FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE3044, 183 aa 1>>>pF1KE3044 183 - 183 aa - 183 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.1826+/-0.000944; mu= 13.7218+/- 0.057 mean_var=83.8883+/-17.446, 0's: 0 Z-trim(107.0): 195 B-trim: 271 in 1/50 Lambda= 0.140031 statistics sampled from 9094 (9317) to 9094 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.679), E-opt: 0.2 (0.286), width: 16 Scan time: 1.730 The best scores are: opt bits E(32554) CCDS14632.1 RAP2C gene_id:57826|Hs108|chrX ( 183) 1193 250.5 4.4e-67 CCDS9485.1 RAP2A gene_id:5911|Hs108|chr13 ( 183) 1109 233.5 5.6e-62 CCDS3170.1 RAP2B gene_id:5912|Hs108|chr3 ( 183) 1050 221.6 2.2e-58 CCDS76024.1 RAP2C gene_id:57826|Hs108|chrX ( 117) 781 167.0 3.6e-42 CCDS840.1 RAP1A gene_id:5906|Hs108|chr1 ( 184) 744 159.7 8.9e-40 CCDS8984.1 RAP1B gene_id:5908|Hs108|chr12 ( 184) 731 157.1 5.5e-39 CCDS8702.1 KRAS gene_id:3845|Hs108|chr12 ( 188) 583 127.2 5.6e-30 CCDS8703.1 KRAS gene_id:3845|Hs108|chr12 ( 189) 581 126.8 7.4e-30 CCDS7698.1 HRAS gene_id:3265|Hs108|chr11 ( 189) 578 126.2 1.1e-29 CCDS877.1 NRAS gene_id:4893|Hs108|chr1 ( 189) 574 125.4 2e-29 CCDS1123.1 RIT1 gene_id:6016|Hs108|chr1 ( 219) 574 125.5 2.2e-29 CCDS58037.1 RIT1 gene_id:6016|Hs108|chr1 ( 236) 574 125.5 2.3e-29 CCDS11921.1 RIT2 gene_id:6014|Hs108|chr18 ( 217) 568 124.3 5.1e-29 CCDS2131.1 RALB gene_id:5899|Hs108|chr2 ( 206) 549 120.4 7e-28 CCDS6687.1 DIRAS2 gene_id:54769|Hs108|chr9 ( 199) 541 118.8 2.1e-27 CCDS7699.1 HRAS gene_id:3265|Hs108|chr11 ( 170) 534 117.3 5e-27 CCDS7814.1 RRAS2 gene_id:22800|Hs108|chr11 ( 204) 530 116.6 9.9e-27 CCDS5460.1 RALA gene_id:5898|Hs108|chr7 ( 206) 521 114.7 3.5e-26 CCDS3100.1 MRAS gene_id:22808|Hs108|chr3 ( 208) 518 114.1 5.4e-26 CCDS12092.1 DIRAS1 gene_id:148252|Hs108|chr19 ( 198) 511 112.7 1.4e-25 CCDS12774.1 RRAS gene_id:6237|Hs108|chr19 ( 218) 507 111.9 2.6e-25 CCDS58036.1 RIT1 gene_id:6016|Hs108|chr1 ( 183) 481 106.6 8.8e-24 CCDS62431.1 RIT2 gene_id:6014|Hs108|chr18 ( 153) 459 102.1 1.7e-22 CCDS8673.1 RERG gene_id:85004|Hs108|chr12 ( 199) 437 97.8 4.4e-21 CCDS8778.1 RHEBL1 gene_id:121268|Hs108|chr12 ( 183) 433 96.9 7.3e-21 CCDS53603.1 RRAS2 gene_id:22800|Hs108|chr11 ( 169) 423 94.9 2.8e-20 CCDS58253.1 RAP1B gene_id:5908|Hs108|chr12 ( 165) 419 94.0 4.8e-20 CCDS58254.1 RAP1B gene_id:5908|Hs108|chr12 ( 142) 413 92.8 1e-19 CCDS5927.1 RHEB gene_id:6009|Hs108|chr7 ( 184) 409 92.1 2.1e-19 CCDS641.1 DIRAS3 gene_id:9077|Hs108|chr1 ( 229) 366 83.5 1e-16 CCDS35246.1 ERAS gene_id:3266|Hs108|chrX ( 233) 363 82.9 1.6e-16 CCDS11703.1 RAB37 gene_id:326624|Hs108|chr17 ( 216) 360 82.2 2.3e-16 CCDS82198.1 RAB37 gene_id:326624|Hs108|chr17 ( 196) 359 82.0 2.4e-16 CCDS32722.1 RAB37 gene_id:326624|Hs108|chr17 ( 223) 359 82.0 2.7e-16 CCDS54161.1 RAB37 gene_id:326624|Hs108|chr17 ( 228) 359 82.1 2.7e-16 CCDS10460.1 RAB26 gene_id:25837|Hs108|chr16 ( 256) 359 82.1 2.9e-16 CCDS14766.1 RAB39B gene_id:116442|Hs108|chrX ( 213) 349 80.0 1e-15 CCDS13181.1 REM1 gene_id:28954|Hs108|chr20 ( 298) 349 80.1 1.3e-15 CCDS46306.1 RAB1A gene_id:5861|Hs108|chr2 ( 205) 345 79.2 1.8e-15 CCDS76806.1 RAB26 gene_id:25837|Hs108|chr16 ( 190) 344 79.0 1.9e-15 CCDS31613.1 RAB1B gene_id:81876|Hs108|chr11 ( 201) 343 78.8 2.3e-15 CCDS14156.1 RAB9A gene_id:9367|Hs108|chrX ( 201) 341 78.4 3.1e-15 CCDS10200.1 RASL12 gene_id:51285|Hs108|chr15 ( 266) 340 78.3 4.3e-15 CCDS14515.1 RAB9B gene_id:51209|Hs108|chrX ( 201) 337 77.6 5.4e-15 CCDS42410.1 RAB12 gene_id:201475|Hs108|chr18 ( 244) 337 77.6 6.2e-15 CCDS6175.1 RAB2A gene_id:5862|Hs108|chr8 ( 212) 335 77.2 7.4e-15 CCDS1058.1 RAB13 gene_id:5872|Hs108|chr1 ( 203) 332 76.6 1.1e-14 CCDS11185.1 RASD1 gene_id:51655|Hs108|chr17 ( 281) 332 76.7 1.4e-14 CCDS6261.1 GEM gene_id:2669|Hs108|chr8 ( 296) 330 76.3 1.9e-14 CCDS2520.1 RAB17 gene_id:64284|Hs108|chr2 ( 212) 328 75.8 2e-14 >>CCDS14632.1 RAP2C gene_id:57826|Hs108|chrX (183 aa) initn: 1193 init1: 1193 opt: 1193 Z-score: 1317.8 bits: 250.5 E(32554): 4.4e-67 Smith-Waterman score: 1193; 100.0% identity (100.0% similar) in 183 aa overlap (1-183:1-183) 10 20 30 40 50 60 pF1KE3 MREYKVVVLGSGGVGKSALTVQFVTGTFIEKYDPTIEDFYRKEIEVDSSPSVLEILDTAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS14 MREYKVVVLGSGGVGKSALTVQFVTGTFIEKYDPTIEDFYRKEIEVDSSPSVLEILDTAG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 TEQFASMRDLYIKNGQGFILVYSLVNQQSFQDIKPMRDQIVRVKRYEKVPLILVGNKVDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS14 TEQFASMRDLYIKNGQGFILVYSLVNQQSFQDIKPMRDQIVRVKRYEKVPLILVGNKVDL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 EPEREVMSSEGRALAQEWGCPFMETSAKSKSMVDELFAEIVRQMNYSSLPEKQDQCCTTC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS14 EPEREVMSSEGRALAQEWGCPFMETSAKSKSMVDELFAEIVRQMNYSSLPEKQDQCCTTC 130 140 150 160 170 180 pF1KE3 VVQ ::: CCDS14 VVQ >>CCDS9485.1 RAP2A gene_id:5911|Hs108|chr13 (183 aa) initn: 1126 init1: 1109 opt: 1109 Z-score: 1226.1 bits: 233.5 E(32554): 5.6e-62 Smith-Waterman score: 1109; 91.3% identity (97.3% similar) in 183 aa overlap (1-183:1-183) 10 20 30 40 50 60 pF1KE3 MREYKVVVLGSGGVGKSALTVQFVTGTFIEKYDPTIEDFYRKEIEVDSSPSVLEILDTAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS94 MREYKVVVLGSGGVGKSALTVQFVTGTFIEKYDPTIEDFYRKEIEVDSSPSVLEILDTAG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 TEQFASMRDLYIKNGQGFILVYSLVNQQSFQDIKPMRDQIVRVKRYEKVPLILVGNKVDL ::::::::::::::::::::::::::::::::::::::::.:::::::::.::::::::: CCDS94 TEQFASMRDLYIKNGQGFILVYSLVNQQSFQDIKPMRDQIIRVKRYEKVPVILVGNKVDL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 EPEREVMSSEGRALAQEWGCPFMETSAKSKSMVDELFAEIVRQMNYSSLPEKQDQCCTTC : :::: ::::::::.::::::::::::::.:::::::::::::::.. :.:.: ::..: CCDS94 ESEREVSSSEGRALAEEWGCPFMETSAKSKTMVDELFAEIVRQMNYAAQPDKDDPCCSAC 130 140 150 160 170 180 pF1KE3 VVQ .: CCDS94 NIQ >>CCDS3170.1 RAP2B gene_id:5912|Hs108|chr3 (183 aa) initn: 1067 init1: 1050 opt: 1050 Z-score: 1161.7 bits: 221.6 E(32554): 2.2e-58 Smith-Waterman score: 1050; 86.3% identity (96.2% similar) in 182 aa overlap (1-182:1-182) 10 20 30 40 50 60 pF1KE3 MREYKVVVLGSGGVGKSALTVQFVTGTFIEKYDPTIEDFYRKEIEVDSSPSVLEILDTAG ::::::::::::::::::::::::::.::::::::::::::::::::::::::::::::: CCDS31 MREYKVVVLGSGGVGKSALTVQFVTGSFIEKYDPTIEDFYRKEIEVDSSPSVLEILDTAG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 TEQFASMRDLYIKNGQGFILVYSLVNQQSFQDIKPMRDQIVRVKRYEKVPLILVGNKVDL ::::::::::::::::::::::::::::::::::::::::.::::::.::.::::::::: CCDS31 TEQFASMRDLYIKNGQGFILVYSLVNQQSFQDIKPMRDQIIRVKRYERVPMILVGNKVDL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 EPEREVMSSEGRALAQEWGCPFMETSAKSKSMVDELFAEIVRQMNYSSLPEKQDQCCTTC : :::: .::.:::.::.:::::::::.:. ::::::::::::::.. :. .. ::..: CCDS31 EGEREVSYGEGKALAEEWSCPFMETSAKNKASVDELFAEIVRQMNYAAQPNGDEGCCSAC 130 140 150 160 170 180 pF1KE3 VVQ :. CCDS31 VIL >>CCDS76024.1 RAP2C gene_id:57826|Hs108|chrX (117 aa) initn: 781 init1: 781 opt: 781 Z-score: 870.5 bits: 167.0 E(32554): 3.6e-42 Smith-Waterman score: 781; 100.0% identity (100.0% similar) in 117 aa overlap (67-183:1-117) 40 50 60 70 80 90 pF1KE3 EDFYRKEIEVDSSPSVLEILDTAGTEQFASMRDLYIKNGQGFILVYSLVNQQSFQDIKPM :::::::::::::::::::::::::::::: CCDS76 MRDLYIKNGQGFILVYSLVNQQSFQDIKPM 10 20 30 100 110 120 130 140 150 pF1KE3 RDQIVRVKRYEKVPLILVGNKVDLEPEREVMSSEGRALAQEWGCPFMETSAKSKSMVDEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS76 RDQIVRVKRYEKVPLILVGNKVDLEPEREVMSSEGRALAQEWGCPFMETSAKSKSMVDEL 40 50 60 70 80 90 160 170 180 pF1KE3 FAEIVRQMNYSSLPEKQDQCCTTCVVQ ::::::::::::::::::::::::::: CCDS76 FAEIVRQMNYSSLPEKQDQCCTTCVVQ 100 110 >>CCDS840.1 RAP1A gene_id:5906|Hs108|chr1 (184 aa) initn: 703 init1: 634 opt: 744 Z-score: 827.6 bits: 159.7 E(32554): 8.9e-40 Smith-Waterman score: 744; 61.7% identity (83.1% similar) in 183 aa overlap (1-182:1-183) 10 20 30 40 50 60 pF1KE3 MREYKVVVLGSGGVGKSALTVQFVTGTFIEKYDPTIEDFYRKEIEVDSSPSVLEILDTAG :::::.:::::::::::::::::: : :.::::::::: :::..::: . .:::::::: CCDS84 MREYKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQVEVDCQQCMLEILDTAG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 TEQFASMRDLYIKNGQGFILVYSLVNQQSFQDIKPMRDQIVRVKRYEKVPLILVGNKVDL ::::..:::::.:::::: ::::.. :..:.:.. .:.::.::: : ::.:::::: :: CCDS84 TEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTEDVPMILVGNKCDL 70 80 90 100 110 120 130 140 150 160 170 pF1KE3 EPEREVMSSEGRALAQEW-GCPFMETSAKSKSMVDELFAEIVRQMNYSSLPEKQDQCCTT : :: : . .:. ::..: .: :.:.::::: :.:.: ..:::.: .. ::. . CCDS84 EDERVVGKEQGQNLARQWCNCAFLESSAKSKINVNEIFYDLVRQINRKTPVEKKKPKKKS 130 140 150 160 170 180 180 pF1KE3 CVVQ :.. CCDS84 CLLL >>CCDS8984.1 RAP1B gene_id:5908|Hs108|chr12 (184 aa) initn: 694 init1: 632 opt: 731 Z-score: 813.4 bits: 157.1 E(32554): 5.5e-39 Smith-Waterman score: 731; 61.9% identity (85.1% similar) in 181 aa overlap (1-176:1-181) 10 20 30 40 50 60 pF1KE3 MREYKVVVLGSGGVGKSALTVQFVTGTFIEKYDPTIEDFYRKEIEVDSSPSVLEILDTAG :::::.:::::::::::::::::: : :.::::::::: :::..:::.. .:::::::: CCDS89 MREYKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQVEVDAQQCMLEILDTAG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 TEQFASMRDLYIKNGQGFILVYSLVNQQSFQDIKPMRDQIVRVKRYEKVPLILVGNKVDL ::::..:::::.:::::: ::::.. :..:.:.. .:.::.::: . ::.:::::: :: CCDS89 TEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTDDVPMILVGNKCDL 70 80 90 100 110 120 130 140 150 160 170 pF1KE3 EPEREVMSSEGRALAQEWG-CPFMETSAKSKSMVDELFAEIVRQMNYSS-LP---EKQDQ : :: : . .:. ::..:. : :.:.::::: :.:.: ..:::.: .. .: .:... CCDS89 EDERVVGKEQGQNLARQWNNCAFLESSAKSKINVNEIFYDLVRQINRKTPVPGKARKKSS 130 140 150 160 170 180 180 pF1KE3 CCTTCVVQ : CCDS89 CQLL >>CCDS8702.1 KRAS gene_id:3845|Hs108|chr12 (188 aa) initn: 560 init1: 471 opt: 583 Z-score: 651.7 bits: 127.2 E(32554): 5.6e-30 Smith-Waterman score: 583; 46.8% identity (76.1% similar) in 188 aa overlap (1-182:1-187) 10 20 30 40 50 60 pF1KE3 MREYKVVVLGSGGVGKSALTVQFVTGTFIEKYDPTIEDFYRKEIEVDSSPSVLEILDTAG : :::.::.:.:::::::::.:.. . :...::::::: :::.. .:. .:.:::::: CCDS87 MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 TEQFASMRDLYIKNGQGFILVYSLVNQQSFQDIKPMRDQIVRVKRYEKVPLILVGNKVDL :....::: :...:.::. :... : .::.::. .:.:: ::: : ::..::::: :: CCDS87 QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDL 70 80 90 100 110 120 130 140 150 160 170 pF1KE3 EPEREVMSSEGRALAQEWGCPFMETSAKSKSMVDELFAEIVRQMNYSSLPEKQD------ : : : ..... ::. .: ::.:::::... ::. : .::.. . ..: CCDS87 -PSRTVDTKQAQDLARSYGIPFIETSAKTRQGVDDAFYTLVREIRKHKEKMSKDGKKKKK 130 140 150 160 170 180 pF1KE3 QCCTTCVVQ . : ::. CCDS87 KSKTKCVIM 180 >>CCDS8703.1 KRAS gene_id:3845|Hs108|chr12 (189 aa) initn: 555 init1: 471 opt: 581 Z-score: 649.5 bits: 126.8 E(32554): 7.4e-30 Smith-Waterman score: 581; 47.3% identity (78.0% similar) in 182 aa overlap (1-181:1-181) 10 20 30 40 50 60 pF1KE3 MREYKVVVLGSGGVGKSALTVQFVTGTFIEKYDPTIEDFYRKEIEVDSSPSVLEILDTAG : :::.::.:.:::::::::.:.. . :...::::::: :::.. .:. .:.:::::: CCDS87 MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 TEQFASMRDLYIKNGQGFILVYSLVNQQSFQDIKPMRDQIVRVKRYEKVPLILVGNKVDL :....::: :...:.::. :... : .::.::. .:.:: ::: : ::..::::: :: CCDS87 QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDL 70 80 90 100 110 120 130 140 150 160 170 pF1KE3 EPEREVMSSEGRALAQEWGCPFMETSAKSKSMVDELFAEIVRQMNYSSLPE-KQDQCCTT : : : ..... ::. .: ::.:::::... :.. : .::.. : . .... CCDS87 -PSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPG 130 140 150 160 170 180 pF1KE3 CVVQ :: CCDS87 CVKIKKCIIM 180 >>CCDS7698.1 HRAS gene_id:3265|Hs108|chr11 (189 aa) initn: 549 init1: 468 opt: 578 Z-score: 646.2 bits: 126.2 E(32554): 1.1e-29 Smith-Waterman score: 578; 45.9% identity (76.2% similar) in 185 aa overlap (1-180:1-184) 10 20 30 40 50 60 pF1KE3 MREYKVVVLGSGGVGKSALTVQFVTGTFIEKYDPTIEDFYRKEIEVDSSPSVLEILDTAG : :::.::.:.:::::::::.:.. . :...::::::: :::.. .:. .:.:::::: CCDS76 MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 TEQFASMRDLYIKNGQGFILVYSLVNQQSFQDIKPMRDQIVRVKRYEKVPLILVGNKVDL :....::: :...:.::. :... : .::.::. .:.:: ::: . ::..::::: :: CCDS76 QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHQYREQIKRVKDSDDVPMVLVGNKCDL 70 80 90 100 110 120 130 140 150 160 170 pF1KE3 EPEREVMSSEGRALAQEWGCPFMETSAKSKSMVDELFAEIVRQMNYSSL-----PEKQDQ : : : ... ::. .: :..:::::... :.. : .::.. .: :... CCDS76 AA-RTVESRQAQDLARSYGIPYIETSAKTRQGVEDAFYTLVREIRQHKLRKLNPPDESGP 130 140 150 160 170 180 pF1KE3 CCTTCVVQ : .: CCDS76 GCMSCKCVLS 180 >>CCDS877.1 NRAS gene_id:4893|Hs108|chr1 (189 aa) initn: 547 init1: 463 opt: 574 Z-score: 641.8 bits: 125.4 E(32554): 2e-29 Smith-Waterman score: 574; 47.6% identity (77.2% similar) in 189 aa overlap (1-182:1-188) 10 20 30 40 50 60 pF1KE3 MREYKVVVLGSGGVGKSALTVQFVTGTFIEKYDPTIEDFYRKEIEVDSSPSVLEILDTAG : :::.::.:.:::::::::.:.. . :...::::::: :::.. .:. .:.:::::: CCDS87 MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 TEQFASMRDLYIKNGQGFILVYSLVNQQSFQDIKPMRDQIVRVKRYEKVPLILVGNKVDL :....::: :...:.::. :... :..:: ::. .:.:: ::: . ::..::::: :: CCDS87 QEEYSAMRDQYMRTGEGFLCVFAINNSKSFADINLYREQIKRVKDSDDVPMVLVGNKCDL 70 80 90 100 110 120 130 140 150 160 170 pF1KE3 EPEREVMSSEGRALAQEWGCPFMETSAKSKSMVDELFAEIVR---QMNYSSLPEKQD--Q : : : ..... ::. .: ::.:::::... :.. : .:: :. ...: ..: : CCDS87 -PTRTVDTKQAHELAKSYGIPFIETSAKTRQGVEDAFYTLVREIRQYRMKKLNSSDDGTQ 130 140 150 160 170 180 pF1KE3 CCT--TCVVQ : ::: CCDS87 GCMGLPCVVM 180 183 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 02:20:04 2016 done: Sun Nov 6 02:20:04 2016 Total Scan time: 1.730 Total Display time: -0.010 Function used was FASTA [36.3.4 Apr, 2011]