FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE4136, 547 aa 1>>>pF1KE4136 547 - 547 aa - 547 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.3149+/-0.000371; mu= 14.2688+/- 0.023 mean_var=93.4801+/-19.618, 0's: 0 Z-trim(115.0): 304 B-trim: 608 in 1/55 Lambda= 0.132652 statistics sampled from 24787 (25107) to 24787 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.666), E-opt: 0.2 (0.294), width: 16 Scan time: 10.880 The best scores are: opt bits E(85289) NP_659404 (OMIM: 300937) rho GTPase-activating pro ( 547) 3583 696.1 7e-200 NP_001269536 (OMIM: 300937) rho GTPase-activating ( 535) 3368 655.0 1.7e-187 NP_001317580 (OMIM: 300937) rho GTPase-activating ( 411) 2684 524.0 3.4e-148 XP_011529582 (OMIM: 300937) PREDICTED: rho GTPase- ( 411) 2684 524.0 3.4e-148 NP_006116 (OMIM: 300118) rho GTPase-activating pro ( 765) 908 184.3 1.2e-45 NP_038267 (OMIM: 300118) rho GTPase-activating pro ( 771) 908 184.3 1.2e-45 NP_001274171 (OMIM: 300118) rho GTPase-activating ( 794) 908 184.3 1.2e-45 NP_038286 (OMIM: 300118) rho GTPase-activating pro ( 974) 908 184.3 1.5e-45 XP_011531508 (OMIM: 610587) PREDICTED: rho GTPase- ( 620) 296 67.1 1.8e-10 XP_011531510 (OMIM: 610587) PREDICTED: rho GTPase- ( 620) 296 67.1 1.8e-10 XP_011531509 (OMIM: 610587) PREDICTED: rho GTPase- ( 620) 296 67.1 1.8e-10 NP_001159748 (OMIM: 610587) rho GTPase-activating ( 639) 296 67.1 1.9e-10 NP_001007232 (OMIM: 610587) rho GTPase-activating ( 646) 296 67.1 1.9e-10 XP_016860912 (OMIM: 610587) PREDICTED: rho GTPase- ( 650) 296 67.1 1.9e-10 NP_055697 (OMIM: 610587) rho GTPase-activating pro ( 638) 289 65.8 4.7e-10 XP_005264732 (OMIM: 610587) PREDICTED: rho GTPase- ( 645) 289 65.8 4.7e-10 XP_016860913 (OMIM: 610587) PREDICTED: rho GTPase- ( 649) 289 65.8 4.8e-10 NP_001159749 (OMIM: 610587) rho GTPase-activating ( 606) 283 64.6 1e-09 XP_011531511 (OMIM: 610587) PREDICTED: rho GTPase- ( 528) 281 64.2 1.2e-09 XP_005264733 (OMIM: 610587) PREDICTED: rho GTPase- ( 607) 281 64.2 1.3e-09 XP_016860914 (OMIM: 610587) PREDICTED: rho GTPase- ( 611) 281 64.2 1.3e-09 XP_011517909 (OMIM: 609870) PREDICTED: rho GTPase- (1491) 284 65.0 1.9e-09 XP_011517908 (OMIM: 609870) PREDICTED: rho GTPase- (1924) 284 65.1 2.3e-09 XP_005252601 (OMIM: 609870) PREDICTED: rho GTPase- (1948) 284 65.1 2.3e-09 XP_016871949 (OMIM: 609870) PREDICTED: rho GTPase- (1948) 284 65.1 2.3e-09 XP_016871950 (OMIM: 609870) PREDICTED: rho GTPase- (1948) 284 65.1 2.3e-09 XP_005252599 (OMIM: 609870) PREDICTED: rho GTPase- (1958) 284 65.1 2.3e-09 XP_016871948 (OMIM: 609870) PREDICTED: rho GTPase- (1958) 284 65.1 2.3e-09 NP_065875 (OMIM: 609870) rho GTPase-activating pro (1958) 284 65.1 2.3e-09 XP_011517907 (OMIM: 609870) PREDICTED: rho GTPase- (1982) 284 65.1 2.4e-09 XP_011517906 (OMIM: 609870) PREDICTED: rho GTPase- (1992) 284 65.1 2.4e-09 XP_011517905 (OMIM: 609870) PREDICTED: rho GTPase- (1992) 284 65.1 2.4e-09 XP_011517904 (OMIM: 609870) PREDICTED: rho GTPase- (1992) 284 65.1 2.4e-09 NP_001157743 (OMIM: 114500,604258) rho GTPase-acti (1017) 278 63.8 3e-09 XP_016868441 (OMIM: 114500,604258) PREDICTED: rho (1017) 278 63.8 3e-09 NP_006085 (OMIM: 114500,604258) rho GTPase-activat (1091) 278 63.8 3.2e-09 NP_001303597 (OMIM: 114500,604258) rho GTPase-acti (1125) 278 63.8 3.2e-09 XP_005273431 (OMIM: 114500,604258) PREDICTED: rho (1528) 278 63.9 4.2e-09 NP_872584 (OMIM: 114500,604258) rho GTPase-activat (1528) 278 63.9 4.2e-09 XP_016868440 (OMIM: 114500,604258) PREDICTED: rho (1528) 278 63.9 4.2e-09 NP_055540 (OMIM: 300689) stAR-related lipid transf (1023) 267 61.7 1.3e-08 XP_011529371 (OMIM: 300689) PREDICTED: stAR-relate (1023) 267 61.7 1.3e-08 NP_001135976 (OMIM: 300689) stAR-related lipid tra (1023) 267 61.7 1.3e-08 XP_011529372 (OMIM: 300689) PREDICTED: stAR-relate (1027) 267 61.7 1.3e-08 XP_005262372 (OMIM: 300689) PREDICTED: stAR-relate (1027) 267 61.7 1.3e-08 NP_001135975 (OMIM: 300689) stAR-related lipid tra (1103) 267 61.7 1.4e-08 XP_005262371 (OMIM: 300689) PREDICTED: stAR-relate (1107) 267 61.7 1.4e-08 NP_001243776 (OMIM: 600365) active breakpoint clus ( 310) 251 58.3 4e-08 XP_011509785 (OMIM: 610578) PREDICTED: rho GTPase- ( 397) 247 57.6 8.3e-08 XP_016859989 (OMIM: 610578) PREDICTED: rho GTPase- ( 432) 247 57.7 8.9e-08 >>NP_659404 (OMIM: 300937) rho GTPase-activating protein (547 aa) initn: 3583 init1: 3583 opt: 3583 Z-score: 3709.4 bits: 696.1 E(85289): 7e-200 Smith-Waterman score: 3583; 100.0% identity (100.0% similar) in 547 aa overlap (1-547:1-547) 10 20 30 40 50 60 pF1KE4 MGGCIPFLKAARALCPRIMPPLLLLSAFIFLVSVLGGAPGHNPDRRTKMVSIHSLSELER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_659 MGGCIPFLKAARALCPRIMPPLLLLSAFIFLVSVLGGAPGHNPDRRTKMVSIHSLSELER 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 LKLQETAYHELVARHFLSEFKPDRALPIDRPNTLDKWFLILRGQQRAVSHKTFGISLEEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_659 LKLQETAYHELVARHFLSEFKPDRALPIDRPNTLDKWFLILRGQQRAVSHKTFGISLEEV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 LVNEFTRRKHLELTATMQVEEATGQAAGRRRGNVVRRVFGRIRRFFSRRRNEPTLPREFT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_659 LVNEFTRRKHLELTATMQVEEATGQAAGRRRGNVVRRVFGRIRRFFSRRRNEPTLPREFT 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 RRGRRGAVSVDSLAELEDGALLLQTLQLSKISFPIGQRLLGSKRKMSLNPIAKQIPQVVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_659 RRGRRGAVSVDSLAELEDGALLLQTLQLSKISFPIGQRLLGSKRKMSLNPIAKQIPQVVE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 ACCQFIEKHGLSAVGIFTLEYSVQRVRQLREEFDQGLDVVLDDNQNVHDVAALLKEFFRD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_659 ACCQFIEKHGLSAVGIFTLEYSVQRVRQLREEFDQGLDVVLDDNQNVHDVAALLKEFFRD 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 MKDSLLPDDLYMSFLLTATLKPQDQLSALQLLVYLMPPCHSDTLERLLKALHKITENCED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_659 MKDSLLPDDLYMSFLLTATLKPQDQLSALQLLVYLMPPCHSDTLERLLKALHKITENCED 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 SIGIDGQLVPGNRMTSTNLALVFGSALLKKGKFGKRESRKTKLGIDHYVASVNVVRAMID :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_659 SIGIDGQLVPGNRMTSTNLALVFGSALLKKGKFGKRESRKTKLGIDHYVASVNVVRAMID 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE4 NWDVLFQVPPHIQRQVAKRVWKSSPEALDFIRRRNLRKIQSARIKMEEDALLSDPVETSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_659 NWDVLFQVPPHIQRQVAKRVWKSSPEALDFIRRRNLRKIQSARIKMEEDALLSDPVETSA 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE4 EARAAVLAQSKPSDEGSSEEPAVPSGTARSHDDEEGAGNPPIPEQDRPLLRVPREKEAKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_659 EARAAVLAQSKPSDEGSSEEPAVPSGTARSHDDEEGAGNPPIPEQDRPLLRVPREKEAKT 490 500 510 520 530 540 pF1KE4 GVSYFFP ::::::: NP_659 GVSYFFP >>NP_001269536 (OMIM: 300937) rho GTPase-activating prot (535 aa) initn: 3368 init1: 3368 opt: 3368 Z-score: 3487.2 bits: 655.0 E(85289): 1.7e-187 Smith-Waterman score: 3368; 100.0% identity (100.0% similar) in 516 aa overlap (32-547:20-535) 10 20 30 40 50 60 pF1KE4 GGCIPFLKAARALCPRIMPPLLLLSAFIFLVSVLGGAPGHNPDRRTKMVSIHSLSELERL :::::::::::::::::::::::::::::: NP_001 MAWILDCLFASAFEPRPRRVSVLGGAPGHNPDRRTKMVSIHSLSELERL 10 20 30 40 70 80 90 100 110 120 pF1KE4 KLQETAYHELVARHFLSEFKPDRALPIDRPNTLDKWFLILRGQQRAVSHKTFGISLEEVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KLQETAYHELVARHFLSEFKPDRALPIDRPNTLDKWFLILRGQQRAVSHKTFGISLEEVL 50 60 70 80 90 100 130 140 150 160 170 180 pF1KE4 VNEFTRRKHLELTATMQVEEATGQAAGRRRGNVVRRVFGRIRRFFSRRRNEPTLPREFTR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VNEFTRRKHLELTATMQVEEATGQAAGRRRGNVVRRVFGRIRRFFSRRRNEPTLPREFTR 110 120 130 140 150 160 190 200 210 220 230 240 pF1KE4 RGRRGAVSVDSLAELEDGALLLQTLQLSKISFPIGQRLLGSKRKMSLNPIAKQIPQVVEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RGRRGAVSVDSLAELEDGALLLQTLQLSKISFPIGQRLLGSKRKMSLNPIAKQIPQVVEA 170 180 190 200 210 220 250 260 270 280 290 300 pF1KE4 CCQFIEKHGLSAVGIFTLEYSVQRVRQLREEFDQGLDVVLDDNQNVHDVAALLKEFFRDM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CCQFIEKHGLSAVGIFTLEYSVQRVRQLREEFDQGLDVVLDDNQNVHDVAALLKEFFRDM 230 240 250 260 270 280 310 320 330 340 350 360 pF1KE4 KDSLLPDDLYMSFLLTATLKPQDQLSALQLLVYLMPPCHSDTLERLLKALHKITENCEDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KDSLLPDDLYMSFLLTATLKPQDQLSALQLLVYLMPPCHSDTLERLLKALHKITENCEDS 290 300 310 320 330 340 370 380 390 400 410 420 pF1KE4 IGIDGQLVPGNRMTSTNLALVFGSALLKKGKFGKRESRKTKLGIDHYVASVNVVRAMIDN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IGIDGQLVPGNRMTSTNLALVFGSALLKKGKFGKRESRKTKLGIDHYVASVNVVRAMIDN 350 360 370 380 390 400 430 440 450 460 470 480 pF1KE4 WDVLFQVPPHIQRQVAKRVWKSSPEALDFIRRRNLRKIQSARIKMEEDALLSDPVETSAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 WDVLFQVPPHIQRQVAKRVWKSSPEALDFIRRRNLRKIQSARIKMEEDALLSDPVETSAE 410 420 430 440 450 460 490 500 510 520 530 540 pF1KE4 ARAAVLAQSKPSDEGSSEEPAVPSGTARSHDDEEGAGNPPIPEQDRPLLRVPREKEAKTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ARAAVLAQSKPSDEGSSEEPAVPSGTARSHDDEEGAGNPPIPEQDRPLLRVPREKEAKTG 470 480 490 500 510 520 pF1KE4 VSYFFP :::::: NP_001 VSYFFP 530 >>NP_001317580 (OMIM: 300937) rho GTPase-activating prot (411 aa) initn: 2684 init1: 2684 opt: 2684 Z-score: 2781.5 bits: 524.0 E(85289): 3.4e-148 Smith-Waterman score: 2684; 100.0% identity (100.0% similar) in 411 aa overlap (137-547:1-411) 110 120 130 140 150 160 pF1KE4 AVSHKTFGISLEEVLVNEFTRRKHLELTATMQVEEATGQAAGRRRGNVVRRVFGRIRRFF :::::::::::::::::::::::::::::: NP_001 MQVEEATGQAAGRRRGNVVRRVFGRIRRFF 10 20 30 170 180 190 200 210 220 pF1KE4 SRRRNEPTLPREFTRRGRRGAVSVDSLAELEDGALLLQTLQLSKISFPIGQRLLGSKRKM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SRRRNEPTLPREFTRRGRRGAVSVDSLAELEDGALLLQTLQLSKISFPIGQRLLGSKRKM 40 50 60 70 80 90 230 240 250 260 270 280 pF1KE4 SLNPIAKQIPQVVEACCQFIEKHGLSAVGIFTLEYSVQRVRQLREEFDQGLDVVLDDNQN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SLNPIAKQIPQVVEACCQFIEKHGLSAVGIFTLEYSVQRVRQLREEFDQGLDVVLDDNQN 100 110 120 130 140 150 290 300 310 320 330 340 pF1KE4 VHDVAALLKEFFRDMKDSLLPDDLYMSFLLTATLKPQDQLSALQLLVYLMPPCHSDTLER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VHDVAALLKEFFRDMKDSLLPDDLYMSFLLTATLKPQDQLSALQLLVYLMPPCHSDTLER 160 170 180 190 200 210 350 360 370 380 390 400 pF1KE4 LLKALHKITENCEDSIGIDGQLVPGNRMTSTNLALVFGSALLKKGKFGKRESRKTKLGID :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LLKALHKITENCEDSIGIDGQLVPGNRMTSTNLALVFGSALLKKGKFGKRESRKTKLGID 220 230 240 250 260 270 410 420 430 440 450 460 pF1KE4 HYVASVNVVRAMIDNWDVLFQVPPHIQRQVAKRVWKSSPEALDFIRRRNLRKIQSARIKM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HYVASVNVVRAMIDNWDVLFQVPPHIQRQVAKRVWKSSPEALDFIRRRNLRKIQSARIKM 280 290 300 310 320 330 470 480 490 500 510 520 pF1KE4 EEDALLSDPVETSAEARAAVLAQSKPSDEGSSEEPAVPSGTARSHDDEEGAGNPPIPEQD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EEDALLSDPVETSAEARAAVLAQSKPSDEGSSEEPAVPSGTARSHDDEEGAGNPPIPEQD 340 350 360 370 380 390 530 540 pF1KE4 RPLLRVPREKEAKTGVSYFFP ::::::::::::::::::::: NP_001 RPLLRVPREKEAKTGVSYFFP 400 410 >>XP_011529582 (OMIM: 300937) PREDICTED: rho GTPase-acti (411 aa) initn: 2684 init1: 2684 opt: 2684 Z-score: 2781.5 bits: 524.0 E(85289): 3.4e-148 Smith-Waterman score: 2684; 100.0% identity (100.0% similar) in 411 aa overlap (137-547:1-411) 110 120 130 140 150 160 pF1KE4 AVSHKTFGISLEEVLVNEFTRRKHLELTATMQVEEATGQAAGRRRGNVVRRVFGRIRRFF :::::::::::::::::::::::::::::: XP_011 MQVEEATGQAAGRRRGNVVRRVFGRIRRFF 10 20 30 170 180 190 200 210 220 pF1KE4 SRRRNEPTLPREFTRRGRRGAVSVDSLAELEDGALLLQTLQLSKISFPIGQRLLGSKRKM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SRRRNEPTLPREFTRRGRRGAVSVDSLAELEDGALLLQTLQLSKISFPIGQRLLGSKRKM 40 50 60 70 80 90 230 240 250 260 270 280 pF1KE4 SLNPIAKQIPQVVEACCQFIEKHGLSAVGIFTLEYSVQRVRQLREEFDQGLDVVLDDNQN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SLNPIAKQIPQVVEACCQFIEKHGLSAVGIFTLEYSVQRVRQLREEFDQGLDVVLDDNQN 100 110 120 130 140 150 290 300 310 320 330 340 pF1KE4 VHDVAALLKEFFRDMKDSLLPDDLYMSFLLTATLKPQDQLSALQLLVYLMPPCHSDTLER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VHDVAALLKEFFRDMKDSLLPDDLYMSFLLTATLKPQDQLSALQLLVYLMPPCHSDTLER 160 170 180 190 200 210 350 360 370 380 390 400 pF1KE4 LLKALHKITENCEDSIGIDGQLVPGNRMTSTNLALVFGSALLKKGKFGKRESRKTKLGID :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LLKALHKITENCEDSIGIDGQLVPGNRMTSTNLALVFGSALLKKGKFGKRESRKTKLGID 220 230 240 250 260 270 410 420 430 440 450 460 pF1KE4 HYVASVNVVRAMIDNWDVLFQVPPHIQRQVAKRVWKSSPEALDFIRRRNLRKIQSARIKM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HYVASVNVVRAMIDNWDVLFQVPPHIQRQVAKRVWKSSPEALDFIRRRNLRKIQSARIKM 280 290 300 310 320 330 470 480 490 500 510 520 pF1KE4 EEDALLSDPVETSAEARAAVLAQSKPSDEGSSEEPAVPSGTARSHDDEEGAGNPPIPEQD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EEDALLSDPVETSAEARAAVLAQSKPSDEGSSEEPAVPSGTARSHDDEEGAGNPPIPEQD 340 350 360 370 380 390 530 540 pF1KE4 RPLLRVPREKEAKTGVSYFFP ::::::::::::::::::::: XP_011 RPLLRVPREKEAKTGVSYFFP 400 410 >>NP_006116 (OMIM: 300118) rho GTPase-activating protein (765 aa) initn: 934 init1: 691 opt: 908 Z-score: 940.5 bits: 184.3 E(85289): 1.2e-45 Smith-Waterman score: 974; 37.8% identity (66.9% similar) in 489 aa overlap (46-509:210-695) 20 30 40 50 60 70 pF1KE4 PRIMPPLLLLSAFIFLVSVLGGAPGHNPDRRTKMVSIHSLSELERLKLQETAYHELVARH : . : :.::::::: .:::.:...: NP_006 QSPPDSRGHPYVVWKSEGDFTWNSMSGRSVRLRSVPIQSLSELERARLQEVAFYQLQQDC 180 190 200 210 220 230 80 90 100 110 120 pF1KE4 FLSEFKPDRALPID---RPNTLDKWFLIL---RGQQRAVSHKTFGISLEEVLVNEFTRRK :: . ..: : : ..: : . : ..... ..::. : .:..:. . . NP_006 DLSC---QITIPKDGQKRKKSLRKKLDSLGKEKNKDKEFIPQAFGMPLSQVIANDRAYKL 240 250 260 270 280 290 130 140 150 160 170 180 pF1KE4 HLELTATMQVEEATGQAA----GRRRGNVVRRVFGRIRRFFSRRRNE---PTLPREFTRR . .: : . . :. : .: : . :. :: :. :. : NP_006 KQDLQRDEQKDASDFVASLLPFGNKRQNKELSSSNSSLSSTSETPNESTSPNTPEPAPRA 300 310 320 330 340 350 190 200 210 220 230 240 pF1KE4 GRRGAVSVDSLAELEDG-ALLLQTLQLSKISFPIGQRLLGSKRKMSLNPIAKQIPQVVEA ::::.::::...:.:. . ::..:::: . ... . .:.::::: .:.:..:.. NP_006 RRRGAMSVDSITDLDDNQSRLLEALQLSLPAEAQSKKEKARDKKLSLNPIYRQVPRLVDS 360 370 380 390 400 410 250 260 270 280 290 300 pF1KE4 CCQFIEKHGLSAVGIFTLEYSVQRVRQLREEFDQGLDVVLDDNQNVHDVAALLKEFFRDM ::: .:::::..:::: . : .::::::::::.:.:: :.....:::::::::::.::: NP_006 CCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVSLEEEHSVHDVAALLKEFLRDM 420 430 440 450 460 470 310 320 330 340 350 360 pF1KE4 KDSLLPDDLYMSFLLTATLKPQDQLSALQLLVYLMPPCHSDTLERLLKALHKITENCEDS : :: .:: .:. : :.:..::..::::.::.:::. :::.:::. : .... .:. NP_006 PDPLLTRELYTAFINTLLLEPEEQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVARHADDN 480 490 500 510 520 530 370 380 390 400 410 420 pF1KE4 IGIDGQLVPGNRMTSTNLALVFGSALLKKGKFGKRE-SRKTKLGIDHYVASVNVVRAMID :. ::: : ::.::: ::: .:: ::.: : . .: : ... .. .: . ::. ::. NP_006 ISKDGQEVTGNKMTSLNLATIFGPNLLHKQKSSDKEFSVQSSARAEESTAIIAVVQKMIE 540 550 560 570 580 590 430 440 450 460 470 480 pF1KE4 NWDVLFQVPPHIQRQVAKRVWKSSPEALDFIRRRNLRKIQSARIKMEEDALLSDPVETSA :...::.::: .: .: . ...:...:.. ::. . .: . . : .. ..:. NP_006 NYEALFMVPPDLQNEVLISLLETDPDVVDYLLRRKASQSSSPDMLQSEVSFSVGGRHSST 600 610 620 630 640 650 490 500 510 520 530 pF1KE4 EARAAVLAQSKPSDEGS---SE-------EPAVPSGTARSHDDEEGAGNPPIPEQDRPLL .. : .. .: :..: :: : :.:.:. . NP_006 DSNKASSGDISPYDNNSPVLSERSLLAMQEDAAPGGSEKLYRVPGQFMLVGHLSSSKSRE 660 670 680 690 700 710 540 pF1KE4 RVPREKEAKTGVSYFFP NP_006 SSPGPRLGKGNWSLASRRWPKQATLLLLHVAWCGALRTFSSSLPYLMFL 720 730 740 750 760 >>NP_038267 (OMIM: 300118) rho GTPase-activating protein (771 aa) initn: 934 init1: 691 opt: 908 Z-score: 940.5 bits: 184.3 E(85289): 1.2e-45 Smith-Waterman score: 974; 37.8% identity (66.9% similar) in 489 aa overlap (46-509:7-492) 20 30 40 50 60 70 pF1KE4 PRIMPPLLLLSAFIFLVSVLGGAPGHNPDRRTKMVSIHSLSELERLKLQETAYHELVARH : . : :.::::::: .:::.:...: NP_038 MSGRSVRLRSVPIQSLSELERARLQEVAFYQLQQDC 10 20 30 80 90 100 110 120 pF1KE4 FLSEFKPDRALPID---RPNTLDKWFLIL---RGQQRAVSHKTFGISLEEVLVNEFTRRK :: . ..: : : ..: : . : ..... ..::. : .:..:. . . NP_038 DLSC---QITIPKDGQKRKKSLRKKLDSLGKEKNKDKEFIPQAFGMPLSQVIANDRAYKL 40 50 60 70 80 90 130 140 150 160 170 180 pF1KE4 HLELTATMQVEEATGQAA----GRRRGNVVRRVFGRIRRFFSRRRNE---PTLPREFTRR . .: : . . :. : .: : . :. :: :. :. : NP_038 KQDLQRDEQKDASDFVASLLPFGNKRQNKELSSSNSSLSSTSETPNESTSPNTPEPAPRA 100 110 120 130 140 150 190 200 210 220 230 240 pF1KE4 GRRGAVSVDSLAELEDG-ALLLQTLQLSKISFPIGQRLLGSKRKMSLNPIAKQIPQVVEA ::::.::::...:.:. . ::..:::: . ... . .:.::::: .:.:..:.. NP_038 RRRGAMSVDSITDLDDNQSRLLEALQLSLPAEAQSKKEKARDKKLSLNPIYRQVPRLVDS 160 170 180 190 200 210 250 260 270 280 290 300 pF1KE4 CCQFIEKHGLSAVGIFTLEYSVQRVRQLREEFDQGLDVVLDDNQNVHDVAALLKEFFRDM ::: .:::::..:::: . : .::::::::::.:.:: :.....:::::::::::.::: NP_038 CCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVSLEEEHSVHDVAALLKEFLRDM 220 230 240 250 260 270 310 320 330 340 350 360 pF1KE4 KDSLLPDDLYMSFLLTATLKPQDQLSALQLLVYLMPPCHSDTLERLLKALHKITENCEDS : :: .:: .:. : :.:..::..::::.::.:::. :::.:::. : .... .:. NP_038 PDPLLTRELYTAFINTLLLEPEEQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVARHADDN 280 290 300 310 320 330 370 380 390 400 410 420 pF1KE4 IGIDGQLVPGNRMTSTNLALVFGSALLKKGKFGKRE-SRKTKLGIDHYVASVNVVRAMID :. ::: : ::.::: ::: .:: ::.: : . .: : ... .. .: . ::. ::. NP_038 ISKDGQEVTGNKMTSLNLATIFGPNLLHKQKSSDKEFSVQSSARAEESTAIIAVVQKMIE 340 350 360 370 380 390 430 440 450 460 470 480 pF1KE4 NWDVLFQVPPHIQRQVAKRVWKSSPEALDFIRRRNLRKIQSARIKMEEDALLSDPVETSA :...::.::: .: .: . ...:...:.. ::. . .: . . : .. ..:. NP_038 NYEALFMVPPDLQNEVLISLLETDPDVVDYLLRRKASQSSSPDMLQSEVSFSVGGRHSST 400 410 420 430 440 450 490 500 510 520 530 pF1KE4 EARAAVLAQSKPSDEGS---SE-------EPAVPSGTARSHDDEEGAGNPPIPEQDRPLL .. : .. .: :..: :: : :.:.:. . NP_038 DSNKASSGDISPYDNNSPVLSERSLLAMQEDAAPGGSEKLYRVPGQFMLVGHLSSSKSRE 460 470 480 490 500 510 540 pF1KE4 RVPREKEAKTGVSYFFP NP_038 SSPGPRLGKDLSEEPFDIWGTWHSTLKSGSKDPGMTGSSGDIFESSSLRAGPCSLSQGNL 520 530 540 550 560 570 >>NP_001274171 (OMIM: 300118) rho GTPase-activating prot (794 aa) initn: 934 init1: 691 opt: 908 Z-score: 940.3 bits: 184.3 E(85289): 1.2e-45 Smith-Waterman score: 974; 37.8% identity (66.9% similar) in 489 aa overlap (46-509:30-515) 20 30 40 50 60 70 pF1KE4 PRIMPPLLLLSAFIFLVSVLGGAPGHNPDRRTKMVSIHSLSELERLKLQETAYHELVARH : . : :.::::::: .:::.:...: NP_001 MGHPVYRGEKPQLHYAGDFTWNSMSGRSVRLRSVPIQSLSELERARLQEVAFYQLQQDC 10 20 30 40 50 80 90 100 110 120 pF1KE4 FLSEFKPDRALPID---RPNTLDKWFLIL---RGQQRAVSHKTFGISLEEVLVNEFTRRK :: . ..: : : ..: : . : ..... ..::. : .:..:. . . NP_001 DLSC---QITIPKDGQKRKKSLRKKLDSLGKEKNKDKEFIPQAFGMPLSQVIANDRAYKL 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE4 HLELTATMQVEEATGQAA----GRRRGNVVRRVFGRIRRFFSRRRNE---PTLPREFTRR . .: : . . :. : .: : . :. :: :. :. : NP_001 KQDLQRDEQKDASDFVASLLPFGNKRQNKELSSSNSSLSSTSETPNESTSPNTPEPAPRA 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE4 GRRGAVSVDSLAELEDG-ALLLQTLQLSKISFPIGQRLLGSKRKMSLNPIAKQIPQVVEA ::::.::::...:.:. . ::..:::: . ... . .:.::::: .:.:..:.. NP_001 RRRGAMSVDSITDLDDNQSRLLEALQLSLPAEAQSKKEKARDKKLSLNPIYRQVPRLVDS 180 190 200 210 220 230 250 260 270 280 290 300 pF1KE4 CCQFIEKHGLSAVGIFTLEYSVQRVRQLREEFDQGLDVVLDDNQNVHDVAALLKEFFRDM ::: .:::::..:::: . : .::::::::::.:.:: :.....:::::::::::.::: NP_001 CCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVSLEEEHSVHDVAALLKEFLRDM 240 250 260 270 280 290 310 320 330 340 350 360 pF1KE4 KDSLLPDDLYMSFLLTATLKPQDQLSALQLLVYLMPPCHSDTLERLLKALHKITENCEDS : :: .:: .:. : :.:..::..::::.::.:::. :::.:::. : .... .:. NP_001 PDPLLTRELYTAFINTLLLEPEEQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVARHADDN 300 310 320 330 340 350 370 380 390 400 410 420 pF1KE4 IGIDGQLVPGNRMTSTNLALVFGSALLKKGKFGKRE-SRKTKLGIDHYVASVNVVRAMID :. ::: : ::.::: ::: .:: ::.: : . .: : ... .. .: . ::. ::. NP_001 ISKDGQEVTGNKMTSLNLATIFGPNLLHKQKSSDKEFSVQSSARAEESTAIIAVVQKMIE 360 370 380 390 400 410 430 440 450 460 470 480 pF1KE4 NWDVLFQVPPHIQRQVAKRVWKSSPEALDFIRRRNLRKIQSARIKMEEDALLSDPVETSA :...::.::: .: .: . ...:...:.. ::. . .: . . : .. ..:. NP_001 NYEALFMVPPDLQNEVLISLLETDPDVVDYLLRRKASQSSSPDMLQSEVSFSVGGRHSST 420 430 440 450 460 470 490 500 510 520 530 pF1KE4 EARAAVLAQSKPSDEGS---SE-------EPAVPSGTARSHDDEEGAGNPPIPEQDRPLL .. : .. .: :..: :: : :.:.:. . NP_001 DSNKASSGDISPYDNNSPVLSERSLLAMQEDAAPGGSEKLYRVPGQFMLVGHLSSSKSRE 480 490 500 510 520 530 540 pF1KE4 RVPREKEAKTGVSYFFP NP_001 SSPGPRLGKDLSEEPFDIWGTWHSTLKSGSKDPGMTGSSGDIFESSSLRAGPCSLSQGNL 540 550 560 570 580 590 >>NP_038286 (OMIM: 300118) rho GTPase-activating protein (974 aa) initn: 934 init1: 691 opt: 908 Z-score: 939.0 bits: 184.3 E(85289): 1.5e-45 Smith-Waterman score: 974; 37.8% identity (66.9% similar) in 489 aa overlap (46-509:210-695) 20 30 40 50 60 70 pF1KE4 PRIMPPLLLLSAFIFLVSVLGGAPGHNPDRRTKMVSIHSLSELERLKLQETAYHELVARH : . : :.::::::: .:::.:...: NP_038 QSPPDSRGHPYVVWKSEGDFTWNSMSGRSVRLRSVPIQSLSELERARLQEVAFYQLQQDC 180 190 200 210 220 230 80 90 100 110 120 pF1KE4 FLSEFKPDRALPID---RPNTLDKWFLIL---RGQQRAVSHKTFGISLEEVLVNEFTRRK :: . ..: : : ..: : . : ..... ..::. : .:..:. . . NP_038 DLSC---QITIPKDGQKRKKSLRKKLDSLGKEKNKDKEFIPQAFGMPLSQVIANDRAYKL 240 250 260 270 280 290 130 140 150 160 170 180 pF1KE4 HLELTATMQVEEATGQAA----GRRRGNVVRRVFGRIRRFFSRRRNE---PTLPREFTRR . .: : . . :. : .: : . :. :: :. :. : NP_038 KQDLQRDEQKDASDFVASLLPFGNKRQNKELSSSNSSLSSTSETPNESTSPNTPEPAPRA 300 310 320 330 340 350 190 200 210 220 230 240 pF1KE4 GRRGAVSVDSLAELEDG-ALLLQTLQLSKISFPIGQRLLGSKRKMSLNPIAKQIPQVVEA ::::.::::...:.:. . ::..:::: . ... . .:.::::: .:.:..:.. NP_038 RRRGAMSVDSITDLDDNQSRLLEALQLSLPAEAQSKKEKARDKKLSLNPIYRQVPRLVDS 360 370 380 390 400 410 250 260 270 280 290 300 pF1KE4 CCQFIEKHGLSAVGIFTLEYSVQRVRQLREEFDQGLDVVLDDNQNVHDVAALLKEFFRDM ::: .:::::..:::: . : .::::::::::.:.:: :.....:::::::::::.::: NP_038 CCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVSLEEEHSVHDVAALLKEFLRDM 420 430 440 450 460 470 310 320 330 340 350 360 pF1KE4 KDSLLPDDLYMSFLLTATLKPQDQLSALQLLVYLMPPCHSDTLERLLKALHKITENCEDS : :: .:: .:. : :.:..::..::::.::.:::. :::.:::. : .... .:. NP_038 PDPLLTRELYTAFINTLLLEPEEQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVARHADDN 480 490 500 510 520 530 370 380 390 400 410 420 pF1KE4 IGIDGQLVPGNRMTSTNLALVFGSALLKKGKFGKRE-SRKTKLGIDHYVASVNVVRAMID :. ::: : ::.::: ::: .:: ::.: : . .: : ... .. .: . ::. ::. NP_038 ISKDGQEVTGNKMTSLNLATIFGPNLLHKQKSSDKEFSVQSSARAEESTAIIAVVQKMIE 540 550 560 570 580 590 430 440 450 460 470 480 pF1KE4 NWDVLFQVPPHIQRQVAKRVWKSSPEALDFIRRRNLRKIQSARIKMEEDALLSDPVETSA :...::.::: .: .: . ...:...:.. ::. . .: . . : .. ..:. NP_038 NYEALFMVPPDLQNEVLISLLETDPDVVDYLLRRKASQSSSPDMLQSEVSFSVGGRHSST 600 610 620 630 640 650 490 500 510 520 530 pF1KE4 EARAAVLAQSKPSDEGS---SE-------EPAVPSGTARSHDDEEGAGNPPIPEQDRPLL .. : .. .: :..: :: : :.:.:. . NP_038 DSNKASSGDISPYDNNSPVLSERSLLAMQEDAAPGGSEKLYRVPGQFMLVGHLSSSKSRE 660 670 680 690 700 710 540 pF1KE4 RVPREKEAKTGVSYFFP NP_038 SSPGPRLGKDLSEEPFDIWGTWHSTLKSGSKDPGMTGSSGDIFESSSLRAGPCSLSQGNL 720 730 740 750 760 770 >>XP_011531508 (OMIM: 610587) PREDICTED: rho GTPase-acti (620 aa) initn: 260 init1: 234 opt: 296 Z-score: 308.9 bits: 67.1 E(85289): 1.8e-10 Smith-Waterman score: 303; 26.9% identity (51.5% similar) in 361 aa overlap (181-536:97-403) 160 170 180 190 200 pF1KE4 RGNVVRRVFGRIRRFFSRRRNEPTLPREFTRRGRRGAVSV-DSLAELEDGALLLQTLQLS : :. . : . .: ::.:. . .:. . . XP_011 PGCTIKEIATNPEEAGKFVFEIIPASWDQNRMGQDSYVLMASSQAEMEEWVKFLRRVAGT 70 80 90 100 110 120 210 220 230 240 250 260 pF1KE4 KISFPIGQRLLGS-KRKMSLNPIAKQIPQVVEACCQFIEKHGLSAVGIFTLEYSVQRVRQ . .:::: . .....: . .: .:: : .:: .:: . ::: : . . :.: XP_011 PCGAVFGQRLDETVAYEQKFGP--HLVPILVEKCAEFILEHGRNEEGIFRLPGQDNLVKQ 130 140 150 160 170 180 270 280 290 300 310 320 pF1KE4 LREEFDQGLDVVLDDNQNVHDVAALLKEFFRDMKDSLLPDDLYMSFLLTATLKPQDQLSA ::. :: : .: . .:: ::.::: ..::. . ..: . : .::: . : :. .: XP_011 LRDAFDAGERPSFDRDTDVHTVASLLKLYLRDLPEPVVPWSQYEGFLLCGQLTNADEAKA 190 200 210 220 230 240 330 340 350 360 370 380 pF1KE4 LQLLVY---LMPPCHSDTLERLLKALHKITENCEDSIGIDGQLVPGNRMTSTNLALVFGS : :. ..: . . : . . ::.: :: .. :.:. ::: :.: XP_011 QQELMKQLSILPRDNYSLLSYICRFLHEIQLNC--AV---------NKMSVDNLATVIG- 250 260 270 280 290 390 400 410 420 430 440 pF1KE4 ALLKKGKFGKRESRKTKLGIDHYVASVNVVRAMIDNWDVLFQVPPHIQRQVAKRVWKSSP ::..:. ... :... :.::: .. XP_011 --------------------------VNLIRSKVEDPAVIMRGTPQIQRVMTM------- 300 310 450 460 470 480 490 500 pF1KE4 EALDFIRRRNLRKIQSARIKMEEDALLSDPVETSAEARAAVLAQSKPSDEGSSEEPAVPS .:: ... .: : . : .:: . . ::..: . . : :. . : XP_011 ----MIRDHEVLFPKSKDIPLSPPAQKNDP-KKAPVARSSV-GWDATEDLRISRTDSFSS 320 330 340 350 360 370 510 520 530 540 pF1KE4 GTARSHDDEEGAGNPPIPEQDRPLLRVPREKEAKTGVSYFFP :. : : .:. : . .::::: XP_011 MTSDS-DTTSPTGQQPSDAFPEDSSKVPREKPGDWKMQSRKRTQTLPNRKCFLTSAFQGA 380 390 400 410 420 430 XP_011 NSSKMEIFKNEFWSPSSEAKAGEGHRRTMSQDLRQLSDSQRTSTYDNVPSLPGSPGEEAS 440 450 460 470 480 490 >>XP_011531510 (OMIM: 610587) PREDICTED: rho GTPase-acti (620 aa) initn: 260 init1: 234 opt: 296 Z-score: 308.9 bits: 67.1 E(85289): 1.8e-10 Smith-Waterman score: 303; 26.9% identity (51.5% similar) in 361 aa overlap (181-536:97-403) 160 170 180 190 200 pF1KE4 RGNVVRRVFGRIRRFFSRRRNEPTLPREFTRRGRRGAVSV-DSLAELEDGALLLQTLQLS : :. . : . .: ::.:. . .:. . . XP_011 PGCTIKEIATNPEEAGKFVFEIIPASWDQNRMGQDSYVLMASSQAEMEEWVKFLRRVAGT 70 80 90 100 110 120 210 220 230 240 250 260 pF1KE4 KISFPIGQRLLGS-KRKMSLNPIAKQIPQVVEACCQFIEKHGLSAVGIFTLEYSVQRVRQ . .:::: . .....: . .: .:: : .:: .:: . ::: : . . :.: XP_011 PCGAVFGQRLDETVAYEQKFGP--HLVPILVEKCAEFILEHGRNEEGIFRLPGQDNLVKQ 130 140 150 160 170 180 270 280 290 300 310 320 pF1KE4 LREEFDQGLDVVLDDNQNVHDVAALLKEFFRDMKDSLLPDDLYMSFLLTATLKPQDQLSA ::. :: : .: . .:: ::.::: ..::. . ..: . : .::: . : :. .: XP_011 LRDAFDAGERPSFDRDTDVHTVASLLKLYLRDLPEPVVPWSQYEGFLLCGQLTNADEAKA 190 200 210 220 230 240 330 340 350 360 370 380 pF1KE4 LQLLVY---LMPPCHSDTLERLLKALHKITENCEDSIGIDGQLVPGNRMTSTNLALVFGS : :. ..: . . : . . ::.: :: .. :.:. ::: :.: XP_011 QQELMKQLSILPRDNYSLLSYICRFLHEIQLNC--AV---------NKMSVDNLATVIG- 250 260 270 280 290 390 400 410 420 430 440 pF1KE4 ALLKKGKFGKRESRKTKLGIDHYVASVNVVRAMIDNWDVLFQVPPHIQRQVAKRVWKSSP ::..:. ... :... :.::: .. XP_011 --------------------------VNLIRSKVEDPAVIMRGTPQIQRVMTM------- 300 310 450 460 470 480 490 500 pF1KE4 EALDFIRRRNLRKIQSARIKMEEDALLSDPVETSAEARAAVLAQSKPSDEGSSEEPAVPS .:: ... .: : . : .:: . . ::..: . . : :. . : XP_011 ----MIRDHEVLFPKSKDIPLSPPAQKNDP-KKAPVARSSV-GWDATEDLRISRTDSFSS 320 330 340 350 360 370 510 520 530 540 pF1KE4 GTARSHDDEEGAGNPPIPEQDRPLLRVPREKEAKTGVSYFFP :. : : .:. : . .::::: XP_011 MTSDS-DTTSPTGQQPSDAFPEDSSKVPREKPGDWKMQSRKRTQTLPNRKCFLTSAFQGA 380 390 400 410 420 430 XP_011 NSSKMEIFKNEFWSPSSEAKAGEGHRRTMSQDLRQLSDSQRTSTYDNVPSLPGSPGEEAS 440 450 460 470 480 490 547 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 02:29:05 2016 done: Sun Nov 6 02:29:07 2016 Total Scan time: 10.880 Total Display time: 0.080 Function used was FASTA [36.3.4 Apr, 2011]