FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE2746, 587 aa 1>>>pF1KE2746 587 - 587 aa - 587 aa Library: human.CCDS.faa 18921897 residues in 33420 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.6358+/-0.000865; mu= 16.8044+/- 0.052 mean_var=66.7608+/-13.503, 0's: 0 Z-trim(106.7): 20 B-trim: 105 in 1/50 Lambda= 0.156969 statistics sampled from 9222 (9235) to 9222 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.653), E-opt: 0.2 (0.276), width: 16 Scan time: 1.490 The best scores are: opt bits E(33420) CCDS14366.1 ALAS2 gene_id:212|Hs109|chrX ( 587) 3968 907.7 0 CCDS35303.1 ALAS2 gene_id:212|Hs109|chrX ( 550) 3042 698.0 8.1e-201 CCDS43960.1 ALAS2 gene_id:212|Hs109|chrX ( 574) 3042 698.0 8.4e-201 CCDS2847.1 ALAS1 gene_id:211|Hs109|chr3 ( 640) 2334 537.7 1.7e-152 CCDS13957.1 GCAT gene_id:23464|Hs109|chr22 ( 419) 767 182.8 7.8e-46 CCDS54527.1 GCAT gene_id:23464|Hs109|chr22 ( 445) 767 182.8 8.2e-46 CCDS13115.2 SPTLC3 gene_id:55304|Hs109|chr20 ( 552) 437 108.1 3.1e-23 CCDS9865.1 SPTLC2 gene_id:9517|Hs109|chr14 ( 562) 360 90.7 5.6e-18 CCDS6692.1 SPTLC1 gene_id:10558|Hs109|chr9 ( 473) 255 66.9 7e-11 >>CCDS14366.1 ALAS2 gene_id:212|Hs109|chrX (587 aa) initn: 3968 init1: 3968 opt: 3968 Z-score: 4851.8 bits: 907.7 E(33420): 0 Smith-Waterman score: 3968; 100.0% identity (100.0% similar) in 587 aa overlap (1-587:1-587) 10 20 30 40 50 60 pF1KE2 MVTAAMLLQCCPVLARGPTSLLGKVVKTHQFLFGIGRCPILATQGPNCSQIHLKATKAGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS14 MVTAAMLLQCCPVLARGPTSLLGKVVKTHQFLFGIGRCPILATQGPNCSQIHLKATKAGG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 DSPSWAKGHCPFMLSELQDGKSKIVQKAAPEVQEDVKAFKTDLPSSLVSVSLRKPFSGPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS14 DSPSWAKGHCPFMLSELQDGKSKIVQKAAPEVQEDVKAFKTDLPSSLVSVSLRKPFSGPQ 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 EQEQISGKVTHLIQNNMPGNYVFSYDQFFRDKIMEKKQDHTYRVFKTVNRWADAYPFAQH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS14 EQEQISGKVTHLIQNNMPGNYVFSYDQFFRDKIMEKKQDHTYRVFKTVNRWADAYPFAQH 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 FSEASVASKDVSVWCSNDYLGMSRHPQVLQATQETLQRHGAGAGGTRNISGTSKFHVELE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS14 FSEASVASKDVSVWCSNDYLGMSRHPQVLQATQETLQRHGAGAGGTRNISGTSKFHVELE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 QELAELHQKDSALLFSSCFVANDSTLFTLAKILPGCEIYSDAGNHASMIQGIRNSGAAKF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS14 QELAELHQKDSALLFSSCFVANDSTLFTLAKILPGCEIYSDAGNHASMIQGIRNSGAAKF 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 VFRHNDPDHLKKLLEKSNPKIPKIVAFETVHSMDGAICPLEELCDVSHQYGALTFVDEVH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS14 VFRHNDPDHLKKLLEKSNPKIPKIVAFETVHSMDGAICPLEELCDVSHQYGALTFVDEVH 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 AVGLYGSRGAGIGERDGIMHKIDIISGTLGKAFGCVGGYIASTRDLVDMVRSYAAGFIFT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS14 AVGLYGSRGAGIGERDGIMHKIDIISGTLGKAFGCVGGYIASTRDLVDMVRSYAAGFIFT 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 TSLPPMVLSGALESVRLLKGEEGQALRRAHQRNVKHMRQLLMDRGLPVIPCPSHIIPIRV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS14 TSLPPMVLSGALESVRLLKGEEGQALRRAHQRNVKHMRQLLMDRGLPVIPCPSHIIPIRV 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE2 GNAALNSKLCDLLLSKHGIYVQAINYPTVPRGEELLRLAPSPHHSPQMMEDFVEKLLLAW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS14 GNAALNSKLCDLLLSKHGIYVQAINYPTVPRGEELLRLAPSPHHSPQMMEDFVEKLLLAW 490 500 510 520 530 540 550 560 570 580 pF1KE2 TAVGLPLQDVSVAACNFCRRPVHFELMSEWERSYFGNMGPQYVTTYA ::::::::::::::::::::::::::::::::::::::::::::::: CCDS14 TAVGLPLQDVSVAACNFCRRPVHFELMSEWERSYFGNMGPQYVTTYA 550 560 570 580 >>CCDS35303.1 ALAS2 gene_id:212|Hs109|chrX (550 aa) initn: 3712 init1: 3034 opt: 3042 Z-score: 3719.0 bits: 698.0 E(33420): 8.1e-201 Smith-Waterman score: 3642; 93.7% identity (93.7% similar) in 587 aa overlap (1-587:1-550) 10 20 30 40 50 60 pF1KE2 MVTAAMLLQCCPVLARGPTSLLGKVVKTHQFLFGIGRCPILATQGPNCSQIHLKATKAGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS35 MVTAAMLLQCCPVLARGPTSLLGKVVKTHQFLFGIGRCPILATQGPNCSQIHLKATKAGG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 DSPSWAKGHCPFMLSELQDGKSKIVQKAAPEVQEDVKAFKTDLPSSLVSVSLRKPFSGPQ ::::::::::::::::::::::::::::::::::::::::: CCDS35 DSPSWAKGHCPFMLSELQDGKSKIVQKAAPEVQEDVKAFKT------------------- 70 80 90 100 130 140 150 160 170 180 pF1KE2 EQEQISGKVTHLIQNNMPGNYVFSYDQFFRDKIMEKKQDHTYRVFKTVNRWADAYPFAQH :::::::::::::::::::::::::::::::::::::::::: CCDS35 ------------------GNYVFSYDQFFRDKIMEKKQDHTYRVFKTVNRWADAYPFAQH 110 120 130 140 190 200 210 220 230 240 pF1KE2 FSEASVASKDVSVWCSNDYLGMSRHPQVLQATQETLQRHGAGAGGTRNISGTSKFHVELE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS35 FSEASVASKDVSVWCSNDYLGMSRHPQVLQATQETLQRHGAGAGGTRNISGTSKFHVELE 150 160 170 180 190 200 250 260 270 280 290 300 pF1KE2 QELAELHQKDSALLFSSCFVANDSTLFTLAKILPGCEIYSDAGNHASMIQGIRNSGAAKF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS35 QELAELHQKDSALLFSSCFVANDSTLFTLAKILPGCEIYSDAGNHASMIQGIRNSGAAKF 210 220 230 240 250 260 310 320 330 340 350 360 pF1KE2 VFRHNDPDHLKKLLEKSNPKIPKIVAFETVHSMDGAICPLEELCDVSHQYGALTFVDEVH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS35 VFRHNDPDHLKKLLEKSNPKIPKIVAFETVHSMDGAICPLEELCDVSHQYGALTFVDEVH 270 280 290 300 310 320 370 380 390 400 410 420 pF1KE2 AVGLYGSRGAGIGERDGIMHKIDIISGTLGKAFGCVGGYIASTRDLVDMVRSYAAGFIFT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS35 AVGLYGSRGAGIGERDGIMHKIDIISGTLGKAFGCVGGYIASTRDLVDMVRSYAAGFIFT 330 340 350 360 370 380 430 440 450 460 470 480 pF1KE2 TSLPPMVLSGALESVRLLKGEEGQALRRAHQRNVKHMRQLLMDRGLPVIPCPSHIIPIRV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS35 TSLPPMVLSGALESVRLLKGEEGQALRRAHQRNVKHMRQLLMDRGLPVIPCPSHIIPIRV 390 400 410 420 430 440 490 500 510 520 530 540 pF1KE2 GNAALNSKLCDLLLSKHGIYVQAINYPTVPRGEELLRLAPSPHHSPQMMEDFVEKLLLAW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS35 GNAALNSKLCDLLLSKHGIYVQAINYPTVPRGEELLRLAPSPHHSPQMMEDFVEKLLLAW 450 460 470 480 490 500 550 560 570 580 pF1KE2 TAVGLPLQDVSVAACNFCRRPVHFELMSEWERSYFGNMGPQYVTTYA ::::::::::::::::::::::::::::::::::::::::::::::: CCDS35 TAVGLPLQDVSVAACNFCRRPVHFELMSEWERSYFGNMGPQYVTTYA 510 520 530 540 550 >>CCDS43960.1 ALAS2 gene_id:212|Hs109|chrX (574 aa) initn: 3712 init1: 3034 opt: 3042 Z-score: 3718.7 bits: 698.0 E(33420): 8.4e-201 Smith-Waterman score: 3642; 93.7% identity (93.7% similar) in 587 aa overlap (1-587:25-574) 10 20 30 pF1KE2 MVTAAMLLQCCPVLARGPTSLLGKVVKTHQFLFGIG :::::::::::::::::::::::::::::::::::: CCDS43 MRGGEVALGWNKKKRLFCEDFRFKMVTAAMLLQCCPVLARGPTSLLGKVVKTHQFLFGIG 10 20 30 40 50 60 40 50 60 70 80 90 pF1KE2 RCPILATQGPNCSQIHLKATKAGGDSPSWAKGHCPFMLSELQDGKSKIVQKAAPEVQEDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS43 RCPILATQGPNCSQIHLKATKAGGDSPSWAKGHCPFMLSELQDGKSKIVQKAAPEVQEDV 70 80 90 100 110 120 100 110 120 130 140 150 pF1KE2 KAFKTDLPSSLVSVSLRKPFSGPQEQEQISGKVTHLIQNNMPGNYVFSYDQFFRDKIMEK ::::: :::::::::::::::::: CCDS43 KAFKT-------------------------------------GNYVFSYDQFFRDKIMEK 130 140 160 170 180 190 200 210 pF1KE2 KQDHTYRVFKTVNRWADAYPFAQHFSEASVASKDVSVWCSNDYLGMSRHPQVLQATQETL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS43 KQDHTYRVFKTVNRWADAYPFAQHFSEASVASKDVSVWCSNDYLGMSRHPQVLQATQETL 150 160 170 180 190 200 220 230 240 250 260 270 pF1KE2 QRHGAGAGGTRNISGTSKFHVELEQELAELHQKDSALLFSSCFVANDSTLFTLAKILPGC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS43 QRHGAGAGGTRNISGTSKFHVELEQELAELHQKDSALLFSSCFVANDSTLFTLAKILPGC 210 220 230 240 250 260 280 290 300 310 320 330 pF1KE2 EIYSDAGNHASMIQGIRNSGAAKFVFRHNDPDHLKKLLEKSNPKIPKIVAFETVHSMDGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS43 EIYSDAGNHASMIQGIRNSGAAKFVFRHNDPDHLKKLLEKSNPKIPKIVAFETVHSMDGA 270 280 290 300 310 320 340 350 360 370 380 390 pF1KE2 ICPLEELCDVSHQYGALTFVDEVHAVGLYGSRGAGIGERDGIMHKIDIISGTLGKAFGCV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS43 ICPLEELCDVSHQYGALTFVDEVHAVGLYGSRGAGIGERDGIMHKIDIISGTLGKAFGCV 330 340 350 360 370 380 400 410 420 430 440 450 pF1KE2 GGYIASTRDLVDMVRSYAAGFIFTTSLPPMVLSGALESVRLLKGEEGQALRRAHQRNVKH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS43 GGYIASTRDLVDMVRSYAAGFIFTTSLPPMVLSGALESVRLLKGEEGQALRRAHQRNVKH 390 400 410 420 430 440 460 470 480 490 500 510 pF1KE2 MRQLLMDRGLPVIPCPSHIIPIRVGNAALNSKLCDLLLSKHGIYVQAINYPTVPRGEELL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS43 MRQLLMDRGLPVIPCPSHIIPIRVGNAALNSKLCDLLLSKHGIYVQAINYPTVPRGEELL 450 460 470 480 490 500 520 530 540 550 560 570 pF1KE2 RLAPSPHHSPQMMEDFVEKLLLAWTAVGLPLQDVSVAACNFCRRPVHFELMSEWERSYFG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS43 RLAPSPHHSPQMMEDFVEKLLLAWTAVGLPLQDVSVAACNFCRRPVHFELMSEWERSYFG 510 520 530 540 550 560 580 pF1KE2 NMGPQYVTTYA ::::::::::: CCDS43 NMGPQYVTTYA 570 >>CCDS2847.1 ALAS1 gene_id:211|Hs109|chr3 (640 aa) initn: 2338 init1: 2271 opt: 2334 Z-score: 2851.4 bits: 537.7 E(33420): 1.7e-152 Smith-Waterman score: 2394; 60.9% identity (82.3% similar) in 598 aa overlap (1-578:48-632) 10 20 30 pF1KE2 MVTAAMLLQCCPVLARGPTSLLGKVVKTHQ . :::. : . :.: :..:.. CCDS28 FLQKAGKSLLFYAQNCPKMMEVGAKPAPRALSTAAVHYQ--QIKETPPASEKDKTAKAK- 20 30 40 50 60 70 40 50 60 70 80 pF1KE2 FLFGIGRCPILATQGPNCSQIHLKATKAGGDSPSWAKG---HCPFMLSELQDGKSKIVQK . . : . :.:. .:. .: :. ..: .:::. ..... :.. : CCDS28 ----VQQTPDGSQQSPDGTQL-----PSGHPLPATSQGTASKCPFLAAQMNQRGSSVFCK 80 90 100 110 120 90 100 110 120 130 pF1KE2 AAPEVQEDVKAF--------KTDLPSSLVSVS--------LRKPFSGPQEQEQISGKVTH :. :.::::. . .:. :.:::. : : :. . :.: .:.: CCDS28 ASLELQEDVQEMNAVRKEVAETSAGPSVVSVKTDGGDPSGLLKNFQDIM-QKQRPERVSH 130 140 150 160 170 180 140 150 160 170 180 190 pF1KE2 LIQNNMPGNY-VFSYDQFFRDKIMEKKQDHTYRVFKTVNRWADAYPFAQHFSEASVASKD :.:.:.: . .:.::.::. :: :::.:::::::::::: : .:.:. .:.. ...:. CCDS28 LLQDNLPKSVSTFQYDRFFEKKIDEKKNDHTYRVFKTVNRRAHIFPMADDYSDSLITKKQ 190 200 210 220 230 240 200 210 220 230 240 250 pF1KE2 VSVWCSNDYLGMSRHPQVLQATQETLQRHGAGAGGTRNISGTSKFHVELEQELAELHQKD ::::::::::::::::.: :...::..:::::::::::::::::::.::.:::.:: :: CCDS28 VSVWCSNDYLGMSRHPRVCGAVMDTLKQHGAGAGGTRNISGTSKFHVDLERELADLHGKD 250 260 270 280 290 300 260 270 280 290 300 310 pF1KE2 SALLFSSCFVANDSTLFTLAKILPGCEIYSDAGNHASMIQGIRNSGAAKFVFRHNDPDHL .::::::::::::::::::::..::::::::.::::::::::::: . :..::::: .:: CCDS28 AALLFSSCFVANDSTLFTLAKMMPGCEIYSDSGNHASMIQGIRNSRVPKYIFRHNDVSHL 310 320 330 340 350 360 320 330 340 350 360 370 pF1KE2 KKLLEKSNPKIPKIVAFETVHSMDGAICPLEELCDVSHQYGALTFVDEVHAVGLYGSRGA ..::..:.:..:::::::::::::::.:::::::::.:..::.:::::::::::::.::. CCDS28 RELLQRSDPSVPKIVAFETVHSMDGAVCPLEELCDVAHEFGAITFVDEVHAVGLYGARGG 370 380 390 400 410 420 380 390 400 410 420 430 pF1KE2 GIGERDGIMHKIDIISGTLGKAFGCVGGYIASTRDLVDMVRSYAAGFIFTTSLPPMVLSG :::.:::.: :.::::::::::::::::::::: .:.: :::::::::::::::::.:.: CCDS28 GIGDRDGVMPKMDIISGTLGKAFGCVGGYIASTSSLIDTVRSYAAGFIFTTSLPPMLLAG 430 440 450 460 470 480 440 450 460 470 480 490 pF1KE2 ALESVRLLKGEEGQALRRAHQRNVKHMRQLLMDRGLPVIPCPSHIIPIRVGNAALNSKLC ::::::.::. ::..::: :::::: :::.::: ::::. :::::::.::..:: :...: CCDS28 ALESVRILKSAEGRVLRRQHQRNVKLMRQMLMDAGLPVVHCPSHIIPVRVADAAKNTEVC 490 500 510 520 530 540 500 510 520 530 540 550 pF1KE2 DLLLSKHGIYVQAINYPTVPRGEELLRLAPSPHHSPQMMEDFVEKLLLAWTAVGLPLQDV : :.:.:.:::::::::::::::::::.::.:::.::::. :.:.::..: ::: :. CCDS28 DELMSRHNIYVQAINYPTVPRGEELLRIAPTPHHTPQMMNYFLENLLVTWKQVGLELKPH 550 560 570 580 590 600 560 570 580 pF1KE2 SVAACNFCRRPVHFELMSEWERSYFGNMGPQYVTTYA : : :::::::.:::.::: :.:::... CCDS28 SSAECNFCRRPLHFEVMSEREKSYFSGLSKLVSAQA 610 620 630 640 >>CCDS13957.1 GCAT gene_id:23464|Hs109|chr22 (419 aa) initn: 719 init1: 329 opt: 767 Z-score: 936.5 bits: 182.8 E(33420): 7.8e-46 Smith-Waterman score: 767; 37.4% identity (69.6% similar) in 345 aa overlap (194-537:70-409) 170 180 190 200 210 220 pF1KE2 VFKTVNRWADAYPFAQHFSEASVASKDVSVWCSNDYLGMSRHPQVLQATQETLQRHGAGA .:.:.:::.: ::.:.:: ..:.. ::: CCDS13 GAGTWKSERVITSRQGPHIRVDGVSGGILNFCANNYLGLSSHPEVIQAGLQALEEFGAGL 40 50 60 70 80 90 230 240 250 260 270 280 pF1KE2 GGTRNISGTSKFHVELEQELAELHQKDSALLFSSCFVANDSTLFTLAKILPGCEIYSDAG ...: : ::...: .:: ..:..::...:.:. ::. :: . :: : . : . :: CCDS13 SSVRFICGTQSIHKNLEAKIARFHQREDAILYPSCYDAN-AGLFE-ALLTPEDAVLSDEL 100 110 120 130 140 150 290 300 310 320 330 340 pF1KE2 NHASMIQGIRNSGAAKFVFRHNDPDHLKKLLEKSNPKIPKIVAFETVHSMDGAICPLEEL ::::.:.::: : :. .:: : :. :.... . ..:: . . :::: : ::.:. CCDS13 NHASIIDGIRLCKAHKYRYRHLDMADLEAKLQEAQKHRLRLVATDGAFSMDGDIAPLQEI 160 170 180 190 200 210 350 360 370 380 390 400 pF1KE2 CDVSHQYGALTFVDEVHAVGLYGSRGAGIGERDGIMHKIDIISGTLGKAFGCV-GGYIAS : .. .::::.:.:: ::.:. : : : : :.: .. ::..:::::.: . ::: .. CCDS13 CCLASRYGALVFMDECHATGFLGPTGRGTDELLGVMDQVTIINSTLGKALGGASGGYTTG 220 230 240 250 260 270 410 420 430 440 450 460 pF1KE2 TRDLVDMVRSYAAGFIFTTSLPPMVLSGALESVRLLKGEEGQALRRAHQRNVKHMRQLLM ::...:. : ..:..:::: :.. : ... :: : .... .. .....:. . CCDS13 PGPLVSLLRQRARPYLFSNSLPPAVVGCASKALDLLMG--SNTIVQSMAAKTQRFRSKME 280 290 300 310 320 330 470 480 490 500 510 520 pF1KE2 DRGLPVIPCPSHIIPIRVGNAALNSKLCDLLLSKHGIYVQAINYPTVPRGEELLRLAPSP :. . : :. .:.: : :.. : .: :.::.: ...::.::.:. .:. : CCDS13 AAGFTISGASHPICPVMLGDARLASRMADDML-KRGIFVIGFSYPVVPKGKARIRVQISA 340 350 360 370 380 390 530 540 550 560 570 580 pF1KE2 HHSPQMMEDFVEKLLLAWTAVGLPLQDVSVAACNFCRRPVHFELMSEWERSYFGNMGPQY :: . .. :: .. CCDS13 VHSEEDIDRCVEAFVEVGRLHGALP 400 410 >>CCDS54527.1 GCAT gene_id:23464|Hs109|chr22 (445 aa) initn: 719 init1: 329 opt: 767 Z-score: 936.1 bits: 182.8 E(33420): 8.2e-46 Smith-Waterman score: 767; 37.4% identity (69.6% similar) in 345 aa overlap (194-537:96-435) 170 180 190 200 210 220 pF1KE2 VFKTVNRWADAYPFAQHFSEASVASKDVSVWCSNDYLGMSRHPQVLQATQETLQRHGAGA .:.:.:::.: ::.:.:: ..:.. ::: CCDS54 GPGTVIFPGLPLPHLSCCIHLLSFTSGILNFCANNYLGLSSHPEVIQAGLQALEEFGAGL 70 80 90 100 110 120 230 240 250 260 270 280 pF1KE2 GGTRNISGTSKFHVELEQELAELHQKDSALLFSSCFVANDSTLFTLAKILPGCEIYSDAG ...: : ::...: .:: ..:..::...:.:. ::. :: . :: : . : . :: CCDS54 SSVRFICGTQSIHKNLEAKIARFHQREDAILYPSCYDAN-AGLFE-ALLTPEDAVLSDEL 130 140 150 160 170 180 290 300 310 320 330 340 pF1KE2 NHASMIQGIRNSGAAKFVFRHNDPDHLKKLLEKSNPKIPKIVAFETVHSMDGAICPLEEL ::::.:.::: : :. .:: : :. :.... . ..:: . . :::: : ::.:. CCDS54 NHASIIDGIRLCKAHKYRYRHLDMADLEAKLQEAQKHRLRLVATDGAFSMDGDIAPLQEI 190 200 210 220 230 240 350 360 370 380 390 400 pF1KE2 CDVSHQYGALTFVDEVHAVGLYGSRGAGIGERDGIMHKIDIISGTLGKAFGCV-GGYIAS : .. .::::.:.:: ::.:. : : : : :.: .. ::..:::::.: . ::: .. CCDS54 CCLASRYGALVFMDECHATGFLGPTGRGTDELLGVMDQVTIINSTLGKALGGASGGYTTG 250 260 270 280 290 300 410 420 430 440 450 460 pF1KE2 TRDLVDMVRSYAAGFIFTTSLPPMVLSGALESVRLLKGEEGQALRRAHQRNVKHMRQLLM ::...:. : ..:..:::: :.. : ... :: : .... .. .....:. . CCDS54 PGPLVSLLRQRARPYLFSNSLPPAVVGCASKALDLLMG--SNTIVQSMAAKTQRFRSKME 310 320 330 340 350 360 470 480 490 500 510 520 pF1KE2 DRGLPVIPCPSHIIPIRVGNAALNSKLCDLLLSKHGIYVQAINYPTVPRGEELLRLAPSP :. . : :. .:.: : :.. : .: :.::.: ...::.::.:. .:. : CCDS54 AAGFTISGASHPICPVMLGDARLASRMADDML-KRGIFVIGFSYPVVPKGKARIRVQISA 370 380 390 400 410 420 530 540 550 560 570 580 pF1KE2 HHSPQMMEDFVEKLLLAWTAVGLPLQDVSVAACNFCRRPVHFELMSEWERSYFGNMGPQY :: . .. :: .. CCDS54 VHSEEDIDRCVEAFVEVGRLHGALP 430 440 >>CCDS13115.2 SPTLC3 gene_id:55304|Hs109|chr20 (552 aa) initn: 360 init1: 178 opt: 437 Z-score: 530.7 bits: 108.1 E(33420): 3.1e-23 Smith-Waterman score: 613; 28.2% identity (64.0% similar) in 419 aa overlap (145-536:110-520) 120 130 140 150 160 pF1KE2 PFSGPQEQEQISGKVTHLIQNNMPGNYVFSYDQFFRDKIMEKKQDHTYR--------VFK ...:. ... . .:. : .: CCDS13 RDFLRNWGIEKCNAAVERKEQKDFVPLYQDFENFYTRNLYMRIRDNWNRPICSAPGPLFD 80 90 100 110 120 130 170 180 190 200 210 220 pF1KE2 TVNRWADAYPFAQHFSEASVASKDVSVWCSNDYLGMS-RHPQVLQATQETLQRHGAGAGG ..: .: : .. .:. . ::: : ..::.. .. . ... ...:. .:.:... CCDS13 LMERVSDDYNWTFRFTGRVI--KDVINMGSYNFLGLAAKYDESMRTIKDVLEVYGTGVAS 140 150 160 170 180 190 230 240 250 260 270 280 pF1KE2 TRNISGTSKFHVELEQELAELHQKDSALLFSSCFVANDSTLFTLAKILPGCEIYSDAGNH ::. :: : :::. .:.. . ..:..:. :..:. .. .: . :: : :: :: CCDS13 TRHEMGTLDKHKELEDLVAKFLNVEAAMVFGMGFATNSMNIPAL--VGKGCLILSDELNH 200 210 220 230 240 250 290 300 310 320 330 pF1KE2 ASMIQGIRNSGAAKFVFRHNDPDHLKKLLEKS----NPKIPK-----IVAFETVHSMDGA .:.. : : :::. .:.::. . :.:::. . .:. . .. : :.::.:. CCDS13 TSLVLGARLSGATIRIFKHNNTQSLEKLLRDAVIYGQPRTRRAWKKILILVEGVYSMEGS 260 270 280 290 300 310 340 350 360 370 380 390 pF1KE2 ICPLEELCDVSHQYGALTFVDEVHAVGLYGSRGAGIGERDGI-MHKIDIISGTLGKAFGC : : .. ....: : ..::.:..: : : :. : :. :..:.. ::. :.:: CCDS13 IVHLPQIIALKKKYKAYLYIDEAHSIGAVGPTGRGVTEFFGLDPHEVDVLMGTFTKSFGA 320 330 340 350 360 370 400 410 420 430 440 450 pF1KE2 VGGYIASTRDLVDMVRSYAAGFIFTTSLPPMVLSGALESVRLLKGEEG--QALRRAHQ-- :::::. .::::..: .. . ....:. : . ..:..:. : .: :.:.:..: CCDS13 SGGYIAGRKDLVDYLRVHSHSAVYASSMSPPIAEQIIRSLKLIMGLDGTTQGLQRVQQLA 380 390 400 410 420 430 460 470 480 490 500 pF1KE2 RNVKHMRQLLMDRGLPVIPCPS-HIIPIRV---GNAALNSKLCDLLLSKHGIYVQAINYP .:....:: :.. :. . . ..:. . :..: .. .: .: :. : ...: CCDS13 KNTRYFRQRLQEMGFIIYGNENASVVPLLLYMPGKVAAFAR--HMLEKKIGVVV--VGFP 440 450 460 470 480 490 510 520 530 540 550 560 pF1KE2 TVPRGEELLRLAPSPHHSPQMMEDFVEKLLLAWTAVGLPLQDVSVAACNFCRRPVHFELM ..: .: :. : :. .:.. .: : CCDS13 ATPLAEARARFCVSAAHTREMLDTVLEALDEMGDLLQLKYSRHKKSARPELYDETSFELE 500 510 520 530 540 550 >>CCDS9865.1 SPTLC2 gene_id:9517|Hs109|chr14 (562 aa) initn: 316 init1: 154 opt: 360 Z-score: 436.4 bits: 90.7 E(33420): 5.6e-18 Smith-Waterman score: 534; 28.0% identity (62.8% similar) in 379 aa overlap (174-536:153-528) 150 160 170 180 190 200 pF1KE2 SYDQFFRDKIMEKKQDHTYRVFKTVNRWADAYPFAQHFSEASVASKDVSVWCSNDYLGMS .. . :. .. : : : .:::.. CCDS98 TRNLYMRIRDNWNRPICSVPGARVDIMERQSHDYNWSFKYTGNIIKGVINMGSYNYLGFA 130 140 150 160 170 180 210 220 230 240 250 260 pF1KE2 RHPQVLQ-ATQETLQRHGAGAGGTRNISGTSKFHVELEQELAELHQKDSALLFSSCFVAN :. : :. ..:...:::. .::. :. : :::. .:.. ..:. .. :..: CCDS98 RNTGSCQEAAAKVLEEYGAGVCSTRQEIGNLDKHEELEELVARFLGVEAAMAYGMGFATN 190 200 210 220 230 240 270 280 290 300 310 pF1KE2 DSTLFTLAKILPGCEIYSDAGNHASMIQGIRNSGAAKFVFRHNDPDHLKKLLEKS----N . .. .: . :: : :: ::::.. : : :::. .:.::. . :.:::. . . CCDS98 SMNIPAL--VGKGCLILSDELNHASLVLGARLSGATIRIFKHNNMQSLEKLLKDAIVYGQ 250 260 270 280 290 300 320 330 340 350 360 370 pF1KE2 PKIPK-----IVAFETVHSMDGAICPLEELCDVSHQYGALTFVDEVHAVGLYGSRGAGIG :. . .. : ..::.:.: : :. ....: : ..::.:..: : : :. CCDS98 PRTRRPWKKILILVEGIYSMEGSIVRLPEVIALKKKYKAYLYLDEAHSIGALGPTGRGVV 310 320 330 340 350 360 380 390 400 410 420 430 pF1KE2 ERDGI-MHKIDIISGTLGKAFGCVGGYIASTRDLVDMVRSYAAGFIFTTSLPPMVLSGAL : :. . .:.. ::. :.:: ::::.. ..:.:..:... . ...::: : :. . CCDS98 EYFGLDPEDVDVMMGTFTKSFGASGGYIGGKKELIDYLRTHSHSAVYATSLSPPVVEQII 370 380 390 400 410 420 440 450 460 470 480 pF1KE2 ESVRLLKGEEGQALRR--AHQ--RNVKHMRQLLMDRGLPVIPCP-SHIIPIRVGNAALNS :.. . :..: .: . ..: .:....:. : . :. . : ..:. . : . CCDS98 TSMKCIMGQDGTSLGKECVQQLAENTRYFRRRLKEMGFIIYGNEDSPVVPLMLYMPAKIG 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE2 KLCDLLLSKHGIYVQAINYPTVPRGEELLRLAPSPHHSPQMMEDFVEKLLLAWTAVGLPL . .: :..: : ....:..: : :. : :. .... .... CCDS98 AFGREML-KRNIGVVVVGFPATPIIESRARFCLSAAHTKEILDTALKEIDEVGDLLQLKY 490 500 510 520 530 550 560 570 580 pF1KE2 QDVSVAACNFCRRPVHFELMSEWERSYFGNMGPQYVTTYA CCDS98 SRHRLVPLLDRPFDETTYEETED 540 550 560 >>CCDS6692.1 SPTLC1 gene_id:10558|Hs109|chr9 (473 aa) initn: 312 init1: 131 opt: 255 Z-score: 309.1 bits: 66.9 E(33420): 7e-11 Smith-Waterman score: 422; 27.9% identity (63.9% similar) in 269 aa overlap (186-443:95-361) 160 170 180 190 200 210 pF1KE2 KKQDHTYRVFKTVNRWADAYPFAQHFSEASVASKDVSVWCSNDYLGMSRHPQVLQATQET : .:. . : ..::. .:.: :. . CCDS66 QPEPLVPPVPKDHPALNYNIVSGPPSHKTVVNGKECINFASFNFLGLLDNPRVKAAALAS 70 80 90 100 110 120 220 230 240 250 260 270 pF1KE2 LQRHGAGAGGTRNISGTSKFHVELEQELAELHQKDSALLFSSCFVANDSTLFTLAKILPG :...:.:. : :.. :: :..::..::.. . . :...: :.. :.. . .: : CCDS66 LKKYGVGTCGPRGFYGTFDVHLDLEDRLAKFMKTEEAIIYSYGFATIASAIPAYSK--RG 130 140 150 160 170 180 280 290 300 310 320 pF1KE2 CEIYSDAGNHASMIQGIRNSGAAKFVFRHNDPDHLKKLL------EKSNPKIPKI----V .. : . .. .:.. : . .:.::: :..:: ...::. .. . CCDS66 DIVFVDRAACFAIQKGLQASRSDIKLFKHNDMADLERLLKEQEIEDQKNPRKARVTRRFI 190 200 210 220 230 240 330 340 350 360 370 380 pF1KE2 AFETVHSMDGAICPLEELCDVSHQYGALTFVDEVHAVGLYGSRGAGIGERDGI-MHKIDI . : .. :.:::: :: ....: : :..: . :. : .: :. :. :: . ::. CCDS66 VVEGLYMNTGTICPLPELVKLKYKYKARIFLEESLSFGVLGEHGRGVTEHYGINIDDIDL 250 260 270 280 290 300 390 400 410 420 430 440 pF1KE2 ISGTLGKAFGCVGGYIASTRDLVDMVRSYAAGFIFTTSLPPMVLSGALESVRLLKGEEGQ ::... .:.. .::. . ..: : . :. :..::::.. ..:.:.. ... . : CCDS66 ISANMENALASIGGFCCGRSFVIDHQRLSGQGYCFSASLPPLLAAAAIEALNIMEENPGI 310 320 330 340 350 360 450 460 470 480 490 500 pF1KE2 ALRRAHQRNVKHMRQLLMDRGLPVIPCPSHIIPIRVGNAALNSKLCDLLLSKHGIYVQAI CCDS66 FAVLKEKCGQIHKALQGISGLKVVGESLSPAFHLQLEESTGSREQDVRLLQEIVDQCMNR 370 380 390 400 410 420 587 residues in 1 query sequences 18921897 residues in 33420 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Apr 23 11:12:52 2019 done: Tue Apr 23 11:12:52 2019 Total Scan time: 1.490 Total Display time: 0.090 Function used was FASTA [36.3.4 Apr, 2011]