Result of FASTA (ccds) for
pFN21AE2316
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE2316, 398 aa
1>>>pF1KE2316 398 - 398 aa - 398 aa
Library: human.CCDS.faa
18511270 residues in 32554 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.2012+/-0.000653; mu= 17.8632+/- 0.040
mean_var=62.1028+/-12.315, 0's: 0 Z-trim(110.1): 19 B-trim: 7 in 1/50
Lambda= 0.162749
statistics sampled from 11315 (11328) to 11315 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.721), E-opt: 0.2 (0.348), width: 16
Scan time: 2.480
The best scores are: opt bits E(32554)
CCDS14538.1 ATG4A gene_id:115201|Hs108|chrX ( 398) 2751 654.1 6.7e-188
CCDS46564.1 ATG4B gene_id:23192|Hs108|chr2 ( 393) 1502 360.8 1.3e-99
CCDS46565.1 ATG4B gene_id:23192|Hs108|chr2 ( 380) 1462 351.4 8.2e-97
CCDS14539.1 ATG4A gene_id:115201|Hs108|chrX ( 336) 1457 350.2 1.7e-96
CCDS623.1 ATG4C gene_id:84938|Hs108|chr1 ( 458) 349 90.1 4.5e-18
CCDS12241.1 ATG4D gene_id:84971|Hs108|chr19 ( 474) 256 68.3 1.7e-11
>>CCDS14538.1 ATG4A gene_id:115201|Hs108|chrX (398 aa)
initn: 2751 init1: 2751 opt: 2751 Z-score: 3486.9 bits: 654.1 E(32554): 6.7e-188
Smith-Waterman score: 2751; 100.0% identity (100.0% similar) in 398 aa overlap (1-398:1-398)
10 20 30 40 50 60
pF1KE2 MESVLSKYEDQITIFTDYLEEYPDTDELVWILGKQHLLKTEKSKLLSDISARLWFTYRRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS14 MESVLSKYEDQITIFTDYLEEYPDTDELVWILGKQHLLKTEKSKLLSDISARLWFTYRRK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 FSPIGGTGPSSDAGWGCMLRCGQMMLAQALICRHLGRDWSWEKQKEQPKEYQRILQCFLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS14 FSPIGGTGPSSDAGWGCMLRCGQMMLAQALICRHLGRDWSWEKQKEQPKEYQRILQCFLD
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 RKDCCYSIHQMAQMGVGEGKSIGEWFGPNTVAQVLKKLALFDEWNSLAVYVSMDNTVVIE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS14 RKDCCYSIHQMAQMGVGEGKSIGEWFGPNTVAQVLKKLALFDEWNSLAVYVSMDNTVVIE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 DIKKMCRVLPLSADTAGDRPPDSLTASNQSKGTSAYCSAWKPLLLIVPLRLGINQINPVY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS14 DIKKMCRVLPLSADTAGDRPPDSLTASNQSKGTSAYCSAWKPLLLIVPLRLGINQINPVY
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 VDAFKECFKMPQSLGALGGKPNNAYYFIGFLGDELIFLDPHTTQTFVDTEENGTVNDQTF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS14 VDAFKECFKMPQSLGALGGKPNNAYYFIGFLGDELIFLDPHTTQTFVDTEENGTVNDQTF
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 HCLQSPQRMNILNLDPSVALGFFCKEEKDFDNWCSLVQKEILKENLRMFELVQKHPSHWP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS14 HCLQSPQRMNILNLDPSVALGFFCKEEKDFDNWCSLVQKEILKENLRMFELVQKHPSHWP
310 320 330 340 350 360
370 380 390
pF1KE2 PFVPPAKPEVTTTGAEFIDSTEQLEEFDLEEDFEILSV
::::::::::::::::::::::::::::::::::::::
CCDS14 PFVPPAKPEVTTTGAEFIDSTEQLEEFDLEEDFEILSV
370 380 390
>>CCDS46564.1 ATG4B gene_id:23192|Hs108|chr2 (393 aa)
initn: 1512 init1: 877 opt: 1502 Z-score: 1902.1 bits: 360.8 E(32554): 1.3e-99
Smith-Waterman score: 1502; 55.8% identity (80.3% similar) in 391 aa overlap (15-398:13-393)
10 20 30 40 50 60
pF1KE2 MESVLSKYEDQITIFTDYLEEYPDTDELVWILGKQHLLKTEKSKLLSDISARLWFTYRRK
:... :..:.:.: :::::... . :::...:::...:::::::..
CCDS46 MDAATLTYDTLRFAEF-EDFPETSEPVWILGRKYSIFTEKDEILSDVASRLWFTYRKN
10 20 30 40 50
70 80 90 100 110 120
pF1KE2 FSPIGGTGPSSDAGWGCMLRCGQMMLAQALICRHLGRDWSWEKQKEQPKEYQRILQCFLD
: ::::::.::.:::::::::::..::::.:::::::: : ..:.:: : .:. :.:
CCDS46 FPAIGGTGPTSDTGWGCMLRCGQMIFAQALVCRHLGRDWRWTQRKRQPDSYFSVLNAFID
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE2 RKDCCYSIHQMAQMGVGEGKSIGEWFGPNTVAQVLKKLALFDEWNSLAVYVSMDNTVVIE
::: :::::.::::::::::::.:.:::::::::::::.:: :.::::...::::::.:
CCDS46 RKDSYYSIHQIAQMGVGEGKSIGQWYGPNTVAQVLKKLAVFDTWSSLAVHIAMDNTVVME
120 130 140 150 160 170
190 200 210 220 230
pF1KE2 DIKKMCRV-LPLSADTAGDRPPDSLTASN---QSKGTSAYCSAWKPLLLIVPLRLGINQI
.:...::. .: .. :: : :: : . .. : :.::.:..:::::...:
CCDS46 EIRRLCRTSVPCAGATA--FPADSDRHCNGFPAGAEVTNRPSPWRPLVLLIPLRLGLTDI
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE2 NPVYVDAFKECFKMPQSLGALGGKPNNAYYFIGFLGDELIFLDPHTTQTFVDTEENGTVN
: .::...:.:: ::::::..:::::.:.::::..:.:::.::::::: :. .. .
CCDS46 NEAYVETLKHCFMMPQSLGVIGGKPNSAHYFIGYVGEELIYLDPHTTQPAVEPTDGCFIP
240 250 260 270 280 290
300 310 320 330 340 350
pF1KE2 DQTFHCLQSPQRMNILNLDPSVALGFFCKEEKDFDNWCSLVQK-EILKENLRMFELVQKH
:..::: . : ::.: .::::.:.::::: : ::..::. :.: .: : :::::. .
CCDS46 DESFHCQHPPCRMSIAELDPSIAVGFFCKTEDDFNDWCQQVKKLSLLGGALPMFELVELQ
300 310 320 330 340 350
360 370 380 390
pF1KE2 PSHWPPFVPPAKPEVTTTGAEFIDSTEQLEEF-DLE-EDFEILSV
::: : :.: . . . : .:.::.: : : :::::::.
CCDS46 PSHL------ACPDVLNLSLDSSD-VERLERFFDSEDEDFEILSL
360 370 380 390
>>CCDS46565.1 ATG4B gene_id:23192|Hs108|chr2 (380 aa)
initn: 1482 init1: 877 opt: 1462 Z-score: 1851.6 bits: 351.4 E(32554): 8.2e-97
Smith-Waterman score: 1462; 57.6% identity (82.8% similar) in 349 aa overlap (15-358:13-358)
10 20 30 40 50 60
pF1KE2 MESVLSKYEDQITIFTDYLEEYPDTDELVWILGKQHLLKTEKSKLLSDISARLWFTYRRK
:... :..:.:.: :::::... . :::...:::...:::::::..
CCDS46 MDAATLTYDTLRFAEF-EDFPETSEPVWILGRKYSIFTEKDEILSDVASRLWFTYRKN
10 20 30 40 50
70 80 90 100 110 120
pF1KE2 FSPIGGTGPSSDAGWGCMLRCGQMMLAQALICRHLGRDWSWEKQKEQPKEYQRILQCFLD
: ::::::.::.:::::::::::..::::.:::::::: : ..:.:: : .:. :.:
CCDS46 FPAIGGTGPTSDTGWGCMLRCGQMIFAQALVCRHLGRDWRWTQRKRQPDSYFSVLNAFID
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE2 RKDCCYSIHQMAQMGVGEGKSIGEWFGPNTVAQVLKKLALFDEWNSLAVYVSMDNTVVIE
::: :::::.::::::::::::.:.:::::::::::::.:: :.::::...::::::.:
CCDS46 RKDSYYSIHQIAQMGVGEGKSIGQWYGPNTVAQVLKKLAVFDTWSSLAVHIAMDNTVVME
120 130 140 150 160 170
190 200 210 220 230
pF1KE2 DIKKMCRV-LPLSADTAGDRPPDSLTASN---QSKGTSAYCSAWKPLLLIVPLRLGINQI
.:...::. .: .. :: : :: : . .. : :.::.:..:::::...:
CCDS46 EIRRLCRTSVPCAGATA--FPADSDRHCNGFPAGAEVTNRPSPWRPLVLLIPLRLGLTDI
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE2 NPVYVDAFKECFKMPQSLGALGGKPNNAYYFIGFLGDELIFLDPHTTQTFVDTEENGTVN
: .::...:.:: ::::::..:::::.:.::::..:.:::.::::::: :. .. .
CCDS46 NEAYVETLKHCFMMPQSLGVIGGKPNSAHYFIGYVGEELIYLDPHTTQPAVEPTDGCFIP
240 250 260 270 280 290
300 310 320 330 340 350
pF1KE2 DQTFHCLQSPQRMNILNLDPSVALGFFCKEEKDFDNWCSLVQK-EILKENLRMFELVQKH
:..::: . : ::.: .::::.:.::::: : ::..::. :.: .: : :::::. .
CCDS46 DESFHCQHPPCRMSIAELDPSIAVGFFCKTEDDFNDWCQQVKKLSLLGGALPMFELVELQ
300 310 320 330 340 350
360 370 380 390
pF1KE2 PSHWPPFVPPAKPEVTTTGAEFIDSTEQLEEFDLEEDFEILSV
:::
CCDS46 PSHLACPDVLNLSLGESCQVQILLM
360 370 380
>>CCDS14539.1 ATG4A gene_id:115201|Hs108|chrX (336 aa)
initn: 2306 init1: 1453 opt: 1457 Z-score: 1846.0 bits: 350.2 E(32554): 1.7e-96
Smith-Waterman score: 2186; 84.4% identity (84.4% similar) in 398 aa overlap (1-398:1-336)
10 20 30 40 50 60
pF1KE2 MESVLSKYEDQITIFTDYLEEYPDTDELVWILGKQHLLKTEKSKLLSDISARLWFTYRRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS14 MESVLSKYEDQITIFTDYLEEYPDTDELVWILGKQHLLKTEKSKLLSDISARLWFTYRRK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 FSPIGGTGPSSDAGWGCMLRCGQMMLAQALICRHLGRDWSWEKQKEQPKEYQRILQCFLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS14 FSPIGGTGPSSDAGWGCMLRCGQMMLAQALICRHLGRDWSWEKQKEQPKEYQRILQCFLD
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 RKDCCYSIHQMAQMGVGEGKSIGEWFGPNTVAQVLKKLALFDEWNSLAVYVSMDNTVVIE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS14 RKDCCYSIHQMAQMGVGEGKSIGEWFGPNTVAQVLKKLALFDEWNSLAVYVSMDNTVVIE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 DIKKMCRVLPLSADTAGDRPPDSLTASNQSKGTSAYCSAWKPLLLIVPLRLGINQINPVY
::::::::::::::::::::::::::::::
CCDS14 DIKKMCRVLPLSADTAGDRPPDSLTASNQS------------------------------
190 200 210
250 260 270 280 290 300
pF1KE2 VDAFKECFKMPQSLGALGGKPNNAYYFIGFLGDELIFLDPHTTQTFVDTEENGTVNDQTF
::::::::::::::::::::::::::::
CCDS14 --------------------------------DELIFLDPHTTQTFVDTEENGTVNDQTF
220 230
310 320 330 340 350 360
pF1KE2 HCLQSPQRMNILNLDPSVALGFFCKEEKDFDNWCSLVQKEILKENLRMFELVQKHPSHWP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS14 HCLQSPQRMNILNLDPSVALGFFCKEEKDFDNWCSLVQKEILKENLRMFELVQKHPSHWP
240 250 260 270 280 290
370 380 390
pF1KE2 PFVPPAKPEVTTTGAEFIDSTEQLEEFDLEEDFEILSV
::::::::::::::::::::::::::::::::::::::
CCDS14 PFVPPAKPEVTTTGAEFIDSTEQLEEFDLEEDFEILSV
300 310 320 330
>>CCDS623.1 ATG4C gene_id:84938|Hs108|chr1 (458 aa)
initn: 632 init1: 215 opt: 349 Z-score: 438.0 bits: 90.1 E(32554): 4.5e-18
Smith-Waterman score: 585; 29.6% identity (54.7% similar) in 422 aa overlap (34-391:68-454)
10 20 30 40 50 60
pF1KE2 VLSKYEDQITIFTDYLEEYPDTDELVWILGKQHLLKTEKSKLLSDISARLWFTYRRKFSP
..:.. . .. .:. .:.:.:::..:
CCDS62 NSPVLLLGKCYHFKYEDEDKTLPAESGCTIEDHVIAGNVEEFRKDFISRIWLTYREEFPQ
40 50 60 70 80 90
70 80 90 100
pF1KE2 IGGTGPSSDAGWGCMLRCGQMMLAQALICRHLGRDWSW----------------------
: :.. ..: :::: :: :::.:::.:: . ::: :.:
CCDS62 IEGSALTTDCGWGCTLRTGQMLLAQGLILHFLGRAWTWPDALNIENSDSESWTSHTVKKF
100 110 120 130 140 150
110 120 130
pF1KE2 ----------EKQKEQP----KE---------------YQR-ILQCFLDRKDCCYSIHQM
:.. . : :: :.: :.. : : ...::.
CCDS62 TASFEASLSGEREFKTPTISLKETIGKYSDDHEMRNEVYHRKIISWFGDSPLALFGLHQL
160 170 180 190 200 210
140 150 160 170 180
pF1KE2 AQMGVGEGKSIGEWFGPNTVAQVLKKL---ALFDEWNSLAVYVSMDNTVVIEDIKKMCRV
..: ::. :.:.:: .::..:.: : . .....::..: :: :.
CCDS62 IEYGKKSGKKAGDWYGPAVVAHILRKAVEEARHPDLQGITIYVAQDCTVYNSDVI-----
220 230 240 250 260 270
190 200 210 220 230 240
pF1KE2 LPLSADTAGDRPPDSLTASNQSKGTSAYCSAWKPLLLIVPLRLGINQINPVYVDAFKECF
:. :.:..: . : ....::.::: .. : :.. : .
CCDS62 ---------DKQSASMTSDNADD---------KAVIILVPVRLGGERTNTDYLEFVKGIL
280 290 300 310
250 260 270 280 290 300
pF1KE2 KMPQSLGALGGKPNNAYYFIGFLGDELIFLDPHTTQTFVDTEENGTVND---QTFHCLQS
.. .: .::::...::: :: : ::..::: :.:::. ...: .:::: :
CCDS62 SLEYCVGIIGGKPKQSYYFAGFQDDSLIYMDPHYCQSFVDV----SIKDFPLETFHC-PS
320 330 340 350 360
310 320 330 340 350 360
pF1KE2 PQRMNILNLDPSVALGFFCKEEKDFDNWCSLVQKEIL---KENLRMFELVQKHPSHWPPF
:..:.. ..::: ..::.:.. .:: . : . ::. .: .:. : . :
CCDS62 PKKMSFRKMDPSCTIGFYCRNVQDFKRASEEITKMLKFSSKEKYPLFTFVNGHSRDYD-F
370 380 390 400 410 420
370 380 390
pF1KE2 VPPAKPEVTTTGAEFI---DSTEQLEEFDLEEDFEILSV
. :::. : . : .::..:. ::
CCDS62 TS------TTTNEEDLFSEDEKKQLKRFSTEEFVLL
430 440 450
>>CCDS12241.1 ATG4D gene_id:84971|Hs108|chr19 (474 aa)
initn: 673 init1: 254 opt: 256 Z-score: 319.7 bits: 68.3 E(32554): 1.7e-11
Smith-Waterman score: 654; 31.5% identity (57.3% similar) in 368 aa overlap (29-355:94-434)
10 20 30 40 50
pF1KE2 MESVLSKYEDQITIFTDYLEEYPDTDELVWILGKQHLLKTEKS--KLLSDISARLWFT
. . :... .. : . .. :. .:::.:
CCDS12 KFKAKFLTAWNNVKYGWVVKSRTSFSKISSIHLCGRRYRFEGEGDIQRFQRDFVSRLWLT
70 80 90 100 110 120
60 70 80 90 100
pF1KE2 YRRKFSPIGGTGPSSDAGWGCMLRCGQMMLAQALICRHLGRDWSWEK-------------
::: : :. : .:: ::::::: :::::::.:. . : :::.: .
CCDS12 YRRDFPPLPGGCLTSDCGWGCMLRSGQMMLAQGLLLHFLPRDWTWAEGMGLGPPELSGSA
130 140 150 160 170 180
110 120 130 140
pF1KE2 ---------------------QKEQPKEYQRILQCFLDRKDCCYSIHQMAQMGVGEGKSI
. :: .....:.. : :. ...:.....: . ::.
CCDS12 SPSRYHGPARWMPPRWAQGAPELEQERRHRQIVSWFADHPRAPFGLHRLVELGQSSGKKA
190 200 210 220 230 240
150 160 170 180 190 200
pF1KE2 GEWFGPNTVAQVLKK-LALFDEWNSLAVYVSMDNTVVIEDIKKMCRVLPLSADTAGDRPP
:.:.::. ::..:.: . .. . :.::::.: :: :. .. ::
CCDS12 GDWYGPSLVAHILRKAVESCSDVTRLVVYVSQDCTVYKADVARLVA-----------RPD
250 260 270 280 290
210 220 230 240 250 260
pF1KE2 DSLTASNQSKGTSAYCSAWKPLLLIVPLRLGINQINPVYVDAFKECFKMPQSLGALGGKP
. . :: ....::.::: . .::::: :: .. :: .::::
CCDS12 PT--------------AEWKSVVILVPVRLGGETLNPVYVPCVKELLRCELCLGIMGGKP
300 310 320 330
270 280 290 300 310 320
pF1KE2 NNAYYFIGFLGDELIFLDPHTTQTFVDTEENGTVNDQTFHCLQSPQRMNILNLDPSVALG
.. ::::. : :..:::: : ::. . . ..::: ::..: . ..::: ..:
CCDS12 RHSLYFIGYQDDFLLYLDPHYCQPTVDVSQ-ADFPLESFHCT-SPRKMAFAKMDPSCTVG
340 350 360 370 380 390
330 340 350 360 370
pF1KE2 FFCKEEKDFDNWCSLVQKEILK----ENLRMFELVQKHPSHWPPFVPPAKPEVTTTGAEF
:. ..:.:.. :: . . . . : :: :.. :
CCDS12 FYAGDRKEFETLCSELTRVLSSSSATERYPMFTLAEGHAQDHSLDDLCSQLAQPTLRLPR
400 410 420 430 440 450
380 390
pF1KE2 IDSTEQLEEFDLEEDFEILSV
CCDS12 TGRLLRAKRPSSEDFVFL
460 470
398 residues in 1 query sequences
18511270 residues in 32554 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 12:45:24 2016 done: Sun Nov 6 12:45:24 2016
Total Scan time: 2.480 Total Display time: 0.010
Function used was FASTA [36.3.4 Apr, 2011]