Result of FASTA (omim) for
pFN21AE4058
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE4058, 323 aa
1>>>pF1KE4058 323 - 323 aa - 323 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.7742+/-0.000566; mu= 13.7405+/- 0.034
mean_var=185.9536+/-40.811, 0's: 0 Z-trim(113.0): 599 B-trim: 928 in 1/53
Lambda= 0.094053
statistics sampled from 21378 (22148) to 21378 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.64), E-opt: 0.2 (0.26), width: 16
Scan time: 7.860
The best scores are: opt bits E(85289)
NP_543149 (OMIM: 300626) ankyrin repeat and SOCS b ( 323) 2159 306.0 6.8e-83
NP_001012428 (OMIM: 300626) ankyrin repeat and SOC ( 302) 1771 253.3 4.6e-67
NP_001188512 (OMIM: 300626) ankyrin repeat and SOC ( 306) 1492 215.5 1.2e-55
NP_543150 (OMIM: 615050) ankyrin repeat and SOCS b ( 329) 1183 173.6 5e-43
XP_005262816 (OMIM: 615050) PREDICTED: ankyrin rep ( 329) 1183 173.6 5e-43
XP_011529919 (OMIM: 615050) PREDICTED: ankyrin rep ( 276) 1005 149.3 8.5e-36
XP_011529918 (OMIM: 615050) PREDICTED: ankyrin rep ( 284) 1002 148.9 1.1e-35
XP_005274503 (OMIM: 300890) PREDICTED: ankyrin rep ( 294) 978 145.7 1.1e-34
NP_001026909 (OMIM: 300890) ankyrin repeat and SOC ( 294) 978 145.7 1.1e-34
XP_016884772 (OMIM: 300890) PREDICTED: ankyrin rep ( 377) 976 145.6 1.5e-34
NP_001162003 (OMIM: 300890) ankyrin repeat and SOC ( 262) 823 124.6 2.3e-28
NP_076992 (OMIM: 300890) ankyrin repeat and SOCS b ( 262) 823 124.6 2.3e-28
XP_016884775 (OMIM: 300890) PREDICTED: ankyrin rep ( 345) 821 124.5 3.2e-28
XP_016884774 (OMIM: 300890) PREDICTED: ankyrin rep ( 345) 821 124.5 3.2e-28
XP_011543760 (OMIM: 300890) PREDICTED: ankyrin rep ( 265) 721 110.8 3.3e-24
XP_016884773 (OMIM: 300890) PREDICTED: ankyrin rep ( 348) 722 111.1 3.5e-24
NP_078977 (OMIM: 615055) ankyrin repeat and SOCS b ( 278) 674 104.4 2.8e-22
XP_011543762 (OMIM: 300890) PREDICTED: ankyrin rep ( 233) 566 89.6 6.6e-18
NP_001162002 (OMIM: 300890) ankyrin repeat and SOC ( 252) 455 74.6 2.4e-13
NP_065210 (OMIM: 182900,612641) ankyrin-1 isoform (1719) 356 62.5 7.4e-09
XP_011542805 (OMIM: 182900,612641) PREDICTED: anky (1791) 356 62.5 7.6e-09
XP_016868817 (OMIM: 182900,612641) PREDICTED: anky (1792) 356 62.5 7.6e-09
XP_016868816 (OMIM: 182900,612641) PREDICTED: anky (1807) 356 62.5 7.6e-09
NP_065208 (OMIM: 182900,612641) ankyrin-1 isoform (1856) 356 62.5 7.8e-09
NP_000028 (OMIM: 182900,612641) ankyrin-1 isoform (1880) 356 62.5 7.8e-09
NP_065209 (OMIM: 182900,612641) ankyrin-1 isoform (1881) 356 62.5 7.8e-09
XP_016868815 (OMIM: 182900,612641) PREDICTED: anky (1892) 356 62.5 7.8e-09
XP_016868814 (OMIM: 182900,612641) PREDICTED: anky (1908) 356 62.5 7.9e-09
XP_016868812 (OMIM: 182900,612641) PREDICTED: anky (1936) 356 62.5 7.9e-09
XP_011542798 (OMIM: 182900,612641) PREDICTED: anky (1944) 356 62.5 8e-09
XP_016868809 (OMIM: 182900,612641) PREDICTED: anky (1946) 356 62.5 8e-09
XP_011542797 (OMIM: 182900,612641) PREDICTED: anky (1953) 356 62.5 8e-09
XP_011542796 (OMIM: 182900,612641) PREDICTED: anky (1954) 356 62.5 8e-09
XP_016868808 (OMIM: 182900,612641) PREDICTED: anky (1961) 356 62.6 8e-09
XP_011542793 (OMIM: 182900,612641) PREDICTED: anky (1968) 356 62.6 8e-09
XP_011542792 (OMIM: 182900,612641) PREDICTED: anky (1969) 356 62.6 8e-09
XP_016863506 (OMIM: 615929) PREDICTED: ankyrin rep (1116) 339 59.9 2.9e-08
XP_016863505 (OMIM: 615929) PREDICTED: ankyrin rep (1229) 339 59.9 3.1e-08
XP_016863504 (OMIM: 615929) PREDICTED: ankyrin rep (1367) 339 60.0 3.2e-08
XP_016863503 (OMIM: 615929) PREDICTED: ankyrin rep (1479) 339 60.1 3.4e-08
XP_005265730 (OMIM: 615929) PREDICTED: ankyrin rep (1480) 339 60.1 3.4e-08
XP_005265729 (OMIM: 615929) PREDICTED: ankyrin rep (1543) 339 60.1 3.5e-08
NP_001183959 (OMIM: 610500) ankyrin repeat and KH ( 581) 333 58.6 3.6e-08
NP_060448 (OMIM: 610500) ankyrin repeat and KH dom ( 616) 333 58.7 3.7e-08
NP_078944 (OMIM: 610500) ankyrin repeat and KH dom ( 627) 333 58.7 3.7e-08
XP_016863502 (OMIM: 615929) PREDICTED: ankyrin rep (2238) 339 60.3 4.2e-08
XP_016863501 (OMIM: 615929) PREDICTED: ankyrin rep (2239) 339 60.3 4.2e-08
XP_016861517 (OMIM: 611122) PREDICTED: serine/thre ( 687) 332 58.6 4.3e-08
XP_005265728 (OMIM: 615929) PREDICTED: ankyrin rep (2351) 339 60.4 4.4e-08
NP_942592 (OMIM: 615929) ankyrin repeat domain-con (2352) 339 60.4 4.4e-08
>>NP_543149 (OMIM: 300626) ankyrin repeat and SOCS box p (323 aa)
initn: 2159 init1: 2159 opt: 2159 Z-score: 1609.2 bits: 306.0 E(85289): 6.8e-83
Smith-Waterman score: 2159; 100.0% identity (100.0% similar) in 323 aa overlap (1-323:1-323)
10 20 30 40 50 60
pF1KE4 MEDGPVFYGFKNIFITMFATFFFFKLLIKVFLALLTHFYIVKGNRKEAARIAEEIYGGIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_543 MEDGPVFYGFKNIFITMFATFFFFKLLIKVFLALLTHFYIVKGNRKEAARIAEEIYGGIS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 DCWADRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_543 DCWADRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLEN
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 GAHVNGVTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLASPIHEAVKRGHRECME
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_543 GAHVNGVTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLASPIHEAVKRGHRECME
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 ILLANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLDTPLHAAARQSN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_543 ILLANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLDTPLHAAARQSN
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 VEVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLLREGPPALSQLCRLCVRKCLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_543 VEVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLLREGPPALSQLCRLCVRKCLG
250 260 270 280 290 300
310 320
pF1KE4 RACHQAIHKLHLPEPLERFLLYQ
:::::::::::::::::::::::
NP_543 RACHQAIHKLHLPEPLERFLLYQ
310 320
>>NP_001012428 (OMIM: 300626) ankyrin repeat and SOCS bo (302 aa)
initn: 1771 init1: 1771 opt: 1771 Z-score: 1325.0 bits: 253.3 E(85289): 4.6e-67
Smith-Waterman score: 1771; 100.0% identity (100.0% similar) in 263 aa overlap (61-323:40-302)
40 50 60 70 80 90
pF1KE4 FLALLTHFYIVKGNRKEAARIAEEIYGGISDCWADRSPLHEAAAQGRLLALKTLIAQGVN
::::::::::::::::::::::::::::::
NP_001 KNCEVSERIRRSGPWKEISFGDYICHTFQGDCWADRSPLHEAAAQGRLLALKTLIAQGVN
10 20 30 40 50 60
100 110 120 130 140 150
pF1KE4 VNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVL
70 80 90 100 110 120
160 170 180 190 200 210
pF1KE4 LEFGAKAQLEVHLASPIHEAVKRGHRECMEILLANNVNIDHEVPQLGTPLYVACTYQRVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LEFGAKAQLEVHLASPIHEAVKRGHRECMEILLANNVNIDHEVPQLGTPLYVACTYQRVD
130 140 150 160 170 180
220 230 240 250 260 270
pF1KE4 CVKKLLELGASVDHGQWLDTPLHAAARQSNVEVIHLLTDYGANLKRRNAQGKSALDLAAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CVKKLLELGASVDHGQWLDTPLHAAARQSNVEVIHLLTDYGANLKRRNAQGKSALDLAAP
190 200 210 220 230 240
280 290 300 310 320
pF1KE4 KSSVEQALLLREGPPALSQLCRLCVRKCLGRACHQAIHKLHLPEPLERFLLYQ
:::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KSSVEQALLLREGPPALSQLCRLCVRKCLGRACHQAIHKLHLPEPLERFLLYQ
250 260 270 280 290 300
>>NP_001188512 (OMIM: 300626) ankyrin repeat and SOCS bo (306 aa)
initn: 1489 init1: 1489 opt: 1492 Z-score: 1120.3 bits: 215.5 E(85289): 1.2e-55
Smith-Waterman score: 2013; 94.7% identity (94.7% similar) in 323 aa overlap (1-323:1-306)
10 20 30 40 50 60
pF1KE4 MEDGPVFYGFKNIFITMFATFFFFKLLIKVFLALLTHFYIVKGNRKEAARIAEEIYGGIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MEDGPVFYGFKNIFITMFATFFFFKLLIKVFLALLTHFYIVKGNRKEAARIAEEIYGGIS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 DCWADRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLEN
::::::::::::::::::::::::::: ::::::::::::::::
NP_001 DCWADRSPLHEAAAQGRLLALKTLIAQ-----------------ACLGGHVACAKALLEN
70 80 90 100
130 140 150 160 170 180
pF1KE4 GAHVNGVTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLASPIHEAVKRGHRECME
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GAHVNGVTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLASPIHEAVKRGHRECME
110 120 130 140 150 160
190 200 210 220 230 240
pF1KE4 ILLANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLDTPLHAAARQSN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ILLANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLDTPLHAAARQSN
170 180 190 200 210 220
250 260 270 280 290 300
pF1KE4 VEVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLLREGPPALSQLCRLCVRKCLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VEVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLLREGPPALSQLCRLCVRKCLG
230 240 250 260 270 280
310 320
pF1KE4 RACHQAIHKLHLPEPLERFLLYQ
:::::::::::::::::::::::
NP_001 RACHQAIHKLHLPEPLERFLLYQ
290 300
>>NP_543150 (OMIM: 615050) ankyrin repeat and SOCS box p (329 aa)
initn: 1522 init1: 902 opt: 1183 Z-score: 893.4 bits: 173.6 E(85289): 5e-43
Smith-Waterman score: 1183; 53.8% identity (81.8% similar) in 325 aa overlap (2-323:6-329)
10 20 30 40 50
pF1KE4 MEDGPVFYGFKNIFITMFATFFFFKLLIKVFLALLTHFYIVKGNRKEAARIAEEIY
:. : ..:...:.. ..: :::..:. ::.:.:::::::::::::::: :.:
NP_543 MSVLEENRPFAQQLSNVYFTIL-SLFCFKLFVKISLAILSHFYIVKGNRKEAARIAAEFY
10 20 30 40 50
60 70 80 90 100 110
pF1KE4 GGISD--CWADRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACA
: . :::::::::::.:::::::.::..:: ::: ::...:. ::::::: :::::
NP_543 GVTQGQGSWADRSPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACA
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE4 KALLENGAHVNGVTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLASPIHEAVKRG
..::: ::.::..:. :.::::::: .:: .:...:::.::::::: : :: :::...:
NP_543 RTLLEAGANVNAITIDGVTPLFNACSQGSPSCAELLLEYGAKAQLESCLPSPTHEAASKG
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE4 HRECMEILLANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLDTPLHA
:.::..::.. ....:.:.:.::::::::: :. :. ::: ::.:..:.. ::::::
NP_543 HHECLDILISWGIDVDQEIPHLGTPLYVACMSQQFHCIWKLLYAGADVQKGKYWDTPLHA
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE4 AARQSNVEVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLLREGPPA-LSQLCRL
::.::..:...:: ..::... .:.. .:.:. .: ::. :: .:. :. : :::::
NP_543 AAQQSSTEIVNLLLEFGADINAKNTELLRPIDVATSSSMVERILLQHEATPSSLYQLCRL
240 250 260 270 280 290
300 310 320
pF1KE4 CVRKCLGRACHQAIHKLHLPEPLERFLLYQ
:.:. .:. . : .:.:: :. :: :.
NP_543 CIRSYIGKPRLHLIPQLQLPTLLKNFLQYR
300 310 320
>>XP_005262816 (OMIM: 615050) PREDICTED: ankyrin repeat (329 aa)
initn: 1522 init1: 902 opt: 1183 Z-score: 893.4 bits: 173.6 E(85289): 5e-43
Smith-Waterman score: 1183; 53.8% identity (81.8% similar) in 325 aa overlap (2-323:6-329)
10 20 30 40 50
pF1KE4 MEDGPVFYGFKNIFITMFATFFFFKLLIKVFLALLTHFYIVKGNRKEAARIAEEIY
:. : ..:...:.. ..: :::..:. ::.:.:::::::::::::::: :.:
XP_005 MSVLEENRPFAQQLSNVYFTIL-SLFCFKLFVKISLAILSHFYIVKGNRKEAARIAAEFY
10 20 30 40 50
60 70 80 90 100 110
pF1KE4 GGISD--CWADRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACA
: . :::::::::::.:::::::.::..:: ::: ::...:. ::::::: :::::
XP_005 GVTQGQGSWADRSPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACA
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE4 KALLENGAHVNGVTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLASPIHEAVKRG
..::: ::.::..:. :.::::::: .:: .:...:::.::::::: : :: :::...:
XP_005 RTLLEAGANVNAITIDGVTPLFNACSQGSPSCAELLLEYGAKAQLESCLPSPTHEAASKG
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE4 HRECMEILLANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLDTPLHA
:.::..::.. ....:.:.:.::::::::: :. :. ::: ::.:..:.. ::::::
XP_005 HHECLDILISWGIDVDQEIPHLGTPLYVACMSQQFHCIWKLLYAGADVQKGKYWDTPLHA
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE4 AARQSNVEVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLLREGPPA-LSQLCRL
::.::..:...:: ..::... .:.. .:.:. .: ::. :: .:. :. : :::::
XP_005 AAQQSSTEIVNLLLEFGADINAKNTELLRPIDVATSSSMVERILLQHEATPSSLYQLCRL
240 250 260 270 280 290
300 310 320
pF1KE4 CVRKCLGRACHQAIHKLHLPEPLERFLLYQ
:.:. .:. . : .:.:: :. :: :.
XP_005 CIRSYIGKPRLHLIPQLQLPTLLKNFLQYR
300 310 320
>>XP_011529919 (OMIM: 615050) PREDICTED: ankyrin repeat (276 aa)
initn: 1353 init1: 902 opt: 1005 Z-score: 763.6 bits: 149.3 E(85289): 8.5e-36
Smith-Waterman score: 1005; 54.1% identity (82.7% similar) in 266 aa overlap (59-323:11-276)
30 40 50 60 70 80
pF1KE4 KVFLALLTHFYIVKGNRKEAARIAEEIYGGISDCWADRSPLHEAAAQGRLLALKTLIAQG
.. :::::::::::.:::::::.::..::
XP_011 MPLCNGGNLAVTGSWADRSPLHEAASQGRLLALRTLLSQG
10 20 30 40
90 100 110 120 130 140
pF1KE4 VNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVN
::: ::...:. ::::::: :::::..::: ::.::..:. :.::::::: .:: .:..
XP_011 YNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANVNAITIDGVTPLFNACSQGSPSCAE
50 60 70 80 90 100
150 160 170 180 190 200
pF1KE4 VLLEFGAKAQLEVHLASPIHEAVKRGHRECMEILLANNVNIDHEVPQLGTPLYVACTYQR
.:::.::::::: : :: :::...::.::..::.. ....:.:.:.::::::::: :.
XP_011 LLLEYGAKAQLESCLPSPTHEAASKGHHECLDILISWGIDVDQEIPHLGTPLYVACMSQQ
110 120 130 140 150 160
210 220 230 240 250 260
pF1KE4 VDCVKKLLELGASVDHGQWLDTPLHAAARQSNVEVIHLLTDYGANLKRRNAQGKSALDLA
:. ::: ::.:..:.. ::::::::.::..:...:: ..::... .:.. .:.:
XP_011 FHCIWKLLYAGADVQKGKYWDTPLHAAAQQSSTEIVNLLLEFGADINAKNTELLRPIDVA
170 180 190 200 210 220
270 280 290 300 310 320
pF1KE4 APKSSVEQALLLREGPPA-LSQLCRLCVRKCLGRACHQAIHKLHLPEPLERFLLYQ
. .: ::. :: .:. :. : ::::::.:. .:. . : .:.:: :. :: :.
XP_011 TSSSMVERILLQHEATPSSLYQLCRLCIRSYIGKPRLHLIPQLQLPTLLKNFLQYR
230 240 250 260 270
>>XP_011529918 (OMIM: 615050) PREDICTED: ankyrin repeat (284 aa)
initn: 1353 init1: 902 opt: 1002 Z-score: 761.3 bits: 148.9 E(85289): 1.1e-35
Smith-Waterman score: 1002; 53.8% identity (81.7% similar) in 273 aa overlap (54-323:12-284)
30 40 50 60 70 80
pF1KE4 FKLLIKVFLALLTHFYIVKGNRKEAARIAEEIYGGISD--CWADRSPLHEAAAQGRLLAL
:. : .: :::::::::::.:::::::
XP_011 MSRIYLDSGWCEVPWGDGDLGSWADRSPLHEAASQGRLLAL
10 20 30 40
90 100 110 120 130 140
pF1KE4 KTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCS
.::..:: ::: ::...:. ::::::: :::::..::: ::.::..:. :.::::::: .
XP_011 RTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANVNAITIDGVTPLFNACSQ
50 60 70 80 90 100
150 160 170 180 190 200
pF1KE4 GSAACVNVLLEFGAKAQLEVHLASPIHEAVKRGHRECMEILLANNVNIDHEVPQLGTPLY
:: .:...:::.::::::: : :: :::...::.::..::.. ....:.:.:.::::::
XP_011 GSPSCAELLLEYGAKAQLESCLPSPTHEAASKGHHECLDILISWGIDVDQEIPHLGTPLY
110 120 130 140 150 160
210 220 230 240 250 260
pF1KE4 VACTYQRVDCVKKLLELGASVDHGQWLDTPLHAAARQSNVEVIHLLTDYGANLKRRNAQG
::: :. :. ::: ::.:..:.. ::::::::.::..:...:: ..::... .:..
XP_011 VACMSQQFHCIWKLLYAGADVQKGKYWDTPLHAAAQQSSTEIVNLLLEFGADINAKNTEL
170 180 190 200 210 220
270 280 290 300 310 320
pF1KE4 KSALDLAAPKSSVEQALLLREGPPA-LSQLCRLCVRKCLGRACHQAIHKLHLPEPLERFL
.:.:. .: ::. :: .:. :. : ::::::.:. .:. . : .:.:: :. ::
XP_011 LRPIDVATSSSMVERILLQHEATPSSLYQLCRLCIRSYIGKPRLHLIPQLQLPTLLKNFL
230 240 250 260 270 280
pF1KE4 LYQ
:.
XP_011 QYR
>>XP_005274503 (OMIM: 300890) PREDICTED: ankyrin repeat (294 aa)
initn: 1191 init1: 966 opt: 978 Z-score: 743.6 bits: 145.7 E(85289): 1.1e-34
Smith-Waterman score: 978; 55.3% identity (79.2% similar) in 264 aa overlap (59-322:30-293)
30 40 50 60 70 80
pF1KE4 KVFLALLTHFYIVKGNRKEAARIAEEIYGGISDCWADRSPLHEAAAQGRLLALKTLIAQG
..: .: ::.:::: .:. :.:..::.::
XP_005 MDGKQGGMDGSKPAGPRDFPGIRLLSNPLMGDAVSDWSPMHEAAIHGHQLSLRNLISQG
10 20 30 40 50
90 100 110 120 130 140
pF1KE4 VNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVN
::..: ..:: :::::::::..:.: ::..::.:::::. ::::::: ::: :::
XP_005 WAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQVNGVTADWHTPLFNACVSGSWDCVN
60 70 80 90 100 110
150 160 170 180 190 200
pF1KE4 VLLEFGAKAQLEVHLASPIHEAVKRGHRECMEILLANNVNIDHEVPQLGTPLYVACTYQR
.::. ::..: : ::::::::..::: ::.. :.: . ::::.. .::::::.:: :.
XP_005 LLLQHGASVQPESDLASPIHEAARRGHVECVNSLIAYGGNIDHKISHLGTPLYLACENQQ
120 130 140 150 160 170
210 220 230 240 250 260
pF1KE4 VDCVKKLLELGASVDHGQWLDTPLHAAARQSNVEVIHLLTDYGANLKRRNAQGKSALDLA
::::::: ::.:..:. :.::::.:: .. :. :: :.::. . .::.:: ..:.
XP_005 RACVKKLLESGADVNQGKGQDSPLHAVARTASEELACLLMDFGADTQAKNAEGKRPVELV
180 190 200 210 220 230
270 280 290 300 310 320
pF1KE4 APKSSVEQALLLREGPPALSQLCRLCVRKCLGRACHQAIHKLHLPEPLERFLLYQ
:.: . : .: :::::.: ::::: .:::.: :. : :: ::: :..:::.
XP_005 PPESPLAQLFLEREGPPSLMQLCRLRIRKCFGIQQHHKITKLVLPEDLKQFLLHL
240 250 260 270 280 290
>>NP_001026909 (OMIM: 300890) ankyrin repeat and SOCS bo (294 aa)
initn: 1191 init1: 966 opt: 978 Z-score: 743.6 bits: 145.7 E(85289): 1.1e-34
Smith-Waterman score: 978; 55.3% identity (79.2% similar) in 264 aa overlap (59-322:30-293)
30 40 50 60 70 80
pF1KE4 KVFLALLTHFYIVKGNRKEAARIAEEIYGGISDCWADRSPLHEAAAQGRLLALKTLIAQG
..: .: ::.:::: .:. :.:..::.::
NP_001 MDGKQGGMDGSKPAGPRDFPGIRLLSNPLMGDAVSDWSPMHEAAIHGHQLSLRNLISQG
10 20 30 40 50
90 100 110 120 130 140
pF1KE4 VNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVN
::..: ..:: :::::::::..:.: ::..::.:::::. ::::::: ::: :::
NP_001 WAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQVNGVTADWHTPLFNACVSGSWDCVN
60 70 80 90 100 110
150 160 170 180 190 200
pF1KE4 VLLEFGAKAQLEVHLASPIHEAVKRGHRECMEILLANNVNIDHEVPQLGTPLYVACTYQR
.::. ::..: : ::::::::..::: ::.. :.: . ::::.. .::::::.:: :.
NP_001 LLLQHGASVQPESDLASPIHEAARRGHVECVNSLIAYGGNIDHKISHLGTPLYLACENQQ
120 130 140 150 160 170
210 220 230 240 250 260
pF1KE4 VDCVKKLLELGASVDHGQWLDTPLHAAARQSNVEVIHLLTDYGANLKRRNAQGKSALDLA
::::::: ::.:..:. :.::::.:: .. :. :: :.::. . .::.:: ..:.
NP_001 RACVKKLLESGADVNQGKGQDSPLHAVARTASEELACLLMDFGADTQAKNAEGKRPVELV
180 190 200 210 220 230
270 280 290 300 310 320
pF1KE4 APKSSVEQALLLREGPPALSQLCRLCVRKCLGRACHQAIHKLHLPEPLERFLLYQ
:.: . : .: :::::.: ::::: .:::.: :. : :: ::: :..:::.
NP_001 PPESPLAQLFLEREGPPSLMQLCRLRIRKCFGIQQHHKITKLVLPEDLKQFLLHL
240 250 260 270 280 290
>>XP_016884772 (OMIM: 300890) PREDICTED: ankyrin repeat (377 aa)
initn: 1191 init1: 966 opt: 976 Z-score: 741.0 bits: 145.6 E(85289): 1.5e-34
Smith-Waterman score: 976; 55.7% identity (79.0% similar) in 262 aa overlap (61-322:115-376)
40 50 60 70 80 90
pF1KE4 FLALLTHFYIVKGNRKEAARIAEEIYGGISDCWADRSPLHEAAAQGRLLALKTLIAQGVN
: .: ::.:::: .:. :.:..::.::
XP_016 SQFGKGRDISNFADLGLEGSCGLWRASSQLDAVSDWSPMHEAAIHGHQLSLRNLISQGWA
90 100 110 120 130 140
100 110 120 130 140 150
pF1KE4 VNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVL
::..: ..:: :::::::::..:.: ::..::.:::::. ::::::: ::: :::.:
XP_016 VNIITADHVSPLHEACLGGHLSCVKILLKHGAQVNGVTADWHTPLFNACVSGSWDCVNLL
150 160 170 180 190 200
160 170 180 190 200 210
pF1KE4 LEFGAKAQLEVHLASPIHEAVKRGHRECMEILLANNVNIDHEVPQLGTPLYVACTYQRVD
:. ::..: : ::::::::..::: ::.. :.: . ::::.. .::::::.:: :.
XP_016 LQHGASVQPESDLASPIHEAARRGHVECVNSLIAYGGNIDHKISHLGTPLYLACENQQRA
210 220 230 240 250 260
220 230 240 250 260 270
pF1KE4 CVKKLLELGASVDHGQWLDTPLHAAARQSNVEVIHLLTDYGANLKRRNAQGKSALDLAAP
::::::: ::.:..:. :.::::.:: .. :. :: :.::. . .::.:: ..:. :
XP_016 CVKKLLESGADVNQGKGQDSPLHAVARTASEELACLLMDFGADTQAKNAEGKRPVELVPP
270 280 290 300 310 320
280 290 300 310 320
pF1KE4 KSSVEQALLLREGPPALSQLCRLCVRKCLGRACHQAIHKLHLPEPLERFLLYQ
.: . : .: :::::.: ::::: .:::.: :. : :: ::: :..:::.
XP_016 ESPLAQLFLEREGPPSLMQLCRLRIRKCFGIQQHHKITKLVLPEDLKQFLLHL
330 340 350 360 370
323 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 03:25:14 2016 done: Sun Nov 6 03:25:15 2016
Total Scan time: 7.860 Total Display time: 0.030
Function used was FASTA [36.3.4 Apr, 2011]