Result of FASTA (omim) for
pFN21AE3335
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE3335, 974 aa
1>>>pF1KE3335 974 - 974 aa - 974 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 11.9852+/-0.000566; mu= -10.4046+/- 0.034
mean_var=743.9407+/-165.852, 0's: 0 Z-trim(118.7): 360 B-trim: 0 in 0/56
Lambda= 0.047022
statistics sampled from 31593 (32011) to 31593 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.711), E-opt: 0.2 (0.375), width: 16
Scan time: 9.720
The best scores are: opt bits E(85289)
NP_150296 (OMIM: 604034) serine/threonine-protein ( 926) 6305 444.9 9e-124
XP_011544010 (OMIM: 604034) PREDICTED: serine/thre ( 782) 5337 379.1 4.8e-104
XP_011544011 (OMIM: 604034) PREDICTED: serine/thre ( 782) 5337 379.1 4.8e-104
XP_011544013 (OMIM: 604034) PREDICTED: serine/thre ( 573) 3430 249.6 3.6e-65
NP_001295149 (OMIM: 604034) serine/threonine-prote ( 874) 3251 237.7 2e-61
XP_011544015 (OMIM: 604034) PREDICTED: serine/thre ( 555) 3056 224.2 1.5e-57
XP_011544014 (OMIM: 604034) PREDICTED: serine/thre ( 557) 3056 224.2 1.5e-57
NP_001424 (OMIM: 604033) serine/threonine-protein ( 977) 1816 140.4 4.4e-32
XP_016879837 (OMIM: 604033) PREDICTED: serine/thre ( 980) 1816 140.4 4.4e-32
XP_016879836 (OMIM: 604033) PREDICTED: serine/thre (1014) 1816 140.4 4.5e-32
>>NP_150296 (OMIM: 604034) serine/threonine-protein kina (926 aa)
initn: 6305 init1: 6305 opt: 6305 Z-score: 2343.1 bits: 444.9 E(85289): 9e-124
Smith-Waterman score: 6305; 100.0% identity (100.0% similar) in 926 aa overlap (49-974:1-926)
20 30 40 50 60 70
pF1KE3 GAEPSPGRAGTERSLGGTQGPGQPCSCPGAMASAVRGSRPWPRLGLQLQFAALLLGTLSP
::::::::::::::::::::::::::::::
NP_150 MASAVRGSRPWPRLGLQLQFAALLLGTLSP
10 20 30
80 90 100 110 120 130
pF1KE3 QVHTLRPENLLLVSTLDGSLHALSKQTGDLKWTLRDDPVIEGPMYVTEMAFLSDPADGSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_150 QVHTLRPENLLLVSTLDGSLHALSKQTGDLKWTLRDDPVIEGPMYVTEMAFLSDPADGSL
40 50 60 70 80 90
140 150 160 170 180 190
pF1KE3 YILGTQKQQGLMKLPFTIPELVHASPCRSSDGVFYTGRKQDAWFVVDPESGETQMTLTTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_150 YILGTQKQQGLMKLPFTIPELVHASPCRSSDGVFYTGRKQDAWFVVDPESGETQMTLTTE
100 110 120 130 140 150
200 210 220 230 240 250
pF1KE3 GPSTPRLYIGRTQYTVTMHDPRAPALRWNTTYRRYSAPPMDGSPGKYMSHLASCGMGLLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_150 GPSTPRLYIGRTQYTVTMHDPRAPALRWNTTYRRYSAPPMDGSPGKYMSHLASCGMGLLL
160 170 180 190 200 210
260 270 280 290 300 310
pF1KE3 TVDPGSGTVLWTQDLGVPVMGVYTWHQDGLRQLPHLTLARDTLHFLALRWGHIRLPASGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_150 TVDPGSGTVLWTQDLGVPVMGVYTWHQDGLRQLPHLTLARDTLHFLALRWGHIRLPASGP
220 230 240 250 260 270
320 330 340 350 360 370
pF1KE3 RDTATLFSTLDTQLLMTLYVGKDETGFYVSKALVHTGVALVPRGLTLAPADGPTTDEVTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_150 RDTATLFSTLDTQLLMTLYVGKDETGFYVSKALVHTGVALVPRGLTLAPADGPTTDEVTL
280 290 300 310 320 330
380 390 400 410 420 430
pF1KE3 QVSGEREGSPSTAVRYPSGSVALPSQWLLIGHHELPPVLHTTMLRVHPTLGSGTAETRPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_150 QVSGEREGSPSTAVRYPSGSVALPSQWLLIGHHELPPVLHTTMLRVHPTLGSGTAETRPP
340 350 360 370 380 390
440 450 460 470 480 490
pF1KE3 ENTQAPAFFLELLSLSREKLWDSELHPEEKTPDSYLGLGPQDLLAASLTAVLLGGWILFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_150 ENTQAPAFFLELLSLSREKLWDSELHPEEKTPDSYLGLGPQDLLAASLTAVLLGGWILFV
400 410 420 430 440 450
500 510 520 530 540 550
pF1KE3 MRQQQPQVVEKQQETPLAPADFAHISQDAQSLHSGASRRSQKRLQSPSKQAQPLDDPEAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_150 MRQQQPQVVEKQQETPLAPADFAHISQDAQSLHSGASRRSQKRLQSPSKQAQPLDDPEAE
460 470 480 490 500 510
560 570 580 590 600 610
pF1KE3 QLTVVGKISFNPKDVLGRGAGGTFVFRGQFEGRAVAVKRLLRECFGLVRREVQLLQESDR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_150 QLTVVGKISFNPKDVLGRGAGGTFVFRGQFEGRAVAVKRLLRECFGLVRREVQLLQESDR
520 530 540 550 560 570
620 630 640 650 660 670
pF1KE3 HPNVLRYFCTERGPQFHYIALELCRASLQEYVENPDLDRGGLEPEVVLQQLMSGLAHLHS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_150 HPNVLRYFCTERGPQFHYIALELCRASLQEYVENPDLDRGGLEPEVVLQQLMSGLAHLHS
580 590 600 610 620 630
680 690 700 710 720 730
pF1KE3 LHIVHRDLKPGNILITGPDSQGLGRVVLSDFGLCKKLPAGRCSFSLHSGIPGTEGWMAPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_150 LHIVHRDLKPGNILITGPDSQGLGRVVLSDFGLCKKLPAGRCSFSLHSGIPGTEGWMAPE
640 650 660 670 680 690
740 750 760 770 780 790
pF1KE3 LLQLLPPDSPTSAVDIFSAGCVFYYVLSGGSHPFGDSLYRQANILTGAPCLAHLEEEVHD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_150 LLQLLPPDSPTSAVDIFSAGCVFYYVLSGGSHPFGDSLYRQANILTGAPCLAHLEEEVHD
700 710 720 730 740 750
800 810 820 830 840 850
pF1KE3 KVVARDLVGAMLSPLPQPRPSAPQVLAHPFFWSRAKQLQFFQDVSDWLEKESEQEPLVRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_150 KVVARDLVGAMLSPLPQPRPSAPQVLAHPFFWSRAKQLQFFQDVSDWLEKESEQEPLVRA
760 770 780 790 800 810
860 870 880 890 900 910
pF1KE3 LEAGGCAVVRDNWHEHISMPLQTDLRKFRSYKGTSVRDLLRAVRNKKHHYRELPVEVRQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_150 LEAGGCAVVRDNWHEHISMPLQTDLRKFRSYKGTSVRDLLRAVRNKKHHYRELPVEVRQA
820 830 840 850 860 870
920 930 940 950 960 970
pF1KE3 LGQVPDGFVQYFTNRFPRLLLHTHRAMRSCASESLFLPYYPPDSEARRPCPGATGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_150 LGQVPDGFVQYFTNRFPRLLLHTHRAMRSCASESLFLPYYPPDSEARRPCPGATGR
880 890 900 910 920
>>XP_011544010 (OMIM: 604034) PREDICTED: serine/threonin (782 aa)
initn: 5337 init1: 5337 opt: 5337 Z-score: 1988.9 bits: 379.1 E(85289): 4.8e-104
Smith-Waterman score: 5337; 100.0% identity (100.0% similar) in 782 aa overlap (193-974:1-782)
170 180 190 200 210 220
pF1KE3 SPCRSSDGVFYTGRKQDAWFVVDPESGETQMTLTTEGPSTPRLYIGRTQYTVTMHDPRAP
::::::::::::::::::::::::::::::
XP_011 MTLTTEGPSTPRLYIGRTQYTVTMHDPRAP
10 20 30
230 240 250 260 270 280
pF1KE3 ALRWNTTYRRYSAPPMDGSPGKYMSHLASCGMGLLLTVDPGSGTVLWTQDLGVPVMGVYT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ALRWNTTYRRYSAPPMDGSPGKYMSHLASCGMGLLLTVDPGSGTVLWTQDLGVPVMGVYT
40 50 60 70 80 90
290 300 310 320 330 340
pF1KE3 WHQDGLRQLPHLTLARDTLHFLALRWGHIRLPASGPRDTATLFSTLDTQLLMTLYVGKDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WHQDGLRQLPHLTLARDTLHFLALRWGHIRLPASGPRDTATLFSTLDTQLLMTLYVGKDE
100 110 120 130 140 150
350 360 370 380 390 400
pF1KE3 TGFYVSKALVHTGVALVPRGLTLAPADGPTTDEVTLQVSGEREGSPSTAVRYPSGSVALP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TGFYVSKALVHTGVALVPRGLTLAPADGPTTDEVTLQVSGEREGSPSTAVRYPSGSVALP
160 170 180 190 200 210
410 420 430 440 450 460
pF1KE3 SQWLLIGHHELPPVLHTTMLRVHPTLGSGTAETRPPENTQAPAFFLELLSLSREKLWDSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SQWLLIGHHELPPVLHTTMLRVHPTLGSGTAETRPPENTQAPAFFLELLSLSREKLWDSE
220 230 240 250 260 270
470 480 490 500 510 520
pF1KE3 LHPEEKTPDSYLGLGPQDLLAASLTAVLLGGWILFVMRQQQPQVVEKQQETPLAPADFAH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LHPEEKTPDSYLGLGPQDLLAASLTAVLLGGWILFVMRQQQPQVVEKQQETPLAPADFAH
280 290 300 310 320 330
530 540 550 560 570 580
pF1KE3 ISQDAQSLHSGASRRSQKRLQSPSKQAQPLDDPEAEQLTVVGKISFNPKDVLGRGAGGTF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ISQDAQSLHSGASRRSQKRLQSPSKQAQPLDDPEAEQLTVVGKISFNPKDVLGRGAGGTF
340 350 360 370 380 390
590 600 610 620 630 640
pF1KE3 VFRGQFEGRAVAVKRLLRECFGLVRREVQLLQESDRHPNVLRYFCTERGPQFHYIALELC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VFRGQFEGRAVAVKRLLRECFGLVRREVQLLQESDRHPNVLRYFCTERGPQFHYIALELC
400 410 420 430 440 450
650 660 670 680 690 700
pF1KE3 RASLQEYVENPDLDRGGLEPEVVLQQLMSGLAHLHSLHIVHRDLKPGNILITGPDSQGLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RASLQEYVENPDLDRGGLEPEVVLQQLMSGLAHLHSLHIVHRDLKPGNILITGPDSQGLG
460 470 480 490 500 510
710 720 730 740 750 760
pF1KE3 RVVLSDFGLCKKLPAGRCSFSLHSGIPGTEGWMAPELLQLLPPDSPTSAVDIFSAGCVFY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RVVLSDFGLCKKLPAGRCSFSLHSGIPGTEGWMAPELLQLLPPDSPTSAVDIFSAGCVFY
520 530 540 550 560 570
770 780 790 800 810 820
pF1KE3 YVLSGGSHPFGDSLYRQANILTGAPCLAHLEEEVHDKVVARDLVGAMLSPLPQPRPSAPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YVLSGGSHPFGDSLYRQANILTGAPCLAHLEEEVHDKVVARDLVGAMLSPLPQPRPSAPQ
580 590 600 610 620 630
830 840 850 860 870 880
pF1KE3 VLAHPFFWSRAKQLQFFQDVSDWLEKESEQEPLVRALEAGGCAVVRDNWHEHISMPLQTD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VLAHPFFWSRAKQLQFFQDVSDWLEKESEQEPLVRALEAGGCAVVRDNWHEHISMPLQTD
640 650 660 670 680 690
890 900 910 920 930 940
pF1KE3 LRKFRSYKGTSVRDLLRAVRNKKHHYRELPVEVRQALGQVPDGFVQYFTNRFPRLLLHTH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LRKFRSYKGTSVRDLLRAVRNKKHHYRELPVEVRQALGQVPDGFVQYFTNRFPRLLLHTH
700 710 720 730 740 750
950 960 970
pF1KE3 RAMRSCASESLFLPYYPPDSEARRPCPGATGR
::::::::::::::::::::::::::::::::
XP_011 RAMRSCASESLFLPYYPPDSEARRPCPGATGR
760 770 780
>>XP_011544011 (OMIM: 604034) PREDICTED: serine/threonin (782 aa)
initn: 5337 init1: 5337 opt: 5337 Z-score: 1988.9 bits: 379.1 E(85289): 4.8e-104
Smith-Waterman score: 5337; 100.0% identity (100.0% similar) in 782 aa overlap (193-974:1-782)
170 180 190 200 210 220
pF1KE3 SPCRSSDGVFYTGRKQDAWFVVDPESGETQMTLTTEGPSTPRLYIGRTQYTVTMHDPRAP
::::::::::::::::::::::::::::::
XP_011 MTLTTEGPSTPRLYIGRTQYTVTMHDPRAP
10 20 30
230 240 250 260 270 280
pF1KE3 ALRWNTTYRRYSAPPMDGSPGKYMSHLASCGMGLLLTVDPGSGTVLWTQDLGVPVMGVYT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ALRWNTTYRRYSAPPMDGSPGKYMSHLASCGMGLLLTVDPGSGTVLWTQDLGVPVMGVYT
40 50 60 70 80 90
290 300 310 320 330 340
pF1KE3 WHQDGLRQLPHLTLARDTLHFLALRWGHIRLPASGPRDTATLFSTLDTQLLMTLYVGKDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WHQDGLRQLPHLTLARDTLHFLALRWGHIRLPASGPRDTATLFSTLDTQLLMTLYVGKDE
100 110 120 130 140 150
350 360 370 380 390 400
pF1KE3 TGFYVSKALVHTGVALVPRGLTLAPADGPTTDEVTLQVSGEREGSPSTAVRYPSGSVALP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TGFYVSKALVHTGVALVPRGLTLAPADGPTTDEVTLQVSGEREGSPSTAVRYPSGSVALP
160 170 180 190 200 210
410 420 430 440 450 460
pF1KE3 SQWLLIGHHELPPVLHTTMLRVHPTLGSGTAETRPPENTQAPAFFLELLSLSREKLWDSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SQWLLIGHHELPPVLHTTMLRVHPTLGSGTAETRPPENTQAPAFFLELLSLSREKLWDSE
220 230 240 250 260 270
470 480 490 500 510 520
pF1KE3 LHPEEKTPDSYLGLGPQDLLAASLTAVLLGGWILFVMRQQQPQVVEKQQETPLAPADFAH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LHPEEKTPDSYLGLGPQDLLAASLTAVLLGGWILFVMRQQQPQVVEKQQETPLAPADFAH
280 290 300 310 320 330
530 540 550 560 570 580
pF1KE3 ISQDAQSLHSGASRRSQKRLQSPSKQAQPLDDPEAEQLTVVGKISFNPKDVLGRGAGGTF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ISQDAQSLHSGASRRSQKRLQSPSKQAQPLDDPEAEQLTVVGKISFNPKDVLGRGAGGTF
340 350 360 370 380 390
590 600 610 620 630 640
pF1KE3 VFRGQFEGRAVAVKRLLRECFGLVRREVQLLQESDRHPNVLRYFCTERGPQFHYIALELC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VFRGQFEGRAVAVKRLLRECFGLVRREVQLLQESDRHPNVLRYFCTERGPQFHYIALELC
400 410 420 430 440 450
650 660 670 680 690 700
pF1KE3 RASLQEYVENPDLDRGGLEPEVVLQQLMSGLAHLHSLHIVHRDLKPGNILITGPDSQGLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RASLQEYVENPDLDRGGLEPEVVLQQLMSGLAHLHSLHIVHRDLKPGNILITGPDSQGLG
460 470 480 490 500 510
710 720 730 740 750 760
pF1KE3 RVVLSDFGLCKKLPAGRCSFSLHSGIPGTEGWMAPELLQLLPPDSPTSAVDIFSAGCVFY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RVVLSDFGLCKKLPAGRCSFSLHSGIPGTEGWMAPELLQLLPPDSPTSAVDIFSAGCVFY
520 530 540 550 560 570
770 780 790 800 810 820
pF1KE3 YVLSGGSHPFGDSLYRQANILTGAPCLAHLEEEVHDKVVARDLVGAMLSPLPQPRPSAPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YVLSGGSHPFGDSLYRQANILTGAPCLAHLEEEVHDKVVARDLVGAMLSPLPQPRPSAPQ
580 590 600 610 620 630
830 840 850 860 870 880
pF1KE3 VLAHPFFWSRAKQLQFFQDVSDWLEKESEQEPLVRALEAGGCAVVRDNWHEHISMPLQTD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VLAHPFFWSRAKQLQFFQDVSDWLEKESEQEPLVRALEAGGCAVVRDNWHEHISMPLQTD
640 650 660 670 680 690
890 900 910 920 930 940
pF1KE3 LRKFRSYKGTSVRDLLRAVRNKKHHYRELPVEVRQALGQVPDGFVQYFTNRFPRLLLHTH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LRKFRSYKGTSVRDLLRAVRNKKHHYRELPVEVRQALGQVPDGFVQYFTNRFPRLLLHTH
700 710 720 730 740 750
950 960 970
pF1KE3 RAMRSCASESLFLPYYPPDSEARRPCPGATGR
::::::::::::::::::::::::::::::::
XP_011 RAMRSCASESLFLPYYPPDSEARRPCPGATGR
760 770 780
>>XP_011544013 (OMIM: 604034) PREDICTED: serine/threonin (573 aa)
initn: 3430 init1: 3430 opt: 3430 Z-score: 1291.1 bits: 249.6 E(85289): 3.6e-65
Smith-Waterman score: 3430; 99.4% identity (100.0% similar) in 512 aa overlap (49-560:1-512)
20 30 40 50 60 70
pF1KE3 GAEPSPGRAGTERSLGGTQGPGQPCSCPGAMASAVRGSRPWPRLGLQLQFAALLLGTLSP
::::::::::::::::::::::::::::::
XP_011 MASAVRGSRPWPRLGLQLQFAALLLGTLSP
10 20 30
80 90 100 110 120 130
pF1KE3 QVHTLRPENLLLVSTLDGSLHALSKQTGDLKWTLRDDPVIEGPMYVTEMAFLSDPADGSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QVHTLRPENLLLVSTLDGSLHALSKQTGDLKWTLRDDPVIEGPMYVTEMAFLSDPADGSL
40 50 60 70 80 90
140 150 160 170 180 190
pF1KE3 YILGTQKQQGLMKLPFTIPELVHASPCRSSDGVFYTGRKQDAWFVVDPESGETQMTLTTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YILGTQKQQGLMKLPFTIPELVHASPCRSSDGVFYTGRKQDAWFVVDPESGETQMTLTTE
100 110 120 130 140 150
200 210 220 230 240 250
pF1KE3 GPSTPRLYIGRTQYTVTMHDPRAPALRWNTTYRRYSAPPMDGSPGKYMSHLASCGMGLLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GPSTPRLYIGRTQYTVTMHDPRAPALRWNTTYRRYSAPPMDGSPGKYMSHLASCGMGLLL
160 170 180 190 200 210
260 270 280 290 300 310
pF1KE3 TVDPGSGTVLWTQDLGVPVMGVYTWHQDGLRQLPHLTLARDTLHFLALRWGHIRLPASGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TVDPGSGTVLWTQDLGVPVMGVYTWHQDGLRQLPHLTLARDTLHFLALRWGHIRLPASGP
220 230 240 250 260 270
320 330 340 350 360 370
pF1KE3 RDTATLFSTLDTQLLMTLYVGKDETGFYVSKALVHTGVALVPRGLTLAPADGPTTDEVTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RDTATLFSTLDTQLLMTLYVGKDETGFYVSKALVHTGVALVPRGLTLAPADGPTTDEVTL
280 290 300 310 320 330
380 390 400 410 420 430
pF1KE3 QVSGEREGSPSTAVRYPSGSVALPSQWLLIGHHELPPVLHTTMLRVHPTLGSGTAETRPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QVSGEREGSPSTAVRYPSGSVALPSQWLLIGHHELPPVLHTTMLRVHPTLGSGTAETRPP
340 350 360 370 380 390
440 450 460 470 480 490
pF1KE3 ENTQAPAFFLELLSLSREKLWDSELHPEEKTPDSYLGLGPQDLLAASLTAVLLGGWILFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ENTQAPAFFLELLSLSREKLWDSELHPEEKTPDSYLGLGPQDLLAASLTAVLLGGWILFV
400 410 420 430 440 450
500 510 520 530 540 550
pF1KE3 MRQQQPQVVEKQQETPLAPADFAHISQDAQSLHSGASRRSQKRLQSPSKQAQPLDDPEAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::..
XP_011 MRQQQPQVVEKQQETPLAPADFAHISQDAQSLHSGASRRSQKRLQSPSKQAQPLDDPEGD
460 470 480 490 500 510
560 570 580 590 600 610
pF1KE3 QLTVVGKISFNPKDVLGRGAGGTFVFRGQFEGRAVAVKRLLRECFGLVRREVQLLQESDR
.:
XP_011 SLRDGQWLSSGSSASALAWFGGKFNCCRSLTGTPTCSATSAPSGDPSSTTLPWSSAGPPC
520 530 540 550 560 570
>>NP_001295149 (OMIM: 604034) serine/threonine-protein k (874 aa)
initn: 3251 init1: 3251 opt: 3251 Z-score: 1223.6 bits: 237.7 E(85289): 2e-61
Smith-Waterman score: 5848; 94.4% identity (94.4% similar) in 926 aa overlap (49-974:1-874)
20 30 40 50 60 70
pF1KE3 GAEPSPGRAGTERSLGGTQGPGQPCSCPGAMASAVRGSRPWPRLGLQLQFAALLLGTLSP
::::::::::::::::::::::::::::::
NP_001 MASAVRGSRPWPRLGLQLQFAALLLGTLSP
10 20 30
80 90 100 110 120 130
pF1KE3 QVHTLRPENLLLVSTLDGSLHALSKQTGDLKWTLRDDPVIEGPMYVTEMAFLSDPADGSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QVHTLRPENLLLVSTLDGSLHALSKQTGDLKWTLRDDPVIEGPMYVTEMAFLSDPADGSL
40 50 60 70 80 90
140 150 160 170 180 190
pF1KE3 YILGTQKQQGLMKLPFTIPELVHASPCRSSDGVFYTGRKQDAWFVVDPESGETQMTLTTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YILGTQKQQGLMKLPFTIPELVHASPCRSSDGVFYTGRKQDAWFVVDPESGETQMTLTTE
100 110 120 130 140 150
200 210 220 230 240 250
pF1KE3 GPSTPRLYIGRTQYTVTMHDPRAPALRWNTTYRRYSAPPMDGSPGKYMSHLASCGMGLLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GPSTPRLYIGRTQYTVTMHDPRAPALRWNTTYRRYSAPPMDGSPGKYMSHLASCGMGLLL
160 170 180 190 200 210
260 270 280 290 300 310
pF1KE3 TVDPGSGTVLWTQDLGVPVMGVYTWHQDGLRQLPHLTLARDTLHFLALRWGHIRLPASGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TVDPGSGTVLWTQDLGVPVMGVYTWHQDGLRQLPHLTLARDTLHFLALRWGHIRLPASGP
220 230 240 250 260 270
320 330 340 350 360 370
pF1KE3 RDTATLFSTLDTQLLMTLYVGKDETGFYVSKALVHTGVALVPRGLTLAPADGPTTDEVTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RDTATLFSTLDTQLLMTLYVGKDETGFYVSKALVHTGVALVPRGLTLAPADGPTTDEVTL
280 290 300 310 320 330
380 390 400 410 420 430
pF1KE3 QVSGEREGSPSTAVRYPSGSVALPSQWLLIGHHELPPVLHTTMLRVHPTLGSGTAETRPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QVSGEREGSPSTAVRYPSGSVALPSQWLLIGHHELPPVLHTTMLRVHPTLGSGTAETRPP
340 350 360 370 380 390
440 450 460 470 480 490
pF1KE3 ENTQAPAFFLELLSLSREKLWDSELHPEEKTPDSYLGLGPQDLLAASLTAVLLGGWILFV
:::::::::::
NP_001 ENTQAPAFFLE-------------------------------------------------
400
500 510 520 530 540 550
pF1KE3 MRQQQPQVVEKQQETPLAPADFAHISQDAQSLHSGASRRSQKRLQSPSKQAQPLDDPEAE
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ---QQPQVVEKQQETPLAPADFAHISQDAQSLHSGASRRSQKRLQSPSKQAQPLDDPEAE
410 420 430 440 450
560 570 580 590 600 610
pF1KE3 QLTVVGKISFNPKDVLGRGAGGTFVFRGQFEGRAVAVKRLLRECFGLVRREVQLLQESDR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QLTVVGKISFNPKDVLGRGAGGTFVFRGQFEGRAVAVKRLLRECFGLVRREVQLLQESDR
460 470 480 490 500 510
620 630 640 650 660 670
pF1KE3 HPNVLRYFCTERGPQFHYIALELCRASLQEYVENPDLDRGGLEPEVVLQQLMSGLAHLHS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HPNVLRYFCTERGPQFHYIALELCRASLQEYVENPDLDRGGLEPEVVLQQLMSGLAHLHS
520 530 540 550 560 570
680 690 700 710 720 730
pF1KE3 LHIVHRDLKPGNILITGPDSQGLGRVVLSDFGLCKKLPAGRCSFSLHSGIPGTEGWMAPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LHIVHRDLKPGNILITGPDSQGLGRVVLSDFGLCKKLPAGRCSFSLHSGIPGTEGWMAPE
580 590 600 610 620 630
740 750 760 770 780 790
pF1KE3 LLQLLPPDSPTSAVDIFSAGCVFYYVLSGGSHPFGDSLYRQANILTGAPCLAHLEEEVHD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLQLLPPDSPTSAVDIFSAGCVFYYVLSGGSHPFGDSLYRQANILTGAPCLAHLEEEVHD
640 650 660 670 680 690
800 810 820 830 840 850
pF1KE3 KVVARDLVGAMLSPLPQPRPSAPQVLAHPFFWSRAKQLQFFQDVSDWLEKESEQEPLVRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KVVARDLVGAMLSPLPQPRPSAPQVLAHPFFWSRAKQLQFFQDVSDWLEKESEQEPLVRA
700 710 720 730 740 750
860 870 880 890 900 910
pF1KE3 LEAGGCAVVRDNWHEHISMPLQTDLRKFRSYKGTSVRDLLRAVRNKKHHYRELPVEVRQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LEAGGCAVVRDNWHEHISMPLQTDLRKFRSYKGTSVRDLLRAVRNKKHHYRELPVEVRQA
760 770 780 790 800 810
920 930 940 950 960 970
pF1KE3 LGQVPDGFVQYFTNRFPRLLLHTHRAMRSCASESLFLPYYPPDSEARRPCPGATGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LGQVPDGFVQYFTNRFPRLLLHTHRAMRSCASESLFLPYYPPDSEARRPCPGATGR
820 830 840 850 860 870
>>XP_011544015 (OMIM: 604034) PREDICTED: serine/threonin (555 aa)
initn: 3056 init1: 3056 opt: 3056 Z-score: 1154.1 bits: 224.2 E(85289): 1.5e-57
Smith-Waterman score: 3056; 100.0% identity (100.0% similar) in 453 aa overlap (49-501:1-453)
20 30 40 50 60 70
pF1KE3 GAEPSPGRAGTERSLGGTQGPGQPCSCPGAMASAVRGSRPWPRLGLQLQFAALLLGTLSP
::::::::::::::::::::::::::::::
XP_011 MASAVRGSRPWPRLGLQLQFAALLLGTLSP
10 20 30
80 90 100 110 120 130
pF1KE3 QVHTLRPENLLLVSTLDGSLHALSKQTGDLKWTLRDDPVIEGPMYVTEMAFLSDPADGSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QVHTLRPENLLLVSTLDGSLHALSKQTGDLKWTLRDDPVIEGPMYVTEMAFLSDPADGSL
40 50 60 70 80 90
140 150 160 170 180 190
pF1KE3 YILGTQKQQGLMKLPFTIPELVHASPCRSSDGVFYTGRKQDAWFVVDPESGETQMTLTTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YILGTQKQQGLMKLPFTIPELVHASPCRSSDGVFYTGRKQDAWFVVDPESGETQMTLTTE
100 110 120 130 140 150
200 210 220 230 240 250
pF1KE3 GPSTPRLYIGRTQYTVTMHDPRAPALRWNTTYRRYSAPPMDGSPGKYMSHLASCGMGLLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GPSTPRLYIGRTQYTVTMHDPRAPALRWNTTYRRYSAPPMDGSPGKYMSHLASCGMGLLL
160 170 180 190 200 210
260 270 280 290 300 310
pF1KE3 TVDPGSGTVLWTQDLGVPVMGVYTWHQDGLRQLPHLTLARDTLHFLALRWGHIRLPASGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TVDPGSGTVLWTQDLGVPVMGVYTWHQDGLRQLPHLTLARDTLHFLALRWGHIRLPASGP
220 230 240 250 260 270
320 330 340 350 360 370
pF1KE3 RDTATLFSTLDTQLLMTLYVGKDETGFYVSKALVHTGVALVPRGLTLAPADGPTTDEVTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RDTATLFSTLDTQLLMTLYVGKDETGFYVSKALVHTGVALVPRGLTLAPADGPTTDEVTL
280 290 300 310 320 330
380 390 400 410 420 430
pF1KE3 QVSGEREGSPSTAVRYPSGSVALPSQWLLIGHHELPPVLHTTMLRVHPTLGSGTAETRPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QVSGEREGSPSTAVRYPSGSVALPSQWLLIGHHELPPVLHTTMLRVHPTLGSGTAETRPP
340 350 360 370 380 390
440 450 460 470 480 490
pF1KE3 ENTQAPAFFLELLSLSREKLWDSELHPEEKTPDSYLGLGPQDLLAASLTAVLLGGWILFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ENTQAPAFFLELLSLSREKLWDSELHPEEKTPDSYLGLGPQDLLAASLTAVLLGGWILFV
400 410 420 430 440 450
500 510 520 530 540 550
pF1KE3 MRQQQPQVVEKQQETPLAPADFAHISQDAQSLHSGASRRSQKRLQSPSKQAQPLDDPEAE
:::
XP_011 MRQLPRPLRSCSVSSCSLVRPSQSQILGPSRGRAWPGQSSLRLSCYSNSRRWWRSSRRPP
460 470 480 490 500 510
>>XP_011544014 (OMIM: 604034) PREDICTED: serine/threonin (557 aa)
initn: 3056 init1: 3056 opt: 3056 Z-score: 1154.1 bits: 224.2 E(85289): 1.5e-57
Smith-Waterman score: 3056; 100.0% identity (100.0% similar) in 453 aa overlap (49-501:1-453)
20 30 40 50 60 70
pF1KE3 GAEPSPGRAGTERSLGGTQGPGQPCSCPGAMASAVRGSRPWPRLGLQLQFAALLLGTLSP
::::::::::::::::::::::::::::::
XP_011 MASAVRGSRPWPRLGLQLQFAALLLGTLSP
10 20 30
80 90 100 110 120 130
pF1KE3 QVHTLRPENLLLVSTLDGSLHALSKQTGDLKWTLRDDPVIEGPMYVTEMAFLSDPADGSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QVHTLRPENLLLVSTLDGSLHALSKQTGDLKWTLRDDPVIEGPMYVTEMAFLSDPADGSL
40 50 60 70 80 90
140 150 160 170 180 190
pF1KE3 YILGTQKQQGLMKLPFTIPELVHASPCRSSDGVFYTGRKQDAWFVVDPESGETQMTLTTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YILGTQKQQGLMKLPFTIPELVHASPCRSSDGVFYTGRKQDAWFVVDPESGETQMTLTTE
100 110 120 130 140 150
200 210 220 230 240 250
pF1KE3 GPSTPRLYIGRTQYTVTMHDPRAPALRWNTTYRRYSAPPMDGSPGKYMSHLASCGMGLLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GPSTPRLYIGRTQYTVTMHDPRAPALRWNTTYRRYSAPPMDGSPGKYMSHLASCGMGLLL
160 170 180 190 200 210
260 270 280 290 300 310
pF1KE3 TVDPGSGTVLWTQDLGVPVMGVYTWHQDGLRQLPHLTLARDTLHFLALRWGHIRLPASGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TVDPGSGTVLWTQDLGVPVMGVYTWHQDGLRQLPHLTLARDTLHFLALRWGHIRLPASGP
220 230 240 250 260 270
320 330 340 350 360 370
pF1KE3 RDTATLFSTLDTQLLMTLYVGKDETGFYVSKALVHTGVALVPRGLTLAPADGPTTDEVTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RDTATLFSTLDTQLLMTLYVGKDETGFYVSKALVHTGVALVPRGLTLAPADGPTTDEVTL
280 290 300 310 320 330
380 390 400 410 420 430
pF1KE3 QVSGEREGSPSTAVRYPSGSVALPSQWLLIGHHELPPVLHTTMLRVHPTLGSGTAETRPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QVSGEREGSPSTAVRYPSGSVALPSQWLLIGHHELPPVLHTTMLRVHPTLGSGTAETRPP
340 350 360 370 380 390
440 450 460 470 480 490
pF1KE3 ENTQAPAFFLELLSLSREKLWDSELHPEEKTPDSYLGLGPQDLLAASLTAVLLGGWILFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ENTQAPAFFLELLSLSREKLWDSELHPEEKTPDSYLGLGPQDLLAASLTAVLLGGWILFV
400 410 420 430 440 450
500 510 520 530 540 550
pF1KE3 MRQQQPQVVEKQQETPLAPADFAHISQDAQSLHSGASRRSQKRLQSPSKQAQPLDDPEAE
:::
XP_011 MRQLPRPLRSCSVSSCSLVRPSQSQILGPSRGRAWPGQSSLRLSCYSNSRRWWRSSRRPP
460 470 480 490 500 510
>>NP_001424 (OMIM: 604033) serine/threonine-protein kina (977 aa)
initn: 2895 init1: 1791 opt: 1816 Z-score: 697.0 bits: 140.4 E(85289): 4.4e-32
Smith-Waterman score: 2907; 50.3% identity (71.3% similar) in 974 aa overlap (58-963:2-969)
30 40 50 60 70 80
pF1KE3 GTERSLGGTQGPGQPCSCPGAMASAVRGSRPWPRLGLQLQFAALLLGTLSPQVHTLRPEN
: :: : : . :: .. . ::.
NP_001 MPARRLLLLLTLLLPGLGIFGSTSTVTLPET
10 20 30
90 100 110 120 130 140
pF1KE3 LLLVSTLDGSLHALSKQTGDLKWTLRDDPVIEGPMYVTEMAFLSDPADGSLYILGTQKQQ
::.::::::::::.::.::..::::..:::.. : .: : ::: :: ::::: ::.....
NP_001 LLFVSTLDGSLHAVSKRTGSIKWTLKEDPVLQVPTHVEEPAFLPDPNDGSLYTLGSKNNE
40 50 60 70 80 90
150 160 170 180 190 200
pF1KE3 GLMKLPFTIPELVHASPCRSSDGVFYTGRKQDAWFVVDPESGETQMTLTTE-----GPST
:: ::::::::::.:::::::::..: :.::: :.:.: .:: :.::.. :::
NP_001 GLTKLPFTIPELVQASPCRSSDGILYMGKKQDIWYVIDLLTGEKQQTLSSAFADSLCPST
100 110 120 130 140 150
210 220 230 240 250 260
pF1KE3 PRLYIGRTQYTVTMHDPRAPALRWNTTYRRYSAP-PMDGSPGKYMSHLASCGMGLLLTVD
::.:::.::.::.: .. ::::.:: :.: : : : :::..: : ::..:::
NP_001 SLLYLGRTEYTITMYDTKTRELRWNATYFDYAASLPEDDVDYK-MSHFVSNGDGLVVTVD
160 170 180 190 200 210
270 280 290 300 310
pF1KE3 PGSGTVLWTQDLGVPVMGVYTWHQDGLRQLPHLTLARDTLHFLALRWGHI----RLPASG
:: ::: :. . ::.. :.:...:::.. :...: .::..:.. :.. .
NP_001 SESGDVLWIQNYASPVVAFYVWQREGLRKVMHINVAVETLRYLTFMSGEVGRITKWKYPF
220 230 240 250 260 270
320 330 340 350 360 370
pF1KE3 PRDTATLFSTLDTQLLMTLYVGKDETGFYVSKALVHTGVALVPRGLTLAPADGPTTDEVT
:..: . ..: :::::: :..:.: ..:: :::.:::: :: .:: :: ::
NP_001 PKETEA-----KSKLTPTLYVGKYSTSLYASPSMVHEGVAVVPRGSTLPLLEGPQTDGVT
280 290 300 310 320
380 390 400 410 420 430
pF1KE3 LQVSGEREGSPSTAVRYPSGSVA------LPSQWLLIGHHELPPVLHTTMLRVHPTLGSG
. .:: .::: :.. : . : . :::::::: : : ::. :.
NP_001 IGDKGECVITPSTDVKFDPGLKSKNKLNYLRNYWLLIGHHETPLSASTKMLERFPNNLPK
330 340 350 360 370 380
440 450 460 470 480
pF1KE3 TAETRPPENTQAPAF--FLELLSLSREKL-----WDSELHPEEKT--PDSYLGLGPQDLL
:. : ... .: ..:.. . :. : : .: . :.. . .:.
NP_001 HRENVIPADSEKKSFEEVINLVDQTSENAPTTVSRDVEEKPAHAPARPEAPVDSMLKDMA
390 400 410 420 430 440
490 500 510 520
pF1KE3 AASLTAVLLGGWILFV------MRQQQP-------------QVVEKQQET-PL-APADFA
. :.. :: ::. :. :.::: :....::. :. :.: :
NP_001 TIILSTFLLIGWVAFIITYPLSMHQQQQLQHQQFQKELEKIQLLQQQQQQLPFHPPGDTA
450 460 470 480 490 500
530 540 550 560
pF1KE3 HISQ--DAQ---SLHSGAS------RRSQKRLQSPSKQAQPLDDPEAEQ--------LTV
. .. :.. : ::.: : :.. : : :. .. ..: :: ...
NP_001 QDGELLDTSGPYSESSGTSSPSTSPRASNHSLCSGSSASKAGSSPSLEQDDGDEETSVVI
510 520 530 540 550 560
570 580 590 600 610 620
pF1KE3 VGKISFNPKDVLGRGAGGTFVFRGQFEGRAVAVKRLLRECFGLVRREVQLLQESDRHPNV
:::::: ::::::.:: ::.:.::.:..: :::::.: :::... ::::::.:::.::::
NP_001 VGKISFCPKDVLGHGAEGTIVYRGMFDNRDVAVKRILPECFSFADREVQLLRESDEHPNV
570 580 590 600 610 620
630 640 650 660 670 680
pF1KE3 LRYFCTERGPQFHYIALELCRASLQEYVENPDLDRGGLEPEVVLQQLMSGLAHLHSLHIV
.::::::. ::.:::.::: :.::::::. :. . :::: ..::: :::::::::.::
NP_001 IRYFCTEKDRQFQYIAIELCAATLQEYVEQKDFAHLGLEPITLLQQTTSGLAHLHSLNIV
630 640 650 660 670 680
690 700 710 720 730 740
pF1KE3 HRDLKPGNILITGPDSQGLGRVVLSDFGLCKKLPAGRCSFSLHSGIPGTEGWMAPELLQL
:::::: ::::. :...: ....::::::::: .:: ::: .::.::::::.:::.:.
NP_001 HRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLSE
690 700 710 720 730 740
750 760 770 780 790 800
pF1KE3 LPPDSPTSAVDIFSAGCVFYYVLSGGSHPFGDSLYRQANILTGAPCLAHLEEEVHDKVVA
..:: .:::::::::::::.: :::::: :: :::::: :: : :. : :. :.:
NP_001 DCKENPTYTVDIFSAGCVFYYVISEGSHPFGKSLQRQANILLGACSLDCLHPEKHEDVIA
750 760 770 780 790 800
810 820 830 840 850 860
pF1KE3 RDLVGAMLSPLPQPRPSAPQVLAHPFFWSRAKQLQFFQDVSDWLEKESEQEPLVRALEAG
:.:. :.. :: :::: .:: :::::: ::::::::::: .:::: . :.:. :: :
NP_001 RELIEKMIAMDPQKRPSAKHVLKHPFFWSLEKQLQFFQDVSDRIEKESLDGPIVKQLERG
810 820 830 840 850 860
870 880 890 900 910 920
pF1KE3 GCAVVRDNWHEHISMPLQTDLRKFRSYKGTSVRDLLRAVRNKKHHYRELPVEVRQALGQV
: :::. .:.:.:..::::::::::.::: ::::::::.:::::::::::.:::..::..
NP_001 GRAVVKMDWRENITVPLQTDLRKFRTYKGGSVRDLLRAMRNKKHHYRELPAEVRETLGSL
870 880 890 900 910 920
930 940 950 960 970
pF1KE3 PDGFVQYFTNRFPRLLLHTHRAMRSCASESLFLPYY---PPDSEARRPCPGATGR
:: :: :::.:::.:: ::.:::. :. : :: ::: ::. .
NP_001 PDDFVCYFTSRFPHLLAHTYRAMELCSHERLFQPYYFHEPPEPQPPVTPDAL
930 940 950 960 970
>>XP_016879837 (OMIM: 604033) PREDICTED: serine/threonin (980 aa)
initn: 2757 init1: 1791 opt: 1816 Z-score: 697.0 bits: 140.4 E(85289): 4.4e-32
Smith-Waterman score: 2741; 48.0% identity (69.0% similar) in 988 aa overlap (43-963:27-972)
20 30 40 50 60 70
pF1KE3 GLQAQPGAEPSPGRAGTERSLGGTQGPGQPCSCPGAMASAVRGSRPWPRLGLQLQFAALL
: :.. . .. . : . .. . .
XP_016 MQQGVRTLTRELASATCPAGFLVLGGCRLPSVHRDFLEQVELWELHSWKIPHGFEI
10 20 30 40 50
80 90 100 110 120 130
pF1KE3 LGTLSPQVHTLRPENLLLVSTLDGSLHALSKQTGDLKWTLRDDPVIEGPMYVTEMAFLSD
.:. : . :: ::.::.::::::::::.::.::..::::..:::.. : .: : ::: :
XP_016 FGSTS--TVTL-PETLLFVSTLDGSLHAVSKRTGSIKWTLKEDPVLQVPTHVEEPAFLPD
60 70 80 90 100 110
140 150 160 170 180 190
pF1KE3 PADGSLYILGTQKQQGLMKLPFTIPELVHASPCRSSDGVFYTGRKQDAWFVVDPESGETQ
: ::::: ::.....:: ::::::::::.:::::::::..: :.::: :.:.: .:: :
XP_016 PNDGSLYTLGSKNNEGLTKLPFTIPELVQASPCRSSDGILYMGKKQDIWYVIDLLTGEKQ
120 130 140 150 160 170
200 210 220 230 240
pF1KE3 MTLTTE-----GPSTPRLYIGRTQYTVTMHDPRAPALRWNTTYRRYSAPPMDGSPGKYMS
.::.. ::: ::.:::. ::
XP_016 QTLSSAFADSLCPSTSLLYLGRTE----------------------------------MS
180 190
250 260 270 280 290 300
pF1KE3 HLASCGMGLLLTVDPGSGTVLWTQDLGVPVMGVYTWHQDGLRQLPHLTLARDTLHFLALR
:..: : ::..::: :: ::: :. . ::.. :.:...:::.. :...: .::..:..
XP_016 HFVSNGDGLVVTVDSESGDVLWIQNYASPVVAFYVWQREGLRKVMHINVAVETLRYLTFM
200 210 220 230 240 250
310 320 330 340 350 360
pF1KE3 WGHI----RLPASGPRDTATLFSTLDTQLLMTLYVGKDETGFYVSKALVHTGVALVPRGL
:.. . :..: . ..: :::::: :..:.: ..:: :::.::::
XP_016 SGEVGRITKWKYPFPKETEA-----KSKLTPTLYVGKYSTSLYASPSMVHEGVAVVPRGS
260 270 280 290 300 310
370 380 390 400 410
pF1KE3 TLAPADGPTTDEVTLQVSGEREGSPSTAVRYPSGSVA------LPSQWLLIGHHELPPVL
:: .:: :: ::. .:: .::: :.. : . : . :::::::: :
XP_016 TLPLLEGPQTDGVTIGDKGECVITPSTDVKFDPGLKSKNKLNYLRNYWLLIGHHETPLSA
320 330 340 350 360 370
420 430 440 450 460
pF1KE3 HTTMLRVHPTLGSGTAETRPPENTQAPAF--FLELLSLSREKL-----WDSELHPEEKT-
: ::. :. :. : ... .: ..:.. . :. : : .: .
XP_016 STKMLERFPNNLPKHRENVIPADSEKKSFEEVINLVDQTSENAPTTVSRDVEEKPAHAPA
380 390 400 410 420 430
470 480 490 500
pF1KE3 -PDSYLGLGPQDLLAASLTAVLLGGWILFV------MRQQQP-------------QVVEK
:.. . .:. . :.. :: ::. :. :.::: :....
XP_016 RPEAPVDSMLKDMATIILSTFLLIGWVAFIITYPLSMHQQQQLQHQQFQKELEKIQLLQQ
440 450 460 470 480 490
510 520 530 540 550
pF1KE3 QQET-PL-APADFAHISQ--DAQ---SLHSGAS------RRSQKRLQSPSKQAQPLDDPE
::. :. :.: :. .. :.. : ::.: : :.. : : :. .. ..:
XP_016 QQQQLPFHPPGDTAQDGELLDTSGPYSESSGTSSPSTSPRASNHSLCSGSSASKAGSSPS
500 510 520 530 540 550
560 570 580 590 600
pF1KE3 AEQ--------LTVVGKISFNPKDVLGRGAGGTFVFRGQFEGRAVAVKRLLRECFGLVRR
:: ...:::::: ::::::.:: ::.:.::.:..: :::::.: :::... :
XP_016 LEQDDGDEETSVVIVGKISFCPKDVLGHGAEGTIVYRGMFDNRDVAVKRILPECFSFADR
560 570 580 590 600 610
610 620 630 640 650 660
pF1KE3 EVQLLQESDRHPNVLRYFCTERGPQFHYIALELCRASLQEYVENPDLDRGGLEPEVVLQQ
:::::.:::.::::.::::::. ::.:::.::: :.::::::. :. . :::: ..:::
XP_016 EVQLLRESDEHPNVIRYFCTEKDRQFQYIAIELCAATLQEYVEQKDFAHLGLEPITLLQQ
620 630 640 650 660 670
670 680 690 700 710 720
pF1KE3 LMSGLAHLHSLHIVHRDLKPGNILITGPDSQGLGRVVLSDFGLCKKLPAGRCSFSLHSGI
:::::::::.:::::::: ::::. :...: ....::::::::: .:: ::: .::.
XP_016 TTSGLAHLHSLNIVHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGRHSFSRRSGV
680 690 700 710 720 730
730 740 750 760 770 780
pF1KE3 PGTEGWMAPELLQLLPPDSPTSAVDIFSAGCVFYYVLSGGSHPFGDSLYRQANILTGAPC
::::::.:::.:. ..:: .:::::::::::::.: :::::: :: :::::: ::
XP_016 PGTEGWIAPEMLSEDCKENPTYTVDIFSAGCVFYYVISEGSHPFGKSLQRQANILLGACS
740 750 760 770 780 790
790 800 810 820 830 840
pF1KE3 LAHLEEEVHDKVVARDLVGAMLSPLPQPRPSAPQVLAHPFFWSRAKQLQFFQDVSDWLEK
: :. : :. :.::.:. :.. :: :::: .:: :::::: ::::::::::: .::
XP_016 LDCLHPEKHEDVIARELIEKMIAMDPQKRPSAKHVLKHPFFWSLEKQLQFFQDVSDRIEK
800 810 820 830 840 850
850 860 870 880 890 900
pF1KE3 ESEQEPLVRALEAGGCAVVRDNWHEHISMPLQTDLRKFRSYKGTSVRDLLRAVRNKKHHY
:: . :.:. :: :: :::. .:.:.:..::::::::::.::: ::::::::.:::::::
XP_016 ESLDGPIVKQLERGGRAVVKMDWRENITVPLQTDLRKFRTYKGGSVRDLLRAMRNKKHHY
860 870 880 890 900 910
910 920 930 940 950 960
pF1KE3 RELPVEVRQALGQVPDGFVQYFTNRFPRLLLHTHRAMRSCASESLFLPYY---PPDSEAR
::::.:::..::..:: :: :::.:::.:: ::.:::. :. : :: ::: ::. .
XP_016 RELPAEVRETLGSLPDDFVCYFTSRFPHLLAHTYRAMELCSHERLFQPYYFHEPPEPQPP
920 930 940 950 960 970
970
pF1KE3 RPCPGATGR
XP_016 VTPDAL
980
>>XP_016879836 (OMIM: 604033) PREDICTED: serine/threonin (1014 aa)
initn: 2888 init1: 1791 opt: 1816 Z-score: 696.8 bits: 140.4 E(85289): 4.5e-32
Smith-Waterman score: 2902; 49.5% identity (71.2% similar) in 989 aa overlap (43-963:27-1006)
20 30 40 50 60 70
pF1KE3 GLQAQPGAEPSPGRAGTERSLGGTQGPGQPCSCPGAMASAVRGSRPWPRLGLQLQFAALL
: :.. . .. . : . .. . .
XP_016 MQQGVRTLTRELASATCPAGFLVLGGCRLPSVHRDFLEQVELWELHSWKIPHGFEI
10 20 30 40 50
80 90 100 110 120 130
pF1KE3 LGTLSPQVHTLRPENLLLVSTLDGSLHALSKQTGDLKWTLRDDPVIEGPMYVTEMAFLSD
.:. : . :: ::.::.::::::::::.::.::..::::..:::.. : .: : ::: :
XP_016 FGSTS--TVTL-PETLLFVSTLDGSLHAVSKRTGSIKWTLKEDPVLQVPTHVEEPAFLPD
60 70 80 90 100 110
140 150 160 170 180 190
pF1KE3 PADGSLYILGTQKQQGLMKLPFTIPELVHASPCRSSDGVFYTGRKQDAWFVVDPESGETQ
: ::::: ::.....:: ::::::::::.:::::::::..: :.::: :.:.: .:: :
XP_016 PNDGSLYTLGSKNNEGLTKLPFTIPELVQASPCRSSDGILYMGKKQDIWYVIDLLTGEKQ
120 130 140 150 160 170
200 210 220 230 240
pF1KE3 MTLTTE-----GPSTPRLYIGRTQYTVTMHDPRAPALRWNTTYRRYSAP-PMDGSPGKYM
.::.. ::: ::.:::.::.::.: .. ::::.:: :.: : : : :
XP_016 QTLSSAFADSLCPSTSLLYLGRTEYTITMYDTKTRELRWNATYFDYAASLPEDDVDYK-M
180 190 200 210 220 230
250 260 270 280 290 300
pF1KE3 SHLASCGMGLLLTVDPGSGTVLWTQDLGVPVMGVYTWHQDGLRQLPHLTLARDTLHFLAL
::..: : ::..::: :: ::: :. . ::.. :.:...:::.. :...: .::..:..
XP_016 SHFVSNGDGLVVTVDSESGDVLWIQNYASPVVAFYVWQREGLRKVMHINVAVETLRYLTF
240 250 260 270 280 290
310 320 330 340 350 360
pF1KE3 RWGHI----RLPASGPRDTATLFSTLDTQLLMTLYVGKDETGFYVSKALVHTGVALVPRG
:.. . :..: . ..: :::::: :..:.: ..:: :::.::::
XP_016 MSGEVGRITKWKYPFPKETEA-----KSKLTPTLYVGKYSTSLYASPSMVHEGVAVVPRG
300 310 320 330 340
370 380 390 400 410
pF1KE3 LTLAPADGPTTDEVTLQVSGEREGSPSTAVRYPSGSVA------LPSQWLLIGHHELPPV
:: .:: :: ::. .:: .::: :.. : . : . :::::::: :
XP_016 STLPLLEGPQTDGVTIGDKGECVITPSTDVKFDPGLKSKNKLNYLRNYWLLIGHHETPLS
350 360 370 380 390 400
420 430 440 450 460
pF1KE3 LHTTMLRVHPTLGSGTAETRPPENTQAPAF--FLELLSLSREKL-----WDSELHPEEKT
: ::. :. :. : ... .: ..:.. . :. : : .: .
XP_016 ASTKMLERFPNNLPKHRENVIPADSEKKSFEEVINLVDQTSENAPTTVSRDVEEKPAHAP
410 420 430 440 450 460
470 480 490 500
pF1KE3 --PDSYLGLGPQDLLAASLTAVLLGGWILFV------MRQQQP-------------QVVE
:.. . .:. . :.. :: ::. :. :.::: :...
XP_016 ARPEAPVDSMLKDMATIILSTFLLIGWVAFIITYPLSMHQQQQLQHQQFQKELEKIQLLQ
470 480 490 500 510 520
510 520 530 540 550
pF1KE3 KQQET-PL-APADFAHISQ--DAQ---SLHSGAS------RRSQKRLQSPSKQAQPLDDP
.::. :. :.: :. .. :.. : ::.: : :.. : : :. .. ..:
XP_016 QQQQQLPFHPPGDTAQDGELLDTSGPYSESSGTSSPSTSPRASNHSLCSGSSASKAGSSP
530 540 550 560 570 580
560 570 580 590 600
pF1KE3 EAEQ--------LTVVGKISFNPKDVLGRGAGGTFVFRGQFEGRAVAVKRLLRECFGLVR
:: ...:::::: ::::::.:: ::.:.::.:..: :::::.: :::...
XP_016 SLEQDDGDEETSVVIVGKISFCPKDVLGHGAEGTIVYRGMFDNRDVAVKRILPECFSFAD
590 600 610 620 630 640
610 620 630 640 650 660
pF1KE3 REVQLLQESDRHPNVLRYFCTERGPQFHYIALELCRASLQEYVENPDLDRGGLEPEVVLQ
::::::.:::.::::.::::::. ::.:::.::: :.::::::. :. . :::: ..::
XP_016 REVQLLRESDEHPNVIRYFCTEKDRQFQYIAIELCAATLQEYVEQKDFAHLGLEPITLLQ
650 660 670 680 690 700
670 680 690 700 710 720
pF1KE3 QLMSGLAHLHSLHIVHRDLKPGNILITGPDSQGLGRVVLSDFGLCKKLPAGRCSFSLHSG
: :::::::::.:::::::: ::::. :...: ....::::::::: .:: ::: .::
XP_016 QTTSGLAHLHSLNIVHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGRHSFSRRSG
710 720 730 740 750 760
730 740 750 760 770 780
pF1KE3 IPGTEGWMAPELLQLLPPDSPTSAVDIFSAGCVFYYVLSGGSHPFGDSLYRQANILTGAP
.::::::.:::.:. ..:: .:::::::::::::.: :::::: :: :::::: ::
XP_016 VPGTEGWIAPEMLSEDCKENPTYTVDIFSAGCVFYYVISEGSHPFGKSLQRQANILLGAC
770 780 790 800 810 820
790 800 810 820 830 840
pF1KE3 CLAHLEEEVHDKVVARDLVGAMLSPLPQPRPSAPQVLAHPFFWSRAKQLQFFQDVSDWLE
: :. : :. :.::.:. :.. :: :::: .:: :::::: ::::::::::: .:
XP_016 SLDCLHPEKHEDVIARELIEKMIAMDPQKRPSAKHVLKHPFFWSLEKQLQFFQDVSDRIE
830 840 850 860 870 880
850 860 870 880 890 900
pF1KE3 KESEQEPLVRALEAGGCAVVRDNWHEHISMPLQTDLRKFRSYKGTSVRDLLRAVRNKKHH
::: . :.:. :: :: :::. .:.:.:..::::::::::.::: ::::::::.::::::
XP_016 KESLDGPIVKQLERGGRAVVKMDWRENITVPLQTDLRKFRTYKGGSVRDLLRAMRNKKHH
890 900 910 920 930 940
910 920 930 940 950 960
pF1KE3 YRELPVEVRQALGQVPDGFVQYFTNRFPRLLLHTHRAMRSCASESLFLPYY---PPDSEA
:::::.:::..::..:: :: :::.:::.:: ::.:::. :. : :: ::: ::. .
XP_016 YRELPAEVRETLGSLPDDFVCYFTSRFPHLLAHTYRAMELCSHERLFQPYYFHEPPEPQP
950 960 970 980 990 1000
970
pF1KE3 RRPCPGATGR
XP_016 PVTPDAL
1010
974 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 18:48:13 2016 done: Mon Nov 7 18:48:15 2016
Total Scan time: 9.720 Total Display time: 0.210
Function used was FASTA [36.3.4 Apr, 2011]