FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE6253, 214 aa 1>>>pF1KE6253 214 - 214 aa - 214 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.5495+/-0.000326; mu= 18.1823+/- 0.020 mean_var=59.1444+/-11.917, 0's: 0 Z-trim(115.0): 42 B-trim: 738 in 1/53 Lambda= 0.166770 statistics sampled from 25057 (25102) to 25057 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.672), E-opt: 0.2 (0.294), width: 16 Scan time: 5.980 The best scores are: opt bits E(85289) NP_006129 (OMIM: 606498) membrane-spanning 4-domai ( 214) 1418 349.0 3.4e-96 XP_011543665 (OMIM: 606498) PREDICTED: membrane-sp ( 154) 1032 256.0 2.4e-68 NP_001026979 (OMIM: 606498) membrane-spanning 4-do ( 168) 757 189.9 2.1e-48 NP_001026836 (OMIM: 606498) membrane-spanning 4-do ( 91) 587 148.8 2.7e-36 XP_016873398 (OMIM: 606547) PREDICTED: membrane-sp ( 220) 315 83.6 2.7e-16 NP_076926 (OMIM: 606547) membrane-spanning 4-domai ( 220) 315 83.6 2.7e-16 NP_683876 (OMIM: 606547) membrane-spanning 4-domai ( 239) 315 83.7 2.9e-16 NP_076434 (OMIM: 606499) membrane-spanning 4-domai ( 200) 260 70.4 2.4e-12 NP_000130 (OMIM: 147050,147138) high affinity immu ( 244) 250 68.0 1.5e-11 XP_011543152 (OMIM: 147050,147138) PREDICTED: high ( 244) 250 68.0 1.5e-11 XP_005273903 (OMIM: 147050,147138) PREDICTED: high ( 251) 250 68.0 1.5e-11 NP_113645 (OMIM: 606549) membrane-spanning 4-domai ( 250) 245 66.8 3.5e-11 NP_060186 (OMIM: 606550) membrane-spanning 4-domai ( 267) 225 62.0 1e-09 XP_011543419 (OMIM: 606550) PREDICTED: membrane-sp ( 267) 225 62.0 1e-09 XP_016872851 (OMIM: 147050,147138) PREDICTED: high ( 204) 213 59.1 6.2e-09 NP_690590 (OMIM: 606548) membrane-spanning 4-domai ( 178) 199 55.6 5.8e-08 XP_016854968 (OMIM: 608401) PREDICTED: putative me ( 180) 197 55.2 8.1e-08 NP_071744 (OMIM: 606548) membrane-spanning 4-domai ( 225) 198 55.5 8.1e-08 NP_690591 (OMIM: 606548) membrane-spanning 4-domai ( 248) 198 55.5 8.8e-08 NP_001234928 (OMIM: 606548) membrane-spanning 4-do ( 253) 198 55.5 8.9e-08 NP_001317204 (OMIM: 606548) membrane-spanning 4-do ( 276) 198 55.6 9.5e-08 XP_005274234 (OMIM: 606548) PREDICTED: membrane-sp ( 276) 198 55.6 9.5e-08 XP_011506612 (OMIM: 608401) PREDICTED: putative me ( 229) 197 55.3 9.7e-08 XP_016874130 (OMIM: 608401) PREDICTED: putative me ( 180) 191 53.7 2.2e-07 XP_011543718 (OMIM: 608401) PREDICTED: putative me ( 229) 191 53.8 2.6e-07 NP_996822 (OMIM: 606502) membrane-spanning 4-domai ( 240) 189 53.3 3.8e-07 NP_067024 (OMIM: 606502) membrane-spanning 4-domai ( 240) 189 53.3 3.8e-07 NP_001230195 (OMIM: 606547) membrane-spanning 4-do ( 186) 167 48.0 1.2e-05 XP_016873614 (OMIM: 606548) PREDICTED: membrane-sp ( 145) 149 43.5 0.00021 XP_011543511 (OMIM: 606548) PREDICTED: membrane-sp ( 148) 149 43.6 0.00021 NP_690605 (OMIM: 112210,613495) B-lymphocyte antig ( 297) 137 40.9 0.0026 NP_068769 (OMIM: 112210,613495) B-lymphocyte antig ( 297) 137 40.9 0.0026 >>NP_006129 (OMIM: 606498) membrane-spanning 4-domains s (214 aa) initn: 1418 init1: 1418 opt: 1418 Z-score: 1848.0 bits: 349.0 E(85289): 3.4e-96 Smith-Waterman score: 1418; 100.0% identity (100.0% similar) in 214 aa overlap (1-214:1-214) 10 20 30 40 50 60 pF1KE6 MASHEVDNAELGSASAHGTPGSEAGPEELNTSVYQPIDGSPDYQKAKLQVLGAIQILNAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 MASHEVDNAELGSASAHGTPGSEAGPEELNTSVYQPIDGSPDYQKAKLQVLGAIQILNAA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 MILALGVFLGSLQYPYHFQKHFFFFTFYTGYPIWGAVFFCSSGTLSVVAGIKPTRTWIQN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 MILALGVFLGSLQYPYHFQKHFFFFTFYTGYPIWGAVFFCSSGTLSVVAGIKPTRTWIQN 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 SFGMNIASATIALVGTAFLSLNIAVNIQSLRSCHSSSESPDLCNYMGSISNGMVSLLLIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 SFGMNIASATIALVGTAFLSLNIAVNIQSLRSCHSSSESPDLCNYMGSISNGMVSLLLIL 130 140 150 160 170 180 190 200 210 pF1KE6 TLLELCVTISTIAMWCNANCCNSREEISSPPNSV :::::::::::::::::::::::::::::::::: NP_006 TLLELCVTISTIAMWCNANCCNSREEISSPPNSV 190 200 210 >>XP_011543665 (OMIM: 606498) PREDICTED: membrane-spanni (154 aa) initn: 1032 init1: 1032 opt: 1032 Z-score: 1348.0 bits: 256.0 E(85289): 2.4e-68 Smith-Waterman score: 1032; 100.0% identity (100.0% similar) in 154 aa overlap (61-214:1-154) 40 50 60 70 80 90 pF1KE6 TSVYQPIDGSPDYQKAKLQVLGAIQILNAAMILALGVFLGSLQYPYHFQKHFFFFTFYTG :::::::::::::::::::::::::::::: XP_011 MILALGVFLGSLQYPYHFQKHFFFFTFYTG 10 20 30 100 110 120 130 140 150 pF1KE6 YPIWGAVFFCSSGTLSVVAGIKPTRTWIQNSFGMNIASATIALVGTAFLSLNIAVNIQSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YPIWGAVFFCSSGTLSVVAGIKPTRTWIQNSFGMNIASATIALVGTAFLSLNIAVNIQSL 40 50 60 70 80 90 160 170 180 190 200 210 pF1KE6 RSCHSSSESPDLCNYMGSISNGMVSLLLILTLLELCVTISTIAMWCNANCCNSREEISSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RSCHSSSESPDLCNYMGSISNGMVSLLLILTLLELCVTISTIAMWCNANCCNSREEISSP 100 110 120 130 140 150 pF1KE6 PNSV :::: XP_011 PNSV >>NP_001026979 (OMIM: 606498) membrane-spanning 4-domain (168 aa) initn: 1085 init1: 757 opt: 757 Z-score: 989.9 bits: 189.9 E(85289): 2.1e-48 Smith-Waterman score: 997; 78.5% identity (78.5% similar) in 214 aa overlap (1-214:1-168) 10 20 30 40 50 60 pF1KE6 MASHEVDNAELGSASAHGTPGSEAGPEELNTSVYQPIDGSPDYQKAKLQVLGAIQILNAA :::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MASHEVDNAELGSASAHGTPGSEAGPEELNTSVYQPIDGSPDYQKAKLQVLG-------- 10 20 30 40 50 70 80 90 100 110 120 pF1KE6 MILALGVFLGSLQYPYHFQKHFFFFTFYTGYPIWGAVFFCSSGTLSVVAGIKPTRTWIQN :::::::::::::::::::::: NP_001 --------------------------------------FCSSGTLSVVAGIKPTRTWIQN 60 70 130 140 150 160 170 180 pF1KE6 SFGMNIASATIALVGTAFLSLNIAVNIQSLRSCHSSSESPDLCNYMGSISNGMVSLLLIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SFGMNIASATIALVGTAFLSLNIAVNIQSLRSCHSSSESPDLCNYMGSISNGMVSLLLIL 80 90 100 110 120 130 190 200 210 pF1KE6 TLLELCVTISTIAMWCNANCCNSREEISSPPNSV :::::::::::::::::::::::::::::::::: NP_001 TLLELCVTISTIAMWCNANCCNSREEISSPPNSV 140 150 160 >>NP_001026836 (OMIM: 606498) membrane-spanning 4-domain (91 aa) initn: 587 init1: 587 opt: 587 Z-score: 772.5 bits: 148.8 E(85289): 2.7e-36 Smith-Waterman score: 587; 100.0% identity (100.0% similar) in 91 aa overlap (124-214:1-91) 100 110 120 130 140 150 pF1KE6 WGAVFFCSSGTLSVVAGIKPTRTWIQNSFGMNIASATIALVGTAFLSLNIAVNIQSLRSC :::::::::::::::::::::::::::::: NP_001 MNIASATIALVGTAFLSLNIAVNIQSLRSC 10 20 30 160 170 180 190 200 210 pF1KE6 HSSSESPDLCNYMGSISNGMVSLLLILTLLELCVTISTIAMWCNANCCNSREEISSPPNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HSSSESPDLCNYMGSISNGMVSLLLILTLLELCVTISTIAMWCNANCCNSREEISSPPNS 40 50 60 70 80 90 pF1KE6 V : NP_001 V >>XP_016873398 (OMIM: 606547) PREDICTED: membrane-spanni (220 aa) initn: 349 init1: 172 opt: 315 Z-score: 413.6 bits: 83.6 E(85289): 2.7e-16 Smith-Waterman score: 315; 31.7% identity (64.5% similar) in 186 aa overlap (20-201:12-193) 10 20 30 40 50 pF1KE6 MASHEVDNAELGSASAHGTPGSEAG-PEELNTSVYQP--IDGSPD-YQKAKLQVLGAIQI ::. : :. : .: . : . . :.. .:::..:: XP_016 MTTMQGMEQAMPGAGPGVPQLGNMAVIHSHLWKGLQEKFLKGEPKVLGVVQI 10 20 30 40 50 60 70 80 90 100 110 pF1KE6 LNAAMILALGVFLGSLQYPYHFQKHFFFFTFYTGYPIWGAVFFCSSGTLSVVAGIKPTRT :.: : :..:. . . . .. .. : :: :::.:.: ::.::..:::. :. XP_016 LTALMSLSMGITMMCMASNTYGSNP---ISVYIGYTIWGSVMFIISGSLSIAAGIRTTKG 60 70 80 90 100 120 130 140 150 160 170 pF1KE6 WIQNSFGMNIASATIALVGTAFLSLNIAVNIQSLRSCHSSSESPDLCNYMGSISNGMVSL ...:.::::.:...: : . ....: :. ..: . :. :: :. .. XP_016 LVRGSLGMNITSSVLAASGILINTFSLAFYSFHHPYCNYYGNSNN-CHGTMSILMGLDGM 110 120 130 140 150 160 180 190 200 210 pF1KE6 LLILTLLELCVTISTIAMWCNANCCNSREEISSPPNSV .:.:..::.:...: :. :.. :: XP_016 VLLLSVLEFCIAVSLSAFGCKVLCCTPGGVVLILPSHSHMAETASPTPLNEV 170 180 190 200 210 220 >>NP_076926 (OMIM: 606547) membrane-spanning 4-domains s (220 aa) initn: 349 init1: 172 opt: 315 Z-score: 413.6 bits: 83.6 E(85289): 2.7e-16 Smith-Waterman score: 315; 31.7% identity (64.5% similar) in 186 aa overlap (20-201:12-193) 10 20 30 40 50 pF1KE6 MASHEVDNAELGSASAHGTPGSEAG-PEELNTSVYQP--IDGSPD-YQKAKLQVLGAIQI ::. : :. : .: . : . . :.. .:::..:: NP_076 MTTMQGMEQAMPGAGPGVPQLGNMAVIHSHLWKGLQEKFLKGEPKVLGVVQI 10 20 30 40 50 60 70 80 90 100 110 pF1KE6 LNAAMILALGVFLGSLQYPYHFQKHFFFFTFYTGYPIWGAVFFCSSGTLSVVAGIKPTRT :.: : :..:. . . . .. .. : :: :::.:.: ::.::..:::. :. NP_076 LTALMSLSMGITMMCMASNTYGSNP---ISVYIGYTIWGSVMFIISGSLSIAAGIRTTKG 60 70 80 90 100 120 130 140 150 160 170 pF1KE6 WIQNSFGMNIASATIALVGTAFLSLNIAVNIQSLRSCHSSSESPDLCNYMGSISNGMVSL ...:.::::.:...: : . ....: :. ..: . :. :: :. .. NP_076 LVRGSLGMNITSSVLAASGILINTFSLAFYSFHHPYCNYYGNSNN-CHGTMSILMGLDGM 110 120 130 140 150 160 180 190 200 210 pF1KE6 LLILTLLELCVTISTIAMWCNANCCNSREEISSPPNSV .:.:..::.:...: :. :.. :: NP_076 VLLLSVLEFCIAVSLSAFGCKVLCCTPGGVVLILPSHSHMAETASPTPLNEV 170 180 190 200 210 220 >>NP_683876 (OMIM: 606547) membrane-spanning 4-domains s (239 aa) initn: 349 init1: 172 opt: 315 Z-score: 413.1 bits: 83.7 E(85289): 2.9e-16 Smith-Waterman score: 315; 31.7% identity (64.5% similar) in 186 aa overlap (20-201:31-212) 10 20 30 40 pF1KE6 MASHEVDNAELGSASAHGTPGSEAG-PEELNTSVYQP--IDGSPD-YQK ::. : :. : .: . : . . : NP_683 MHQTYSRHCRPEESTFSAAMTTMQGMEQAMPGAGPGVPQLGNMAVIHSHLWKGLQEKFLK 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE6 AKLQVLGAIQILNAAMILALGVFLGSLQYPYHFQKHFFFFTFYTGYPIWGAVFFCSSGTL .. .:::..:::.: : :..:. . . . .. .. : :: :::.:.: ::.: NP_683 GEPKVLGVVQILTALMSLSMGITMMCMASNTYGSNP---ISVYIGYTIWGSVMFIISGSL 70 80 90 100 110 110 120 130 140 150 160 pF1KE6 SVVAGIKPTRTWIQNSFGMNIASATIALVGTAFLSLNIAVNIQSLRSCHSSSESPDLCNY :..:::. :. ...:.::::.:...: : . ....: :. ..: . :. NP_683 SIAAGIRTTKGLVRGSLGMNITSSVLAASGILINTFSLAFYSFHHPYCNYYGNSNN-CHG 120 130 140 150 160 170 170 180 190 200 210 pF1KE6 MGSISNGMVSLLLILTLLELCVTISTIAMWCNANCCNSREEISSPPNSV :: :. ...:.:..::.:...: :. :.. :: NP_683 TMSILMGLDGMVLLLSVLEFCIAVSLSAFGCKVLCCTPGGVVLILPSHSHMAETASPTPL 180 190 200 210 220 230 NP_683 NEV >>NP_076434 (OMIM: 606499) membrane-spanning 4-domains s (200 aa) initn: 198 init1: 123 opt: 260 Z-score: 342.6 bits: 70.4 E(85289): 2.4e-12 Smith-Waterman score: 260; 28.6% identity (60.2% similar) in 206 aa overlap (11-205:1-198) 10 20 30 40 50 pF1KE6 MASHEVDNAELGSASAHGTPGSEAGPEELNTSVYQPIDGSPD-------YQKA---KLQV . :..:: .: . : :...: :. . : :: :... NP_076 MDSSTAH-SPVFLVFPPEITASEYESTELSATTFSTQSPLQKLFARKMKI 10 20 30 40 60 70 80 90 100 pF1KE6 LGAIQILNAAMILALGV-FLGSLQYPYHFQKHFFFFTFYTGYPIWGAVFFCSSGTLSVVA ::.:::: . : ...:: :: .: :: : : : .:::.::.:.: .::.. ... NP_076 LGTIQILFGIMTFSFGVIFLFTLLKPYPR----FPFIFLSGYPFWGSVLFINSGAFLIAV 50 60 70 80 90 100 110 120 130 140 150 160 pF1KE6 GIKPTRTWIQNSFGMNIASATIALVGTAFLSLNIAVNIQSLRSCHSSSESPDLCNYMGSI : :.: : : ::. :: :..: .:.... .. . . : : .. . :. . . NP_076 KRKTTETLIILSRIMNFLSALGAIAGIILLTFGFILDQNYI--CGYSHQNSQ-CKAVTVL 110 120 130 140 150 160 170 180 190 200 210 pF1KE6 SNGMVSLLLILTLLELCVTISTIAMWCNANCCNSREEISSPPNSV :.. :. ....:: ... . :... :. .. NP_076 FLGILITLMTFSIIELFISLPFSILGCHSEDCDCEQCC 170 180 190 200 >>NP_000130 (OMIM: 147050,147138) high affinity immunogl (244 aa) initn: 187 init1: 152 opt: 250 Z-score: 328.4 bits: 68.0 E(85289): 1.5e-11 Smith-Waterman score: 250; 29.3% identity (61.4% similar) in 184 aa overlap (23-198:27-204) 10 20 30 40 50 pF1KE6 MASHEVDNAELGSASAHGTPGSEAGPEELNTSVYQPIDGSPDYQ------KAKLQV : .:.:.... .:: . : . . NP_000 MDTESNRRANLALPQEPSSVPAFEVLEISPQEVSSGRLLKSASSPPLHTWLTVLKKEQEF 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE6 LGAIQILNAAMILALGVFLGSLQYPYHFQKHFFFFTFYTGYPIWGAVFFCSSGTLSVVAG ::. :::.: . : .:. . :. :.. .: .: .:::.:::.:: :: ::... NP_000 LGVTQILTAMICLCFGTVVCSVLDISHIEGDIFS-SFKAGYPFWGAIFFSISGMLSIISE 70 80 90 100 110 120 130 140 150 160 pF1KE6 IKPTRTWIQNSFGMNIASATIALVGTAFLSLNIAVNIQ--SLRSCHSSSESPDLCNYMGS . . ...:.: : ::. . .: ..: .:. .. ..::.. :. : .:.: NP_000 RRNATYLVRGSLGANTASSIAGGTGITILIINLKKSLAYIHIHSCQKFFETK--C-FMAS 120 130 140 150 160 170 170 180 190 200 210 pF1KE6 ISNGMVSLLLILTLLELCVTISTIAMWCNANCCNSREEISSPPNSV .:. .: ..:.::.: : ..: :.: NP_000 FSTEIVVMMLFLTILGLGSAVSLTI--CGAGEELKGNKVPEDRVYEELNIYSATYSELED 180 190 200 210 220 230 >>XP_011543152 (OMIM: 147050,147138) PREDICTED: high aff (244 aa) initn: 187 init1: 152 opt: 250 Z-score: 328.4 bits: 68.0 E(85289): 1.5e-11 Smith-Waterman score: 250; 29.3% identity (61.4% similar) in 184 aa overlap (23-198:27-204) 10 20 30 40 50 pF1KE6 MASHEVDNAELGSASAHGTPGSEAGPEELNTSVYQPIDGSPDYQ------KAKLQV : .:.:.... .:: . : . . XP_011 MDTESNRRANLALPQEPSSVPAFEVLEISPQEVSSGRLLKSASSPPLHTWLTVLKKEQEF 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE6 LGAIQILNAAMILALGVFLGSLQYPYHFQKHFFFFTFYTGYPIWGAVFFCSSGTLSVVAG ::. :::.: . : .:. . :. :.. .: .: .:::.:::.:: :: ::... XP_011 LGVTQILTAMICLCFGTVVCSVLDISHIEGDIFS-SFKAGYPFWGAIFFSISGMLSIISE 70 80 90 100 110 120 130 140 150 160 pF1KE6 IKPTRTWIQNSFGMNIASATIALVGTAFLSLNIAVNIQ--SLRSCHSSSESPDLCNYMGS . . ...:.: : ::. . .: ..: .:. .. ..::.. :. : .:.: XP_011 RRNATYLVRGSLGANTASSIAGGTGITILIINLKKSLAYIHIHSCQKFFETK--C-FMAS 120 130 140 150 160 170 170 180 190 200 210 pF1KE6 ISNGMVSLLLILTLLELCVTISTIAMWCNANCCNSREEISSPPNSV .:. .: ..:.::.: : ..: :.: XP_011 FSTEIVVMMLFLTILGLGSAVSLTI--CGAGEELKGNKVPEDRVYEELNIYSATYSELED 180 190 200 210 220 230 214 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 11:29:33 2016 done: Tue Nov 8 11:29:34 2016 Total Scan time: 5.980 Total Display time: 0.000 Function used was FASTA [36.3.4 Apr, 2011]