FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE2481, 472 aa 1>>>pF1KE2481 472 - 472 aa - 472 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 9.6424+/-0.000344; mu= -1.6400+/- 0.022 mean_var=210.3542+/-43.109, 0's: 0 Z-trim(121.9): 29 B-trim: 356 in 1/54 Lambda= 0.088430 statistics sampled from 39265 (39294) to 39265 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.782), E-opt: 0.2 (0.461), width: 16 Scan time: 11.460 The best scores are: opt bits E(85289) NP_996783 (OMIM: 603183,604805) reticulon-2 isofor ( 472) 3097 407.5 4.2e-113 NP_005610 (OMIM: 603183,604805) reticulon-2 isofor ( 545) 1850 248.4 3.7e-65 NP_996784 (OMIM: 603183,604805) reticulon-2 isofor ( 205) 1249 171.5 1.9e-42 NP_066959 (OMIM: 600865) reticulon-1 isoform A [Ho ( 776) 695 101.1 1.1e-20 NP_997403 (OMIM: 604475) reticulon-4 isoform D [Ho ( 392) 676 98.6 3.4e-20 XP_016877067 (OMIM: 600865) PREDICTED: reticulon-1 ( 193) 647 94.7 2.4e-19 NP_996734 (OMIM: 600865) reticulon-1 isoform C [Ho ( 208) 640 93.8 4.8e-19 NP_722550 (OMIM: 604475) reticulon-4 isoform B [Ho ( 373) 631 92.8 1.7e-18 NP_001308790 (OMIM: 604475) reticulon-4 isoform E ( 986) 626 92.4 6.2e-18 NP_001308791 (OMIM: 604475) reticulon-4 isoform E ( 986) 626 92.4 6.2e-18 NP_001308833 (OMIM: 604475) reticulon-4 isoform E ( 986) 626 92.4 6.2e-18 NP_001308792 (OMIM: 604475) reticulon-4 isoform E ( 986) 626 92.4 6.2e-18 NP_997404 (OMIM: 604475) reticulon-4 isoform E [Ho ( 986) 626 92.4 6.2e-18 XP_016860007 (OMIM: 604475) PREDICTED: reticulon-4 ( 986) 626 92.4 6.2e-18 NP_001308789 (OMIM: 604475) reticulon-4 isoform E ( 986) 626 92.4 6.2e-18 XP_005264491 (OMIM: 604475) PREDICTED: reticulon-4 ( 986) 626 92.4 6.2e-18 XP_016860008 (OMIM: 604475) PREDICTED: reticulon-4 ( 986) 626 92.4 6.2e-18 NP_001308788 (OMIM: 604475) reticulon-4 isoform E ( 986) 626 92.4 6.2e-18 NP_065393 (OMIM: 604475) reticulon-4 isoform A [Ho (1192) 626 92.4 7.3e-18 NP_008939 (OMIM: 604475) reticulon-4 isoform C [Ho ( 199) 606 89.5 9.3e-18 NP_958832 (OMIM: 604249) reticulon-3 isoform c [Ho ( 255) 563 84.0 5.1e-16 NP_006045 (OMIM: 604249) reticulon-3 isoform a [Ho ( 236) 558 83.4 7.5e-16 NP_001252519 (OMIM: 604249) reticulon-3 isoform f ( 920) 569 85.1 9e-16 NP_958831 (OMIM: 604249) reticulon-3 isoform b [Ho (1013) 569 85.1 9.8e-16 NP_001252518 (OMIM: 604249) reticulon-3 isoform e (1032) 569 85.1 1e-15 XP_011543033 (OMIM: 604249) PREDICTED: reticulon-3 ( 260) 469 72.1 2.1e-12 NP_958833 (OMIM: 604249) reticulon-3 isoform d [Ho ( 241) 464 71.4 3.1e-12 XP_011543032 (OMIM: 604249) PREDICTED: reticulon-3 (1037) 475 73.1 4.1e-12 NP_001252520 (OMIM: 604249) reticulon-3 isoform g ( 214) 217 39.9 0.0086 >>NP_996783 (OMIM: 603183,604805) reticulon-2 isoform B (472 aa) initn: 3097 init1: 3097 opt: 3097 Z-score: 2151.6 bits: 407.5 E(85289): 4.2e-113 Smith-Waterman score: 3097; 100.0% identity (100.0% similar) in 472 aa overlap (1-472:1-472) 10 20 30 40 50 60 pF1KE2 MGQVLPVFAHCKEAPSTASSTPDSTEGGNDDSDFRELHTAREFSEEDEEETTSQDWGTPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_996 MGQVLPVFAHCKEAPSTASSTPDSTEGGNDDSDFRELHTAREFSEEDEEETTSQDWGTPR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 ELTFSYIAFDGVVGSGGRRDSTARRPRPQGRSVSEPRDQHPQPSLGDSLESIPSLSQSPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_996 ELTFSYIAFDGVVGSGGRRDSTARRPRPQGRSVSEPRDQHPQPSLGDSLESIPSLSQSPE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 PGRRGDPDTAPPSERPLEDLRLRLDHLGWVARGTGSGEDSSTSSSTPLEDEEPQEPNRLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_996 PGRRGDPDTAPPSERPLEDLRLRLDHLGWVARGTGSGEDSSTSSSTPLEDEEPQEPNRLE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 TGEAGEELDLRLRLAQPSSPEVLTPQLSPGSGTPQAGTPSPSRSRDSNSGPEEPLLEEEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_996 TGEAGEELDLRLRLAQPSSPEVLTPQLSPGSGTPQAGTPSPSRSRDSNSGPEEPLLEEEE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 KQWGPLEREPVRGQCLDSTDQLEFTVEPRLLVADLLYWKDTRTSGVVFTGLMVSLLCLLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_996 KQWGPLEREPVRGQCLDSTDQLEFTVEPRLLVADLLYWKDTRTSGVVFTGLMVSLLCLLH 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 FSIVSVAAHLALLLLCGTISLRVYRKVLQAVHRGDGANPFQAYLDVDLTLTREQTERLSH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_996 FSIVSVAAHLALLLLCGTISLRVYRKVLQAVHRGDGANPFQAYLDVDLTLTREQTERLSH 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 QITSRVVSAATQLRHFFLVEDLVDSLKLALLFYILTFVGAIFNGLTLLILGVIGLFTIPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_996 QITSRVVSAATQLRHFFLVEDLVDSLKLALLFYILTFVGAIFNGLTLLILGVIGLFTIPL 370 380 390 400 410 420 430 440 450 460 470 pF1KE2 LYRQHQAQIDQYVGLVTNQLSHIKAKIRAKIPGTGALASAAAAVSGSKAKAE :::::::::::::::::::::::::::::::::::::::::::::::::::: NP_996 LYRQHQAQIDQYVGLVTNQLSHIKAKIRAKIPGTGALASAAAAVSGSKAKAE 430 440 450 460 470 >>NP_005610 (OMIM: 603183,604805) reticulon-2 isoform A (545 aa) initn: 1849 init1: 1849 opt: 1850 Z-score: 1290.8 bits: 248.4 E(85289): 3.7e-65 Smith-Waterman score: 2699; 85.5% identity (85.5% similar) in 504 aa overlap (1-431:1-504) 10 20 30 40 50 60 pF1KE2 MGQVLPVFAHCKEAPSTASSTPDSTEGGNDDSDFRELHTAREFSEEDEEETTSQDWGTPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 MGQVLPVFAHCKEAPSTASSTPDSTEGGNDDSDFRELHTAREFSEEDEEETTSQDWGTPR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 ELTFSYIAFDGVVGSGGRRDSTARRPRPQGRSVSEPRDQHPQPSLGDSLESIPSLSQSPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 ELTFSYIAFDGVVGSGGRRDSTARRPRPQGRSVSEPRDQHPQPSLGDSLESIPSLSQSPE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 PGRRGDPDTAPPSERPLEDLRLRLDHLGWVARGTGSGEDSSTSSSTPLEDEEPQEPNRLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 PGRRGDPDTAPPSERPLEDLRLRLDHLGWVARGTGSGEDSSTSSSTPLEDEEPQEPNRLE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 TGEAGEELDLRLRLAQPSSPEVLTPQLSPGSGTPQAGTPSPSRSRDSNSGPEEPLLEEEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 TGEAGEELDLRLRLAQPSSPEVLTPQLSPGSGTPQAGTPSPSRSRDSNSGPEEPLLEEEE 190 200 210 220 230 240 250 260 270 pF1KE2 KQWGPLEREPVRGQCLDSTDQLEFTVEPRLL----------------------------- ::::::::::::::::::::::::::::::: NP_005 KQWGPLEREPVRGQCLDSTDQLEFTVEPRLLGTAMEWLKTSLLLAVYKTVPILELSPPLW 250 260 270 280 290 300 280 pF1KE2 --------------------------------------------VADLLYWKDTRTSGVV :::::::::::::::: NP_005 TAIGWVQRGPTPPTPVLRVLLKWAKSPRSSGVPSLSLGADMGSKVADLLYWKDTRTSGVV 310 320 330 340 350 360 290 300 310 320 330 340 pF1KE2 FTGLMVSLLCLLHFSIVSVAAHLALLLLCGTISLRVYRKVLQAVHRGDGANPFQAYLDVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 FTGLMVSLLCLLHFSIVSVAAHLALLLLCGTISLRVYRKVLQAVHRGDGANPFQAYLDVD 370 380 390 400 410 420 350 360 370 380 390 400 pF1KE2 LTLTREQTERLSHQITSRVVSAATQLRHFFLVEDLVDSLKLALLFYILTFVGAIFNGLTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 LTLTREQTERLSHQITSRVVSAATQLRHFFLVEDLVDSLKLALLFYILTFVGAIFNGLTL 430 440 450 460 470 480 410 420 430 440 450 460 pF1KE2 LILGVIGLFTIPLLYRQHQAQIDQYVGLVTNQLSHIKAKIRAKIPGTGALASAAAAVSGS :::::::::::::::::::::::: NP_005 LILGVIGLFTIPLLYRQHQAQIDQYVGLVTNQLSHIKAKIRAKIPGTGALASAAAAVSGS 490 500 510 520 530 540 >>NP_996784 (OMIM: 603183,604805) reticulon-2 isoform C (205 aa) initn: 1249 init1: 1249 opt: 1249 Z-score: 883.0 bits: 171.5 E(85289): 1.9e-42 Smith-Waterman score: 1249; 100.0% identity (100.0% similar) in 201 aa overlap (272-472:5-205) 250 260 270 280 290 300 pF1KE2 QWGPLEREPVRGQCLDSTDQLEFTVEPRLLVADLLYWKDTRTSGVVFTGLMVSLLCLLHF :::::::::::::::::::::::::::::: NP_996 MGSKVADLLYWKDTRTSGVVFTGLMVSLLCLLHF 10 20 30 310 320 330 340 350 360 pF1KE2 SIVSVAAHLALLLLCGTISLRVYRKVLQAVHRGDGANPFQAYLDVDLTLTREQTERLSHQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_996 SIVSVAAHLALLLLCGTISLRVYRKVLQAVHRGDGANPFQAYLDVDLTLTREQTERLSHQ 40 50 60 70 80 90 370 380 390 400 410 420 pF1KE2 ITSRVVSAATQLRHFFLVEDLVDSLKLALLFYILTFVGAIFNGLTLLILGVIGLFTIPLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_996 ITSRVVSAATQLRHFFLVEDLVDSLKLALLFYILTFVGAIFNGLTLLILGVIGLFTIPLL 100 110 120 130 140 150 430 440 450 460 470 pF1KE2 YRQHQAQIDQYVGLVTNQLSHIKAKIRAKIPGTGALASAAAAVSGSKAKAE ::::::::::::::::::::::::::::::::::::::::::::::::::: NP_996 YRQHQAQIDQYVGLVTNQLSHIKAKIRAKIPGTGALASAAAAVSGSKAKAE 160 170 180 190 200 >>NP_066959 (OMIM: 600865) reticulon-1 isoform A [Homo s (776 aa) initn: 723 init1: 640 opt: 695 Z-score: 492.1 bits: 101.1 E(85289): 1.1e-20 Smith-Waterman score: 714; 36.6% identity (63.1% similar) in 407 aa overlap (83-453:381-770) 60 70 80 90 100 pF1KE2 SQDWGTPRELTFSYIAFDGVVGSGGRRDSTARRPRPQGRS----VSEPRDQHPQPSL-GD : ::. ..:: . : :.. . . :: NP_066 ISEDELITAIKEAKGLSYETAENPRPVGQLADRPEVKARSGPPTIPSPLDHEASSAESGD 360 370 380 390 400 410 110 120 130 140 150 pF1KE2 S-LESI---PSLSQSPEP------GRRGDPDTAPPSERPL-----EDLRLRLDHLGWVAR : .: . : ... : :. : : .: : :. . .:: . NP_066 SEIELVSEDPMAAEDALPSGYVSFGHVGGPPPSPASPSIQYSILREEREAELDSELIIE- 420 430 440 450 460 160 170 180 190 200 pF1KE2 GTGSGEDSSTSSSTPL--EDEEPQEPN-----RLETG-EAGEELDLRLRLAQPSS----P : . ::.: .: .: :..:. : ::: .: :. : ::.:.: : NP_066 ---SCDASSASEESPKREQDSPPMKPSALDAIREETGVRAEERAPSRRGLAEPGSFLDYP 470 480 490 500 510 520 210 220 230 240 250 pF1KE2 EVLT---PQLSPGSGTPQAGTPS-PSRSRDSNSGPEEPLLEEEEKQWGPLEREPVRGQCL . :.: ::.:. . :: : . ....:. . : . :: : NP_066 STEPQPGPELPPGDGALEPETPMLPRKPEEDSSSNQSPAATKGPGPLGPGAPPP------ 530 540 550 560 570 580 260 270 280 290 300 310 pF1KE2 DSTDQLEFTVEPRLLVADLLYWKDTRTSGVVFTGLMVSLLCLLHFSIVSVAAHLALLLLC : : . . . :::::.: . .:.:: .... :. : .::.:::.:.::: : NP_066 -----LLFLNKQKAI--DLLYWRDIKQTGIVFGSFLLLLFSLTQFSVVSVVAYLALAALS 590 600 610 620 630 320 330 340 350 360 370 pF1KE2 GTISLRVYRKVLQAVHRGDGANPFQAYLDVDLTLTREQTERLSHQITSRVVSAATQLRHF .:::.:.:..:::::.. : ..::.:::....::..:: .. . . : :. .::.. NP_066 ATISFRIYKSVLQAVQKTDEGHPFKAYLELEITLSQEQIQKYTDCLQFYVNSTLKELRRL 640 650 660 670 680 690 380 390 400 410 420 430 pF1KE2 FLVEDLVDSLKLALLFYILTFVGAIFNGLTLLILGVIGLFTIPLLYRQHQAQIDQYVGLV :::.:::::::.:.:...::.:::.:::::::...:...::.:..: .::::::::.::: NP_066 FLVQDLVDSLKFAVLMWLLTYVGALFNGLTLLLMAVVSMFTLPVVYVKHQAQIDQYLGLV 700 710 720 730 740 750 440 450 460 470 pF1KE2 TNQLSHIKAKIRAKIPGTGALASAAAAVSGSKAKAE .... . :::.::::: NP_066 RTHINAVVAKIQAKIPGAKRHAE 760 770 >>NP_997403 (OMIM: 604475) reticulon-4 isoform D [Homo s (392 aa) initn: 652 init1: 606 opt: 676 Z-score: 483.6 bits: 98.6 E(85289): 3.4e-20 Smith-Waterman score: 679; 35.5% identity (62.2% similar) in 394 aa overlap (81-453:12-386) 60 70 80 90 100 pF1KE2 TTSQDWGTPRELTFSYIAFDGVVGSGGRRDSTARRPRPQG----RSVSEPRDQHPQP--- :. :::: . : ::.:.. . NP_997 MEDLDQSPLVSSSDSPPRPQPAFKYQFVREPEDEEEEEEEE 10 20 30 40 110 120 130 140 150 160 pF1KE2 --SLGDSLESIPSLSQSPEPGRRGDP-DTAPPSERPLEDLRLRLDHLGWVARGTGSGEDS . ..:: . : ..: : . : ::: . :: :. : . . :: NP_997 EEDEDEDLEELEVLERKPAAGLSAAPVPTAPAAGAPLMDFG--NDFVPPAPRG------- 50 60 70 80 90 170 180 190 200 210 220 pF1KE2 STSSSTPLEDEEPQEPNRLETGEAGEELDLRLRLAQPSSPEVLTPQLSPGSGTPQAGTPS :: : :.: . . . .. . .: : ...:. : . : : : NP_997 ------PLPAAPPVAPERQPSWDPSP-VSSTVPAPSPLSAAAVSPSKLPEDDEPPARPPP 100 110 120 130 140 230 240 250 260 270 pF1KE2 PSRSRDSNSGPEEPLLEEEEKQWGPLEREPV----RGQCLDSTDQLEFTV----EPRL-- : . : : ::. . :. ::. :.:. :.. :: . NP_997 PPPA--SVSPQAEPVWTPPAPAPAAPPSTPAAPKRRGSS-GSVDETLFALPAASEPVIRS 150 160 170 180 190 200 280 290 300 310 320 pF1KE2 -LVADLLYWKDTRTSGVVFTGLMVSLLCLLHFSIVSVAAHLALLLLCGTISLRVYRKVLQ :.:::::.: . .:::: . . :: : ::::::.:..:: :: :::.:.:. :.: NP_997 SAVVDLLYWRDIKKTGVVFGASLFLLLSLTVFSIVSVTAYIALALLSVTISFRIYKGVIQ 210 220 230 240 250 260 330 340 350 360 370 380 pF1KE2 AVHRGDGANPFQAYLDVDLTLTREQTERLSHQITSRVVSAATQLRHFFLVEDLVDSLKLA :....: ..::.:::. ......: ... :.. ..: . .::..:::.:::::::.: NP_997 AIQKSDEGHPFRAYLESEVAISEELVQKYSNSALGHVNCTIKELRRLFLVDDLVDSLKFA 270 280 290 300 310 320 390 400 410 420 430 440 pF1KE2 LLFYILTFVGAIFNGLTLLILGVIGLFTIPLLYRQHQAQIDQYVGLVTNQLSHIKAKIRA .:....:.:::.:::::::::..:.::..:..:..::::::.:.::...... :::.: NP_997 VLMWVFTYVGALFNGLTLLILALISLFSVPVIYERHQAQIDHYLGLANKNVKDAMAKIQA 330 340 350 360 370 380 450 460 470 pF1KE2 KIPGTGALASAAAAVSGSKAKAE :::: NP_997 KIPGLKRKAE 390 >>XP_016877067 (OMIM: 600865) PREDICTED: reticulon-1 iso (193 aa) initn: 640 init1: 640 opt: 647 Z-score: 468.3 bits: 94.7 E(85289): 2.4e-19 Smith-Waterman score: 647; 51.1% identity (84.9% similar) in 186 aa overlap (268-453:2-187) 240 250 260 270 280 290 pF1KE2 EEEKQWGPLEREPVRGQCLDSTDQLEFTVEPRLLVADLLYWKDTRTSGVVFTGLMVSLLC : : . :::::.: . .:.:: .... :. XP_016 MPFLPAIDLLYWRDIKQTGIVFGSFLLLLFS 10 20 30 300 310 320 330 340 350 pF1KE2 LLHFSIVSVAAHLALLLLCGTISLRVYRKVLQAVHRGDGANPFQAYLDVDLTLTREQTER : .::.:::.:.::: : .:::.:.:..:::::.. : ..::.:::....::..:: .. XP_016 LTQFSVVSVVAYLALAALSATISFRIYKSVLQAVQKTDEGHPFKAYLELEITLSQEQIQK 40 50 60 70 80 90 360 370 380 390 400 410 pF1KE2 LSHQITSRVVSAATQLRHFFLVEDLVDSLKLALLFYILTFVGAIFNGLTLLILGVIGLFT . . : :. .::..:::.:::::::.:.:...::.:::.:::::::...:...:: XP_016 YTDCLQFYVNSTLKELRRLFLVQDLVDSLKFAVLMWLLTYVGALFNGLTLLLMAVVSMFT 100 110 120 130 140 150 420 430 440 450 460 470 pF1KE2 IPLLYRQHQAQIDQYVGLVTNQLSHIKAKIRAKIPGTGALASAAAAVSGSKAKAE .:..: .::::::::.::: .... . :::.::::: XP_016 LPVVYVKHQAQIDQYLGLVRTHINAVVAKIQAKIPGAKRHAE 160 170 180 190 >>NP_996734 (OMIM: 600865) reticulon-1 isoform C [Homo s (208 aa) initn: 640 init1: 640 opt: 640 Z-score: 463.0 bits: 93.8 E(85289): 4.8e-19 Smith-Waterman score: 640; 51.7% identity (86.1% similar) in 180 aa overlap (274-453:23-202) 250 260 270 280 290 300 pF1KE2 GPLEREPVRGQCLDSTDQLEFTVEPRLLVADLLYWKDTRTSGVVFTGLMVSLLCLLHFSI :::::.: . .:.:: .... :. : .::. NP_996 MQATADSTKMDCVWSNWKSQAIDLLYWRDIKQTGIVFGSFLLLLFSLTQFSV 10 20 30 40 50 310 320 330 340 350 360 pF1KE2 VSVAAHLALLLLCGTISLRVYRKVLQAVHRGDGANPFQAYLDVDLTLTREQTERLSHQIT :::.:.::: : .:::.:.:..:::::.. : ..::.:::....::..:: .. . . NP_996 VSVVAYLALAALSATISFRIYKSVLQAVQKTDEGHPFKAYLELEITLSQEQIQKYTDCLQ 60 70 80 90 100 110 370 380 390 400 410 420 pF1KE2 SRVVSAATQLRHFFLVEDLVDSLKLALLFYILTFVGAIFNGLTLLILGVIGLFTIPLLYR : :. .::..:::.:::::::.:.:...::.:::.:::::::...:...::.:..: NP_996 FYVNSTLKELRRLFLVQDLVDSLKFAVLMWLLTYVGALFNGLTLLLMAVVSMFTLPVVYV 120 130 140 150 160 170 430 440 450 460 470 pF1KE2 QHQAQIDQYVGLVTNQLSHIKAKIRAKIPGTGALASAAAAVSGSKAKAE .::::::::.::: .... . :::.::::: NP_996 KHQAQIDQYLGLVRTHINAVVAKIQAKIPGAKRHAE 180 190 200 >>NP_722550 (OMIM: 604475) reticulon-4 isoform B [Homo s (373 aa) initn: 653 init1: 607 opt: 631 Z-score: 452.9 bits: 92.8 E(85289): 1.7e-18 Smith-Waterman score: 677; 34.7% identity (61.9% similar) in 383 aa overlap (81-453:12-367) 60 70 80 90 100 pF1KE2 TTSQDWGTPRELTFSYIAFDGVVGSGGRRDSTARRPRPQG----RSVSEPRDQHPQP--- :. :::: . : ::.:.. . NP_722 MEDLDQSPLVSSSDSPPRPQPAFKYQFVREPEDEEEEEEEE 10 20 30 40 110 120 130 140 150 160 pF1KE2 --SLGDSLESIPSLSQSPEPGRRGDP-DTAPPSERPLEDLRLRLDHLGWVARGTGSGEDS . ..:: . : ..: : . : ::: . :: :. : . . :: NP_722 EEDEDEDLEELEVLERKPAAGLSAAPVPTAPAAGAPLMDFG--NDFVPPAPRG------- 50 60 70 80 90 170 180 190 200 210 220 pF1KE2 STSSSTPLEDEEPQEPNRLETGEAGEELDLRLRLAQPSSPEVLTPQLSPGSGTPQAGTPS :: : :.: . . . .. . .: : ...:. : . : : : NP_722 ------PLPAAPPVAPERQPSWDPSP-VSSTVPAPSPLSAAAVSPSKLPEDDEPPARPPP 100 110 120 130 140 230 240 250 260 270 280 pF1KE2 PSRSRDSNSGPEEPLLEEEEKQWGPLEREPVRGQCLDSTDQLEFTVEPRLLVADLLYWKD : : . . : : : :. .. . . . .:.:::::.: NP_722 P---------PPASVSPQAEPVWTPPAPAPAAPPSTPAAPKRRGSSGS--VVVDLLYWRD 150 160 170 180 190 290 300 310 320 330 340 pF1KE2 TRTSGVVFTGLMVSLLCLLHFSIVSVAAHLALLLLCGTISLRVYRKVLQAVHRGDGANPF . .:::: . . :: : ::::::.:..:: :: :::.:.:. :.::....: ..:: NP_722 IKKTGVVFGASLFLLLSLTVFSIVSVTAYIALALLSVTISFRIYKGVIQAIQKSDEGHPF 200 210 220 230 240 250 350 360 370 380 390 400 pF1KE2 QAYLDVDLTLTREQTERLSHQITSRVVSAATQLRHFFLVEDLVDSLKLALLFYILTFVGA .:::. ......: ... :.. ..: . .::..:::.:::::::.:.:....:.::: NP_722 RAYLESEVAISEELVQKYSNSALGHVNCTIKELRRLFLVDDLVDSLKFAVLMWVFTYVGA 260 270 280 290 300 310 410 420 430 440 450 460 pF1KE2 IFNGLTLLILGVIGLFTIPLLYRQHQAQIDQYVGLVTNQLSHIKAKIRAKIPGTGALASA .:::::::::..:.::..:..:..::::::.:.::...... :::.::::: NP_722 LFNGLTLLILALISLFSVPVIYERHQAQIDHYLGLANKNVKDAMAKIQAKIPGLKRKAE 320 330 340 350 360 370 470 pF1KE2 AAAVSGSKAKAE >>NP_001308790 (OMIM: 604475) reticulon-4 isoform E [Hom (986 aa) initn: 606 init1: 606 opt: 626 Z-score: 443.0 bits: 92.4 E(85289): 6.2e-18 Smith-Waterman score: 626; 40.1% identity (74.0% similar) in 269 aa overlap (189-453:712-980) 160 170 180 190 200 210 pF1KE2 DSSTSSSTPLEDEEPQEPNRLETGEAGEELDLRLRLAQPSSPEVLT--PQLSP-GSGTPQ :: :. ::. : .. ..: ::.: . NP_001 EYTDLEVSHKSEIANAPDGAGSLPCTELPHDLSLKNIQPKVEEKISFSDDFSKNGSATSK 690 700 710 720 730 740 220 230 240 250 260 270 pF1KE2 AGTPSPSRSRDSNSGPEEPLLEEEEKQWGPLEREPVRGQCLDSTDQLEFTVE-PRLLVAD . :. : .... : ... . .. : . : . . :..: . :.: NP_001 VLLLPPDVSALATQAEIESIVKPKVLVKEAEKKLPSDTEKEDRSPSAIFSAELSKTSVVD 750 760 770 780 790 800 280 290 300 310 320 330 pF1KE2 LLYWKDTRTSGVVFTGLMVSLLCLLHFSIVSVAAHLALLLLCGTISLRVYRKVLQAVHRG ::::.: . .:::: . . :: : ::::::.:..:: :: :::.:.:. :.::.... NP_001 LLYWRDIKKTGVVFGASLFLLLSLTVFSIVSVTAYIALALLSVTISFRIYKGVIQAIQKS 810 820 830 840 850 860 340 350 360 370 380 390 pF1KE2 DGANPFQAYLDVDLTLTREQTERLSHQITSRVVSAATQLRHFFLVEDLVDSLKLALLFYI : ..::.:::. ......: ... :.. ..: . .::..:::.:::::::.:.:... NP_001 DEGHPFRAYLESEVAISEELVQKYSNSALGHVNCTIKELRRLFLVDDLVDSLKFAVLMWV 870 880 890 900 910 920 400 410 420 430 440 450 pF1KE2 LTFVGAIFNGLTLLILGVIGLFTIPLLYRQHQAQIDQYVGLVTNQLSHIKAKIRAKIPGT .:.:::.:::::::::..:.::..:..:..::::::.:.::...... :::.::::: NP_001 FTYVGALFNGLTLLILALISLFSVPVIYERHQAQIDHYLGLANKNVKDAMAKIQAKIPGL 930 940 950 960 970 980 460 470 pF1KE2 GALASAAAAVSGSKAKAE NP_001 KRKAE >>NP_001308791 (OMIM: 604475) reticulon-4 isoform E [Hom (986 aa) initn: 606 init1: 606 opt: 626 Z-score: 443.0 bits: 92.4 E(85289): 6.2e-18 Smith-Waterman score: 626; 40.1% identity (74.0% similar) in 269 aa overlap (189-453:712-980) 160 170 180 190 200 210 pF1KE2 DSSTSSSTPLEDEEPQEPNRLETGEAGEELDLRLRLAQPSSPEVLT--PQLSP-GSGTPQ :: :. ::. : .. ..: ::.: . NP_001 EYTDLEVSHKSEIANAPDGAGSLPCTELPHDLSLKNIQPKVEEKISFSDDFSKNGSATSK 690 700 710 720 730 740 220 230 240 250 260 270 pF1KE2 AGTPSPSRSRDSNSGPEEPLLEEEEKQWGPLEREPVRGQCLDSTDQLEFTVE-PRLLVAD . :. : .... : ... . .. : . : . . :..: . :.: NP_001 VLLLPPDVSALATQAEIESIVKPKVLVKEAEKKLPSDTEKEDRSPSAIFSAELSKTSVVD 750 760 770 780 790 800 280 290 300 310 320 330 pF1KE2 LLYWKDTRTSGVVFTGLMVSLLCLLHFSIVSVAAHLALLLLCGTISLRVYRKVLQAVHRG ::::.: . .:::: . . :: : ::::::.:..:: :: :::.:.:. :.::.... NP_001 LLYWRDIKKTGVVFGASLFLLLSLTVFSIVSVTAYIALALLSVTISFRIYKGVIQAIQKS 810 820 830 840 850 860 340 350 360 370 380 390 pF1KE2 DGANPFQAYLDVDLTLTREQTERLSHQITSRVVSAATQLRHFFLVEDLVDSLKLALLFYI : ..::.:::. ......: ... :.. ..: . .::..:::.:::::::.:.:... NP_001 DEGHPFRAYLESEVAISEELVQKYSNSALGHVNCTIKELRRLFLVDDLVDSLKFAVLMWV 870 880 890 900 910 920 400 410 420 430 440 450 pF1KE2 LTFVGAIFNGLTLLILGVIGLFTIPLLYRQHQAQIDQYVGLVTNQLSHIKAKIRAKIPGT .:.:::.:::::::::..:.::..:..:..::::::.:.::...... :::.::::: NP_001 FTYVGALFNGLTLLILALISLFSVPVIYERHQAQIDHYLGLANKNVKDAMAKIQAKIPGL 930 940 950 960 970 980 460 470 pF1KE2 GALASAAAAVSGSKAKAE NP_001 KRKAE 472 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 20:42:43 2016 done: Mon Nov 7 20:42:45 2016 Total Scan time: 11.460 Total Display time: 0.040 Function used was FASTA [36.3.4 Apr, 2011]