 SPTSCEHRRIYTLGHLHDSYPTDHYHLDQPMPRPYRQVSFPDDDEEIVRINPREKIWMTG :::::::::::::::::::::::::::::: XP_005 MPRPYRQVSFPDDDEEIVRINPREKIWMTG 10 20 30 230 240 250 260 270 280 pF1KE1 YEDYRHAPVRGKYPDPSEDADSSYVRFAKGEVPKHDYNYPYVDSSDFGLGEDPKGRGGSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 YEDYRHAPVRGKYPDPSEDADSSYVRFAKGEVPKHDYNYPYVDSSDFGLGEDPKGRGGSV 40 50 60 70 80 90 290 300 310 320 330 340 pF1KE1 IKTQPSRGKSRRRKEDGERSRCVYCRDMFNHEENRRGHCQDAPDSVRTCIRRVSCMWCAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 IKTQPSRGKSRRRKEDGERSRCVYCRDMFNHEENRRGHCQDAPDSVRTCIRRVSCMWCAD 100 110 120 130 140 150 350 360 370 380 390 400 pF1KE1 SMLYHCMSDPEGDYTDPCSCDTSDEKFCLRWMALIALSFLAPCMCCYLPLRACYHCGVMC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SMLYHCMSDPEGDYTDPCSCDTSDEKFCLRWMALIALSFLAPCMCCYLPLRACYHCGVMC 160 170 180 190 200 210 410 pF1KE1 RCCGGKHKAAA ::::::::::: XP_005 RCCGGKHKAAA 220 >>XP_005264257 (OMIM: 609292) PREDICTED: sprouty-related (248 aa) initn: 1337 init1: 1337 opt: 1338 Z-score: 1350.5 bits: 258.1 E(85289): 1.7e-68 Smith-Waterman score: 1338; 92.6% identity (94.4% similar) in 216 aa overlap (1-213:1-216) 10 20 30 40 50 60 pF1KE1 MTEETHPDDDSYIVRVKAVVMTRDDSSGGWFPQEGGGISRVGVCKVMHPEGNGRSGFLIH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MTEETHPDDDSYIVRVKAVVMTRDDSSGGWFPQEGGGISRVGVCKVMHPEGNGRSGFLIH 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 GERQKDKLVVLECYVRKDLVYTKANPTFHHWKVDNRKFGLTFQSPADARAFDRGVRKAIE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GERQKDKLVVLECYVRKDLVYTKANPTFHHWKVDNRKFGLTFQSPADARAFDRGVRKAIE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 DLIEGSTTSSSTIHNEAELGDDDVFTTATDSSSNSSQKREQPTRTISSPTSCEHRRIYTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DLIEGSTTSSSTIHNEAELGDDDVFTTATDSSSNSSQKREQPTRTISSPTSCEHRRIYTL 130 140 150 160 170 180 190 200 210 220 230 pF1KE1 GHLHDSYPTDHYHLDQPMPRPY---RQVSFPDDDEEIVRINPREKIWMTGYEDYRHAPVR :::::::::::::::: . . : .:: . : XP_005 GHLHDSYPTDHYHLDQALRKHQELERTTSFKAQKAEAHYQYFVCSQLQGRLQKCTKLAGF 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE1 GKYPDPSEDADSSYVRFAKGEVPKHDYNYPYVDSSDFGLGEDPKGRGGSVIKTQPSRGKS XP_005 LGANASNW >>XP_005264259 (OMIM: 609292) PREDICTED: sprouty-related (218 aa) initn: 1335 init1: 1335 opt: 1336 Z-score: 1349.3 bits: 257.7 E(85289): 2e-68 Smith-Waterman score: 1336; 98.5% identity (99.0% similar) in 200 aa overlap (1-200:1-200) 10 20 30 40 50 60 pF1KE1 MTEETHPDDDSYIVRVKAVVMTRDDSSGGWFPQEGGGISRVGVCKVMHPEGNGRSGFLIH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MTEETHPDDDSYIVRVKAVVMTRDDSSGGWFPQEGGGISRVGVCKVMHPEGNGRSGFLIH 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 GERQKDKLVVLECYVRKDLVYTKANPTFHHWKVDNRKFGLTFQSPADARAFDRGVRKAIE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GERQKDKLVVLECYVRKDLVYTKANPTFHHWKVDNRKFGLTFQSPADARAFDRGVRKAIE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 DLIEGSTTSSSTIHNEAELGDDDVFTTATDSSSNSSQKREQPTRTISSPTSCEHRRIYTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DLIEGSTTSSSTIHNEAELGDDDVFTTATDSSSNSSQKREQPTRTISSPTSCEHRRIYTL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 GHLHDSYPTDHYHLDQPMPRPYRQVSFPDDDEEIVRINPREKIWMTGYEDYRHAPVRGKY :::::::::::::::: . : XP_005 GHLHDSYPTDHYHLDQLQGRLQKCTKLAGFLGANASNW 190 200 210 >>XP_006723282 (OMIM: 609293) PREDICTED: sprouty-related (410 aa) initn: 909 init1: 368 opt: 990 Z-score: 998.9 bits: 193.8 E(85289): 6.7e-49 Smith-Waterman score: 990; 39.4% identity (63.2% similar) in 419 aa overlap (13-418:1-409) 10 20 30 40 50 pF1KE1 MTEETHPDDDSYIVRVKAVVMTRDDSSGGWFPQEGGGISRVGVCKV--MHPEGNGRSG-F .:::.::::.::::::::.: :::.:.:.::.: .:::..:.: . XP_006 MVRVRAVVMARDDSSGGWLPVGGGGLSQVSVCRVRGARPEGGARQGHY 10 20 30 40 60 70 80 90 100 110 pF1KE1 LIHGERQKDKLVVLECYVRKDLVYTKANPTFHHWKVDNRKFGLTFQSPADARAFDRGVRK .::::: .:. ..::: .. :::.:.:: ::::.. . ::::::::::.: :.... XP_006 VIHGERLRDQKTTLECTLKPGLVYNKVNPIFHHWSLGDCKFGLTFQSPAEADEFQKSLLA 50 60 70 80 90 100 120 130 140 150 160 170 pF1KE1 AIEDLIEGSTTSSSTIHNEAELGDDDV----FTTATDSSSNSSQKR-EQPTRTISSPTSC :. : .:: : ::. . . : .:. .::.:.::..: : : . ..: XP_006 ALAALGRGSLTPSSSSSSSSPSQDTAETPCPLTSHVDSDSSSSHSRQETPPSAAAAPIIT 110 120 130 140 150 160 180 190 200 210 220 230 pF1KE1 EHRRIYTLGHLHDSYPTDHYHLDQPMPRPYRQVSFPDDDEEIVRINPREKIWM-TGYEDY . . : . : . : .: ...:. .: .. . : ::::: XP_006 MES---ASGFGPTTPPQRRRSSAQSYPPLLPFTGIPEPSEPLAGAGGLG--WGGRGYEDY 170 180 190 200 210 220 240 250 260 270 280 290 pF1KE1 RHAPVRGKYPDPSEDADSSYVRFAK-GEVPKHDYNYPYVDSSDFGLGEDPKGRGGSVIKT : :. : : .. ::::: : . . : . . . . : . XP_006 R----RSGPPAPLA-LSTCVVRFAKTGALRGAALGPPAALPAPLTEAAPPAPPARPPPGP 230 240 250 260 270 300 310 320 330 340 pF1KE1 QPSRGKSRRRKEDGERSRCVYCRDMFNHE-ENRRGHCQDAPDSVRTCIRRVSCMWCADSM :: . .. : : .:::.:: .: .. ..: :.: .::: : .::.::.:::.:. XP_006 GPSSAPAKASPEAEEAARCVHCRALFRRRADGRGGRCAEAPDPGRLLVRRLSCLWCAESL 280 290 300 310 320 330 350 360 370 380 390 400 pF1KE1 LYHCMSDPEGDYTDPCSCDTSDEKFCLRWMALIALSFLAPCMCCYLPLRACYHCGVMCRC ::::.:: :::..:::.:. . . :: :: :::. .::.::: :::::. .. : : XP_006 LYHCLSDAEGDFSDPCACEPGHPRPAARWAALAALSLAVPCLCCYAPLRACHWVAARCGC 340 350 360 370 380 390 410 pF1KE1 --CGGKHKAAA :::.:. :: XP_006 AGCGGRHEEAAR 400 410 >>NP_001035987 (OMIM: 609293) sprouty-related, EVH1 doma (410 aa) initn: 909 init1: 368 opt: 990 Z-score: 998.9 bits: 193.8 E(85289): 6.7e-49 Smith-Waterman score: 990; 39.4% identity (63.2% similar) in 419 aa overlap (13-418:1-409) 10 20 30 40 50 pF1KE1 MTEETHPDDDSYIVRVKAVVMTRDDSSGGWFPQEGGGISRVGVCKV--MHPEGNGRSG-F .:::.::::.::::::::.: :::.:.:.::.: .:::..:.: . NP_001 MVRVRAVVMARDDSSGGWLPVGGGGLSQVSVCRVRGARPEGGARQGHY 10 20 30 40 60 70 80 90 100 110 pF1KE1 LIHGERQKDKLVVLECYVRKDLVYTKANPTFHHWKVDNRKFGLTFQSPADARAFDRGVRK .::::: .:. ..::: .. :::.:.:: ::::.. . ::::::::::.: :.... NP_001 VIHGERLRDQKTTLECTLKPGLVYNKVNPIFHHWSLGDCKFGLTFQSPAEADEFQKSLLA 50 60 70 80 90 100 120 130 140 150 160 170 pF1KE1 AIEDLIEGSTTSSSTIHNEAELGDDDV----FTTATDSSSNSSQKR-EQPTRTISSPTSC :. : .:: : ::. . . : .:. .::.:.::..: : : . ..: NP_001 ALAALGRGSLTPSSSSSSSSPSQDTAETPCPLTSHVDSDSSSSHSRQETPPSAAAAPIIT 110 120 130 140 150 160 180 190 200 210 220 230 pF1KE1 EHRRIYTLGHLHDSYPTDHYHLDQPMPRPYRQVSFPDDDEEIVRINPREKIWM-TGYEDY . . : . : . : .: ...:. .: .. . : ::::: NP_001 MES---ASGFGPTTPPQRRRSSAQSYPPLLPFTGIPEPSEPLAGAGGLG--WGGRGYEDY 170 180 190 200 210 220 240 250 260 270 280 290 pF1KE1 RHAPVRGKYPDPSEDADSSYVRFAK-GEVPKHDYNYPYVDSSDFGLGEDPKGRGGSVIKT : :. : : .. ::::: : . . : . . . . : . NP_001 R----RSGPPAPLA-LSTCVVRFAKTGALRGAALGPPAALPAPLTEAAPPAPPARPPPGP 230 240 250 260 270 300 310 320 330 340 pF1KE1 QPSRGKSRRRKEDGERSRCVYCRDMFNHE-ENRRGHCQDAPDSVRTCIRRVSCMWCADSM :: . .. : : .:::.:: .: .. ..: :.: .::: : .::.::.:::.:. NP_001 GPSSAPAKASPEAEEAARCVHCRALFRRRADGRGGRCAEAPDPGRLLVRRLSCLWCAESL 280 290 300 310 320 330 350 360 370 380 390 400 pF1KE1 LYHCMSDPEGDYTDPCSCDTSDEKFCLRWMALIALSFLAPCMCCYLPLRACYHCGVMCRC ::::.:: :::..:::.:. . . :: :: :::. .::.::: :::::. .. : : NP_001 LYHCLSDAEGDFSDPCACEPGHPRPAARWAALAALSLAVPCLCCYAPLRACHWVAARCGC 340 350 360 370 380 390 410 pF1KE1 --CGGKHKAAA :::.:. :: NP_001 AGCGGRHEEAAR 400 410 >>XP_011519591 (OMIM: 609291,611431) PREDICTED: sprouty- (423 aa) initn: 1320 init1: 769 opt: 937 Z-score: 945.6 bits: 184.0 E(85289): 6.2e-46 Smith-Waterman score: 1427; 53.1% identity (70.3% similar) in 437 aa overlap (21-417:1-422) 10 20 30 40 50 60 pF1KE1 MTEETHPDDDSYIVRVKAVVMTRDDSSGGWFPQEGGGISRVGVCKVMHPEGNGRSGFLIH ::::::::::.: :.:.: : : :: : : :: . :.:. XP_011 MTRDDSSGGWLPLGGSGLSSVTVFKVPHQEENGCADFFIR 10 20 30 40 70 80 90 100 110 120 pF1KE1 GERQKDKLVVLECYVRKDLVYTKANPTFHHWKVDNRKFGLTFQSPADARAFDRGVRKAIE ::: .::.:::::...:::.:.:..:::::::.:..::::::::::::::::::.:.::: XP_011 GERLRDKMVVLECMLKKDLIYNKVTPTFHHWKIDDKKFGLTFQSPADARAFDRGIRRAIE 50 60 70 80 90 100 130 140 150 160 170 pF1KE1 DLIEGSTTSSSTIHNEAELGDDDVFTTATDSSSNSSQ----KRE-----QPTRTIS-SPT :. .: :. :::: : ::. .. ::::. . ..: .: :. . :. XP_011 DISQGCPESK----NEAE-GADDLQANEEDSSSSLVKDHLFQQETVVTSEPYRSSNIRPS 110 120 130 140 150 180 190 200 pF1KE1 SCEH---RRIY--------TLGH--LHDSYPTDHYHLDQ--------------PMPRPYR : ::.: :.:. : . . .: : :. . : XP_011 PFEDLNARRVYMQSQANQITFGQPGLDIQSRSMEYVQRQISKECGSLKSQNRVPL-KSIR 160 170 180 190 200 210 210 220 230 240 250 260 pF1KE1 QVSFPDDDEEIVRINPREKIWMTGYEDYRHAPVRGKYPDPSEDADSSYVRFAKGEVPKHD .::: :.:: :::::::. : . : :::: : : .::::: ..:.: . : : XP_011 HVSFQDEDE-IVRINPRD-ILIRRYADYRH-PDMWKNDLERDDADSS-IQFSKPDSKKSD 220 230 240 250 260 270 270 280 290 300 310 320 pF1KE1 YNYPYVDSSDFGLGEDPKGRGGSVIKTQPSR---GKSRRRKEDGERSRCVYCRDMFNHEE : : : . .. .:: . :.::::: ::.::::::::::::::.. ::::: XP_011 YLYSCGDETKLS---SPKD--SVVFKTQPSSLKIKKSKRRKEDGERSRCVYCQERFNHEE 280 290 300 310 320 330 340 350 360 370 380 pF1KE1 NRRGHCQDAPDSVRTCIRRVSCMWCADSMLYHCMSDPEGDYTDPCSCDTSDEKFCLRWMA : ::.:::::: .. :: .:::: ::.::::::::: :::..:::::::::.::::::.: XP_011 NVRGKCQDAPDPIKRCIYQVSCMLCAESMLYHCMSDSEGDFSDPCSCDTSDDKFCLRWLA 330 340 350 360 370 380 390 400 410 pF1KE1 LIALSFLAPCMCCYLPLRACYHCGVMCRCCGGKHKAAA :.::::..::::::.::: :..:: : ::::::::: XP_011 LVALSFIVPCMCCYVPLRMCHRCGEACGCCGGKHKAAG 390 400 410 420 >>NP_689807 (OMIM: 609291,611431) sprouty-related, EVH1 (444 aa) initn: 1368 init1: 769 opt: 937 Z-score: 945.3 bits: 184.0 E(85289): 6.5e-46 Smith-Waterman score: 1484; 53.1% identity (70.5% similar) in 458 aa overlap (1-417:1-443) 10 20 30 40 50 pF1KE1 MTEETHP-DDDSYIVRVKAVVMTRDDSSGGWFPQEGGGISRVGVCKVMHPEGNGRSGFLI :.::: :.:. .::.:::::::::::::.: :.:.: : : :: : : :: . :.: NP_689 MSEETATSDNDNSYARVRAVVMTRDDSSGGWLPLGGSGLSSVTVFKVPHQEENGCADFFI 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE1 HGERQKDKLVVLECYVRKDLVYTKANPTFHHWKVDNRKFGLTFQSPADARAFDRGVRKAI .::: .::.:::::...:::.:.:..:::::::.:..::::::::::::::::::.:.:: NP_689 RGERLRDKMVVLECMLKKDLIYNKVTPTFHHWKIDDKKFGLTFQSPADARAFDRGIRRAI 70 80 90 100 110 120 120 130 140 150 160 pF1KE1 EDLIEGSTTSSSTIHNEAELGDDDVFTTATDSSSNSSQ----KRE-----QPTRTIS-SP ::. .: :. :::: : ::. .. ::::. . ..: .: :. . : NP_689 EDISQGCPESK----NEAE-GADDLQANEEDSSSSLVKDHLFQQETVVTSEPYRSSNIRP 130 140 150 160 170 170 180 190 200 pF1KE1 TSCEH---RRIY--------TLGH--LHDSYPTDHYHLDQ--------------PMPRPY . : ::.: :.:. : . . .: : :. . NP_689 SPFEDLNARRVYMQSQANQITFGQPGLDIQSRSMEYVQRQISKECGSLKSQNRVPL-KSI 180 190 200 210 220 230 210 220 230 240 250 260 pF1KE1 RQVSFPDDDEEIVRINPREKIWMTGYEDYRHAPVRGKYPDPSEDADSSYVRFAKGEVPKH :.::: :.:: :::::::. : . : :::: : : .::::: ..:.: . : NP_689 RHVSFQDEDE-IVRINPRD-ILIRRYADYRH-PDMWKNDLERDDADSS-IQFSKPDSKKS 240 250 260 270 280 290 270 280 290 300 310 pF1KE1 DYNYPYVDSSDFGLGEDPKGRGGSVIKTQPSR---GKSRRRKEDGERSRCVYCRDMFNHE :: : : . .. .:: . :.::::: ::.::::::::::::::.. :::: NP_689 DYLYSCGDETKLS---SPKD--SVVFKTQPSSLKIKKSKRRKEDGERSRCVYCQERFNHE 300 310 320 330 340 320 330 340 350 360 370 pF1KE1 ENRRGHCQDAPDSVRTCIRRVSCMWCADSMLYHCMSDPEGDYTDPCSCDTSDEKFCLRWM :: ::.:::::: .. :: .:::: ::.::::::::: :::..:::::::::.::::::. NP_689 ENVRGKCQDAPDPIKRCIYQVSCMLCAESMLYHCMSDSEGDFSDPCSCDTSDDKFCLRWL 350 360 370 380 390 400 380 390 400 410 pF1KE1 ALIALSFLAPCMCCYLPLRACYHCGVMCRCCGGKHKAAA ::.::::..::::::.::: :..:: : ::::::::: NP_689 ALVALSFIVPCMCCYVPLRMCHRCGEACGCCGGKHKAAG 410 420 430 440 418 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 12:07:47 2016 done: Sun Nov 6 12:07:49 2016 Total Scan time: 8.910 Total Display time: 0.040 Function used was FASTA [36.3.4 Apr, 2011]