Result of FASTA (omim) for
pFN21AE3275
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE3275, 688 aa
1>>>pF1KE3275 688 - 688 aa - 688 aa
Library: /omim/omim.rfq.tfa
62246620 residues in 87639 sequences
Statistics: Expectation_n fit: rho(ln(x))= 8.2145+/-0.000643; mu= 7.4369+/- 0.039
mean_var=673.6523+/-156.248, 0's: 0 Z-trim(115.1): 1460 B-trim: 33 in 1/54
Lambda= 0.049415
statistics sampled from 23788 (25692) to 23788 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.642), E-opt: 0.2 (0.293), width: 16
Scan time: 10.470
The best scores are: opt bits E(87639)
NP_005151 (OMIM: 109636) beta-adrenergic receptor ( 688) 4673 350.2 1.5e-95
NP_001610 (OMIM: 109635) beta-adrenergic receptor ( 689) 4042 305.3 5.3e-82
XP_011543075 (OMIM: 109635) PREDICTED: beta-adrene ( 659) 3825 289.7 2.4e-77
XP_011528277 (OMIM: 109636) PREDICTED: beta-adrene ( 523) 3603 273.7 1.3e-72
NP_001004105 (OMIM: 600869) G protein-coupled rece ( 560) 1128 97.3 1.7e-19
NP_001004106 (OMIM: 600869) G protein-coupled rece ( 576) 1128 97.4 1.7e-19
NP_002073 (OMIM: 600869) G protein-coupled recepto ( 589) 1128 97.4 1.7e-19
XP_006714922 (OMIM: 600869) PREDICTED: G protein-c ( 557) 1103 95.6 5.8e-19
XP_006714921 (OMIM: 600869) PREDICTED: G protein-c ( 559) 1103 95.6 5.8e-19
NP_005299 (OMIM: 600870) G protein-coupled recepto ( 590) 1081 94.0 1.8e-18
NP_892027 (OMIM: 137026) G protein-coupled recepto ( 578) 1077 93.7 2.1e-18
NP_001004057 (OMIM: 137026) G protein-coupled rece ( 532) 1068 93.0 3.2e-18
XP_005269765 (OMIM: 600870) PREDICTED: G protein-c ( 558) 1065 92.8 3.8e-18
NP_001004056 (OMIM: 137026) G protein-coupled rece ( 546) 1061 92.5 4.6e-18
NP_005298 (OMIM: 137026) G protein-coupled recepto ( 500) 1052 91.8 6.9e-18
XP_011532839 (OMIM: 600869) PREDICTED: G protein-c ( 550) 1050 91.8 7.9e-18
NP_002920 (OMIM: 180381,613411) rhodopsin kinase [ ( 563) 969 86.0 4.4e-16
NP_631948 (OMIM: 606987) rhodopsin kinase [Homo sa ( 553) 963 85.6 5.8e-16
XP_016861206 (OMIM: 606987) PREDICTED: rhodopsin k ( 553) 963 85.6 5.8e-16
XP_016863545 (OMIM: 137026) PREDICTED: G protein-c ( 440) 882 79.6 2.9e-14
XP_016863543 (OMIM: 137026) PREDICTED: G protein-c ( 486) 882 79.7 3e-14
XP_016863544 (OMIM: 137026) PREDICTED: G protein-c ( 454) 866 78.5 6.5e-14
NP_001337102 (OMIM: 137026) G protein-coupled rece ( 384) 845 76.8 1.7e-13
XP_016863546 (OMIM: 137026) PREDICTED: G protein-c ( 384) 845 76.8 1.7e-13
XP_016863547 (OMIM: 137026) PREDICTED: G protein-c ( 384) 845 76.8 1.7e-13
XP_016863549 (OMIM: 137026) PREDICTED: G protein-c ( 384) 845 76.8 1.7e-13
XP_016863548 (OMIM: 137026) PREDICTED: G protein-c ( 384) 845 76.8 1.7e-13
XP_016863552 (OMIM: 137026) PREDICTED: G protein-c ( 338) 836 76.1 2.5e-13
XP_011511751 (OMIM: 137026) PREDICTED: G protein-c ( 585) 836 76.6 3.2e-13
XP_016863541 (OMIM: 137026) PREDICTED: G protein-c ( 591) 836 76.6 3.2e-13
XP_011511750 (OMIM: 137026) PREDICTED: G protein-c ( 611) 836 76.6 3.2e-13
XP_011511749 (OMIM: 137026) PREDICTED: G protein-c ( 617) 836 76.6 3.2e-13
XP_011511752 (OMIM: 137026) PREDICTED: G protein-c ( 571) 827 75.9 4.9e-13
XP_016863551 (OMIM: 137026) PREDICTED: G protein-c ( 367) 808 74.2 1e-12
XP_016863550 (OMIM: 137026) PREDICTED: G protein-c ( 367) 808 74.2 1e-12
XP_006713943 (OMIM: 137026) PREDICTED: G protein-c ( 367) 808 74.2 1e-12
XP_005248019 (OMIM: 137026) PREDICTED: G protein-c ( 367) 808 74.2 1e-12
XP_011511755 (OMIM: 137026) PREDICTED: G protein-c ( 525) 765 71.4 1e-11
XP_005274634 (OMIM: 300075,300844,303600) PREDICTE ( 710) 763 71.5 1.3e-11
XP_006724570 (OMIM: 300075,300844,303600) PREDICTE ( 711) 763 71.5 1.3e-11
XP_016885208 (OMIM: 300075,300844,303600) PREDICTE ( 711) 763 71.5 1.3e-11
XP_005274630 (OMIM: 300075,300844,303600) PREDICTE ( 739) 763 71.6 1.3e-11
XP_016885207 (OMIM: 300075,300844,303600) PREDICTE ( 711) 755 71.0 1.9e-11
XP_016885202 (OMIM: 300075,300844,303600) PREDICTE ( 712) 755 71.0 1.9e-11
XP_016885206 (OMIM: 300075,300844,303600) PREDICTE ( 712) 755 71.0 1.9e-11
XP_016885203 (OMIM: 300075,300844,303600) PREDICTE ( 712) 755 71.0 1.9e-11
XP_011543865 (OMIM: 300075,300844,303600) PREDICTE ( 712) 755 71.0 1.9e-11
XP_016885205 (OMIM: 300075,300844,303600) PREDICTE ( 712) 755 71.0 1.9e-11
XP_016885204 (OMIM: 300075,300844,303600) PREDICTE ( 712) 755 71.0 1.9e-11
NP_004577 (OMIM: 300075,300844,303600) ribosomal p ( 740) 755 71.0 1.9e-11
>>NP_005151 (OMIM: 109636) beta-adrenergic receptor kina (688 aa)
initn: 4673 init1: 4673 opt: 4673 Z-score: 1836.5 bits: 350.2 E(87639): 1.5e-95
Smith-Waterman score: 4673; 100.0% identity (100.0% similar) in 688 aa overlap (1-688:1-688)
10 20 30 40 50 60
pF1KE3 MADLEAVLADVSYLMAMEKSKATPAARASKRIVLPEPSIRSVMQKYLAERNEITFDKIFN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 MADLEAVLADVSYLMAMEKSKATPAARASKRIVLPEPSIRSVMQKYLAERNEITFDKIFN
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 QKIGFLLFKDFCLNEINEAVPQVKFYEEIKEYEKLDNEEDRLCRSRQIYDAYIMKELLSC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 QKIGFLLFKDFCLNEINEAVPQVKFYEEIKEYEKLDNEEDRLCRSRQIYDAYIMKELLSC
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 SHPFSKQAVEHVQSHLSKKQVTSTLFQPYIEEICESLRGDIFQKFMESDKFTRFCQWKNV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 SHPFSKQAVEHVQSHLSKKQVTSTLFQPYIEEICESLRGDIFQKFMESDKFTRFCQWKNV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 ELNIHLTMNEFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 ELNIHLTMNEFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNER
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 IMLSLVSTGDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFSEKEMRFYATE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 IMLSLVSTGDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFSEKEMRFYATE
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE3 IILGLEHMHNRFVVYRDLKPANILLDEHGHARISDLGLACDFSKKKPHASVGTHGYMAPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 IILGLEHMHNRFVVYRDLKPANILLDEHGHARISDLGLACDFSKKKPHASVGTHGYMAPE
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE3 VLQKGTAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTVNVELPDTFSPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 VLQKGTAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTVNVELPDTFSPE
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE3 LKSLLEGLLQRDVSKRLGCHGGGSQEVKEHSFFKGVDWQHVYLQKYPPPLIPPRGEVNAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 LKSLLEGLLQRDVSKRLGCHGGGSQEVKEHSFFKGVDWQHVYLQKYPPPLIPPRGEVNAA
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE3 DAFDIGSFDEEDTKGIKLLDCDQELYKNFPLVISERWQQEVTETVYEAVNADTDKIEARK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 DAFDIGSFDEEDTKGIKLLDCDQELYKNFPLVISERWQQEVTETVYEAVNADTDKIEARK
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE3 RAKNKQLGHEEDYALGKDCIMHGYMLKLGNPFLTQWQRRYFYLFPNRLEWRGEGESRQNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 RAKNKQLGHEEDYALGKDCIMHGYMLKLGNPFLTQWQRRYFYLFPNRLEWRGEGESRQNL
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE3 LTMEQILSVEETQIKDKKCILFRIKGGKQFVLQCESDPEFVQWKKELNETFKEAQRLLRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 LTMEQILSVEETQIKDKKCILFRIKGGKQFVLQCESDPEFVQWKKELNETFKEAQRLLRR
610 620 630 640 650 660
670 680
pF1KE3 APKFLNKPRSGTVELPKPSLCHRNSNGL
::::::::::::::::::::::::::::
NP_005 APKFLNKPRSGTVELPKPSLCHRNSNGL
670 680
>>NP_001610 (OMIM: 109635) beta-adrenergic receptor kina (689 aa)
initn: 4034 init1: 4034 opt: 4042 Z-score: 1593.3 bits: 305.3 E(87639): 5.3e-82
Smith-Waterman score: 4042; 84.0% identity (96.1% similar) in 689 aa overlap (1-688:1-689)
10 20 30 40 50 60
pF1KE3 MADLEAVLADVSYLMAMEKSKATPAARASKRIVLPEPSIRSVMQKYLAERNEITFDKIFN
::::::::::::::::::::::::::::::.:.:::::::::::::: .:.:.::.:::.
NP_001 MADLEAVLADVSYLMAMEKSKATPAARASKKILLPEPSIRSVMQKYLEDRGEVTFEKIFS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 QKIGFLLFKDFCLNEINEAVPQVKFYEEIKEYEKLDNEEDRLCRSRQIYDAYIMKELLSC
::.:.:::.:::::...:: : :.::::::.::::..::.:. :::.:.:.:::::::.:
NP_001 QKLGYLLFRDFCLNHLEEARPLVEFYEEIKKYEKLETEEERVARSREIFDSYIMKELLAC
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 SHPFSKQAVEHVQSHLSKKQVTSTLFQPYIEEICESLRGDIFQKFMESDKFTRFCQWKNV
::::::.:.::::.::.:::: ::::::::::..::::.::::.::::::::::::::
NP_001 SHPFSKSATEHVQGHLGKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQWKNV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 ELNIHLTMNEFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNER
:::::::::.::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNER
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 IMLSLVSTGDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFSEKEMRFYATE
:::::::::::::::::.::::::::: ::::::::::::::::::::::: .:::::.:
NP_001 IMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAE
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE3 IILGLEHMHNRFVVYRDLKPANILLDEHGHARISDLGLACDFSKKKPHASVGTHGYMAPE
::::::::::::::::::::::::::::::.:::::::::::::::::::::::::::::
NP_001 IILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPE
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE3 VLQKGTAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTVNVELPDTFSPE
:::::.::::::::::::::::::::::::::::::::::::::::::. :::::.::::
NP_001 VLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPE
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE3 LKSLLEGLLQRDVSKRLGCHGGGSQEVKEHSFFKGVDWQHVYLQKYPPPLIPPRGEVNAA
:.:::::::::::..:::: : :.::::: ::...::: :.::::::::::::::::::
NP_001 LRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAA
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE3 DAFDIGSFDEEDTKGIKLLDCDQELYKNFPLVISERWQQEVTETVYEAVNADTDKIEARK
:::::::::::::::::::: :::::.::::.:::::::::.:::....::.::..::::
NP_001 DAFDIGSFDEEDTKGIKLLDSDQELYRNFPLTISERWQQEVAETVFDTINAETDRLEARK
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE3 RAKNKQLGHEEDYALGKDCIMHGYMLKLGNPFLTQWQRRYFYLFPNRLEWRGEGESRQNL
.:::::::::::::::::::::::: :.:::::::::::::::::::::::::::. :.:
NP_001 KAKNKQLGHEEDYALGKDCIMHGYMSKMGNPFLTQWQRRYFYLFPNRLEWRGEGEAPQSL
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE3 LTMEQILSVEETQIKDKKCILFRIKGGKQFVLQCESDPEFVQWKKELNETFKEAQRLLRR
::::.: ::::::::..::.:..:.:::::.:::.::::.::::::: ....:::.:..:
NP_001 LTMEEIQSVEETQIKERKCLLLKIRGGKQFILQCDSDPELVQWKKELRDAYREAQQLVQR
610 620 630 640 650 660
670 680
pF1KE3 APKFLNKPRSGTVELPKPSLCHRNS-NGL
.::. ::::: .::: : : .:.: :::
NP_001 VPKMKNKPRSPVVELSKVPLVQRGSANGL
670 680
>>XP_011543075 (OMIM: 109635) PREDICTED: beta-adrenergic (659 aa)
initn: 3817 init1: 3817 opt: 3825 Z-score: 1509.9 bits: 289.7 E(87639): 2.4e-77
Smith-Waterman score: 3825; 83.4% identity (95.9% similar) in 652 aa overlap (38-688:8-659)
10 20 30 40 50 60
pF1KE3 LADVSYLMAMEKSKATPAARASKRIVLPEPSIRSVMQKYLAERNEITFDKIFNQKIGFLL
:::::::::: .:.:.::.:::.::.:.::
XP_011 MGKLKLQSIRSVMQKYLEDRGEVTFEKIFSQKLGYLL
10 20 30
70 80 90 100 110 120
pF1KE3 FKDFCLNEINEAVPQVKFYEEIKEYEKLDNEEDRLCRSRQIYDAYIMKELLSCSHPFSKQ
:.:::::...:: : :.::::::.::::..::.:. :::.:.:.:::::::.:::::::.
XP_011 FRDFCLNHLEEARPLVEFYEEIKKYEKLETEEERVARSREIFDSYIMKELLACSHPFSKS
40 50 60 70 80 90
130 140 150 160 170 180
pF1KE3 AVEHVQSHLSKKQVTSTLFQPYIEEICESLRGDIFQKFMESDKFTRFCQWKNVELNIHLT
:.::::.::.:::: ::::::::::..::::.::::.:::::::::::::::::::::
XP_011 ATEHVQGHLGKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQWKNVELNIHLT
100 110 120 130 140 150
190 200 210 220 230 240
pF1KE3 MNEFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVS
::.:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVS
160 170 180 190 200 210
250 260 270 280 290 300
pF1KE3 TGDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFSEKEMRFYATEIILGLEH
::::::::::.::::::::: ::::::::::::::::::::::: .:::::.::::::::
XP_011 TGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEH
220 230 240 250 260 270
310 320 330 340 350 360
pF1KE3 MHNRFVVYRDLKPANILLDEHGHARISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGTA
:::::::::::::::::::::::.::::::::::::::::::::::::::::::::::.:
XP_011 MHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVA
280 290 300 310 320 330
370 380 390 400 410 420
pF1KE3 YDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTVNVELPDTFSPELKSLLEG
:::::::::::::::::::::::::::::::::::::::::. :::::.:::::.:::::
XP_011 YDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEG
340 350 360 370 380 390
430 440 450 460 470 480
pF1KE3 LLQRDVSKRLGCHGGGSQEVKEHSFFKGVDWQHVYLQKYPPPLIPPRGEVNAADAFDIGS
::::::..:::: : :.::::: ::...::: :.:::::::::::::::::::::::::
XP_011 LLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAFDIGS
400 410 420 430 440 450
490 500 510 520 530 540
pF1KE3 FDEEDTKGIKLLDCDQELYKNFPLVISERWQQEVTETVYEAVNADTDKIEARKRAKNKQL
::::::::::::: :::::.::::.:::::::::.:::....::.::..::::.::::::
XP_011 FDEEDTKGIKLLDSDQELYRNFPLTISERWQQEVAETVFDTINAETDRLEARKKAKNKQL
460 470 480 490 500 510
550 560 570 580 590 600
pF1KE3 GHEEDYALGKDCIMHGYMLKLGNPFLTQWQRRYFYLFPNRLEWRGEGESRQNLLTMEQIL
:::::::::::::::::: :.:::::::::::::::::::::::::::. :.:::::.:
XP_011 GHEEDYALGKDCIMHGYMSKMGNPFLTQWQRRYFYLFPNRLEWRGEGEAPQSLLTMEEIQ
520 530 540 550 560 570
610 620 630 640 650 660
pF1KE3 SVEETQIKDKKCILFRIKGGKQFVLQCESDPEFVQWKKELNETFKEAQRLLRRAPKFLNK
::::::::..::.:..:.:::::.:::.::::.::::::: ....:::.:..:.::. ::
XP_011 SVEETQIKERKCLLLKIRGGKQFILQCDSDPELVQWKKELRDAYREAQQLVQRVPKMKNK
580 590 600 610 620 630
670 680
pF1KE3 PRSGTVELPKPSLCHRNS-NGL
::: .::: : : .:.: :::
XP_011 PRSPVVELSKVPLVQRGSANGL
640 650
>>XP_011528277 (OMIM: 109636) PREDICTED: beta-adrenergic (523 aa)
initn: 3603 init1: 3603 opt: 3603 Z-score: 1425.1 bits: 273.7 E(87639): 1.3e-72
Smith-Waterman score: 3603; 100.0% identity (100.0% similar) in 523 aa overlap (166-688:1-523)
140 150 160 170 180 190
pF1KE3 LSKKQVTSTLFQPYIEEICESLRGDIFQKFMESDKFTRFCQWKNVELNIHLTMNEFSVHR
::::::::::::::::::::::::::::::
XP_011 MESDKFTRFCQWKNVELNIHLTMNEFSVHR
10 20 30
200 210 220 230 240 250
pF1KE3 IIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIV
40 50 60 70 80 90
260 270 280 290 300 310
pF1KE3 CMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFSEKEMRFYATEIILGLEHMHNRFVVY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFSEKEMRFYATEIILGLEHMHNRFVVY
100 110 120 130 140 150
320 330 340 350 360 370
pF1KE3 RDLKPANILLDEHGHARISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGTAYDSSADWF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RDLKPANILLDEHGHARISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGTAYDSSADWF
160 170 180 190 200 210
380 390 400 410 420 430
pF1KE3 SLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTVNVELPDTFSPELKSLLEGLLQRDVSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTVNVELPDTFSPELKSLLEGLLQRDVSK
220 230 240 250 260 270
440 450 460 470 480 490
pF1KE3 RLGCHGGGSQEVKEHSFFKGVDWQHVYLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RLGCHGGGSQEVKEHSFFKGVDWQHVYLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKG
280 290 300 310 320 330
500 510 520 530 540 550
pF1KE3 IKLLDCDQELYKNFPLVISERWQQEVTETVYEAVNADTDKIEARKRAKNKQLGHEEDYAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IKLLDCDQELYKNFPLVISERWQQEVTETVYEAVNADTDKIEARKRAKNKQLGHEEDYAL
340 350 360 370 380 390
560 570 580 590 600 610
pF1KE3 GKDCIMHGYMLKLGNPFLTQWQRRYFYLFPNRLEWRGEGESRQNLLTMEQILSVEETQIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GKDCIMHGYMLKLGNPFLTQWQRRYFYLFPNRLEWRGEGESRQNLLTMEQILSVEETQIK
400 410 420 430 440 450
620 630 640 650 660 670
pF1KE3 DKKCILFRIKGGKQFVLQCESDPEFVQWKKELNETFKEAQRLLRRAPKFLNKPRSGTVEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DKKCILFRIKGGKQFVLQCESDPEFVQWKKELNETFKEAQRLLRRAPKFLNKPRSGTVEL
460 470 480 490 500 510
680
pF1KE3 PKPSLCHRNSNGL
:::::::::::::
XP_011 PKPSLCHRNSNGL
520
>>NP_001004105 (OMIM: 600869) G protein-coupled receptor (560 aa)
initn: 861 init1: 341 opt: 1128 Z-score: 471.3 bits: 97.3 E(87639): 1.7e-19
Smith-Waterman score: 1128; 38.9% identity (64.7% similar) in 530 aa overlap (3-524:2-518)
10 20 30 40 50
pF1KE3 MADLEAVLADVSYLMAMEKSKATPAARASK-RIVLPEPSIRSVMQKYLA-ERNEITFDKI
.:: ..:.. : : : . .. ....: : .: : : . . :. ::. .. .
NP_001 MELENIVANTVLLKAREGGGGNRKGKSKKWRQMLQFPHISQCEELRLSLERDYHSLCE-
10 20 30 40 50
60 70 80 90 100 110
pF1KE3 FNQKIGFLLFKDFCLNEINEAVPQVKFYEEIKEYEKLDNEEDRLCRSRQIYDAYIMKELL
: :: :::..:: .. : : : . . ::: ... . : .::. . .. .
NP_001 -RQPIGRLLFREFCATR-PELSRCVAFLDGVAEYEVTPDDKRKAC-GRQLTQNFLSHTGP
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE3 SCSHPFSKQAVEHVQSHLSKKQVTSTLFQPYIEEICESLRGDIFQKFMESDKFTRFCQWK
. .: : . ..: . . ::: . : : : ...: :.:: :::
NP_001 DLIPEVPRQLVTNCTQRLEQGPC-KDLFQELTRLTHEYLSVAPFADYLDSIYFNRFLQWK
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE3 NVELNIHLTMNEFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALN
.: . .: : : .:..:.:::::: .:. :::::: : :.::::: ..::..:::
NP_001 WLERQ-PVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALN
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE3 ERIMLSLVSTGDCPFIVCMTYAFHTPDKLCFILDLMNGGDLH---YHLSQHGVFSEKEMR
:. .: :.. :.: ..::..: : ::..: :::::::. ::..: : : : .
NP_001 EKQILEKVNSR---FVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAG-FPEARAV
240 250 260 270 280
300 310 320 330 340 350
pF1KE3 FYATEIILGLEHMHNRFVVYRDLKPANILLDEHGHARISDLGLACDFSKKKP-HASVGTH
:::.:: ::: .: . .::::::: :::::.::: :::::::: . . .. :::
NP_001 FYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTV
290 300 310 320 330 340
360 370 380 390 400 410
pF1KE3 GYMAPEVLQKGTAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHE-IDRMTLTVNVEL
:::::::. :. : : ::..:::.:.... :.:::.:.: : :.: ..:.. : :
NP_001 GYMAPEVV-KNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEY
350 360 370 380 390 400
420 430 440 450 460 470
pF1KE3 PDTFSPELKSLLEGLLQRDVSKRLGCHGGGSQEVKEHSFFKGVDWQHVYLQKYPPPLIPP
. :::. .:: :: .: ..::::.::...::::: .:: ...... ::. :
NP_001 SERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPD
410 420 430 440 450 460
480 490 500 510 520 530
pF1KE3 RGEVNAADAFDIGSFDEEDTKGIKLLDCDQELYKNFPL-VISERWQQEVTETVYEAVNAD
. :..:: .:. .::..: ::..:..: . ::.:..::
NP_001 PQAIYCKDVLDIEQFS--TVKGVELEPTDQDFYQKFATGSVPIPWQNEMVETECFQELNV
470 480 490 500 510 520
540 550 560 570 580 590
pF1KE3 TDKIEARKRAKNKQLGHEEDYALGKDCIMHGYMLKLGNPFLTQWQRRYFYLFPNRLEWRG
NP_001 FGLDGSVPPDLDWKGQPPAPPKKGLLQRLFSRQR
530 540 550 560
>>NP_001004106 (OMIM: 600869) G protein-coupled receptor (576 aa)
initn: 861 init1: 341 opt: 1128 Z-score: 471.2 bits: 97.4 E(87639): 1.7e-19
Smith-Waterman score: 1128; 38.9% identity (64.7% similar) in 530 aa overlap (3-524:2-518)
10 20 30 40 50
pF1KE3 MADLEAVLADVSYLMAMEKSKATPAARASK-RIVLPEPSIRSVMQKYLA-ERNEITFDKI
.:: ..:.. : : : . .. ....: : .: : : . . :. ::. .. .
NP_001 MELENIVANTVLLKAREGGGGNRKGKSKKWRQMLQFPHISQCEELRLSLERDYHSLCE-
10 20 30 40 50
60 70 80 90 100 110
pF1KE3 FNQKIGFLLFKDFCLNEINEAVPQVKFYEEIKEYEKLDNEEDRLCRSRQIYDAYIMKELL
: :: :::..:: .. : : : . . ::: ... . : .::. . .. .
NP_001 -RQPIGRLLFREFCATR-PELSRCVAFLDGVAEYEVTPDDKRKAC-GRQLTQNFLSHTGP
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE3 SCSHPFSKQAVEHVQSHLSKKQVTSTLFQPYIEEICESLRGDIFQKFMESDKFTRFCQWK
. .: : . ..: . . ::: . : : : ...: :.:: :::
NP_001 DLIPEVPRQLVTNCTQRLEQGPC-KDLFQELTRLTHEYLSVAPFADYLDSIYFNRFLQWK
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE3 NVELNIHLTMNEFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALN
.: . .: : : .:..:.:::::: .:. :::::: : :.::::: ..::..:::
NP_001 WLERQ-PVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALN
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE3 ERIMLSLVSTGDCPFIVCMTYAFHTPDKLCFILDLMNGGDLH---YHLSQHGVFSEKEMR
:. .: :.. :.: ..::..: : ::..: :::::::. ::..: : : : .
NP_001 EKQILEKVNSR---FVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAG-FPEARAV
240 250 260 270 280
300 310 320 330 340 350
pF1KE3 FYATEIILGLEHMHNRFVVYRDLKPANILLDEHGHARISDLGLACDFSKKKP-HASVGTH
:::.:: ::: .: . .::::::: :::::.::: :::::::: . . .. :::
NP_001 FYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTV
290 300 310 320 330 340
360 370 380 390 400 410
pF1KE3 GYMAPEVLQKGTAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHE-IDRMTLTVNVEL
:::::::. :. : : ::..:::.:.... :.:::.:.: : :.: ..:.. : :
NP_001 GYMAPEVV-KNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEY
350 360 370 380 390 400
420 430 440 450 460 470
pF1KE3 PDTFSPELKSLLEGLLQRDVSKRLGCHGGGSQEVKEHSFFKGVDWQHVYLQKYPPPLIPP
. :::. .:: :: .: ..::::.::...::::: .:: ...... ::. :
NP_001 SERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPD
410 420 430 440 450 460
480 490 500 510 520 530
pF1KE3 RGEVNAADAFDIGSFDEEDTKGIKLLDCDQELYKNFPL-VISERWQQEVTETVYEAVNAD
. :..:: .:. .::..: ::..:..: . ::.:..::
NP_001 PQAIYCKDVLDIEQFS--TVKGVELEPTDQDFYQKFATGSVPIPWQNEMVETECFQELNV
470 480 490 500 510 520
540 550 560 570 580 590
pF1KE3 TDKIEARKRAKNKQLGHEEDYALGKDCIMHGYMLKLGNPFLTQWQRRYFYLFPNRLEWRG
NP_001 FGLDGSVPPDLDWKGQPPAPPKKGLLQRLFSRQDCCGNCSDSEEELPTRL
530 540 550 560 570
>>NP_002073 (OMIM: 600869) G protein-coupled receptor ki (589 aa)
initn: 861 init1: 341 opt: 1128 Z-score: 471.1 bits: 97.4 E(87639): 1.7e-19
Smith-Waterman score: 1128; 38.9% identity (64.7% similar) in 530 aa overlap (3-524:2-518)
10 20 30 40 50
pF1KE3 MADLEAVLADVSYLMAMEKSKATPAARASK-RIVLPEPSIRSVMQKYLA-ERNEITFDKI
.:: ..:.. : : : . .. ....: : .: : : . . :. ::. .. .
NP_002 MELENIVANTVLLKAREGGGGNRKGKSKKWRQMLQFPHISQCEELRLSLERDYHSLCE-
10 20 30 40 50
60 70 80 90 100 110
pF1KE3 FNQKIGFLLFKDFCLNEINEAVPQVKFYEEIKEYEKLDNEEDRLCRSRQIYDAYIMKELL
: :: :::..:: .. : : : . . ::: ... . : .::. . .. .
NP_002 -RQPIGRLLFREFCATR-PELSRCVAFLDGVAEYEVTPDDKRKAC-GRQLTQNFLSHTGP
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE3 SCSHPFSKQAVEHVQSHLSKKQVTSTLFQPYIEEICESLRGDIFQKFMESDKFTRFCQWK
. .: : . ..: . . ::: . : : : ...: :.:: :::
NP_002 DLIPEVPRQLVTNCTQRLEQGPC-KDLFQELTRLTHEYLSVAPFADYLDSIYFNRFLQWK
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE3 NVELNIHLTMNEFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALN
.: . .: : : .:..:.:::::: .:. :::::: : :.::::: ..::..:::
NP_002 WLERQ-PVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALN
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE3 ERIMLSLVSTGDCPFIVCMTYAFHTPDKLCFILDLMNGGDLH---YHLSQHGVFSEKEMR
:. .: :.. :.: ..::..: : ::..: :::::::. ::..: : : : .
NP_002 EKQILEKVNSR---FVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAG-FPEARAV
240 250 260 270 280
300 310 320 330 340 350
pF1KE3 FYATEIILGLEHMHNRFVVYRDLKPANILLDEHGHARISDLGLACDFSKKKP-HASVGTH
:::.:: ::: .: . .::::::: :::::.::: :::::::: . . .. :::
NP_002 FYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTV
290 300 310 320 330 340
360 370 380 390 400 410
pF1KE3 GYMAPEVLQKGTAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHE-IDRMTLTVNVEL
:::::::. :. : : ::..:::.:.... :.:::.:.: : :.: ..:.. : :
NP_002 GYMAPEVV-KNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEY
350 360 370 380 390 400
420 430 440 450 460 470
pF1KE3 PDTFSPELKSLLEGLLQRDVSKRLGCHGGGSQEVKEHSFFKGVDWQHVYLQKYPPPLIPP
. :::. .:: :: .: ..::::.::...::::: .:: ...... ::. :
NP_002 SERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPD
410 420 430 440 450 460
480 490 500 510 520 530
pF1KE3 RGEVNAADAFDIGSFDEEDTKGIKLLDCDQELYKNFPL-VISERWQQEVTETVYEAVNAD
. :..:: .:. .::..: ::..:..: . ::.:..::
NP_002 PQAIYCKDVLDIEQFS--TVKGVELEPTDQDFYQKFATGSVPIPWQNEMVETECFQELNV
470 480 490 500 510 520
540 550 560 570 580 590
pF1KE3 TDKIEARKRAKNKQLGHEEDYALGKDCIMHGYMLKLGNPFLTQWQRRYFYLFPNRLEWRG
NP_002 FGLDGSVPPDLDWKGQPPAPPKKGLLQRLFSRQRIAVETAATARKSSPPASSPQPEAPTS
530 540 550 560 570 580
>>XP_006714922 (OMIM: 600869) PREDICTED: G protein-coupl (557 aa)
initn: 861 init1: 341 opt: 1103 Z-score: 461.7 bits: 95.6 E(87639): 5.8e-19
Smith-Waterman score: 1103; 40.9% identity (66.0% similar) in 470 aa overlap (61-524:28-486)
40 50 60 70 80 90
pF1KE3 RIVLPEPSIRSVMQKYLAERNEITFDKIFNQKIGFLLFKDFCLNEINEAVPQVKFYEEIK
: :: :::..:: .. : : : . .
XP_006 MLQFPHISQCEELRLSLERDYHSLCERQPIGRLLFREFCATR-PELSRCVAFLDGVA
10 20 30 40 50
100 110 120 130 140 150
pF1KE3 EYEKLDNEEDRLCRSRQIYDAYIMKELLSCSHPFSKQAVEHVQSHLSKKQVTSTLFQPYI
::: ... . : .::. . .. . . .: : . ..: .. . :::
XP_006 EYEVTPDDKRKAC-GRQLTQNFLSHTGPDLIPEVPRQLVTNCTQRL-EQGPCKDLFQELT
60 70 80 90 100 110
160 170 180 190 200 210
pF1KE3 EEICESLRGDIFQKFMESDKFTRFCQWKNVELNIHLTMNEFSVHRIIGRGGFGEVYGCRK
. : : : ...: :.:: ::: .: . .: : : .:..:.:::::: .:.
XP_006 RLTHEYLSVAPFADYLDSIYFNRFLQWKWLERQ-PVTKNTFRQYRVLGKGGFGEVCACQV
120 130 140 150 160 170
220 230 240 250 260 270
pF1KE3 ADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMTYAFHTPDKLCFI
:::::: : :.::::: ..::..::::. .: :.. :.: ..::..: : ::..
XP_006 RATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNS---RFVVSLAYAYETKDALCLV
180 190 200 210 220 230
280 290 300 310 320
pF1KE3 LDLMNGGDLH---YHLSQHGVFSEKEMRFYATEIILGLEHMHNRFVVYRDLKPANILLDE
: :::::::. ::..: : : : . :::.:: ::: .: . .::::::: :::::.
XP_006 LTLMNGGDLKFHIYHMGQAG-FPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDD
240 250 260 270 280
330 340 350 360 370 380
pF1KE3 HGHARISDLGLACDFSKKKP-HASVGTHGYMAPEVLQKGTAYDSSADWFSLGCMLFKLLR
::: :::::::: . . .. ::: :::::::. :. : : ::..:::.:....
XP_006 HGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVV-KNERYTFSPDWWALGCLLYEMIA
290 300 310 320 330 340
390 400 410 420 430 440
pF1KE3 GHSPFRQHKTKDKHE-IDRMTLTVNVELPDTFSPELKSLLEGLLQRDVSKRLGCHGGGSQ
:.:::.:.: : :.: ..:.. : : . :::. .:: :: .: ..::::.::...
XP_006 GQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQLLCKDPAERLGCRGGSAR
350 360 370 380 390 400
450 460 470 480 490 500
pF1KE3 EVKEHSFFKGVDWQHVYLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDCDQEL
::::: .:: ...... ::. : . :..:: .:. .::..: ::..
XP_006 EVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIYCKDVLDIEQFS--TVKGVELEPTDQDF
410 420 430 440 450 460
510 520 530 540 550 560
pF1KE3 YKNFPL-VISERWQQEVTETVYEAVNADTDKIEARKRAKNKQLGHEEDYALGKDCIMHGY
:..: . ::.:..::
XP_006 YQKFATGSVPIPWQNEMVETECFQELNVFGLDGSVPPDLDWKGQPPAPPKKGLLQRLFSR
470 480 490 500 510 520
>>XP_006714921 (OMIM: 600869) PREDICTED: G protein-coupl (559 aa)
initn: 861 init1: 341 opt: 1103 Z-score: 461.6 bits: 95.6 E(87639): 5.8e-19
Smith-Waterman score: 1103; 40.9% identity (66.0% similar) in 470 aa overlap (61-524:30-488)
40 50 60 70 80 90
pF1KE3 RIVLPEPSIRSVMQKYLAERNEITFDKIFNQKIGFLLFKDFCLNEINEAVPQVKFYEEIK
: :: :::..:: .. : : : . .
XP_006 MPHPCALGLWTQQLPSLPTERDYHSLCERQPIGRLLFREFCATR-PELSRCVAFLDGVA
10 20 30 40 50
100 110 120 130 140 150
pF1KE3 EYEKLDNEEDRLCRSRQIYDAYIMKELLSCSHPFSKQAVEHVQSHLSKKQVTSTLFQPYI
::: ... . : .::. . .. . . .: : . ..: .. . :::
XP_006 EYEVTPDDKRKAC-GRQLTQNFLSHTGPDLIPEVPRQLVTNCTQRL-EQGPCKDLFQELT
60 70 80 90 100 110
160 170 180 190 200 210
pF1KE3 EEICESLRGDIFQKFMESDKFTRFCQWKNVELNIHLTMNEFSVHRIIGRGGFGEVYGCRK
. : : : ...: :.:: ::: .: . .: : : .:..:.:::::: .:.
XP_006 RLTHEYLSVAPFADYLDSIYFNRFLQWKWLERQ-PVTKNTFRQYRVLGKGGFGEVCACQV
120 130 140 150 160 170
220 230 240 250 260 270
pF1KE3 ADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMTYAFHTPDKLCFI
:::::: : :.::::: ..::..::::. .: :.. :.: ..::..: : ::..
XP_006 RATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNS---RFVVSLAYAYETKDALCLV
180 190 200 210 220 230
280 290 300 310 320
pF1KE3 LDLMNGGDLH---YHLSQHGVFSEKEMRFYATEIILGLEHMHNRFVVYRDLKPANILLDE
: :::::::. ::..: : : : . :::.:: ::: .: . .::::::: :::::.
XP_006 LTLMNGGDLKFHIYHMGQAG-FPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDD
240 250 260 270 280 290
330 340 350 360 370 380
pF1KE3 HGHARISDLGLACDFSKKKP-HASVGTHGYMAPEVLQKGTAYDSSADWFSLGCMLFKLLR
::: :::::::: . . .. ::: :::::::. :. : : ::..:::.:....
XP_006 HGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVV-KNERYTFSPDWWALGCLLYEMIA
300 310 320 330 340 350
390 400 410 420 430 440
pF1KE3 GHSPFRQHKTKDKHE-IDRMTLTVNVELPDTFSPELKSLLEGLLQRDVSKRLGCHGGGSQ
:.:::.:.: : :.: ..:.. : : . :::. .:: :: .: ..::::.::...
XP_006 GQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQLLCKDPAERLGCRGGSAR
360 370 380 390 400 410
450 460 470 480 490 500
pF1KE3 EVKEHSFFKGVDWQHVYLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDCDQEL
::::: .:: ...... ::. : . :..:: .:. .::..: ::..
XP_006 EVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIYCKDVLDIEQFS--TVKGVELEPTDQDF
420 430 440 450 460
510 520 530 540 550 560
pF1KE3 YKNFPL-VISERWQQEVTETVYEAVNADTDKIEARKRAKNKQLGHEEDYALGKDCIMHGY
:..: . ::.:..::
XP_006 YQKFATGSVPIPWQNEMVETECFQELNVFGLDGSVPPDLDWKGQPPAPPKKGLLQRLFSR
470 480 490 500 510 520
>>NP_005299 (OMIM: 600870) G protein-coupled receptor ki (590 aa)
initn: 817 init1: 306 opt: 1081 Z-score: 453.0 bits: 94.0 E(87639): 1.8e-18
Smith-Waterman score: 1081; 37.6% identity (66.2% similar) in 532 aa overlap (3-524:2-518)
10 20 30 40 50
pF1KE3 MADLEAVLADVSYLMAMEKSKATPAARASK-RIVLPEPSIRSVMQ-KYLAERNEITF-DK
.:: ..:.. : : : . . ....: . .: : : . . . .:. .. ::
NP_005 MELENIVANTVLLKAREGGGGKRKGKSKKWKEILKFPHISQCEDLRRTIDRDYCSLCDK
10 20 30 40 50
60 70 80 90 100 110
pF1KE3 IFNQKIGFLLFKDFCLNEINEAVP-QVKFYEEIKEYEKLDNEEDRLCRSRQIYDAYIMKE
: :: :::..:: : .. ..: . . ::: . .: ....:. :. .
NP_005 ---QPIGRLLFRQFC--ETRPGLECYIQFLDSVAEYE-VTPDEKLGEKGKEIMTKYLTPK
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE3 LLSCSHPFSKQAVEHVQSHLSKKQVTSTLFQPYIEEICESLRGDIFQKFMESDKFTRFCQ
... : ... .: .: . ::. . . : :::. :.....: : :: :
NP_005 SPVFIAQVGQDLVSQTEEKLLQKPC-KELFSACAQSVHEYLRGEPFHEYLDSMFFDRFLQ
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE3 WKNVELNIHLTMNEFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLA
:: .: . .: : : .:..:.:::::: .:. :::::: : :.::::: ..::..:
NP_005 WKWLERQ-PVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMA
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE3 LNERIMLSLVSTGDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGV--FSEKEM
:::. .: :.. :.: ..::..: : ::..: .::::::..:. . : : :..
NP_005 LNEKQILEKVNS---QFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERA
240 250 260 270 280
300 310 320 330 340 350
pF1KE3 RFYATEIILGLEHMHNRFVVYRDLKPANILLDEHGHARISDLGLACDFSKKK-PHASVGT
:::.::. ::: .: . .::::::: :::::..:: :::::::: . . .. :::
NP_005 LFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGT
290 300 310 320 330 340
360 370 380 390 400 410
pF1KE3 HGYMAPEVLQKGTAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHE-IDRMTLTVNVE
::::::::.. : : :...:::.......:.:::: .: : :.: .:: .: ..
NP_005 VGYMAPEVLNNQR-YGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEV
350 360 370 380 390 400
420 430 440 450 460 470
pF1KE3 LPDTFSPELKSLLEGLLQRDVSKRLGCHGGGSQEVKEHSFFKGVDWQHVYLQKYPPPLIP
:: : ::. . :: .:...::::. :. :::.: ::........ ::..:
NP_005 YSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVP
410 420 430 440 450 460
480 490 500 510 520 530
pF1KE3 -PRGEVNAADAFDIGSFDEEDTKGIKLLDCDQELYKNFPL-VISERWQQEVTETVYEAVN
::. : :..:: .:. .::..: :...:..: .: ::.:. ::
NP_005 DPRA-VYCKDVLDIEQFS--TVKGVNLDHTDDDFYSKFSTGSVSIPWQNEMIETECFKEL
470 480 490 500 510 520
540 550 560 570 580 590
pF1KE3 ADTDKIEARKRAKNKQLGHEEDYALGKDCIMHGYMLKLGNPFLTQWQRRYFYLFPNRLEW
NP_005 NVFGPNGTLPPDLNRNHPPEPPKKGLLQRLFKRQHQNNSKSSPSSKTSFNHHINSNHVSS
530 540 550 560 570 580
688 residues in 1 query sequences
62246620 residues in 87639 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Jul 27 10:33:17 2017 done: Thu Jul 27 10:33:19 2017
Total Scan time: 10.470 Total Display time: 0.120
Function used was FASTA [36.3.4 Apr, 2011]