FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE0962, 503 aa 1>>>pF1KE0962 503 - 503 aa - 503 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 8.1727+/-0.000557; mu= 6.5352+/- 0.033 mean_var=656.1673+/-152.270, 0's: 0 Z-trim(116.0): 236 B-trim: 0 in 0/53 Lambda= 0.050069 statistics sampled from 26573 (26797) to 26573 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.673), E-opt: 0.2 (0.314), width: 16 Scan time: 9.980 The best scores are: opt bits E(85289) XP_005269292 (OMIM: 600376,601284) PREDICTED: seri ( 503) 3468 266.8 1e-70 NP_000011 (OMIM: 600376,601284) serine/threonine-p ( 503) 3468 266.8 1e-70 NP_001070869 (OMIM: 600376,601284) serine/threonin ( 503) 3468 266.8 1e-70 XP_011537310 (OMIM: 600376,601284) PREDICTED: seri ( 413) 2022 162.2 2.6e-39 XP_011510410 (OMIM: 102576,135100) PREDICTED: acti ( 509) 1985 159.7 1.8e-38 XP_006712888 (OMIM: 102576,135100) PREDICTED: acti ( 509) 1985 159.7 1.8e-38 XP_005246996 (OMIM: 102576,135100) PREDICTED: acti ( 509) 1985 159.7 1.8e-38 XP_011510408 (OMIM: 102576,135100) PREDICTED: acti ( 509) 1985 159.7 1.8e-38 XP_011510409 (OMIM: 102576,135100) PREDICTED: acti ( 509) 1985 159.7 1.8e-38 NP_001096 (OMIM: 102576,135100) activin receptor t ( 509) 1985 159.7 1.8e-38 NP_001104537 (OMIM: 102576,135100) activin recepto ( 509) 1985 159.7 1.8e-38 XP_005246997 (OMIM: 102576,135100) PREDICTED: acti ( 509) 1985 159.7 1.8e-38 NP_004320 (OMIM: 174900,601299,610069) bone morpho ( 532) 1454 121.4 6.6e-27 XP_011538406 (OMIM: 174900,601299,610069) PREDICTE ( 532) 1454 121.4 6.6e-27 XP_011538405 (OMIM: 174900,601299,610069) PREDICTE ( 532) 1454 121.4 6.6e-27 NP_004293 (OMIM: 601300) activin receptor type-1B ( 505) 1437 120.1 1.5e-26 NP_001293139 (OMIM: 132800,190181) TGF-beta recept ( 507) 1436 120.0 1.6e-26 NP_001194 (OMIM: 112600,603248,609441,616849) bone ( 502) 1434 119.9 1.7e-26 XP_016864047 (OMIM: 112600,603248,609441,616849) P ( 502) 1434 119.9 1.7e-26 XP_011530503 (OMIM: 112600,603248,609441,616849) P ( 502) 1434 119.9 1.7e-26 NP_001243723 (OMIM: 112600,603248,609441,616849) b ( 502) 1434 119.9 1.7e-26 NP_001243721 (OMIM: 112600,603248,609441,616849) b ( 502) 1434 119.9 1.7e-26 XP_016864050 (OMIM: 112600,603248,609441,616849) P ( 502) 1434 119.9 1.7e-26 XP_016864048 (OMIM: 112600,603248,609441,616849) P ( 502) 1434 119.9 1.7e-26 XP_016864049 (OMIM: 112600,603248,609441,616849) P ( 502) 1434 119.9 1.7e-26 NP_004603 (OMIM: 132800,190181) TGF-beta receptor ( 503) 1434 119.9 1.8e-26 NP_001243722 (OMIM: 112600,603248,609441,616849) b ( 532) 1434 119.9 1.8e-26 XP_016870552 (OMIM: 132800,190181) PREDICTED: TGF- ( 438) 1422 118.9 3e-26 XP_011517250 (OMIM: 132800,190181) PREDICTED: TGF- ( 438) 1422 118.9 3e-26 XP_011517251 (OMIM: 132800,190181) PREDICTED: TGF- ( 434) 1420 118.8 3.3e-26 NP_660302 (OMIM: 608981) activin receptor type-1C ( 493) 1418 118.7 3.9e-26 NP_064732 (OMIM: 601300) activin receptor type-1B ( 453) 1404 117.6 7.5e-26 NP_001104501 (OMIM: 608981) activin receptor type- ( 443) 1392 116.7 1.4e-25 XP_011517252 (OMIM: 132800,190181) PREDICTED: TGF- ( 357) 1349 113.5 1.1e-24 NP_001124388 (OMIM: 132800,190181) TGF-beta recept ( 426) 1349 113.6 1.2e-24 NP_001104502 (OMIM: 608981) activin receptor type- ( 413) 1278 108.5 4e-23 XP_016875690 (OMIM: 601300) PREDICTED: activin rec ( 381) 978 86.7 1.3e-16 XP_016875688 (OMIM: 601300) PREDICTED: activin rec ( 494) 911 82.1 4.1e-15 XP_016875689 (OMIM: 601300) PREDICTED: activin rec ( 494) 911 82.1 4.1e-15 NP_064733 (OMIM: 601300) activin receptor type-1B ( 546) 911 82.2 4.3e-15 NP_001104503 (OMIM: 608981) activin receptor type- ( 336) 888 80.1 1.1e-14 XP_016862595 (OMIM: 133239,190182,610168,614331) P ( 532) 717 68.1 7e-11 XP_011532347 (OMIM: 133239,190182,610168,614331) P ( 532) 717 68.1 7e-11 NP_003233 (OMIM: 133239,190182,610168,614331) TGF- ( 567) 717 68.2 7.2e-11 XP_011532345 (OMIM: 133239,190182,610168,614331) P ( 576) 717 68.2 7.2e-11 NP_001020018 (OMIM: 133239,190182,610168,614331) T ( 592) 717 68.2 7.3e-11 NP_001265509 (OMIM: 102581) activin receptor type- ( 405) 707 67.2 1e-10 NP_001265508 (OMIM: 102581) activin receptor type- ( 513) 707 67.4 1.1e-10 NP_001607 (OMIM: 102581) activin receptor type-2A ( 513) 707 67.4 1.1e-10 XP_016863005 (OMIM: 602730,613751) PREDICTED: acti ( 511) 678 65.3 4.8e-10 >>XP_005269292 (OMIM: 600376,601284) PREDICTED: serine/t (503 aa) initn: 3468 init1: 3468 opt: 3468 Z-score: 1390.5 bits: 266.8 E(85289): 1e-70 Smith-Waterman score: 3468; 100.0% identity (100.0% similar) in 503 aa overlap (1-503:1-503) 10 20 30 40 50 60 pF1KE0 MTLGSPRKGLLMLLMALVTQGDPVKPSRGPLVTCTCESPHCKGPTCRGAWCTVVLVREEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MTLGSPRKGLLMLLMALVTQGDPVKPSRGPLVTCTCESPHCKGPTCRGAWCTVVLVREEG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 RHPQEHRGCGNLHRELCRGRPTEFVNHYCCDSHLCNHNVSLVLEATQPPSEQPGTDGQLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RHPQEHRGCGNLHRELCRGRPTEFVNHYCCDSHLCNHNVSLVLEATQPPSEQPGTDGQLA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 LILGPVLALLALVALGVLGLWHVRRRQEKQRGLHSELGESSLILKASEQGDSMLGDLLDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LILGPVLALLALVALGVLGLWHVRRRQEKQRGLHSELGESSLILKASEQGDSMLGDLLDS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 DCTTGSGSGLPFLVQRTVARQVALVECVGKGRYGEVWRGLWHGESVAVKIFSSRDEQSWF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DCTTGSGSGLPFLVQRTVARQVALVECVGKGRYGEVWRGLWHGESVAVKIFSSRDEQSWF 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 RETEIYNTVLLRHDNILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RETEIYNTVLLRHDNILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLAL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE0 RLAVSAACGLAHLHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RLAVSAACGLAHLHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSD 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE0 YLDIGNNPRVGTKRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIARRTIVNGIVED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 YLDIGNNPRVGTKRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIARRTIVNGIVED 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE0 YRPPFYDVVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 YRPPFYDVVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARL 430 440 450 460 470 480 490 500 pF1KE0 TALRIKKTLQKISNSPEKPKVIQ ::::::::::::::::::::::: XP_005 TALRIKKTLQKISNSPEKPKVIQ 490 500 >>NP_000011 (OMIM: 600376,601284) serine/threonine-prote (503 aa) initn: 3468 init1: 3468 opt: 3468 Z-score: 1390.5 bits: 266.8 E(85289): 1e-70 Smith-Waterman score: 3468; 100.0% identity (100.0% similar) in 503 aa overlap (1-503:1-503) 10 20 30 40 50 60 pF1KE0 MTLGSPRKGLLMLLMALVTQGDPVKPSRGPLVTCTCESPHCKGPTCRGAWCTVVLVREEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 MTLGSPRKGLLMLLMALVTQGDPVKPSRGPLVTCTCESPHCKGPTCRGAWCTVVLVREEG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 RHPQEHRGCGNLHRELCRGRPTEFVNHYCCDSHLCNHNVSLVLEATQPPSEQPGTDGQLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 RHPQEHRGCGNLHRELCRGRPTEFVNHYCCDSHLCNHNVSLVLEATQPPSEQPGTDGQLA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 LILGPVLALLALVALGVLGLWHVRRRQEKQRGLHSELGESSLILKASEQGDSMLGDLLDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 LILGPVLALLALVALGVLGLWHVRRRQEKQRGLHSELGESSLILKASEQGDSMLGDLLDS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 DCTTGSGSGLPFLVQRTVARQVALVECVGKGRYGEVWRGLWHGESVAVKIFSSRDEQSWF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 DCTTGSGSGLPFLVQRTVARQVALVECVGKGRYGEVWRGLWHGESVAVKIFSSRDEQSWF 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 RETEIYNTVLLRHDNILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 RETEIYNTVLLRHDNILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLAL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE0 RLAVSAACGLAHLHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 RLAVSAACGLAHLHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSD 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE0 YLDIGNNPRVGTKRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIARRTIVNGIVED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 YLDIGNNPRVGTKRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIARRTIVNGIVED 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE0 YRPPFYDVVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 YRPPFYDVVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARL 430 440 450 460 470 480 490 500 pF1KE0 TALRIKKTLQKISNSPEKPKVIQ ::::::::::::::::::::::: NP_000 TALRIKKTLQKISNSPEKPKVIQ 490 500 >>NP_001070869 (OMIM: 600376,601284) serine/threonine-pr (503 aa) initn: 3468 init1: 3468 opt: 3468 Z-score: 1390.5 bits: 266.8 E(85289): 1e-70 Smith-Waterman score: 3468; 100.0% identity (100.0% similar) in 503 aa overlap (1-503:1-503) 10 20 30 40 50 60 pF1KE0 MTLGSPRKGLLMLLMALVTQGDPVKPSRGPLVTCTCESPHCKGPTCRGAWCTVVLVREEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MTLGSPRKGLLMLLMALVTQGDPVKPSRGPLVTCTCESPHCKGPTCRGAWCTVVLVREEG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 RHPQEHRGCGNLHRELCRGRPTEFVNHYCCDSHLCNHNVSLVLEATQPPSEQPGTDGQLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RHPQEHRGCGNLHRELCRGRPTEFVNHYCCDSHLCNHNVSLVLEATQPPSEQPGTDGQLA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 LILGPVLALLALVALGVLGLWHVRRRQEKQRGLHSELGESSLILKASEQGDSMLGDLLDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LILGPVLALLALVALGVLGLWHVRRRQEKQRGLHSELGESSLILKASEQGDSMLGDLLDS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 DCTTGSGSGLPFLVQRTVARQVALVECVGKGRYGEVWRGLWHGESVAVKIFSSRDEQSWF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DCTTGSGSGLPFLVQRTVARQVALVECVGKGRYGEVWRGLWHGESVAVKIFSSRDEQSWF 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 RETEIYNTVLLRHDNILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RETEIYNTVLLRHDNILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLAL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE0 RLAVSAACGLAHLHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RLAVSAACGLAHLHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSD 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE0 YLDIGNNPRVGTKRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIARRTIVNGIVED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YLDIGNNPRVGTKRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIARRTIVNGIVED 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE0 YRPPFYDVVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YRPPFYDVVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARL 430 440 450 460 470 480 490 500 pF1KE0 TALRIKKTLQKISNSPEKPKVIQ ::::::::::::::::::::::: NP_001 TALRIKKTLQKISNSPEKPKVIQ 490 500 >>XP_011537310 (OMIM: 600376,601284) PREDICTED: serine/t (413 aa) initn: 2781 init1: 2022 opt: 2022 Z-score: 826.6 bits: 162.2 E(85289): 2.6e-39 Smith-Waterman score: 2577; 79.3% identity (79.3% similar) in 503 aa overlap (1-503:15-413) 10 20 30 40 pF1KE0 MTLGSPRKGLLMLLMALVTQGDPVKPSRGPLVTCTCESPHCKGPTC :::::::::::::::::::::::::::::::::::::::::::::: XP_011 MALTPPLLLLSAGTMTLGSPRKGLLMLLMALVTQGDPVKPSRGPLVTCTCESPHCKGPTC 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE0 RGAWCTVVLVREEGRHPQEHRGCGNLHRELCRGRPTEFVNHYCCDSHLCNHNVSLVLEAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RGAWCTVVLVREEGRHPQEHRGCGNLHRELCRGRPTEFVNHYCCDSHLCNHNVSLVLE-- 70 80 90 100 110 110 120 130 140 150 160 pF1KE0 QPPSEQPGTDGQLALILGPVLALLALVALGVLGLWHVRRRQEKQRGLHSELGESSLILKA XP_011 ------------------------------------------------------------ 170 180 190 200 210 220 pF1KE0 SEQGDSMLGDLLDSDCTTGSGSGLPFLVQRTVARQVALVECVGKGRYGEVWRGLWHGESV :::::::::::::::::: XP_011 ------------------------------------------GKGRYGEVWRGLWHGESV 120 130 230 240 250 260 270 280 pF1KE0 AVKIFSSRDEQSWFRETEIYNTVLLRHDNILGFIASDMTSRNSSTQLWLITHYHEHGSLY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AVKIFSSRDEQSWFRETEIYNTVLLRHDNILGFIASDMTSRNSSTQLWLITHYHEHGSLY 140 150 160 170 180 190 290 300 310 320 330 340 pF1KE0 DFLQRQTLEPHLALRLAVSAACGLAHLHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DFLQRQTLEPHLALRLAVSAACGLAHLHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCI 200 210 220 230 240 250 350 360 370 380 390 400 pF1KE0 ADLGLAVMHSQGSDYLDIGNNPRVGTKRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ADLGLAVMHSQGSDYLDIGNNPRVGTKRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLW 260 270 280 290 300 310 410 420 430 440 450 460 pF1KE0 EIARRTIVNGIVEDYRPPFYDVVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EIARRTIVNGIVEDYRPPFYDVVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQ 320 330 340 350 360 370 470 480 490 500 pF1KE0 MMRECWYPNPSARLTALRIKKTLQKISNSPEKPKVIQ ::::::::::::::::::::::::::::::::::::: XP_011 MMRECWYPNPSARLTALRIKKTLQKISNSPEKPKVIQ 380 390 400 410 >>XP_011510410 (OMIM: 102576,135100) PREDICTED: activin (509 aa) initn: 1898 init1: 1832 opt: 1985 Z-score: 811.5 bits: 159.7 E(85289): 1.8e-38 Smith-Waterman score: 1985; 61.1% identity (79.2% similar) in 501 aa overlap (11-500:10-506) 10 20 30 40 50 pF1KE0 MTLGSPRKGLLMLLMALVTQG-DPVKPSRGP-LVTCTCESPHCKGPT-CRGAWCTVVLVR .....:: . . . ::. .: : :.::. : . :.: : : XP_011 MVDGVMILPVLIMIALPSPSMEDEKPKVNPKLYMCVCEGLSCGNEDHCEGQQCFSSLSI 10 20 30 40 50 60 70 80 90 100 110 pF1KE0 EEGRHPQEHRGCGNLHRE---LCRGRPTEFVNHYCCDSHLCNHNVSLVLEATQPPSEQPG ..: : . .:: ..... :. :. ::.. ::.:.. : :. : :: XP_011 NDGFHVYQ-KGCFQVYEQGKMTCKTPPSPGQAVECCQGDWCNRNITAQLP-TKGKSF-PG 60 70 80 90 100 110 120 130 140 150 160 pF1KE0 TDG---QLALILGPVLALLALVA--LGVLGLWHVRRRQEKQRGLHSELGESSLILKASEQ :.. ...::. :. . :.: ::: :: ::. : : .. ... XP_011 TQNFHLEVGLIILSVVFAVCLLACLLGVALRKFKRRNQERLNPRDVEYGTIEGLI-TTNV 120 130 140 150 160 170 170 180 190 200 210 220 pF1KE0 GDSMLGDLLDSDCTTGSGSGLPFLVQRTVARQVALVECVGKGRYGEVWRGLWHGESVAVK ::: :.:::: .::.:::::::::::::::::..:.:::::::::::::: :.::.:::: XP_011 GDSTLADLLDHSCTSGSGSGLPFLVQRTVARQITLLECVGKGRYGEVWRGSWQGENVAVK 180 190 200 210 220 230 230 240 250 260 270 280 pF1KE0 IFSSRDEQSWFRETEIYNTVLLRHDNILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFL :::::::.:::::::.::::.:::.:::::::::::::.::::::::::::: :::::.: XP_011 IFSSRDEKSWFRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYL 240 250 260 270 280 290 290 300 310 320 330 340 pF1KE0 QRQTLEPHLALRLAVSAACGLAHLHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADL : ::. ::...: : ::::::.:::::::::::::::.::.:.:::.: ::::::: XP_011 QLTTLDTVSCLRIVLSIASGLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADL 300 310 320 330 340 350 350 360 370 380 390 400 pF1KE0 GLAVMHSQGSDYLDIGNNPRVGTKRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIA ::::::::... ::.::::::::::::::::::: :..:::.::: .:::::::::::.: XP_011 GLAVMHSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVA 360 370 380 390 400 410 410 420 430 440 450 460 pF1KE0 RRTIVNGIVEDYRPPFYDVVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMR :: . :::::::.::::::::::::::::.:::::::: :.:::: .::.:..::..:. XP_011 RRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMK 420 430 440 450 460 470 470 480 490 500 pF1KE0 ECWYPNPSARLTALRIKKTLQKISNSPEKPKVIQ :::: ::::::::::::::: ::.:: .: : XP_011 ECWYQNPSARLTALRIKKTLTKIDNSLDKLKTDC 480 490 500 >>XP_006712888 (OMIM: 102576,135100) PREDICTED: activin (509 aa) initn: 1898 init1: 1832 opt: 1985 Z-score: 811.5 bits: 159.7 E(85289): 1.8e-38 Smith-Waterman score: 1985; 61.1% identity (79.2% similar) in 501 aa overlap (11-500:10-506) 10 20 30 40 50 pF1KE0 MTLGSPRKGLLMLLMALVTQG-DPVKPSRGP-LVTCTCESPHCKGPT-CRGAWCTVVLVR .....:: . . . ::. .: : :.::. : . :.: : : XP_006 MVDGVMILPVLIMIALPSPSMEDEKPKVNPKLYMCVCEGLSCGNEDHCEGQQCFSSLSI 10 20 30 40 50 60 70 80 90 100 110 pF1KE0 EEGRHPQEHRGCGNLHRE---LCRGRPTEFVNHYCCDSHLCNHNVSLVLEATQPPSEQPG ..: : . .:: ..... :. :. ::.. ::.:.. : :. : :: XP_006 NDGFHVYQ-KGCFQVYEQGKMTCKTPPSPGQAVECCQGDWCNRNITAQLP-TKGKSF-PG 60 70 80 90 100 110 120 130 140 150 160 pF1KE0 TDG---QLALILGPVLALLALVA--LGVLGLWHVRRRQEKQRGLHSELGESSLILKASEQ :.. ...::. :. . :.: ::: :: ::. : : .. ... XP_006 TQNFHLEVGLIILSVVFAVCLLACLLGVALRKFKRRNQERLNPRDVEYGTIEGLI-TTNV 120 130 140 150 160 170 170 180 190 200 210 220 pF1KE0 GDSMLGDLLDSDCTTGSGSGLPFLVQRTVARQVALVECVGKGRYGEVWRGLWHGESVAVK ::: :.:::: .::.:::::::::::::::::..:.:::::::::::::: :.::.:::: XP_006 GDSTLADLLDHSCTSGSGSGLPFLVQRTVARQITLLECVGKGRYGEVWRGSWQGENVAVK 180 190 200 210 220 230 230 240 250 260 270 280 pF1KE0 IFSSRDEQSWFRETEIYNTVLLRHDNILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFL :::::::.:::::::.::::.:::.:::::::::::::.::::::::::::: :::::.: XP_006 IFSSRDEKSWFRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYL 240 250 260 270 280 290 290 300 310 320 330 340 pF1KE0 QRQTLEPHLALRLAVSAACGLAHLHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADL : ::. ::...: : ::::::.:::::::::::::::.::.:.:::.: ::::::: XP_006 QLTTLDTVSCLRIVLSIASGLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADL 300 310 320 330 340 350 350 360 370 380 390 400 pF1KE0 GLAVMHSQGSDYLDIGNNPRVGTKRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIA ::::::::... ::.::::::::::::::::::: :..:::.::: .:::::::::::.: XP_006 GLAVMHSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVA 360 370 380 390 400 410 410 420 430 440 450 460 pF1KE0 RRTIVNGIVEDYRPPFYDVVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMR :: . :::::::.::::::::::::::::.:::::::: :.:::: .::.:..::..:. XP_006 RRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMK 420 430 440 450 460 470 470 480 490 500 pF1KE0 ECWYPNPSARLTALRIKKTLQKISNSPEKPKVIQ :::: ::::::::::::::: ::.:: .: : XP_006 ECWYQNPSARLTALRIKKTLTKIDNSLDKLKTDC 480 490 500 >>XP_005246996 (OMIM: 102576,135100) PREDICTED: activin (509 aa) initn: 1898 init1: 1832 opt: 1985 Z-score: 811.5 bits: 159.7 E(85289): 1.8e-38 Smith-Waterman score: 1985; 61.1% identity (79.2% similar) in 501 aa overlap (11-500:10-506) 10 20 30 40 50 pF1KE0 MTLGSPRKGLLMLLMALVTQG-DPVKPSRGP-LVTCTCESPHCKGPT-CRGAWCTVVLVR .....:: . . . ::. .: : :.::. : . :.: : : XP_005 MVDGVMILPVLIMIALPSPSMEDEKPKVNPKLYMCVCEGLSCGNEDHCEGQQCFSSLSI 10 20 30 40 50 60 70 80 90 100 110 pF1KE0 EEGRHPQEHRGCGNLHRE---LCRGRPTEFVNHYCCDSHLCNHNVSLVLEATQPPSEQPG ..: : . .:: ..... :. :. ::.. ::.:.. : :. : :: XP_005 NDGFHVYQ-KGCFQVYEQGKMTCKTPPSPGQAVECCQGDWCNRNITAQLP-TKGKSF-PG 60 70 80 90 100 110 120 130 140 150 160 pF1KE0 TDG---QLALILGPVLALLALVA--LGVLGLWHVRRRQEKQRGLHSELGESSLILKASEQ :.. ...::. :. . :.: ::: :: ::. : : .. ... XP_005 TQNFHLEVGLIILSVVFAVCLLACLLGVALRKFKRRNQERLNPRDVEYGTIEGLI-TTNV 120 130 140 150 160 170 170 180 190 200 210 220 pF1KE0 GDSMLGDLLDSDCTTGSGSGLPFLVQRTVARQVALVECVGKGRYGEVWRGLWHGESVAVK ::: :.:::: .::.:::::::::::::::::..:.:::::::::::::: :.::.:::: XP_005 GDSTLADLLDHSCTSGSGSGLPFLVQRTVARQITLLECVGKGRYGEVWRGSWQGENVAVK 180 190 200 210 220 230 230 240 250 260 270 280 pF1KE0 IFSSRDEQSWFRETEIYNTVLLRHDNILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFL :::::::.:::::::.::::.:::.:::::::::::::.::::::::::::: :::::.: XP_005 IFSSRDEKSWFRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYL 240 250 260 270 280 290 290 300 310 320 330 340 pF1KE0 QRQTLEPHLALRLAVSAACGLAHLHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADL : ::. ::...: : ::::::.:::::::::::::::.::.:.:::.: ::::::: XP_005 QLTTLDTVSCLRIVLSIASGLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADL 300 310 320 330 340 350 350 360 370 380 390 400 pF1KE0 GLAVMHSQGSDYLDIGNNPRVGTKRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIA ::::::::... ::.::::::::::::::::::: :..:::.::: .:::::::::::.: XP_005 GLAVMHSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVA 360 370 380 390 400 410 410 420 430 440 450 460 pF1KE0 RRTIVNGIVEDYRPPFYDVVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMR :: . :::::::.::::::::::::::::.:::::::: :.:::: .::.:..::..:. XP_005 RRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMK 420 430 440 450 460 470 470 480 490 500 pF1KE0 ECWYPNPSARLTALRIKKTLQKISNSPEKPKVIQ :::: ::::::::::::::: ::.:: .: : XP_005 ECWYQNPSARLTALRIKKTLTKIDNSLDKLKTDC 480 490 500 >>XP_011510408 (OMIM: 102576,135100) PREDICTED: activin (509 aa) initn: 1898 init1: 1832 opt: 1985 Z-score: 811.5 bits: 159.7 E(85289): 1.8e-38 Smith-Waterman score: 1985; 61.1% identity (79.2% similar) in 501 aa overlap (11-500:10-506) 10 20 30 40 50 pF1KE0 MTLGSPRKGLLMLLMALVTQG-DPVKPSRGP-LVTCTCESPHCKGPT-CRGAWCTVVLVR .....:: . . . ::. .: : :.::. : . :.: : : XP_011 MVDGVMILPVLIMIALPSPSMEDEKPKVNPKLYMCVCEGLSCGNEDHCEGQQCFSSLSI 10 20 30 40 50 60 70 80 90 100 110 pF1KE0 EEGRHPQEHRGCGNLHRE---LCRGRPTEFVNHYCCDSHLCNHNVSLVLEATQPPSEQPG ..: : . .:: ..... :. :. ::.. ::.:.. : :. : :: XP_011 NDGFHVYQ-KGCFQVYEQGKMTCKTPPSPGQAVECCQGDWCNRNITAQLP-TKGKSF-PG 60 70 80 90 100 110 120 130 140 150 160 pF1KE0 TDG---QLALILGPVLALLALVA--LGVLGLWHVRRRQEKQRGLHSELGESSLILKASEQ :.. ...::. :. . :.: ::: :: ::. : : .. ... XP_011 TQNFHLEVGLIILSVVFAVCLLACLLGVALRKFKRRNQERLNPRDVEYGTIEGLI-TTNV 120 130 140 150 160 170 170 180 190 200 210 220 pF1KE0 GDSMLGDLLDSDCTTGSGSGLPFLVQRTVARQVALVECVGKGRYGEVWRGLWHGESVAVK ::: :.:::: .::.:::::::::::::::::..:.:::::::::::::: :.::.:::: XP_011 GDSTLADLLDHSCTSGSGSGLPFLVQRTVARQITLLECVGKGRYGEVWRGSWQGENVAVK 180 190 200 210 220 230 230 240 250 260 270 280 pF1KE0 IFSSRDEQSWFRETEIYNTVLLRHDNILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFL :::::::.:::::::.::::.:::.:::::::::::::.::::::::::::: :::::.: XP_011 IFSSRDEKSWFRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYL 240 250 260 270 280 290 290 300 310 320 330 340 pF1KE0 QRQTLEPHLALRLAVSAACGLAHLHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADL : ::. ::...: : ::::::.:::::::::::::::.::.:.:::.: ::::::: XP_011 QLTTLDTVSCLRIVLSIASGLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADL 300 310 320 330 340 350 350 360 370 380 390 400 pF1KE0 GLAVMHSQGSDYLDIGNNPRVGTKRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIA ::::::::... ::.::::::::::::::::::: :..:::.::: .:::::::::::.: XP_011 GLAVMHSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVA 360 370 380 390 400 410 410 420 430 440 450 460 pF1KE0 RRTIVNGIVEDYRPPFYDVVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMR :: . :::::::.::::::::::::::::.:::::::: :.:::: .::.:..::..:. XP_011 RRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMK 420 430 440 450 460 470 470 480 490 500 pF1KE0 ECWYPNPSARLTALRIKKTLQKISNSPEKPKVIQ :::: ::::::::::::::: ::.:: .: : XP_011 ECWYQNPSARLTALRIKKTLTKIDNSLDKLKTDC 480 490 500 >>XP_011510409 (OMIM: 102576,135100) PREDICTED: activin (509 aa) initn: 1898 init1: 1832 opt: 1985 Z-score: 811.5 bits: 159.7 E(85289): 1.8e-38 Smith-Waterman score: 1985; 61.1% identity (79.2% similar) in 501 aa overlap (11-500:10-506) 10 20 30 40 50 pF1KE0 MTLGSPRKGLLMLLMALVTQG-DPVKPSRGP-LVTCTCESPHCKGPT-CRGAWCTVVLVR .....:: . . . ::. .: : :.::. : . :.: : : XP_011 MVDGVMILPVLIMIALPSPSMEDEKPKVNPKLYMCVCEGLSCGNEDHCEGQQCFSSLSI 10 20 30 40 50 60 70 80 90 100 110 pF1KE0 EEGRHPQEHRGCGNLHRE---LCRGRPTEFVNHYCCDSHLCNHNVSLVLEATQPPSEQPG ..: : . .:: ..... :. :. ::.. ::.:.. : :. : :: XP_011 NDGFHVYQ-KGCFQVYEQGKMTCKTPPSPGQAVECCQGDWCNRNITAQLP-TKGKSF-PG 60 70 80 90 100 110 120 130 140 150 160 pF1KE0 TDG---QLALILGPVLALLALVA--LGVLGLWHVRRRQEKQRGLHSELGESSLILKASEQ :.. ...::. :. . :.: ::: :: ::. : : .. ... XP_011 TQNFHLEVGLIILSVVFAVCLLACLLGVALRKFKRRNQERLNPRDVEYGTIEGLI-TTNV 120 130 140 150 160 170 170 180 190 200 210 220 pF1KE0 GDSMLGDLLDSDCTTGSGSGLPFLVQRTVARQVALVECVGKGRYGEVWRGLWHGESVAVK ::: :.:::: .::.:::::::::::::::::..:.:::::::::::::: :.::.:::: XP_011 GDSTLADLLDHSCTSGSGSGLPFLVQRTVARQITLLECVGKGRYGEVWRGSWQGENVAVK 180 190 200 210 220 230 230 240 250 260 270 280 pF1KE0 IFSSRDEQSWFRETEIYNTVLLRHDNILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFL :::::::.:::::::.::::.:::.:::::::::::::.::::::::::::: :::::.: XP_011 IFSSRDEKSWFRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYL 240 250 260 270 280 290 290 300 310 320 330 340 pF1KE0 QRQTLEPHLALRLAVSAACGLAHLHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADL : ::. ::...: : ::::::.:::::::::::::::.::.:.:::.: ::::::: XP_011 QLTTLDTVSCLRIVLSIASGLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADL 300 310 320 330 340 350 350 360 370 380 390 400 pF1KE0 GLAVMHSQGSDYLDIGNNPRVGTKRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIA ::::::::... ::.::::::::::::::::::: :..:::.::: .:::::::::::.: XP_011 GLAVMHSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVA 360 370 380 390 400 410 410 420 430 440 450 460 pF1KE0 RRTIVNGIVEDYRPPFYDVVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMR :: . :::::::.::::::::::::::::.:::::::: :.:::: .::.:..::..:. XP_011 RRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMK 420 430 440 450 460 470 470 480 490 500 pF1KE0 ECWYPNPSARLTALRIKKTLQKISNSPEKPKVIQ :::: ::::::::::::::: ::.:: .: : XP_011 ECWYQNPSARLTALRIKKTLTKIDNSLDKLKTDC 480 490 500 >>NP_001096 (OMIM: 102576,135100) activin receptor type- (509 aa) initn: 1898 init1: 1832 opt: 1985 Z-score: 811.5 bits: 159.7 E(85289): 1.8e-38 Smith-Waterman score: 1985; 61.1% identity (79.2% similar) in 501 aa overlap (11-500:10-506) 10 20 30 40 50 pF1KE0 MTLGSPRKGLLMLLMALVTQG-DPVKPSRGP-LVTCTCESPHCKGPT-CRGAWCTVVLVR .....:: . . . ::. .: : :.::. : . :.: : : NP_001 MVDGVMILPVLIMIALPSPSMEDEKPKVNPKLYMCVCEGLSCGNEDHCEGQQCFSSLSI 10 20 30 40 50 60 70 80 90 100 110 pF1KE0 EEGRHPQEHRGCGNLHRE---LCRGRPTEFVNHYCCDSHLCNHNVSLVLEATQPPSEQPG ..: : . .:: ..... :. :. ::.. ::.:.. : :. : :: NP_001 NDGFHVYQ-KGCFQVYEQGKMTCKTPPSPGQAVECCQGDWCNRNITAQLP-TKGKSF-PG 60 70 80 90 100 110 120 130 140 150 160 pF1KE0 TDG---QLALILGPVLALLALVA--LGVLGLWHVRRRQEKQRGLHSELGESSLILKASEQ :.. ...::. :. . :.: ::: :: ::. : : .. ... NP_001 TQNFHLEVGLIILSVVFAVCLLACLLGVALRKFKRRNQERLNPRDVEYGTIEGLI-TTNV 120 130 140 150 160 170 170 180 190 200 210 220 pF1KE0 GDSMLGDLLDSDCTTGSGSGLPFLVQRTVARQVALVECVGKGRYGEVWRGLWHGESVAVK ::: :.:::: .::.:::::::::::::::::..:.:::::::::::::: :.::.:::: NP_001 GDSTLADLLDHSCTSGSGSGLPFLVQRTVARQITLLECVGKGRYGEVWRGSWQGENVAVK 180 190 200 210 220 230 230 240 250 260 270 280 pF1KE0 IFSSRDEQSWFRETEIYNTVLLRHDNILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFL :::::::.:::::::.::::.:::.:::::::::::::.::::::::::::: :::::.: NP_001 IFSSRDEKSWFRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYL 240 250 260 270 280 290 290 300 310 320 330 340 pF1KE0 QRQTLEPHLALRLAVSAACGLAHLHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADL : ::. ::...: : ::::::.:::::::::::::::.::.:.:::.: ::::::: NP_001 QLTTLDTVSCLRIVLSIASGLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADL 300 310 320 330 340 350 350 360 370 380 390 400 pF1KE0 GLAVMHSQGSDYLDIGNNPRVGTKRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIA ::::::::... ::.::::::::::::::::::: :..:::.::: .:::::::::::.: NP_001 GLAVMHSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVA 360 370 380 390 400 410 410 420 430 440 450 460 pF1KE0 RRTIVNGIVEDYRPPFYDVVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMR :: . :::::::.::::::::::::::::.:::::::: :.:::: .::.:..::..:. NP_001 RRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMK 420 430 440 450 460 470 470 480 490 500 pF1KE0 ECWYPNPSARLTALRIKKTLQKISNSPEKPKVIQ :::: ::::::::::::::: ::.:: .: : NP_001 ECWYQNPSARLTALRIKKTLTKIDNSLDKLKTDC 480 490 500 503 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 05:06:32 2016 done: Sun Nov 6 05:06:34 2016 Total Scan time: 9.980 Total Display time: 0.110 Function used was FASTA [36.3.4 Apr, 2011]