FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE4128, 526 aa 1>>>pF1KE4128 526 - 526 aa - 526 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.4849+/-0.000369; mu= 17.3812+/- 0.023 mean_var=87.4075+/-18.261, 0's: 0 Z-trim(115.5): 186 B-trim: 218 in 1/49 Lambda= 0.137183 statistics sampled from 25773 (26041) to 25773 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.68), E-opt: 0.2 (0.305), width: 16 Scan time: 10.630 The best scores are: opt bits E(85289) NP_002242 (OMIM: 602905) potassium voltage-gated c ( 526) 3519 706.8 3.9e-203 NP_001309728 (OMIM: 602905) potassium voltage-gate ( 526) 3519 706.8 3.9e-203 XP_016883335 (OMIM: 602905) PREDICTED: potassium v ( 527) 3358 675.0 1.5e-193 NP_065748 (OMIM: 602906) potassium voltage-gated c ( 477) 945 197.4 8.2e-50 NP_579875 (OMIM: 606767) potassium voltage-gated c ( 436) 878 184.1 7.5e-46 NP_000208 (OMIM: 160120,176260) potassium voltage- ( 495) 733 155.4 3.6e-37 NP_005540 (OMIM: 602420) potassium voltage-gated c ( 511) 688 146.5 1.8e-34 NP_055194 (OMIM: 608164) potassium voltage-gated c ( 500) 686 146.1 2.3e-34 XP_016869471 (OMIM: 607738) PREDICTED: potassium v ( 666) 652 139.5 3e-32 XP_016869470 (OMIM: 607738) PREDICTED: potassium v ( 666) 652 139.5 3e-32 XP_016859548 (OMIM: 603888) PREDICTED: potassium v ( 491) 642 137.4 9.5e-32 NP_002243 (OMIM: 603888) potassium voltage-gated c ( 491) 642 137.4 9.5e-32 XP_011531127 (OMIM: 603888) PREDICTED: potassium v ( 491) 642 137.4 9.5e-32 NP_001269357 (OMIM: 603888) potassium voltage-gate ( 491) 642 137.4 9.5e-32 NP_114092 (OMIM: 176268) potassium voltage-gated c ( 456) 628 134.6 6.1e-31 NP_002223 (OMIM: 176263) potassium voltage-gated c ( 575) 629 134.9 6.3e-31 XP_011539698 (OMIM: 176262,616366) PREDICTED: pota ( 499) 622 133.5 1.5e-30 XP_011539699 (OMIM: 176262,616366) PREDICTED: pota ( 499) 622 133.5 1.5e-30 XP_016856702 (OMIM: 176262,616366) PREDICTED: pota ( 499) 622 133.5 1.5e-30 NP_004965 (OMIM: 176262,616366) potassium voltage- ( 499) 622 133.5 1.5e-30 XP_011539700 (OMIM: 176262,616366) PREDICTED: pota ( 499) 622 133.5 1.5e-30 XP_011539702 (OMIM: 176262,616366) PREDICTED: pota ( 499) 622 133.5 1.5e-30 XP_011539701 (OMIM: 176262,616366) PREDICTED: pota ( 499) 622 133.5 1.5e-30 NP_002225 (OMIM: 176267,612240) potassium voltage- ( 613) 618 132.7 3e-30 NP_002227 (OMIM: 603787) potassium voltage-gated c ( 494) 614 131.9 4.4e-30 XP_011524220 (OMIM: 605696) PREDICTED: potassium v ( 466) 610 131.1 7.3e-30 XP_016881194 (OMIM: 605696) PREDICTED: potassium v ( 466) 610 131.1 7.3e-30 NP_036415 (OMIM: 605696) potassium voltage-gated c ( 466) 610 131.1 7.3e-30 XP_011524222 (OMIM: 605696) PREDICTED: potassium v ( 466) 610 131.1 7.3e-30 XP_016881193 (OMIM: 605696) PREDICTED: potassium v ( 509) 610 131.1 7.8e-30 NP_002224 (OMIM: 176266) potassium voltage-gated c ( 653) 610 131.2 9.5e-30 NP_758847 (OMIM: 606767) potassium voltage-gated c ( 425) 570 123.1 1.7e-27 NP_036413 (OMIM: 605410) potassium voltage-gated c ( 630) 512 111.8 6.4e-24 XP_016884997 (OMIM: 300281) PREDICTED: potassium v ( 558) 495 108.4 6e-23 XP_016884998 (OMIM: 300281) PREDICTED: potassium v ( 558) 495 108.4 6e-23 NP_004970 (OMIM: 300281) potassium voltage-gated c ( 647) 495 108.4 6.7e-23 XP_011542212 (OMIM: 300281) PREDICTED: potassium v ( 647) 495 108.4 6.7e-23 XP_006710694 (OMIM: 605411,607346,616399) PREDICTE ( 510) 490 107.3 1.1e-22 XP_006710693 (OMIM: 605411,607346,616399) PREDICTE ( 636) 490 107.4 1.3e-22 NP_751948 (OMIM: 605411,607346,616399) potassium v ( 636) 490 107.4 1.3e-22 XP_016856733 (OMIM: 605411,607346,616399) PREDICTE ( 655) 490 107.4 1.3e-22 NP_004971 (OMIM: 605411,607346,616399) potassium v ( 655) 490 107.4 1.3e-22 XP_006710692 (OMIM: 605411,607346,616399) PREDICTE ( 655) 490 107.4 1.3e-22 XP_005270908 (OMIM: 605411,607346,616399) PREDICTE ( 655) 490 107.4 1.3e-22 XP_011519257 (OMIM: 176257) PREDICTED: potassium v ( 529) 480 105.4 4.5e-22 XP_016874759 (OMIM: 176257) PREDICTED: potassium v ( 529) 480 105.4 4.5e-22 NP_002226 (OMIM: 176257) potassium voltage-gated c ( 529) 480 105.4 4.5e-22 XP_016874760 (OMIM: 176257) PREDICTED: potassium v ( 529) 480 105.4 4.5e-22 XP_016874761 (OMIM: 176257) PREDICTED: potassium v ( 529) 480 105.4 4.5e-22 XP_005253743 (OMIM: 176257) PREDICTED: potassium v ( 529) 480 105.4 4.5e-22 >>NP_002242 (OMIM: 602905) potassium voltage-gated chann (526 aa) initn: 3519 init1: 3519 opt: 3519 Z-score: 3767.9 bits: 706.8 E(85289): 3.9e-203 Smith-Waterman score: 3519; 99.8% identity (100.0% similar) in 526 aa overlap (1-526:1-526) 10 20 30 40 50 60 pF1KE4 MLMLLVRGTHYENLRSKVVLPTPLGGRSTETFVSEFPGPDTGIRWRRSDEALRVNVGGVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 MLMLLVRGTHYENLRSKVVLPTPLGGRSTETFVSEFPGPDTGIRWRRSDEALRVNVGGVR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 RQLSARALARFPGTRLGRLQAAASEEQARRLCDDYDEAAREFYFDRHPGFFLSLLHFYRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 RQLSARALARFPGTRLGRLQAAASEEQARRLCDDYDEAAREFYFDRHPGFFLSLLHFYRT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 GHLHVLDELCVFAFGQEADYWGLGENALAACCRARYLERRLTQPHAWDEDSDTPSSVDPC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 GHLHVLDELCVFAFGQEADYWGLGENALAACCRARYLERRLTQPHAWDEDSDTPSSVDPC 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 PDEISDVQRELARYGAARCGRLRRRLWLTMENPGYSLPSKLFSCVSISVVLASIAAMCIH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 PDEISDVQRELARYGAARCGRLRRRLWLTMENPGYSLPSKLFSCVSISVVLASIAAMCIH 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 SLPEYQAREAAAAVAAVAAGRSPEGVRDDPVLRRLEYFCIAWFSFEVSSRLLLAPSTRNF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 SLPEYQAREAAAAVAAVAAGRSPEGVRDDPVLRRLEYFCIAWFSFEVSSRLLLAPSTRNF 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 FCHPLNLIDIVSVLPFYLTLLAGVALGDQGGKEFGHLGKVVQVFRLMRIFRVLKLARHST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 FCHPLNLIDIVSVLPFYLTLLAGVALGDQGGKEFGHLGKVVQVFRLMRIFRVLKLARHST 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 GLRSLGATLKHSYREVGILLLYLAVGVSVFSGVAYTAEKEEDVGFNTIPACWWWGTVSMT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 GLRSLGATLKHSYREVGILLLYLAVGVSVFSGVAYTAEKEEDVGFNTIPACWWWGTVSMT 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE4 TVGYGDVVPVTVAGKLAASGCILGGILVVALPITIIFNKFSHFYRRQKALEAAVRNSNHQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 TVGYGDVVPVTVAGKLAASGCILGGILVVALPITIIFNKFSHFYRRQKALEAAVRNSNHQ 430 440 450 460 470 480 490 500 510 520 pF1KE4 EFEDLLSSVDGVSEASLETSRETSQEGQSADLESQAPSEPPHPQMY ::::::::.::::::::::::::::::::::::::::::::::::: NP_002 EFEDLLSSIDGVSEASLETSRETSQEGQSADLESQAPSEPPHPQMY 490 500 510 520 >>NP_001309728 (OMIM: 602905) potassium voltage-gated ch (526 aa) initn: 3519 init1: 3519 opt: 3519 Z-score: 3767.9 bits: 706.8 E(85289): 3.9e-203 Smith-Waterman score: 3519; 99.8% identity (100.0% similar) in 526 aa overlap (1-526:1-526) 10 20 30 40 50 60 pF1KE4 MLMLLVRGTHYENLRSKVVLPTPLGGRSTETFVSEFPGPDTGIRWRRSDEALRVNVGGVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MLMLLVRGTHYENLRSKVVLPTPLGGRSTETFVSEFPGPDTGIRWRRSDEALRVNVGGVR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 RQLSARALARFPGTRLGRLQAAASEEQARRLCDDYDEAAREFYFDRHPGFFLSLLHFYRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RQLSARALARFPGTRLGRLQAAASEEQARRLCDDYDEAAREFYFDRHPGFFLSLLHFYRT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 GHLHVLDELCVFAFGQEADYWGLGENALAACCRARYLERRLTQPHAWDEDSDTPSSVDPC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GHLHVLDELCVFAFGQEADYWGLGENALAACCRARYLERRLTQPHAWDEDSDTPSSVDPC 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 PDEISDVQRELARYGAARCGRLRRRLWLTMENPGYSLPSKLFSCVSISVVLASIAAMCIH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PDEISDVQRELARYGAARCGRLRRRLWLTMENPGYSLPSKLFSCVSISVVLASIAAMCIH 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 SLPEYQAREAAAAVAAVAAGRSPEGVRDDPVLRRLEYFCIAWFSFEVSSRLLLAPSTRNF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SLPEYQAREAAAAVAAVAAGRSPEGVRDDPVLRRLEYFCIAWFSFEVSSRLLLAPSTRNF 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 FCHPLNLIDIVSVLPFYLTLLAGVALGDQGGKEFGHLGKVVQVFRLMRIFRVLKLARHST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FCHPLNLIDIVSVLPFYLTLLAGVALGDQGGKEFGHLGKVVQVFRLMRIFRVLKLARHST 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 GLRSLGATLKHSYREVGILLLYLAVGVSVFSGVAYTAEKEEDVGFNTIPACWWWGTVSMT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GLRSLGATLKHSYREVGILLLYLAVGVSVFSGVAYTAEKEEDVGFNTIPACWWWGTVSMT 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE4 TVGYGDVVPVTVAGKLAASGCILGGILVVALPITIIFNKFSHFYRRQKALEAAVRNSNHQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TVGYGDVVPVTVAGKLAASGCILGGILVVALPITIIFNKFSHFYRRQKALEAAVRNSNHQ 430 440 450 460 470 480 490 500 510 520 pF1KE4 EFEDLLSSVDGVSEASLETSRETSQEGQSADLESQAPSEPPHPQMY ::::::::.::::::::::::::::::::::::::::::::::::: NP_001 EFEDLLSSIDGVSEASLETSRETSQEGQSADLESQAPSEPPHPQMY 490 500 510 520 >>XP_016883335 (OMIM: 602905) PREDICTED: potassium volta (527 aa) initn: 3358 init1: 3358 opt: 3358 Z-score: 3595.6 bits: 675.0 E(85289): 1.5e-193 Smith-Waterman score: 3358; 99.8% identity (100.0% similar) in 501 aa overlap (26-526:27-527) 10 20 30 40 50 pF1KE4 MLMLLVRGTHYENLRSKVVLPTPLGGRSTETFVSEFPGPDTGIRWRRSDEALRVNVGGV :::::::::::::::::::::::::::::::::: XP_016 MEEGILTWSSRKGSPGTPQRALLVSAGRSTETFVSEFPGPDTGIRWRRSDEALRVNVGGV 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE4 RRQLSARALARFPGTRLGRLQAAASEEQARRLCDDYDEAAREFYFDRHPGFFLSLLHFYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RRQLSARALARFPGTRLGRLQAAASEEQARRLCDDYDEAAREFYFDRHPGFFLSLLHFYR 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE4 TGHLHVLDELCVFAFGQEADYWGLGENALAACCRARYLERRLTQPHAWDEDSDTPSSVDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TGHLHVLDELCVFAFGQEADYWGLGENALAACCRARYLERRLTQPHAWDEDSDTPSSVDP 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE4 CPDEISDVQRELARYGAARCGRLRRRLWLTMENPGYSLPSKLFSCVSISVVLASIAAMCI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CPDEISDVQRELARYGAARCGRLRRRLWLTMENPGYSLPSKLFSCVSISVVLASIAAMCI 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE4 HSLPEYQAREAAAAVAAVAAGRSPEGVRDDPVLRRLEYFCIAWFSFEVSSRLLLAPSTRN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HSLPEYQAREAAAAVAAVAAGRSPEGVRDDPVLRRLEYFCIAWFSFEVSSRLLLAPSTRN 250 260 270 280 290 300 300 310 320 330 340 350 pF1KE4 FFCHPLNLIDIVSVLPFYLTLLAGVALGDQGGKEFGHLGKVVQVFRLMRIFRVLKLARHS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FFCHPLNLIDIVSVLPFYLTLLAGVALGDQGGKEFGHLGKVVQVFRLMRIFRVLKLARHS 310 320 330 340 350 360 360 370 380 390 400 410 pF1KE4 TGLRSLGATLKHSYREVGILLLYLAVGVSVFSGVAYTAEKEEDVGFNTIPACWWWGTVSM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TGLRSLGATLKHSYREVGILLLYLAVGVSVFSGVAYTAEKEEDVGFNTIPACWWWGTVSM 370 380 390 400 410 420 420 430 440 450 460 470 pF1KE4 TTVGYGDVVPVTVAGKLAASGCILGGILVVALPITIIFNKFSHFYRRQKALEAAVRNSNH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TTVGYGDVVPVTVAGKLAASGCILGGILVVALPITIIFNKFSHFYRRQKALEAAVRNSNH 430 440 450 460 470 480 480 490 500 510 520 pF1KE4 QEFEDLLSSVDGVSEASLETSRETSQEGQSADLESQAPSEPPHPQMY :::::::::.::::::::::::::::::::::::::::::::::::: XP_016 QEFEDLLSSIDGVSEASLETSRETSQEGQSADLESQAPSEPPHPQMY 490 500 510 520 >>NP_065748 (OMIM: 602906) potassium voltage-gated chann (477 aa) initn: 1536 init1: 752 opt: 945 Z-score: 1015.3 bits: 197.4 E(85289): 8.2e-50 Smith-Waterman score: 1562; 51.5% identity (77.5% similar) in 472 aa overlap (49-519:16-469) 20 30 40 50 60 70 pF1KE4 VLPTPLGGRSTETFVSEFPGPDTGIRWRRSDEALRVNVGGVRRQLSARALARFPGTRLGR : .:.:::: .:.: ...: ::: ::::: NP_065 MTGQSLWDVSEANVEDGEIRINVGGFKRRLRSHTLLRFPETRLGR 10 20 30 40 80 90 100 110 120 130 pF1KE4 LQAAASEEQARRLCDDYDEAAREFYFDRHPGFFLSLLHFYRTGHLHVLDELCVFAFGQEA : :.: .::::::.. :::::::.: .: .::::.::.:::. :::::.:.:: NP_065 LLLCHSREAILELCDDYDDVQREFYFDRNPELFPYVLHFYHTGKLHVMAELCVFSFSQEI 50 60 70 80 90 100 140 150 160 170 180 190 pF1KE4 DYWGLGENALAACCRARYLERRLT-QPHAWDEDSDTPSSVDPCPDEISDVQRELARYGAA .:::..: . .:: : :.. . . :::.:: :... ::: . ... . NP_065 EYWGINEFFIDSCCSYSYHGRKVEPEQEKWDEQSDQESTTSSF-DEILAFYNDASKFDGQ 110 120 130 140 150 160 200 210 220 230 240 250 pF1KE4 RCGRLRRRLWLTMENPGYSLPSKLFSCVSISVVLASIAAMCIHSLPEYQAREAAAAVAAV : .::.:::...:::::. :..:: .:: ::..:: .::..:::..: .. . NP_065 PLGNFRRQLWLALDNPGYSVLSRVFSILSILVVMGSIITMCLNSLPDFQIPDSQG----- 170 180 190 200 210 260 270 280 290 300 310 pF1KE4 AAGRSPEGVRDDPVLRRLEYFCIAWFSFEVSSRLLLAPSTRNFFCHPLNLIDIVSVLPFY .: : .:: .. .:.: ::::.::. .:. .::. .:: . :::::..:..::: NP_065 ----NP-G--EDPRFEIVEHFGIAWFTFELVARFAVAPDFLKFFKNALNLIDLMSIVPFY 220 230 240 250 260 270 320 330 340 350 360 370 pF1KE4 LTLLAGVALGDQGGKEFGHLGKVVQVFRLMRIFRVLKLARHSTGLRSLGATLKHSYREVG .::...... .. ...::.:.::.:::::::.::::::::::::::::::.::.::: NP_065 ITLVVNLVV--ESTPTLANLGRVAQVLRLMRIFRILKLARHSTGLRSLGATLKYSYKEVG 280 290 300 310 320 330 380 390 400 410 420 430 pF1KE4 ILLLYLAVGVSVFSGVAYTAEKEEDVGFNTIPACWWWGTVSMTTVGYGDVVPVTVAGKLA .:::::.::.:.:: :::: ::::. :. ::::::::.:::::::::::::: :.::::. NP_065 LLLLYLSVGISIFSVVAYTIEKEENEGLATIPACWWWATVSMTTVGYGDVVPGTTAGKLT 340 350 360 370 380 390 440 450 460 470 480 490 pF1KE4 ASGCILGGILVVALPITIIFNKFSHFYRRQKALEAAVRNSNHQEFEDLLSSVDGVSEASL ::.:::.:::::.::::.::::::::::::: ::.:.:. . : : .. : .:. . NP_065 ASACILAGILVVVLPITLIFNKFSHFYRRQKQLESAMRSCD---FGDGMKEVPSVNLRDY 400 410 420 430 440 500 510 520 pF1KE4 ETSRETSQEGQSADLESQAPSEPPHPQMY . . : .. ... ..::: NP_065 YAHKVKSLMASLTNMSRSSPSELSLNDSLR 450 460 470 >>NP_579875 (OMIM: 606767) potassium voltage-gated chann (436 aa) initn: 751 init1: 239 opt: 878 Z-score: 944.1 bits: 184.1 E(85289): 7.5e-46 Smith-Waterman score: 878; 35.5% identity (64.8% similar) in 454 aa overlap (46-482:5-434) 20 30 40 50 60 70 pF1KE4 SKVVLPTPLGGRSTETFVSEFPGPDTGIRWRRSDEALRVNVGGVRRQLSARALARFPGTR : . .. .::::.: .:: . : :: : NP_579 MTFGRSGAASVVLNVGGARYSLSRELLKDFPLRR 10 20 30 80 90 100 110 120 130 pF1KE4 LGRLQAAASEEQARRLCDDYDEAAREFYFDRHPGFFLSLLHFYRT-GHLHVLDELCVFAF ..::.. ::... ..:::::. :..:::: : .: . : :.:. ..: ..: NP_579 VSRLHGCRSERDVLEVCDDYDRERNEYFFDRHSEAFGFILLYVRGHGKLRFAPRMCELSF 40 50 60 70 80 90 140 150 160 170 180 190 pF1KE4 GQEADYWGLGENALAACCRARYLERRLTQPHAWDEDSDTPSSVDPCPDEISDVQRELARY .: :::: : :: .::: :. ::: . . :: . . :. :: NP_579 YNEMIYWGLEGAHLEYCC-----QRRLD-----DRMSDTYTFYS--ADEPGVLGRDEARP 100 110 120 130 140 200 210 220 230 240 250 pF1KE4 GAARCGRLRR---RLWLTMENPGYSLPSKLFSCVSISVVLASIAAMCIHSLPEYQAREAA :.:. . :: :. :.:.: :: ..... ::. :..:....: .::.. :.:: NP_579 GGAEAAPSRRWLERMRRTFEEPTSSLAAQILASVSVVFVIVSMVVLCASTLPDW--RNAA 150 160 170 180 190 200 260 270 280 290 300 pF1KE4 A--------AVAAVAAGRSPEGVRDDPVLRRLEYFCIAWFSFEVSSRLLLAPSTRNFFCH : . ... :: : :. .: .::.::. : :.... . .: . NP_579 ADNRSLDDRSRYSAGPGREPSGI--------IEAICIGWFTAECIVRFIVSKNKCEFVKR 210 220 230 240 250 310 320 330 340 350 360 pF1KE4 PLNLIDIVSVLPFYLTLLAGVALGDQGGKEFGHLGKVVQVFRLMRIFRVLKLARHSTGLR :::.::.... :.:...: : :... .. . : ...:.:.:::: :.::::: ::. NP_579 PLNIIDLLAITPYYISVLMTVFTGENS--QLQRAGVTLRVLRMMRIFWVIKLARHFIGLQ 260 270 280 290 300 310 370 380 390 400 410 pF1KE4 SLGATLKHSYREVGILLLYLAVGVSVFSGVAYTAEKEEDV-----GFNTIPACWWWGTVS .:: :::. :::. .::... :....::... :. :. :..::: :: .: NP_579 TLGLTLKRCYREMVMLLVFICVAMAIFSALSQLLEHGLDLETSNKDFTSIPAACWWVIIS 320 330 340 350 360 370 420 430 440 450 460 470 pF1KE4 MTTVGYGDVVPVTVAGKLAASGCILGGILVVALPITIIFNKFSHFYRRQKALEAAVRNSN ::::::::. :.:: :.. .. :...::...:::::.:...: . :.. : : : NP_579 MTTVGYGDMYPITVPGRILGGVCVVSGIVLLALPITFIYHSFVQCYHELKFRSARYSRSL 380 390 400 410 420 430 480 490 500 510 520 pF1KE4 HQEFEDLLSSVDGVSEASLETSRETSQEGQSADLESQAPSEPPHPQMY :: NP_579 STEFLN >>NP_000208 (OMIM: 160120,176260) potassium voltage-gate (495 aa) initn: 778 init1: 251 opt: 733 Z-score: 788.3 bits: 155.4 E(85289): 3.6e-37 Smith-Waterman score: 810; 31.6% identity (63.4% similar) in 500 aa overlap (22-506:2-456) 10 20 30 40 50 pF1KE4 MLMLLVRGTHYENLRSKVVLPTPLGGRSTETFVSEFPG-PDTGIRWRRSD-------EAL : ..:.... .: :: :. : :..: : . NP_000 MTVMSGENVDE-ASAAPGHPQDGSYPRQADHDDHECCERV 10 20 30 60 70 80 90 100 110 pF1KE4 RVNVGGVRRQLSARALARFPGTRLGRLQAAASEEQARRLCDDYDEAAREFYFDRHPGFFL .:..:.: . . ..::.::.: :: ... : .: :..:::. : NP_000 VINISGLRFETQLKTLAQFPNTLLGN-----PKKRMRY----FDPLRNEYFFDRNRPSFD 40 50 60 70 80 90 120 130 140 150 160 170 pF1KE4 SLLHFYRTG-HLHVLDELCVFAFGQEADYWGLGENALAACCRARYLERRLTQPHAWDEDS ..:..:..: .:. .. . :..: .. :::.:. ... . ... .. NP_000 AILYYYQSGGRLRRPVNVPLDMFSEEIKFYELGEEAM----------EKFREDEGFIKEE 100 110 120 130 140 180 190 200 210 220 230 pF1KE4 DTPSSVDPCPDEISDVQRELARYGAARCGRLRRRLWLTMENPGYSLPSKLFSCVSISVVL . : :.. . .:..:: .: : : :..... ::. :.: NP_000 ERP-----LPEK-----------------EYQRQVWLLFEYPESSGPARVIAIVSVMVIL 150 160 170 240 250 260 270 280 pF1KE4 ASIAAMCIHSLPEYQA-REAAAAVAAVAAGRS--PEGVRDDPVLRRLEYFCIAWFSFEVS ::. .:...::: . .. ...: . .. :: . .: .:: :::::. NP_000 ISIVIFCLETLPELKDDKDFTGTVHRIDNTTVIYNSNIFTDPFFI-VETLCIIWFSFELV 180 190 200 210 220 230 290 300 310 320 330 340 pF1KE4 SRLLLAPSTRNFFCHPLNLIDIVSVLPFYLTLLAGVAL--GDQGGKEFGHLGKVVQVFRL :.. :: .:: . .:.::::...:...:: . .: :.: :.. :. ...:.:: NP_000 VRFFACPSKTDFFKNIMNFIDIVAIIPYFITLGTEIAEQEGNQKGEQATSLA-ILRVIRL 240 250 260 270 280 290 350 360 370 380 390 400 pF1KE4 MRIFRVLKLARHSTGLRSLGATLKHSYREVGILLLYLAVGVSVFSGVAYTAEKEE-DVGF .:.::..::.::: ::. :: ::: :.::.:.:...: .:: .::...: :: :: . : NP_000 VRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEAEEAESHF 300 310 320 330 340 350 410 420 430 440 450 460 pF1KE4 NTIPACWWWGTVSMTTVGYGDVVPVTVAGKLAASGCILGGILVVALPITIIFNKFSHFYR ..:: .::..::::::::::. :::..::...: : ..:.:..:::. .: ..:..::. NP_000 SSIPDAFWWAVVSMTTVGYGDMYPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYH 360 370 380 390 400 410 470 480 490 500 510 520 pF1KE4 RQKALEAAVRNSNHQEFEDLLSSVDGVSEASLETSRETSQEGQSADLESQAPSEPPHPQM :. : .. : .: :. : ..: :. .: NP_000 RETEGEEQAQ-LLHVSSPNLASDSDLSRRSSSTMSKSEYMEIEEDMNNSIAHYRQVNIRT 420 430 440 450 460 470 pF1KE4 Y NP_000 ANCTTANQNCVNKSKLLTDV 480 490 >>NP_005540 (OMIM: 602420) potassium voltage-gated chann (511 aa) initn: 677 init1: 357 opt: 688 Z-score: 740.0 bits: 146.5 E(85289): 1.8e-34 Smith-Waterman score: 765; 29.7% identity (63.7% similar) in 474 aa overlap (37-504:74-501) 10 20 30 40 50 60 pF1KE4 RGTHYENLRSKVVLPTPLGGRSTETFVSEFPGPDTGIRWRRSDEALRVNVGGVRRQLSAR :::. . .... . .:..:.: . . : NP_005 SSFSNGKILISESTNHETAFSKLPGDYADPPGPEP-VVLNEGNQRVIINIAGLRFETQLR 50 60 70 80 90 100 70 80 90 100 110 120 pF1KE4 ALARFPGTRLGRLQAAASEEQARRLCDDYDEAAREFYFDRHPGFFLSLLHFYRTG-HLHV .:..:: : :: .. .:. . .: :..:::. : ..:..:..: ... NP_005 TLSQFPETLLG--------DREKRM-QFFDSMRNEYFFDRNRPSFDGILYYYQSGGKIRR 110 120 130 140 150 130 140 150 160 170 180 pF1KE4 LDELCVFAFGQEADYWGLGENALAACCRARYLERRLTQPHAWDEDSDTPSSVDPCPDEIS .. . :..: ... :: .:. .. . ... .: : .. : : NP_005 PANVPIDIFADEISFYELGSEAMD----------QFREDEGFIKD---PETLLPTND--- 160 170 180 190 190 200 210 220 230 240 pF1KE4 DVQRELARYGAARCGRLRRRLWLTMENPGYSLPSKLFSCVSISVVLASIAAMCIHSLPEY ..:..:: .: : : .. . ::. ::. ::. .:...:::. NP_005 ----------------IHRQFWLLFEYPESSSAARAVAVVSVLVVVISITIFCLETLPEF 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 QAREAAAAVAAVAAGRSP----EGVRDDPVLRRLEYFCIAWFSFEVSSRLLLAPSTRNFF . . .: . : . . :: . .: ::.::.::. :... :: .:: NP_005 REDRELKVVRDPNLNMSKTVLSQTMFTDPFFM-VESTCIVWFTFELVLRFVVCPSKTDFF 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 CHPLNLIDIVSVLPFYLTLLAGVALGDQGGKEFGHLGKVVQVFRLMRIFRVLKLARHSTG . .:.:::.:..:.. ::.. .. . . . . .....::.:.::..::.::: : NP_005 RNIMNIIDIISIIPYFATLITELVQETEPSAQQNMSLAILRIIRLVRVFRIFKLSRHSKG 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 LRSLGATLKHSYREVGILLLYLAVGVSVFSGVAYTAEKEE-DVGFNTIPACWWWGTVSMT :. :: ::: :.::.:.:...: .:: .::...: :: .: . :..:: .::..:.:: NP_005 LQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEVDEPESHFSSIPDGFWWAVVTMT 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE4 TVGYGDVVPVTVAGKLAASGCILGGILVVALPITIIFNKFSHFYRRQKALEAAVRNSNHQ ::::::. :.: .::.... : ..:.:..:::. .: ..:..::.:. : ... NP_005 TVGYGDMCPTTPGGKIVGTLCAIAGVLTIALPVPVIVSNFNYFYHRET--ENEEKQNIPG 430 440 450 460 470 490 500 510 520 pF1KE4 EFEDLLSSVDGVSEASLETSRETSQEGQSADLESQAPSEPPHPQMY :.: .:.:: : .: .. .:. NP_005 EIERILNSV-GSRMGSTDSLNKTNGGCSTEKSRK 480 490 500 510 >>NP_055194 (OMIM: 608164) potassium voltage-gated chann (500 aa) initn: 845 init1: 429 opt: 686 Z-score: 738.0 bits: 146.1 E(85289): 2.3e-34 Smith-Waterman score: 1061; 39.9% identity (64.9% similar) in 476 aa overlap (17-475:6-446) 10 20 30 40 50 pF1KE4 MLMLLVRGTHYENLRSKVVLPTPLGGRS-----TETFVSEFPGPDTGIRWRRSDEALRVN ...: .:: . : . .: :: : .. . . :: NP_055 MPSSGRALLDSPLDSGSLTSLDSSVFCSEGEGEPLAL-----GDCFTVN 10 20 30 40 60 70 80 90 100 pF1KE4 VGGVRRQLSARALARFPGTRLGRLQ----------AAASEEQARRLCDDYDEAAREFYFD ::: : :: .::. :: ::::.: : :. . .:::: . . :..:: NP_055 VGGSRFVLSQQALSCFPHTRLGKLAVVVASYRRPGALAAVPSPLELCDDANPVDNEYFFD 50 60 70 80 90 100 110 120 130 140 150 160 pF1KE4 RHPGFFLSLLHFYRTGHLHVLDELCVFAFGQEADYWGLGENALAACCRARYLERR-LTQP : : .::.::::.:::...::...: :: .:::. : .. .::: ::..:. :.. NP_055 RSSQAFRYVLHYYRTGRLHVMEQLCALSFLQEIQYWGIDELSIDSCCRDRYFRRKELSET 110 120 130 140 150 160 170 180 190 200 210 220 pF1KE4 HAWDEDSDTPSSVDPCPDEISDVQRELARYGAARCGRLRRRLWLTMENPGYSLPSKLFSC . .:.. :. :. . : .. . : .:..:: .:.:: : ...:. NP_055 LDFKKDTE---------DQESQHESE-QDFSQGPCPTVRQKLWNILEKPGSSTAARIFGV 170 180 190 200 210 230 240 250 260 270 280 pF1KE4 VSISVVLASIAAMCIHSLPEYQAREAAAAVAAVAAGRSPEGVRDDPVLRRLEYFCIAWFS .:: :..:: : . : : .. . : .:. ::: ::.::. NP_055 ISIIFVVVSIINMALMS----------AELSWL----------DLQLLEILEYVCISWFT 220 230 240 250 290 300 310 320 330 340 pF1KE4 FEVSSRLLLAPSTRNFFCHPLNLIDIVSVLPFYLTLLAGVALGDQGGKEFGHLGKVVQVF : :.: . . :. . :.::....::::.:::. :.: .:. ..:..:::. NP_055 GEFVLRFLCVRDRCRFLRKVPNIIDLLAILPFYITLLVESLSGSQTTQELENVGRIVQVL 260 270 280 290 300 310 350 360 370 380 390 400 pF1KE4 RLMRIFRVLKLARHSTGLRSLGATLKHSYREVGILLLYLAVGVSVFSGVAYTAEKE-EDV ::.: .:.:::.:::::::::: :. . :.:::.:::.:.::.:.:: : : ::. :. NP_055 RLLRALRMLKLGRHSTGLRSLGMTITQCYEEVGLLLLFLSVGISIFSTVEYFAEQSIPDT 320 330 340 350 360 370 410 420 430 440 450 460 pF1KE4 GFNTIPACWWWGTVSMTTVGYGDVVPVTVAGKLAASGCILGGILVVALPITIIFNKFSHF :...: :::.:.:::::::::. : :..::..: :::.::::.::::.:: ..:: NP_055 TFTSVPCAWWWATTSMTTVGYGDIRPDTTTGKIVAFMCILSGILVLALPIAIINDRFSAC 380 390 400 410 420 430 470 480 490 500 510 520 pF1KE4 YRRQKALEAAVRNSNHQEFEDLLSSVDGVSEASLETSRETSQEGQSADLESQAPSEPPHP : : ::::: NP_055 YFTLKLKEAAVRQREALKKLTKNIATDSYISVNLRDVYARSIMEMLRLKGRERASTRSSG 440 450 460 470 480 490 >>XP_016869471 (OMIM: 607738) PREDICTED: potassium volta (666 aa) initn: 674 init1: 288 opt: 652 Z-score: 699.9 bits: 139.5 E(85289): 3e-32 Smith-Waterman score: 663; 43.4% identity (77.7% similar) in 242 aa overlap (290-518:6-245) 260 270 280 290 300 310 pF1KE4 GRSPEGVRDDPVLRRLEYFCIAWFSFEVSSRLLLAPSTRNFFCHPLNLIDIVSVLPFYLT :.: .:. .:: :::.::....::.:.: XP_016 MEYLLRFLSSPNKWKFFKGPLNVIDLLAILPYYVT 10 20 30 320 330 340 350 360 370 pF1KE4 LLAGVALGDQGGKEFGHLGKVVQVFRLMRIFRVLKLARHSTGLRSLGATLKHSYREVGIL .. .. .... .: .. .:::.::.:::.:.::::::::::.::: ::..:: :.:.: XP_016 IF--LTESNKSVLQFQNVRRVVQIFRIMRILRILKLARHSTGLQSLGFTLRRSYNELGLL 40 50 60 70 80 90 380 390 400 410 420 430 pF1KE4 LLYLAVGVSVFSGVAYTAEKEEDVG-FNTIPACWWWGTVSMTTVGYGDVVPVTVAGKLAA .:.::.:. .::.... :::.::. :..::: .::.:..::::::::. : :. ::... XP_016 ILFLAMGIMIFSSLVFFAEKDEDATKFTSIPASFWWATITMTTVGYGDIYPKTLLGKIVG 100 110 120 130 140 150 440 450 460 470 480 pF1KE4 SGCILGGILVVALPITIIFNKFSHFYRRQK----------ALEAAVRNSN--HQEFEDLL . : ..:.::.:::: :: :.::.::..:: ::: : ::.. ....: . XP_016 GLCCIAGVLVIALPIPIIVNNFSEFYKEQKRQEKAIKRREALERAKRNGSIVSMNLKDAF 160 170 180 190 200 210 490 500 510 520 pF1KE4 SSVDGVSEASLETSRETSQEGQSADLESQAPSEPPHPQMY . . ....: . :... .::: . .:: XP_016 ARSMELIDVAVEKAGESANTKDSADDNHLSPSRWKWARKALSETSSNKSFENKYQEVSQK 220 230 240 250 260 270 XP_016 DSHEQLNNTSSSSPQHLSAQKLEMLYNEITKTQPHSHPNPDCQEKPERPSAYEEEIEMEE 280 290 300 310 320 330 >>XP_016869470 (OMIM: 607738) PREDICTED: potassium volta (666 aa) initn: 674 init1: 288 opt: 652 Z-score: 699.9 bits: 139.5 E(85289): 3e-32 Smith-Waterman score: 663; 43.4% identity (77.7% similar) in 242 aa overlap (290-518:6-245) 260 270 280 290 300 310 pF1KE4 GRSPEGVRDDPVLRRLEYFCIAWFSFEVSSRLLLAPSTRNFFCHPLNLIDIVSVLPFYLT :.: .:. .:: :::.::....::.:.: XP_016 MEYLLRFLSSPNKWKFFKGPLNVIDLLAILPYYVT 10 20 30 320 330 340 350 360 370 pF1KE4 LLAGVALGDQGGKEFGHLGKVVQVFRLMRIFRVLKLARHSTGLRSLGATLKHSYREVGIL .. .. .... .: .. .:::.::.:::.:.::::::::::.::: ::..:: :.:.: XP_016 IF--LTESNKSVLQFQNVRRVVQIFRIMRILRILKLARHSTGLQSLGFTLRRSYNELGLL 40 50 60 70 80 90 380 390 400 410 420 430 pF1KE4 LLYLAVGVSVFSGVAYTAEKEEDVG-FNTIPACWWWGTVSMTTVGYGDVVPVTVAGKLAA .:.::.:. .::.... :::.::. :..::: .::.:..::::::::. : :. ::... XP_016 ILFLAMGIMIFSSLVFFAEKDEDATKFTSIPASFWWATITMTTVGYGDIYPKTLLGKIVG 100 110 120 130 140 150 440 450 460 470 480 pF1KE4 SGCILGGILVVALPITIIFNKFSHFYRRQK----------ALEAAVRNSN--HQEFEDLL . : ..:.::.:::: :: :.::.::..:: ::: : ::.. ....: . XP_016 GLCCIAGVLVIALPIPIIVNNFSEFYKEQKRQEKAIKRREALERAKRNGSIVSMNLKDAF 160 170 180 190 200 210 490 500 510 520 pF1KE4 SSVDGVSEASLETSRETSQEGQSADLESQAPSEPPHPQMY . . ....: . :... .::: . .:: XP_016 ARSMELIDVAVEKAGESANTKDSADDNHLSPSRWKWARKALSETSSNKSFENKYQEVSQK 220 230 240 250 260 270 XP_016 DSHEQLNNTSSSSPQHLSAQKLEMLYNEITKTQPHSHPNPDCQEKPERPSAYEEEIEMEE 280 290 300 310 320 330 526 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 01:52:17 2016 done: Sun Nov 6 01:52:18 2016 Total Scan time: 10.630 Total Display time: 0.070 Function used was FASTA [36.3.4 Apr, 2011]