Result of FASTA (omim) for
pFN21AB9439
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB9439, 463 aa
1>>>pF1KB9439 463 - 463 aa - 463 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 9.7030+/-0.000348; mu= 1.8260+/- 0.022
mean_var=325.3154+/-65.521, 0's: 0 Z-trim(125.1): 57 B-trim: 591 in 1/57
Lambda= 0.071109
statistics sampled from 47900 (47971) to 47900 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.822), E-opt: 0.2 (0.562), width: 16
Scan time: 11.510
The best scores are: opt bits E(85289)
NP_002689 (OMIM: 164176) POU domain, class 2, tran ( 463) 3152 336.4 9.7e-92
XP_005259067 (OMIM: 164176) PREDICTED: POU domain, ( 586) 3042 325.3 2.8e-88
XP_011525344 (OMIM: 164176) PREDICTED: POU domain, ( 485) 2748 295.0 3e-79
XP_016882382 (OMIM: 164176) PREDICTED: POU domain, ( 608) 2638 283.8 8.7e-76
NP_001234923 (OMIM: 164176) POU domain, class 2, t ( 400) 2590 278.7 2e-74
XP_016882380 (OMIM: 164176) PREDICTED: POU domain, ( 707) 2414 260.9 8e-69
NP_001193954 (OMIM: 164176) POU domain, class 2, t ( 479) 2113 229.9 1.2e-59
XP_016882385 (OMIM: 164176) PREDICTED: POU domain, ( 600) 2111 229.8 1.6e-59
XP_011525343 (OMIM: 164176) PREDICTED: POU domain, ( 501) 2104 229.0 2.4e-59
NP_001193955 (OMIM: 164176) POU domain, class 2, t ( 467) 2003 218.6 3e-56
XP_016882384 (OMIM: 164176) PREDICTED: POU domain, ( 602) 2003 218.7 3.5e-56
XP_016882383 (OMIM: 164176) PREDICTED: POU domain, ( 602) 2003 218.7 3.5e-56
XP_016882381 (OMIM: 164176) PREDICTED: POU domain, ( 701) 2001 218.5 4.5e-56
XP_016882375 (OMIM: 164176) PREDICTED: POU domain, ( 711) 2001 218.5 4.6e-56
XP_016882377 (OMIM: 164176) PREDICTED: POU domain, ( 711) 2001 218.5 4.6e-56
XP_016882379 (OMIM: 164176) PREDICTED: POU domain, ( 711) 2001 218.5 4.6e-56
XP_016882378 (OMIM: 164176) PREDICTED: POU domain, ( 711) 2001 218.5 4.6e-56
XP_016882376 (OMIM: 164176) PREDICTED: POU domain, ( 711) 2001 218.5 4.6e-56
XP_016882374 (OMIM: 164176) PREDICTED: POU domain, ( 723) 2001 218.6 4.6e-56
XP_016882373 (OMIM: 164176) PREDICTED: POU domain, ( 723) 2001 218.6 4.6e-56
XP_011525342 (OMIM: 164176) PREDICTED: POU domain, ( 624) 1994 217.8 6.9e-56
XP_011525345 (OMIM: 164176) PREDICTED: POU domain, ( 537) 1549 172.1 3.4e-42
NP_001185715 (OMIM: 164175) POU domain, class 2, t ( 703) 1089 125.0 6.6e-28
XP_011507957 (OMIM: 164175) PREDICTED: POU domain, ( 671) 1079 123.9 1.3e-27
XP_011507956 (OMIM: 164175) PREDICTED: POU domain, ( 743) 1079 124.0 1.4e-27
NP_001185712 (OMIM: 164175) POU domain, class 2, t ( 755) 1079 124.0 1.4e-27
NP_002688 (OMIM: 164175) POU domain, class 2, tran ( 766) 1079 124.0 1.4e-27
XP_011507955 (OMIM: 164175) PREDICTED: POU domain, ( 769) 1079 124.0 1.4e-27
NP_001231611 (OMIM: 607394) POU domain, class 2, t ( 438) 939 109.4 2e-23
XP_011541041 (OMIM: 607394) PREDICTED: POU domain, ( 432) 937 109.2 2.3e-23
XP_011541042 (OMIM: 607394) PREDICTED: POU domain, ( 432) 937 109.2 2.3e-23
NP_055167 (OMIM: 607394) POU domain, class 2, tran ( 436) 934 108.9 2.9e-23
XP_016872976 (OMIM: 607394) PREDICTED: POU domain, ( 356) 920 107.3 6.8e-23
XP_011541045 (OMIM: 607394) PREDICTED: POU domain, ( 403) 921 107.5 6.9e-23
XP_011541044 (OMIM: 607394) PREDICTED: POU domain, ( 403) 921 107.5 6.9e-23
XP_011541043 (OMIM: 607394) PREDICTED: POU domain, ( 403) 921 107.5 6.9e-23
XP_016856997 (OMIM: 164175) PREDICTED: POU domain, ( 381) 556 70.0 1.3e-11
NP_001159490 (OMIM: 601583,609062) POU domain, cla ( 655) 462 60.6 1.5e-08
NP_005595 (OMIM: 600494) POU domain, class 3, tran ( 443) 417 55.8 2.7e-07
NP_000298 (OMIM: 300039,304400) POU domain, class ( 361) 412 55.2 3.4e-07
NP_006227 (OMIM: 602480) POU domain, class 3, tran ( 500) 403 54.5 8e-07
NP_002690 (OMIM: 602479) POU domain, class 3, tran ( 451) 387 52.8 2.3e-06
NP_002692 (OMIM: 164177) POU domain, class 5, tran ( 360) 350 48.9 2.8e-05
NP_001153014 (OMIM: 615739) putative POU domain, c ( 359) 344 48.3 4.2e-05
NP_001272916 (OMIM: 164177) POU domain, class 5, t ( 265) 336 47.3 6.1e-05
NP_002691 (OMIM: 602459,602460) POU domain, class ( 338) 325 46.3 0.00016
NP_004566 (OMIM: 113725) POU domain, class 4, tran ( 409) 326 46.5 0.00017
NP_006228 (OMIM: 601632) POU domain, class 4, tran ( 419) 322 46.1 0.00022
NP_000297 (OMIM: 173110,613038) pituitary-specific ( 291) 311 44.8 0.00038
NP_001116229 (OMIM: 173110,613038) pituitary-speci ( 317) 311 44.8 0.00041
>>NP_002689 (OMIM: 164176) POU domain, class 2, transcri (463 aa)
initn: 3152 init1: 3152 opt: 3152 Z-score: 1768.0 bits: 336.4 E(85289): 9.7e-92
Smith-Waterman score: 3152; 100.0% identity (100.0% similar) in 463 aa overlap (1-463:1-463)
10 20 30 40 50 60
pF1KB9 MVHSSMGAPEIRMSKPLEAEKQGLDSPSEHTDTERNGPDTNHQNPQNKTSPFSVSPTGPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MVHSSMGAPEIRMSKPLEAEKQGLDSPSEHTDTERNGPDTNHQNPQNKTSPFSVSPTGPS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB9 TKIKAEDPSGDSAPAAPLPPQPAQPHLPQAQLMLTGSQLAGDIQQLLQLQQLVLVPGHHL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 TKIKAEDPSGDSAPAAPLPPQPAQPHLPQAQLMLTGSQLAGDIQQLLQLQQLVLVPGHHL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB9 QPPAQFLLPQAQQSQPGLLPTPNLFQLPQQTQGALLTSQPRAGLPTQPPKCLEPPSHPEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 QPPAQFLLPQAQQSQPGLLPTPNLFQLPQQTQGALLTSQPRAGLPTQPPKCLEPPSHPEE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB9 PSDLEELEQFARTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMCK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 PSDLEELEQFARTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMCK
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB9 LKPLLEKWLNDAETMSVDSSLPSPNQLSSPSLGFDGLPGRRRKKRTSIETNVRFALEKSF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 LKPLLEKWLNDAETMSVDSSLPSPNQLSSPSLGFDGLPGRRRKKRTSIETNVRFALEKSF
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB9 LANQKPTSEEILLIAEQLHMEKEVIRVWFCNRRQKEKRINPCSAAPMLPSPGKPASYSPH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 LANQKPTSEEILLIAEQLHMEKEVIRVWFCNRRQKEKRINPCSAAPMLPSPGKPASYSPH
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB9 MVTPQGGAGTLPLSQASSSLSTTVTTLSSAVGTLHPSRTAGGGGGGGGAAPPLNSIPSVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MVTPQGGAGTLPLSQASSSLSTTVTTLSSAVGTLHPSRTAGGGGGGGGAAPPLNSIPSVT
370 380 390 400 410 420
430 440 450 460
pF1KB9 PPPPATTNSTNPSPQGSHSAIGLSGLNPSTGPGLWWNPAPYQP
:::::::::::::::::::::::::::::::::::::::::::
NP_002 PPPPATTNSTNPSPQGSHSAIGLSGLNPSTGPGLWWNPAPYQP
430 440 450 460
>>XP_005259067 (OMIM: 164176) PREDICTED: POU domain, cla (586 aa)
initn: 3042 init1: 3042 opt: 3042 Z-score: 1705.8 bits: 325.3 E(85289): 2.8e-88
Smith-Waterman score: 3042; 100.0% identity (100.0% similar) in 451 aa overlap (1-451:1-451)
10 20 30 40 50 60
pF1KB9 MVHSSMGAPEIRMSKPLEAEKQGLDSPSEHTDTERNGPDTNHQNPQNKTSPFSVSPTGPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MVHSSMGAPEIRMSKPLEAEKQGLDSPSEHTDTERNGPDTNHQNPQNKTSPFSVSPTGPS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB9 TKIKAEDPSGDSAPAAPLPPQPAQPHLPQAQLMLTGSQLAGDIQQLLQLQQLVLVPGHHL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TKIKAEDPSGDSAPAAPLPPQPAQPHLPQAQLMLTGSQLAGDIQQLLQLQQLVLVPGHHL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB9 QPPAQFLLPQAQQSQPGLLPTPNLFQLPQQTQGALLTSQPRAGLPTQPPKCLEPPSHPEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QPPAQFLLPQAQQSQPGLLPTPNLFQLPQQTQGALLTSQPRAGLPTQPPKCLEPPSHPEE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB9 PSDLEELEQFARTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMCK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PSDLEELEQFARTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMCK
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB9 LKPLLEKWLNDAETMSVDSSLPSPNQLSSPSLGFDGLPGRRRKKRTSIETNVRFALEKSF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LKPLLEKWLNDAETMSVDSSLPSPNQLSSPSLGFDGLPGRRRKKRTSIETNVRFALEKSF
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB9 LANQKPTSEEILLIAEQLHMEKEVIRVWFCNRRQKEKRINPCSAAPMLPSPGKPASYSPH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LANQKPTSEEILLIAEQLHMEKEVIRVWFCNRRQKEKRINPCSAAPMLPSPGKPASYSPH
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB9 MVTPQGGAGTLPLSQASSSLSTTVTTLSSAVGTLHPSRTAGGGGGGGGAAPPLNSIPSVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MVTPQGGAGTLPLSQASSSLSTTVTTLSSAVGTLHPSRTAGGGGGGGGAAPPLNSIPSVT
370 380 390 400 410 420
430 440 450 460
pF1KB9 PPPPATTNSTNPSPQGSHSAIGLSGLNPSTGPGLWWNPAPYQP
:::::::::::::::::::::::::::::::
XP_005 PPPPATTNSTNPSPQGSHSAIGLSGLNPSTGSTMVGLSSGLSPALMSNNPLATIQALASG
430 440 450 460 470 480
XP_005 GTLPLTSLDGSGNLVLGAAGAAPGSPGLVTSPLFLNHAGLPLLSTPPGVGLVSAAAAAVA
490 500 510 520 530 540
>>XP_011525344 (OMIM: 164176) PREDICTED: POU domain, cla (485 aa)
initn: 2732 init1: 2732 opt: 2748 Z-score: 1543.8 bits: 295.0 E(85289): 3e-79
Smith-Waterman score: 3098; 95.5% identity (95.5% similar) in 485 aa overlap (1-463:1-485)
10 20 30 40 50 60
pF1KB9 MVHSSMGAPEIRMSKPLEAEKQGLDSPSEHTDTERNGPDTNHQNPQNKTSPFSVSPTGPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MVHSSMGAPEIRMSKPLEAEKQGLDSPSEHTDTERNGPDTNHQNPQNKTSPFSVSPTGPS
10 20 30 40 50 60
70 80 90
pF1KB9 TK----------------------IKAEDPSGDSAPAAPLPPQPAQPHLPQAQLMLTGSQ
:: ::::::::::::::::::::::::::::::::::::
XP_011 TKVGILSGLHLTFWGPGPCLSPPQIKAEDPSGDSAPAAPLPPQPAQPHLPQAQLMLTGSQ
70 80 90 100 110 120
100 110 120 130 140 150
pF1KB9 LAGDIQQLLQLQQLVLVPGHHLQPPAQFLLPQAQQSQPGLLPTPNLFQLPQQTQGALLTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LAGDIQQLLQLQQLVLVPGHHLQPPAQFLLPQAQQSQPGLLPTPNLFQLPQQTQGALLTS
130 140 150 160 170 180
160 170 180 190 200 210
pF1KB9 QPRAGLPTQPPKCLEPPSHPEEPSDLEELEQFARTFKQRRIKLGFTQGDVGLAMGKLYGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QPRAGLPTQPPKCLEPPSHPEEPSDLEELEQFARTFKQRRIKLGFTQGDVGLAMGKLYGN
190 200 210 220 230 240
220 230 240 250 260 270
pF1KB9 DFSQTTISRFEALNLSFKNMCKLKPLLEKWLNDAETMSVDSSLPSPNQLSSPSLGFDGLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DFSQTTISRFEALNLSFKNMCKLKPLLEKWLNDAETMSVDSSLPSPNQLSSPSLGFDGLP
250 260 270 280 290 300
280 290 300 310 320 330
pF1KB9 GRRRKKRTSIETNVRFALEKSFLANQKPTSEEILLIAEQLHMEKEVIRVWFCNRRQKEKR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GRRRKKRTSIETNVRFALEKSFLANQKPTSEEILLIAEQLHMEKEVIRVWFCNRRQKEKR
310 320 330 340 350 360
340 350 360 370 380 390
pF1KB9 INPCSAAPMLPSPGKPASYSPHMVTPQGGAGTLPLSQASSSLSTTVTTLSSAVGTLHPSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 INPCSAAPMLPSPGKPASYSPHMVTPQGGAGTLPLSQASSSLSTTVTTLSSAVGTLHPSR
370 380 390 400 410 420
400 410 420 430 440 450
pF1KB9 TAGGGGGGGGAAPPLNSIPSVTPPPPATTNSTNPSPQGSHSAIGLSGLNPSTGPGLWWNP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TAGGGGGGGGAAPPLNSIPSVTPPPPATTNSTNPSPQGSHSAIGLSGLNPSTGPGLWWNP
430 440 450 460 470 480
460
pF1KB9 APYQP
:::::
XP_011 APYQP
>>XP_016882382 (OMIM: 164176) PREDICTED: POU domain, cla (608 aa)
initn: 2622 init1: 2622 opt: 2638 Z-score: 1481.6 bits: 283.8 E(85289): 8.7e-76
Smith-Waterman score: 2988; 95.3% identity (95.3% similar) in 473 aa overlap (1-451:1-473)
10 20 30 40 50 60
pF1KB9 MVHSSMGAPEIRMSKPLEAEKQGLDSPSEHTDTERNGPDTNHQNPQNKTSPFSVSPTGPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MVHSSMGAPEIRMSKPLEAEKQGLDSPSEHTDTERNGPDTNHQNPQNKTSPFSVSPTGPS
10 20 30 40 50 60
70 80 90
pF1KB9 TK----------------------IKAEDPSGDSAPAAPLPPQPAQPHLPQAQLMLTGSQ
:: ::::::::::::::::::::::::::::::::::::
XP_016 TKVGILSGLHLTFWGPGPCLSPPQIKAEDPSGDSAPAAPLPPQPAQPHLPQAQLMLTGSQ
70 80 90 100 110 120
100 110 120 130 140 150
pF1KB9 LAGDIQQLLQLQQLVLVPGHHLQPPAQFLLPQAQQSQPGLLPTPNLFQLPQQTQGALLTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LAGDIQQLLQLQQLVLVPGHHLQPPAQFLLPQAQQSQPGLLPTPNLFQLPQQTQGALLTS
130 140 150 160 170 180
160 170 180 190 200 210
pF1KB9 QPRAGLPTQPPKCLEPPSHPEEPSDLEELEQFARTFKQRRIKLGFTQGDVGLAMGKLYGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QPRAGLPTQPPKCLEPPSHPEEPSDLEELEQFARTFKQRRIKLGFTQGDVGLAMGKLYGN
190 200 210 220 230 240
220 230 240 250 260 270
pF1KB9 DFSQTTISRFEALNLSFKNMCKLKPLLEKWLNDAETMSVDSSLPSPNQLSSPSLGFDGLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DFSQTTISRFEALNLSFKNMCKLKPLLEKWLNDAETMSVDSSLPSPNQLSSPSLGFDGLP
250 260 270 280 290 300
280 290 300 310 320 330
pF1KB9 GRRRKKRTSIETNVRFALEKSFLANQKPTSEEILLIAEQLHMEKEVIRVWFCNRRQKEKR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GRRRKKRTSIETNVRFALEKSFLANQKPTSEEILLIAEQLHMEKEVIRVWFCNRRQKEKR
310 320 330 340 350 360
340 350 360 370 380 390
pF1KB9 INPCSAAPMLPSPGKPASYSPHMVTPQGGAGTLPLSQASSSLSTTVTTLSSAVGTLHPSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 INPCSAAPMLPSPGKPASYSPHMVTPQGGAGTLPLSQASSSLSTTVTTLSSAVGTLHPSR
370 380 390 400 410 420
400 410 420 430 440 450
pF1KB9 TAGGGGGGGGAAPPLNSIPSVTPPPPATTNSTNPSPQGSHSAIGLSGLNPSTGPGLWWNP
:::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TAGGGGGGGGAAPPLNSIPSVTPPPPATTNSTNPSPQGSHSAIGLSGLNPSTGSTMVGLS
430 440 450 460 470 480
460
pF1KB9 APYQP
XP_016 SGLSPALMSNNPLATIQALASGGTLPLTSLDGSGNLVLGAAGAAPGSPGLVTSPLFLNHA
490 500 510 520 530 540
>>NP_001234923 (OMIM: 164176) POU domain, class 2, trans (400 aa)
initn: 2698 init1: 2590 opt: 2590 Z-score: 1457.2 bits: 278.7 E(85289): 2e-74
Smith-Waterman score: 2590; 99.5% identity (99.7% similar) in 386 aa overlap (1-386:1-386)
10 20 30 40 50 60
pF1KB9 MVHSSMGAPEIRMSKPLEAEKQGLDSPSEHTDTERNGPDTNHQNPQNKTSPFSVSPTGPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MVHSSMGAPEIRMSKPLEAEKQGLDSPSEHTDTERNGPDTNHQNPQNKTSPFSVSPTGPS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB9 TKIKAEDPSGDSAPAAPLPPQPAQPHLPQAQLMLTGSQLAGDIQQLLQLQQLVLVPGHHL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TKIKAEDPSGDSAPAAPLPPQPAQPHLPQAQLMLTGSQLAGDIQQLLQLQQLVLVPGHHL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB9 QPPAQFLLPQAQQSQPGLLPTPNLFQLPQQTQGALLTSQPRAGLPTQPPKCLEPPSHPEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QPPAQFLLPQAQQSQPGLLPTPNLFQLPQQTQGALLTSQPRAGLPTQPPKCLEPPSHPEE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB9 PSDLEELEQFARTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMCK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PSDLEELEQFARTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMCK
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB9 LKPLLEKWLNDAETMSVDSSLPSPNQLSSPSLGFDGLPGRRRKKRTSIETNVRFALEKSF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LKPLLEKWLNDAETMSVDSSLPSPNQLSSPSLGFDGLPGRRRKKRTSIETNVRFALEKSF
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB9 LANQKPTSEEILLIAEQLHMEKEVIRVWFCNRRQKEKRINPCSAAPMLPSPGKPASYSPH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LANQKPTSEEILLIAEQLHMEKEVIRVWFCNRRQKEKRINPCSAAPMLPSPGKPASYSPH
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB9 MVTPQGGAGTLPLSQASSSLSTTVTTLSSAVGTLHPSRTAGGGGGGGGAAPPLNSIPSVT
:::::::::::::::::::::::. :
NP_001 MVTPQGGAGTLPLSQASSSLSTTAQTPALKAATRLSACQA
370 380 390 400
>>XP_016882380 (OMIM: 164176) PREDICTED: POU domain, cla (707 aa)
initn: 2786 init1: 2374 opt: 2414 Z-score: 1356.6 bits: 260.9 E(85289): 8e-69
Smith-Waterman score: 2414; 84.4% identity (90.4% similar) in 436 aa overlap (18-451:138-572)
10 20 30 40
pF1KB9 MVHSSMGAPEIRMSKPLEAEKQGLDSPSEHTDTERNGPDTNHQNPQN
.:. : : . ..... . . .
XP_016 HLPQAQLMLTGSQLAGLTALMPAQQQLLLQQAQAQLLAAAVQQSSAAAAANAAAAAAAAS
110 120 130 140 150 160
50 60 70 80 90 100
pF1KB9 KTSPFSVSPTGPSTKIKAEDPSGDSAPAAPLPPQPAQ--PHLPQAQLMLTGSQLAGDIQQ
.: : : .. ... .. :..... : :::::. : :: : . : ::::
XP_016 ASSSTSSSSSSSASSSTSQPPASSGGGDLP-PPQPASQPPGTPQLTLSQPIQLTAQDIQQ
170 180 190 200 210 220
110 120 130 140 150 160
pF1KB9 LLQLQQLVLVPGHHLQPPAQFLLPQAQQSQPGLLPTPNLFQLPQQTQGALLTSQPRAGLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLQLQQLVLVPGHHLQPPAQFLLPQAQQSQPGLLPTPNLFQLPQQTQGALLTSQPRAGLP
230 240 250 260 270 280
170 180 190 200 210 220
pF1KB9 TQPPKCLEPPSHPEEPSDLEELEQFARTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TQPPKCLEPPSHPEEPSDLEELEQFARTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTI
290 300 310 320 330 340
230 240 250 260 270 280
pF1KB9 SRFEALNLSFKNMCKLKPLLEKWLNDAETMSVDSSLPSPNQLSSPSLGFDGLPGRRRKKR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SRFEALNLSFKNMCKLKPLLEKWLNDAETMSVDSSLPSPNQLSSPSLGFDGLPGRRRKKR
350 360 370 380 390 400
290 300 310 320 330 340
pF1KB9 TSIETNVRFALEKSFLANQKPTSEEILLIAEQLHMEKEVIRVWFCNRRQKEKRINPCSAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TSIETNVRFALEKSFLANQKPTSEEILLIAEQLHMEKEVIRVWFCNRRQKEKRINPCSAA
410 420 430 440 450 460
350 360 370 380 390 400
pF1KB9 PMLPSPGKPASYSPHMVTPQGGAGTLPLSQASSSLSTTVTTLSSAVGTLHPSRTAGGGGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PMLPSPGKPASYSPHMVTPQGGAGTLPLSQASSSLSTTVTTLSSAVGTLHPSRTAGGGGG
470 480 490 500 510 520
410 420 430 440 450 460
pF1KB9 GGGAAPPLNSIPSVTPPPPATTNSTNPSPQGSHSAIGLSGLNPSTGPGLWWNPAPYQP
::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GGGAAPPLNSIPSVTPPPPATTNSTNPSPQGSHSAIGLSGLNPSTGSTMVGLSSGLSPAL
530 540 550 560 570 580
XP_016 MSNNPLATIQALASGGTLPLTSLDGSGNLVLGAAGAAPGSPGLVTSPLFLNHAGLPLLST
590 600 610 620 630 640
>--
initn: 740 init1: 426 opt: 441 Z-score: 262.7 bits: 58.5 E(85289): 6.8e-08
Smith-Waterman score: 650; 77.2% identity (78.7% similar) in 136 aa overlap (1-114:1-136)
10 20 30 40 50 60
pF1KB9 MVHSSMGAPEIRMSKPLEAEKQGLDSPSEHTDTERNGPDTNHQNPQNKTSPFSVSPTGPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MVHSSMGAPEIRMSKPLEAEKQGLDSPSEHTDTERNGPDTNHQNPQNKTSPFSVSPTGPS
10 20 30 40 50 60
70 80 90
pF1KB9 TK----------------------IKAEDPSGDSAPAAPLPPQPAQPHLPQAQLMLTGSQ
:: ::::::::::::::::::::::::::::::::::::
XP_016 TKVGILSGLHLTFWGPGPCLSPPQIKAEDPSGDSAPAAPLPPQPAQPHLPQAQLMLTGSQ
70 80 90 100 110 120
100 110 120 130 140 150
pF1KB9 LAGDIQQLLQLQQLVLVPGHHLQPPAQFLLPQAQQSQPGLLPTPNLFQLPQQTQGALLTS
::: . :::.:
XP_016 LAGLTALMPAQQQLLLQQAQAQLLAAAVQQSSAAAAANAAAAAAAASASSSTSSSSSSSA
130 140 150 160 170 180
>>NP_001193954 (OMIM: 164176) POU domain, class 2, trans (479 aa)
initn: 2019 init1: 2019 opt: 2113 Z-score: 1191.8 bits: 229.9 E(85289): 1.2e-59
Smith-Waterman score: 3110; 96.7% identity (96.7% similar) in 479 aa overlap (1-463:1-479)
10 20 30 40 50 60
pF1KB9 MVHSSMGAPEIRMSKPLEAEKQGLDSPSEHTDTERNGPDTNHQNPQNKTSPFSVSPTGPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MVHSSMGAPEIRMSKPLEAEKQGLDSPSEHTDTERNGPDTNHQNPQNKTSPFSVSPTGPS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB9 TKIKAEDPSGDSAPAAPLPPQPAQPHLPQAQLMLTGSQLAGDIQQLLQLQQLVLVPGHHL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TKIKAEDPSGDSAPAAPLPPQPAQPHLPQAQLMLTGSQLAGDIQQLLQLQQLVLVPGHHL
70 80 90 100 110 120
130 140 150 160
pF1KB9 QPPAQFLLPQAQQSQPGLLPTPNLFQLPQQTQGALLTSQPRAGLPTQ-------------
:::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QPPAQFLLPQAQQSQPGLLPTPNLFQLPQQTQGALLTSQPRAGLPTQAVTRPTLPDPHLS
130 140 150 160 170 180
170 180 190 200 210 220
pF1KB9 ---PPKCLEPPSHPEEPSDLEELEQFARTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTT
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HPQPPKCLEPPSHPEEPSDLEELEQFARTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTT
190 200 210 220 230 240
230 240 250 260 270 280
pF1KB9 ISRFEALNLSFKNMCKLKPLLEKWLNDAETMSVDSSLPSPNQLSSPSLGFDGLPGRRRKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ISRFEALNLSFKNMCKLKPLLEKWLNDAETMSVDSSLPSPNQLSSPSLGFDGLPGRRRKK
250 260 270 280 290 300
290 300 310 320 330 340
pF1KB9 RTSIETNVRFALEKSFLANQKPTSEEILLIAEQLHMEKEVIRVWFCNRRQKEKRINPCSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RTSIETNVRFALEKSFLANQKPTSEEILLIAEQLHMEKEVIRVWFCNRRQKEKRINPCSA
310 320 330 340 350 360
350 360 370 380 390 400
pF1KB9 APMLPSPGKPASYSPHMVTPQGGAGTLPLSQASSSLSTTVTTLSSAVGTLHPSRTAGGGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 APMLPSPGKPASYSPHMVTPQGGAGTLPLSQASSSLSTTVTTLSSAVGTLHPSRTAGGGG
370 380 390 400 410 420
410 420 430 440 450 460
pF1KB9 GGGGAAPPLNSIPSVTPPPPATTNSTNPSPQGSHSAIGLSGLNPSTGPGLWWNPAPYQP
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GGGGAAPPLNSIPSVTPPPPATTNSTNPSPQGSHSAIGLSGLNPSTGPGLWWNPAPYQP
430 440 450 460 470
>>XP_016882385 (OMIM: 164176) PREDICTED: POU domain, cla (600 aa)
initn: 2745 init1: 2019 opt: 2111 Z-score: 1189.5 bits: 229.8 E(85289): 1.6e-59
Smith-Waterman score: 2482; 81.9% identity (87.5% similar) in 464 aa overlap (18-463:138-600)
10 20 30 40
pF1KB9 MVHSSMGAPEIRMSKPLEAEKQGLDSPSEHTDTERNGPDTNHQNPQN
.:. : : . ..... . . .
XP_016 HLPQAQLMLTGSQLAGLTALMPAQQQLLLQQAQAQLLAAAVQQSSAAAAANAAAAAAAAS
110 120 130 140 150 160
50 60 70 80 90 100
pF1KB9 KTSPFSVSPTGPSTKIKAEDPSGDSAPAAPLPPQPAQ--PHLPQAQLMLTGSQLAGDIQQ
.: : : .. ... .. :..... : :::::. : :: : . : ::::
XP_016 ASSSTSSSSSSSASSSTSQPPASSGGGDLP-PPQPASQPPGTPQLTLSQPIQLTAQDIQQ
170 180 190 200 210 220
110 120 130 140 150 160
pF1KB9 LLQLQQLVLVPGHHLQPPAQFLLPQAQQSQPGLLPTPNLFQLPQQTQGALLTSQPRAGLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLQLQQLVLVPGHHLQPPAQFLLPQAQQSQPGLLPTPNLFQLPQQTQGALLTSQPRAGLP
230 240 250 260 270 280
170 180 190 200
pF1KB9 TQ----------------PPKCLEPPSHPEEPSDLEELEQFARTFKQRRIKLGFTQGDVG
:: ::::::::::::::::::::::::::::::::::::::::::
XP_016 TQAVTRPTLPDPHLSHPQPPKCLEPPSHPEEPSDLEELEQFARTFKQRRIKLGFTQGDVG
290 300 310 320 330 340
210 220 230 240 250 260
pF1KB9 LAMGKLYGNDFSQTTISRFEALNLSFKNMCKLKPLLEKWLNDAETMSVDSSLPSPNQLSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LAMGKLYGNDFSQTTISRFEALNLSFKNMCKLKPLLEKWLNDAETMSVDSSLPSPNQLSS
350 360 370 380 390 400
270 280 290 300 310 320
pF1KB9 PSLGFDGLPGRRRKKRTSIETNVRFALEKSFLANQKPTSEEILLIAEQLHMEKEVIRVWF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PSLGFDGLPGRRRKKRTSIETNVRFALEKSFLANQKPTSEEILLIAEQLHMEKEVIRVWF
410 420 430 440 450 460
330 340 350 360 370 380
pF1KB9 CNRRQKEKRINPCSAAPMLPSPGKPASYSPHMVTPQGGAGTLPLSQASSSLSTTVTTLSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CNRRQKEKRINPCSAAPMLPSPGKPASYSPHMVTPQGGAGTLPLSQASSSLSTTVTTLSS
470 480 490 500 510 520
390 400 410 420 430 440
pF1KB9 AVGTLHPSRTAGGGGGGGGAAPPLNSIPSVTPPPPATTNSTNPSPQGSHSAIGLSGLNPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AVGTLHPSRTAGGGGGGGGAAPPLNSIPSVTPPPPATTNSTNPSPQGSHSAIGLSGLNPS
530 540 550 560 570 580
450 460
pF1KB9 TGPGLWWNPAPYQP
::::::::::::::
XP_016 TGPGLWWNPAPYQP
590 600
>--
initn: 740 init1: 426 opt: 441 Z-score: 263.6 bits: 58.4 E(85289): 6.1e-08
Smith-Waterman score: 650; 77.2% identity (78.7% similar) in 136 aa overlap (1-114:1-136)
10 20 30 40 50 60
pF1KB9 MVHSSMGAPEIRMSKPLEAEKQGLDSPSEHTDTERNGPDTNHQNPQNKTSPFSVSPTGPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MVHSSMGAPEIRMSKPLEAEKQGLDSPSEHTDTERNGPDTNHQNPQNKTSPFSVSPTGPS
10 20 30 40 50 60
70 80 90
pF1KB9 TK----------------------IKAEDPSGDSAPAAPLPPQPAQPHLPQAQLMLTGSQ
:: ::::::::::::::::::::::::::::::::::::
XP_016 TKVGILSGLHLTFWGPGPCLSPPQIKAEDPSGDSAPAAPLPPQPAQPHLPQAQLMLTGSQ
70 80 90 100 110 120
100 110 120 130 140 150
pF1KB9 LAGDIQQLLQLQQLVLVPGHHLQPPAQFLLPQAQQSQPGLLPTPNLFQLPQQTQGALLTS
::: . :::.:
XP_016 LAGLTALMPAQQQLLLQQAQAQLLAAAVQQSSAAAAANAAAAAAAASASSSTSSSSSSSA
130 140 150 160 170 180
>>XP_011525343 (OMIM: 164176) PREDICTED: POU domain, cla (501 aa)
initn: 2477 init1: 2019 opt: 2104 Z-score: 1186.6 bits: 229.0 E(85289): 2.4e-59
Smith-Waterman score: 3017; 92.3% identity (92.3% similar) in 495 aa overlap (7-463:7-501)
10 20 30 40 50 60
pF1KB9 MVHSSMGAPEIRMSKPLEAEKQGLDSPSEHTDTERNGPDTNHQNPQNKTSPFSVSPTGPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MVHSSMGAPEIRMSKPLEAEKQGLDSPSEHTDTERNGPDTNHQNPQNKTSPFSVSPTGPS
10 20 30 40 50 60
70 80 90
pF1KB9 TK----------------------IKAEDPSGDSAPAAPLPPQPAQPHLPQAQLMLTGSQ
:: ::::::::::::::::::::::::::::::::::::
XP_011 TKVGILSGLHLTFWGPGPCLSPPQIKAEDPSGDSAPAAPLPPQPAQPHLPQAQLMLTGSQ
70 80 90 100 110 120
100 110 120 130 140 150
pF1KB9 LAGDIQQLLQLQQLVLVPGHHLQPPAQFLLPQAQQSQPGLLPTPNLFQLPQQTQGALLTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LAGDIQQLLQLQQLVLVPGHHLQPPAQFLLPQAQQSQPGLLPTPNLFQLPQQTQGALLTS
130 140 150 160 170 180
160 170 180 190 200
pF1KB9 QPRAGLPTQ----------------PPKCLEPPSHPEEPSDLEELEQFARTFKQRRIKLG
::::::::: :::::::::::::::::::::::::::::::::::
XP_011 QPRAGLPTQAVTRPTLPDPHLSHPQPPKCLEPPSHPEEPSDLEELEQFARTFKQRRIKLG
190 200 210 220 230 240
210 220 230 240 250 260
pF1KB9 FTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMCKLKPLLEKWLNDAETMSVDSSLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMCKLKPLLEKWLNDAETMSVDSSLP
250 260 270 280 290 300
270 280 290 300 310 320
pF1KB9 SPNQLSSPSLGFDGLPGRRRKKRTSIETNVRFALEKSFLANQKPTSEEILLIAEQLHMEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SPNQLSSPSLGFDGLPGRRRKKRTSIETNVRFALEKSFLANQKPTSEEILLIAEQLHMEK
310 320 330 340 350 360
330 340 350 360 370 380
pF1KB9 EVIRVWFCNRRQKEKRINPCSAAPMLPSPGKPASYSPHMVTPQGGAGTLPLSQASSSLST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EVIRVWFCNRRQKEKRINPCSAAPMLPSPGKPASYSPHMVTPQGGAGTLPLSQASSSLST
370 380 390 400 410 420
390 400 410 420 430 440
pF1KB9 TVTTLSSAVGTLHPSRTAGGGGGGGGAAPPLNSIPSVTPPPPATTNSTNPSPQGSHSAIG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TVTTLSSAVGTLHPSRTAGGGGGGGGAAPPLNSIPSVTPPPPATTNSTNPSPQGSHSAIG
430 440 450 460 470 480
450 460
pF1KB9 LSGLNPSTGPGLWWNPAPYQP
:::::::::::::::::::::
XP_011 LSGLNPSTGPGLWWNPAPYQP
490 500
>>NP_001193955 (OMIM: 164176) POU domain, class 2, trans (467 aa)
initn: 1909 init1: 1909 opt: 2003 Z-score: 1130.9 bits: 218.6 E(85289): 3e-56
Smith-Waterman score: 3000; 96.6% identity (96.6% similar) in 467 aa overlap (1-451:1-467)
10 20 30 40 50 60
pF1KB9 MVHSSMGAPEIRMSKPLEAEKQGLDSPSEHTDTERNGPDTNHQNPQNKTSPFSVSPTGPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MVHSSMGAPEIRMSKPLEAEKQGLDSPSEHTDTERNGPDTNHQNPQNKTSPFSVSPTGPS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB9 TKIKAEDPSGDSAPAAPLPPQPAQPHLPQAQLMLTGSQLAGDIQQLLQLQQLVLVPGHHL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TKIKAEDPSGDSAPAAPLPPQPAQPHLPQAQLMLTGSQLAGDIQQLLQLQQLVLVPGHHL
70 80 90 100 110 120
130 140 150 160
pF1KB9 QPPAQFLLPQAQQSQPGLLPTPNLFQLPQQTQGALLTSQPRAGLPTQ-------------
:::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QPPAQFLLPQAQQSQPGLLPTPNLFQLPQQTQGALLTSQPRAGLPTQAVTRPTLPDPHLS
130 140 150 160 170 180
170 180 190 200 210 220
pF1KB9 ---PPKCLEPPSHPEEPSDLEELEQFARTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTT
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HPQPPKCLEPPSHPEEPSDLEELEQFARTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTT
190 200 210 220 230 240
230 240 250 260 270 280
pF1KB9 ISRFEALNLSFKNMCKLKPLLEKWLNDAETMSVDSSLPSPNQLSSPSLGFDGLPGRRRKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ISRFEALNLSFKNMCKLKPLLEKWLNDAETMSVDSSLPSPNQLSSPSLGFDGLPGRRRKK
250 260 270 280 290 300
290 300 310 320 330 340
pF1KB9 RTSIETNVRFALEKSFLANQKPTSEEILLIAEQLHMEKEVIRVWFCNRRQKEKRINPCSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RTSIETNVRFALEKSFLANQKPTSEEILLIAEQLHMEKEVIRVWFCNRRQKEKRINPCSA
310 320 330 340 350 360
350 360 370 380 390 400
pF1KB9 APMLPSPGKPASYSPHMVTPQGGAGTLPLSQASSSLSTTVTTLSSAVGTLHPSRTAGGGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 APMLPSPGKPASYSPHMVTPQGGAGTLPLSQASSSLSTTVTTLSSAVGTLHPSRTAGGGG
370 380 390 400 410 420
410 420 430 440 450 460
pF1KB9 GGGGAAPPLNSIPSVTPPPPATTNSTNPSPQGSHSAIGLSGLNPSTGPGLWWNPAPYQP
:::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GGGGAAPPLNSIPSVTPPPPATTNSTNPSPQGSHSAIGLSGLNPSTG
430 440 450 460
463 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 12:11:11 2016 done: Sun Nov 6 12:11:12 2016
Total Scan time: 11.510 Total Display time: 0.120
Function used was FASTA [36.3.4 Apr, 2011]