Result of FASTA (omim) for
pFN21AE2436
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE2436, 748 aa
1>>>pF1KE2436 748 - 748 aa - 748 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 9.3390+/-0.000331; mu= 1.5796+/- 0.021
mean_var=189.6234+/-38.877, 0's: 0 Z-trim(121.2): 27 B-trim: 0 in 0/59
Lambda= 0.093138
statistics sampled from 37338 (37365) to 37338 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.747), E-opt: 0.2 (0.438), width: 16
Scan time: 13.080
The best scores are: opt bits E(85289)
NP_001073866 (OMIM: 605763) proton-associated suga ( 782) 5053 691.6 3.2e-198
XP_011539832 (OMIM: 605763) PREDICTED: proton-asso ( 790) 5027 688.1 3.7e-197
XP_011539833 (OMIM: 605763) PREDICTED: proton-asso ( 759) 3875 533.3 1.4e-150
NP_057264 (OMIM: 227240,606202,606574) membrane-as ( 530) 615 95.2 7.6e-19
NP_001284346 (OMIM: 227240,606202,606574) membrane ( 243) 570 89.0 2.5e-17
NP_001012527 (OMIM: 227240,606202,606574) membrane ( 460) 477 76.6 2.6e-13
XP_005245617 (OMIM: 605097) PREDICTED: solute carr ( 328) 393 65.3 4.8e-10
XP_016858127 (OMIM: 605097) PREDICTED: solute carr ( 553) 333 57.3 2e-07
NP_149093 (OMIM: 605097) solute carrier family 45 ( 553) 333 57.3 2e-07
XP_005245613 (OMIM: 605097) PREDICTED: solute carr ( 553) 333 57.3 2e-07
XP_005245614 (OMIM: 605097) PREDICTED: solute carr ( 553) 333 57.3 2e-07
>>NP_001073866 (OMIM: 605763) proton-associated sugar tr (782 aa)
initn: 5053 init1: 5053 opt: 5053 Z-score: 3679.6 bits: 691.6 E(85289): 3.2e-198
Smith-Waterman score: 5053; 100.0% identity (100.0% similar) in 748 aa overlap (1-748:35-782)
10 20 30
pF1KE2 MIPAASSTPPGDALFPSVAPQDFWRSQVTG
::::::::::::::::::::::::::::::
NP_001 PGPRPGRQQPSGDRDACRLHPQGRPPALPTMIPAASSTPPGDALFPSVAPQDFWRSQVTG
10 20 30 40 50 60
40 50 60 70 80 90
pF1KE2 YSGSVTRHLSHRANNFKRHPKRRKCIRPSPPPPPNTPCPLELVDFGDLHPQRSFRELLFN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YSGSVTRHLSHRANNFKRHPKRRKCIRPSPPPPPNTPCPLELVDFGDLHPQRSFRELLFN
70 80 90 100 110 120
100 110 120 130 140 150
pF1KE2 GCILFGIEFSYAMETAYVTPVLLQMGLPDQLYSLVWFISPILGFLLQPLLGAWSDRCTSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GCILFGIEFSYAMETAYVTPVLLQMGLPDQLYSLVWFISPILGFLLQPLLGAWSDRCTSR
130 140 150 160 170 180
160 170 180 190 200 210
pF1KE2 FGRRRPFILVLAIGALLGLSLLLNGRDIGIALADVTGNHKWGLLLTVCGVVLMDFSADSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FGRRRPFILVLAIGALLGLSLLLNGRDIGIALADVTGNHKWGLLLTVCGVVLMDFSADSA
190 200 210 220 230 240
220 230 240 250 260 270
pF1KE2 DNPSHAYMMDVCSPADQDRGLNIHALLAGLGGGFGYVVGGIHWDKTGFGRALGGQLRVIY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DNPSHAYMMDVCSPADQDRGLNIHALLAGLGGGFGYVVGGIHWDKTGFGRALGGQLRVIY
250 260 270 280 290 300
280 290 300 310 320 330
pF1KE2 LFTAVTLSVTTVLTLVSIPERPLRPPSEKRAAMKSPSLPLPPSPPVLPEEGPGDSLPSHT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LFTAVTLSVTTVLTLVSIPERPLRPPSEKRAAMKSPSLPLPPSPPVLPEEGPGDSLPSHT
310 320 330 340 350 360
340 350 360 370 380 390
pF1KE2 ATNFSSPISPPSPLTPKYGSFISRDSSLTGISEFASSFGTANIDSVLIDCFTGGHDSYLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ATNFSSPISPPSPLTPKYGSFISRDSSLTGISEFASSFGTANIDSVLIDCFTGGHDSYLA
370 380 390 400 410 420
400 410 420 430 440 450
pF1KE2 IPGSVPRPPISVSFPRAPDGFYRQDRGLLEGREGALTSGCDGDILRVGSLDTSKPRSSGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IPGSVPRPPISVSFPRAPDGFYRQDRGLLEGREGALTSGCDGDILRVGSLDTSKPRSSGI
430 440 450 460 470 480
460 470 480 490 500 510
pF1KE2 LKRPQTLAIPDAAGGGGPETSRRRNVTFSQQVANILLNGVKYESELTGSSERAEQPLSVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LKRPQTLAIPDAAGGGGPETSRRRNVTFSQQVANILLNGVKYESELTGSSERAEQPLSVG
490 500 510 520 530 540
520 530 540 550 560 570
pF1KE2 RLCSTICNMPKALRTLCVNHFLGWLSFEGMLLFYTDFMGEVVFQGDPKAPHTSEAYQKYN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RLCSTICNMPKALRTLCVNHFLGWLSFEGMLLFYTDFMGEVVFQGDPKAPHTSEAYQKYN
550 560 570 580 590 600
580 590 600 610 620 630
pF1KE2 SGVTMGCWGMCIYAFSAAFYSAILEKLEEFLSVRTLYFIAYLAFGLGTGLATLSRNLYVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SGVTMGCWGMCIYAFSAAFYSAILEKLEEFLSVRTLYFIAYLAFGLGTGLATLSRNLYVV
610 620 630 640 650 660
640 650 660 670 680 690
pF1KE2 LSLCITYGILFSTLCTLPYSLLCDYYQSKKFAGSSADGTRRGMGVDISLLSCQYFLAQIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LSLCITYGILFSTLCTLPYSLLCDYYQSKKFAGSSADGTRRGMGVDISLLSCQYFLAQIL
670 680 690 700 710 720
700 710 720 730 740
pF1KE2 VSLVLGPLTSAVGSANGVMYFSSLVSFLGCLYSSLFVIYEIPPSDAADEEHRPLLLNV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VSLVLGPLTSAVGSANGVMYFSSLVSFLGCLYSSLFVIYEIPPSDAADEEHRPLLLNV
730 740 750 760 770 780
>>XP_011539832 (OMIM: 605763) PREDICTED: proton-associat (790 aa)
initn: 3637 init1: 3637 opt: 5027 Z-score: 3660.6 bits: 688.1 E(85289): 3.7e-197
Smith-Waterman score: 5027; 98.9% identity (98.9% similar) in 756 aa overlap (1-748:35-790)
10 20 30
pF1KE2 MIPAASSTPPGDALFPSVAPQDFWRSQVTG
::::::::::::::::::::::::::::::
XP_011 PGPRPGRQQPSGDRDACRLHPQGRPPALPTMIPAASSTPPGDALFPSVAPQDFWRSQVTG
10 20 30 40 50 60
40 50 60 70 80 90
pF1KE2 YSGSVTRHLSHRANNFKRHPKRRKCIRPSPPPPPNTPCPLELVDFGDLHPQRSFRELLFN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YSGSVTRHLSHRANNFKRHPKRRKCIRPSPPPPPNTPCPLELVDFGDLHPQRSFRELLFN
70 80 90 100 110 120
100 110 120 130 140 150
pF1KE2 GCILFGIEFSYAMETAYVTPVLLQMGLPDQLYSLVWFISPILGFLLQPLLGAWSDRCTSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GCILFGIEFSYAMETAYVTPVLLQMGLPDQLYSLVWFISPILGFLLQPLLGAWSDRCTSR
130 140 150 160 170 180
160 170 180 190 200 210
pF1KE2 FGRRRPFILVLAIGALLGLSLLLNGRDIGIALADVTGNHKWGLLLTVCGVVLMDFSADSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FGRRRPFILVLAIGALLGLSLLLNGRDIGIALADVTGNHKWGLLLTVCGVVLMDFSADSA
190 200 210 220 230 240
220 230 240 250 260 270
pF1KE2 DNPSHAYMMDVCSPADQDRGLNIHALLAGLGGGFGYVVGGIHWDKTGFGRALGGQLRVIY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DNPSHAYMMDVCSPADQDRGLNIHALLAGLGGGFGYVVGGIHWDKTGFGRALGGQLRVIY
250 260 270 280 290 300
280 290 300 310 320 330
pF1KE2 LFTAVTLSVTTVLTLVSIPERPLRPPSEKRAAMKSPSLPLPPSPPVLPEEGPGDSLPSHT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LFTAVTLSVTTVLTLVSIPERPLRPPSEKRAAMKSPSLPLPPSPPVLPEEGPGDSLPSHT
310 320 330 340 350 360
340 350 360 370 380 390
pF1KE2 ATNFSSPISPPSPLTPKYGSFISRDSSLTGISEFASSFGTANIDSVLIDCFTGGHDSYLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ATNFSSPISPPSPLTPKYGSFISRDSSLTGISEFASSFGTANIDSVLIDCFTGGHDSYLA
370 380 390 400 410 420
400 410 420 430 440 450
pF1KE2 IPGSVPRPPISVSFPRAPDGFYRQDRGLLEGREGALTSGCDGDILRVGSLDTSKPRSSGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IPGSVPRPPISVSFPRAPDGFYRQDRGLLEGREGALTSGCDGDILRVGSLDTSKPRSSGI
430 440 450 460 470 480
460 470 480 490 500 510
pF1KE2 LKRPQTLAIPDAAGGGGPETSRRRNVTFSQQVANILLNGVKYESELTGSSERAEQPLSVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LKRPQTLAIPDAAGGGGPETSRRRNVTFSQQVANILLNGVKYESELTGSSERAEQPLSVG
490 500 510 520 530 540
520 530 540 550 560
pF1KE2 RLCSTICNMPKALRTLCVNHFLG--------WLSFEGMLLFYTDFMGEVVFQGDPKAPHT
::::::::::::::::::::::: :::::::::::::::::::::::::::::
XP_011 RLCSTICNMPKALRTLCVNHFLGELPAKPPRWLSFEGMLLFYTDFMGEVVFQGDPKAPHT
550 560 570 580 590 600
570 580 590 600 610 620
pF1KE2 SEAYQKYNSGVTMGCWGMCIYAFSAAFYSAILEKLEEFLSVRTLYFIAYLAFGLGTGLAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SEAYQKYNSGVTMGCWGMCIYAFSAAFYSAILEKLEEFLSVRTLYFIAYLAFGLGTGLAT
610 620 630 640 650 660
630 640 650 660 670 680
pF1KE2 LSRNLYVVLSLCITYGILFSTLCTLPYSLLCDYYQSKKFAGSSADGTRRGMGVDISLLSC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LSRNLYVVLSLCITYGILFSTLCTLPYSLLCDYYQSKKFAGSSADGTRRGMGVDISLLSC
670 680 690 700 710 720
690 700 710 720 730 740
pF1KE2 QYFLAQILVSLVLGPLTSAVGSANGVMYFSSLVSFLGCLYSSLFVIYEIPPSDAADEEHR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QYFLAQILVSLVLGPLTSAVGSANGVMYFSSLVSFLGCLYSSLFVIYEIPPSDAADEEHR
730 740 750 760 770 780
pF1KE2 PLLLNV
::::::
XP_011 PLLLNV
790
>>XP_011539833 (OMIM: 605763) PREDICTED: proton-associat (759 aa)
initn: 2485 init1: 2485 opt: 3875 Z-score: 2824.3 bits: 533.3 E(85289): 1.4e-150
Smith-Waterman score: 4739; 94.8% identity (94.8% similar) in 756 aa overlap (1-748:35-759)
10 20 30
pF1KE2 MIPAASSTPPGDALFPSVAPQDFWRSQVTG
::::::::::::::::::::::::::::::
XP_011 PGPRPGRQQPSGDRDACRLHPQGRPPALPTMIPAASSTPPGDALFPSVAPQDFWRSQVTG
10 20 30 40 50 60
40 50 60 70 80 90
pF1KE2 YSGSVTRHLSHRANNFKRHPKRRKCIRPSPPPPPNTPCPLELVDFGDLHPQRSFRELLFN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YSGSVTRHLSHRANNFKRHPKRRKCIRPSPPPPPNTPCPLELVDFGDLHPQRSFRELLFN
70 80 90 100 110 120
100 110 120 130 140 150
pF1KE2 GCILFGIEFSYAMETAYVTPVLLQMGLPDQLYSLVWFISPILGFLLQPLLGAWSDRCTSR
:::::::::::::::::::::::::::::::::::::::::::
XP_011 GCILFGIEFSYAMETAYVTPVLLQMGLPDQLYSLVWFISPILG-----------------
130 140 150 160
160 170 180 190 200 210
pF1KE2 FGRRRPFILVLAIGALLGLSLLLNGRDIGIALADVTGNHKWGLLLTVCGVVLMDFSADSA
::::::::::::::::::::::::::::::::::::::::::::::
XP_011 --------------ALLGLSLLLNGRDIGIALADVTGNHKWGLLLTVCGVVLMDFSADSA
170 180 190 200 210
220 230 240 250 260 270
pF1KE2 DNPSHAYMMDVCSPADQDRGLNIHALLAGLGGGFGYVVGGIHWDKTGFGRALGGQLRVIY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DNPSHAYMMDVCSPADQDRGLNIHALLAGLGGGFGYVVGGIHWDKTGFGRALGGQLRVIY
220 230 240 250 260 270
280 290 300 310 320 330
pF1KE2 LFTAVTLSVTTVLTLVSIPERPLRPPSEKRAAMKSPSLPLPPSPPVLPEEGPGDSLPSHT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LFTAVTLSVTTVLTLVSIPERPLRPPSEKRAAMKSPSLPLPPSPPVLPEEGPGDSLPSHT
280 290 300 310 320 330
340 350 360 370 380 390
pF1KE2 ATNFSSPISPPSPLTPKYGSFISRDSSLTGISEFASSFGTANIDSVLIDCFTGGHDSYLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ATNFSSPISPPSPLTPKYGSFISRDSSLTGISEFASSFGTANIDSVLIDCFTGGHDSYLA
340 350 360 370 380 390
400 410 420 430 440 450
pF1KE2 IPGSVPRPPISVSFPRAPDGFYRQDRGLLEGREGALTSGCDGDILRVGSLDTSKPRSSGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IPGSVPRPPISVSFPRAPDGFYRQDRGLLEGREGALTSGCDGDILRVGSLDTSKPRSSGI
400 410 420 430 440 450
460 470 480 490 500 510
pF1KE2 LKRPQTLAIPDAAGGGGPETSRRRNVTFSQQVANILLNGVKYESELTGSSERAEQPLSVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LKRPQTLAIPDAAGGGGPETSRRRNVTFSQQVANILLNGVKYESELTGSSERAEQPLSVG
460 470 480 490 500 510
520 530 540 550 560
pF1KE2 RLCSTICNMPKALRTLCVNHFLG--------WLSFEGMLLFYTDFMGEVVFQGDPKAPHT
::::::::::::::::::::::: :::::::::::::::::::::::::::::
XP_011 RLCSTICNMPKALRTLCVNHFLGELPAKPPRWLSFEGMLLFYTDFMGEVVFQGDPKAPHT
520 530 540 550 560 570
570 580 590 600 610 620
pF1KE2 SEAYQKYNSGVTMGCWGMCIYAFSAAFYSAILEKLEEFLSVRTLYFIAYLAFGLGTGLAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SEAYQKYNSGVTMGCWGMCIYAFSAAFYSAILEKLEEFLSVRTLYFIAYLAFGLGTGLAT
580 590 600 610 620 630
630 640 650 660 670 680
pF1KE2 LSRNLYVVLSLCITYGILFSTLCTLPYSLLCDYYQSKKFAGSSADGTRRGMGVDISLLSC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LSRNLYVVLSLCITYGILFSTLCTLPYSLLCDYYQSKKFAGSSADGTRRGMGVDISLLSC
640 650 660 670 680 690
690 700 710 720 730 740
pF1KE2 QYFLAQILVSLVLGPLTSAVGSANGVMYFSSLVSFLGCLYSSLFVIYEIPPSDAADEEHR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QYFLAQILVSLVLGPLTSAVGSANGVMYFSSLVSFLGCLYSSLFVIYEIPPSDAADEEHR
700 710 720 730 740 750
pF1KE2 PLLLNV
::::::
XP_011 PLLLNV
>>NP_057264 (OMIM: 227240,606202,606574) membrane-associ (530 aa)
initn: 1317 init1: 461 opt: 615 Z-score: 459.4 bits: 95.2 E(85289): 7.6e-19
Smith-Waterman score: 1088; 32.5% identity (57.3% similar) in 656 aa overlap (80-729:28-528)
50 60 70 80 90 100
pF1KE2 PKRRKCIRPSPPPPPNTPCPLELVDFGDLHPQRSFRELLFNGCILFGIEFSYAMETAYVT
:.: .:.... .:: :: ::.:.::::
NP_057 MGSNSGQAGRHIYKSLADDGPFDSVEPPKRPTSRLIMHSMAMFGREFCYAVEAAYVT
10 20 30 40 50
110 120 130 140 150 160
pF1KE2 PVLLQMGLPDQLYSLVWFISPILGFLLQPLLGAWSDRCTSRFGRRRPFILVLAIGALLGL
::::..:::..:::.:::.::::::::::..:. ::.: ::.:::::.::.:.. :.:.
NP_057 PVLLSVGLPSSLYSIVWFLSPILGFLLQPVVGSASDHCRSRWGRRRPYILTLGVMMLVGM
60 70 80 90 100 110
170 180 190 200 210 220
pF1KE2 SLLLNGRDIGIAL-ADVTGNHKWGLLLTVCGVVLMDFSADSADNPSHAYMMDVCSPADQD
.: ::: . :: :. . :.. .:. ::::.::.:: :.: .::..:::: :..
NP_057 ALYLNGATVVAALIANPRRKLVWAISVTMIGVVLFDFAADFIDGPIKAYLFDVCSHQDKE
120 130 140 150 160 170
230 240 250 260 270 280
pF1KE2 RGLNIHALLAGLGGGFGYVVGGIHWDKTGFGRALGGQLRVIYLFTAVTLSVTTVLTLVSI
.::. :::..:.::..::..:.: : . .:: :: ...:...:.:..:.. .. : ::
NP_057 KGLHYHALFTGFGGALGYLLGAIDWAHLELGRLLGTEFQVMFFFSALVLTLCFTVHLCSI
180 190 200 210 220 230
290 300 310 320 330 340
pF1KE2 PERPLRPPSEKRAAMKSPSLPLPPSPPVLPEEGPGDSLPSHTATNFSSPISPPSPLTPKY
: :: .. ..: :.. : :
NP_057 SEAPLTEVAK--------GIP--------PQQTPQD------------------------
240 250
350 360 370 380 390 400
pF1KE2 GSFISRDSSLTGISEFASSFGTANIDSVLIDCFTGGHDSYLAIPGSVPRPPISVSFPRAP
::.:
NP_057 -------------------------------------------------PPLS------S
260
410 420 430 440 450 460
pF1KE2 DGFYRQDRGLLEGREGALTSGCDGDILRVGSLDTSKPRSSGILKRPQTLAIPDAAGGGGP
::.:. ::.. : : .:
NP_057 DGMYEY-----------------------GSIEKVK------------------NGYVNP
270 280
470 480 490 500 510 520
pF1KE2 ETSRRRNVTFSQQVANILLNGVKYESELTGSSERAEQPLSVGRLCSTICNMPKALRTLCV
: . ..:.: ... .:.... ... : .. ::: : ::.
NP_057 ELA---------------MQGAKNKNH----AEQTRRAMTLKSLLRALVNMPPHYRYLCI
290 300 310 320
530 540 550 560 570 580
pF1KE2 NHFLGWLSFEGMLLFYTDFMGEVVFQGDPKAPHTSEAYQKYNSGVTMGCWGMCIYAFSAA
.:..:: .: . .::.:::::..:..::: . :.: . :. :: .::::.:: . ..
NP_057 SHLIGWTAFLSNMLFFTDFMGQIVYRGDPYSAHNSTEFLIYERGVEVGCWGFCINSVFSS
330 340 350 360 370 380
590 600 610 620 630 640
pF1KE2 FYSAILEKLEEFLSVRTLYFIAYLAFGLGTGLATLSRNLYVVLSLCITYGILFSTLCTLP
.:: . . : ..... ::: .:: ::::::. : :.: .: :: .:.. ::: :.:
NP_057 LYSYFQKVLVSYIGLKGLYFTGYLLFGLGTGFIGLFPNVYSTLVLCSLFGVMSSTLYTVP
390 400 410 420 430 440
650 660 670 680 690 700
pF1KE2 YSLLCDYY-----QSKKFAGSSADGTRRGMGVDISLLSCQYFLAQILVSLVLGPLTSAVG
..:. .:. . .. :.. :.. :: :.: . :.:. ::::::. :: :....:
NP_057 FNLITEYHREEEKERQQAPGGDPDNSVRGKGMDCATLTCMVQLAQILVGGGLGFLVNTAG
450 460 470 480 490 500
710 720 730 740
pF1KE2 SANGVMYFSSLVSFLGCLYSSLFVIYEIPPSDAADEEHRPLLLNV
.. :. .: :...:: . .::: :
NP_057 TVVVVVITASAVALIGCCFVALFVRYVD
510 520 530
>>NP_001284346 (OMIM: 227240,606202,606574) membrane-ass (243 aa)
initn: 553 init1: 410 opt: 570 Z-score: 432.0 bits: 89.0 E(85289): 2.5e-17
Smith-Waterman score: 570; 51.8% identity (79.9% similar) in 164 aa overlap (80-242:28-191)
50 60 70 80 90 100
pF1KE2 PKRRKCIRPSPPPPPNTPCPLELVDFGDLHPQRSFRELLFNGCILFGIEFSYAMETAYVT
:.: .:.... .:: :: ::.:.::::
NP_001 MGSNSGQAGRHIYKSLADDGPFDSVEPPKRPTSRLIMHSMAMFGREFCYAVEAAYVT
10 20 30 40 50
110 120 130 140 150 160
pF1KE2 PVLLQMGLPDQLYSLVWFISPILGFLLQPLLGAWSDRCTSRFGRRRPFILVLAIGALLGL
::::..:::..:::.:::.::::::::::..:. ::.: ::.:::::.::.:.. :.:.
NP_001 PVLLSVGLPSSLYSIVWFLSPILGFLLQPVVGSASDHCRSRWGRRRPYILTLGVMMLVGM
60 70 80 90 100 110
170 180 190 200 210 220
pF1KE2 SLLLNGRDIGIAL-ADVTGNHKWGLLLTVCGVVLMDFSADSADNPSHAYMMDVCSPADQD
.: ::: . :: :. . :.. .:. ::::.::.:: :.: .::..:::: :..
NP_001 ALYLNGATVVAALIANPRRKLVWAISVTMIGVVLFDFAADFIDGPIKAYLFDVCSHQDKE
120 130 140 150 160 170
230 240 250 260 270 280
pF1KE2 RGLNIHALLAGLGGGFGYVVGGIHWDKTGFGRALGGQLRVIYLFTAVTLSVTTVLTLVSI
.::. :::.. :
NP_001 KGLHYHALFTDSQGNDIKVTAESTGEHASSLPLPLHQPPHWMDSLPVQHAVLHRFHGPDC
180 190 200 210 220 230
>>NP_001012527 (OMIM: 227240,606202,606574) membrane-ass (460 aa)
initn: 1186 init1: 461 opt: 477 Z-score: 360.1 bits: 76.6 E(85289): 2.6e-13
Smith-Waterman score: 950; 32.0% identity (56.2% similar) in 582 aa overlap (80-660:28-454)
50 60 70 80 90 100
pF1KE2 PKRRKCIRPSPPPPPNTPCPLELVDFGDLHPQRSFRELLFNGCILFGIEFSYAMETAYVT
:.: .:.... .:: :: ::.:.::::
NP_001 MGSNSGQAGRHIYKSLADDGPFDSVEPPKRPTSRLIMHSMAMFGREFCYAVEAAYVT
10 20 30 40 50
110 120 130 140 150 160
pF1KE2 PVLLQMGLPDQLYSLVWFISPILGFLLQPLLGAWSDRCTSRFGRRRPFILVLAIGALLGL
::::..:::..:::.:::.::::::::::..:. ::.: ::.:::::.::.:.. :.:.
NP_001 PVLLSVGLPSSLYSIVWFLSPILGFLLQPVVGSASDHCRSRWGRRRPYILTLGVMMLVGM
60 70 80 90 100 110
170 180 190 200 210 220
pF1KE2 SLLLNGRDIGIAL-ADVTGNHKWGLLLTVCGVVLMDFSADSADNPSHAYMMDVCSPADQD
.: ::: . :: :. . :.. .:. ::::.::.:: :.: .::..:::: :..
NP_001 ALYLNGATVVAALIANPRRKLVWAISVTMIGVVLFDFAADFIDGPIKAYLFDVCSHQDKE
120 130 140 150 160 170
230 240 250 260 270 280
pF1KE2 RGLNIHALLAGLGGGFGYVVGGIHWDKTGFGRALGGQLRVIYLFTAVTLSVTTVLTLVSI
.::. :::..:.::..::..:.: : . .:: :: ...:...:.:..:.. .. : ::
NP_001 KGLHYHALFTGFGGALGYLLGAIDWAHLELGRLLGTEFQVMFFFSALVLTLCFTVHLCSI
180 190 200 210 220 230
290 300 310 320 330 340
pF1KE2 PERPLRPPSEKRAAMKSPSLPLPPSPPVLPEEGPGDSLPSHTATNFSSPISPPSPLTPKY
: :: .. ..: :.. : :
NP_001 SEAPLTEVAK--------GIP--------PQQTPQD------------------------
240 250
350 360 370 380 390 400
pF1KE2 GSFISRDSSLTGISEFASSFGTANIDSVLIDCFTGGHDSYLAIPGSVPRPPISVSFPRAP
::.:
NP_001 -------------------------------------------------PPLS------S
260
410 420 430 440 450 460
pF1KE2 DGFYRQDRGLLEGREGALTSGCDGDILRVGSLDTSKPRSSGILKRPQTLAIPDAAGGGGP
::.:. ::.. : : .:
NP_001 DGMYEY-----------------------GSIEKVK------------------NGYVNP
270 280
470 480 490 500 510 520
pF1KE2 ETSRRRNVTFSQQVANILLNGVKYESELTGSSERAEQPLSVGRLCSTICNMPKALRTLCV
: . ..:.: ... .:.... ... : .. ::: : ::.
NP_001 ELA---------------MQGAKNKNH----AEQTRRAMTLKSLLRALVNMPPHYRYLCI
290 300 310 320
530 540 550 560 570 580
pF1KE2 NHFLGWLSFEGMLLFYTDFMGEVVFQGDPKAPHTSEAYQKYNSGVTMGCWGMCIYAFSAA
.:..:: .: . .::.:::::..:..::: . :.: . :. :: .::::.:: . ..
NP_001 SHLIGWTAFLSNMLFFTDFMGQIVYRGDPYSAHNSTEFLIYERGVEVGCWGFCINSVFSS
330 340 350 360 370 380
590 600 610 620 630 640
pF1KE2 FYSAILEKLEEFLSVRTLYFIAYLAFGLGTGLATLSRNLYVVLSLCITYGILFSTLCTLP
.:: . . : ..... ::: .:: ::::::. : :.: .: :: .:.. ::: :.:
NP_001 LYSYFQKVLVSYIGLKGLYFTGYLLFGLGTGFIGLFPNVYSTLVLCSLFGVMSSTLYTVP
390 400 410 420 430 440
650 660 670 680 690 700
pF1KE2 YSLLCDYYQSKKFAGSSADGTRRGMGVDISLLSCQYFLAQILVSLVLGPLTSAVGSANGV
..:. .:.. ..
NP_001 FNLITEYHREEEKEVCCH
450 460
>>XP_005245617 (OMIM: 605097) PREDICTED: solute carrier (328 aa)
initn: 491 init1: 240 opt: 393 Z-score: 301.4 bits: 65.3 E(85289): 4.8e-10
Smith-Waterman score: 393; 33.1% identity (63.1% similar) in 236 aa overlap (86-318:17-243)
60 70 80 90 100 110
pF1KE2 IRPSPPPPPNTPCPLELVDFGDLHPQRSFRELLFNGCILFGIEFSYAMETAYVTPVLLQM
.::. . . ::.: : .:: :.::..
XP_005 MVQRLWVSRLLRHRKAQLLLVNLLTFGLEVCLAAGITYVPPLLLEV
10 20 30 40
120 130 140 150 160 170
pF1KE2 GLPDQLYSLVWFISPILGFLLQPLLGAWSDRCTSRFGRRRPFILVLAIGALLGLSLL-LN
:. ......: :.:.::.. ::::. ::. .:.::::::: .:..: ::.: :.
XP_005 GVEEKFMTMVLGIGPVLGLVCVPLLGSASDHWRGRYGRRRPFIWALSLGILLSLFLIPRA
50 60 70 80 90 100
180 190 200 210 220 230
pF1KE2 GRDIGIALADVTGNHKWGLLLTVCGVVLMDFSADSADNPSHAYMMDVCSPADQDR-GLNI
: :. : . : : . :: :.:: .. .: .: . :. :. : . ..
XP_005 GWLAGLLCPD---PRPLELALLILGVGLLDFCGQVCFTPLEALLSDLFRDPDHCRQAYSV
110 120 130 140 150 160
240 250 260 270 280 290
pF1KE2 HALLAGLGGGFGYVVGGIHWDKTGFGRALGGQLRVIY-LFTAVTLSVTTVLTLVSIPERP
.:.. .::: .::.. .: :: .... :: : . .. :.: . :. ... ::. :.
XP_005 YAFMISLGGCLGYLLPAIDWDTSALAPYLGTQEECLFGLLTLIFLTCVAATLLVA--EEA
170 180 190 200 210 220
300 310 320 330 340 350
pF1KE2 LRPPSEKRAAMKSPSLPLPPSPPVLPEEGPGDSLPSHTATNFSSPISPPSPLTPKYGSFI
:.: ....::: :: :
XP_005 ALGPTEPAEGLSAPSL----SPHCCPCRARLAFRNLGALLPRLHQLCCRMPRTLRRLFVA
230 240 250 260 270
>>XP_016858127 (OMIM: 605097) PREDICTED: solute carrier (553 aa)
initn: 637 init1: 333 opt: 333 Z-score: 254.3 bits: 57.3 E(85289): 2e-07
Smith-Waterman score: 393; 33.1% identity (63.1% similar) in 236 aa overlap (86-318:17-243)
60 70 80 90 100 110
pF1KE2 IRPSPPPPPNTPCPLELVDFGDLHPQRSFRELLFNGCILFGIEFSYAMETAYVTPVLLQM
.::. . . ::.: : .:: :.::..
XP_016 MVQRLWVSRLLRHRKAQLLLVNLLTFGLEVCLAAGITYVPPLLLEV
10 20 30 40
120 130 140 150 160 170
pF1KE2 GLPDQLYSLVWFISPILGFLLQPLLGAWSDRCTSRFGRRRPFILVLAIGALLGLSLL-LN
:. ......: :.:.::.. ::::. ::. .:.::::::: .:..: ::.: :.
XP_016 GVEEKFMTMVLGIGPVLGLVCVPLLGSASDHWRGRYGRRRPFIWALSLGILLSLFLIPRA
50 60 70 80 90 100
180 190 200 210 220 230
pF1KE2 GRDIGIALADVTGNHKWGLLLTVCGVVLMDFSADSADNPSHAYMMDVCSPADQDR-GLNI
: :. : . : : . :: :.:: .. .: .: . :. :. : . ..
XP_016 GWLAGLLCPD---PRPLELALLILGVGLLDFCGQVCFTPLEALLSDLFRDPDHCRQAYSV
110 120 130 140 150 160
240 250 260 270 280 290
pF1KE2 HALLAGLGGGFGYVVGGIHWDKTGFGRALGGQLRVIY-LFTAVTLSVTTVLTLVSIPERP
.:.. .::: .::.. .: :: .... :: : . .. :.: . :. ... ::. :.
XP_016 YAFMISLGGCLGYLLPAIDWDTSALAPYLGTQEECLFGLLTLIFLTCVAATLLVA--EEA
170 180 190 200 210 220
300 310 320 330 340 350
pF1KE2 LRPPSEKRAAMKSPSLPLPPSPPVLPEEGPGDSLPSHTATNFSSPISPPSPLTPKYGSFI
:.: ....::: :: :
XP_016 ALGPTEPAEGLSAPSL----SPHCCPCRARLAFRNLGALLPRLHQLCCRMPRTLRRLFVA
230 240 250 260 270
>--
initn: 371 init1: 333 opt: 333 Z-score: 254.3 bits: 57.3 E(85289): 2e-07
Smith-Waterman score: 333; 32.2% identity (63.2% similar) in 171 aa overlap (511-681:259-429)
490 500 510 520 530 540
pF1KE2 QVANILLNGVKYESELTGSSERAEQPLSVGRLCSTICNMPKALRTLCVNHFLGWLSFEGM
:: . : ::..:: : : .. .:... .
XP_016 AEGLSAPSLSPHCCPCRARLAFRNLGALLPRLHQLCCRMPRTLRRLFVAELCSWMALMTF
230 240 250 260 270 280
550 560 570 580 590 600
pF1KE2 LLFYTDFMGEVVFQGDPKAPHTSEAYQKYNSGVTMGCWGMCIYAFSAAFYSAILEKLEEF
::::::.:: ..:: :.: .:: ..:. :: :: :. . . .: ....: .
XP_016 TLFYTDFVGEGLYQGVPRAEPGTEARRHYDEGVRMGSLGLFLQCAISLVFSLVMDRLVQR
290 300 310 320 330 340
610 620 630 640 650 660
pF1KE2 LSVRTLYFIAYLAFGLGTGLATLSRNLYVVLSLCITYGILFSTLCTLPYSLLCDYYQSKK
...:..:. . :: ...: . ::... :: . :. ::.: :::.: :.. :.
XP_016 FGTRAVYLASVAAFPVAAGATCLSHSVAVVTASAALTGFTFSALQILPYTLASLYHREKQ
350 360 370 380 390 400
670 680 690 700 710 720
pF1KE2 FAGSSADGTRRGMGVDISLLSCQYFLAQILVSLVLGPLTSAVGSANGVMYFSSLVSFLGC
. : : . . ::..
XP_016 VFLPKYRGDTGGASSEDSLMTSFLPGPKPGAPFPNGHVGAGGSGLLPPPPALCGASACDV
410 420 430 440 450 460
>>NP_149093 (OMIM: 605097) solute carrier family 45 memb (553 aa)
initn: 637 init1: 333 opt: 333 Z-score: 254.3 bits: 57.3 E(85289): 2e-07
Smith-Waterman score: 393; 33.1% identity (63.1% similar) in 236 aa overlap (86-318:17-243)
60 70 80 90 100 110
pF1KE2 IRPSPPPPPNTPCPLELVDFGDLHPQRSFRELLFNGCILFGIEFSYAMETAYVTPVLLQM
.::. . . ::.: : .:: :.::..
NP_149 MVQRLWVSRLLRHRKAQLLLVNLLTFGLEVCLAAGITYVPPLLLEV
10 20 30 40
120 130 140 150 160 170
pF1KE2 GLPDQLYSLVWFISPILGFLLQPLLGAWSDRCTSRFGRRRPFILVLAIGALLGLSLL-LN
:. ......: :.:.::.. ::::. ::. .:.::::::: .:..: ::.: :.
NP_149 GVEEKFMTMVLGIGPVLGLVCVPLLGSASDHWRGRYGRRRPFIWALSLGILLSLFLIPRA
50 60 70 80 90 100
180 190 200 210 220 230
pF1KE2 GRDIGIALADVTGNHKWGLLLTVCGVVLMDFSADSADNPSHAYMMDVCSPADQDR-GLNI
: :. : . : : . :: :.:: .. .: .: . :. :. : . ..
NP_149 GWLAGLLCPD---PRPLELALLILGVGLLDFCGQVCFTPLEALLSDLFRDPDHCRQAYSV
110 120 130 140 150 160
240 250 260 270 280 290
pF1KE2 HALLAGLGGGFGYVVGGIHWDKTGFGRALGGQLRVIY-LFTAVTLSVTTVLTLVSIPERP
.:.. .::: .::.. .: :: .... :: : . .. :.: . :. ... ::. :.
NP_149 YAFMISLGGCLGYLLPAIDWDTSALAPYLGTQEECLFGLLTLIFLTCVAATLLVA--EEA
170 180 190 200 210 220
300 310 320 330 340 350
pF1KE2 LRPPSEKRAAMKSPSLPLPPSPPVLPEEGPGDSLPSHTATNFSSPISPPSPLTPKYGSFI
:.: ....::: :: :
NP_149 ALGPTEPAEGLSAPSL----SPHCCPCRARLAFRNLGALLPRLHQLCCRMPRTLRRLFVA
230 240 250 260 270
>--
initn: 371 init1: 333 opt: 333 Z-score: 254.3 bits: 57.3 E(85289): 2e-07
Smith-Waterman score: 333; 32.2% identity (63.2% similar) in 171 aa overlap (511-681:259-429)
490 500 510 520 530 540
pF1KE2 QVANILLNGVKYESELTGSSERAEQPLSVGRLCSTICNMPKALRTLCVNHFLGWLSFEGM
:: . : ::..:: : : .. .:... .
NP_149 AEGLSAPSLSPHCCPCRARLAFRNLGALLPRLHQLCCRMPRTLRRLFVAELCSWMALMTF
230 240 250 260 270 280
550 560 570 580 590 600
pF1KE2 LLFYTDFMGEVVFQGDPKAPHTSEAYQKYNSGVTMGCWGMCIYAFSAAFYSAILEKLEEF
::::::.:: ..:: :.: .:: ..:. :: :: :. . . .: ....: .
NP_149 TLFYTDFVGEGLYQGVPRAEPGTEARRHYDEGVRMGSLGLFLQCAISLVFSLVMDRLVQR
290 300 310 320 330 340
610 620 630 640 650 660
pF1KE2 LSVRTLYFIAYLAFGLGTGLATLSRNLYVVLSLCITYGILFSTLCTLPYSLLCDYYQSKK
...:..:. . :: ...: . ::... :: . :. ::.: :::.: :.. :.
NP_149 FGTRAVYLASVAAFPVAAGATCLSHSVAVVTASAALTGFTFSALQILPYTLASLYHREKQ
350 360 370 380 390 400
670 680 690 700 710 720
pF1KE2 FAGSSADGTRRGMGVDISLLSCQYFLAQILVSLVLGPLTSAVGSANGVMYFSSLVSFLGC
. : : . . ::..
NP_149 VFLPKYRGDTGGASSEDSLMTSFLPGPKPGAPFPNGHVGAGGSGLLPPPPALCGASACDV
410 420 430 440 450 460
>>XP_005245613 (OMIM: 605097) PREDICTED: solute carrier (553 aa)
initn: 637 init1: 333 opt: 333 Z-score: 254.3 bits: 57.3 E(85289): 2e-07
Smith-Waterman score: 393; 33.1% identity (63.1% similar) in 236 aa overlap (86-318:17-243)
60 70 80 90 100 110
pF1KE2 IRPSPPPPPNTPCPLELVDFGDLHPQRSFRELLFNGCILFGIEFSYAMETAYVTPVLLQM
.::. . . ::.: : .:: :.::..
XP_005 MVQRLWVSRLLRHRKAQLLLVNLLTFGLEVCLAAGITYVPPLLLEV
10 20 30 40
120 130 140 150 160 170
pF1KE2 GLPDQLYSLVWFISPILGFLLQPLLGAWSDRCTSRFGRRRPFILVLAIGALLGLSLL-LN
:. ......: :.:.::.. ::::. ::. .:.::::::: .:..: ::.: :.
XP_005 GVEEKFMTMVLGIGPVLGLVCVPLLGSASDHWRGRYGRRRPFIWALSLGILLSLFLIPRA
50 60 70 80 90 100
180 190 200 210 220 230
pF1KE2 GRDIGIALADVTGNHKWGLLLTVCGVVLMDFSADSADNPSHAYMMDVCSPADQDR-GLNI
: :. : . : : . :: :.:: .. .: .: . :. :. : . ..
XP_005 GWLAGLLCPD---PRPLELALLILGVGLLDFCGQVCFTPLEALLSDLFRDPDHCRQAYSV
110 120 130 140 150 160
240 250 260 270 280 290
pF1KE2 HALLAGLGGGFGYVVGGIHWDKTGFGRALGGQLRVIY-LFTAVTLSVTTVLTLVSIPERP
.:.. .::: .::.. .: :: .... :: : . .. :.: . :. ... ::. :.
XP_005 YAFMISLGGCLGYLLPAIDWDTSALAPYLGTQEECLFGLLTLIFLTCVAATLLVA--EEA
170 180 190 200 210 220
300 310 320 330 340 350
pF1KE2 LRPPSEKRAAMKSPSLPLPPSPPVLPEEGPGDSLPSHTATNFSSPISPPSPLTPKYGSFI
:.: ....::: :: :
XP_005 ALGPTEPAEGLSAPSL----SPHCCPCRARLAFRNLGALLPRLHQLCCRMPRTLRRLFVA
230 240 250 260 270
>--
initn: 371 init1: 333 opt: 333 Z-score: 254.3 bits: 57.3 E(85289): 2e-07
Smith-Waterman score: 333; 32.2% identity (63.2% similar) in 171 aa overlap (511-681:259-429)
490 500 510 520 530 540
pF1KE2 QVANILLNGVKYESELTGSSERAEQPLSVGRLCSTICNMPKALRTLCVNHFLGWLSFEGM
:: . : ::..:: : : .. .:... .
XP_005 AEGLSAPSLSPHCCPCRARLAFRNLGALLPRLHQLCCRMPRTLRRLFVAELCSWMALMTF
230 240 250 260 270 280
550 560 570 580 590 600
pF1KE2 LLFYTDFMGEVVFQGDPKAPHTSEAYQKYNSGVTMGCWGMCIYAFSAAFYSAILEKLEEF
::::::.:: ..:: :.: .:: ..:. :: :: :. . . .: ....: .
XP_005 TLFYTDFVGEGLYQGVPRAEPGTEARRHYDEGVRMGSLGLFLQCAISLVFSLVMDRLVQR
290 300 310 320 330 340
610 620 630 640 650 660
pF1KE2 LSVRTLYFIAYLAFGLGTGLATLSRNLYVVLSLCITYGILFSTLCTLPYSLLCDYYQSKK
...:..:. . :: ...: . ::... :: . :. ::.: :::.: :.. :.
XP_005 FGTRAVYLASVAAFPVAAGATCLSHSVAVVTASAALTGFTFSALQILPYTLASLYHREKQ
350 360 370 380 390 400
670 680 690 700 710 720
pF1KE2 FAGSSADGTRRGMGVDISLLSCQYFLAQILVSLVLGPLTSAVGSANGVMYFSSLVSFLGC
. : : . . ::..
XP_005 VFLPKYRGDTGGASSEDSLMTSFLPGPKPGAPFPNGHVGAGGSGLLPPPPALCGASACDV
410 420 430 440 450 460
748 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 19:53:47 2016 done: Mon Nov 7 19:53:49 2016
Total Scan time: 13.080 Total Display time: 0.100
Function used was FASTA [36.3.4 Apr, 2011]