Result of FASTA (omim) for
pFN21AE1651
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE1651, 145 aa
1>>>pF1KE1651 145 - 145 aa - 145 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.7943+/-0.000295; mu= 14.3122+/- 0.018
mean_var=57.1438+/-11.380, 0's: 0 Z-trim(117.3): 29 B-trim: 0 in 0/55
Lambda= 0.169664
statistics sampled from 29158 (29187) to 29158 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.736), E-opt: 0.2 (0.342), width: 16
Scan time: 5.100
The best scores are: opt bits E(85289)
NP_003641 (OMIM: 603253) cystatin-F precursor [Hom ( 145) 1002 252.7 1.6e-67
NP_001275543 (OMIM: 105150,604312,611953) cystatin ( 146) 254 69.6 2.1e-12
NP_000090 (OMIM: 105150,604312,611953) cystatin-C ( 146) 254 69.6 2.1e-12
NP_001890 (OMIM: 123857) cystatin-S precursor [Hom ( 141) 235 64.9 5e-11
NP_001889 (OMIM: 123855) cystatin-SN precursor [Ho ( 141) 233 64.4 7.1e-11
NP_001314 (OMIM: 601891) cystatin-M precursor [Hom ( 149) 228 63.2 1.7e-10
NP_001313 (OMIM: 123856) cystatin-SA precursor [Ho ( 141) 226 62.7 2.3e-10
NP_001159923 (OMIM: 228960,612358) kininogen-1 iso ( 391) 228 63.5 3.8e-10
NP_000884 (OMIM: 228960,612358) kininogen-1 isofor ( 427) 228 63.5 4.1e-10
NP_001095886 (OMIM: 228960,612358) kininogen-1 iso ( 644) 228 63.6 5.7e-10
NP_001891 (OMIM: 123858) cystatin-D precursor [Hom ( 142) 201 56.6 1.6e-08
NP_001268659 (OMIM: 608683) cystatin-8 precursor [ ( 142) 192 54.4 7.5e-08
NP_005483 (OMIM: 608683) cystatin-8 precursor [Hom ( 142) 192 54.4 7.5e-08
NP_570612 (OMIM: 609731) cystatin-11 isoform 1 pre ( 138) 157 45.8 2.8e-05
NP_542177 (OMIM: 616536) cystatin-9-like precursor ( 147) 153 44.9 5.7e-05
XP_005247408 (OMIM: 605954) PREDICTED: fetuin-B is ( 234) 131 39.6 0.0035
XP_011510985 (OMIM: 605954) PREDICTED: fetuin-B is ( 234) 131 39.6 0.0035
XP_011510984 (OMIM: 605954) PREDICTED: fetuin-B is ( 277) 131 39.6 0.004
NP_001295008 (OMIM: 605954) fetuin-B isoform 3 pre ( 317) 131 39.7 0.0045
NP_001295006 (OMIM: 605954) fetuin-B isoform 2 pre ( 345) 131 39.7 0.0048
>>NP_003641 (OMIM: 603253) cystatin-F precursor [Homo sa (145 aa)
initn: 1002 init1: 1002 opt: 1002 Z-score: 1333.4 bits: 252.7 E(85289): 1.6e-67
Smith-Waterman score: 1002; 100.0% identity (100.0% similar) in 145 aa overlap (1-145:1-145)
10 20 30 40 50 60
pF1KE1 MRAAGTLLAFCCLVLSTTGGPSPDTCSQDLNSRVKPGFPKTIKTNDPGVLQAARYSVEKF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 MRAAGTLLAFCCLVLSTTGGPSPDTCSQDLNSRVKPGFPKTIKTNDPGVLQAARYSVEKF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 NNCTNDMFLFKESRITRALVQIVKGLKYMLEVEIGRTTCKKNQHLRLDDCDFQTNHTLKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 NNCTNDMFLFKESRITRALVQIVKGLKYMLEVEIGRTTCKKNQHLRLDDCDFQTNHTLKQ
70 80 90 100 110 120
130 140
pF1KE1 TLSCYSEVWVVPWLQHFEVPVLRCH
:::::::::::::::::::::::::
NP_003 TLSCYSEVWVVPWLQHFEVPVLRCH
130 140
>>NP_001275543 (OMIM: 105150,604312,611953) cystatin-C p (146 aa)
initn: 270 init1: 176 opt: 254 Z-score: 343.8 bits: 69.6 E(85289): 2.1e-12
Smith-Waterman score: 254; 35.6% identity (63.0% similar) in 135 aa overlap (1-133:5-132)
10 20 30 40 50
pF1KE1 MRAAGTLLAF--CCLVLSTTGGPSPDTCSQDLNSRVKPGFPKTIKTNDPGVLQAAR
.:: :::. :..: ..: :: :. : : .... :: .:
NP_001 MAGPLRAPLLLLAILAVALAVSPAAGSSPGK-----PPRLVGG-PMDASVEEEGVRRALD
10 20 30 40 50
60 70 80 90 100 110
pF1KE1 YSVEKFNNCTNDMFLFKESRITRALVQIVKGLKYMLEVEIGRTTCKKNQHLRLDDCDFQT
..: ..:. .:::. . ...:: ::: :..:.:.::.::::: :.: ::.: :.
NP_001 FAVGEYNKASNDMYHSRALQVVRARKQIVAGVNYFLDVELGRTTCTKTQP-NLDNCPFHD
60 70 80 90 100 110
120 130 140
pF1KE1 NHTLKQTLSCYSEVWVVPWLQHFEVPVLRCH
. ::. : ....:::
NP_001 QPHLKRKAFCSFQIYAVPWQGTMTLSKSTCQDA
120 130 140
>>NP_000090 (OMIM: 105150,604312,611953) cystatin-C prec (146 aa)
initn: 270 init1: 176 opt: 254 Z-score: 343.8 bits: 69.6 E(85289): 2.1e-12
Smith-Waterman score: 254; 35.6% identity (63.0% similar) in 135 aa overlap (1-133:5-132)
10 20 30 40 50
pF1KE1 MRAAGTLLAF--CCLVLSTTGGPSPDTCSQDLNSRVKPGFPKTIKTNDPGVLQAAR
.:: :::. :..: ..: :: :. : : .... :: .:
NP_000 MAGPLRAPLLLLAILAVALAVSPAAGSSPGK-----PPRLVGG-PMDASVEEEGVRRALD
10 20 30 40 50
60 70 80 90 100 110
pF1KE1 YSVEKFNNCTNDMFLFKESRITRALVQIVKGLKYMLEVEIGRTTCKKNQHLRLDDCDFQT
..: ..:. .:::. . ...:: ::: :..:.:.::.::::: :.: ::.: :.
NP_000 FAVGEYNKASNDMYHSRALQVVRARKQIVAGVNYFLDVELGRTTCTKTQP-NLDNCPFHD
60 70 80 90 100 110
120 130 140
pF1KE1 NHTLKQTLSCYSEVWVVPWLQHFEVPVLRCH
. ::. : ....:::
NP_000 QPHLKRKAFCSFQIYAVPWQGTMTLSKSTCQDA
120 130 140
>>NP_001890 (OMIM: 123857) cystatin-S precursor [Homo sa (141 aa)
initn: 218 init1: 145 opt: 235 Z-score: 318.9 bits: 64.9 E(85289): 5e-11
Smith-Waterman score: 235; 29.0% identity (59.4% similar) in 138 aa overlap (10-145:5-139)
10 20 30 40 50
pF1KE1 MRAAGTLLAFCCLVL--STTGGPSPDTCSQDLNSRVKPGFPKTIKTNDPGVLQAARYSVE
.: :.: .: .: .. ... .:. :: :: : .: ....
NP_001 MARPLCTLLLLMATLAGALASSSKEE--NRIIPGGIYDADLNDEWVQRALHFAIS
10 20 30 40 50
60 70 80 90 100 110
pF1KE1 KFNNCTNDMFLFKESRITRALVQIVKGLKYMLEVEIGRTTCKKNQHLRLDDCDFQTNHTL
..:. :.: . . .. :: : :..:...::.::: : :.: :: : :. . :
NP_001 EYNKATEDEYYRRPLQVLRAREQTFGGVNYFFDVEVGRTICTKSQP-NLDTCAFHEQPEL
60 70 80 90 100 110
120 130 140
pF1KE1 KQTLSCYSEVWVVPWLQHFEVPVLRCH
.. : :.. ::: ... . ::.
NP_001 QKKQLCSFEIYEVPWEDRMSLVNSRCQEA
120 130 140
>>NP_001889 (OMIM: 123855) cystatin-SN precursor [Homo s (141 aa)
initn: 226 init1: 156 opt: 233 Z-score: 316.3 bits: 64.4 E(85289): 7.1e-11
Smith-Waterman score: 233; 32.7% identity (60.2% similar) in 113 aa overlap (33-145:28-139)
10 20 30 40 50 60
pF1KE1 AAGTLLAFCCLVLSTTGGPSPDTCSQDLNSRVKPGFPKTIKTNDPGVLQAARYSVEKFNN
:. :: . :: : .: .... ..:.
NP_001 MAQYLSTLLLLLATLAVALAWSPKEEDRIIPGGIYNADLNDEWVQRALHFAISEYNK
10 20 30 40 50
70 80 90 100 110 120
pF1KE1 CTNDMFLFKESRITRALVQIVKGLKYMLEVEIGRTTCKKNQHLRLDDCDFQTNHTLKQTL
:.: . . :. :: : : :..:...::.::: : :.: :: : :. . :..
NP_001 ATKDDYYRRPLRVLRARQQTVGGVNYFFDVEVGRTICTKSQP-NLDTCAFHEQPELQKKQ
60 70 80 90 100 110
130 140
pF1KE1 SCYSEVWVVPWLQHFEVPVLRCH
: :.. ::: .. . ::.
NP_001 LCSFEIYEVPWENRRSLVKSRCQES
120 130 140
>>NP_001314 (OMIM: 601891) cystatin-M precursor [Homo sa (149 aa)
initn: 212 init1: 162 opt: 228 Z-score: 309.3 bits: 63.2 E(85289): 1.7e-10
Smith-Waterman score: 228; 32.8% identity (61.8% similar) in 131 aa overlap (7-133:14-135)
10 20 30 40 50
pF1KE1 MRAAGTLLAFCCLVLSTTGGPSPDTCSQDLNSRVKPGFPKTIKTNDPGVLQAA
:.::: :.: . : :. :. : . .. .:: : .::
NP_001 MARSNLPLALGLALVAFCLLALPRDARARP----QE---RMV-GELRDLSPDDPQVQKAA
10 20 30 40 50
60 70 80 90 100
pF1KE1 RYSVEKFNNCTNDMFLFKESRITRALVQIVKGLKYMLEVEIGRTTCKKNQ----HLRLDD
. .: ..: .:... :....: .: :.: :.::.: .:.: : :.:.. :. :
NP_001 QAAVASYNMGSNSIYYFRDTHIIKAQSQLVAGIKYFLTMEMGSTDCRKTRVTGDHVDLTT
60 70 80 90 100 110
110 120 130 140
pF1KE1 CDFQTNHTLKQTLSCYSEVWVVPWLQHFEVPVLRCH
: . .. . .. : : :: ::::
NP_001 CPLAAG-AQQEKLRCDFEVLVVPWQNSSQLLKHNCVQM
120 130 140
>>NP_001313 (OMIM: 123856) cystatin-SA precursor [Homo s (141 aa)
initn: 236 init1: 152 opt: 226 Z-score: 307.0 bits: 62.7 E(85289): 2.3e-10
Smith-Waterman score: 226; 28.7% identity (57.4% similar) in 136 aa overlap (10-145:5-139)
10 20 30 40 50 60
pF1KE1 MRAAGTLLAFCCLVLSTTGGPSPDTCSQDLNSRVKPGFPKTIKTNDPGVLQAARYSVEKF
.: :.: . . : . ..:. : :: : .: .. . ..
NP_001 MAWPLCTLLLLLATQAVALAWSPQEEDRIIEGGIYDADLNDERVQRALHFVISEY
10 20 30 40 50
70 80 90 100 110 120
pF1KE1 NNCTNDMFLFKESRITRALVQIVKGLKYMLEVEIGRTTCKKNQHLRLDDCDFQTNHTLKQ
:. :.: . . :. :: ::: :..:....:.::: : :.: :: : :. . :..
NP_001 NKATEDEYYRRLLRVLRAREQIVGGVNYFFDIEVGRTICTKSQP-NLDTCAFHEQPELQK
60 70 80 90 100 110
130 140
pF1KE1 TLSCYSEVWVVPWLQHFEVPVLRCH
: ... ::: ... . ::.
NP_001 KQLCSFQIYEVPWEDRMSLVNSRCQEA
120 130 140
>>NP_001159923 (OMIM: 228960,612358) kininogen-1 isoform (391 aa)
initn: 234 init1: 129 opt: 228 Z-score: 303.2 bits: 63.5 E(85289): 3.8e-10
Smith-Waterman score: 228; 32.2% identity (67.0% similar) in 115 aa overlap (32-145:225-335)
10 20 30 40 50 60
pF1KE1 RAAGTLLAFCCLVLSTTGGPSPDTCSQDLNSRVKPGFPKTIKTNDPGVLQAARYSVEKFN
... : :. : ::.: . .. ... :.:
NP_001 DNAYIDIQLRIASFSQNCDIYPGKDFVQPPTKICVGCPRDIPTNSPELEETLTHTITKLN
200 210 220 230 240 250
70 80 90 100 110 120
pF1KE1 NCTNDMFLFKESRITRALVQIVKGLKYMLEVEIGRTTCKKNQHLRL-DDCDFQTNHTLKQ
.: : :: . . .: ::.: : ::... .:::.:... .: ..:. . : :
NP_001 AENNATFYFKIDNVKKARVQVVAGKKYFIDFVARETTCSKESNEELTESCETK---KLGQ
260 270 280 290 300 310
130 140
pF1KE1 TLSCYSEVWVVPWLQHFEVPVLRCH
.:.: .::.:::: ... :.. :.
NP_001 SLDCNAEVYVVPWEKKI-YPTVNCQPLGMISLMKRPPGFSPFRSSRIGEIKEETTSHLRS
320 330 340 350 360 370
>>NP_000884 (OMIM: 228960,612358) kininogen-1 isoform 2 (427 aa)
initn: 192 init1: 129 opt: 228 Z-score: 302.6 bits: 63.5 E(85289): 4.1e-10
Smith-Waterman score: 228; 32.2% identity (67.0% similar) in 115 aa overlap (32-145:261-371)
10 20 30 40 50 60
pF1KE1 RAAGTLLAFCCLVLSTTGGPSPDTCSQDLNSRVKPGFPKTIKTNDPGVLQAARYSVEKFN
... : :. : ::.: . .. ... :.:
NP_000 DNAYIDIQLRIASFSQNCDIYPGKDFVQPPTKICVGCPRDIPTNSPELEETLTHTITKLN
240 250 260 270 280 290
70 80 90 100 110 120
pF1KE1 NCTNDMFLFKESRITRALVQIVKGLKYMLEVEIGRTTCKKNQHLRL-DDCDFQTNHTLKQ
.: : :: . . .: ::.: : ::... .:::.:... .: ..:. . : :
NP_000 AENNATFYFKIDNVKKARVQVVAGKKYFIDFVARETTCSKESNEELTESCETK---KLGQ
300 310 320 330 340
130 140
pF1KE1 TLSCYSEVWVVPWLQHFEVPVLRCH
.:.: .::.:::: ... :.. :.
NP_000 SLDCNAEVYVVPWEKKI-YPTVNCQPLGMISLMKRPPGFSPFRSSRIGEIKEETTSHLRS
350 360 370 380 390 400
>>NP_001095886 (OMIM: 228960,612358) kininogen-1 isoform (644 aa)
initn: 192 init1: 129 opt: 228 Z-score: 300.0 bits: 63.6 E(85289): 5.7e-10
Smith-Waterman score: 228; 32.2% identity (67.0% similar) in 115 aa overlap (32-145:261-371)
10 20 30 40 50 60
pF1KE1 RAAGTLLAFCCLVLSTTGGPSPDTCSQDLNSRVKPGFPKTIKTNDPGVLQAARYSVEKFN
... : :. : ::.: . .. ... :.:
NP_001 DNAYIDIQLRIASFSQNCDIYPGKDFVQPPTKICVGCPRDIPTNSPELEETLTHTITKLN
240 250 260 270 280 290
70 80 90 100 110 120
pF1KE1 NCTNDMFLFKESRITRALVQIVKGLKYMLEVEIGRTTCKKNQHLRL-DDCDFQTNHTLKQ
.: : :: . . .: ::.: : ::... .:::.:... .: ..:. . : :
NP_001 AENNATFYFKIDNVKKARVQVVAGKKYFIDFVARETTCSKESNEELTESCETK---KLGQ
300 310 320 330 340
130 140
pF1KE1 TLSCYSEVWVVPWLQHFEVPVLRCH
.:.: .::.:::: ... :.. :.
NP_001 SLDCNAEVYVVPWEKKI-YPTVNCQPLGMISLMKRPPGFSPFRSSRIGEIKEETTVSPPH
350 360 370 380 390 400
145 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 13:06:21 2016 done: Sun Nov 6 13:06:21 2016
Total Scan time: 5.100 Total Display time: -0.010
Function used was FASTA [36.3.4 Apr, 2011]