Result of FASTA (omim) for
pFN21AE3818
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE3818, 1182 aa
1>>>pF1KE3818 1182 - 1182 aa - 1182 aa
Library: /omim/omim.rfq.tfa
64369986 residues in 92320 sequences
Statistics: Expectation_n fit: rho(ln(x))= 11.5713+/-0.000529; mu= -4.2278+/- 0.033
mean_var=655.6521+/-145.320, 0's: 0 Z-trim(120.9): 1515 B-trim: 2242 in 1/58
Lambda= 0.050088
statistics sampled from 36103 (38201) to 36103 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.721), E-opt: 0.2 (0.414), width: 16
Scan time: 8.670
The best scores are: opt bits E(92320)
NP_009298 (OMIM: 164690) tyrosine-protein kinase A (1182) 7914 588.8 7.3e-167
NP_005149 (OMIM: 164690) tyrosine-protein kinase A (1167) 7554 562.8 4.9e-159
XP_016856524 (OMIM: 164690) tyrosine-protein kinas (1182) 7409 552.3 7.1e-156
NP_001161708 (OMIM: 164690) tyrosine-protein kinas (1161) 7402 551.8 1e-155
XP_005245145 (OMIM: 164690) tyrosine-protein kinas (1146) 7401 551.7 1e-155
NP_001161709 (OMIM: 164690) tyrosine-protein kinas (1079) 4614 350.3 4.2e-95
NP_001129472 (OMIM: 164690) tyrosine-protein kinas (1064) 4254 324.2 2.9e-87
NP_001161710 (OMIM: 164690) tyrosine-protein kinas (1058) 4102 313.3 5.8e-84
NP_001161711 (OMIM: 164690) tyrosine-protein kinas (1043) 4101 313.2 6e-84
NP_005148 (OMIM: 189980,608232,617602) tyrosine-pr (1130) 3371 260.5 4.8e-68
NP_009297 (OMIM: 189980,608232,617602) tyrosine-pr (1149) 3371 260.5 4.8e-68
NP_001129473 (OMIM: 164690) tyrosine-protein kinas ( 542) 3213 248.6 8.5e-65
NP_694592 (OMIM: 137025) tyrosine-protein kinase F ( 534) 1275 108.6 1.2e-22
XP_016866142 (OMIM: 137025) tyrosine-protein kinas ( 537) 1269 108.1 1.6e-22
XP_016866139 (OMIM: 137025) tyrosine-protein kinas ( 537) 1269 108.1 1.6e-22
NP_002028 (OMIM: 137025) tyrosine-protein kinase F ( 537) 1269 108.1 1.6e-22
NP_001357458 (OMIM: 137025) tyrosine-protein kinas ( 537) 1269 108.1 1.6e-22
XP_016866141 (OMIM: 137025) tyrosine-protein kinas ( 537) 1269 108.1 1.6e-22
XP_016866140 (OMIM: 137025) tyrosine-protein kinas ( 537) 1269 108.1 1.6e-22
NP_005424 (OMIM: 164880) tyrosine-protein kinase Y ( 543) 1259 107.4 2.7e-22
XP_024307011 (OMIM: 164880) tyrosine-protein kinas ( 543) 1259 107.4 2.7e-22
XP_024307013 (OMIM: 164880) tyrosine-protein kinas ( 543) 1259 107.4 2.7e-22
XP_016881449 (OMIM: 164880) tyrosine-protein kinas ( 543) 1259 107.4 2.7e-22
XP_024307014 (OMIM: 164880) tyrosine-protein kinas ( 543) 1259 107.4 2.7e-22
XP_024307012 (OMIM: 164880) tyrosine-protein kinas ( 543) 1259 107.4 2.7e-22
NP_001036212 (OMIM: 164940) tyrosine-protein kinas ( 529) 1256 107.2 3.1e-22
XP_011539312 (OMIM: 164940) tyrosine-protein kinas ( 529) 1256 107.2 3.1e-22
NP_001036194 (OMIM: 164940) tyrosine-protein kinas ( 529) 1256 107.2 3.1e-22
NP_005239 (OMIM: 164940) tyrosine-protein kinase F ( 529) 1256 107.2 3.1e-22
XP_006710515 (OMIM: 164940) tyrosine-protein kinas ( 529) 1256 107.2 3.1e-22
NP_005408 (OMIM: 114500,190090,616937) proto-oncog ( 536) 1251 106.8 4.1e-22
NP_938033 (OMIM: 114500,190090,616937) proto-oncog ( 536) 1251 106.8 4.1e-22
XP_011527315 (OMIM: 114500,190090,616937) proto-on ( 536) 1251 106.8 4.1e-22
NP_005347 (OMIM: 153390,615758) tyrosine-protein k ( 509) 1230 105.3 1.1e-21
NP_001036236 (OMIM: 153390,615758) tyrosine-protei ( 509) 1230 105.3 1.1e-21
XP_024302815 (OMIM: 153390,615758) tyrosine-protei ( 567) 1229 105.3 1.3e-21
XP_024302814 (OMIM: 153390,615758) tyrosine-protei ( 567) 1229 105.3 1.3e-21
NP_001165602 (OMIM: 142370) tyrosine-protein kinas ( 504) 1218 104.4 2e-21
NP_001165601 (OMIM: 142370) tyrosine-protein kinas ( 525) 1218 104.4 2.1e-21
NP_001165604 (OMIM: 142370) tyrosine-protein kinas ( 505) 1216 104.3 2.3e-21
NP_001165600 (OMIM: 142370) tyrosine-protein kinas ( 505) 1216 104.3 2.3e-21
NP_001165603 (OMIM: 142370) tyrosine-protein kinas ( 506) 1216 104.3 2.3e-21
NP_002101 (OMIM: 142370) tyrosine-protein kinase H ( 526) 1216 104.3 2.3e-21
XP_011515831 (OMIM: 165120) tyrosine-protein kinas ( 682) 1208 103.9 4e-21
XP_016866134 (OMIM: 606573) tyrosine-protein kinas ( 505) 1196 102.8 6.2e-21
XP_011533956 (OMIM: 606573) tyrosine-protein kinas ( 505) 1196 102.8 6.2e-21
NP_002022 (OMIM: 606573) tyrosine-protein kinase F ( 505) 1196 102.8 6.2e-21
XP_011533957 (OMIM: 606573) tyrosine-protein kinas ( 505) 1196 102.8 6.2e-21
XP_005266938 (OMIM: 606573) tyrosine-protein kinas ( 505) 1196 102.8 6.2e-21
XP_011533955 (OMIM: 606573) tyrosine-protein kinas ( 505) 1196 102.8 6.2e-21
>>NP_009298 (OMIM: 164690) tyrosine-protein kinase ABL2 (1182 aa)
initn: 7914 init1: 7914 opt: 7914 Z-score: 3117.3 bits: 588.8 E(92320): 7.3e-167
Smith-Waterman score: 7914; 100.0% identity (100.0% similar) in 1182 aa overlap (1-1182:1-1182)
10 20 30 40 50 60
pF1KE3 MGQQVGRVGEAPGLQQPQPRGIRGSSAARPSGRRRDPAGRTTETGFNIFTQHDHFASCVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 MGQQVGRVGEAPGLQQPQPRGIRGSSAARPSGRRRDPAGRTTETGFNIFTQHDHFASCVE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 DGFEGDKTGGSSPEALHRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 DGFEGDKTGGSSPEALHRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 SGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 SGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 SAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 SAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFST
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 LAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 LAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYG
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE3 EVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 EVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIV
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE3 TEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 TEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGEN
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE3 HVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 HVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIAT
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE3 YGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 YGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFE
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE3 TMFHDSSISEEVAEELGRAASSSSVVPYLPRLPILPSKTRTLKKQVENKENIEGAQDATE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 TMFHDSSISEEVAEELGRAASSSSVVPYLPRLPILPSKTRTLKKQVENKENIEGAQDATE
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE3 NSASSLAPGFIRGAQASSGSPALPRKQRDKSPSSLLEDAKETCFTRDRKGGFFSSFMKKR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 NSASSLAPGFIRGAQASSGSPALPRKQRDKSPSSLLEDAKETCFTRDRKGGFFSSFMKKR
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE3 NAPTPPKRSSSFREMENQPHKKYELTGNFSSVASLQHADGFSFTPAQQEANLVPPKCYGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 NAPTPPKRSSSFREMENQPHKKYELTGNFSSVASLQHADGFSFTPAQQEANLVPPKCYGG
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE3 SFAQRNLCNDDGGGGGGSGTAGGGWSGITGFFTPRLIKKTLGLRAGKPTASDDTSKPFPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 SFAQRNLCNDDGGGGGGSGTAGGGWSGITGFFTPRLIKKTLGLRAGKPTASDDTSKPFPR
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE3 SNSTSSMSSGLPEQDRMAMTLPRNCQRSKLQLERTVSTSSQPEENVDRANDMLPKKSEES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 SNSTSSMSSGLPEQDRMAMTLPRNCQRSKLQLERTVSTSSQPEENVDRANDMLPKKSEES
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE3 AAPSRERPKAKLLPRGATALPLRTPSGDLAITEKDPPGVGVAGVAAAPKGKEKNGGARLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 AAPSRERPKAKLLPRGATALPLRTPSGDLAITEKDPPGVGVAGVAAAPKGKEKNGGARLG
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE3 MAGVPEDGEQPGWPSPAKAAPVLPTTHNHKVPVLISPTLKHTPADVQLIGTDSQGNKFKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 MAGVPEDGEQPGWPSPAKAAPVLPTTHNHKVPVLISPTLKHTPADVQLIGTDSQGNKFKL
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE3 LSEHQVTSSGDKDRPRRVKPKCAPPPPPVMRLLQHPSICSDPTEEPTALTAGQSTSETQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 LSEHQVTSSGDKDRPRRVKPKCAPPPPPVMRLLQHPSICSDPTEEPTALTAGQSTSETQE
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE3 GGKKAALGAVPISGKAGRPVMPPPQVPLPTSSISPAKMANGTAGTKVALRKTKQAAEKIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 GGKKAALGAVPISGKAGRPVMPPPQVPLPTSSISPAKMANGTAGTKVALRKTKQAAEKIS
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE3 ADKISKEALLECADLLSSALTEPVPNSQLVDTGHQLLDYCSGYVDCIPQTRNKFAFREAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 ADKISKEALLECADLLSSALTEPVPNSQLVDTGHQLLDYCSGYVDCIPQTRNKFAFREAV
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180
pF1KE3 SKLELSLQELQVSSAAAGVPGTNPVLNNLLSCVQEISDVVQR
::::::::::::::::::::::::::::::::::::::::::
NP_009 SKLELSLQELQVSSAAAGVPGTNPVLNNLLSCVQEISDVVQR
1150 1160 1170 1180
>>NP_005149 (OMIM: 164690) tyrosine-protein kinase ABL2 (1167 aa)
initn: 7554 init1: 7554 opt: 7554 Z-score: 2976.7 bits: 562.8 E(92320): 4.9e-159
Smith-Waterman score: 7554; 100.0% identity (100.0% similar) in 1130 aa overlap (53-1182:38-1167)
30 40 50 60 70 80
pF1KE3 RGSSAARPSGRRRDPAGRTTETGFNIFTQHDHFASCVEDGFEGDKTGGSSPEALHRPYGC
::::::::::::::::::::::::::::::
NP_005 LPPNSYGRDQDTSLCCLCTEASESALPDLTDHFASCVEDGFEGDKTGGSSPEALHRPYGC
10 20 30 40 50 60
90 100 110 120 130 140
pF1KE3 DVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 DVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQN
70 80 90 100 110 120
150 160 170 180 190 200
pF1KE3 GEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 GEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESES
130 140 150 160 170 180
210 220 230 240 250 260
pF1KE3 SPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 SPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYP
190 200 210 220 230 240
270 280 290 300 310 320
pF1KE3 APKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 APKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKED
250 260 270 280 290 300
330 340 350 360 370 380
pF1KE3 TMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 TMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVT
310 320 330 340 350 360
390 400 410 420 430 440
pF1KE3 AVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 AVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAH
370 380 390 400 410 420
450 460 470 480 490 500
pF1KE3 AGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 AGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGY
430 440 450 460 470 480
510 520 530 540 550 560
pF1KE3 RMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMFHDSSISEEVAEELGRAASS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 RMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMFHDSSISEEVAEELGRAASS
490 500 510 520 530 540
570 580 590 600 610 620
pF1KE3 SSVVPYLPRLPILPSKTRTLKKQVENKENIEGAQDATENSASSLAPGFIRGAQASSGSPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 SSVVPYLPRLPILPSKTRTLKKQVENKENIEGAQDATENSASSLAPGFIRGAQASSGSPA
550 560 570 580 590 600
630 640 650 660 670 680
pF1KE3 LPRKQRDKSPSSLLEDAKETCFTRDRKGGFFSSFMKKRNAPTPPKRSSSFREMENQPHKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 LPRKQRDKSPSSLLEDAKETCFTRDRKGGFFSSFMKKRNAPTPPKRSSSFREMENQPHKK
610 620 630 640 650 660
690 700 710 720 730 740
pF1KE3 YELTGNFSSVASLQHADGFSFTPAQQEANLVPPKCYGGSFAQRNLCNDDGGGGGGSGTAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 YELTGNFSSVASLQHADGFSFTPAQQEANLVPPKCYGGSFAQRNLCNDDGGGGGGSGTAG
670 680 690 700 710 720
750 760 770 780 790 800
pF1KE3 GGWSGITGFFTPRLIKKTLGLRAGKPTASDDTSKPFPRSNSTSSMSSGLPEQDRMAMTLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 GGWSGITGFFTPRLIKKTLGLRAGKPTASDDTSKPFPRSNSTSSMSSGLPEQDRMAMTLP
730 740 750 760 770 780
810 820 830 840 850 860
pF1KE3 RNCQRSKLQLERTVSTSSQPEENVDRANDMLPKKSEESAAPSRERPKAKLLPRGATALPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 RNCQRSKLQLERTVSTSSQPEENVDRANDMLPKKSEESAAPSRERPKAKLLPRGATALPL
790 800 810 820 830 840
870 880 890 900 910 920
pF1KE3 RTPSGDLAITEKDPPGVGVAGVAAAPKGKEKNGGARLGMAGVPEDGEQPGWPSPAKAAPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 RTPSGDLAITEKDPPGVGVAGVAAAPKGKEKNGGARLGMAGVPEDGEQPGWPSPAKAAPV
850 860 870 880 890 900
930 940 950 960 970 980
pF1KE3 LPTTHNHKVPVLISPTLKHTPADVQLIGTDSQGNKFKLLSEHQVTSSGDKDRPRRVKPKC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 LPTTHNHKVPVLISPTLKHTPADVQLIGTDSQGNKFKLLSEHQVTSSGDKDRPRRVKPKC
910 920 930 940 950 960
990 1000 1010 1020 1030 1040
pF1KE3 APPPPPVMRLLQHPSICSDPTEEPTALTAGQSTSETQEGGKKAALGAVPISGKAGRPVMP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 APPPPPVMRLLQHPSICSDPTEEPTALTAGQSTSETQEGGKKAALGAVPISGKAGRPVMP
970 980 990 1000 1010 1020
1050 1060 1070 1080 1090 1100
pF1KE3 PPQVPLPTSSISPAKMANGTAGTKVALRKTKQAAEKISADKISKEALLECADLLSSALTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 PPQVPLPTSSISPAKMANGTAGTKVALRKTKQAAEKISADKISKEALLECADLLSSALTE
1030 1040 1050 1060 1070 1080
1110 1120 1130 1140 1150 1160
pF1KE3 PVPNSQLVDTGHQLLDYCSGYVDCIPQTRNKFAFREAVSKLELSLQELQVSSAAAGVPGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 PVPNSQLVDTGHQLLDYCSGYVDCIPQTRNKFAFREAVSKLELSLQELQVSSAAAGVPGT
1090 1100 1110 1120 1130 1140
1170 1180
pF1KE3 NPVLNNLLSCVQEISDVVQR
::::::::::::::::::::
NP_005 NPVLNNLLSCVQEISDVVQR
1150 1160
>>XP_016856524 (OMIM: 164690) tyrosine-protein kinase AB (1182 aa)
initn: 7407 init1: 7407 opt: 7409 Z-score: 2920.1 bits: 552.3 E(92320): 7.1e-156
Smith-Waterman score: 7409; 99.4% identity (99.6% similar) in 1118 aa overlap (65-1182:65-1182)
40 50 60 70 80 90
pF1KE3 RDPAGRTTETGFNIFTQHDHFASCVEDGFEGDKTGGSSPEALHRPYGCDVEPQALNEAIR
:.. .: :::::::::::::::::::::
XP_016 EMILKYLLIQIDRTASGRGPNKKKKKKEKNGESEELTSEEALHRPYGCDVEPQALNEAIR
40 50 60 70 80 90
100 110 120 130 140 150
pF1KE3 WSSKENLLGATESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 WSSKENLLGATESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQ
100 110 120 130 140 150
160 170 180 190 200 210
pF1KE3 GWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYE
160 170 180 190 200 210
220 230 240 250 260 270
pF1KE3 GRVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GRVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGV
220 230 240 250 260 270
280 290 300 310 320 330
pF1KE3 SPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAA
280 290 300 310 320 330
340 350 360 370 380 390
pF1KE3 VMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQIS
340 350 360 370 380 390
400 410 420 430 440 450
pF1KE3 SAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAP
400 410 420 430 440 450
460 470 480 490 500 510
pF1KE3 ESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKV
460 470 480 490 500 510
520 530 540 550 560 570
pF1KE3 YELMRACWKWSPADRPSFAETHQAFETMFHDSSISEEVAEELGRAASSSSVVPYLPRLPI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YELMRACWKWSPADRPSFAETHQAFETMFHDSSISEEVAEELGRAASSSSVVPYLPRLPI
520 530 540 550 560 570
580 590 600 610 620 630
pF1KE3 LPSKTRTLKKQVENKENIEGAQDATENSASSLAPGFIRGAQASSGSPALPRKQRDKSPSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LPSKTRTLKKQVENKENIEGAQDATENSASSLAPGFIRGAQASSGSPALPRKQRDKSPSS
580 590 600 610 620 630
640 650 660 670 680 690
pF1KE3 LLEDAKETCFTRDRKGGFFSSFMKKRNAPTPPKRSSSFREMENQPHKKYELTGNFSSVAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLEDAKETCFTRDRKGGFFSSFMKKRNAPTPPKRSSSFREMENQPHKKYELTGNFSSVAS
640 650 660 670 680 690
700 710 720 730 740 750
pF1KE3 LQHADGFSFTPAQQEANLVPPKCYGGSFAQRNLCNDDGGGGGGSGTAGGGWSGITGFFTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LQHADGFSFTPAQQEANLVPPKCYGGSFAQRNLCNDDGGGGGGSGTAGGGWSGITGFFTP
700 710 720 730 740 750
760 770 780 790 800 810
pF1KE3 RLIKKTLGLRAGKPTASDDTSKPFPRSNSTSSMSSGLPEQDRMAMTLPRNCQRSKLQLER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RLIKKTLGLRAGKPTASDDTSKPFPRSNSTSSMSSGLPEQDRMAMTLPRNCQRSKLQLER
760 770 780 790 800 810
820 830 840 850 860 870
pF1KE3 TVSTSSQPEENVDRANDMLPKKSEESAAPSRERPKAKLLPRGATALPLRTPSGDLAITEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TVSTSSQPEENVDRANDMLPKKSEESAAPSRERPKAKLLPRGATALPLRTPSGDLAITEK
820 830 840 850 860 870
880 890 900 910 920 930
pF1KE3 DPPGVGVAGVAAAPKGKEKNGGARLGMAGVPEDGEQPGWPSPAKAAPVLPTTHNHKVPVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DPPGVGVAGVAAAPKGKEKNGGARLGMAGVPEDGEQPGWPSPAKAAPVLPTTHNHKVPVL
880 890 900 910 920 930
940 950 960 970 980 990
pF1KE3 ISPTLKHTPADVQLIGTDSQGNKFKLLSEHQVTSSGDKDRPRRVKPKCAPPPPPVMRLLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ISPTLKHTPADVQLIGTDSQGNKFKLLSEHQVTSSGDKDRPRRVKPKCAPPPPPVMRLLQ
940 950 960 970 980 990
1000 1010 1020 1030 1040 1050
pF1KE3 HPSICSDPTEEPTALTAGQSTSETQEGGKKAALGAVPISGKAGRPVMPPPQVPLPTSSIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HPSICSDPTEEPTALTAGQSTSETQEGGKKAALGAVPISGKAGRPVMPPPQVPLPTSSIS
1000 1010 1020 1030 1040 1050
1060 1070 1080 1090 1100 1110
pF1KE3 PAKMANGTAGTKVALRKTKQAAEKISADKISKEALLECADLLSSALTEPVPNSQLVDTGH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PAKMANGTAGTKVALRKTKQAAEKISADKISKEALLECADLLSSALTEPVPNSQLVDTGH
1060 1070 1080 1090 1100 1110
1120 1130 1140 1150 1160 1170
pF1KE3 QLLDYCSGYVDCIPQTRNKFAFREAVSKLELSLQELQVSSAAAGVPGTNPVLNNLLSCVQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QLLDYCSGYVDCIPQTRNKFAFREAVSKLELSLQELQVSSAAAGVPGTNPVLNNLLSCVQ
1120 1130 1140 1150 1160 1170
1180
pF1KE3 EISDVVQR
::::::::
XP_016 EISDVVQR
1180
>>NP_001161708 (OMIM: 164690) tyrosine-protein kinase AB (1161 aa)
initn: 7401 init1: 7401 opt: 7402 Z-score: 2917.4 bits: 551.8 E(92320): 1e-155
Smith-Waterman score: 7709; 98.2% identity (98.2% similar) in 1182 aa overlap (1-1182:1-1161)
10 20 30 40 50 60
pF1KE3 MGQQVGRVGEAPGLQQPQPRGIRGSSAARPSGRRRDPAGRTTETGFNIFTQHDHFASCVE
::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MGQQVGRVGEAPGLQQPQPRGIRGSSAARPSGRRRDPAGRTTETGFNIFTQH--------
10 20 30 40 50
70 80 90 100 110 120
pF1KE3 DGFEGDKTGGSSPEALHRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVA
:::::::::::::::::::::::::::::::::::::::::::::::
NP_001 -------------EALHRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVA
60 70 80 90
130 140 150 160 170 180
pF1KE3 SGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSR
100 110 120 130 140 150
190 200 210 220 230 240
pF1KE3 SAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFST
160 170 180 190 200 210
250 260 270 280 290 300
pF1KE3 LAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYG
220 230 240 250 260 270
310 320 330 340 350 360
pF1KE3 EVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIV
280 290 300 310 320 330
370 380 390 400 410 420
pF1KE3 TEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGEN
340 350 360 370 380 390
430 440 450 460 470 480
pF1KE3 HVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIAT
400 410 420 430 440 450
490 500 510 520 530 540
pF1KE3 YGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFE
460 470 480 490 500 510
550 560 570 580 590 600
pF1KE3 TMFHDSSISEEVAEELGRAASSSSVVPYLPRLPILPSKTRTLKKQVENKENIEGAQDATE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TMFHDSSISEEVAEELGRAASSSSVVPYLPRLPILPSKTRTLKKQVENKENIEGAQDATE
520 530 540 550 560 570
610 620 630 640 650 660
pF1KE3 NSASSLAPGFIRGAQASSGSPALPRKQRDKSPSSLLEDAKETCFTRDRKGGFFSSFMKKR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NSASSLAPGFIRGAQASSGSPALPRKQRDKSPSSLLEDAKETCFTRDRKGGFFSSFMKKR
580 590 600 610 620 630
670 680 690 700 710 720
pF1KE3 NAPTPPKRSSSFREMENQPHKKYELTGNFSSVASLQHADGFSFTPAQQEANLVPPKCYGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NAPTPPKRSSSFREMENQPHKKYELTGNFSSVASLQHADGFSFTPAQQEANLVPPKCYGG
640 650 660 670 680 690
730 740 750 760 770 780
pF1KE3 SFAQRNLCNDDGGGGGGSGTAGGGWSGITGFFTPRLIKKTLGLRAGKPTASDDTSKPFPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SFAQRNLCNDDGGGGGGSGTAGGGWSGITGFFTPRLIKKTLGLRAGKPTASDDTSKPFPR
700 710 720 730 740 750
790 800 810 820 830 840
pF1KE3 SNSTSSMSSGLPEQDRMAMTLPRNCQRSKLQLERTVSTSSQPEENVDRANDMLPKKSEES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SNSTSSMSSGLPEQDRMAMTLPRNCQRSKLQLERTVSTSSQPEENVDRANDMLPKKSEES
760 770 780 790 800 810
850 860 870 880 890 900
pF1KE3 AAPSRERPKAKLLPRGATALPLRTPSGDLAITEKDPPGVGVAGVAAAPKGKEKNGGARLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AAPSRERPKAKLLPRGATALPLRTPSGDLAITEKDPPGVGVAGVAAAPKGKEKNGGARLG
820 830 840 850 860 870
910 920 930 940 950 960
pF1KE3 MAGVPEDGEQPGWPSPAKAAPVLPTTHNHKVPVLISPTLKHTPADVQLIGTDSQGNKFKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAGVPEDGEQPGWPSPAKAAPVLPTTHNHKVPVLISPTLKHTPADVQLIGTDSQGNKFKL
880 890 900 910 920 930
970 980 990 1000 1010 1020
pF1KE3 LSEHQVTSSGDKDRPRRVKPKCAPPPPPVMRLLQHPSICSDPTEEPTALTAGQSTSETQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LSEHQVTSSGDKDRPRRVKPKCAPPPPPVMRLLQHPSICSDPTEEPTALTAGQSTSETQE
940 950 960 970 980 990
1030 1040 1050 1060 1070 1080
pF1KE3 GGKKAALGAVPISGKAGRPVMPPPQVPLPTSSISPAKMANGTAGTKVALRKTKQAAEKIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GGKKAALGAVPISGKAGRPVMPPPQVPLPTSSISPAKMANGTAGTKVALRKTKQAAEKIS
1000 1010 1020 1030 1040 1050
1090 1100 1110 1120 1130 1140
pF1KE3 ADKISKEALLECADLLSSALTEPVPNSQLVDTGHQLLDYCSGYVDCIPQTRNKFAFREAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ADKISKEALLECADLLSSALTEPVPNSQLVDTGHQLLDYCSGYVDCIPQTRNKFAFREAV
1060 1070 1080 1090 1100 1110
1150 1160 1170 1180
pF1KE3 SKLELSLQELQVSSAAAGVPGTNPVLNNLLSCVQEISDVVQR
::::::::::::::::::::::::::::::::::::::::::
NP_001 SKLELSLQELQVSSAAAGVPGTNPVLNNLLSCVQEISDVVQR
1120 1130 1140 1150 1160
>>XP_005245145 (OMIM: 164690) tyrosine-protein kinase AB (1146 aa)
initn: 7401 init1: 7401 opt: 7401 Z-score: 2917.1 bits: 551.7 E(92320): 1e-155
Smith-Waterman score: 7401; 100.0% identity (100.0% similar) in 1109 aa overlap (74-1182:38-1146)
50 60 70 80 90 100
pF1KE3 TGFNIFTQHDHFASCVEDGFEGDKTGGSSPEALHRPYGCDVEPQALNEAIRWSSKENLLG
::::::::::::::::::::::::::::::
XP_005 LPPNSYGRDQDTSLCCLCTEASESALPDLTEALHRPYGCDVEPQALNEAIRWSSKENLLG
10 20 30 40 50 60
110 120 130 140 150 160
pF1KE3 ATESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYIT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ATESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYIT
70 80 90 100 110 120
170 180 190 200 210 220
pF1KE3 PVNSLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRIN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PVNSLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRIN
130 140 150 160 170 180
230 240 250 260 270 280
pF1KE3 TTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEM
190 200 210 220 230 240
290 300 310 320 330 340
pF1KE3 ERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPN
250 260 270 280 290 300
350 360 370 380 390 400
pF1KE3 LVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKK
310 320 330 340 350 360
410 420 430 440 450 460
pF1KE3 NFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFS
370 380 390 400 410 420
470 480 490 500 510 520
pF1KE3 IKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWK
430 440 450 460 470 480
530 540 550 560 570 580
pF1KE3 WSPADRPSFAETHQAFETMFHDSSISEEVAEELGRAASSSSVVPYLPRLPILPSKTRTLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 WSPADRPSFAETHQAFETMFHDSSISEEVAEELGRAASSSSVVPYLPRLPILPSKTRTLK
490 500 510 520 530 540
590 600 610 620 630 640
pF1KE3 KQVENKENIEGAQDATENSASSLAPGFIRGAQASSGSPALPRKQRDKSPSSLLEDAKETC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KQVENKENIEGAQDATENSASSLAPGFIRGAQASSGSPALPRKQRDKSPSSLLEDAKETC
550 560 570 580 590 600
650 660 670 680 690 700
pF1KE3 FTRDRKGGFFSSFMKKRNAPTPPKRSSSFREMENQPHKKYELTGNFSSVASLQHADGFSF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FTRDRKGGFFSSFMKKRNAPTPPKRSSSFREMENQPHKKYELTGNFSSVASLQHADGFSF
610 620 630 640 650 660
710 720 730 740 750 760
pF1KE3 TPAQQEANLVPPKCYGGSFAQRNLCNDDGGGGGGSGTAGGGWSGITGFFTPRLIKKTLGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TPAQQEANLVPPKCYGGSFAQRNLCNDDGGGGGGSGTAGGGWSGITGFFTPRLIKKTLGL
670 680 690 700 710 720
770 780 790 800 810 820
pF1KE3 RAGKPTASDDTSKPFPRSNSTSSMSSGLPEQDRMAMTLPRNCQRSKLQLERTVSTSSQPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RAGKPTASDDTSKPFPRSNSTSSMSSGLPEQDRMAMTLPRNCQRSKLQLERTVSTSSQPE
730 740 750 760 770 780
830 840 850 860 870 880
pF1KE3 ENVDRANDMLPKKSEESAAPSRERPKAKLLPRGATALPLRTPSGDLAITEKDPPGVGVAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ENVDRANDMLPKKSEESAAPSRERPKAKLLPRGATALPLRTPSGDLAITEKDPPGVGVAG
790 800 810 820 830 840
890 900 910 920 930 940
pF1KE3 VAAAPKGKEKNGGARLGMAGVPEDGEQPGWPSPAKAAPVLPTTHNHKVPVLISPTLKHTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VAAAPKGKEKNGGARLGMAGVPEDGEQPGWPSPAKAAPVLPTTHNHKVPVLISPTLKHTP
850 860 870 880 890 900
950 960 970 980 990 1000
pF1KE3 ADVQLIGTDSQGNKFKLLSEHQVTSSGDKDRPRRVKPKCAPPPPPVMRLLQHPSICSDPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ADVQLIGTDSQGNKFKLLSEHQVTSSGDKDRPRRVKPKCAPPPPPVMRLLQHPSICSDPT
910 920 930 940 950 960
1010 1020 1030 1040 1050 1060
pF1KE3 EEPTALTAGQSTSETQEGGKKAALGAVPISGKAGRPVMPPPQVPLPTSSISPAKMANGTA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EEPTALTAGQSTSETQEGGKKAALGAVPISGKAGRPVMPPPQVPLPTSSISPAKMANGTA
970 980 990 1000 1010 1020
1070 1080 1090 1100 1110 1120
pF1KE3 GTKVALRKTKQAAEKISADKISKEALLECADLLSSALTEPVPNSQLVDTGHQLLDYCSGY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GTKVALRKTKQAAEKISADKISKEALLECADLLSSALTEPVPNSQLVDTGHQLLDYCSGY
1030 1040 1050 1060 1070 1080
1130 1140 1150 1160 1170 1180
pF1KE3 VDCIPQTRNKFAFREAVSKLELSLQELQVSSAAAGVPGTNPVLNNLLSCVQEISDVVQR
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VDCIPQTRNKFAFREAVSKLELSLQELQVSSAAAGVPGTNPVLNNLLSCVQEISDVVQR
1090 1100 1110 1120 1130 1140
>>NP_001161709 (OMIM: 164690) tyrosine-protein kinase AB (1079 aa)
initn: 4653 init1: 4614 opt: 4614 Z-score: 1828.9 bits: 350.3 E(92320): 4.2e-95
Smith-Waterman score: 6990; 91.3% identity (91.3% similar) in 1182 aa overlap (1-1182:1-1079)
10 20 30 40 50 60
pF1KE3 MGQQVGRVGEAPGLQQPQPRGIRGSSAARPSGRRRDPAGRTTETGFNIFTQHDHFASCVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MGQQVGRVGEAPGLQQPQPRGIRGSSAARPSGRRRDPAGRTTETGFNIFTQHDHFASCVE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 DGFEGDKTGGSSPEALHRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DGFEGDKTGGSSPEALHRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 SGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 SAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFST
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 LAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYG
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE3 EVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIV
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE3 TEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGEN
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE3 HVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIAT
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE3 YGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFE
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE3 TMFHDSSISEEVAEELGRAASSSSVVPYLPRLPILPSKTRTLKKQVENKENIEGAQDATE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TMFHDSSISEEVAEELGRAASSSSVVPYLPRLPILPSKTRTLKKQVENKENIEGAQDATE
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE3 NSASSLAPGFIRGAQASSGSPALPRKQRDKSPSSLLEDAKETCFTRDRKGGFFSSFMKKR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NSASSLAPGFIRGAQASSGSPALPRKQRDKSPSSLLEDAKETCFTRDRKGGFFSSFMKKR
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE3 NAPTPPKRSSSFREMENQPHKKYELTGNFSSVASLQHADGFSFTPAQQEANLVPPKCYGG
:::::::::::::::::::::::::::
NP_001 NAPTPPKRSSSFREMENQPHKKYELTG---------------------------------
670 680
730 740 750 760 770 780
pF1KE3 SFAQRNLCNDDGGGGGGSGTAGGGWSGITGFFTPRLIKKTLGLRAGKPTASDDTSKPFPR
NP_001 ------------------------------------------------------------
790 800 810 820 830 840
pF1KE3 SNSTSSMSSGLPEQDRMAMTLPRNCQRSKLQLERTVSTSSQPEENVDRANDMLPKKSEES
::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ----------LPEQDRMAMTLPRNCQRSKLQLERTVSTSSQPEENVDRANDMLPKKSEES
690 700 710 720 730
850 860 870 880 890 900
pF1KE3 AAPSRERPKAKLLPRGATALPLRTPSGDLAITEKDPPGVGVAGVAAAPKGKEKNGGARLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AAPSRERPKAKLLPRGATALPLRTPSGDLAITEKDPPGVGVAGVAAAPKGKEKNGGARLG
740 750 760 770 780 790
910 920 930 940 950 960
pF1KE3 MAGVPEDGEQPGWPSPAKAAPVLPTTHNHKVPVLISPTLKHTPADVQLIGTDSQGNKFKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAGVPEDGEQPGWPSPAKAAPVLPTTHNHKVPVLISPTLKHTPADVQLIGTDSQGNKFKL
800 810 820 830 840 850
970 980 990 1000 1010 1020
pF1KE3 LSEHQVTSSGDKDRPRRVKPKCAPPPPPVMRLLQHPSICSDPTEEPTALTAGQSTSETQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LSEHQVTSSGDKDRPRRVKPKCAPPPPPVMRLLQHPSICSDPTEEPTALTAGQSTSETQE
860 870 880 890 900 910
1030 1040 1050 1060 1070 1080
pF1KE3 GGKKAALGAVPISGKAGRPVMPPPQVPLPTSSISPAKMANGTAGTKVALRKTKQAAEKIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GGKKAALGAVPISGKAGRPVMPPPQVPLPTSSISPAKMANGTAGTKVALRKTKQAAEKIS
920 930 940 950 960 970
1090 1100 1110 1120 1130 1140
pF1KE3 ADKISKEALLECADLLSSALTEPVPNSQLVDTGHQLLDYCSGYVDCIPQTRNKFAFREAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ADKISKEALLECADLLSSALTEPVPNSQLVDTGHQLLDYCSGYVDCIPQTRNKFAFREAV
980 990 1000 1010 1020 1030
1150 1160 1170 1180
pF1KE3 SKLELSLQELQVSSAAAGVPGTNPVLNNLLSCVQEISDVVQR
::::::::::::::::::::::::::::::::::::::::::
NP_001 SKLELSLQELQVSSAAAGVPGTNPVLNNLLSCVQEISDVVQR
1040 1050 1060 1070
>>NP_001129472 (OMIM: 164690) tyrosine-protein kinase AB (1064 aa)
initn: 4293 init1: 4254 opt: 4254 Z-score: 1688.4 bits: 324.2 E(92320): 2.9e-87
Smith-Waterman score: 6630; 90.9% identity (90.9% similar) in 1130 aa overlap (53-1182:38-1064)
30 40 50 60 70 80
pF1KE3 RGSSAARPSGRRRDPAGRTTETGFNIFTQHDHFASCVEDGFEGDKTGGSSPEALHRPYGC
::::::::::::::::::::::::::::::
NP_001 LPPNSYGRDQDTSLCCLCTEASESALPDLTDHFASCVEDGFEGDKTGGSSPEALHRPYGC
10 20 30 40 50 60
90 100 110 120 130 140
pF1KE3 DVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQN
70 80 90 100 110 120
150 160 170 180 190 200
pF1KE3 GEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESES
130 140 150 160 170 180
210 220 230 240 250 260
pF1KE3 SPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYP
190 200 210 220 230 240
270 280 290 300 310 320
pF1KE3 APKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 APKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKED
250 260 270 280 290 300
330 340 350 360 370 380
pF1KE3 TMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVT
310 320 330 340 350 360
390 400 410 420 430 440
pF1KE3 AVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAH
370 380 390 400 410 420
450 460 470 480 490 500
pF1KE3 AGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGY
430 440 450 460 470 480
510 520 530 540 550 560
pF1KE3 RMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMFHDSSISEEVAEELGRAASS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMFHDSSISEEVAEELGRAASS
490 500 510 520 530 540
570 580 590 600 610 620
pF1KE3 SSVVPYLPRLPILPSKTRTLKKQVENKENIEGAQDATENSASSLAPGFIRGAQASSGSPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSVVPYLPRLPILPSKTRTLKKQVENKENIEGAQDATENSASSLAPGFIRGAQASSGSPA
550 560 570 580 590 600
630 640 650 660 670 680
pF1KE3 LPRKQRDKSPSSLLEDAKETCFTRDRKGGFFSSFMKKRNAPTPPKRSSSFREMENQPHKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LPRKQRDKSPSSLLEDAKETCFTRDRKGGFFSSFMKKRNAPTPPKRSSSFREMENQPHKK
610 620 630 640 650 660
690 700 710 720 730 740
pF1KE3 YELTGNFSSVASLQHADGFSFTPAQQEANLVPPKCYGGSFAQRNLCNDDGGGGGGSGTAG
:::::
NP_001 YELTG-------------------------------------------------------
670
750 760 770 780 790 800
pF1KE3 GGWSGITGFFTPRLIKKTLGLRAGKPTASDDTSKPFPRSNSTSSMSSGLPEQDRMAMTLP
::::::::::::
NP_001 ------------------------------------------------LPEQDRMAMTLP
680
810 820 830 840 850 860
pF1KE3 RNCQRSKLQLERTVSTSSQPEENVDRANDMLPKKSEESAAPSRERPKAKLLPRGATALPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RNCQRSKLQLERTVSTSSQPEENVDRANDMLPKKSEESAAPSRERPKAKLLPRGATALPL
690 700 710 720 730 740
870 880 890 900 910 920
pF1KE3 RTPSGDLAITEKDPPGVGVAGVAAAPKGKEKNGGARLGMAGVPEDGEQPGWPSPAKAAPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RTPSGDLAITEKDPPGVGVAGVAAAPKGKEKNGGARLGMAGVPEDGEQPGWPSPAKAAPV
750 760 770 780 790 800
930 940 950 960 970 980
pF1KE3 LPTTHNHKVPVLISPTLKHTPADVQLIGTDSQGNKFKLLSEHQVTSSGDKDRPRRVKPKC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LPTTHNHKVPVLISPTLKHTPADVQLIGTDSQGNKFKLLSEHQVTSSGDKDRPRRVKPKC
810 820 830 840 850 860
990 1000 1010 1020 1030 1040
pF1KE3 APPPPPVMRLLQHPSICSDPTEEPTALTAGQSTSETQEGGKKAALGAVPISGKAGRPVMP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 APPPPPVMRLLQHPSICSDPTEEPTALTAGQSTSETQEGGKKAALGAVPISGKAGRPVMP
870 880 890 900 910 920
1050 1060 1070 1080 1090 1100
pF1KE3 PPQVPLPTSSISPAKMANGTAGTKVALRKTKQAAEKISADKISKEALLECADLLSSALTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PPQVPLPTSSISPAKMANGTAGTKVALRKTKQAAEKISADKISKEALLECADLLSSALTE
930 940 950 960 970 980
1110 1120 1130 1140 1150 1160
pF1KE3 PVPNSQLVDTGHQLLDYCSGYVDCIPQTRNKFAFREAVSKLELSLQELQVSSAAAGVPGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PVPNSQLVDTGHQLLDYCSGYVDCIPQTRNKFAFREAVSKLELSLQELQVSSAAAGVPGT
990 1000 1010 1020 1030 1040
1170 1180
pF1KE3 NPVLNNLLSCVQEISDVVQR
::::::::::::::::::::
NP_001 NPVLNNLLSCVQEISDVVQR
1050 1060
>>NP_001161710 (OMIM: 164690) tyrosine-protein kinase AB (1058 aa)
initn: 4140 init1: 4101 opt: 4102 Z-score: 1629.0 bits: 313.3 E(92320): 5.8e-84
Smith-Waterman score: 6785; 89.5% identity (89.5% similar) in 1182 aa overlap (1-1182:1-1058)
10 20 30 40 50 60
pF1KE3 MGQQVGRVGEAPGLQQPQPRGIRGSSAARPSGRRRDPAGRTTETGFNIFTQHDHFASCVE
::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MGQQVGRVGEAPGLQQPQPRGIRGSSAARPSGRRRDPAGRTTETGFNIFTQH--------
10 20 30 40 50
70 80 90 100 110 120
pF1KE3 DGFEGDKTGGSSPEALHRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVA
:::::::::::::::::::::::::::::::::::::::::::::::
NP_001 -------------EALHRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVA
60 70 80 90
130 140 150 160 170 180
pF1KE3 SGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSR
100 110 120 130 140 150
190 200 210 220 230 240
pF1KE3 SAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFST
160 170 180 190 200 210
250 260 270 280 290 300
pF1KE3 LAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYG
220 230 240 250 260 270
310 320 330 340 350 360
pF1KE3 EVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIV
280 290 300 310 320 330
370 380 390 400 410 420
pF1KE3 TEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGEN
340 350 360 370 380 390
430 440 450 460 470 480
pF1KE3 HVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIAT
400 410 420 430 440 450
490 500 510 520 530 540
pF1KE3 YGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFE
460 470 480 490 500 510
550 560 570 580 590 600
pF1KE3 TMFHDSSISEEVAEELGRAASSSSVVPYLPRLPILPSKTRTLKKQVENKENIEGAQDATE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TMFHDSSISEEVAEELGRAASSSSVVPYLPRLPILPSKTRTLKKQVENKENIEGAQDATE
520 530 540 550 560 570
610 620 630 640 650 660
pF1KE3 NSASSLAPGFIRGAQASSGSPALPRKQRDKSPSSLLEDAKETCFTRDRKGGFFSSFMKKR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NSASSLAPGFIRGAQASSGSPALPRKQRDKSPSSLLEDAKETCFTRDRKGGFFSSFMKKR
580 590 600 610 620 630
670 680 690 700 710 720
pF1KE3 NAPTPPKRSSSFREMENQPHKKYELTGNFSSVASLQHADGFSFTPAQQEANLVPPKCYGG
:::::::::::::::::::::::::::
NP_001 NAPTPPKRSSSFREMENQPHKKYELTG---------------------------------
640 650 660
730 740 750 760 770 780
pF1KE3 SFAQRNLCNDDGGGGGGSGTAGGGWSGITGFFTPRLIKKTLGLRAGKPTASDDTSKPFPR
NP_001 ------------------------------------------------------------
790 800 810 820 830 840
pF1KE3 SNSTSSMSSGLPEQDRMAMTLPRNCQRSKLQLERTVSTSSQPEENVDRANDMLPKKSEES
::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ----------LPEQDRMAMTLPRNCQRSKLQLERTVSTSSQPEENVDRANDMLPKKSEES
670 680 690 700 710
850 860 870 880 890 900
pF1KE3 AAPSRERPKAKLLPRGATALPLRTPSGDLAITEKDPPGVGVAGVAAAPKGKEKNGGARLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AAPSRERPKAKLLPRGATALPLRTPSGDLAITEKDPPGVGVAGVAAAPKGKEKNGGARLG
720 730 740 750 760 770
910 920 930 940 950 960
pF1KE3 MAGVPEDGEQPGWPSPAKAAPVLPTTHNHKVPVLISPTLKHTPADVQLIGTDSQGNKFKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAGVPEDGEQPGWPSPAKAAPVLPTTHNHKVPVLISPTLKHTPADVQLIGTDSQGNKFKL
780 790 800 810 820 830
970 980 990 1000 1010 1020
pF1KE3 LSEHQVTSSGDKDRPRRVKPKCAPPPPPVMRLLQHPSICSDPTEEPTALTAGQSTSETQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LSEHQVTSSGDKDRPRRVKPKCAPPPPPVMRLLQHPSICSDPTEEPTALTAGQSTSETQE
840 850 860 870 880 890
1030 1040 1050 1060 1070 1080
pF1KE3 GGKKAALGAVPISGKAGRPVMPPPQVPLPTSSISPAKMANGTAGTKVALRKTKQAAEKIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GGKKAALGAVPISGKAGRPVMPPPQVPLPTSSISPAKMANGTAGTKVALRKTKQAAEKIS
900 910 920 930 940 950
1090 1100 1110 1120 1130 1140
pF1KE3 ADKISKEALLECADLLSSALTEPVPNSQLVDTGHQLLDYCSGYVDCIPQTRNKFAFREAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ADKISKEALLECADLLSSALTEPVPNSQLVDTGHQLLDYCSGYVDCIPQTRNKFAFREAV
960 970 980 990 1000 1010
1150 1160 1170 1180
pF1KE3 SKLELSLQELQVSSAAAGVPGTNPVLNNLLSCVQEISDVVQR
::::::::::::::::::::::::::::::::::::::::::
NP_001 SKLELSLQELQVSSAAAGVPGTNPVLNNLLSCVQEISDVVQR
1020 1030 1040 1050
>>NP_001161711 (OMIM: 164690) tyrosine-protein kinase AB (1043 aa)
initn: 4140 init1: 4101 opt: 4101 Z-score: 1628.7 bits: 313.2 E(92320): 6e-84
Smith-Waterman score: 6477; 90.7% identity (90.7% similar) in 1109 aa overlap (74-1182:38-1043)
50 60 70 80 90 100
pF1KE3 TGFNIFTQHDHFASCVEDGFEGDKTGGSSPEALHRPYGCDVEPQALNEAIRWSSKENLLG
::::::::::::::::::::::::::::::
NP_001 LPPNSYGRDQDTSLCCLCTEASESALPDLTEALHRPYGCDVEPQALNEAIRWSSKENLLG
10 20 30 40 50 60
110 120 130 140 150 160
pF1KE3 ATESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYIT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ATESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYIT
70 80 90 100 110 120
170 180 190 200 210 220
pF1KE3 PVNSLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRIN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PVNSLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRIN
130 140 150 160 170 180
230 240 250 260 270 280
pF1KE3 TTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEM
190 200 210 220 230 240
290 300 310 320 330 340
pF1KE3 ERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPN
250 260 270 280 290 300
350 360 370 380 390 400
pF1KE3 LVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKK
310 320 330 340 350 360
410 420 430 440 450 460
pF1KE3 NFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFS
370 380 390 400 410 420
470 480 490 500 510 520
pF1KE3 IKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWK
430 440 450 460 470 480
530 540 550 560 570 580
pF1KE3 WSPADRPSFAETHQAFETMFHDSSISEEVAEELGRAASSSSVVPYLPRLPILPSKTRTLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 WSPADRPSFAETHQAFETMFHDSSISEEVAEELGRAASSSSVVPYLPRLPILPSKTRTLK
490 500 510 520 530 540
590 600 610 620 630 640
pF1KE3 KQVENKENIEGAQDATENSASSLAPGFIRGAQASSGSPALPRKQRDKSPSSLLEDAKETC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KQVENKENIEGAQDATENSASSLAPGFIRGAQASSGSPALPRKQRDKSPSSLLEDAKETC
550 560 570 580 590 600
650 660 670 680 690 700
pF1KE3 FTRDRKGGFFSSFMKKRNAPTPPKRSSSFREMENQPHKKYELTGNFSSVASLQHADGFSF
::::::::::::::::::::::::::::::::::::::::::::
NP_001 FTRDRKGGFFSSFMKKRNAPTPPKRSSSFREMENQPHKKYELTG----------------
610 620 630 640 650
710 720 730 740 750 760
pF1KE3 TPAQQEANLVPPKCYGGSFAQRNLCNDDGGGGGGSGTAGGGWSGITGFFTPRLIKKTLGL
NP_001 ------------------------------------------------------------
770 780 790 800 810 820
pF1KE3 RAGKPTASDDTSKPFPRSNSTSSMSSGLPEQDRMAMTLPRNCQRSKLQLERTVSTSSQPE
:::::::::::::::::::::::::::::::::
NP_001 ---------------------------LPEQDRMAMTLPRNCQRSKLQLERTVSTSSQPE
660 670 680
830 840 850 860 870 880
pF1KE3 ENVDRANDMLPKKSEESAAPSRERPKAKLLPRGATALPLRTPSGDLAITEKDPPGVGVAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ENVDRANDMLPKKSEESAAPSRERPKAKLLPRGATALPLRTPSGDLAITEKDPPGVGVAG
690 700 710 720 730 740
890 900 910 920 930 940
pF1KE3 VAAAPKGKEKNGGARLGMAGVPEDGEQPGWPSPAKAAPVLPTTHNHKVPVLISPTLKHTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VAAAPKGKEKNGGARLGMAGVPEDGEQPGWPSPAKAAPVLPTTHNHKVPVLISPTLKHTP
750 760 770 780 790 800
950 960 970 980 990 1000
pF1KE3 ADVQLIGTDSQGNKFKLLSEHQVTSSGDKDRPRRVKPKCAPPPPPVMRLLQHPSICSDPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ADVQLIGTDSQGNKFKLLSEHQVTSSGDKDRPRRVKPKCAPPPPPVMRLLQHPSICSDPT
810 820 830 840 850 860
1010 1020 1030 1040 1050 1060
pF1KE3 EEPTALTAGQSTSETQEGGKKAALGAVPISGKAGRPVMPPPQVPLPTSSISPAKMANGTA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EEPTALTAGQSTSETQEGGKKAALGAVPISGKAGRPVMPPPQVPLPTSSISPAKMANGTA
870 880 890 900 910 920
1070 1080 1090 1100 1110 1120
pF1KE3 GTKVALRKTKQAAEKISADKISKEALLECADLLSSALTEPVPNSQLVDTGHQLLDYCSGY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GTKVALRKTKQAAEKISADKISKEALLECADLLSSALTEPVPNSQLVDTGHQLLDYCSGY
930 940 950 960 970 980
1130 1140 1150 1160 1170 1180
pF1KE3 VDCIPQTRNKFAFREAVSKLELSLQELQVSSAAAGVPGTNPVLNNLLSCVQEISDVVQR
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VDCIPQTRNKFAFREAVSKLELSLQELQVSSAAAGVPGTNPVLNNLLSCVQEISDVVQR
990 1000 1010 1020 1030 1040
>>NP_005148 (OMIM: 189980,608232,617602) tyrosine-protei (1130 aa)
initn: 3269 init1: 2813 opt: 3371 Z-score: 1343.3 bits: 260.5 E(92320): 4.8e-68
Smith-Waterman score: 3643; 54.5% identity (72.5% similar) in 1162 aa overlap (74-1182:27-1130)
50 60 70 80 90 100
pF1KE3 TGFNIFTQHDHFASCVEDGFEGDKTGGSSPEALHRPYGCDVEPQALNEAIRWSSKENLL-
:::.:: . : :::.:.:: ::.::::::
NP_005 MLEICLKLVGCKSKKGLSSSSSCYLEEALQRPVASDFEPQGLSEAARWNSKENLLA
10 20 30 40 50
110 120 130 140 150 160
pF1KE3 GATESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYI
: .:.:::::::::::::::::::::::::::::::::.:::: :...::::::::::::
NP_005 GPSENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYI
60 70 80 90 100 110
170 180 190 200 210 220
pF1KE3 TPVNSLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRI
::::::::::::::::::.:::::::: :::::::::::::::: :::::::::::::::
NP_005 TPVNSLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRI
120 130 140 150 160 170
230 240 250 260 270 280
pF1KE3 NTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWE
::..:::.::..::::.::::::::::::::::.::::::::: :::::::::: .::::
NP_005 NTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKWE
180 190 200 210 220 230
290 300 310 320 330 340
pF1KE3 MERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHP
::::::::::::::::::::: ::::::::::::::::::::::::::::::::::::::
NP_005 MERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHP
240 250 260 270 280 290
350 360 370 380 390 400
pF1KE3 NLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEK
:::::::::: ::::::.::.: :::::::::::::.::.::::::::::::::::::::
NP_005 NLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEK
300 310 320 330 340 350
410 420 430 440 450 460
pF1KE3 KNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTF
:::::::::::::::::::.:::::::::::::::::::::::::::::::::::::: :
NP_005 KNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKF
360 370 380 390 400 410
470 480 490 500 510 520
pF1KE3 SIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACW
:::::::::::::::::::::::::::::::::.:::: ::::.::::: ::::::::::
NP_005 SIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACW
420 430 440 450 460 470
530 540 550 560 570 580
pF1KE3 KWSPADRPSFAETHQAFETMFHDSSISEEVAEELGRAASSSSVVPYLPRLPILPSKTRTL
.:.:.::::::: ::::::::..::::.:: .:::. . ..: : . : ::.::::
NP_005 QWNPSDRPSFAEIHQAFETMFQESSISDEVEKELGKQGVRGAVSTLL-QAPELPTKTRTS
480 490 500 510 520 530
590 600 610 620 630 640
pF1KE3 KKQVENKENIEGAQDATENSASSLAPGFIRGAQASSGSPALPRKQRDKSPSSLLEDAKET
.. .:.... . . .. . : . . :: ::::.: ..: :: :
NP_005 RRAAEHRDTTDVPEMPHSKGQGESDPL----DHEPAVSPLLPRKERGPPEGGLNED--ER
540 550 560 570 580
650 660 670 680 690 700
pF1KE3 CFTRDRKGGFFSSFMKKRN--APTPPKRSSSFREMENQPHKKYELTGNFSSVASLQHADG
. .:.: ..::...::.. ::::::::::::::..::... . .... .
NP_005 LLPKDKKTNLFSALIKKKKKTAPTPPKRSSSFREMDGQPERRGAGEEEGRDISN----GA
590 600 610 620 630 640
710 720 730 740 750 760
pF1KE3 FSFTPAQQEANLVPPKCYGGSFAQRNLCNDDGGGGGGSGTAGGGWSGITGFFTPRLIKKT
..::: . :: .:. : .:. .:: .:: .:.: ::.
NP_005 LAFTPLDTADPAKSPKPSNGA-----------GVPNGALRESGG----SGFRSPHLWKKS
650 660 670 680 690
770 780 790 800 810
pF1KE3 LGLRA-----GKPTASDDTSKPFPRSNSTSSMSSGLPEQDRMAMTLPRNCQRSKLQLERT
: . :. .. ..:: : :: :.: . : . . ..::::. : . :.. .
NP_005 STLTSSRLATGEEEGGGSSSKRFLRSCSASCVPHGAKDTEWRSVTLPRDLQSTGRQFDSS
700 710 720 730 740 750
820 830 840 850 860 870
pF1KE3 VSTSSQPEENVDRANDMLPKKSEESAAPSRERPKAKLLPRGATALPLR-TPSGDLAITE-
. . . :. . ::.: :. .: . . ::... : : . ... : :
NP_005 TFGGHKSEKPA------LPRKR---AGENR----SDQVTRGTVTPPPRLVKKNEEAADEV
760 770 780 790
880 890 900 910 920
pF1KE3 -KD----PPGVGVAGVAAAPKGKEKNGGARLGMAGVPEDGEQPGWPSPAKAAPVLPTTHN
:: :: . ... : .. . . :. : :. . .:: : :: ::.
NP_005 FKDIMESSPGSSPPNLTPKPLRRQVTVAPASGLPHKEEAGKGSALGTPAAAEPVTPTS--
800 810 820 830 840 850
930 940 950 960 970 980
pF1KE3 HKVPVLISPTLKHTPADVQLIGTDSQGNKFKLLSEHQVTSSG-DKDRPRRVKPKCAPPPP
:. .. ::. .:. . : :. : : :: . :.:: :::::
NP_005 -KAGSGAPGGTSKGPAE------ESRVRRHK----HSSESPGRDKGKLSRLKP--APPPP
860 870 880 890 900
990 1000 1010 1020
pF1KE3 PVMRLLQHPSICSDPTEEPTALTAGQST---------------------SETQEGGKKAA
:. . . . :.. :. .::... :. :: :: .
NP_005 PAA---SAGKAGGKPSQSPSQEAAGEAVLGAKTKATSLVDAVNSDAAKPSQPGEGLKKPV
910 920 930 940 950
1030 1040 1050 1060 1070
pF1KE3 LGAVPISGKA---GRPVMPPPQVP--LPTSSISPA-KMANGTA-----GTKVALRKTKQA
: :.: .: : :. : : :: ::..: . : . ..:: .:.:.::::.:
NP_005 LPATPKPQSAKPSGTPISPAP-VPSTLPSASSALAGDQPSSTAFIPLISTRVSLRKTRQP
960 970 980 990 1000 1010
1080 1090 1100 1110 1120 1130
pF1KE3 AEKISADKISKEALLECADLLSSALT----EPVPNSQLVDTGHQLLDYCSGYVDCIPQTR
:.:.. :.: ..:. .. : :.. . . .: ....:..: .: .::: : : :
NP_005 PERIASGAITKGVVLDSTEALCLAISRNSEQMASHSAVLEAGKNLYTFCVSYVDSIQQMR
1020 1030 1040 1050 1060 1070
1140 1150 1160 1170 1180
pF1KE3 NKFAFREAVSKLELSLQELQVSSAAAGV-PGTNPVLNNLLSCVQEISDVVQR
::::::::..::: .:.:::. :.:: :... ...::: :.::::.:::
NP_005 NKFAFREAINKLENNLRELQICPATAGSGPAATQDFSKLLSSVKEISDIVQR
1080 1090 1100 1110 1120 1130
1182 residues in 1 query sequences
64369986 residues in 92320 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Oct 24 21:49:50 2019 done: Thu Oct 24 21:49:52 2019
Total Scan time: 8.670 Total Display time: 0.320
Function used was FASTA [36.3.4 Apr, 2011]