FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE1609, 114 aa 1>>>pF1KE1609 114 - 114 aa - 114 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.7280+/-0.000253; mu= 13.5598+/- 0.016 mean_var=58.1226+/-11.731, 0's: 0 Z-trim(120.8): 12 B-trim: 144 in 1/53 Lambda= 0.168229 statistics sampled from 36546 (36558) to 36546 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.799), E-opt: 0.2 (0.429), width: 16 Scan time: 4.510 The best scores are: opt bits E(85289) NP_003013 (OMIM: 300190) SH3 domain-binding glutam ( 114) 747 188.3 2.3e-48 XP_011529316 (OMIM: 300190) PREDICTED: SH3 domain- ( 151) 662 167.7 4.7e-42 XP_011529315 (OMIM: 300190) PREDICTED: SH3 domain- ( 176) 662 167.8 5.3e-42 NP_001304669 (OMIM: 602230) SH3 domain-binding glu ( 208) 509 130.7 9.1e-31 NP_031367 (OMIM: 602230) SH3 domain-binding glutam ( 239) 502 129.1 3.3e-30 XP_016866833 (OMIM: 615678) PREDICTED: SH3 domain- ( 107) 443 114.5 3.6e-26 NP_113657 (OMIM: 615678) SH3 domain-binding glutam ( 107) 443 114.5 3.6e-26 XP_011534467 (OMIM: 615678) PREDICTED: SH3 domain- ( 99) 375 98.0 3.1e-21 NP_001304670 (OMIM: 602230) SH3 domain-binding glu ( 97) 279 74.7 3.2e-14 NP_001304671 (OMIM: 602230) SH3 domain-binding glu ( 128) 272 73.0 1.3e-13 NP_001001713 (OMIM: 602230) SH3 domain-binding glu ( 128) 272 73.0 1.3e-13 NP_112576 (OMIM: 615679) SH3 domain-binding glutam ( 93) 184 51.6 2.7e-07 >>NP_003013 (OMIM: 300190) SH3 domain-binding glutamic a (114 aa) initn: 747 init1: 747 opt: 747 Z-score: 989.3 bits: 188.3 E(85289): 2.3e-48 Smith-Waterman score: 747; 100.0% identity (100.0% similar) in 114 aa overlap (1-114:1-114) 10 20 30 40 50 60 pF1KE1 MVIRVYIASSSGSTAIKKKQQDVLGFLEANKIGFEEKDIAANEENRKWMRENVPENSRPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 MVIRVYIASSSGSTAIKKKQQDVLGFLEANKIGFEEKDIAANEENRKWMRENVPENSRPA 10 20 30 40 50 60 70 80 90 100 110 pF1KE1 TGYPLPPQIFNESQYRGDYDAFFEARENNAVYAFLGLTAPPGSKEAEVQAKQQA :::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 TGYPLPPQIFNESQYRGDYDAFFEARENNAVYAFLGLTAPPGSKEAEVQAKQQA 70 80 90 100 110 >>XP_011529316 (OMIM: 300190) PREDICTED: SH3 domain-bind (151 aa) initn: 662 init1: 662 opt: 662 Z-score: 876.0 bits: 167.7 E(85289): 4.7e-42 Smith-Waterman score: 662; 100.0% identity (100.0% similar) in 99 aa overlap (16-114:53-151) 10 20 30 40 pF1KE1 MVIRVYIASSSGSTAIKKKQQDVLGFLEANKIGFEEKDIAANEEN :::::::::::::::::::::::::::::: XP_011 TIYMHTHKSFINLTTIYMHTHKTFVRTQNQIKKKQQDVLGFLEANKIGFEEKDIAANEEN 30 40 50 60 70 80 50 60 70 80 90 100 pF1KE1 RKWMRENVPENSRPATGYPLPPQIFNESQYRGDYDAFFEARENNAVYAFLGLTAPPGSKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RKWMRENVPENSRPATGYPLPPQIFNESQYRGDYDAFFEARENNAVYAFLGLTAPPGSKE 90 100 110 120 130 140 110 pF1KE1 AEVQAKQQA ::::::::: XP_011 AEVQAKQQA 150 >>XP_011529315 (OMIM: 300190) PREDICTED: SH3 domain-bind (176 aa) initn: 662 init1: 662 opt: 662 Z-score: 875.1 bits: 167.8 E(85289): 5.3e-42 Smith-Waterman score: 662; 100.0% identity (100.0% similar) in 99 aa overlap (16-114:78-176) 10 20 30 40 pF1KE1 MVIRVYIASSSGSTAIKKKQQDVLGFLEANKIGFEEKDIAANEEN :::::::::::::::::::::::::::::: XP_011 TIYMHTHKSFINLTTIYMHTHKTFVRTQNQIKKKQQDVLGFLEANKIGFEEKDIAANEEN 50 60 70 80 90 100 50 60 70 80 90 100 pF1KE1 RKWMRENVPENSRPATGYPLPPQIFNESQYRGDYDAFFEARENNAVYAFLGLTAPPGSKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RKWMRENVPENSRPATGYPLPPQIFNESQYRGDYDAFFEARENNAVYAFLGLTAPPGSKE 110 120 130 140 150 160 110 pF1KE1 AEVQAKQQA ::::::::: XP_011 AEVQAKQQA 170 >>NP_001304669 (OMIM: 602230) SH3 domain-binding glutami (208 aa) initn: 554 init1: 509 opt: 509 Z-score: 673.4 bits: 130.7 E(85289): 9.1e-31 Smith-Waterman score: 509; 66.4% identity (87.9% similar) in 107 aa overlap (1-107:64-170) 10 20 30 pF1KE1 MVIRVYIASSSGSTAIKKKQQDVLGFLEAN :::.:..:.:::: ::.::::.:.:::::: NP_001 LACLCHCQDLSSGAFPNRGVLGGVLFPTVEMVIKVFVATSSGSIAIRKKQQEVVGFLEAN 40 50 60 70 80 90 40 50 60 70 80 90 pF1KE1 KIGFEEKDIAANEENRKWMRENVPENSRPATGYPLPPQIFNESQYRGDYDAFFEARENNA :: :.: :::..:.::.::::::: ...: .: ::::::::: :: ::.:.:: :.:.: NP_001 KIDFKELDIAGDEDNRRWMRENVPGEKKPQNGIPLPPQIFNEEQYCGDFDSFFSAKEENI 100 110 120 130 140 150 100 110 pF1KE1 VYAFLGLTAPPGSKEAEVQAKQQA .:.::::. :: ::: : NP_001 IYSFLGLAPPPDSKEEEGETATEETEEIAMEGAEGEAEEEEETAEGEEPGEDEDS 160 170 180 190 200 >>NP_031367 (OMIM: 602230) SH3 domain-binding glutamic a (239 aa) initn: 519 init1: 502 opt: 502 Z-score: 663.3 bits: 129.1 E(85289): 3.3e-30 Smith-Waterman score: 502; 65.4% identity (87.9% similar) in 107 aa overlap (1-107:64-170) 10 20 30 pF1KE1 MVIRVYIASSSGSTAIKKKQQDVLGFLEAN :::.:..:.:::: ::.::::.:.:::::: NP_031 LACLCHCQDLSSGAFPNRGVLGGVLFPTVEMVIKVFVATSSGSIAIRKKQQEVVGFLEAN 40 50 60 70 80 90 40 50 60 70 80 90 pF1KE1 KIGFEEKDIAANEENRKWMRENVPENSRPATGYPLPPQIFNESQYRGDYDAFFEARENNA :: :.: :::..:.::.::::::: ...: .: ::::::::: :: ::.:.:: :.:.: NP_031 KIDFKELDIAGDEDNRRWMRENVPGEKKPQNGIPLPPQIFNEEQYCGDFDSFFSAKEENI 100 110 120 130 140 150 100 110 pF1KE1 VYAFLGLTAPPGSKEAEVQAKQQA .:.::::. :: :: .: NP_031 IYSFLGLAPPPDSKGSEKAEEGGETEAQKEGSEDVGNLPEAQEKNEEEGETATEETEEIA 160 170 180 190 200 210 >>XP_016866833 (OMIM: 615678) PREDICTED: SH3 domain-bind (107 aa) initn: 442 init1: 442 opt: 443 Z-score: 590.9 bits: 114.5 E(85289): 3.6e-26 Smith-Waterman score: 443; 63.6% identity (86.0% similar) in 107 aa overlap (1-107:1-106) 10 20 30 40 50 60 pF1KE1 MVIRVYIASSSGSTAIKKKQQDVLGFLEANKIGFEEKDIAANEENRKWMRENVPENSRPA :::::.:::::: .:::::::::. ::::::: ::: ::. .::.:.:: .::: ...:. XP_016 MVIRVFIASSSGFVAIKKKQQDVVRFLEANKIEFEEVDITMSEEQRQWMYKNVPPEKKPT 10 20 30 40 50 60 70 80 90 100 110 pF1KE1 TGYPLPPQIFNESQYRGDYDAFFEARENNAVYAFLGLTAPPGSKEAEVQAKQQA : :::::::: ..: ::::.:::..:.:.:..:::: : ...:: XP_016 QGNPLPPQIFNGDRYCGDYDSFFESKESNTVFSFLGLK-PRLASKAEP 70 80 90 100 >>NP_113657 (OMIM: 615678) SH3 domain-binding glutamic a (107 aa) initn: 442 init1: 442 opt: 443 Z-score: 590.9 bits: 114.5 E(85289): 3.6e-26 Smith-Waterman score: 443; 63.6% identity (86.0% similar) in 107 aa overlap (1-107:1-106) 10 20 30 40 50 60 pF1KE1 MVIRVYIASSSGSTAIKKKQQDVLGFLEANKIGFEEKDIAANEENRKWMRENVPENSRPA :::::.:::::: .:::::::::. ::::::: ::: ::. .::.:.:: .::: ...:. NP_113 MVIRVFIASSSGFVAIKKKQQDVVRFLEANKIEFEEVDITMSEEQRQWMYKNVPPEKKPT 10 20 30 40 50 60 70 80 90 100 110 pF1KE1 TGYPLPPQIFNESQYRGDYDAFFEARENNAVYAFLGLTAPPGSKEAEVQAKQQA : :::::::: ..: ::::.:::..:.:.:..:::: : ...:: NP_113 QGNPLPPQIFNGDRYCGDYDSFFESKESNTVFSFLGLK-PRLASKAEP 70 80 90 100 >>XP_011534467 (OMIM: 615678) PREDICTED: SH3 domain-bind (99 aa) initn: 374 init1: 374 opt: 375 Z-score: 502.2 bits: 98.0 E(85289): 3.1e-21 Smith-Waterman score: 375; 60.9% identity (84.8% similar) in 92 aa overlap (16-107:8-98) 10 20 30 40 50 60 pF1KE1 MVIRVYIASSSGSTAIKKKQQDVLGFLEANKIGFEEKDIAANEENRKWMRENVPENSRPA ::::::::. ::::::: ::: ::. .::.:.:: .::: ...:. XP_011 MTNSRQKIKKKQQDVVRFLEANKIEFEEVDITMSEEQRQWMYKNVPPEKKPT 10 20 30 40 50 70 80 90 100 110 pF1KE1 TGYPLPPQIFNESQYRGDYDAFFEARENNAVYAFLGLTAPPGSKEAEVQAKQQA : :::::::: ..: ::::.:::..:.:.:..:::: : ...:: XP_011 QGNPLPPQIFNGDRYCGDYDSFFESKESNTVFSFLGLK-PRLASKAEP 60 70 80 90 >>NP_001304670 (OMIM: 602230) SH3 domain-binding glutami (97 aa) initn: 307 init1: 279 opt: 279 Z-score: 376.4 bits: 74.7 E(85289): 3.2e-14 Smith-Waterman score: 279; 64.4% identity (83.1% similar) in 59 aa overlap (49-107:1-59) 20 30 40 50 60 70 pF1KE1 KQQDVLGFLEANKIGFEEKDIAANEENRKWMRENVPENSRPATGYPLPPQIFNESQYRGD :::::: ...: .: ::::::::: :: :: NP_001 MRENVPGEKKPQNGIPLPPQIFNEEQYCGD 10 20 30 80 90 100 110 pF1KE1 YDAFFEARENNAVYAFLGLTAPPGSKEAEVQAKQQA .:.:: :.:.: .:.::::. :: ::: : NP_001 FDSFFSAKEENIIYSFLGLAPPPDSKEEEGETATEETEEIAMEGAEGEAEEEEETAEGEE 40 50 60 70 80 90 >>NP_001304671 (OMIM: 602230) SH3 domain-binding glutami (128 aa) initn: 285 init1: 272 opt: 272 Z-score: 365.5 bits: 73.0 E(85289): 1.3e-13 Smith-Waterman score: 272; 62.7% identity (83.1% similar) in 59 aa overlap (49-107:1-59) 20 30 40 50 60 70 pF1KE1 KQQDVLGFLEANKIGFEEKDIAANEENRKWMRENVPENSRPATGYPLPPQIFNESQYRGD :::::: ...: .: ::::::::: :: :: NP_001 MRENVPGEKKPQNGIPLPPQIFNEEQYCGD 10 20 30 80 90 100 110 pF1KE1 YDAFFEARENNAVYAFLGLTAPPGSKEAEVQAKQQA .:.:: :.:.: .:.::::. :: :: .: NP_001 FDSFFSAKEENIIYSFLGLAPPPDSKGSEKAEEGGETEAQKEGSEDVGNLPEAQEKNEEE 40 50 60 70 80 90 114 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 12:45:58 2016 done: Sun Nov 6 12:45:59 2016 Total Scan time: 4.510 Total Display time: -0.030 Function used was FASTA [36.3.4 Apr, 2011]