FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE3335, 974 aa 1>>>pF1KE3335 974 - 974 aa - 974 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 9.5312+/-0.00115; mu= 1.4484+/- 0.067 mean_var=385.8913+/-87.766, 0's: 0 Z-trim(111.4): 284 B-trim: 0 in 0/54 Lambda= 0.065289 statistics sampled from 12024 (12333) to 12024 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.719), E-opt: 0.2 (0.379), width: 16 Scan time: 4.080 The best scores are: opt bits E(32554) CCDS32407.2 ERN2 gene_id:10595|Hs108|chr16 ( 926) 6305 609.6 8.9e-174 CCDS76845.1 ERN2 gene_id:10595|Hs108|chr16 ( 874) 3251 321.9 3.4e-87 CCDS45762.1 ERN1 gene_id:2081|Hs108|chr17 ( 977) 1816 186.8 1.8e-46 >>CCDS32407.2 ERN2 gene_id:10595|Hs108|chr16 (926 aa) initn: 6305 init1: 6305 opt: 6305 Z-score: 3233.3 bits: 609.6 E(32554): 8.9e-174 Smith-Waterman score: 6305; 100.0% identity (100.0% similar) in 926 aa overlap (49-974:1-926) 20 30 40 50 60 70 pF1KE3 GAEPSPGRAGTERSLGGTQGPGQPCSCPGAMASAVRGSRPWPRLGLQLQFAALLLGTLSP :::::::::::::::::::::::::::::: CCDS32 MASAVRGSRPWPRLGLQLQFAALLLGTLSP 10 20 30 80 90 100 110 120 130 pF1KE3 QVHTLRPENLLLVSTLDGSLHALSKQTGDLKWTLRDDPVIEGPMYVTEMAFLSDPADGSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS32 QVHTLRPENLLLVSTLDGSLHALSKQTGDLKWTLRDDPVIEGPMYVTEMAFLSDPADGSL 40 50 60 70 80 90 140 150 160 170 180 190 pF1KE3 YILGTQKQQGLMKLPFTIPELVHASPCRSSDGVFYTGRKQDAWFVVDPESGETQMTLTTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS32 YILGTQKQQGLMKLPFTIPELVHASPCRSSDGVFYTGRKQDAWFVVDPESGETQMTLTTE 100 110 120 130 140 150 200 210 220 230 240 250 pF1KE3 GPSTPRLYIGRTQYTVTMHDPRAPALRWNTTYRRYSAPPMDGSPGKYMSHLASCGMGLLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS32 GPSTPRLYIGRTQYTVTMHDPRAPALRWNTTYRRYSAPPMDGSPGKYMSHLASCGMGLLL 160 170 180 190 200 210 260 270 280 290 300 310 pF1KE3 TVDPGSGTVLWTQDLGVPVMGVYTWHQDGLRQLPHLTLARDTLHFLALRWGHIRLPASGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS32 TVDPGSGTVLWTQDLGVPVMGVYTWHQDGLRQLPHLTLARDTLHFLALRWGHIRLPASGP 220 230 240 250 260 270 320 330 340 350 360 370 pF1KE3 RDTATLFSTLDTQLLMTLYVGKDETGFYVSKALVHTGVALVPRGLTLAPADGPTTDEVTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS32 RDTATLFSTLDTQLLMTLYVGKDETGFYVSKALVHTGVALVPRGLTLAPADGPTTDEVTL 280 290 300 310 320 330 380 390 400 410 420 430 pF1KE3 QVSGEREGSPSTAVRYPSGSVALPSQWLLIGHHELPPVLHTTMLRVHPTLGSGTAETRPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS32 QVSGEREGSPSTAVRYPSGSVALPSQWLLIGHHELPPVLHTTMLRVHPTLGSGTAETRPP 340 350 360 370 380 390 440 450 460 470 480 490 pF1KE3 ENTQAPAFFLELLSLSREKLWDSELHPEEKTPDSYLGLGPQDLLAASLTAVLLGGWILFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS32 ENTQAPAFFLELLSLSREKLWDSELHPEEKTPDSYLGLGPQDLLAASLTAVLLGGWILFV 400 410 420 430 440 450 500 510 520 530 540 550 pF1KE3 MRQQQPQVVEKQQETPLAPADFAHISQDAQSLHSGASRRSQKRLQSPSKQAQPLDDPEAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS32 MRQQQPQVVEKQQETPLAPADFAHISQDAQSLHSGASRRSQKRLQSPSKQAQPLDDPEAE 460 470 480 490 500 510 560 570 580 590 600 610 pF1KE3 QLTVVGKISFNPKDVLGRGAGGTFVFRGQFEGRAVAVKRLLRECFGLVRREVQLLQESDR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS32 QLTVVGKISFNPKDVLGRGAGGTFVFRGQFEGRAVAVKRLLRECFGLVRREVQLLQESDR 520 530 540 550 560 570 620 630 640 650 660 670 pF1KE3 HPNVLRYFCTERGPQFHYIALELCRASLQEYVENPDLDRGGLEPEVVLQQLMSGLAHLHS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS32 HPNVLRYFCTERGPQFHYIALELCRASLQEYVENPDLDRGGLEPEVVLQQLMSGLAHLHS 580 590 600 610 620 630 680 690 700 710 720 730 pF1KE3 LHIVHRDLKPGNILITGPDSQGLGRVVLSDFGLCKKLPAGRCSFSLHSGIPGTEGWMAPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS32 LHIVHRDLKPGNILITGPDSQGLGRVVLSDFGLCKKLPAGRCSFSLHSGIPGTEGWMAPE 640 650 660 670 680 690 740 750 760 770 780 790 pF1KE3 LLQLLPPDSPTSAVDIFSAGCVFYYVLSGGSHPFGDSLYRQANILTGAPCLAHLEEEVHD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS32 LLQLLPPDSPTSAVDIFSAGCVFYYVLSGGSHPFGDSLYRQANILTGAPCLAHLEEEVHD 700 710 720 730 740 750 800 810 820 830 840 850 pF1KE3 KVVARDLVGAMLSPLPQPRPSAPQVLAHPFFWSRAKQLQFFQDVSDWLEKESEQEPLVRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS32 KVVARDLVGAMLSPLPQPRPSAPQVLAHPFFWSRAKQLQFFQDVSDWLEKESEQEPLVRA 760 770 780 790 800 810 860 870 880 890 900 910 pF1KE3 LEAGGCAVVRDNWHEHISMPLQTDLRKFRSYKGTSVRDLLRAVRNKKHHYRELPVEVRQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS32 LEAGGCAVVRDNWHEHISMPLQTDLRKFRSYKGTSVRDLLRAVRNKKHHYRELPVEVRQA 820 830 840 850 860 870 920 930 940 950 960 970 pF1KE3 LGQVPDGFVQYFTNRFPRLLLHTHRAMRSCASESLFLPYYPPDSEARRPCPGATGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS32 LGQVPDGFVQYFTNRFPRLLLHTHRAMRSCASESLFLPYYPPDSEARRPCPGATGR 880 890 900 910 920 >>CCDS76845.1 ERN2 gene_id:10595|Hs108|chr16 (874 aa) initn: 3251 init1: 3251 opt: 3251 Z-score: 1678.9 bits: 321.9 E(32554): 3.4e-87 Smith-Waterman score: 5848; 94.4% identity (94.4% similar) in 926 aa overlap (49-974:1-874) 20 30 40 50 60 70 pF1KE3 GAEPSPGRAGTERSLGGTQGPGQPCSCPGAMASAVRGSRPWPRLGLQLQFAALLLGTLSP :::::::::::::::::::::::::::::: CCDS76 MASAVRGSRPWPRLGLQLQFAALLLGTLSP 10 20 30 80 90 100 110 120 130 pF1KE3 QVHTLRPENLLLVSTLDGSLHALSKQTGDLKWTLRDDPVIEGPMYVTEMAFLSDPADGSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS76 QVHTLRPENLLLVSTLDGSLHALSKQTGDLKWTLRDDPVIEGPMYVTEMAFLSDPADGSL 40 50 60 70 80 90 140 150 160 170 180 190 pF1KE3 YILGTQKQQGLMKLPFTIPELVHASPCRSSDGVFYTGRKQDAWFVVDPESGETQMTLTTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS76 YILGTQKQQGLMKLPFTIPELVHASPCRSSDGVFYTGRKQDAWFVVDPESGETQMTLTTE 100 110 120 130 140 150 200 210 220 230 240 250 pF1KE3 GPSTPRLYIGRTQYTVTMHDPRAPALRWNTTYRRYSAPPMDGSPGKYMSHLASCGMGLLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS76 GPSTPRLYIGRTQYTVTMHDPRAPALRWNTTYRRYSAPPMDGSPGKYMSHLASCGMGLLL 160 170 180 190 200 210 260 270 280 290 300 310 pF1KE3 TVDPGSGTVLWTQDLGVPVMGVYTWHQDGLRQLPHLTLARDTLHFLALRWGHIRLPASGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS76 TVDPGSGTVLWTQDLGVPVMGVYTWHQDGLRQLPHLTLARDTLHFLALRWGHIRLPASGP 220 230 240 250 260 270 320 330 340 350 360 370 pF1KE3 RDTATLFSTLDTQLLMTLYVGKDETGFYVSKALVHTGVALVPRGLTLAPADGPTTDEVTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS76 RDTATLFSTLDTQLLMTLYVGKDETGFYVSKALVHTGVALVPRGLTLAPADGPTTDEVTL 280 290 300 310 320 330 380 390 400 410 420 430 pF1KE3 QVSGEREGSPSTAVRYPSGSVALPSQWLLIGHHELPPVLHTTMLRVHPTLGSGTAETRPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS76 QVSGEREGSPSTAVRYPSGSVALPSQWLLIGHHELPPVLHTTMLRVHPTLGSGTAETRPP 340 350 360 370 380 390 440 450 460 470 480 490 pF1KE3 ENTQAPAFFLELLSLSREKLWDSELHPEEKTPDSYLGLGPQDLLAASLTAVLLGGWILFV ::::::::::: CCDS76 ENTQAPAFFLE------------------------------------------------- 400 500 510 520 530 540 550 pF1KE3 MRQQQPQVVEKQQETPLAPADFAHISQDAQSLHSGASRRSQKRLQSPSKQAQPLDDPEAE ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS76 ---QQPQVVEKQQETPLAPADFAHISQDAQSLHSGASRRSQKRLQSPSKQAQPLDDPEAE 410 420 430 440 450 560 570 580 590 600 610 pF1KE3 QLTVVGKISFNPKDVLGRGAGGTFVFRGQFEGRAVAVKRLLRECFGLVRREVQLLQESDR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS76 QLTVVGKISFNPKDVLGRGAGGTFVFRGQFEGRAVAVKRLLRECFGLVRREVQLLQESDR 460 470 480 490 500 510 620 630 640 650 660 670 pF1KE3 HPNVLRYFCTERGPQFHYIALELCRASLQEYVENPDLDRGGLEPEVVLQQLMSGLAHLHS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS76 HPNVLRYFCTERGPQFHYIALELCRASLQEYVENPDLDRGGLEPEVVLQQLMSGLAHLHS 520 530 540 550 560 570 680 690 700 710 720 730 pF1KE3 LHIVHRDLKPGNILITGPDSQGLGRVVLSDFGLCKKLPAGRCSFSLHSGIPGTEGWMAPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS76 LHIVHRDLKPGNILITGPDSQGLGRVVLSDFGLCKKLPAGRCSFSLHSGIPGTEGWMAPE 580 590 600 610 620 630 740 750 760 770 780 790 pF1KE3 LLQLLPPDSPTSAVDIFSAGCVFYYVLSGGSHPFGDSLYRQANILTGAPCLAHLEEEVHD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS76 LLQLLPPDSPTSAVDIFSAGCVFYYVLSGGSHPFGDSLYRQANILTGAPCLAHLEEEVHD 640 650 660 670 680 690 800 810 820 830 840 850 pF1KE3 KVVARDLVGAMLSPLPQPRPSAPQVLAHPFFWSRAKQLQFFQDVSDWLEKESEQEPLVRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS76 KVVARDLVGAMLSPLPQPRPSAPQVLAHPFFWSRAKQLQFFQDVSDWLEKESEQEPLVRA 700 710 720 730 740 750 860 870 880 890 900 910 pF1KE3 LEAGGCAVVRDNWHEHISMPLQTDLRKFRSYKGTSVRDLLRAVRNKKHHYRELPVEVRQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS76 LEAGGCAVVRDNWHEHISMPLQTDLRKFRSYKGTSVRDLLRAVRNKKHHYRELPVEVRQA 760 770 780 790 800 810 920 930 940 950 960 970 pF1KE3 LGQVPDGFVQYFTNRFPRLLLHTHRAMRSCASESLFLPYYPPDSEARRPCPGATGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS76 LGQVPDGFVQYFTNRFPRLLLHTHRAMRSCASESLFLPYYPPDSEARRPCPGATGR 820 830 840 850 860 870 >>CCDS45762.1 ERN1 gene_id:2081|Hs108|chr17 (977 aa) initn: 2895 init1: 1791 opt: 1816 Z-score: 947.9 bits: 186.8 E(32554): 1.8e-46 Smith-Waterman score: 2907; 50.3% identity (71.3% similar) in 974 aa overlap (58-963:2-969) 30 40 50 60 70 80 pF1KE3 GTERSLGGTQGPGQPCSCPGAMASAVRGSRPWPRLGLQLQFAALLLGTLSPQVHTLRPEN : :: : : . :: .. . ::. CCDS45 MPARRLLLLLTLLLPGLGIFGSTSTVTLPET 10 20 30 90 100 110 120 130 140 pF1KE3 LLLVSTLDGSLHALSKQTGDLKWTLRDDPVIEGPMYVTEMAFLSDPADGSLYILGTQKQQ ::.::::::::::.::.::..::::..:::.. : .: : ::: :: ::::: ::..... CCDS45 LLFVSTLDGSLHAVSKRTGSIKWTLKEDPVLQVPTHVEEPAFLPDPNDGSLYTLGSKNNE 40 50 60 70 80 90 150 160 170 180 190 200 pF1KE3 GLMKLPFTIPELVHASPCRSSDGVFYTGRKQDAWFVVDPESGETQMTLTTE-----GPST :: ::::::::::.:::::::::..: :.::: :.:.: .:: :.::.. ::: CCDS45 GLTKLPFTIPELVQASPCRSSDGILYMGKKQDIWYVIDLLTGEKQQTLSSAFADSLCPST 100 110 120 130 140 150 210 220 230 240 250 260 pF1KE3 PRLYIGRTQYTVTMHDPRAPALRWNTTYRRYSAP-PMDGSPGKYMSHLASCGMGLLLTVD ::.:::.::.::.: .. ::::.:: :.: : : : :::..: : ::..::: CCDS45 SLLYLGRTEYTITMYDTKTRELRWNATYFDYAASLPEDDVDYK-MSHFVSNGDGLVVTVD 160 170 180 190 200 210 270 280 290 300 310 pF1KE3 PGSGTVLWTQDLGVPVMGVYTWHQDGLRQLPHLTLARDTLHFLALRWGHI----RLPASG :: ::: :. . ::.. :.:...:::.. :...: .::..:.. :.. . CCDS45 SESGDVLWIQNYASPVVAFYVWQREGLRKVMHINVAVETLRYLTFMSGEVGRITKWKYPF 220 230 240 250 260 270 320 330 340 350 360 370 pF1KE3 PRDTATLFSTLDTQLLMTLYVGKDETGFYVSKALVHTGVALVPRGLTLAPADGPTTDEVT :..: . ..: :::::: :..:.: ..:: :::.:::: :: .:: :: :: CCDS45 PKETEA-----KSKLTPTLYVGKYSTSLYASPSMVHEGVAVVPRGSTLPLLEGPQTDGVT 280 290 300 310 320 380 390 400 410 420 430 pF1KE3 LQVSGEREGSPSTAVRYPSGSVA------LPSQWLLIGHHELPPVLHTTMLRVHPTLGSG . .:: .::: :.. : . : . :::::::: : : ::. :. CCDS45 IGDKGECVITPSTDVKFDPGLKSKNKLNYLRNYWLLIGHHETPLSASTKMLERFPNNLPK 330 340 350 360 370 380 440 450 460 470 480 pF1KE3 TAETRPPENTQAPAF--FLELLSLSREKL-----WDSELHPEEKT--PDSYLGLGPQDLL :. : ... .: ..:.. . :. : : .: . :.. . .:. CCDS45 HRENVIPADSEKKSFEEVINLVDQTSENAPTTVSRDVEEKPAHAPARPEAPVDSMLKDMA 390 400 410 420 430 440 490 500 510 520 pF1KE3 AASLTAVLLGGWILFV------MRQQQP-------------QVVEKQQET-PL-APADFA . :.. :: ::. :. :.::: :....::. :. :.: : CCDS45 TIILSTFLLIGWVAFIITYPLSMHQQQQLQHQQFQKELEKIQLLQQQQQQLPFHPPGDTA 450 460 470 480 490 500 530 540 550 560 pF1KE3 HISQ--DAQ---SLHSGAS------RRSQKRLQSPSKQAQPLDDPEAEQ--------LTV . .. :.. : ::.: : :.. : : :. .. ..: :: ... CCDS45 QDGELLDTSGPYSESSGTSSPSTSPRASNHSLCSGSSASKAGSSPSLEQDDGDEETSVVI 510 520 530 540 550 560 570 580 590 600 610 620 pF1KE3 VGKISFNPKDVLGRGAGGTFVFRGQFEGRAVAVKRLLRECFGLVRREVQLLQESDRHPNV :::::: ::::::.:: ::.:.::.:..: :::::.: :::... ::::::.:::.:::: CCDS45 VGKISFCPKDVLGHGAEGTIVYRGMFDNRDVAVKRILPECFSFADREVQLLRESDEHPNV 570 580 590 600 610 620 630 640 650 660 670 680 pF1KE3 LRYFCTERGPQFHYIALELCRASLQEYVENPDLDRGGLEPEVVLQQLMSGLAHLHSLHIV .::::::. ::.:::.::: :.::::::. :. . :::: ..::: :::::::::.:: CCDS45 IRYFCTEKDRQFQYIAIELCAATLQEYVEQKDFAHLGLEPITLLQQTTSGLAHLHSLNIV 630 640 650 660 670 680 690 700 710 720 730 740 pF1KE3 HRDLKPGNILITGPDSQGLGRVVLSDFGLCKKLPAGRCSFSLHSGIPGTEGWMAPELLQL :::::: ::::. :...: ....::::::::: .:: ::: .::.::::::.:::.:. CCDS45 HRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLSE 690 700 710 720 730 740 750 760 770 780 790 800 pF1KE3 LPPDSPTSAVDIFSAGCVFYYVLSGGSHPFGDSLYRQANILTGAPCLAHLEEEVHDKVVA ..:: .:::::::::::::.: :::::: :: :::::: :: : :. : :. :.: CCDS45 DCKENPTYTVDIFSAGCVFYYVISEGSHPFGKSLQRQANILLGACSLDCLHPEKHEDVIA 750 760 770 780 790 800 810 820 830 840 850 860 pF1KE3 RDLVGAMLSPLPQPRPSAPQVLAHPFFWSRAKQLQFFQDVSDWLEKESEQEPLVRALEAG :.:. :.. :: :::: .:: :::::: ::::::::::: .:::: . :.:. :: : CCDS45 RELIEKMIAMDPQKRPSAKHVLKHPFFWSLEKQLQFFQDVSDRIEKESLDGPIVKQLERG 810 820 830 840 850 860 870 880 890 900 910 920 pF1KE3 GCAVVRDNWHEHISMPLQTDLRKFRSYKGTSVRDLLRAVRNKKHHYRELPVEVRQALGQV : :::. .:.:.:..::::::::::.::: ::::::::.:::::::::::.:::..::.. CCDS45 GRAVVKMDWRENITVPLQTDLRKFRTYKGGSVRDLLRAMRNKKHHYRELPAEVRETLGSL 870 880 890 900 910 920 930 940 950 960 970 pF1KE3 PDGFVQYFTNRFPRLLLHTHRAMRSCASESLFLPYY---PPDSEARRPCPGATGR :: :: :::.:::.:: ::.:::. :. : :: ::: ::. . CCDS45 PDDFVCYFTSRFPHLLAHTYRAMELCSHERLFQPYYFHEPPEPQPPVTPDAL 930 940 950 960 970 974 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 18:48:13 2016 done: Mon Nov 7 18:48:13 2016 Total Scan time: 4.080 Total Display time: 0.060 Function used was FASTA [36.3.4 Apr, 2011]