FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE6486, 584 aa 1>>>pF1KE6486 584 - 584 aa - 584 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.1925+/-0.000431; mu= 19.1382+/- 0.026 mean_var=68.6510+/-14.257, 0's: 0 Z-trim(110.9): 57 B-trim: 11 in 1/53 Lambda= 0.154793 statistics sampled from 19271 (19325) to 19271 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.577), E-opt: 0.2 (0.227), width: 16 Scan time: 9.260 The best scores are: opt bits E(85289) XP_011537051 (OMIM: 609841) PREDICTED: sodium/pota ( 584) 3888 878.0 0 NP_079235 (OMIM: 609841) sodium/potassium/calcium ( 584) 3888 878.0 0 XP_016875467 (OMIM: 609841) PREDICTED: sodium/pota ( 422) 2824 640.3 3.9e-183 XP_011537054 (OMIM: 609841) PREDICTED: sodium/pota ( 389) 2579 585.5 1.1e-166 XP_006719670 (OMIM: 609841) PREDICTED: sodium/pota ( 389) 2579 585.5 1.1e-166 NP_001317395 (OMIM: 609841) sodium/potassium/calci ( 528) 2345 533.3 7.3e-151 NP_065740 (OMIM: 609839) sodium/potassium/calcium ( 644) 289 74.3 1.4e-12 XP_011534743 (OMIM: 210750,609840,615887) PREDICTE ( 316) 275 70.9 7e-12 XP_011534744 (OMIM: 210750,609840,615887) PREDICTE ( 316) 275 70.9 7e-12 XP_011534742 (OMIM: 210750,609840,615887) PREDICTE ( 372) 275 71.0 8e-12 NP_705934 (OMIM: 210750,609840,615887) sodium/pota ( 558) 275 71.1 1.1e-11 NP_705933 (OMIM: 210750,609840,615887) sodium/pota ( 603) 275 71.1 1.2e-11 NP_705932 (OMIM: 210750,609840,615887) sodium/pota ( 622) 275 71.1 1.2e-11 XP_011534739 (OMIM: 210750,609840,615887) PREDICTE ( 650) 275 71.1 1.2e-11 XP_011534738 (OMIM: 210750,609840,615887) PREDICTE ( 669) 275 71.1 1.3e-11 XP_011520528 (OMIM: 603617,613830) PREDICTED: sodi ( 688) 272 70.5 2.1e-11 XP_005254838 (OMIM: 603617,613830) PREDICTED: sodi ( 717) 272 70.5 2.1e-11 XP_016878214 (OMIM: 603617,613830) PREDICTED: sodi ( 966) 272 70.6 2.7e-11 NP_001241669 (OMIM: 603617,613830) sodium/potassiu ( 426) 251 65.7 3.6e-10 NP_995322 (OMIM: 113750,609802) sodium/potassium/c ( 500) 251 65.7 4.1e-10 XP_006720831 (OMIM: 603617,613830) PREDICTED: sodi ( 985) 251 65.9 7.2e-10 NP_001287961 (OMIM: 603617,613830) sodium/potassiu (1081) 251 65.9 7.7e-10 XP_011520522 (OMIM: 603617,613830) PREDICTED: sodi (1081) 251 65.9 7.7e-10 XP_005254835 (OMIM: 603617,613830) PREDICTED: sodi (1099) 251 65.9 7.8e-10 XP_011520521 (OMIM: 603617,613830) PREDICTED: sodi (1099) 251 65.9 7.8e-10 NP_004718 (OMIM: 603617,613830) sodium/potassium/c (1099) 251 65.9 7.8e-10 XP_016870082 (OMIM: 609838) PREDICTED: sodium/pota ( 644) 245 64.4 1.3e-09 XP_006716813 (OMIM: 609838) PREDICTED: sodium/pota ( 644) 245 64.4 1.3e-09 NP_001180217 (OMIM: 609838) sodium/potassium/calci ( 644) 245 64.4 1.3e-09 NP_065077 (OMIM: 609838) sodium/potassium/calcium ( 661) 245 64.4 1.3e-09 XP_005251483 (OMIM: 609838) PREDICTED: sodium/pota ( 661) 245 64.4 1.3e-09 XP_005251482 (OMIM: 609838) PREDICTED: sodium/pota ( 661) 245 64.4 1.3e-09 XP_016870081 (OMIM: 609838) PREDICTED: sodium/pota ( 661) 245 64.4 1.3e-09 NP_001287960 (OMIM: 603617,613830) sodium/potassiu (1069) 235 62.3 9.1e-09 XP_011520523 (OMIM: 603617,613830) PREDICTED: sodi (1069) 235 62.3 9.1e-09 XP_011534741 (OMIM: 210750,609840,615887) PREDICTE ( 626) 221 59.1 5.2e-08 XP_011534740 (OMIM: 210750,609840,615887) PREDICTE ( 645) 221 59.1 5.3e-08 NP_001287962 (OMIM: 603617,613830) sodium/potassiu (1012) 189 52.1 1.1e-05 XP_011520524 (OMIM: 603617,613830) PREDICTED: sodi (1030) 189 52.1 1.1e-05 XP_016878213 (OMIM: 603617,613830) PREDICTED: sodi (1049) 180 50.1 4.5e-05 XP_016877569 (OMIM: 113750,609802) PREDICTED: sodi ( 314) 147 42.3 0.0028 XP_016877568 (OMIM: 113750,609802) PREDICTED: sodi ( 314) 147 42.3 0.0028 >>XP_011537051 (OMIM: 609841) PREDICTED: sodium/potassiu (584 aa) initn: 3888 init1: 3888 opt: 3888 Z-score: 4691.0 bits: 878.0 E(85289): 0 Smith-Waterman score: 3888; 100.0% identity (100.0% similar) in 584 aa overlap (1-584:1-584) 10 20 30 40 50 60 pF1KE6 MAGRRLNLRWALSVLCVLLMAETVSGTRGSSTGAHISPQFPASGVNQTPVVDCRKVCGLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MAGRRLNLRWALSVLCVLLMAETVSGTRGSSTGAHISPQFPASGVNQTPVVDCRKVCGLN 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 VSDRCDFIRTNPDCHSDGGYLDYLEGIFCHFPPSLLPLAVTLYVSWLLYLFLILGVTAAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VSDRCDFIRTNPDCHSDGGYLDYLEGIFCHFPPSLLPLAVTLYVSWLLYLFLILGVTAAK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 FFCPNLSAISTTLKLSHNVAGVTFLAFGNGAPDIFSALVAFSDPHTAGLALGALFGAGVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FFCPNLSAISTTLKLSHNVAGVTFLAFGNGAPDIFSALVAFSDPHTAGLALGALFGAGVL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 VTTVVAGGITILHPFMAASRPFFRDIVFYMVAVFLTFLMLFRGRVTLAWALGYLGLYVFY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VTTVVAGGITILHPFMAASRPFFRDIVFYMVAVFLTFLMLFRGRVTLAWALGYLGLYVFY 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE6 VVTVILCTWIYQRQRRGSLFCPMPVTPEILSDSEEDRVSSNTNSYDYGDEYRPLFFYQET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VVTVILCTWIYQRQRRGSLFCPMPVTPEILSDSEEDRVSSNTNSYDYGDEYRPLFFYQET 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE6 TAQILVRALNPLDYMKWRRKSAYWKALKVFKLPVEFLLLLTVPVVDPDKDDQNWKRPLNC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TAQILVRALNPLDYMKWRRKSAYWKALKVFKLPVEFLLLLTVPVVDPDKDDQNWKRPLNC 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE6 LHLVISPLVVVLTLQSGTYGVYEIGGLVPVWVVVVIAGTALASVTFFATSDSQPPRLHWL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LHLVISPLVVVLTLQSGTYGVYEIGGLVPVWVVVVIAGTALASVTFFATSDSQPPRLHWL 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE6 FAFLGFLTSALWINAAATEVVNILRSLGVVFRLSNTVLGLTLLAWGNSIGDAFSDFTLAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FAFLGFLTSALWINAAATEVVNILRSLGVVFRLSNTVLGLTLLAWGNSIGDAFSDFTLAR 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE6 QGYPRMAFSACFGGIIFNILVGVGLGCLLQISRSHTEVKLEPDGLLVWVLAGALGLSLVF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QGYPRMAFSACFGGIIFNILVGVGLGCLLQISRSHTEVKLEPDGLLVWVLAGALGLSLVF 490 500 510 520 530 540 550 560 570 580 pF1KE6 SLVSVPLQCFQLSRVYGFCLLLFYLNFLVVALLTEFGVIHLKSM :::::::::::::::::::::::::::::::::::::::::::: XP_011 SLVSVPLQCFQLSRVYGFCLLLFYLNFLVVALLTEFGVIHLKSM 550 560 570 580 >>NP_079235 (OMIM: 609841) sodium/potassium/calcium exch (584 aa) initn: 3888 init1: 3888 opt: 3888 Z-score: 4691.0 bits: 878.0 E(85289): 0 Smith-Waterman score: 3888; 100.0% identity (100.0% similar) in 584 aa overlap (1-584:1-584) 10 20 30 40 50 60 pF1KE6 MAGRRLNLRWALSVLCVLLMAETVSGTRGSSTGAHISPQFPASGVNQTPVVDCRKVCGLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 MAGRRLNLRWALSVLCVLLMAETVSGTRGSSTGAHISPQFPASGVNQTPVVDCRKVCGLN 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 VSDRCDFIRTNPDCHSDGGYLDYLEGIFCHFPPSLLPLAVTLYVSWLLYLFLILGVTAAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 VSDRCDFIRTNPDCHSDGGYLDYLEGIFCHFPPSLLPLAVTLYVSWLLYLFLILGVTAAK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 FFCPNLSAISTTLKLSHNVAGVTFLAFGNGAPDIFSALVAFSDPHTAGLALGALFGAGVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 FFCPNLSAISTTLKLSHNVAGVTFLAFGNGAPDIFSALVAFSDPHTAGLALGALFGAGVL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 VTTVVAGGITILHPFMAASRPFFRDIVFYMVAVFLTFLMLFRGRVTLAWALGYLGLYVFY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 VTTVVAGGITILHPFMAASRPFFRDIVFYMVAVFLTFLMLFRGRVTLAWALGYLGLYVFY 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE6 VVTVILCTWIYQRQRRGSLFCPMPVTPEILSDSEEDRVSSNTNSYDYGDEYRPLFFYQET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 VVTVILCTWIYQRQRRGSLFCPMPVTPEILSDSEEDRVSSNTNSYDYGDEYRPLFFYQET 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE6 TAQILVRALNPLDYMKWRRKSAYWKALKVFKLPVEFLLLLTVPVVDPDKDDQNWKRPLNC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 TAQILVRALNPLDYMKWRRKSAYWKALKVFKLPVEFLLLLTVPVVDPDKDDQNWKRPLNC 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE6 LHLVISPLVVVLTLQSGTYGVYEIGGLVPVWVVVVIAGTALASVTFFATSDSQPPRLHWL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 LHLVISPLVVVLTLQSGTYGVYEIGGLVPVWVVVVIAGTALASVTFFATSDSQPPRLHWL 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE6 FAFLGFLTSALWINAAATEVVNILRSLGVVFRLSNTVLGLTLLAWGNSIGDAFSDFTLAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 FAFLGFLTSALWINAAATEVVNILRSLGVVFRLSNTVLGLTLLAWGNSIGDAFSDFTLAR 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE6 QGYPRMAFSACFGGIIFNILVGVGLGCLLQISRSHTEVKLEPDGLLVWVLAGALGLSLVF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 QGYPRMAFSACFGGIIFNILVGVGLGCLLQISRSHTEVKLEPDGLLVWVLAGALGLSLVF 490 500 510 520 530 540 550 560 570 580 pF1KE6 SLVSVPLQCFQLSRVYGFCLLLFYLNFLVVALLTEFGVIHLKSM :::::::::::::::::::::::::::::::::::::::::::: NP_079 SLVSVPLQCFQLSRVYGFCLLLFYLNFLVVALLTEFGVIHLKSM 550 560 570 580 >>XP_016875467 (OMIM: 609841) PREDICTED: sodium/potassiu (422 aa) initn: 2824 init1: 2824 opt: 2824 Z-score: 3408.9 bits: 640.3 E(85289): 3.9e-183 Smith-Waterman score: 2824; 99.8% identity (100.0% similar) in 420 aa overlap (1-420:1-420) 10 20 30 40 50 60 pF1KE6 MAGRRLNLRWALSVLCVLLMAETVSGTRGSSTGAHISPQFPASGVNQTPVVDCRKVCGLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MAGRRLNLRWALSVLCVLLMAETVSGTRGSSTGAHISPQFPASGVNQTPVVDCRKVCGLN 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 VSDRCDFIRTNPDCHSDGGYLDYLEGIFCHFPPSLLPLAVTLYVSWLLYLFLILGVTAAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VSDRCDFIRTNPDCHSDGGYLDYLEGIFCHFPPSLLPLAVTLYVSWLLYLFLILGVTAAK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 FFCPNLSAISTTLKLSHNVAGVTFLAFGNGAPDIFSALVAFSDPHTAGLALGALFGAGVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FFCPNLSAISTTLKLSHNVAGVTFLAFGNGAPDIFSALVAFSDPHTAGLALGALFGAGVL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 VTTVVAGGITILHPFMAASRPFFRDIVFYMVAVFLTFLMLFRGRVTLAWALGYLGLYVFY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VTTVVAGGITILHPFMAASRPFFRDIVFYMVAVFLTFLMLFRGRVTLAWALGYLGLYVFY 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE6 VVTVILCTWIYQRQRRGSLFCPMPVTPEILSDSEEDRVSSNTNSYDYGDEYRPLFFYQET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VVTVILCTWIYQRQRRGSLFCPMPVTPEILSDSEEDRVSSNTNSYDYGDEYRPLFFYQET 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE6 TAQILVRALNPLDYMKWRRKSAYWKALKVFKLPVEFLLLLTVPVVDPDKDDQNWKRPLNC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TAQILVRALNPLDYMKWRRKSAYWKALKVFKLPVEFLLLLTVPVVDPDKDDQNWKRPLNC 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE6 LHLVISPLVVVLTLQSGTYGVYEIGGLVPVWVVVVIAGTALASVTFFATSDSQPPRLHWL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::. XP_016 LHLVISPLVVVLTLQSGTYGVYEIGGLVPVWVVVVIAGTALASVTFFATSDSQPPRLHWV 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE6 FAFLGFLTSALWINAAATEVVNILRSLGVVFRLSNTVLGLTLLAWGNSIGDAFSDFTLAR XP_016 RN >>XP_011537054 (OMIM: 609841) PREDICTED: sodium/potassiu (389 aa) initn: 2579 init1: 2579 opt: 2579 Z-score: 3113.7 bits: 585.5 E(85289): 1.1e-166 Smith-Waterman score: 2579; 100.0% identity (100.0% similar) in 389 aa overlap (196-584:1-389) 170 180 190 200 210 220 pF1KE6 TAGLALGALFGAGVLVTTVVAGGITILHPFMAASRPFFRDIVFYMVAVFLTFLMLFRGRV :::::::::::::::::::::::::::::: XP_011 MAASRPFFRDIVFYMVAVFLTFLMLFRGRV 10 20 30 230 240 250 260 270 280 pF1KE6 TLAWALGYLGLYVFYVVTVILCTWIYQRQRRGSLFCPMPVTPEILSDSEEDRVSSNTNSY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TLAWALGYLGLYVFYVVTVILCTWIYQRQRRGSLFCPMPVTPEILSDSEEDRVSSNTNSY 40 50 60 70 80 90 290 300 310 320 330 340 pF1KE6 DYGDEYRPLFFYQETTAQILVRALNPLDYMKWRRKSAYWKALKVFKLPVEFLLLLTVPVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DYGDEYRPLFFYQETTAQILVRALNPLDYMKWRRKSAYWKALKVFKLPVEFLLLLTVPVV 100 110 120 130 140 150 350 360 370 380 390 400 pF1KE6 DPDKDDQNWKRPLNCLHLVISPLVVVLTLQSGTYGVYEIGGLVPVWVVVVIAGTALASVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DPDKDDQNWKRPLNCLHLVISPLVVVLTLQSGTYGVYEIGGLVPVWVVVVIAGTALASVT 160 170 180 190 200 210 410 420 430 440 450 460 pF1KE6 FFATSDSQPPRLHWLFAFLGFLTSALWINAAATEVVNILRSLGVVFRLSNTVLGLTLLAW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FFATSDSQPPRLHWLFAFLGFLTSALWINAAATEVVNILRSLGVVFRLSNTVLGLTLLAW 220 230 240 250 260 270 470 480 490 500 510 520 pF1KE6 GNSIGDAFSDFTLARQGYPRMAFSACFGGIIFNILVGVGLGCLLQISRSHTEVKLEPDGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GNSIGDAFSDFTLARQGYPRMAFSACFGGIIFNILVGVGLGCLLQISRSHTEVKLEPDGL 280 290 300 310 320 330 530 540 550 560 570 580 pF1KE6 LVWVLAGALGLSLVFSLVSVPLQCFQLSRVYGFCLLLFYLNFLVVALLTEFGVIHLKSM ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LVWVLAGALGLSLVFSLVSVPLQCFQLSRVYGFCLLLFYLNFLVVALLTEFGVIHLKSM 340 350 360 370 380 >>XP_006719670 (OMIM: 609841) PREDICTED: sodium/potassiu (389 aa) initn: 2579 init1: 2579 opt: 2579 Z-score: 3113.7 bits: 585.5 E(85289): 1.1e-166 Smith-Waterman score: 2579; 100.0% identity (100.0% similar) in 389 aa overlap (196-584:1-389) 170 180 190 200 210 220 pF1KE6 TAGLALGALFGAGVLVTTVVAGGITILHPFMAASRPFFRDIVFYMVAVFLTFLMLFRGRV :::::::::::::::::::::::::::::: XP_006 MAASRPFFRDIVFYMVAVFLTFLMLFRGRV 10 20 30 230 240 250 260 270 280 pF1KE6 TLAWALGYLGLYVFYVVTVILCTWIYQRQRRGSLFCPMPVTPEILSDSEEDRVSSNTNSY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 TLAWALGYLGLYVFYVVTVILCTWIYQRQRRGSLFCPMPVTPEILSDSEEDRVSSNTNSY 40 50 60 70 80 90 290 300 310 320 330 340 pF1KE6 DYGDEYRPLFFYQETTAQILVRALNPLDYMKWRRKSAYWKALKVFKLPVEFLLLLTVPVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DYGDEYRPLFFYQETTAQILVRALNPLDYMKWRRKSAYWKALKVFKLPVEFLLLLTVPVV 100 110 120 130 140 150 350 360 370 380 390 400 pF1KE6 DPDKDDQNWKRPLNCLHLVISPLVVVLTLQSGTYGVYEIGGLVPVWVVVVIAGTALASVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DPDKDDQNWKRPLNCLHLVISPLVVVLTLQSGTYGVYEIGGLVPVWVVVVIAGTALASVT 160 170 180 190 200 210 410 420 430 440 450 460 pF1KE6 FFATSDSQPPRLHWLFAFLGFLTSALWINAAATEVVNILRSLGVVFRLSNTVLGLTLLAW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 FFATSDSQPPRLHWLFAFLGFLTSALWINAAATEVVNILRSLGVVFRLSNTVLGLTLLAW 220 230 240 250 260 270 470 480 490 500 510 520 pF1KE6 GNSIGDAFSDFTLARQGYPRMAFSACFGGIIFNILVGVGLGCLLQISRSHTEVKLEPDGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GNSIGDAFSDFTLARQGYPRMAFSACFGGIIFNILVGVGLGCLLQISRSHTEVKLEPDGL 280 290 300 310 320 330 530 540 550 560 570 580 pF1KE6 LVWVLAGALGLSLVFSLVSVPLQCFQLSRVYGFCLLLFYLNFLVVALLTEFGVIHLKSM ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LVWVLAGALGLSLVFSLVSVPLQCFQLSRVYGFCLLLFYLNFLVVALLTEFGVIHLKSM 340 350 360 370 380 >>NP_001317395 (OMIM: 609841) sodium/potassium/calcium e (528 aa) initn: 2344 init1: 2344 opt: 2345 Z-score: 2829.4 bits: 533.3 E(85289): 7.3e-151 Smith-Waterman score: 3405; 90.4% identity (90.4% similar) in 584 aa overlap (1-584:1-528) 10 20 30 40 50 60 pF1KE6 MAGRRLNLRWALSVLCVLLMAETVSGTRGSSTGAHISPQFPASGVNQTPVVDCRKVCGLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAGRRLNLRWALSVLCVLLMAETVSGTRGSSTGAHISPQFPASGVNQTPVVDCRKVCGLN 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 VSDRCDFIRTNPDCHSDGGYLDYLEGIFCHFPPSLLPLAVTLYVSWLLYLFLILGVTAAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VSDRCDFIRTNPDCHSDGGYLDYLEGIFCHFPPSLLPLAVTLYVSWLLYLFLILGVTAAK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 FFCPNLSAISTTLKLSHNVAGVTFLAFGNGAPDIFSALVAFSDPHTAGLALGALFGAGVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FFCPNLSAISTTLKLSHNVAGVTFLAFGNGAPDIFSALVAFSDPHTAGLALGALFG---- 130 140 150 160 170 190 200 210 220 230 240 pF1KE6 VTTVVAGGITILHPFMAASRPFFRDIVFYMVAVFLTFLMLFRGRVTLAWALGYLGLYVFY :::::::: NP_001 ----------------------------------------------------YLGLYVFY 180 250 260 270 280 290 300 pF1KE6 VVTVILCTWIYQRQRRGSLFCPMPVTPEILSDSEEDRVSSNTNSYDYGDEYRPLFFYQET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VVTVILCTWIYQRQRRGSLFCPMPVTPEILSDSEEDRVSSNTNSYDYGDEYRPLFFYQET 190 200 210 220 230 240 310 320 330 340 350 360 pF1KE6 TAQILVRALNPLDYMKWRRKSAYWKALKVFKLPVEFLLLLTVPVVDPDKDDQNWKRPLNC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TAQILVRALNPLDYMKWRRKSAYWKALKVFKLPVEFLLLLTVPVVDPDKDDQNWKRPLNC 250 260 270 280 290 300 370 380 390 400 410 420 pF1KE6 LHLVISPLVVVLTLQSGTYGVYEIGGLVPVWVVVVIAGTALASVTFFATSDSQPPRLHWL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LHLVISPLVVVLTLQSGTYGVYEIGGLVPVWVVVVIAGTALASVTFFATSDSQPPRLHWL 310 320 330 340 350 360 430 440 450 460 470 480 pF1KE6 FAFLGFLTSALWINAAATEVVNILRSLGVVFRLSNTVLGLTLLAWGNSIGDAFSDFTLAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FAFLGFLTSALWINAAATEVVNILRSLGVVFRLSNTVLGLTLLAWGNSIGDAFSDFTLAR 370 380 390 400 410 420 490 500 510 520 530 540 pF1KE6 QGYPRMAFSACFGGIIFNILVGVGLGCLLQISRSHTEVKLEPDGLLVWVLAGALGLSLVF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QGYPRMAFSACFGGIIFNILVGVGLGCLLQISRSHTEVKLEPDGLLVWVLAGALGLSLVF 430 440 450 460 470 480 550 560 570 580 pF1KE6 SLVSVPLQCFQLSRVYGFCLLLFYLNFLVVALLTEFGVIHLKSM :::::::::::::::::::::::::::::::::::::::::::: NP_001 SLVSVPLQCFQLSRVYGFCLLLFYLNFLVVALLTEFGVIHLKSM 490 500 510 520 >>NP_065740 (OMIM: 609839) sodium/potassium/calcium exch (644 aa) initn: 445 init1: 234 opt: 289 Z-score: 346.7 bits: 74.3 E(85289): 1.4e-12 Smith-Waterman score: 409; 25.3% identity (54.7% similar) in 534 aa overlap (99-578:109-632) 70 80 90 100 110 120 pF1KE6 RTNPDCHSDGGYLDYLEGIFCHFPPSLLPLAVTLYVSWLLYLFLILGVTAAKFFCPNLSA ::.:.: .:.: :... :: :.: NP_065 AGLRNSKNCTEPALHEFPNDIFTNEDRRQGAVVLHVLCAIYMFYALAIVCDDFFVPSLEK 80 90 100 110 120 130 130 140 150 160 170 180 pF1KE6 ISTTLKLSHNVAGVTFLAFGNGAPDIFSALVA-FSDPHTAGLALGALFGAGVLVTTVVAG : :.::..:::.::.: :..::..:..... : .:. :.. :..:. . : NP_065 ICERLHLSEDVAGATFMAAGSSAPELFTSVIGVFITKGDVGV--GTIVGSAVFNILCIIG 140 150 160 170 180 190 190 200 210 220 230 240 pF1KE6 --GITILHPFMAASRPFFRDIVFYMVAVFLTFLMLFRGRVTLAWALGYLGLYVFYVVTVI :. . .: ..:: ..: ..:. ..... .:. .: . .:..:.: . NP_065 VCGLFAGQVVALSSWCLLRDSIYYTLSVIALIVFIYDEKVSWWESLVLVLMYLIYIVIMK 200 210 220 230 240 250 250 260 270 280 290 pF1KE6 LCTWIYQ-RQRR----GSLFCPMPVTPEILSDSEEDRVSSNTNSYDYG--------DE-- . :.: .:: :.. . . :: ..:. : . .. .. :: NP_065 YNACIHQCFERRTKGAGNMVNGLANNAEIDDSSNCDATVVLLKKANFHRKASVIMVDELL 260 270 280 290 300 310 300 310 320 330 pF1KE6 --YRPLFFYQETTAQILVRALNP----LDY-----MKWRRKSAYWKALK------VFKLP : . ..:. .:.. . : :.. .. :.. .: ..:.: NP_065 SAYPHQLSFSEAGLRIMITSHFPPKTRLSMASRMLINERQRLINSRAYTNGESEVAIKIP 320 330 340 350 360 370 340 350 360 370 380 pF1KE6 VEFLLLL-TVPVVDPDK-------DD-----QNWKRPLNCLHLVISPLVVVLTLQSGTYG .. . : : ::. :: : . : . . : : NP_065 IKHTVENGTGPSSAPDRGVNGTRRDDVVAEAGNETENENEDNENDEEEEEDEDDDEGPYT 380 390 400 410 420 430 390 400 410 420 430 pF1KE6 VYEI--GGLVPV-WVVVVIAGTALASVTFFATSDSQPPRLHWLFAFL-GFLTSALWINAA .. : : : :. . :. : .:.. . . :: : :. : .:.::: : NP_065 PFDTPSGKLETVKWAFT----WPLSFVLYFTVPNCNKPR--WEKWFMVTFASSTLWIAAF 440 450 460 470 480 490 440 450 460 470 480 490 pF1KE6 ATEVVNILRSLGVVFRLSNTVLGLTLLAWGNSIGDAFSDFTLARQGYPRMAFSACFGGII . .: .. .: .. . ....:.:.:: :.:. : .... .::::. :: : .:. . NP_065 SYMMVWMVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGMGDMAVSNSIGSNV 500 510 520 530 540 550 500 510 520 530 540 550 pF1KE6 FNILVGVGLGCLLQ-ISRSH-TEVKLEPDGLLVWVLAGALGLSLVFSLVSVPLQCFQLSR :.::.:.:: :: .. .. . ..:. ::. : : : :. .. .: :. .::.. NP_065 FDILIGLGLPWALQTLAVDYGSYIRLNSRGLIYSV--GLLLASVFVTVFGVHLNKWQLDK 560 570 580 590 600 560 570 580 pF1KE6 VYGFCLLLFYLNFLVVALLTEFGVIHLKSM : ::.: :: ...:::.: NP_065 KLGCGCLLLYGVFLCFSIMTEFNVFTFVNLPMCGDH 610 620 630 640 >>XP_011534743 (OMIM: 210750,609840,615887) PREDICTED: s (316 aa) initn: 305 init1: 209 opt: 275 Z-score: 334.3 bits: 70.9 E(85289): 7e-12 Smith-Waterman score: 275; 27.6% identity (59.0% similar) in 239 aa overlap (342-578:73-303) 320 330 340 350 360 370 pF1KE6 LDYMKWRRKSAYWKALKVFKLPVEFLLLLTVPVVDPDKDDQNWKRPLNCLHLVISPLVVV ::: .:. .:: .. : : XP_011 NERQRLINSANGVSSKPLQNGRHENIENGNVPVENPEDPQQNQEQQPPPQPPPPEPEPVE 50 60 70 80 90 100 380 390 400 410 420 430 pF1KE6 LTLQSGTYGVYEIGGLVPVWVVVVIAGTALASVTFFATSDSQPPRLHWLFAFLGFLTSAL . : ..: : : :: . : . . . . :: . .: .. :.:..: XP_011 ADFLS-PFSVPEARGDKVKWVFTW----PLIFLLCVTIPNCSKPRWEKFF-MVTFITATL 110 120 130 140 150 440 450 460 470 480 490 pF1KE6 WINAAATEVVNILRSLGVVFRLSNTVLGLTLLAWGNSIGDAFSDFTLARQGYPRMAFSAC :: . . .: .. .: .. . ....:.:.:: :.:. : .... .:::: :: : XP_011 WIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGLGDMAVSNT 160 170 180 190 200 210 500 510 520 530 540 pF1KE6 FGGIIFNILVGVGL--GCLLQISRSHTEVKLEPDGLLVWVLAGALGLSLVFSLVSVPLQC .:. .:.::::.:. : .. . ::.. :: :. .. :: :........ :. XP_011 IGSNVFDILVGLGVPWGLQTMVVNYGSTVKINSRGL-VYSVVLLLG-SVALTVLGIHLNK 220 230 240 250 260 270 550 560 570 580 pF1KE6 FQLSRVYGFCLLLFYLNFLVVALLTEFGVIHLKSM ..:.: : .:..: :: ... ::.: XP_011 WRLDRKLGVYVLVLYAIFLCFSIMIEFNVFTFVNLPMCREDD 280 290 300 310 >>XP_011534744 (OMIM: 210750,609840,615887) PREDICTED: s (316 aa) initn: 305 init1: 209 opt: 275 Z-score: 334.3 bits: 70.9 E(85289): 7e-12 Smith-Waterman score: 275; 27.6% identity (59.0% similar) in 239 aa overlap (342-578:73-303) 320 330 340 350 360 370 pF1KE6 LDYMKWRRKSAYWKALKVFKLPVEFLLLLTVPVVDPDKDDQNWKRPLNCLHLVISPLVVV ::: .:. .:: .. : : XP_011 NERQRLINSANGVSSKPLQNGRHENIENGNVPVENPEDPQQNQEQQPPPQPPPPEPEPVE 50 60 70 80 90 100 380 390 400 410 420 430 pF1KE6 LTLQSGTYGVYEIGGLVPVWVVVVIAGTALASVTFFATSDSQPPRLHWLFAFLGFLTSAL . : ..: : : :: . : . . . . :: . .: .. :.:..: XP_011 ADFLS-PFSVPEARGDKVKWVFTW----PLIFLLCVTIPNCSKPRWEKFF-MVTFITATL 110 120 130 140 150 440 450 460 470 480 490 pF1KE6 WINAAATEVVNILRSLGVVFRLSNTVLGLTLLAWGNSIGDAFSDFTLARQGYPRMAFSAC :: . . .: .. .: .. . ....:.:.:: :.:. : .... .:::: :: : XP_011 WIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGLGDMAVSNT 160 170 180 190 200 210 500 510 520 530 540 pF1KE6 FGGIIFNILVGVGL--GCLLQISRSHTEVKLEPDGLLVWVLAGALGLSLVFSLVSVPLQC .:. .:.::::.:. : .. . ::.. :: :. .. :: :........ :. XP_011 IGSNVFDILVGLGVPWGLQTMVVNYGSTVKINSRGL-VYSVVLLLG-SVALTVLGIHLNK 220 230 240 250 260 270 550 560 570 580 pF1KE6 FQLSRVYGFCLLLFYLNFLVVALLTEFGVIHLKSM ..:.: : .:..: :: ... ::.: XP_011 WRLDRKLGVYVLVLYAIFLCFSIMIEFNVFTFVNLPMCREDD 280 290 300 310 >>XP_011534742 (OMIM: 210750,609840,615887) PREDICTED: s (372 aa) initn: 305 init1: 209 opt: 275 Z-score: 333.3 bits: 71.0 E(85289): 8e-12 Smith-Waterman score: 275; 27.6% identity (59.0% similar) in 239 aa overlap (342-578:129-359) 320 330 340 350 360 370 pF1KE6 LDYMKWRRKSAYWKALKVFKLPVEFLLLLTVPVVDPDKDDQNWKRPLNCLHLVISPLVVV ::: .:. .:: .. : : XP_011 NERQRLINSANGVSSKPLQNGRHENIENGNVPVENPEDPQQNQEQQPPPQPPPPEPEPVE 100 110 120 130 140 150 380 390 400 410 420 430 pF1KE6 LTLQSGTYGVYEIGGLVPVWVVVVIAGTALASVTFFATSDSQPPRLHWLFAFLGFLTSAL . : ..: : : :: . : . . . . :: . .: .. :.:..: XP_011 ADFLS-PFSVPEARGDKVKWVFTW----PLIFLLCVTIPNCSKPRWEKFF-MVTFITATL 160 170 180 190 200 210 440 450 460 470 480 490 pF1KE6 WINAAATEVVNILRSLGVVFRLSNTVLGLTLLAWGNSIGDAFSDFTLARQGYPRMAFSAC :: . . .: .. .: .. . ....:.:.:: :.:. : .... .:::: :: : XP_011 WIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGLGDMAVSNT 220 230 240 250 260 270 500 510 520 530 540 pF1KE6 FGGIIFNILVGVGL--GCLLQISRSHTEVKLEPDGLLVWVLAGALGLSLVFSLVSVPLQC .:. .:.::::.:. : .. . ::.. :: :. .. :: :........ :. XP_011 IGSNVFDILVGLGVPWGLQTMVVNYGSTVKINSRGL-VYSVVLLLG-SVALTVLGIHLNK 280 290 300 310 320 330 550 560 570 580 pF1KE6 FQLSRVYGFCLLLFYLNFLVVALLTEFGVIHLKSM ..:.: : .:..: :: ... ::.: XP_011 WRLDRKLGVYVLVLYAIFLCFSIMIEFNVFTFVNLPMCREDD 340 350 360 370 584 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 13:46:30 2016 done: Tue Nov 8 13:46:32 2016 Total Scan time: 9.260 Total Display time: 0.070 Function used was FASTA [36.3.4 Apr, 2011]