FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB6958, 238 aa 1>>>pF1KB6958 238 - 238 aa - 238 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.5721+/-0.000282; mu= 10.3260+/- 0.018 mean_var=127.8250+/-24.642, 0's: 0 Z-trim(122.5): 18 B-trim: 34 in 1/56 Lambda= 0.113440 statistics sampled from 40726 (40746) to 40726 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.808), E-opt: 0.2 (0.478), width: 16 Scan time: 7.470 The best scores are: opt bits E(85289) NP_996917 (OMIM: 131242,209880,613265,613712) endo ( 238) 1679 284.9 8.4e-77 XP_011526957 (OMIM: 131242,209880,613265,613712) P ( 244) 1581 268.9 5.7e-72 XP_006723797 (OMIM: 131242,209880,613265,613712) P ( 208) 1388 237.2 1.6e-62 NP_996915 (OMIM: 131242,209880,613265,613712) endo ( 219) 1388 237.2 1.7e-62 XP_005260369 (OMIM: 131242,209880,613265,613712) P ( 251) 1388 237.3 1.9e-62 NP_001289384 (OMIM: 131242,209880,613265,613712) e ( 198) 1383 236.4 2.8e-62 XP_005260370 (OMIM: 131242,209880,613265,613712) P ( 212) 1301 223.0 3.2e-58 NP_996916 (OMIM: 131242,209880,613265,613712) endo ( 224) 1293 221.7 8.3e-58 NP_001289385 (OMIM: 131242,209880,613265,613712) e ( 192) 1291 221.3 9.3e-58 XP_011512632 (OMIM: 131240,612798,615706) PREDICTE ( 212) 314 61.5 1.4e-09 NP_001946 (OMIM: 131240,612798,615706) endothelin- ( 212) 314 61.5 1.4e-09 XP_011512633 (OMIM: 131240,612798,615706) PREDICTE ( 212) 314 61.5 1.4e-09 XP_016865820 (OMIM: 131240,612798,615706) PREDICTE ( 212) 314 61.5 1.4e-09 XP_011512634 (OMIM: 131240,612798,615706) PREDICTE ( 211) 312 61.1 1.7e-09 NP_001161791 (OMIM: 131240,612798,615706) endothel ( 211) 312 61.1 1.7e-09 NP_001289198 (OMIM: 131241) endothelin-2 isoform 2 ( 145) 268 53.8 1.9e-07 NP_001947 (OMIM: 131241) endothelin-2 isoform 1 pr ( 178) 268 53.9 2.2e-07 XP_016856001 (OMIM: 131241) PREDICTED: endothelin- ( 132) 207 43.8 0.00018 >>NP_996917 (OMIM: 131242,209880,613265,613712) endothel (238 aa) initn: 1679 init1: 1679 opt: 1679 Z-score: 1499.9 bits: 284.9 E(85289): 8.4e-77 Smith-Waterman score: 1679; 100.0% identity (100.0% similar) in 238 aa overlap (1-238:1-238) 10 20 30 40 50 60 pF1KB6 MEPGLWLLFGLTVTSAAGFVPCSQSGDAGRRGVSQAPTAARSEGDCEETVAGPGEETVAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_996 MEPGLWLLFGLTVTSAAGFVPCSQSGDAGRRGVSQAPTAARSEGDCEETVAGPGEETVAG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 PGEGTVAPTALQGPSPGSPGQEQAAEGAPEHHRSRRCTCFTYKDKECVYYCHLDIIWINT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_996 PGEGTVAPTALQGPSPGSPGQEQAAEGAPEHHRSRRCTCFTYKDKECVYYCHLDIIWINT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 PEQTVPYGLSNYRGSFRGKRSAGPLPGNLQLSHRPHLRCACVGRYDKACLHFCTQTLDVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_996 PEQTVPYGLSNYRGSFRGKRSAGPLPGNLQLSHRPHLRCACVGRYDKACLHFCTQTLDVS 130 140 150 160 170 180 190 200 210 220 230 pF1KB6 SNSRTAEKTDKEEEGKVEVKDQQSKQALDLHHPKLMPGSGLALAPSTCPRCLFQEGAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_996 SNSRTAEKTDKEEEGKVEVKDQQSKQALDLHHPKLMPGSGLALAPSTCPRCLFQEGAP 190 200 210 220 230 >>XP_011526957 (OMIM: 131242,209880,613265,613712) PREDI (244 aa) initn: 1657 init1: 1292 opt: 1581 Z-score: 1413.0 bits: 268.9 E(85289): 5.7e-72 Smith-Waterman score: 1581; 92.6% identity (95.5% similar) in 244 aa overlap (1-238:1-244) 10 20 30 40 50 60 pF1KB6 MEPGLWLLFGLTVTSAAGFVPCSQSGDAGRRGVSQAPTAARSEGDCEETVAGPGEETVAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MEPGLWLLFGLTVTSAAGFVPCSQSGDAGRRGVSQAPTAARSEGDCEETVAGPGEETVAG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 PGEGTVAPTALQGPSPGSPGQEQAAEGAPEHHRSRRCTCFTYKDKECVYYCHLDIIWINT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PGEGTVAPTALQGPSPGSPGQEQAAEGAPEHHRSRRCTCFTYKDKECVYYCHLDIIWINT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 PEQTVPYGLSNYRGSFRGKRSAGPLPGNLQLSHRPHLRCACVGRYDKACLHFCTQTLDVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PEQTVPYGLSNYRGSFRGKRSAGPLPGNLQLSHRPHLRCACVGRYDKACLHFCTQTLDVS 130 140 150 160 170 180 190 200 210 220 230 pF1KB6 SN------SRTAEKTDKEEEGKVEVKDQQSKQALDLHHPKLMPGSGLALAPSTCPRCLFQ :. .: ..: :.. .:::::::::::::::::::::::::::::::::::::: XP_011 SSLPTVIQGRQKKQTKKRKGRQVEVKDQQSKQALDLHHPKLMPGSGLALAPSTCPRCLFQ 190 200 210 220 230 240 pF1KB6 EGAP :::: XP_011 EGAP >>XP_006723797 (OMIM: 131242,209880,613265,613712) PREDI (208 aa) initn: 1388 init1: 1388 opt: 1388 Z-score: 1243.3 bits: 237.2 E(85289): 1.6e-62 Smith-Waterman score: 1388; 100.0% identity (100.0% similar) in 197 aa overlap (1-197:1-197) 10 20 30 40 50 60 pF1KB6 MEPGLWLLFGLTVTSAAGFVPCSQSGDAGRRGVSQAPTAARSEGDCEETVAGPGEETVAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MEPGLWLLFGLTVTSAAGFVPCSQSGDAGRRGVSQAPTAARSEGDCEETVAGPGEETVAG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 PGEGTVAPTALQGPSPGSPGQEQAAEGAPEHHRSRRCTCFTYKDKECVYYCHLDIIWINT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 PGEGTVAPTALQGPSPGSPGQEQAAEGAPEHHRSRRCTCFTYKDKECVYYCHLDIIWINT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 PEQTVPYGLSNYRGSFRGKRSAGPLPGNLQLSHRPHLRCACVGRYDKACLHFCTQTLDVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 PEQTVPYGLSNYRGSFRGKRSAGPLPGNLQLSHRPHLRCACVGRYDKACLHFCTQTLDVS 130 140 150 160 170 180 190 200 210 220 230 pF1KB6 SNSRTAEKTDKEEEGKVEVKDQQSKQALDLHHPKLMPGSGLALAPSTCPRCLFQEGAP ::::::::::::::::: XP_006 SNSRTAEKTDKEEEGKVRGANRGLCQRR 190 200 >>NP_996915 (OMIM: 131242,209880,613265,613712) endothel (219 aa) initn: 1388 init1: 1388 opt: 1388 Z-score: 1243.0 bits: 237.2 E(85289): 1.7e-62 Smith-Waterman score: 1388; 100.0% identity (100.0% similar) in 197 aa overlap (1-197:1-197) 10 20 30 40 50 60 pF1KB6 MEPGLWLLFGLTVTSAAGFVPCSQSGDAGRRGVSQAPTAARSEGDCEETVAGPGEETVAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_996 MEPGLWLLFGLTVTSAAGFVPCSQSGDAGRRGVSQAPTAARSEGDCEETVAGPGEETVAG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 PGEGTVAPTALQGPSPGSPGQEQAAEGAPEHHRSRRCTCFTYKDKECVYYCHLDIIWINT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_996 PGEGTVAPTALQGPSPGSPGQEQAAEGAPEHHRSRRCTCFTYKDKECVYYCHLDIIWINT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 PEQTVPYGLSNYRGSFRGKRSAGPLPGNLQLSHRPHLRCACVGRYDKACLHFCTQTLDVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_996 PEQTVPYGLSNYRGSFRGKRSAGPLPGNLQLSHRPHLRCACVGRYDKACLHFCTQTLDVS 130 140 150 160 170 180 190 200 210 220 230 pF1KB6 SNSRTAEKTDKEEEGKVEVKDQQSKQALDLHHPKLMPGSGLALAPSTCPRCLFQEGAP ::::::::::::::::: NP_996 SNSRTAEKTDKEEEGKVRGANRGLCQRRLKSRTNKASRL 190 200 210 >>XP_005260369 (OMIM: 131242,209880,613265,613712) PREDI (251 aa) initn: 1388 init1: 1388 opt: 1388 Z-score: 1242.2 bits: 237.3 E(85289): 1.9e-62 Smith-Waterman score: 1643; 94.8% identity (94.8% similar) in 251 aa overlap (1-238:1-251) 10 20 30 40 50 60 pF1KB6 MEPGLWLLFGLTVTSAAGFVPCSQSGDAGRRGVSQAPTAARSEGDCEETVAGPGEETVAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MEPGLWLLFGLTVTSAAGFVPCSQSGDAGRRGVSQAPTAARSEGDCEETVAGPGEETVAG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 PGEGTVAPTALQGPSPGSPGQEQAAEGAPEHHRSRRCTCFTYKDKECVYYCHLDIIWINT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PGEGTVAPTALQGPSPGSPGQEQAAEGAPEHHRSRRCTCFTYKDKECVYYCHLDIIWINT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 PEQTVPYGLSNYRGSFRGKRSAGPLPGNLQLSHRPHLRCACVGRYDKACLHFCTQTLDVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PEQTVPYGLSNYRGSFRGKRSAGPLPGNLQLSHRPHLRCACVGRYDKACLHFCTQTLDVS 130 140 150 160 170 180 190 200 210 220 pF1KB6 SNSRTAEKTDKEEEGKV-------------EVKDQQSKQALDLHHPKLMPGSGLALAPST ::::::::::::::::: :::::::::::::::::::::::::::::: XP_005 SNSRTAEKTDKEEEGKVRGANRGLCQRRQVEVKDQQSKQALDLHHPKLMPGSGLALAPST 190 200 210 220 230 240 230 pF1KB6 CPRCLFQEGAP ::::::::::: XP_005 CPRCLFQEGAP 250 >>NP_001289384 (OMIM: 131242,209880,613265,613712) endot (198 aa) initn: 1383 init1: 1383 opt: 1383 Z-score: 1239.1 bits: 236.4 E(85289): 2.8e-62 Smith-Waterman score: 1383; 100.0% identity (100.0% similar) in 196 aa overlap (1-196:1-196) 10 20 30 40 50 60 pF1KB6 MEPGLWLLFGLTVTSAAGFVPCSQSGDAGRRGVSQAPTAARSEGDCEETVAGPGEETVAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MEPGLWLLFGLTVTSAAGFVPCSQSGDAGRRGVSQAPTAARSEGDCEETVAGPGEETVAG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 PGEGTVAPTALQGPSPGSPGQEQAAEGAPEHHRSRRCTCFTYKDKECVYYCHLDIIWINT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PGEGTVAPTALQGPSPGSPGQEQAAEGAPEHHRSRRCTCFTYKDKECVYYCHLDIIWINT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 PEQTVPYGLSNYRGSFRGKRSAGPLPGNLQLSHRPHLRCACVGRYDKACLHFCTQTLDVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PEQTVPYGLSNYRGSFRGKRSAGPLPGNLQLSHRPHLRCACVGRYDKACLHFCTQTLDVS 130 140 150 160 170 180 190 200 210 220 230 pF1KB6 SNSRTAEKTDKEEEGKVEVKDQQSKQALDLHHPKLMPGSGLALAPSTCPRCLFQEGAP :::::::::::::::: NP_001 SNSRTAEKTDKEEEGKTG 190 >>XP_005260370 (OMIM: 131242,209880,613265,613712) PREDI (212 aa) initn: 1432 init1: 1292 opt: 1301 Z-score: 1166.2 bits: 223.0 E(85289): 3.2e-58 Smith-Waterman score: 1301; 87.7% identity (94.8% similar) in 211 aa overlap (1-206:1-211) 10 20 30 40 50 60 pF1KB6 MEPGLWLLFGLTVTSAAGFVPCSQSGDAGRRGVSQAPTAARSEGDCEETVAGPGEETVAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MEPGLWLLFGLTVTSAAGFVPCSQSGDAGRRGVSQAPTAARSEGDCEETVAGPGEETVAG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 PGEGTVAPTALQGPSPGSPGQEQAAEGAPEHHRSRRCTCFTYKDKECVYYCHLDIIWINT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PGEGTVAPTALQGPSPGSPGQEQAAEGAPEHHRSRRCTCFTYKDKECVYYCHLDIIWINT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 PEQTVPYGLSNYRGSFRGKRSAGPLPGNLQLSHRPHLRCACVGRYDKACLHFCTQTLDVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PEQTVPYGLSNYRGSFRGKRSAGPLPGNLQLSHRPHLRCACVGRYDKACLHFCTQTLDVS 130 140 150 160 170 180 190 200 210 220 230 pF1KB6 SNSRTA-----EKTDKEEEGKVEVKDQQSKQALDLHHPKLMPGSGLALAPSTCPRCLFQE :. :. .: :...:... . ..... XP_005 SSLPTVIQGRQKKQTKKRKGRLKSRTNKASRL 190 200 210 pF1KB6 GAP >>NP_996916 (OMIM: 131242,209880,613265,613712) endothel (224 aa) initn: 1374 init1: 1293 opt: 1293 Z-score: 1158.8 bits: 221.7 E(85289): 8.3e-58 Smith-Waterman score: 1545; 93.3% identity (93.7% similar) in 238 aa overlap (1-238:1-224) 10 20 30 40 50 60 pF1KB6 MEPGLWLLFGLTVTSAAGFVPCSQSGDAGRRGVSQAPTAARSEGDCEETVAGPGEETVAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_996 MEPGLWLLFGLTVTSAAGFVPCSQSGDAGRRGVSQAPTAARSEGDCEETVAGPGEETVAG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 PGEGTVAPTALQGPSPGSPGQEQAAEGAPEHHRSRRCTCFTYKDKECVYYCHLDIIWINT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_996 PGEGTVAPTALQGPSPGSPGQEQAAEGAPEHHRSRRCTCFTYKDKECVYYCHLDIIWINT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 PEQTVPYGLSNYRGSFRGKRSAGPLPGNLQLSHRPHLRCACVGRYDKACLHFCTQTLDVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_996 PEQTVPYGLSNYRGSFRGKRSAGPLPGNLQLSHRPHLRCACVGRYDKACLHFCTQTLDVS 130 140 150 160 170 180 190 200 210 220 230 pF1KB6 SNSRTAEKTDKEEEGKVEVKDQQSKQALDLHHPKLMPGSGLALAPSTCPRCLFQEGAP .:::::::::::::::::::::::::::::::::::::::::: NP_996 R--------------QVEVKDQQSKQALDLHHPKLMPGSGLALAPSTCPRCLFQEGAP 190 200 210 220 >>NP_001289385 (OMIM: 131242,209880,613265,613712) endot (192 aa) initn: 1286 init1: 1286 opt: 1291 Z-score: 1157.9 bits: 221.3 E(85289): 9.3e-58 Smith-Waterman score: 1291; 96.3% identity (97.9% similar) in 190 aa overlap (1-189:1-190) 10 20 30 40 50 60 pF1KB6 MEPGLWLLFGLTVTSAAGFVPCSQSGDAGRRGVSQAPTAARSEGDCEETVAGPGEETVAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MEPGLWLLFGLTVTSAAGFVPCSQSGDAGRRGVSQAPTAARSEGDCEETVAGPGEETVAG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 PGEGTVAPTALQGPSPGSPGQEQAAEGAPEHHRSRRCTCFTYKDKECVYYCHLDIIWINT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PGEGTVAPTALQGPSPGSPGQEQAAEGAPEHHRSRRCTCFTYKDKECVYYCHLDIIWINT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 PEQTVPYGLSNYRGSFRGKRSAGPLPGNLQLSHRPHLRCACVGRYDKACLHFCTQTLDVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PEQTVPYGLSNYRGSFRGKRSAGPLPGNLQLSHRPHLRCACVGRYDKACLHFCTQTLDVS 130 140 150 160 170 180 190 200 210 220 230 pF1KB6 S-NSRTAEKTDKEEEGKVEVKDQQSKQALDLHHPKLMPGSGLALAPSTCPRCLFQEGAP .::: . . NP_001 RLKSRTNKASRL 190 >>XP_011512632 (OMIM: 131240,612798,615706) PREDICTED: e (212 aa) initn: 320 init1: 231 opt: 314 Z-score: 293.2 bits: 61.5 E(85289): 1.4e-09 Smith-Waterman score: 314; 37.6% identity (63.8% similar) in 141 aa overlap (58-196:13-146) 30 40 50 60 70 80 pF1KB6 AGRRGVSQAPTAARSEGDCEETVAGPGEETVAGPGEGTVAPTALQGPSPGSPGQEQAAEG :: : .: . . . : : :. . . XP_011 MDYLLMIFSLLFVACQGAPETAVLGAELSAVGENGGEKPTPS 10 20 30 40 90 100 110 120 130 140 pF1KB6 APEH-HRSRRCTCFTYKDKECVYYCHLDIIWINTPEQTVPYGLSNYRGSFRGKRS-AGPL : . .::.::.: . ::::::.:::::::.::::..::::: :: :.::. . : XP_011 PPWRLRRSKRCSCSSLMDKECVYFCHLDIIWVNTPEHVVPYGL----GSPRSKRALENLL 50 60 70 80 90 150 160 170 180 190 200 pF1KB6 PGNLQLSHRPHLRCACVGRYDKACLHFCTQTLDVSSNSRTAEKTDKEEEGKVEVKDQQSK : . . : . :: :... :: : .:: .. ... . .....:: XP_011 P--TKATDREN-RCQCASQKDKKCWNFCQAGKELRAEDIMEKDWNNHKKGKDCSKLGKKC 100 110 120 130 140 150 210 220 230 pF1KB6 QALDLHHPKLMPGSGLALAPSTCPRCLFQEGAP XP_011 IYQQLVRGRKIRRSSEEHLRQTRSETMRNSVKSSFHDPKLKGKPSRERYVTHNRAHW 160 170 180 190 200 210 238 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 13:02:20 2016 done: Sun Nov 6 13:02:21 2016 Total Scan time: 7.470 Total Display time: 0.010 Function used was FASTA [36.3.4 Apr, 2011]