FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE3035, 168 aa 1>>>pF1KE3035 168 - 168 aa - 168 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.0638+/-0.000308; mu= 13.9457+/- 0.019 mean_var=68.4101+/-13.787, 0's: 0 Z-trim(117.8): 47 B-trim: 548 in 1/51 Lambda= 0.155065 statistics sampled from 30083 (30134) to 30083 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.751), E-opt: 0.2 (0.353), width: 16 Scan time: 5.100 The best scores are: opt bits E(85289) NP_071914 (OMIM: 608832) gremlin-2 precursor [Homo ( 168) 1150 265.5 2.9e-71 XP_011542551 (OMIM: 608832) PREDICTED: gremlin-2 i ( 168) 1150 265.5 2.9e-71 XP_005273283 (OMIM: 608832) PREDICTED: gremlin-2 i ( 186) 1150 265.5 3.2e-71 NP_037504 (OMIM: 603054) gremlin-1 isoform 1 precu ( 184) 622 147.4 1.1e-35 XP_016877566 (OMIM: 603054) PREDICTED: gremlin-1 i ( 221) 622 147.4 1.3e-35 XP_005254358 (OMIM: 603054) PREDICTED: gremlin-1 i ( 240) 622 147.5 1.4e-35 NP_001178251 (OMIM: 603054) gremlin-1 isoform 3 [H ( 114) 576 136.9 9.8e-33 NP_001178252 (OMIM: 603054) gremlin-1 isoform 2 pr ( 143) 577 137.2 1e-32 NP_001191013 (OMIM: 600613) neuroblastoma suppress ( 181) 249 63.9 1.5e-10 NP_001191014 (OMIM: 600613) neuroblastoma suppress ( 181) 249 63.9 1.5e-10 NP_001265095 (OMIM: 600613) neuroblastoma suppress ( 181) 249 63.9 1.5e-10 NP_005371 (OMIM: 600613) neuroblastoma suppressor ( 181) 249 63.9 1.5e-10 NP_001265094 (OMIM: 600613) neuroblastoma suppress ( 181) 249 63.9 1.5e-10 NP_001265093 (OMIM: 600613) neuroblastoma suppress ( 181) 249 63.9 1.5e-10 NP_001191015 (OMIM: 600613) neuroblastoma suppress ( 215) 249 64.0 1.7e-10 NP_877421 (OMIM: 600613) neuroblastoma suppressor ( 216) 249 64.0 1.7e-10 NP_005445 (OMIM: 603777) cerberus precursor [Homo ( 267) 224 58.4 9.7e-09 NP_689867 (OMIM: 609068) DAN domain family member ( 189) 156 43.1 0.00028 NP_079513 (OMIM: 122860,239100,269500,605740) scle ( 213) 143 40.3 0.0023 NP_002448 (OMIM: 158370) mucin-2 precursor [Homo s (5289) 152 43.3 0.0072 >>NP_071914 (OMIM: 608832) gremlin-2 precursor [Homo sap (168 aa) initn: 1150 init1: 1150 opt: 1150 Z-score: 1400.3 bits: 265.5 E(85289): 2.9e-71 Smith-Waterman score: 1150; 100.0% identity (100.0% similar) in 168 aa overlap (1-168:1-168) 10 20 30 40 50 60 pF1KE3 MFWKLSLSLFLVAVLVKVAEARKNRPAGAIPSPYKDGSSNNSERWQHQIKEVLASSQEAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_071 MFWKLSLSLFLVAVLVKVAEARKNRPAGAIPSPYKDGSSNNSERWQHQIKEVLASSQEAL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 VVTERKYLKSDWCKTQPLRQTVSEEGCRSRTILNRFCYGQCNSFYIPRHVKKEEESFQSC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_071 VVTERKYLKSDWCKTQPLRQTVSEEGCRSRTILNRFCYGQCNSFYIPRHVKKEEESFQSC 70 80 90 100 110 120 130 140 150 160 pF1KE3 AFCKPQRVTSVLVELECPGLDPPFRLKKIQKVKQCRCMSVNLSDSDKQ :::::::::::::::::::::::::::::::::::::::::::::::: NP_071 AFCKPQRVTSVLVELECPGLDPPFRLKKIQKVKQCRCMSVNLSDSDKQ 130 140 150 160 >>XP_011542551 (OMIM: 608832) PREDICTED: gremlin-2 isofo (168 aa) initn: 1150 init1: 1150 opt: 1150 Z-score: 1400.3 bits: 265.5 E(85289): 2.9e-71 Smith-Waterman score: 1150; 100.0% identity (100.0% similar) in 168 aa overlap (1-168:1-168) 10 20 30 40 50 60 pF1KE3 MFWKLSLSLFLVAVLVKVAEARKNRPAGAIPSPYKDGSSNNSERWQHQIKEVLASSQEAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MFWKLSLSLFLVAVLVKVAEARKNRPAGAIPSPYKDGSSNNSERWQHQIKEVLASSQEAL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 VVTERKYLKSDWCKTQPLRQTVSEEGCRSRTILNRFCYGQCNSFYIPRHVKKEEESFQSC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VVTERKYLKSDWCKTQPLRQTVSEEGCRSRTILNRFCYGQCNSFYIPRHVKKEEESFQSC 70 80 90 100 110 120 130 140 150 160 pF1KE3 AFCKPQRVTSVLVELECPGLDPPFRLKKIQKVKQCRCMSVNLSDSDKQ :::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AFCKPQRVTSVLVELECPGLDPPFRLKKIQKVKQCRCMSVNLSDSDKQ 130 140 150 160 >>XP_005273283 (OMIM: 608832) PREDICTED: gremlin-2 isofo (186 aa) initn: 1150 init1: 1150 opt: 1150 Z-score: 1399.7 bits: 265.5 E(85289): 3.2e-71 Smith-Waterman score: 1150; 100.0% identity (100.0% similar) in 168 aa overlap (1-168:19-186) 10 20 30 40 pF1KE3 MFWKLSLSLFLVAVLVKVAEARKNRPAGAIPSPYKDGSSNNS :::::::::::::::::::::::::::::::::::::::::: XP_005 MRALRAESTSGSRQTPCRMFWKLSLSLFLVAVLVKVAEARKNRPAGAIPSPYKDGSSNNS 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE3 ERWQHQIKEVLASSQEALVVTERKYLKSDWCKTQPLRQTVSEEGCRSRTILNRFCYGQCN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ERWQHQIKEVLASSQEALVVTERKYLKSDWCKTQPLRQTVSEEGCRSRTILNRFCYGQCN 70 80 90 100 110 120 110 120 130 140 150 160 pF1KE3 SFYIPRHVKKEEESFQSCAFCKPQRVTSVLVELECPGLDPPFRLKKIQKVKQCRCMSVNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SFYIPRHVKKEEESFQSCAFCKPQRVTSVLVELECPGLDPPFRLKKIQKVKQCRCMSVNL 130 140 150 160 170 180 pF1KE3 SDSDKQ :::::: XP_005 SDSDKQ >>NP_037504 (OMIM: 603054) gremlin-1 isoform 1 precursor (184 aa) initn: 675 init1: 614 opt: 622 Z-score: 761.3 bits: 147.4 E(85289): 1.1e-35 Smith-Waterman score: 647; 55.5% identity (75.1% similar) in 173 aa overlap (9-162:12-183) 10 20 30 40 50 pF1KE3 MFWKLSLSLFLVAVLVKVAEARKNRPAGAIPSPYKDGSSNNSERWQHQIK------- :.:...:. .::..:. :::: : : .. :.::. : . NP_037 MSRTAYTVGALLLLLGTLLPAAEGKKKGSQGAIPPPDK-AQHNDSEQTQSPQQPGSRNRG 10 20 30 40 50 60 70 80 90 pF1KE3 ------------EVLASSQEALVVTERKYLKSDWCKTQPLRQTVSEEGCRSRTILNRFCY ::: :::::: :::::::: ::::::::.::. :::: ::::.::::: NP_037 RGQGRGTAMPGEEVLESSQEALHVTERKYLKRDWCKTQPLKQTIHEEGCNSRTIINRFCY 60 70 80 90 100 110 100 110 120 130 140 150 pF1KE3 GQCNSFYIPRHVKKEEESFQSCAFCKPQRVTSVLVELECPGLDPPFRLKKIQKVKQCRCM :::::::::::..::: :::::.::::.. :...: :.:: :.:: . :.. .::::::. NP_037 GQCNSFYIPRHIRKEEGSFQSCSFCKPKKFTTMMVTLNCPELQPPTKKKRVTRVKQCRCI 120 130 140 150 160 170 160 pF1KE3 SVNLSDSDKQ :..: NP_037 SIDLD 180 >>XP_016877566 (OMIM: 603054) PREDICTED: gremlin-1 isofo (221 aa) initn: 675 init1: 614 opt: 622 Z-score: 760.2 bits: 147.4 E(85289): 1.3e-35 Smith-Waterman score: 647; 55.5% identity (75.1% similar) in 173 aa overlap (9-162:49-220) 10 20 30 pF1KE3 MFWKLSLSLFLVAVLVKVAEARKNRPAGAIPSPYKDGS :.:...:. .::..:. :::: : : .. XP_016 SAGWSIRRIHDVCICRSPSMSRTAYTVGALLLLLGTLLPAAEGKKKGSQGAIPPPDK-AQ 20 30 40 50 60 70 40 50 60 70 pF1KE3 SNNSERWQHQIK-------------------EVLASSQEALVVTERKYLKSDWCKTQPLR :.::. : . ::: :::::: :::::::: ::::::::. XP_016 HNDSEQTQSPQQPGSRNRGRGQGRGTAMPGEEVLESSQEALHVTERKYLKRDWCKTQPLK 80 90 100 110 120 130 80 90 100 110 120 130 pF1KE3 QTVSEEGCRSRTILNRFCYGQCNSFYIPRHVKKEEESFQSCAFCKPQRVTSVLVELECPG ::. :::: ::::.::::::::::::::::..::: :::::.::::.. :...: :.:: XP_016 QTIHEEGCNSRTIINRFCYGQCNSFYIPRHIRKEEGSFQSCSFCKPKKFTTMMVTLNCPE 140 150 160 170 180 190 140 150 160 pF1KE3 LDPPFRLKKIQKVKQCRCMSVNLSDSDKQ :.:: . :.. .::::::.:..: XP_016 LQPPTKKKRVTRVKQCRCISIDLD 200 210 220 >>XP_005254358 (OMIM: 603054) PREDICTED: gremlin-1 isofo (240 aa) initn: 698 init1: 614 opt: 622 Z-score: 759.7 bits: 147.5 E(85289): 1.4e-35 Smith-Waterman score: 647; 55.5% identity (75.1% similar) in 173 aa overlap (9-162:68-239) 10 20 30 pF1KE3 MFWKLSLSLFLVAVLVKVAEARKNRPAGAIPSPYKDGS :.:...:. .::..:. :::: : : .. XP_005 RTQRHASKAQAPRTRRTDSMSRTAYTVGALLLLLGTLLPAAEGKKKGSQGAIPPPDK-AQ 40 50 60 70 80 90 40 50 60 70 pF1KE3 SNNSERWQHQIK-------------------EVLASSQEALVVTERKYLKSDWCKTQPLR :.::. : . ::: :::::: :::::::: ::::::::. XP_005 HNDSEQTQSPQQPGSRNRGRGQGRGTAMPGEEVLESSQEALHVTERKYLKRDWCKTQPLK 100 110 120 130 140 150 80 90 100 110 120 130 pF1KE3 QTVSEEGCRSRTILNRFCYGQCNSFYIPRHVKKEEESFQSCAFCKPQRVTSVLVELECPG ::. :::: ::::.::::::::::::::::..::: :::::.::::.. :...: :.:: XP_005 QTIHEEGCNSRTIINRFCYGQCNSFYIPRHIRKEEGSFQSCSFCKPKKFTTMMVTLNCPE 160 170 180 190 200 210 140 150 160 pF1KE3 LDPPFRLKKIQKVKQCRCMSVNLSDSDKQ :.:: . :.. .::::::.:..: XP_005 LQPPTKKKRVTRVKQCRCISIDLD 220 230 240 >>NP_001178251 (OMIM: 603054) gremlin-1 isoform 3 [Homo (114 aa) initn: 587 init1: 576 opt: 576 Z-score: 708.7 bits: 136.9 E(85289): 9.8e-33 Smith-Waterman score: 576; 70.2% identity (89.4% similar) in 104 aa overlap (59-162:10-113) 30 40 50 60 70 80 pF1KE3 AIPSPYKDGSSNNSERWQHQIKEVLASSQEALVVTERKYLKSDWCKTQPLRQTVSEEGCR :: :::::::: ::::::::.::. :::: NP_001 MSRTAYTVGALHVTERKYLKRDWCKTQPLKQTIHEEGCN 10 20 30 90 100 110 120 130 140 pF1KE3 SRTILNRFCYGQCNSFYIPRHVKKEEESFQSCAFCKPQRVTSVLVELECPGLDPPFRLKK ::::.::::::::::::::::..::: :::::.::::.. :...: :.:: :.:: . :. NP_001 SRTIINRFCYGQCNSFYIPRHIRKEEGSFQSCSFCKPKKFTTMMVTLNCPELQPPTKKKR 40 50 60 70 80 90 150 160 pF1KE3 IQKVKQCRCMSVNLSDSDKQ . .::::::.:..: NP_001 VTRVKQCRCISIDLD 100 110 >>NP_001178252 (OMIM: 603054) gremlin-1 isoform 2 precur (143 aa) initn: 617 init1: 576 opt: 577 Z-score: 708.5 bits: 137.2 E(85289): 1e-32 Smith-Waterman score: 592; 55.2% identity (74.0% similar) in 154 aa overlap (9-162:12-142) 10 20 30 40 50 pF1KE3 MFWKLSLSLFLVAVLVKVAEARKNRPAGAIPSPYKDGSSNNSERWQHQIKEVLASSQ :.:...:. .::..:. :::: : : NP_001 MSRTAYTVGALLLLLGTLLPAAEGKKKGSQGAIPPPDK---------------------- 10 20 30 60 70 80 90 100 110 pF1KE3 EALVVTERKYLKSDWCKTQPLRQTVSEEGCRSRTILNRFCYGQCNSFYIPRHVKKEEESF :: :::::::: ::::::::.::. :::: ::::.::::::::::::::::..::: :: NP_001 -ALHVTERKYLKRDWCKTQPLKQTIHEEGCNSRTIINRFCYGQCNSFYIPRHIRKEEGSF 40 50 60 70 80 90 120 130 140 150 160 pF1KE3 QSCAFCKPQRVTSVLVELECPGLDPPFRLKKIQKVKQCRCMSVNLSDSDKQ :::.::::.. :...: :.:: :.:: . :.. .::::::.:..: NP_001 QSCSFCKPKKFTTMMVTLNCPELQPPTKKKRVTRVKQCRCISIDLD 100 110 120 130 140 >>NP_001191013 (OMIM: 600613) neuroblastoma suppressor o (181 aa) initn: 231 init1: 217 opt: 249 Z-score: 310.5 bits: 63.9 E(85289): 1.5e-10 Smith-Waterman score: 249; 35.9% identity (62.0% similar) in 92 aa overlap (69-159:31-122) 40 50 60 70 80 90 pF1KE3 SNNSERWQHQIKEVLASSQEALVVTERKYLKSDWCKTQPLRQTVSEEGCRSRTILNRFCY :: ::... . : :.. ::....: :: : NP_001 MMLRVLVGAVLPAMLLAAPPPINKLALFPDKSAWCEAKNITQIVGHSGCEAKSIQNRACL 10 20 30 40 50 60 100 110 120 130 140 150 pF1KE3 GQCNSFYIPRHVKKEEESFQSCAFCKPQRVTSVLVELECPGLDPPFRLKK-IQKVKQCRC ::: :. .: . ::. : : : . .: ::::: . :. : ..:. .: : NP_001 GQCFSYSVPNTFPQSTESLVHCDSCMPAQSMWEIVTLECPGHEEVPRVDKLVEKILHCSC 70 80 90 100 110 120 160 pF1KE3 MSVNLSDSDKQ .. NP_001 QACGKEPSHEGLSVYVQGEDGPGSQPGTHPHPHPHPHPGGQTPEPEDPPGAPHTEEEGAE 130 140 150 160 170 180 >>NP_001191014 (OMIM: 600613) neuroblastoma suppressor o (181 aa) initn: 231 init1: 217 opt: 249 Z-score: 310.5 bits: 63.9 E(85289): 1.5e-10 Smith-Waterman score: 249; 35.9% identity (62.0% similar) in 92 aa overlap (69-159:31-122) 40 50 60 70 80 90 pF1KE3 SNNSERWQHQIKEVLASSQEALVVTERKYLKSDWCKTQPLRQTVSEEGCRSRTILNRFCY :: ::... . : :.. ::....: :: : NP_001 MMLRVLVGAVLPAMLLAAPPPINKLALFPDKSAWCEAKNITQIVGHSGCEAKSIQNRACL 10 20 30 40 50 60 100 110 120 130 140 150 pF1KE3 GQCNSFYIPRHVKKEEESFQSCAFCKPQRVTSVLVELECPGLDPPFRLKK-IQKVKQCRC ::: :. .: . ::. : : : . .: ::::: . :. : ..:. .: : NP_001 GQCFSYSVPNTFPQSTESLVHCDSCMPAQSMWEIVTLECPGHEEVPRVDKLVEKILHCSC 70 80 90 100 110 120 160 pF1KE3 MSVNLSDSDKQ .. NP_001 QACGKEPSHEGLSVYVQGEDGPGSQPGTHPHPHPHPHPGGQTPEPEDPPGAPHTEEEGAE 130 140 150 160 170 180 168 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 12:38:48 2016 done: Sun Nov 6 12:38:49 2016 Total Scan time: 5.100 Total Display time: -0.010 Function used was FASTA [36.3.4 Apr, 2011]