FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE1692, 200 aa 1>>>pF1KE1692 200 - 200 aa - 200 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.9411+/-0.000284; mu= 16.3861+/- 0.018 mean_var=72.3257+/-14.343, 0's: 0 Z-trim(119.8): 5 B-trim: 404 in 1/53 Lambda= 0.150809 statistics sampled from 34151 (34156) to 34151 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.777), E-opt: 0.2 (0.4), width: 16 Scan time: 5.990 The best scores are: opt bits E(85289) NP_742152 (OMIM: 607403) interferon lambda-1 precu ( 200) 1337 299.1 3.2e-81 NP_742151 (OMIM: 607402,609532) interferon lambda- ( 196) 899 203.8 1.5e-52 XP_005258822 (OMIM: 607402,609532) PREDICTED: inte ( 200) 899 203.8 1.5e-52 NP_742150 (OMIM: 607401) interferon lambda-2 [Homo ( 200) 884 200.5 1.5e-51 NP_001263183 (OMIM: 615090) interferon lambda-4 pr ( 179) 138 38.2 0.0099 >>NP_742152 (OMIM: 607403) interferon lambda-1 precursor (200 aa) initn: 1337 init1: 1337 opt: 1337 Z-score: 1579.2 bits: 299.1 E(85289): 3.2e-81 Smith-Waterman score: 1337; 100.0% identity (100.0% similar) in 200 aa overlap (1-200:1-200) 10 20 30 40 50 60 pF1KE1 MAAAWTVVLVTLVLGLAVAGPVPTSKPTTTGKGCHIGRFKSLSPQELASFKKARDALEES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_742 MAAAWTVVLVTLVLGLAVAGPVPTSKPTTTGKGCHIGRFKSLSPQELASFKKARDALEES 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 LKLKNWSCSSPVFPGNWDLRLLQVRERPVALEAELALTLKVLEAAAGPALEDVLDQPLHT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_742 LKLKNWSCSSPVFPGNWDLRLLQVRERPVALEAELALTLKVLEAAAGPALEDVLDQPLHT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 LHHILSQLQACIQPQPTAGPRPRGRLHHWLHRLQEAPKKESAGCLEASVTFNLFRLLTRD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_742 LHHILSQLQACIQPQPTAGPRPRGRLHHWLHRLQEAPKKESAGCLEASVTFNLFRLLTRD 130 140 150 160 170 180 190 200 pF1KE1 LKYVADGNLCLRTSTHPEST :::::::::::::::::::: NP_742 LKYVADGNLCLRTSTHPEST 190 200 >>NP_742151 (OMIM: 607402,609532) interferon lambda-3 pr (196 aa) initn: 948 init1: 521 opt: 899 Z-score: 1064.3 bits: 203.8 E(85289): 1.5e-52 Smith-Waterman score: 899; 74.1% identity (86.8% similar) in 189 aa overlap (8-191:8-196) 10 20 30 40 50 pF1KE1 MAAAWTVVLVTLVLGLAVAGPVPTSK---PTTTGKGCHIGRFKSLSPQELASFKKARDAL ::: .. :.:.: ::... ..::::..::::::::: .::.:.::: NP_742 MTGDCMPVLVLMAAVLTVTGAVPVARLRGALPDARGCHIAQFKSLSPQELQAFKRAKDAL 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE1 EESLKLKNWSCSSPVFPGNWDLRLLQVRERPVALEAELALTLKVLEAAAG--PALEDVLD :::: ::. .: : .:: .:::: :::::::::::::::::::::::.: ::: :::: NP_742 EESLLLKDCKCRSRLFPRTWDLRQLQVRERPVALEAELALTLKVLEATADTDPALGDVLD 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE1 QPLHTLHHILSQLQACIQPQPTAGPRPRGRLHHWLHRLQEAPKKESAGCLEASVTFNLFR :::::::::::::.:::::::::::: ::::::::::::::::::: ::::::::::::: NP_742 QPLHTLHHILSQLRACIQPQPTAGPRTRGRLHHWLHRLQEAPKKESPGCLEASVTFNLFR 130 140 150 160 170 180 180 190 200 pF1KE1 LLTRDLKYVADGNLCLRTSTHPEST ::::::. ::.:.::. NP_742 LLTRDLNCVASGDLCV 190 >>XP_005258822 (OMIM: 607402,609532) PREDICTED: interfer (200 aa) initn: 948 init1: 521 opt: 899 Z-score: 1064.2 bits: 203.8 E(85289): 1.5e-52 Smith-Waterman score: 899; 74.1% identity (86.8% similar) in 189 aa overlap (8-191:12-200) 10 20 30 40 50 pF1KE1 MAAAWTVVLVTLVLGLAVAGPVPTSK---PTTTGKGCHIGRFKSLSPQELASFKKA ::: .. :.:.: ::... ..::::..::::::::: .::.: XP_005 MKLDMTGDCMPVLVLMAAVLTVTGAVPVARLRGALPDARGCHIAQFKSLSPQELQAFKRA 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE1 RDALEESLKLKNWSCSSPVFPGNWDLRLLQVRERPVALEAELALTLKVLEAAAG--PALE .::::::: ::. .: : .:: .:::: :::::::::::::::::::::::.: ::: XP_005 KDALEESLLLKDCKCRSRLFPRTWDLRQLQVRERPVALEAELALTLKVLEATADTDPALG 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE1 DVLDQPLHTLHHILSQLQACIQPQPTAGPRPRGRLHHWLHRLQEAPKKESAGCLEASVTF :::::::::::::::::.:::::::::::: ::::::::::::::::::: ::::::::: XP_005 DVLDQPLHTLHHILSQLRACIQPQPTAGPRTRGRLHHWLHRLQEAPKKESPGCLEASVTF 130 140 150 160 170 180 180 190 200 pF1KE1 NLFRLLTRDLKYVADGNLCLRTSTHPEST ::::::::::. ::.:.::. XP_005 NLFRLLTRDLNCVASGDLCV 190 200 >>NP_742150 (OMIM: 607401) interferon lambda-2 [Homo sap (200 aa) initn: 930 init1: 509 opt: 884 Z-score: 1046.5 bits: 200.5 E(85289): 1.5e-51 Smith-Waterman score: 884; 72.3% identity (85.9% similar) in 191 aa overlap (6-191:10-200) 10 20 30 40 50 pF1KE1 MAAAWTVVLVTLVLGLAVAGPVPTSK---PTTTGKGCHIGRFKSLSPQELASFKKA : ::: .. :.:.: ::... ..::::..::::::::: .::.: NP_742 MKLDMTGDCTPVLVLMAAVLTVTGAVPVARLHGALPDARGCHIAQFKSLSPQELQAFKRA 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE1 RDALEESLKLKNWSCSSPVFPGNWDLRLLQVRERPVALEAELALTLKVLEAAAG--PALE .::::::: ::. : : .:: .:::: :::::::.:::::::::::::::.: ::: NP_742 KDALEESLLLKDCRCHSRLFPRTWDLRQLQVRERPMALEAELALTLKVLEATADTDPALV 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE1 DVLDQPLHTLHHILSQLQACIQPQPTAGPRPRGRLHHWLHRLQEAPKKESAGCLEASVTF ::::::::::::::::..:::::::::::: ::::::::.:::::::::: ::::::::: NP_742 DVLDQPLHTLHHILSQFRACIQPQPTAGPRTRGRLHHWLYRLQEAPKKESPGCLEASVTF 130 140 150 160 170 180 180 190 200 pF1KE1 NLFRLLTRDLKYVADGNLCLRTSTHPEST ::::::::::. ::.:.::. NP_742 NLFRLLTRDLNCVASGDLCV 190 200 >>NP_001263183 (OMIM: 615090) interferon lambda-4 precur (179 aa) initn: 177 init1: 98 opt: 138 Z-score: 170.0 bits: 38.2 E(85289): 0.0099 Smith-Waterman score: 165; 29.3% identity (53.9% similar) in 191 aa overlap (8-191:5-179) 10 20 30 40 50 pF1KE1 MAAAWTVVLVTLVLGLAVAGPVPTSKPTTTGKGCHIGRFKSLSPQELASFKKARDALEE- : .... :: : : .. : . : .....:: :. ::. : :: :: NP_001 MRPSVWAAVAAGLWVLCTVIAAAP----RRCLLSHYRSLEPRTLAAAKALRDRYEEE 10 20 30 40 50 60 70 80 90 100 110 pF1KE1 SLKLKNWSCS-----SPVFPGNWDLRLLQVRERPVALEAELA-LTLKVLEAAAGPALEDV .:. . .:: .: :.. :: .: . . .: :. : . : .::: :: NP_001 ALSWGQRNCSFRPRRDPPRPSS-CARLRHVARGIADAQAVLSGLHRSELLPGAGPILE-- 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE1 LDQPLHTLHHILSQLQACIQPQPTAGPRPRGRLHHWLHRLQEAPKKESAGCLEASVTFNL : .. ::.. : : .. .: .. . .: : .:::.::: NP_001 ------LLAAAGRDVAACLE---LARPGSSRKVPGAQKRRHKPRRADSPRCRKASVVFNL 120 130 140 150 160 180 190 200 pF1KE1 FRLLTRDLKYVADGNLCLRTSTHPEST .:::: .:. .: .. :: NP_001 LRLLTWELRLAAHSGPCL 170 200 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 05:02:05 2016 done: Sun Nov 6 05:02:06 2016 Total Scan time: 5.990 Total Display time: -0.010 Function used was FASTA [36.3.4 Apr, 2011]