FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE2083, 757 aa 1>>>pF1KE2083 757 - 757 aa - 757 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.8457+/-0.000388; mu= 13.7040+/- 0.024 mean_var=121.8492+/-24.317, 0's: 0 Z-trim(115.4): 40 B-trim: 0 in 0/51 Lambda= 0.116188 statistics sampled from 25812 (25852) to 25812 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.665), E-opt: 0.2 (0.303), width: 16 Scan time: 12.380 The best scores are: opt bits E(85289) XP_016884487 (OMIM: 614216) PREDICTED: activating ( 757) 5065 860.8 0 XP_016884488 (OMIM: 614216) PREDICTED: activating ( 757) 5065 860.8 0 XP_016884489 (OMIM: 614216) PREDICTED: activating ( 757) 5065 860.8 0 XP_005261832 (OMIM: 614216) PREDICTED: activating ( 757) 5065 860.8 0 NP_115580 (OMIM: 614216) activating signal cointeg ( 757) 5065 860.8 0 XP_016884481 (OMIM: 614216) PREDICTED: activating ( 811) 5065 860.8 0 XP_011528748 (OMIM: 614216) PREDICTED: activating ( 762) 5045 857.4 0 XP_016884485 (OMIM: 614216) PREDICTED: activating ( 762) 5045 857.4 0 XP_011528744 (OMIM: 614216) PREDICTED: activating ( 762) 5045 857.4 0 XP_011528746 (OMIM: 614216) PREDICTED: activating ( 762) 5045 857.4 0 XP_011528745 (OMIM: 614216) PREDICTED: activating ( 762) 5045 857.4 0 XP_011528747 (OMIM: 614216) PREDICTED: activating ( 762) 5045 857.4 0 XP_016884480 (OMIM: 614216) PREDICTED: activating ( 816) 5045 857.5 0 XP_016884492 (OMIM: 614216) PREDICTED: activating ( 704) 4499 765.9 0 XP_016884491 (OMIM: 614216) PREDICTED: activating ( 704) 4499 765.9 0 XP_016884490 (OMIM: 614216) PREDICTED: activating ( 704) 4499 765.9 0 XP_016884486 (OMIM: 614216) PREDICTED: activating ( 758) 4499 765.9 0 XP_011528751 (OMIM: 614216) PREDICTED: activating ( 709) 4479 762.5 0 XP_011528750 (OMIM: 614216) PREDICTED: activating ( 709) 4479 762.5 0 XP_016884484 (OMIM: 614216) PREDICTED: activating ( 763) 4479 762.6 0 XP_016884495 (OMIM: 614216) PREDICTED: activating ( 643) 4273 728.0 3e-209 XP_016884496 (OMIM: 614216) PREDICTED: activating ( 643) 4273 728.0 3e-209 XP_016884494 (OMIM: 614216) PREDICTED: activating ( 643) 4273 728.0 3e-209 XP_016884498 (OMIM: 614216) PREDICTED: activating ( 643) 4273 728.0 3e-209 XP_016884497 (OMIM: 614216) PREDICTED: activating ( 643) 4273 728.0 3e-209 XP_011528756 (OMIM: 614216) PREDICTED: activating ( 648) 4253 724.6 3e-208 XP_011528752 (OMIM: 614216) PREDICTED: activating ( 648) 4253 724.6 3e-208 XP_011528753 (OMIM: 614216) PREDICTED: activating ( 648) 4253 724.6 3e-208 XP_011528755 (OMIM: 614216) PREDICTED: activating ( 648) 4253 724.6 3e-208 XP_011528754 (OMIM: 614216) PREDICTED: activating ( 648) 4253 724.6 3e-208 XP_011528757 (OMIM: 614216) PREDICTED: activating ( 648) 4253 724.6 3e-208 NP_001229835 (OMIM: 614216) activating signal coin ( 681) 3972 677.6 4.8e-194 XP_016884493 (OMIM: 614216) PREDICTED: activating ( 679) 3006 515.6 2.6e-145 XP_016884483 (OMIM: 614216) PREDICTED: activating ( 786) 3006 515.7 3e-145 XP_016884482 (OMIM: 614216) PREDICTED: activating ( 791) 2986 512.3 3.1e-144 >>XP_016884487 (OMIM: 614216) PREDICTED: activating sign (757 aa) initn: 5065 init1: 5065 opt: 5065 Z-score: 4594.3 bits: 860.8 E(85289): 0 Smith-Waterman score: 5065; 100.0% identity (100.0% similar) in 757 aa overlap (1-757:1-757) 10 20 30 40 50 60 pF1KE2 MPALPLDQLQITHKDPKTGKLRTSPALHPEQKADRYFVLYKPPPKDNIPALVEEYLERAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MPALPLDQLQITHKDPKTGKLRTSPALHPEQKADRYFVLYKPPPKDNIPALVEEYLERAT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 FVANDLDWLLALPHDKFWCQVIFDETLQKCLDSYLRYVPRKFDEGVASAPEVVDMQKRLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FVANDLDWLLALPHDKFWCQVIFDETLQKCLDSYLRYVPRKFDEGVASAPEVVDMQKRLH 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 RSVFLTFLRMSTHKESKDHFISPSAFGEILYNNFLFDIPKILDLCVLFGKGNSPLLQKMI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RSVFLTFLRMSTHKESKDHFISPSAFGEILYNNFLFDIPKILDLCVLFGKGNSPLLQKMI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 GNIFTQQPSYYSDLDETLPTILQVFSNILQHCGLQGDGANTTPQKLEERGRLTPSDMPLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GNIFTQQPSYYSDLDETLPTILQVFSNILQHCGLQGDGANTTPQKLEERGRLTPSDMPLL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 ELKDIVLYLCDTCTTLWAFLDIFPLACQTFQKHDFCYRLASFYEAAIPEMESAIKKRRLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ELKDIVLYLCDTCTTLWAFLDIFPLACQTFQKHDFCYRLASFYEAAIPEMESAIKKRRLE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 DSKLLGDLWQRLSHSRKKLMEIFHIILNQICLLPILESSCDNIQGFIEEFLQIFSSLLQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DSKLLGDLWQRLSHSRKKLMEIFHIILNQICLLPILESSCDNIQGFIEEFLQIFSSLLQE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 KRFLRDYDALFPVAEDISLLQQASSVLDETRTAYILQAVESAWEGVDRRKATDAKDPSVI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KRFLRDYDALFPVAEDISLLQQASSVLDETRTAYILQAVESAWEGVDRRKATDAKDPSVI 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 EEPNGEPNGVTVTAEAVSQASSHPENSEEEECMGAAAAVGPAMCGVELDSLISQVKDLLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EEPNGEPNGVTVTAEAVSQASSHPENSEEEECMGAAAAVGPAMCGVELDSLISQVKDLLP 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE2 DLGEGFILACLEYYHYDPEQVINNILEERLAPTLSQLDRNLDREMKPDPTPLLTSRHNVF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DLGEGFILACLEYYHYDPEQVINNILEERLAPTLSQLDRNLDREMKPDPTPLLTSRHNVF 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE2 QNDEFDVFSRDSVDLSRVHKGKSTRKEENTRSLLNDKRAVAAQRQRYEQYSVVVEEVPLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QNDEFDVFSRDSVDLSRVHKGKSTRKEENTRSLLNDKRAVAAQRQRYEQYSVVVEEVPLQ 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE2 PGESLPYHSVYYEDEYDDTYDGNQVGANDADSDDELISRRPFTIPQVLRTKVPREGQEED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PGESLPYHSVYYEDEYDDTYDGNQVGANDADSDDELISRRPFTIPQVLRTKVPREGQEED 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE2 DDDEEDDADEEAPKPDHFVQDPAVLREKAEARRMAFLAKKGYRHDSSTAVAGSPRGHGQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DDDEEDDADEEAPKPDHFVQDPAVLREKAEARRMAFLAKKGYRHDSSTAVAGSPRGHGQS 670 680 690 700 710 720 730 740 750 pF1KE2 RETTQERRKKEANKATRANHNRRTMADRKRSKGMIPS ::::::::::::::::::::::::::::::::::::: XP_016 RETTQERRKKEANKATRANHNRRTMADRKRSKGMIPS 730 740 750 >>XP_016884488 (OMIM: 614216) PREDICTED: activating sign (757 aa) initn: 5065 init1: 5065 opt: 5065 Z-score: 4594.3 bits: 860.8 E(85289): 0 Smith-Waterman score: 5065; 100.0% identity (100.0% similar) in 757 aa overlap (1-757:1-757) 10 20 30 40 50 60 pF1KE2 MPALPLDQLQITHKDPKTGKLRTSPALHPEQKADRYFVLYKPPPKDNIPALVEEYLERAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MPALPLDQLQITHKDPKTGKLRTSPALHPEQKADRYFVLYKPPPKDNIPALVEEYLERAT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 FVANDLDWLLALPHDKFWCQVIFDETLQKCLDSYLRYVPRKFDEGVASAPEVVDMQKRLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FVANDLDWLLALPHDKFWCQVIFDETLQKCLDSYLRYVPRKFDEGVASAPEVVDMQKRLH 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 RSVFLTFLRMSTHKESKDHFISPSAFGEILYNNFLFDIPKILDLCVLFGKGNSPLLQKMI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RSVFLTFLRMSTHKESKDHFISPSAFGEILYNNFLFDIPKILDLCVLFGKGNSPLLQKMI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 GNIFTQQPSYYSDLDETLPTILQVFSNILQHCGLQGDGANTTPQKLEERGRLTPSDMPLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GNIFTQQPSYYSDLDETLPTILQVFSNILQHCGLQGDGANTTPQKLEERGRLTPSDMPLL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 ELKDIVLYLCDTCTTLWAFLDIFPLACQTFQKHDFCYRLASFYEAAIPEMESAIKKRRLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ELKDIVLYLCDTCTTLWAFLDIFPLACQTFQKHDFCYRLASFYEAAIPEMESAIKKRRLE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 DSKLLGDLWQRLSHSRKKLMEIFHIILNQICLLPILESSCDNIQGFIEEFLQIFSSLLQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DSKLLGDLWQRLSHSRKKLMEIFHIILNQICLLPILESSCDNIQGFIEEFLQIFSSLLQE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 KRFLRDYDALFPVAEDISLLQQASSVLDETRTAYILQAVESAWEGVDRRKATDAKDPSVI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KRFLRDYDALFPVAEDISLLQQASSVLDETRTAYILQAVESAWEGVDRRKATDAKDPSVI 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 EEPNGEPNGVTVTAEAVSQASSHPENSEEEECMGAAAAVGPAMCGVELDSLISQVKDLLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EEPNGEPNGVTVTAEAVSQASSHPENSEEEECMGAAAAVGPAMCGVELDSLISQVKDLLP 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE2 DLGEGFILACLEYYHYDPEQVINNILEERLAPTLSQLDRNLDREMKPDPTPLLTSRHNVF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DLGEGFILACLEYYHYDPEQVINNILEERLAPTLSQLDRNLDREMKPDPTPLLTSRHNVF 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE2 QNDEFDVFSRDSVDLSRVHKGKSTRKEENTRSLLNDKRAVAAQRQRYEQYSVVVEEVPLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QNDEFDVFSRDSVDLSRVHKGKSTRKEENTRSLLNDKRAVAAQRQRYEQYSVVVEEVPLQ 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE2 PGESLPYHSVYYEDEYDDTYDGNQVGANDADSDDELISRRPFTIPQVLRTKVPREGQEED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PGESLPYHSVYYEDEYDDTYDGNQVGANDADSDDELISRRPFTIPQVLRTKVPREGQEED 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE2 DDDEEDDADEEAPKPDHFVQDPAVLREKAEARRMAFLAKKGYRHDSSTAVAGSPRGHGQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DDDEEDDADEEAPKPDHFVQDPAVLREKAEARRMAFLAKKGYRHDSSTAVAGSPRGHGQS 670 680 690 700 710 720 730 740 750 pF1KE2 RETTQERRKKEANKATRANHNRRTMADRKRSKGMIPS ::::::::::::::::::::::::::::::::::::: XP_016 RETTQERRKKEANKATRANHNRRTMADRKRSKGMIPS 730 740 750 >>XP_016884489 (OMIM: 614216) PREDICTED: activating sign (757 aa) initn: 5065 init1: 5065 opt: 5065 Z-score: 4594.3 bits: 860.8 E(85289): 0 Smith-Waterman score: 5065; 100.0% identity (100.0% similar) in 757 aa overlap (1-757:1-757) 10 20 30 40 50 60 pF1KE2 MPALPLDQLQITHKDPKTGKLRTSPALHPEQKADRYFVLYKPPPKDNIPALVEEYLERAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MPALPLDQLQITHKDPKTGKLRTSPALHPEQKADRYFVLYKPPPKDNIPALVEEYLERAT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 FVANDLDWLLALPHDKFWCQVIFDETLQKCLDSYLRYVPRKFDEGVASAPEVVDMQKRLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FVANDLDWLLALPHDKFWCQVIFDETLQKCLDSYLRYVPRKFDEGVASAPEVVDMQKRLH 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 RSVFLTFLRMSTHKESKDHFISPSAFGEILYNNFLFDIPKILDLCVLFGKGNSPLLQKMI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RSVFLTFLRMSTHKESKDHFISPSAFGEILYNNFLFDIPKILDLCVLFGKGNSPLLQKMI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 GNIFTQQPSYYSDLDETLPTILQVFSNILQHCGLQGDGANTTPQKLEERGRLTPSDMPLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GNIFTQQPSYYSDLDETLPTILQVFSNILQHCGLQGDGANTTPQKLEERGRLTPSDMPLL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 ELKDIVLYLCDTCTTLWAFLDIFPLACQTFQKHDFCYRLASFYEAAIPEMESAIKKRRLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ELKDIVLYLCDTCTTLWAFLDIFPLACQTFQKHDFCYRLASFYEAAIPEMESAIKKRRLE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 DSKLLGDLWQRLSHSRKKLMEIFHIILNQICLLPILESSCDNIQGFIEEFLQIFSSLLQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DSKLLGDLWQRLSHSRKKLMEIFHIILNQICLLPILESSCDNIQGFIEEFLQIFSSLLQE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 KRFLRDYDALFPVAEDISLLQQASSVLDETRTAYILQAVESAWEGVDRRKATDAKDPSVI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KRFLRDYDALFPVAEDISLLQQASSVLDETRTAYILQAVESAWEGVDRRKATDAKDPSVI 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 EEPNGEPNGVTVTAEAVSQASSHPENSEEEECMGAAAAVGPAMCGVELDSLISQVKDLLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EEPNGEPNGVTVTAEAVSQASSHPENSEEEECMGAAAAVGPAMCGVELDSLISQVKDLLP 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE2 DLGEGFILACLEYYHYDPEQVINNILEERLAPTLSQLDRNLDREMKPDPTPLLTSRHNVF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DLGEGFILACLEYYHYDPEQVINNILEERLAPTLSQLDRNLDREMKPDPTPLLTSRHNVF 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE2 QNDEFDVFSRDSVDLSRVHKGKSTRKEENTRSLLNDKRAVAAQRQRYEQYSVVVEEVPLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QNDEFDVFSRDSVDLSRVHKGKSTRKEENTRSLLNDKRAVAAQRQRYEQYSVVVEEVPLQ 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE2 PGESLPYHSVYYEDEYDDTYDGNQVGANDADSDDELISRRPFTIPQVLRTKVPREGQEED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PGESLPYHSVYYEDEYDDTYDGNQVGANDADSDDELISRRPFTIPQVLRTKVPREGQEED 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE2 DDDEEDDADEEAPKPDHFVQDPAVLREKAEARRMAFLAKKGYRHDSSTAVAGSPRGHGQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DDDEEDDADEEAPKPDHFVQDPAVLREKAEARRMAFLAKKGYRHDSSTAVAGSPRGHGQS 670 680 690 700 710 720 730 740 750 pF1KE2 RETTQERRKKEANKATRANHNRRTMADRKRSKGMIPS ::::::::::::::::::::::::::::::::::::: XP_016 RETTQERRKKEANKATRANHNRRTMADRKRSKGMIPS 730 740 750 >>XP_005261832 (OMIM: 614216) PREDICTED: activating sign (757 aa) initn: 5065 init1: 5065 opt: 5065 Z-score: 4594.3 bits: 860.8 E(85289): 0 Smith-Waterman score: 5065; 100.0% identity (100.0% similar) in 757 aa overlap (1-757:1-757) 10 20 30 40 50 60 pF1KE2 MPALPLDQLQITHKDPKTGKLRTSPALHPEQKADRYFVLYKPPPKDNIPALVEEYLERAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MPALPLDQLQITHKDPKTGKLRTSPALHPEQKADRYFVLYKPPPKDNIPALVEEYLERAT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 FVANDLDWLLALPHDKFWCQVIFDETLQKCLDSYLRYVPRKFDEGVASAPEVVDMQKRLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 FVANDLDWLLALPHDKFWCQVIFDETLQKCLDSYLRYVPRKFDEGVASAPEVVDMQKRLH 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 RSVFLTFLRMSTHKESKDHFISPSAFGEILYNNFLFDIPKILDLCVLFGKGNSPLLQKMI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RSVFLTFLRMSTHKESKDHFISPSAFGEILYNNFLFDIPKILDLCVLFGKGNSPLLQKMI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 GNIFTQQPSYYSDLDETLPTILQVFSNILQHCGLQGDGANTTPQKLEERGRLTPSDMPLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GNIFTQQPSYYSDLDETLPTILQVFSNILQHCGLQGDGANTTPQKLEERGRLTPSDMPLL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 ELKDIVLYLCDTCTTLWAFLDIFPLACQTFQKHDFCYRLASFYEAAIPEMESAIKKRRLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ELKDIVLYLCDTCTTLWAFLDIFPLACQTFQKHDFCYRLASFYEAAIPEMESAIKKRRLE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 DSKLLGDLWQRLSHSRKKLMEIFHIILNQICLLPILESSCDNIQGFIEEFLQIFSSLLQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DSKLLGDLWQRLSHSRKKLMEIFHIILNQICLLPILESSCDNIQGFIEEFLQIFSSLLQE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 KRFLRDYDALFPVAEDISLLQQASSVLDETRTAYILQAVESAWEGVDRRKATDAKDPSVI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KRFLRDYDALFPVAEDISLLQQASSVLDETRTAYILQAVESAWEGVDRRKATDAKDPSVI 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 EEPNGEPNGVTVTAEAVSQASSHPENSEEEECMGAAAAVGPAMCGVELDSLISQVKDLLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EEPNGEPNGVTVTAEAVSQASSHPENSEEEECMGAAAAVGPAMCGVELDSLISQVKDLLP 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE2 DLGEGFILACLEYYHYDPEQVINNILEERLAPTLSQLDRNLDREMKPDPTPLLTSRHNVF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DLGEGFILACLEYYHYDPEQVINNILEERLAPTLSQLDRNLDREMKPDPTPLLTSRHNVF 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE2 QNDEFDVFSRDSVDLSRVHKGKSTRKEENTRSLLNDKRAVAAQRQRYEQYSVVVEEVPLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QNDEFDVFSRDSVDLSRVHKGKSTRKEENTRSLLNDKRAVAAQRQRYEQYSVVVEEVPLQ 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE2 PGESLPYHSVYYEDEYDDTYDGNQVGANDADSDDELISRRPFTIPQVLRTKVPREGQEED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PGESLPYHSVYYEDEYDDTYDGNQVGANDADSDDELISRRPFTIPQVLRTKVPREGQEED 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE2 DDDEEDDADEEAPKPDHFVQDPAVLREKAEARRMAFLAKKGYRHDSSTAVAGSPRGHGQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DDDEEDDADEEAPKPDHFVQDPAVLREKAEARRMAFLAKKGYRHDSSTAVAGSPRGHGQS 670 680 690 700 710 720 730 740 750 pF1KE2 RETTQERRKKEANKATRANHNRRTMADRKRSKGMIPS ::::::::::::::::::::::::::::::::::::: XP_005 RETTQERRKKEANKATRANHNRRTMADRKRSKGMIPS 730 740 750 >>NP_115580 (OMIM: 614216) activating signal cointegrato (757 aa) initn: 5065 init1: 5065 opt: 5065 Z-score: 4594.3 bits: 860.8 E(85289): 0 Smith-Waterman score: 5065; 100.0% identity (100.0% similar) in 757 aa overlap (1-757:1-757) 10 20 30 40 50 60 pF1KE2 MPALPLDQLQITHKDPKTGKLRTSPALHPEQKADRYFVLYKPPPKDNIPALVEEYLERAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 MPALPLDQLQITHKDPKTGKLRTSPALHPEQKADRYFVLYKPPPKDNIPALVEEYLERAT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 FVANDLDWLLALPHDKFWCQVIFDETLQKCLDSYLRYVPRKFDEGVASAPEVVDMQKRLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 FVANDLDWLLALPHDKFWCQVIFDETLQKCLDSYLRYVPRKFDEGVASAPEVVDMQKRLH 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 RSVFLTFLRMSTHKESKDHFISPSAFGEILYNNFLFDIPKILDLCVLFGKGNSPLLQKMI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 RSVFLTFLRMSTHKESKDHFISPSAFGEILYNNFLFDIPKILDLCVLFGKGNSPLLQKMI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 GNIFTQQPSYYSDLDETLPTILQVFSNILQHCGLQGDGANTTPQKLEERGRLTPSDMPLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 GNIFTQQPSYYSDLDETLPTILQVFSNILQHCGLQGDGANTTPQKLEERGRLTPSDMPLL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 ELKDIVLYLCDTCTTLWAFLDIFPLACQTFQKHDFCYRLASFYEAAIPEMESAIKKRRLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 ELKDIVLYLCDTCTTLWAFLDIFPLACQTFQKHDFCYRLASFYEAAIPEMESAIKKRRLE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 DSKLLGDLWQRLSHSRKKLMEIFHIILNQICLLPILESSCDNIQGFIEEFLQIFSSLLQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 DSKLLGDLWQRLSHSRKKLMEIFHIILNQICLLPILESSCDNIQGFIEEFLQIFSSLLQE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 KRFLRDYDALFPVAEDISLLQQASSVLDETRTAYILQAVESAWEGVDRRKATDAKDPSVI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 KRFLRDYDALFPVAEDISLLQQASSVLDETRTAYILQAVESAWEGVDRRKATDAKDPSVI 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 EEPNGEPNGVTVTAEAVSQASSHPENSEEEECMGAAAAVGPAMCGVELDSLISQVKDLLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 EEPNGEPNGVTVTAEAVSQASSHPENSEEEECMGAAAAVGPAMCGVELDSLISQVKDLLP 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE2 DLGEGFILACLEYYHYDPEQVINNILEERLAPTLSQLDRNLDREMKPDPTPLLTSRHNVF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 DLGEGFILACLEYYHYDPEQVINNILEERLAPTLSQLDRNLDREMKPDPTPLLTSRHNVF 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE2 QNDEFDVFSRDSVDLSRVHKGKSTRKEENTRSLLNDKRAVAAQRQRYEQYSVVVEEVPLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 QNDEFDVFSRDSVDLSRVHKGKSTRKEENTRSLLNDKRAVAAQRQRYEQYSVVVEEVPLQ 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE2 PGESLPYHSVYYEDEYDDTYDGNQVGANDADSDDELISRRPFTIPQVLRTKVPREGQEED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 PGESLPYHSVYYEDEYDDTYDGNQVGANDADSDDELISRRPFTIPQVLRTKVPREGQEED 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE2 DDDEEDDADEEAPKPDHFVQDPAVLREKAEARRMAFLAKKGYRHDSSTAVAGSPRGHGQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 DDDEEDDADEEAPKPDHFVQDPAVLREKAEARRMAFLAKKGYRHDSSTAVAGSPRGHGQS 670 680 690 700 710 720 730 740 750 pF1KE2 RETTQERRKKEANKATRANHNRRTMADRKRSKGMIPS ::::::::::::::::::::::::::::::::::::: NP_115 RETTQERRKKEANKATRANHNRRTMADRKRSKGMIPS 730 740 750 >>XP_016884481 (OMIM: 614216) PREDICTED: activating sign (811 aa) initn: 5065 init1: 5065 opt: 5065 Z-score: 4593.8 bits: 860.8 E(85289): 0 Smith-Waterman score: 5065; 100.0% identity (100.0% similar) in 757 aa overlap (1-757:55-811) 10 20 30 pF1KE2 MPALPLDQLQITHKDPKTGKLRTSPALHPE :::::::::::::::::::::::::::::: XP_016 SAPEQALPPGVCVSALFFPSIFLSGGSRSTMPALPLDQLQITHKDPKTGKLRTSPALHPE 30 40 50 60 70 80 40 50 60 70 80 90 pF1KE2 QKADRYFVLYKPPPKDNIPALVEEYLERATFVANDLDWLLALPHDKFWCQVIFDETLQKC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QKADRYFVLYKPPPKDNIPALVEEYLERATFVANDLDWLLALPHDKFWCQVIFDETLQKC 90 100 110 120 130 140 100 110 120 130 140 150 pF1KE2 LDSYLRYVPRKFDEGVASAPEVVDMQKRLHRSVFLTFLRMSTHKESKDHFISPSAFGEIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LDSYLRYVPRKFDEGVASAPEVVDMQKRLHRSVFLTFLRMSTHKESKDHFISPSAFGEIL 150 160 170 180 190 200 160 170 180 190 200 210 pF1KE2 YNNFLFDIPKILDLCVLFGKGNSPLLQKMIGNIFTQQPSYYSDLDETLPTILQVFSNILQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YNNFLFDIPKILDLCVLFGKGNSPLLQKMIGNIFTQQPSYYSDLDETLPTILQVFSNILQ 210 220 230 240 250 260 220 230 240 250 260 270 pF1KE2 HCGLQGDGANTTPQKLEERGRLTPSDMPLLELKDIVLYLCDTCTTLWAFLDIFPLACQTF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HCGLQGDGANTTPQKLEERGRLTPSDMPLLELKDIVLYLCDTCTTLWAFLDIFPLACQTF 270 280 290 300 310 320 280 290 300 310 320 330 pF1KE2 QKHDFCYRLASFYEAAIPEMESAIKKRRLEDSKLLGDLWQRLSHSRKKLMEIFHIILNQI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QKHDFCYRLASFYEAAIPEMESAIKKRRLEDSKLLGDLWQRLSHSRKKLMEIFHIILNQI 330 340 350 360 370 380 340 350 360 370 380 390 pF1KE2 CLLPILESSCDNIQGFIEEFLQIFSSLLQEKRFLRDYDALFPVAEDISLLQQASSVLDET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CLLPILESSCDNIQGFIEEFLQIFSSLLQEKRFLRDYDALFPVAEDISLLQQASSVLDET 390 400 410 420 430 440 400 410 420 430 440 450 pF1KE2 RTAYILQAVESAWEGVDRRKATDAKDPSVIEEPNGEPNGVTVTAEAVSQASSHPENSEEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RTAYILQAVESAWEGVDRRKATDAKDPSVIEEPNGEPNGVTVTAEAVSQASSHPENSEEE 450 460 470 480 490 500 460 470 480 490 500 510 pF1KE2 ECMGAAAAVGPAMCGVELDSLISQVKDLLPDLGEGFILACLEYYHYDPEQVINNILEERL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ECMGAAAAVGPAMCGVELDSLISQVKDLLPDLGEGFILACLEYYHYDPEQVINNILEERL 510 520 530 540 550 560 520 530 540 550 560 570 pF1KE2 APTLSQLDRNLDREMKPDPTPLLTSRHNVFQNDEFDVFSRDSVDLSRVHKGKSTRKEENT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 APTLSQLDRNLDREMKPDPTPLLTSRHNVFQNDEFDVFSRDSVDLSRVHKGKSTRKEENT 570 580 590 600 610 620 580 590 600 610 620 630 pF1KE2 RSLLNDKRAVAAQRQRYEQYSVVVEEVPLQPGESLPYHSVYYEDEYDDTYDGNQVGANDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RSLLNDKRAVAAQRQRYEQYSVVVEEVPLQPGESLPYHSVYYEDEYDDTYDGNQVGANDA 630 640 650 660 670 680 640 650 660 670 680 690 pF1KE2 DSDDELISRRPFTIPQVLRTKVPREGQEEDDDDEEDDADEEAPKPDHFVQDPAVLREKAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DSDDELISRRPFTIPQVLRTKVPREGQEEDDDDEEDDADEEAPKPDHFVQDPAVLREKAE 690 700 710 720 730 740 700 710 720 730 740 750 pF1KE2 ARRMAFLAKKGYRHDSSTAVAGSPRGHGQSRETTQERRKKEANKATRANHNRRTMADRKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ARRMAFLAKKGYRHDSSTAVAGSPRGHGQSRETTQERRKKEANKATRANHNRRTMADRKR 750 760 770 780 790 800 pF1KE2 SKGMIPS ::::::: XP_016 SKGMIPS 810 >>XP_011528748 (OMIM: 614216) PREDICTED: activating sign (762 aa) initn: 4517 init1: 4517 opt: 5045 Z-score: 4576.1 bits: 857.4 E(85289): 0 Smith-Waterman score: 5045; 99.3% identity (99.3% similar) in 762 aa overlap (1-757:1-762) 10 20 30 40 50 60 pF1KE2 MPALPLDQLQITHKDPKTGKLRTSPALHPEQKADRYFVLYKPPPKDNIPALVEEYLERAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MPALPLDQLQITHKDPKTGKLRTSPALHPEQKADRYFVLYKPPPKDNIPALVEEYLERAT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 FVANDLDWLLALPHDKFWCQVIFDETLQKCLDSYLRYVPRKFDEGVASAPEVVDMQKRLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FVANDLDWLLALPHDKFWCQVIFDETLQKCLDSYLRYVPRKFDEGVASAPEVVDMQKRLH 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 RSVFLTFLRMSTHKESKDHFISPSAFGEILYNNFLFDIPKILDLCVLFGKGNSPLLQKMI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RSVFLTFLRMSTHKESKDHFISPSAFGEILYNNFLFDIPKILDLCVLFGKGNSPLLQKMI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 GNIFTQQPSYYSDLDETLPTILQVFSNILQHCGLQGDGANTTPQKLEERGRLTPSDMPLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GNIFTQQPSYYSDLDETLPTILQVFSNILQHCGLQGDGANTTPQKLEERGRLTPSDMPLL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 ELKDIVLYLCDTCTTLWAFLDIFPLACQTFQKHDFCYRLASFYEAAIPEMESAIKKRRLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ELKDIVLYLCDTCTTLWAFLDIFPLACQTFQKHDFCYRLASFYEAAIPEMESAIKKRRLE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 DSKLLGDLWQRLSHSRKKLMEIFHIILNQICLLPILESSCDNIQGFIEEFLQIFSSLLQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DSKLLGDLWQRLSHSRKKLMEIFHIILNQICLLPILESSCDNIQGFIEEFLQIFSSLLQE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 KRFLRDYDALFPVAEDISLLQQASSVLDETRTAYILQAVESAWEGVDRRKATDAKDPSVI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KRFLRDYDALFPVAEDISLLQQASSVLDETRTAYILQAVESAWEGVDRRKATDAKDPSVI 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 EEPNGEPNGVTVTAEAVSQASSHPENSEEEECMGAAAAVGPAMCGVELDSLISQVKDLLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EEPNGEPNGVTVTAEAVSQASSHPENSEEEECMGAAAAVGPAMCGVELDSLISQVKDLLP 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE2 DLGEGFILACLEYYHYDPEQVINNILEERLAPTLSQLDRNLDREMKPDPTPLLTSRHNVF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DLGEGFILACLEYYHYDPEQVINNILEERLAPTLSQLDRNLDREMKPDPTPLLTSRHNVF 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE2 QNDEFDVFSRDSVDLSRVHKGKSTRKEENTRSLLNDKRAVAAQRQRYEQYSVVVEEVPLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QNDEFDVFSRDSVDLSRVHKGKSTRKEENTRSLLNDKRAVAAQRQRYEQYSVVVEEVPLQ 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE2 PGESLPYHSVYYEDEYDDTYDGNQVGANDADSDDELISRRPFTIPQVLRTKVPREGQEED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PGESLPYHSVYYEDEYDDTYDGNQVGANDADSDDELISRRPFTIPQVLRTKVPREGQEED 610 620 630 640 650 660 670 680 690 700 710 pF1KE2 DDDEEDDADEEAPK-----PDHFVQDPAVLREKAEARRMAFLAKKGYRHDSSTAVAGSPR :::::::::::::: ::::::::::::::::::::::::::::::::::::::::: XP_011 DDDEEDDADEEAPKVPPWQPDHFVQDPAVLREKAEARRMAFLAKKGYRHDSSTAVAGSPR 670 680 690 700 710 720 720 730 740 750 pF1KE2 GHGQSRETTQERRKKEANKATRANHNRRTMADRKRSKGMIPS :::::::::::::::::::::::::::::::::::::::::: XP_011 GHGQSRETTQERRKKEANKATRANHNRRTMADRKRSKGMIPS 730 740 750 760 >>XP_016884485 (OMIM: 614216) PREDICTED: activating sign (762 aa) initn: 4517 init1: 4517 opt: 5045 Z-score: 4576.1 bits: 857.4 E(85289): 0 Smith-Waterman score: 5045; 99.3% identity (99.3% similar) in 762 aa overlap (1-757:1-762) 10 20 30 40 50 60 pF1KE2 MPALPLDQLQITHKDPKTGKLRTSPALHPEQKADRYFVLYKPPPKDNIPALVEEYLERAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MPALPLDQLQITHKDPKTGKLRTSPALHPEQKADRYFVLYKPPPKDNIPALVEEYLERAT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 FVANDLDWLLALPHDKFWCQVIFDETLQKCLDSYLRYVPRKFDEGVASAPEVVDMQKRLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FVANDLDWLLALPHDKFWCQVIFDETLQKCLDSYLRYVPRKFDEGVASAPEVVDMQKRLH 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 RSVFLTFLRMSTHKESKDHFISPSAFGEILYNNFLFDIPKILDLCVLFGKGNSPLLQKMI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RSVFLTFLRMSTHKESKDHFISPSAFGEILYNNFLFDIPKILDLCVLFGKGNSPLLQKMI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 GNIFTQQPSYYSDLDETLPTILQVFSNILQHCGLQGDGANTTPQKLEERGRLTPSDMPLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GNIFTQQPSYYSDLDETLPTILQVFSNILQHCGLQGDGANTTPQKLEERGRLTPSDMPLL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 ELKDIVLYLCDTCTTLWAFLDIFPLACQTFQKHDFCYRLASFYEAAIPEMESAIKKRRLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ELKDIVLYLCDTCTTLWAFLDIFPLACQTFQKHDFCYRLASFYEAAIPEMESAIKKRRLE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 DSKLLGDLWQRLSHSRKKLMEIFHIILNQICLLPILESSCDNIQGFIEEFLQIFSSLLQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DSKLLGDLWQRLSHSRKKLMEIFHIILNQICLLPILESSCDNIQGFIEEFLQIFSSLLQE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 KRFLRDYDALFPVAEDISLLQQASSVLDETRTAYILQAVESAWEGVDRRKATDAKDPSVI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KRFLRDYDALFPVAEDISLLQQASSVLDETRTAYILQAVESAWEGVDRRKATDAKDPSVI 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 EEPNGEPNGVTVTAEAVSQASSHPENSEEEECMGAAAAVGPAMCGVELDSLISQVKDLLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EEPNGEPNGVTVTAEAVSQASSHPENSEEEECMGAAAAVGPAMCGVELDSLISQVKDLLP 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE2 DLGEGFILACLEYYHYDPEQVINNILEERLAPTLSQLDRNLDREMKPDPTPLLTSRHNVF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DLGEGFILACLEYYHYDPEQVINNILEERLAPTLSQLDRNLDREMKPDPTPLLTSRHNVF 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE2 QNDEFDVFSRDSVDLSRVHKGKSTRKEENTRSLLNDKRAVAAQRQRYEQYSVVVEEVPLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QNDEFDVFSRDSVDLSRVHKGKSTRKEENTRSLLNDKRAVAAQRQRYEQYSVVVEEVPLQ 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE2 PGESLPYHSVYYEDEYDDTYDGNQVGANDADSDDELISRRPFTIPQVLRTKVPREGQEED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PGESLPYHSVYYEDEYDDTYDGNQVGANDADSDDELISRRPFTIPQVLRTKVPREGQEED 610 620 630 640 650 660 670 680 690 700 710 pF1KE2 DDDEEDDADEEAPK-----PDHFVQDPAVLREKAEARRMAFLAKKGYRHDSSTAVAGSPR :::::::::::::: ::::::::::::::::::::::::::::::::::::::::: XP_016 DDDEEDDADEEAPKVPPWQPDHFVQDPAVLREKAEARRMAFLAKKGYRHDSSTAVAGSPR 670 680 690 700 710 720 720 730 740 750 pF1KE2 GHGQSRETTQERRKKEANKATRANHNRRTMADRKRSKGMIPS :::::::::::::::::::::::::::::::::::::::::: XP_016 GHGQSRETTQERRKKEANKATRANHNRRTMADRKRSKGMIPS 730 740 750 760 >>XP_011528744 (OMIM: 614216) PREDICTED: activating sign (762 aa) initn: 4517 init1: 4517 opt: 5045 Z-score: 4576.1 bits: 857.4 E(85289): 0 Smith-Waterman score: 5045; 99.3% identity (99.3% similar) in 762 aa overlap (1-757:1-762) 10 20 30 40 50 60 pF1KE2 MPALPLDQLQITHKDPKTGKLRTSPALHPEQKADRYFVLYKPPPKDNIPALVEEYLERAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MPALPLDQLQITHKDPKTGKLRTSPALHPEQKADRYFVLYKPPPKDNIPALVEEYLERAT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 FVANDLDWLLALPHDKFWCQVIFDETLQKCLDSYLRYVPRKFDEGVASAPEVVDMQKRLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FVANDLDWLLALPHDKFWCQVIFDETLQKCLDSYLRYVPRKFDEGVASAPEVVDMQKRLH 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 RSVFLTFLRMSTHKESKDHFISPSAFGEILYNNFLFDIPKILDLCVLFGKGNSPLLQKMI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RSVFLTFLRMSTHKESKDHFISPSAFGEILYNNFLFDIPKILDLCVLFGKGNSPLLQKMI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 GNIFTQQPSYYSDLDETLPTILQVFSNILQHCGLQGDGANTTPQKLEERGRLTPSDMPLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GNIFTQQPSYYSDLDETLPTILQVFSNILQHCGLQGDGANTTPQKLEERGRLTPSDMPLL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 ELKDIVLYLCDTCTTLWAFLDIFPLACQTFQKHDFCYRLASFYEAAIPEMESAIKKRRLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ELKDIVLYLCDTCTTLWAFLDIFPLACQTFQKHDFCYRLASFYEAAIPEMESAIKKRRLE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 DSKLLGDLWQRLSHSRKKLMEIFHIILNQICLLPILESSCDNIQGFIEEFLQIFSSLLQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DSKLLGDLWQRLSHSRKKLMEIFHIILNQICLLPILESSCDNIQGFIEEFLQIFSSLLQE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 KRFLRDYDALFPVAEDISLLQQASSVLDETRTAYILQAVESAWEGVDRRKATDAKDPSVI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KRFLRDYDALFPVAEDISLLQQASSVLDETRTAYILQAVESAWEGVDRRKATDAKDPSVI 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 EEPNGEPNGVTVTAEAVSQASSHPENSEEEECMGAAAAVGPAMCGVELDSLISQVKDLLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EEPNGEPNGVTVTAEAVSQASSHPENSEEEECMGAAAAVGPAMCGVELDSLISQVKDLLP 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE2 DLGEGFILACLEYYHYDPEQVINNILEERLAPTLSQLDRNLDREMKPDPTPLLTSRHNVF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DLGEGFILACLEYYHYDPEQVINNILEERLAPTLSQLDRNLDREMKPDPTPLLTSRHNVF 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE2 QNDEFDVFSRDSVDLSRVHKGKSTRKEENTRSLLNDKRAVAAQRQRYEQYSVVVEEVPLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QNDEFDVFSRDSVDLSRVHKGKSTRKEENTRSLLNDKRAVAAQRQRYEQYSVVVEEVPLQ 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE2 PGESLPYHSVYYEDEYDDTYDGNQVGANDADSDDELISRRPFTIPQVLRTKVPREGQEED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PGESLPYHSVYYEDEYDDTYDGNQVGANDADSDDELISRRPFTIPQVLRTKVPREGQEED 610 620 630 640 650 660 670 680 690 700 710 pF1KE2 DDDEEDDADEEAPK-----PDHFVQDPAVLREKAEARRMAFLAKKGYRHDSSTAVAGSPR :::::::::::::: ::::::::::::::::::::::::::::::::::::::::: XP_011 DDDEEDDADEEAPKVPPWQPDHFVQDPAVLREKAEARRMAFLAKKGYRHDSSTAVAGSPR 670 680 690 700 710 720 720 730 740 750 pF1KE2 GHGQSRETTQERRKKEANKATRANHNRRTMADRKRSKGMIPS :::::::::::::::::::::::::::::::::::::::::: XP_011 GHGQSRETTQERRKKEANKATRANHNRRTMADRKRSKGMIPS 730 740 750 760 >>XP_011528746 (OMIM: 614216) PREDICTED: activating sign (762 aa) initn: 4517 init1: 4517 opt: 5045 Z-score: 4576.1 bits: 857.4 E(85289): 0 Smith-Waterman score: 5045; 99.3% identity (99.3% similar) in 762 aa overlap (1-757:1-762) 10 20 30 40 50 60 pF1KE2 MPALPLDQLQITHKDPKTGKLRTSPALHPEQKADRYFVLYKPPPKDNIPALVEEYLERAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MPALPLDQLQITHKDPKTGKLRTSPALHPEQKADRYFVLYKPPPKDNIPALVEEYLERAT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 FVANDLDWLLALPHDKFWCQVIFDETLQKCLDSYLRYVPRKFDEGVASAPEVVDMQKRLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FVANDLDWLLALPHDKFWCQVIFDETLQKCLDSYLRYVPRKFDEGVASAPEVVDMQKRLH 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 RSVFLTFLRMSTHKESKDHFISPSAFGEILYNNFLFDIPKILDLCVLFGKGNSPLLQKMI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RSVFLTFLRMSTHKESKDHFISPSAFGEILYNNFLFDIPKILDLCVLFGKGNSPLLQKMI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 GNIFTQQPSYYSDLDETLPTILQVFSNILQHCGLQGDGANTTPQKLEERGRLTPSDMPLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GNIFTQQPSYYSDLDETLPTILQVFSNILQHCGLQGDGANTTPQKLEERGRLTPSDMPLL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 ELKDIVLYLCDTCTTLWAFLDIFPLACQTFQKHDFCYRLASFYEAAIPEMESAIKKRRLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ELKDIVLYLCDTCTTLWAFLDIFPLACQTFQKHDFCYRLASFYEAAIPEMESAIKKRRLE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 DSKLLGDLWQRLSHSRKKLMEIFHIILNQICLLPILESSCDNIQGFIEEFLQIFSSLLQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DSKLLGDLWQRLSHSRKKLMEIFHIILNQICLLPILESSCDNIQGFIEEFLQIFSSLLQE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 KRFLRDYDALFPVAEDISLLQQASSVLDETRTAYILQAVESAWEGVDRRKATDAKDPSVI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KRFLRDYDALFPVAEDISLLQQASSVLDETRTAYILQAVESAWEGVDRRKATDAKDPSVI 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 EEPNGEPNGVTVTAEAVSQASSHPENSEEEECMGAAAAVGPAMCGVELDSLISQVKDLLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EEPNGEPNGVTVTAEAVSQASSHPENSEEEECMGAAAAVGPAMCGVELDSLISQVKDLLP 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE2 DLGEGFILACLEYYHYDPEQVINNILEERLAPTLSQLDRNLDREMKPDPTPLLTSRHNVF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DLGEGFILACLEYYHYDPEQVINNILEERLAPTLSQLDRNLDREMKPDPTPLLTSRHNVF 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE2 QNDEFDVFSRDSVDLSRVHKGKSTRKEENTRSLLNDKRAVAAQRQRYEQYSVVVEEVPLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QNDEFDVFSRDSVDLSRVHKGKSTRKEENTRSLLNDKRAVAAQRQRYEQYSVVVEEVPLQ 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE2 PGESLPYHSVYYEDEYDDTYDGNQVGANDADSDDELISRRPFTIPQVLRTKVPREGQEED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PGESLPYHSVYYEDEYDDTYDGNQVGANDADSDDELISRRPFTIPQVLRTKVPREGQEED 610 620 630 640 650 660 670 680 690 700 710 pF1KE2 DDDEEDDADEEAPK-----PDHFVQDPAVLREKAEARRMAFLAKKGYRHDSSTAVAGSPR :::::::::::::: ::::::::::::::::::::::::::::::::::::::::: XP_011 DDDEEDDADEEAPKVPPWQPDHFVQDPAVLREKAEARRMAFLAKKGYRHDSSTAVAGSPR 670 680 690 700 710 720 720 730 740 750 pF1KE2 GHGQSRETTQERRKKEANKATRANHNRRTMADRKRSKGMIPS :::::::::::::::::::::::::::::::::::::::::: XP_011 GHGQSRETTQERRKKEANKATRANHNRRTMADRKRSKGMIPS 730 740 750 760 757 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 12:55:43 2016 done: Sun Nov 6 12:55:44 2016 Total Scan time: 12.380 Total Display time: 0.240 Function used was FASTA [36.3.4 Apr, 2011]