FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB7802, 590 aa 1>>>pF1KB7802 590 - 590 aa - 590 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 8.9670+/-0.000326; mu= 4.0505+/- 0.020 mean_var=240.0974+/-48.844, 0's: 0 Z-trim(123.7): 161 B-trim: 835 in 1/61 Lambda= 0.082771 statistics sampled from 43900 (44096) to 43900 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.797), E-opt: 0.2 (0.517), width: 16 Scan time: 12.220 The best scores are: opt bits E(85289) NP_002508 (OMIM: 603346) neuronal PAS domain-conta ( 590) 4026 493.6 7.5e-139 XP_011525299 (OMIM: 603346) PREDICTED: neuronal PA ( 591) 4014 492.2 2e-138 XP_011525301 (OMIM: 603346) PREDICTED: neuronal PA ( 580) 2399 299.3 2.3e-80 XP_006723294 (OMIM: 603346) PREDICTED: neuronal PA ( 410) 2361 294.7 4e-79 XP_016882331 (OMIM: 603346) PREDICTED: neuronal PA ( 650) 2361 294.9 5.7e-79 XP_011525304 (OMIM: 603346) PREDICTED: neuronal PA ( 454) 2353 293.8 8.5e-79 XP_011525309 (OMIM: 603346) PREDICTED: neuronal PA ( 411) 2349 293.2 1.1e-78 XP_011525308 (OMIM: 603346) PREDICTED: neuronal PA ( 411) 2349 293.2 1.1e-78 XP_016882332 (OMIM: 603346) PREDICTED: neuronal PA ( 582) 2349 293.4 1.4e-78 XP_016882330 (OMIM: 603346) PREDICTED: neuronal PA ( 651) 2349 293.4 1.5e-78 XP_016882333 (OMIM: 603346) PREDICTED: neuronal PA ( 519) 1673 212.6 2.6e-54 XP_011525303 (OMIM: 603346) PREDICTED: neuronal PA ( 483) 1553 198.3 5.1e-50 NP_001308015 (OMIM: 603346) neuronal PAS domain-co ( 234) 1186 154.2 4.6e-37 XP_016877075 (OMIM: 609430) PREDICTED: neuronal PA ( 831) 579 82.1 7.8e-15 XP_016877076 (OMIM: 609430) PREDICTED: neuronal PA ( 831) 579 82.1 7.8e-15 XP_016877077 (OMIM: 609430) PREDICTED: neuronal PA ( 831) 579 82.1 7.8e-15 NP_071406 (OMIM: 609430) neuronal PAS domain-conta ( 901) 579 82.2 8.3e-15 NP_001159365 (OMIM: 609430) neuronal PAS domain-co ( 903) 579 82.2 8.3e-15 XP_011535372 (OMIM: 609430) PREDICTED: neuronal PA ( 918) 579 82.2 8.4e-15 NP_775182 (OMIM: 609430) neuronal PAS domain-conta ( 920) 579 82.2 8.4e-15 NP_001158221 (OMIM: 609430) neuronal PAS domain-co ( 933) 579 82.2 8.5e-15 XP_016877074 (OMIM: 609430) PREDICTED: neuronal PA ( 939) 579 82.2 8.6e-15 XP_011535369 (OMIM: 609430) PREDICTED: neuronal PA ( 950) 579 82.2 8.6e-15 XP_016877073 (OMIM: 609430) PREDICTED: neuronal PA ( 956) 579 82.2 8.7e-15 XP_005268049 (OMIM: 609430) PREDICTED: neuronal PA ( 967) 579 82.2 8.7e-15 XP_005268048 (OMIM: 609430) PREDICTED: neuronal PA ( 969) 579 82.2 8.8e-15 XP_016877071 (OMIM: 609430) PREDICTED: neuronal PA ( 986) 579 82.2 8.9e-15 XP_011535374 (OMIM: 609430) PREDICTED: neuronal PA ( 900) 573 81.5 1.4e-14 XP_011535373 (OMIM: 609430) PREDICTED: neuronal PA ( 936) 573 81.5 1.4e-14 XP_011535371 (OMIM: 609430) PREDICTED: neuronal PA ( 966) 573 81.5 1.4e-14 XP_016877072 (OMIM: 609430) PREDICTED: neuronal PA ( 983) 573 81.5 1.5e-14 NP_001612 (OMIM: 600253) aryl hydrocarbon receptor ( 848) 406 61.5 1.3e-08 XP_011534374 (OMIM: 601665,603128) PREDICTED: sing ( 481) 392 59.6 2.7e-08 XP_005267157 (OMIM: 601665,603128) PREDICTED: sing ( 766) 392 59.8 3.9e-08 XP_016866686 (OMIM: 601665,603128) PREDICTED: sing ( 766) 392 59.8 3.9e-08 NP_005059 (OMIM: 601665,603128) single-minded homo ( 766) 392 59.8 3.9e-08 NP_001229341 (OMIM: 606517) aryl hydrocarbon recep ( 701) 370 57.1 2.2e-07 XP_011527996 (OMIM: 600892) PREDICTED: single-mind ( 566) 361 56.0 4e-07 NP_033664 (OMIM: 600892) single-minded homolog 2 s ( 570) 361 56.0 4.1e-07 NP_005060 (OMIM: 600892) single-minded homolog 2 l ( 667) 361 56.0 4.6e-07 XP_016883931 (OMIM: 600892) PREDICTED: single-mind ( 327) 328 51.8 4.1e-06 NP_065782 (OMIM: 606517) aryl hydrocarbon receptor ( 719) 325 51.8 9.5e-06 NP_851397 (OMIM: 603348) hypoxia-inducible factor ( 735) 292 47.8 0.00015 NP_001521 (OMIM: 603348) hypoxia-inducible factor ( 826) 292 47.9 0.00016 NP_001230013 (OMIM: 603348) hypoxia-inducible fact ( 850) 292 47.9 0.00016 NP_690009 (OMIM: 609976) hypoxia-inducible factor ( 450) 281 46.3 0.00026 XP_016882631 (OMIM: 609976) PREDICTED: hypoxia-ind ( 474) 281 46.4 0.00027 XP_005259212 (OMIM: 609976) PREDICTED: hypoxia-ind ( 587) 281 46.4 0.00031 XP_005259213 (OMIM: 609976) PREDICTED: hypoxia-ind ( 587) 281 46.4 0.00031 XP_005259210 (OMIM: 609976) PREDICTED: hypoxia-ind ( 594) 281 46.4 0.00031 >>NP_002508 (OMIM: 603346) neuronal PAS domain-containin (590 aa) initn: 4026 init1: 4026 opt: 4026 Z-score: 2613.9 bits: 493.6 E(85289): 7.5e-139 Smith-Waterman score: 4026; 100.0% identity (100.0% similar) in 590 aa overlap (1-590:1-590) 10 20 30 40 50 60 pF1KB7 MAAPYPGSGGGSEVKCVGGRGASVPWDFLPGLMVKAPSGPCLQAQRKEKSRNAARSRRGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 MAAPYPGSGGGSEVKCVGGRGASVPWDFLPGLMVKAPSGPCLQAQRKEKSRNAARSRRGK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 ENLEFFELAKLLPLPGAISSQLDKASIVRLSVTYLRLRRFAALGAPPWGLRAAGPPAGLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 ENLEFFELAKLLPLPGAISSQLDKASIVRLSVTYLRLRRFAALGAPPWGLRAAGPPAGLA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 PGRRGPAALVSEVFEQHLGGHILQSLDGFVFALNQEGKFLYISETVSIYLGLSQVEMTGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 PGRRGPAALVSEVFEQHLGGHILQSLDGFVFALNQEGKFLYISETVSIYLGLSQVEMTGS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 SVFDYIHPGDHSEVLEQLGLRTPTPGPPTPPSVSSSSSSSSSLADTPEIEASLTKVPPSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 SVFDYIHPGDHSEVLEQLGLRTPTPGPPTPPSVSSSSSSSSSLADTPEIEASLTKVPPSS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB7 LVQERSFFVRMKSTLTKRGLHVKASGYKVIHVTGRLRAHALGLVALGHTLPPAPLAELPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 LVQERSFFVRMKSTLTKRGLHVKASGYKVIHVTGRLRAHALGLVALGHTLPPAPLAELPL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB7 HGHMIVFRLSLGLTILACESRVSDHMDLGPSELVGRSCYQFVHGQDATRIRQSHVDLLDK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 HGHMIVFRLSLGLTILACESRVSDHMDLGPSELVGRSCYQFVHGQDATRIRQSHVDLLDK 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB7 GQVMTGYYRWLQRAGGFVWLQSVATVAGSGKSPGEHHVLWVSHVLSQAEGGQTPLDAFQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 GQVMTGYYRWLQRAGGFVWLQSVATVAGSGKSPGEHHVLWVSHVLSQAEGGQTPLDAFQL 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB7 PASVACEEASSPGPEPTEPEPPTEGKQAAPAENEAPQTQGKRIKVEPGPRETKGSEDSGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 PASVACEEASSPGPEPTEPEPPTEGKQAAPAENEAPQTQGKRIKVEPGPRETKGSEDSGD 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB7 EDPSSHPATPRPEFTSVIRAGVLKQDPVRPWGLAPPGDPPPTLLHAGFLPPVVRGLCTPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 EDPSSHPATPRPEFTSVIRAGVLKQDPVRPWGLAPPGDPPPTLLHAGFLPPVVRGLCTPG 490 500 510 520 530 540 550 560 570 580 590 pF1KB7 TIRYGPAELGLVYPHLQRLGPGPALPEAFYPPLGLPYPGPAGTRLPRKGD :::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 TIRYGPAELGLVYPHLQRLGPGPALPEAFYPPLGLPYPGPAGTRLPRKGD 550 560 570 580 590 >>XP_011525299 (OMIM: 603346) PREDICTED: neuronal PAS do (591 aa) initn: 2260 init1: 2260 opt: 4014 Z-score: 2606.1 bits: 492.2 E(85289): 2e-138 Smith-Waterman score: 4014; 99.8% identity (99.8% similar) in 591 aa overlap (1-590:1-591) 10 20 30 40 50 60 pF1KB7 MAAPYPGSGGGSEVKCVGGRGASVPWDFLPGLMVKAPSGPCLQAQRKEKSRNAARSRRGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MAAPYPGSGGGSEVKCVGGRGASVPWDFLPGLMVKAPSGPCLQAQRKEKSRNAARSRRGK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 ENLEFFELAKLLPLPGAISSQLDKASIVRLSVTYLRLRRFAALGAPPWGLRAAGPPAGLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ENLEFFELAKLLPLPGAISSQLDKASIVRLSVTYLRLRRFAALGAPPWGLRAAGPPAGLA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 PGRRGPAALVSEVFEQHLGGHILQSLDGFVFALNQEGKFLYISETVSIYLGLSQVEMTGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PGRRGPAALVSEVFEQHLGGHILQSLDGFVFALNQEGKFLYISETVSIYLGLSQVEMTGS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 SVFDYIHPGDHSEVLEQLGLRTPTPGPPTPPSVSSSSSSSSSLADTPEIEASLTKVPPSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SVFDYIHPGDHSEVLEQLGLRTPTPGPPTPPSVSSSSSSSSSLADTPEIEASLTKVPPSS 190 200 210 220 230 240 250 260 270 280 290 pF1KB7 LVQERSFFVRMKSTLTKRGLHVKASGYK-VIHVTGRLRAHALGLVALGHTLPPAPLAELP :::::::::::::::::::::::::::: ::::::::::::::::::::::::::::::: XP_011 LVQERSFFVRMKSTLTKRGLHVKASGYKQVIHVTGRLRAHALGLVALGHTLPPAPLAELP 250 260 270 280 290 300 300 310 320 330 340 350 pF1KB7 LHGHMIVFRLSLGLTILACESRVSDHMDLGPSELVGRSCYQFVHGQDATRIRQSHVDLLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LHGHMIVFRLSLGLTILACESRVSDHMDLGPSELVGRSCYQFVHGQDATRIRQSHVDLLD 310 320 330 340 350 360 360 370 380 390 400 410 pF1KB7 KGQVMTGYYRWLQRAGGFVWLQSVATVAGSGKSPGEHHVLWVSHVLSQAEGGQTPLDAFQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KGQVMTGYYRWLQRAGGFVWLQSVATVAGSGKSPGEHHVLWVSHVLSQAEGGQTPLDAFQ 370 380 390 400 410 420 420 430 440 450 460 470 pF1KB7 LPASVACEEASSPGPEPTEPEPPTEGKQAAPAENEAPQTQGKRIKVEPGPRETKGSEDSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LPASVACEEASSPGPEPTEPEPPTEGKQAAPAENEAPQTQGKRIKVEPGPRETKGSEDSG 430 440 450 460 470 480 480 490 500 510 520 530 pF1KB7 DEDPSSHPATPRPEFTSVIRAGVLKQDPVRPWGLAPPGDPPPTLLHAGFLPPVVRGLCTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DEDPSSHPATPRPEFTSVIRAGVLKQDPVRPWGLAPPGDPPPTLLHAGFLPPVVRGLCTP 490 500 510 520 530 540 540 550 560 570 580 590 pF1KB7 GTIRYGPAELGLVYPHLQRLGPGPALPEAFYPPLGLPYPGPAGTRLPRKGD ::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GTIRYGPAELGLVYPHLQRLGPGPALPEAFYPPLGLPYPGPAGTRLPRKGD 550 560 570 580 590 >>XP_011525301 (OMIM: 603346) PREDICTED: neuronal PAS do (580 aa) initn: 1807 init1: 1769 opt: 2399 Z-score: 1563.9 bits: 299.3 E(85289): 2.3e-80 Smith-Waterman score: 2423; 71.0% identity (79.2% similar) in 576 aa overlap (1-568:1-550) 10 20 30 40 50 60 pF1KB7 MAAPYPGSGGGSEVKCVGGRGASVPWDFLPGLMVKAPSGPCLQAQRKEKSRNAARSRRGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MAAPYPGSGGGSEVKCVGGRGASVPWDFLPGLMVKAPSGPCLQAQRKEKSRNAARSRRGK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 ENLEFFELAKLLPLPGAISSQLDKASIVRLSVTYLRLRRFAALGAPPWGLRAAGPPAGLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ENLEFFELAKLLPLPGAISSQLDKASIVRLSVTYLRLRRFAALGAPPWGLRAAGPPAGLA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 PGRRGPAALVSEVFEQHLGGHILQSLDGFVFALNQEGKFLYISETVSIYLGLSQVEMTGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PGRRGPAALVSEVFEQHLGGHILQSLDGFVFALNQEGKFLYISETVSIYLGLSQVEMTGS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 SVFDYIHPGDHSEVLEQLGLRTPTPGPPTPPSVSSSSSSSSSLADTPEIEASLTKVPPSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SVFDYIHPGDHSEVLEQLGLRTPTPGPPTPPSVSSSSSSSSSLADTPEIEASLTKVPPSS 190 200 210 220 230 240 250 260 270 280 290 pF1KB7 LVQERSFFVRMKSTLTKRGLHVKASGYK-VIHVTGRLRAHALGLVALGHTLPPAPLAELP :::::::::::::::::::::::::::: ::::::::::::::::::::::::::::::: XP_011 LVQERSFFVRMKSTLTKRGLHVKASGYKQVIHVTGRLRAHALGLVALGHTLPPAPLAELP 250 260 270 280 290 300 300 310 320 330 340 350 pF1KB7 LHGHMIVFRLSLGLTILACESRVSDHMDLGPSELVGRSCYQFVHGQDATRIRQSHVDLLD ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: . XP_011 LHGHMIVFRLSLGLTILACESRVSDHMDLGPSELVGRSCYQFVHGQDATRIRQSHVD--S 310 320 330 340 350 360 370 380 390 400 410 pF1KB7 KGQVMTGYYRWLQRAGGFVWLQSVATVAGSGKSPGEHHVLWVSHVLSQAEGGQT--PLDA : .: :. . .: : . :.:: ... ..:.: : . XP_011 KPRVAK--LLWMPSSFQPAW--PVRRHPARGQSPQ----------MGRLRAGDTHRPSAS 360 370 380 390 400 420 430 440 450 460 470 pF1KB7 FQLPASVA-CEEASSPGPEPTEPEP-PTEGKQAAPAENEAPQTQGKRIKVEPGPRETKGS . :... .::. :. : :.: :. . : : :. . : .: ...: : .:.. XP_011 SSSRAGASDGREAGCPSGERGPPDPGQTHQSGARPEGNQRLRGQWRRGSLQP-PGHTEAR 410 420 430 440 450 460 480 490 500 510 520 530 pF1KB7 EDSGDEDPSSHPAT-PRPEFTSVIRAGVLKQDPVRP--WGLAPPGDPPPTLLHAGFLPPV ::. :. ... :. . :..: :: : : .:. : XP_011 VHL------CHPGRGPEAGSGAAMGPGASRGPPAHPPARGLPAAGGAGP--VHTRHHPLR 470 480 490 500 510 540 550 560 570 580 590 pF1KB7 VRGLCTPGTIRYGPAELGLVYPHLQRLGPGPALPEAFYPPLGLPYPGPAGTRLPRKGD :: ::. . : : : .:::::: : XP_011 PRG-AGPGVPAPAEAGSGPRAPGGLLPAPGPALPGARGHQAAAEGGLRTGRAAGAGPCDN 520 530 540 550 560 570 XP_011 RGPPGQ 580 >>XP_006723294 (OMIM: 603346) PREDICTED: neuronal PAS do (410 aa) initn: 2361 init1: 2361 opt: 2361 Z-score: 1541.4 bits: 294.7 E(85289): 4e-79 Smith-Waterman score: 2361; 100.0% identity (100.0% similar) in 356 aa overlap (1-356:1-356) 10 20 30 40 50 60 pF1KB7 MAAPYPGSGGGSEVKCVGGRGASVPWDFLPGLMVKAPSGPCLQAQRKEKSRNAARSRRGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MAAPYPGSGGGSEVKCVGGRGASVPWDFLPGLMVKAPSGPCLQAQRKEKSRNAARSRRGK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 ENLEFFELAKLLPLPGAISSQLDKASIVRLSVTYLRLRRFAALGAPPWGLRAAGPPAGLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ENLEFFELAKLLPLPGAISSQLDKASIVRLSVTYLRLRRFAALGAPPWGLRAAGPPAGLA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 PGRRGPAALVSEVFEQHLGGHILQSLDGFVFALNQEGKFLYISETVSIYLGLSQVEMTGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 PGRRGPAALVSEVFEQHLGGHILQSLDGFVFALNQEGKFLYISETVSIYLGLSQVEMTGS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 SVFDYIHPGDHSEVLEQLGLRTPTPGPPTPPSVSSSSSSSSSLADTPEIEASLTKVPPSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SVFDYIHPGDHSEVLEQLGLRTPTPGPPTPPSVSSSSSSSSSLADTPEIEASLTKVPPSS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB7 LVQERSFFVRMKSTLTKRGLHVKASGYKVIHVTGRLRAHALGLVALGHTLPPAPLAELPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LVQERSFFVRMKSTLTKRGLHVKASGYKVIHVTGRLRAHALGLVALGHTLPPAPLAELPL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB7 HGHMIVFRLSLGLTILACESRVSDHMDLGPSELVGRSCYQFVHGQDATRIRQSHVDLLDK :::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 HGHMIVFRLSLGLTILACESRVSDHMDLGPSELVGRSCYQFVHGQDATRIRQSHVDSCRG 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB7 GQVMTGYYRWLQRAGGFVWLQSVATVAGSGKSPGEHHVLWVSHVLSQAEGGQTPLDAFQL XP_006 LRVAAVCGHSGWEREEPRGAPCALGQPRAQPSRGWPNSFGCLPASSQRGL 370 380 390 400 410 >>XP_016882331 (OMIM: 603346) PREDICTED: neuronal PAS do (650 aa) initn: 4012 init1: 2361 opt: 2361 Z-score: 1538.8 bits: 294.9 E(85289): 5.7e-79 Smith-Waterman score: 3686; 90.4% identity (90.4% similar) in 622 aa overlap (1-562:1-622) 10 20 30 40 50 60 pF1KB7 MAAPYPGSGGGSEVKCVGGRGASVPWDFLPGLMVKAPSGPCLQAQRKEKSRNAARSRRGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MAAPYPGSGGGSEVKCVGGRGASVPWDFLPGLMVKAPSGPCLQAQRKEKSRNAARSRRGK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 ENLEFFELAKLLPLPGAISSQLDKASIVRLSVTYLRLRRFAALGAPPWGLRAAGPPAGLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ENLEFFELAKLLPLPGAISSQLDKASIVRLSVTYLRLRRFAALGAPPWGLRAAGPPAGLA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 PGRRGPAALVSEVFEQHLGGHILQSLDGFVFALNQEGKFLYISETVSIYLGLSQVEMTGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PGRRGPAALVSEVFEQHLGGHILQSLDGFVFALNQEGKFLYISETVSIYLGLSQVEMTGS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 SVFDYIHPGDHSEVLEQLGLRTPTPGPPTPPSVSSSSSSSSSLADTPEIEASLTKVPPSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SVFDYIHPGDHSEVLEQLGLRTPTPGPPTPPSVSSSSSSSSSLADTPEIEASLTKVPPSS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB7 LVQERSFFVRMKSTLTKRGLHVKASGYKVIHVTGRLRAHALGLVALGHTLPPAPLAELPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LVQERSFFVRMKSTLTKRGLHVKASGYKVIHVTGRLRAHALGLVALGHTLPPAPLAELPL 250 260 270 280 290 300 310 320 330 340 350 pF1KB7 HGHMIVFRLSLGLTILACESRVSDHMDLGPSELVGRSCYQFVHGQDATRIRQSHVD---- :::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HGHMIVFRLSLGLTILACESRVSDHMDLGPSELVGRSCYQFVHGQDATRIRQSHVDCETH 310 320 330 340 350 360 360 pF1KB7 --------------------------------------------------------LLDK :::: XP_016 LHPPSLPTTPQTRASHSLVPGSPSSGLPTVPPAAPTAPGTPFSIGRAARRLSDASGLLDK 370 380 390 400 410 420 370 380 390 400 410 420 pF1KB7 GQVMTGYYRWLQRAGGFVWLQSVATVAGSGKSPGEHHVLWVSHVLSQAEGGQTPLDAFQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GQVMTGYYRWLQRAGGFVWLQSVATVAGSGKSPGEHHVLWVSHVLSQAEGGQTPLDAFQL 430 440 450 460 470 480 430 440 450 460 470 480 pF1KB7 PASVACEEASSPGPEPTEPEPPTEGKQAAPAENEAPQTQGKRIKVEPGPRETKGSEDSGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PASVACEEASSPGPEPTEPEPPTEGKQAAPAENEAPQTQGKRIKVEPGPRETKGSEDSGD 490 500 510 520 530 540 490 500 510 520 530 540 pF1KB7 EDPSSHPATPRPEFTSVIRAGVLKQDPVRPWGLAPPGDPPPTLLHAGFLPPVVRGLCTPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EDPSSHPATPRPEFTSVIRAGVLKQDPVRPWGLAPPGDPPPTLLHAGFLPPVVRGLCTPG 550 560 570 580 590 600 550 560 570 580 590 pF1KB7 TIRYGPAELGLVYPHLQRLGPGPALPEAFYPPLGLPYPGPAGTRLPRKGD :::::::::::::::::::::: XP_016 TIRYGPAELGLVYPHLQRLGPGPALPEAFYPPLGLPYPGPAGTRLPRKGD 610 620 630 640 650 >>XP_011525304 (OMIM: 603346) PREDICTED: neuronal PAS do (454 aa) initn: 1818 init1: 1769 opt: 2353 Z-score: 1535.7 bits: 293.8 E(85289): 8.5e-79 Smith-Waterman score: 2360; 83.4% identity (88.1% similar) in 453 aa overlap (1-451:1-437) 10 20 30 40 50 60 pF1KB7 MAAPYPGSGGGSEVKCVGGRGASVPWDFLPGLMVKAPSGPCLQAQRKEKSRNAARSRRGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MAAPYPGSGGGSEVKCVGGRGASVPWDFLPGLMVKAPSGPCLQAQRKEKSRNAARSRRGK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 ENLEFFELAKLLPLPGAISSQLDKASIVRLSVTYLRLRRFAALGAPPWGLRAAGPPAGLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ENLEFFELAKLLPLPGAISSQLDKASIVRLSVTYLRLRRFAALGAPPWGLRAAGPPAGLA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 PGRRGPAALVSEVFEQHLGGHILQSLDGFVFALNQEGKFLYISETVSIYLGLSQVEMTGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PGRRGPAALVSEVFEQHLGGHILQSLDGFVFALNQEGKFLYISETVSIYLGLSQVEMTGS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 SVFDYIHPGDHSEVLEQLGLRTPTPGPPTPPSVSSSSSSSSSLADTPEIEASLTKVPPSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SVFDYIHPGDHSEVLEQLGLRTPTPGPPTPPSVSSSSSSSSSLADTPEIEASLTKVPPSS 190 200 210 220 230 240 250 260 270 280 290 pF1KB7 LVQERSFFVRMKSTLTKRGLHVKASGYK-VIHVTGRLRAHALGLVALGHTLPPAPLAELP :::::::::::::::::::::::::::: ::::::::::::::::::::::::::::::: XP_011 LVQERSFFVRMKSTLTKRGLHVKASGYKQVIHVTGRLRAHALGLVALGHTLPPAPLAELP 250 260 270 280 290 300 300 310 320 330 340 350 pF1KB7 LHGHMIVFRLSLGLTILACESRVSDHMDLGPSELVGRSCYQFVHGQDATRIRQSHVDLLD ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: . XP_011 LHGHMIVFRLSLGLTILACESRVSDHMDLGPSELVGRSCYQFVHGQDATRIRQSHVD--S 310 320 330 340 350 360 370 380 390 400 410 pF1KB7 KGQVMTGYYRWLQRAGGFVWLQSVATVAGSGKSPGEHHVLWVSHVLSQAEGGQTPLDAFQ : .: . :. . .: : . :.:: :. : . .:.. : . XP_011 KPRV--AKLLWMPSSFQPAW--PVRRHPARGQSPQ-------SRSLRR-KGSRLPQRRTR 360 370 380 390 400 420 430 440 450 460 470 pF1KB7 LPASVACEEASSPGPEPTEPEPP-TEGKQAAPAENEAPQTQGKRIKVEPGPRETKGSEDS : : .::. .: .:. : : . . :: XP_011 PPRPRA--NASKWSPARGKPKAPRTVATRIPPATRPHRGPSSPLSSGQGS 410 420 430 440 450 480 490 500 510 520 530 pF1KB7 GDEDPSSHPATPRPEFTSVIRAGVLKQDPVRPWGLAPPGDPPPTLLHAGFLPPVVRGLCT >>XP_011525309 (OMIM: 603346) PREDICTED: neuronal PAS do (411 aa) initn: 1818 init1: 1769 opt: 2349 Z-score: 1533.7 bits: 293.2 E(85289): 1.1e-78 Smith-Waterman score: 2349; 99.7% identity (99.7% similar) in 357 aa overlap (1-356:1-357) 10 20 30 40 50 60 pF1KB7 MAAPYPGSGGGSEVKCVGGRGASVPWDFLPGLMVKAPSGPCLQAQRKEKSRNAARSRRGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MAAPYPGSGGGSEVKCVGGRGASVPWDFLPGLMVKAPSGPCLQAQRKEKSRNAARSRRGK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 ENLEFFELAKLLPLPGAISSQLDKASIVRLSVTYLRLRRFAALGAPPWGLRAAGPPAGLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ENLEFFELAKLLPLPGAISSQLDKASIVRLSVTYLRLRRFAALGAPPWGLRAAGPPAGLA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 PGRRGPAALVSEVFEQHLGGHILQSLDGFVFALNQEGKFLYISETVSIYLGLSQVEMTGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PGRRGPAALVSEVFEQHLGGHILQSLDGFVFALNQEGKFLYISETVSIYLGLSQVEMTGS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 SVFDYIHPGDHSEVLEQLGLRTPTPGPPTPPSVSSSSSSSSSLADTPEIEASLTKVPPSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SVFDYIHPGDHSEVLEQLGLRTPTPGPPTPPSVSSSSSSSSSLADTPEIEASLTKVPPSS 190 200 210 220 230 240 250 260 270 280 290 pF1KB7 LVQERSFFVRMKSTLTKRGLHVKASGYK-VIHVTGRLRAHALGLVALGHTLPPAPLAELP :::::::::::::::::::::::::::: ::::::::::::::::::::::::::::::: XP_011 LVQERSFFVRMKSTLTKRGLHVKASGYKQVIHVTGRLRAHALGLVALGHTLPPAPLAELP 250 260 270 280 290 300 300 310 320 330 340 350 pF1KB7 LHGHMIVFRLSLGLTILACESRVSDHMDLGPSELVGRSCYQFVHGQDATRIRQSHVDLLD ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LHGHMIVFRLSLGLTILACESRVSDHMDLGPSELVGRSCYQFVHGQDATRIRQSHVDSCR 310 320 330 340 350 360 360 370 380 390 400 410 pF1KB7 KGQVMTGYYRWLQRAGGFVWLQSVATVAGSGKSPGEHHVLWVSHVLSQAEGGQTPLDAFQ XP_011 GLRVAAVCGHSGWEREEPRGAPCALGQPRAQPSRGWPNSFGCLPASSQRGL 370 380 390 400 410 >>XP_011525308 (OMIM: 603346) PREDICTED: neuronal PAS do (411 aa) initn: 1818 init1: 1769 opt: 2349 Z-score: 1533.7 bits: 293.2 E(85289): 1.1e-78 Smith-Waterman score: 2349; 99.7% identity (99.7% similar) in 357 aa overlap (1-356:1-357) 10 20 30 40 50 60 pF1KB7 MAAPYPGSGGGSEVKCVGGRGASVPWDFLPGLMVKAPSGPCLQAQRKEKSRNAARSRRGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MAAPYPGSGGGSEVKCVGGRGASVPWDFLPGLMVKAPSGPCLQAQRKEKSRNAARSRRGK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 ENLEFFELAKLLPLPGAISSQLDKASIVRLSVTYLRLRRFAALGAPPWGLRAAGPPAGLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ENLEFFELAKLLPLPGAISSQLDKASIVRLSVTYLRLRRFAALGAPPWGLRAAGPPAGLA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 PGRRGPAALVSEVFEQHLGGHILQSLDGFVFALNQEGKFLYISETVSIYLGLSQVEMTGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PGRRGPAALVSEVFEQHLGGHILQSLDGFVFALNQEGKFLYISETVSIYLGLSQVEMTGS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 SVFDYIHPGDHSEVLEQLGLRTPTPGPPTPPSVSSSSSSSSSLADTPEIEASLTKVPPSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SVFDYIHPGDHSEVLEQLGLRTPTPGPPTPPSVSSSSSSSSSLADTPEIEASLTKVPPSS 190 200 210 220 230 240 250 260 270 280 290 pF1KB7 LVQERSFFVRMKSTLTKRGLHVKASGYK-VIHVTGRLRAHALGLVALGHTLPPAPLAELP :::::::::::::::::::::::::::: ::::::::::::::::::::::::::::::: XP_011 LVQERSFFVRMKSTLTKRGLHVKASGYKQVIHVTGRLRAHALGLVALGHTLPPAPLAELP 250 260 270 280 290 300 300 310 320 330 340 350 pF1KB7 LHGHMIVFRLSLGLTILACESRVSDHMDLGPSELVGRSCYQFVHGQDATRIRQSHVDLLD ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LHGHMIVFRLSLGLTILACESRVSDHMDLGPSELVGRSCYQFVHGQDATRIRQSHVDSCR 310 320 330 340 350 360 360 370 380 390 400 410 pF1KB7 KGQVMTGYYRWLQRAGGFVWLQSVATVAGSGKSPGEHHVLWVSHVLSQAEGGQTPLDAFQ XP_011 GLRVAAVCGHSGWEREEPRGAPCALGQPRAQPSRGWPNSFGCLPASSQRGL 370 380 390 400 410 >>XP_016882332 (OMIM: 603346) PREDICTED: neuronal PAS do (582 aa) initn: 2367 init1: 1769 opt: 2349 Z-score: 1531.7 bits: 293.4 E(85289): 1.4e-78 Smith-Waterman score: 2810; 77.0% identity (80.3% similar) in 600 aa overlap (1-535:1-579) 10 20 30 40 50 60 pF1KB7 MAAPYPGSGGGSEVKCVGGRGASVPWDFLPGLMVKAPSGPCLQAQRKEKSRNAARSRRGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MAAPYPGSGGGSEVKCVGGRGASVPWDFLPGLMVKAPSGPCLQAQRKEKSRNAARSRRGK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 ENLEFFELAKLLPLPGAISSQLDKASIVRLSVTYLRLRRFAALGAPPWGLRAAGPPAGLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ENLEFFELAKLLPLPGAISSQLDKASIVRLSVTYLRLRRFAALGAPPWGLRAAGPPAGLA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 PGRRGPAALVSEVFEQHLGGHILQSLDGFVFALNQEGKFLYISETVSIYLGLSQVEMTGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PGRRGPAALVSEVFEQHLGGHILQSLDGFVFALNQEGKFLYISETVSIYLGLSQVEMTGS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 SVFDYIHPGDHSEVLEQLGLRTPTPGPPTPPSVSSSSSSSSSLADTPEIEASLTKVPPSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SVFDYIHPGDHSEVLEQLGLRTPTPGPPTPPSVSSSSSSSSSLADTPEIEASLTKVPPSS 190 200 210 220 230 240 250 260 270 280 290 pF1KB7 LVQERSFFVRMKSTLTKRGLHVKASGYK-VIHVTGRLRAHALGLVALGHTLPPAPLAELP :::::::::::::::::::::::::::: ::::::::::::::::::::::::::::::: XP_016 LVQERSFFVRMKSTLTKRGLHVKASGYKQVIHVTGRLRAHALGLVALGHTLPPAPLAELP 250 260 270 280 290 300 300 310 320 330 340 350 pF1KB7 LHGHMIVFRLSLGLTILACESRVSDHMDLGPSELVGRSCYQFVHGQDATRIRQSHVD--- ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LHGHMIVFRLSLGLTILACESRVSDHMDLGPSELVGRSCYQFVHGQDATRIRQSHVDCET 310 320 330 340 350 360 pF1KB7 ---------------------------------------------------------LLD ::: XP_016 HLHPPSLPTTPQTRASHSLVPGSPSSGLPTVPPAAPTAPGTPFSIGRAARRLSDASGLLD 370 380 390 400 410 420 360 370 380 390 400 410 pF1KB7 KGQVMTGYYRWLQRAGGFVWLQSVATVAGSGKSPGEHHVLWVSHVLSQAEGGQTPLDAFQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KGQVMTGYYRWLQRAGGFVWLQSVATVAGSGKSPGEHHVLWVSHVLSQAEGGQTPLDAFQ 430 440 450 460 470 480 420 430 440 450 460 470 pF1KB7 LPASVACEEASSPGPEPTEPEPPTEGKQAAPAENEAPQTQGKRIKVEPGPRETKGSEDSG ::::::::::::::::::. . ::: .::. : . .... . .: XP_016 LPASVACEEASSPGPEPTDGK--TEGWG---------HTQALSIFLF----QSRSLRRKG 490 500 510 520 480 490 500 510 520 530 pF1KB7 DEDPSSHPATPRPEFTSVIRAGVLKQDPVRPWGLAP----PGDPPPTLLHAGFLPPVVRG .. :. . ::: ::.. : .:.: :: :: : : : :. : XP_016 SRLPQRRTRPPRP------RANASKWSPARGKPKAPRTVATRIPPATRPHRGPSSPLSSG 530 540 550 560 570 540 550 560 570 580 590 pF1KB7 LCTPGTIRYGPAELGLVYPHLQRLGPGPALPEAFYPPLGLPYPGPAGTRLPRKGD XP_016 QGS 580 >>XP_016882330 (OMIM: 603346) PREDICTED: neuronal PAS do (651 aa) initn: 3465 init1: 1769 opt: 2349 Z-score: 1531.0 bits: 293.4 E(85289): 1.5e-78 Smith-Waterman score: 3666; 90.2% identity (90.2% similar) in 622 aa overlap (1-561:1-622) 10 20 30 40 50 60 pF1KB7 MAAPYPGSGGGSEVKCVGGRGASVPWDFLPGLMVKAPSGPCLQAQRKEKSRNAARSRRGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MAAPYPGSGGGSEVKCVGGRGASVPWDFLPGLMVKAPSGPCLQAQRKEKSRNAARSRRGK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 ENLEFFELAKLLPLPGAISSQLDKASIVRLSVTYLRLRRFAALGAPPWGLRAAGPPAGLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ENLEFFELAKLLPLPGAISSQLDKASIVRLSVTYLRLRRFAALGAPPWGLRAAGPPAGLA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 PGRRGPAALVSEVFEQHLGGHILQSLDGFVFALNQEGKFLYISETVSIYLGLSQVEMTGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PGRRGPAALVSEVFEQHLGGHILQSLDGFVFALNQEGKFLYISETVSIYLGLSQVEMTGS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 SVFDYIHPGDHSEVLEQLGLRTPTPGPPTPPSVSSSSSSSSSLADTPEIEASLTKVPPSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SVFDYIHPGDHSEVLEQLGLRTPTPGPPTPPSVSSSSSSSSSLADTPEIEASLTKVPPSS 190 200 210 220 230 240 250 260 270 280 290 pF1KB7 LVQERSFFVRMKSTLTKRGLHVKASGYK-VIHVTGRLRAHALGLVALGHTLPPAPLAELP :::::::::::::::::::::::::::: ::::::::::::::::::::::::::::::: XP_016 LVQERSFFVRMKSTLTKRGLHVKASGYKQVIHVTGRLRAHALGLVALGHTLPPAPLAELP 250 260 270 280 290 300 300 310 320 330 340 350 pF1KB7 LHGHMIVFRLSLGLTILACESRVSDHMDLGPSELVGRSCYQFVHGQDATRIRQSHVD--- ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LHGHMIVFRLSLGLTILACESRVSDHMDLGPSELVGRSCYQFVHGQDATRIRQSHVDCET 310 320 330 340 350 360 pF1KB7 ---------------------------------------------------------LLD ::: XP_016 HLHPPSLPTTPQTRASHSLVPGSPSSGLPTVPPAAPTAPGTPFSIGRAARRLSDASGLLD 370 380 390 400 410 420 360 370 380 390 400 410 pF1KB7 KGQVMTGYYRWLQRAGGFVWLQSVATVAGSGKSPGEHHVLWVSHVLSQAEGGQTPLDAFQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KGQVMTGYYRWLQRAGGFVWLQSVATVAGSGKSPGEHHVLWVSHVLSQAEGGQTPLDAFQ 430 440 450 460 470 480 420 430 440 450 460 470 pF1KB7 LPASVACEEASSPGPEPTEPEPPTEGKQAAPAENEAPQTQGKRIKVEPGPRETKGSEDSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LPASVACEEASSPGPEPTEPEPPTEGKQAAPAENEAPQTQGKRIKVEPGPRETKGSEDSG 490 500 510 520 530 540 480 490 500 510 520 530 pF1KB7 DEDPSSHPATPRPEFTSVIRAGVLKQDPVRPWGLAPPGDPPPTLLHAGFLPPVVRGLCTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DEDPSSHPATPRPEFTSVIRAGVLKQDPVRPWGLAPPGDPPPTLLHAGFLPPVVRGLCTP 550 560 570 580 590 600 540 550 560 570 580 590 pF1KB7 GTIRYGPAELGLVYPHLQRLGPGPALPEAFYPPLGLPYPGPAGTRLPRKGD :::::::::::::::::::::: XP_016 GTIRYGPAELGLVYPHLQRLGPGPALPEAFYPPLGLPYPGPAGTRLPRKGD 610 620 630 640 650 590 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 04:40:19 2016 done: Sun Nov 6 04:40:21 2016 Total Scan time: 12.220 Total Display time: 0.090 Function used was FASTA [36.3.4 Apr, 2011]