FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE4386, 406 aa 1>>>pF1KE4386 406 - 406 aa - 406 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.0334+/-0.000343; mu= 8.8477+/- 0.021 mean_var=126.0441+/-25.489, 0's: 0 Z-trim(117.9): 84 B-trim: 30 in 1/54 Lambda= 0.114239 statistics sampled from 30322 (30421) to 30322 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.734), E-opt: 0.2 (0.357), width: 16 Scan time: 8.540 The best scores are: opt bits E(85289) NP_647475 (OMIM: 605910,615881) angiopoietin-relat ( 406) 2806 473.7 3.6e-133 XP_005272541 (OMIM: 605910,615881) PREDICTED: angi ( 424) 2369 401.7 1.8e-111 NP_001034756 (OMIM: 605910,615881) angiopoietin-re ( 368) 1322 229.1 1.4e-59 XP_005272542 (OMIM: 605910,615881) PREDICTED: angi ( 386) 1211 210.8 4.7e-54 NP_055310 (OMIM: 604774,605019) angiopoietin-relat ( 460) 699 126.5 1.4e-28 XP_016868807 (OMIM: 601922) PREDICTED: angiopoieti ( 443) 608 111.5 4.3e-24 NP_001112359 (OMIM: 601922) angiopoietin-2 isoform ( 495) 608 111.5 4.7e-24 NP_001112360 (OMIM: 601922) angiopoietin-2 isoform ( 444) 606 111.1 5.4e-24 NP_001138 (OMIM: 601922) angiopoietin-2 isoform a ( 496) 606 111.2 5.9e-24 XP_005245634 (OMIM: 603874) PREDICTED: angiopoieti ( 491) 591 108.7 3.3e-23 NP_004664 (OMIM: 603874) angiopoietin-related prot ( 491) 591 108.7 3.3e-23 XP_011527541 (OMIM: 603705) PREDICTED: angiopoieti ( 451) 581 107.0 9.5e-23 NP_057069 (OMIM: 603705) angiopoietin-4 isoform 1 ( 503) 581 107.0 1e-22 NP_001300980 (OMIM: 601667) angiopoietin-1 isoform ( 298) 577 106.2 1.1e-22 NP_001186788 (OMIM: 601667) angiopoietin-1 isoform ( 497) 577 106.4 1.6e-22 NP_001137 (OMIM: 601667) angiopoietin-1 isoform 1 ( 498) 577 106.4 1.6e-22 NP_036230 (OMIM: 605001) angiopoietin-related prot ( 493) 561 103.7 1e-21 NP_003656 (OMIM: 604973,613860) ficolin-3 isoform ( 299) 545 101.0 4.2e-21 NP_001138578 (OMIM: 613357) fibrinogen C domain-co ( 461) 548 101.6 4.2e-21 NP_116232 (OMIM: 613357) fibrinogen C domain-conta ( 461) 548 101.6 4.2e-21 XP_011526649 (OMIM: 609336) PREDICTED: angiopoieti ( 470) 548 101.6 4.3e-21 NP_001308340 (OMIM: 609336) angiopoietin-related p ( 470) 548 101.6 4.3e-21 XP_016882836 (OMIM: 609336) PREDICTED: angiopoieti ( 470) 548 101.6 4.3e-21 XP_011526652 (OMIM: 609336) PREDICTED: angiopoieti ( 470) 548 101.6 4.3e-21 NP_114123 (OMIM: 609336) angiopoietin-related prot ( 470) 548 101.6 4.3e-21 XP_011526650 (OMIM: 609336) PREDICTED: angiopoieti ( 537) 548 101.6 4.8e-21 XP_011526651 (OMIM: 609336) PREDICTED: angiopoieti ( 537) 548 101.6 4.8e-21 XP_005260148 (OMIM: 609336) PREDICTED: angiopoieti ( 551) 548 101.6 4.9e-21 NP_001994 (OMIM: 601252) ficolin-1 precursor [Homo ( 326) 539 100.0 8.9e-21 XP_006717078 (OMIM: 601624) PREDICTED: ficolin-2 i ( 264) 533 99.0 1.5e-20 NP_056652 (OMIM: 601624) ficolin-2 isoform b precu ( 275) 533 99.0 1.5e-20 XP_011516694 (OMIM: 601624) PREDICTED: ficolin-2 i ( 302) 533 99.0 1.7e-20 NP_004099 (OMIM: 601624) ficolin-2 isoform a precu ( 313) 533 99.0 1.7e-20 NP_775628 (OMIM: 604973,613860) ficolin-3 isoform ( 288) 522 97.2 5.6e-20 NP_002395 (OMIM: 600596) microfibril-associated gl ( 255) 494 92.5 1.2e-18 NP_001185624 (OMIM: 600596) microfibril-associated ( 279) 494 92.5 1.3e-18 NP_006673 (OMIM: 605351) fibroleukin precursor [Ho ( 439) 469 88.5 3.4e-17 NP_001315564 (OMIM: 601995) tenascin-R isoform 2 [ (1025) 423 81.2 1.3e-14 XP_011508251 (OMIM: 601995) PREDICTED: tenascin-R (1199) 423 81.3 1.4e-14 XP_016857708 (OMIM: 601995) PREDICTED: tenascin-R (1358) 423 81.3 1.6e-14 XP_016857707 (OMIM: 601995) PREDICTED: tenascin-R (1358) 423 81.3 1.6e-14 NP_003276 (OMIM: 601995) tenascin-R isoform 1 prec (1358) 423 81.3 1.6e-14 NP_115859 (OMIM: 600985,606408,615963) tenascin-X ( 673) 402 77.6 1e-13 XP_005252032 (OMIM: 187380,615629) PREDICTED: tena (1564) 397 77.0 3.5e-13 XP_005252031 (OMIM: 187380,615629) PREDICTED: tena (1655) 397 77.1 3.6e-13 XP_006717164 (OMIM: 187380,615629) PREDICTED: tena (1655) 397 77.1 3.6e-13 XP_011516931 (OMIM: 187380,615629) PREDICTED: tena (1746) 397 77.1 3.8e-13 XP_011516930 (OMIM: 187380,615629) PREDICTED: tena (1746) 397 77.1 3.8e-13 XP_005252030 (OMIM: 187380,615629) PREDICTED: tena (1837) 397 77.1 4e-13 XP_011516928 (OMIM: 187380,615629) PREDICTED: tena (1929) 397 77.1 4.1e-13 >>NP_647475 (OMIM: 605910,615881) angiopoietin-related p (406 aa) initn: 2806 init1: 2806 opt: 2806 Z-score: 2511.9 bits: 473.7 E(85289): 3.6e-133 Smith-Waterman score: 2806; 100.0% identity (100.0% similar) in 406 aa overlap (1-406:1-406) 10 20 30 40 50 60 pF1KE4 MSGAPTAGAALMLCAATAVLLSAQGGPVQSKSPRFASWDEMNVLAHGLLQLGQGLREHAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_647 MSGAPTAGAALMLCAATAVLLSAQGGPVQSKSPRFASWDEMNVLAHGLLQLGQGLREHAE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 RTRSQLSALERRLSACGSACQGTEGSTDLPLAPESRVDPEVLHSLQTQLKAQNSRIQQLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_647 RTRSQLSALERRLSACGSACQGTEGSTDLPLAPESRVDPEVLHSLQTQLKAQNSRIQQLF 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 HKVAQQQRHLEKQHLRIQHLQSQFGLLDHKHLDHEVAKPARRKRLPEMAQPVDPAHNVSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_647 HKVAQQQRHLEKQHLRIQHLQSQFGLLDHKHLDHEVAKPARRKRLPEMAQPVDPAHNVSR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 LHRLPRDCQELFQVGERQSGLFEIQPQGSPPFLVNCKMTSDGGWTVIQRRHDGSVDFNRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_647 LHRLPRDCQELFQVGERQSGLFEIQPQGSPPFLVNCKMTSDGGWTVIQRRHDGSVDFNRP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 WEAYKAGFGDPHGEFWLGLEKVHSITGDRNSRLAVQLRDWDGNAELLQFSVHLGGEDTAY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_647 WEAYKAGFGDPHGEFWLGLEKVHSITGDRNSRLAVQLRDWDGNAELLQFSVHLGGEDTAY 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 SLQLTAPVAGQLGATTVPPSGLSVPFSTWDQDHDLRRDKNCAKSLSGGWWFGTCSHSNLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_647 SLQLTAPVAGQLGATTVPPSGLSVPFSTWDQDHDLRRDKNCAKSLSGGWWFGTCSHSNLN 310 320 330 340 350 360 370 380 390 400 pF1KE4 GQYFRSIPQQRQKLKKGIFWKTWRGRYYPLQATTMLIQPMAAEAAS :::::::::::::::::::::::::::::::::::::::::::::: NP_647 GQYFRSIPQQRQKLKKGIFWKTWRGRYYPLQATTMLIQPMAAEAAS 370 380 390 400 >>XP_005272541 (OMIM: 605910,615881) PREDICTED: angiopoi (424 aa) initn: 2369 init1: 2369 opt: 2369 Z-score: 2122.4 bits: 401.7 E(85289): 1.8e-111 Smith-Waterman score: 2760; 95.8% identity (95.8% similar) in 424 aa overlap (1-406:1-424) 10 20 30 40 50 60 pF1KE4 MSGAPTAGAALMLCAATAVLLSAQGGPVQSKSPRFASWDEMNVLAHGLLQLGQGLREHAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MSGAPTAGAALMLCAATAVLLSAQGGPVQSKSPRFASWDEMNVLAHGLLQLGQGLREHAE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 RTRSQLSALERRLSACGSACQGTEGSTDLPLAPESRVDPEVLHSLQTQLKAQNSRIQQLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RTRSQLSALERRLSACGSACQGTEGSTDLPLAPESRVDPEVLHSLQTQLKAQNSRIQQLF 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 HKVAQQQRHLEKQHLRIQHLQSQFGLLDHKHLDHEVAKPARRKRLPEMAQPVDPAHNVSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 HKVAQQQRHLEKQHLRIQHLQSQFGLLDHKHLDHEVAKPARRKRLPEMAQPVDPAHNVSR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 LHRLPRDCQELFQVGERQSGLFEIQPQGSPPFLVNCKMTSDGGWTVIQRRHDGSVDFNRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LHRLPRDCQELFQVGERQSGLFEIQPQGSPPFLVNCKMTSDGGWTVIQRRHDGSVDFNRP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 WEAYKAGFGDPHGEFWLGLEKVHSITGDRNSRLAVQLRDWDGNAELLQFSVHLGGEDTAY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 WEAYKAGFGDPHGEFWLGLEKVHSITGDRNSRLAVQLRDWDGNAELLQFSVHLGGEDTAY 250 260 270 280 290 300 310 320 330 340 pF1KE4 SLQLTAPVAGQLGATTVPPSGLSVPFSTWDQDHDLRRDKNCAKSLS-------------- :::::::::::::::::::::::::::::::::::::::::::::: XP_005 SLQLTAPVAGQLGATTVPPSGLSVPFSTWDQDHDLRRDKNCAKSLSAPSVAQRPDHVPSP 310 320 330 340 350 360 350 360 370 380 390 400 pF1KE4 ----GGWWFGTCSHSNLNGQYFRSIPQQRQKLKKGIFWKTWRGRYYPLQATTMLIQPMAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LTPAGGWWFGTCSHSNLNGQYFRSIPQQRQKLKKGIFWKTWRGRYYPLQATTMLIQPMAA 370 380 390 400 410 420 pF1KE4 EAAS :::: XP_005 EAAS >>NP_001034756 (OMIM: 605910,615881) angiopoietin-relate (368 aa) initn: 2513 init1: 1316 opt: 1322 Z-score: 1190.7 bits: 229.1 E(85289): 1.4e-59 Smith-Waterman score: 2441; 90.4% identity (90.6% similar) in 406 aa overlap (1-406:1-368) 10 20 30 40 50 60 pF1KE4 MSGAPTAGAALMLCAATAVLLSAQGGPVQSKSPRFASWDEMNVLAHGLLQLGQGLREHAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSGAPTAGAALMLCAATAVLLSAQGGPVQSKSPRFASWDEMNVLAHGLLQLGQGLREHAE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 RTRSQLSALERRLSACGSACQGTEGSTDLPLAPESRVDPEVLHSLQTQLKAQNSRIQQLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RTRSQLSALERRLSACGSACQGTEGSTDLPLAPESRVDPEVLHSLQTQLKAQNSRIQQLF 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 HKVAQQQRHLEKQHLRIQHLQSQFGLLDHKHLDHEVAKPARRKRLPEMAQPVDPAHNVSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HKVAQQQRHLEKQHLRIQHLQSQFGLLDHKHLDHEVAKPARRKRLPEMAQPVDPAHNVSR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 LHRLPRDCQELFQVGERQSGLFEIQPQGSPPFLVNCKMTSDGGWTVIQRRHDGSVDFNRP ::. ::::::::::::::::::: NP_001 LHH--------------------------------------GGWTVIQRRHDGSVDFNRP 190 200 250 260 270 280 290 300 pF1KE4 WEAYKAGFGDPHGEFWLGLEKVHSITGDRNSRLAVQLRDWDGNAELLQFSVHLGGEDTAY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 WEAYKAGFGDPHGEFWLGLEKVHSITGDRNSRLAVQLRDWDGNAELLQFSVHLGGEDTAY 210 220 230 240 250 260 310 320 330 340 350 360 pF1KE4 SLQLTAPVAGQLGATTVPPSGLSVPFSTWDQDHDLRRDKNCAKSLSGGWWFGTCSHSNLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SLQLTAPVAGQLGATTVPPSGLSVPFSTWDQDHDLRRDKNCAKSLSGGWWFGTCSHSNLN 270 280 290 300 310 320 370 380 390 400 pF1KE4 GQYFRSIPQQRQKLKKGIFWKTWRGRYYPLQATTMLIQPMAAEAAS :::::::::::::::::::::::::::::::::::::::::::::: NP_001 GQYFRSIPQQRQKLKKGIFWKTWRGRYYPLQATTMLIQPMAAEAAS 330 340 350 360 >>XP_005272542 (OMIM: 605910,615881) PREDICTED: angiopoi (386 aa) initn: 2076 init1: 1211 opt: 1211 Z-score: 1091.5 bits: 210.8 E(85289): 4.7e-54 Smith-Waterman score: 2395; 86.6% identity (86.8% similar) in 424 aa overlap (1-406:1-386) 10 20 30 40 50 60 pF1KE4 MSGAPTAGAALMLCAATAVLLSAQGGPVQSKSPRFASWDEMNVLAHGLLQLGQGLREHAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MSGAPTAGAALMLCAATAVLLSAQGGPVQSKSPRFASWDEMNVLAHGLLQLGQGLREHAE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 RTRSQLSALERRLSACGSACQGTEGSTDLPLAPESRVDPEVLHSLQTQLKAQNSRIQQLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RTRSQLSALERRLSACGSACQGTEGSTDLPLAPESRVDPEVLHSLQTQLKAQNSRIQQLF 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 HKVAQQQRHLEKQHLRIQHLQSQFGLLDHKHLDHEVAKPARRKRLPEMAQPVDPAHNVSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 HKVAQQQRHLEKQHLRIQHLQSQFGLLDHKHLDHEVAKPARRKRLPEMAQPVDPAHNVSR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 LHRLPRDCQELFQVGERQSGLFEIQPQGSPPFLVNCKMTSDGGWTVIQRRHDGSVDFNRP ::. ::::::::::::::::::: XP_005 LHH--------------------------------------GGWTVIQRRHDGSVDFNRP 190 200 250 260 270 280 290 300 pF1KE4 WEAYKAGFGDPHGEFWLGLEKVHSITGDRNSRLAVQLRDWDGNAELLQFSVHLGGEDTAY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 WEAYKAGFGDPHGEFWLGLEKVHSITGDRNSRLAVQLRDWDGNAELLQFSVHLGGEDTAY 210 220 230 240 250 260 310 320 330 340 pF1KE4 SLQLTAPVAGQLGATTVPPSGLSVPFSTWDQDHDLRRDKNCAKSLS-------------- :::::::::::::::::::::::::::::::::::::::::::::: XP_005 SLQLTAPVAGQLGATTVPPSGLSVPFSTWDQDHDLRRDKNCAKSLSAPSVAQRPDHVPSP 270 280 290 300 310 320 350 360 370 380 390 400 pF1KE4 ----GGWWFGTCSHSNLNGQYFRSIPQQRQKLKKGIFWKTWRGRYYPLQATTMLIQPMAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LTPAGGWWFGTCSHSNLNGQYFRSIPQQRQKLKKGIFWKTWRGRYYPLQATTMLIQPMAA 330 340 350 360 370 380 pF1KE4 EAAS :::: XP_005 EAAS >>NP_055310 (OMIM: 604774,605019) angiopoietin-related p (460 aa) initn: 738 init1: 371 opt: 699 Z-score: 634.4 bits: 126.5 E(85289): 1.4e-28 Smith-Waterman score: 699; 35.4% identity (67.2% similar) in 314 aa overlap (93-404:153-458) 70 80 90 100 110 120 pF1KE4 RSQLSALERRLSACGSACQGTEGSTDLPLAPESRVDPEVLHSLQTQLKAQNSRIQQLFHK ::. ::: ::.: .. :.. :..:.. NP_055 KLESLLEEKILLQQKVKYLEEQLTNLIQNQPETPEHPEVT-SLKTFVEKQDNSIKDLLQT 130 140 150 160 170 180 130 140 150 160 170 180 pF1KE4 VAQQQRHLEKQHLRIQHLQSQFGLLD-HKHLDHEVAKPARRKRLPEMAQPVDPAHNVSRL : .: ..:..:: .:.....:. . .. . ... : : . : .. .:: . NP_055 VEDQYKQLNQQHSQIKEIENQLRRTSIQEPTEISLSSKPRAPRTTPFLQ-LNEIRNV-KH 190 200 210 220 230 190 200 210 220 230 240 pF1KE4 HRLPRDCQELFQVGERQSGLFEIQPQGSPPFLVNCKMTSDGGWTVIQRRHDGSVDFNRPW .: .: ... ::. ::.. :.:..: : : : . : . ::.::.: ::: .::. : NP_055 DGIPAECTTIYNRGEHTSGMYAIRPSNSQVFHVYCDVISGSPWTLIQHRIDGSQNFNETW 240 250 260 270 280 290 250 260 270 280 290 300 pF1KE4 EAYKAGFGDPHGEFWLGLEKVHSITGDRNSRLAVQLRDWDGNAELLQFSVHLGGEDTAYS : :: ::: :::::::::..::. . : : ..:.:: : . ...: .::...: :. NP_055 ENYKYGFGRLDGEFWLGLEKIYSIVKQSNYVLRIELEDWKDNKHYIEYSFYLGNHETNYT 300 310 320 330 340 350 310 320 330 340 350 360 pF1KE4 LQLTAPVAGQLGATTVPPSGLSVPFSTWDQDHDLRRDKNCAKSLSGGWWF-GTCSHSNLN :.:.: ..:.. . : . .. ::::: : . :: .. :::::. :...::: NP_055 LHLVA-ITGNVPNAI--PENKDLVFSTWD--HKAKGHFNCPEGYSGGWWWHDECGENNLN 360 370 380 390 400 410 370 380 390 400 pF1KE4 GQYFRSIPQQRQKLKKGIFWKTWRGRYYPLQATTMLIQPMAAEAAS :.: . ... . ..:. ::. :: : ...: :::.: .:. NP_055 GKYNKPRAKSKPERRRGLSWKSQNGRLYSIKSTKMLIHPTDSESFE 420 430 440 450 460 >>XP_016868807 (OMIM: 601922) PREDICTED: angiopoietin-2 (443 aa) initn: 462 init1: 285 opt: 608 Z-score: 553.5 bits: 111.5 E(85289): 4.3e-24 Smith-Waterman score: 608; 33.4% identity (63.5% similar) in 356 aa overlap (60-399:100-440) 30 40 50 60 70 80 pF1KE4 SKSPRFASWDEMNVLAHGLLQLGQGLREHAERTRSQLSALERRLSACGSACQGTEGSTDL . :: .:. ::. ::. : . .... XP_016 PLEYDDSVQRLQVLENIMENNTQWLMKVLNQTTRLELQLLEHSLSTNKLEKQILDQTSEI 70 80 90 100 110 120 90 100 110 120 130 140 pF1KE4 PLAPE--SRVDPEVL-----HSLQTQ-LKAQNSRIQQLFHKVAQQQRHLEKQHLRIQHLQ . : .. .:: : .: : .: .....: : :..:. .:. . .: XP_016 NKLQDKNSFLEKKVLAMEDKHIIQLQSIKEEKDQLQVL---VSKQNSIIEELEKKIVTAT 130 140 150 160 170 180 150 160 170 180 190 200 pF1KE4 SQFGLLDHKHLDHEVAKPARRKRLPEMAQPVDPAHNVSRLHRLP-RDCQELFQVGERQSG . ..:.... :.. . . . : :. . .:.. ... ::: :.:. :. .: XP_016 VNNSVLQKQQ--HDLMETVN-NLLTMMSTSNSKDPTVAKEEQISFRDCAEVFKSGHTTNG 190 200 210 220 230 240 210 220 230 240 250 pF1KE4 LFEIQ-PQGSPPFLVNCKMTSDGG-WTVIQRRHDGSVDFNRPWEAYKAGFGDPHGEFWLG .. . :... . . : : . :: ::.::::.::::::.: :. ::.:::.: ::.::: XP_016 IYTLTFPNSTEEIKAYCDMEAGGGGWTIIQRREDGSVDFQRTWKEYKVGFGNPSGEYWLG 250 260 270 280 290 300 260 270 280 290 300 310 pF1KE4 LEKVHSITGDRNSRLAVQLRDWDGN-AELLQFSVHLGGEDTAYSLQLTA--PVAGQLGAT : : ..:... : ..:.::.:: : : .:..:. : ..: . .::.... XP_016 NEFVSQLTNQQRYVLKIHLKDWEGNEAYSLYEHFYLSSEELNYRIHLKGLTGTAGKISSI 310 320 330 340 350 360 320 330 340 350 360 370 pF1KE4 TVPPSGLSVPFSTWDQDHDLRRDKNCAKSLSGGWWFGTCSHSNLNGQYFRSIPQQRQKLK . : . ::: : :.: . .:.. :.::::: .:. :::::.:. :: ::. . XP_016 SQPGN----DFSTKDGDND-KCICKCSQMLTGGWWFDACGPSNLNGMYY---PQ-RQNTN 370 380 390 400 410 380 390 400 pF1KE4 K--GIFWKTWRGRYYPLQATTMLIQPMAAEAAS : :: : :.: : :.::::.:.: XP_016 KFNGIKWYYWKGSGYSLKATTMMIRPADF 420 430 440 >>NP_001112359 (OMIM: 601922) angiopoietin-2 isoform b p (495 aa) initn: 462 init1: 285 opt: 608 Z-score: 552.8 bits: 111.5 E(85289): 4.7e-24 Smith-Waterman score: 608; 33.4% identity (63.5% similar) in 356 aa overlap (60-399:152-492) 30 40 50 60 70 80 pF1KE4 SKSPRFASWDEMNVLAHGLLQLGQGLREHAERTRSQLSALERRLSACGSACQGTEGSTDL . :: .:. ::. ::. : . .... NP_001 AVMIEIGTNLLNQTAEQTRKLTDVEAQVLNQTTRLELQLLEHSLSTNKLEKQILDQTSEI 130 140 150 160 170 180 90 100 110 120 130 140 pF1KE4 PLAPE--SRVDPEVL-----HSLQTQ-LKAQNSRIQQLFHKVAQQQRHLEKQHLRIQHLQ . : .. .:: : .: : .: .....: : :..:. .:. . .: NP_001 NKLQDKNSFLEKKVLAMEDKHIIQLQSIKEEKDQLQVL---VSKQNSIIEELEKKIVTAT 190 200 210 220 230 150 160 170 180 190 200 pF1KE4 SQFGLLDHKHLDHEVAKPARRKRLPEMAQPVDPAHNVSRLHRLP-RDCQELFQVGERQSG . ..:.... :.. . . . : :. . .:.. ... ::: :.:. :. .: NP_001 VNNSVLQKQQ--HDLMETVN-NLLTMMSTSNSKDPTVAKEEQISFRDCAEVFKSGHTTNG 240 250 260 270 280 290 210 220 230 240 250 pF1KE4 LFEIQ-PQGSPPFLVNCKMTSDGG-WTVIQRRHDGSVDFNRPWEAYKAGFGDPHGEFWLG .. . :... . . : : . :: ::.::::.::::::.: :. ::.:::.: ::.::: NP_001 IYTLTFPNSTEEIKAYCDMEAGGGGWTIIQRREDGSVDFQRTWKEYKVGFGNPSGEYWLG 300 310 320 330 340 350 260 270 280 290 300 310 pF1KE4 LEKVHSITGDRNSRLAVQLRDWDGN-AELLQFSVHLGGEDTAYSLQLTA--PVAGQLGAT : : ..:... : ..:.::.:: : : .:..:. : ..: . .::.... NP_001 NEFVSQLTNQQRYVLKIHLKDWEGNEAYSLYEHFYLSSEELNYRIHLKGLTGTAGKISSI 360 370 380 390 400 410 320 330 340 350 360 370 pF1KE4 TVPPSGLSVPFSTWDQDHDLRRDKNCAKSLSGGWWFGTCSHSNLNGQYFRSIPQQRQKLK . : . ::: : :.: . .:.. :.::::: .:. :::::.:. :: ::. . NP_001 SQPGN----DFSTKDGDND-KCICKCSQMLTGGWWFDACGPSNLNGMYY---PQ-RQNTN 420 430 440 450 460 380 390 400 pF1KE4 K--GIFWKTWRGRYYPLQATTMLIQPMAAEAAS : :: : :.: : :.::::.:.: NP_001 KFNGIKWYYWKGSGYSLKATTMMIRPADF 470 480 490 >>NP_001112360 (OMIM: 601922) angiopoietin-2 isoform c p (444 aa) initn: 462 init1: 285 opt: 606 Z-score: 551.7 bits: 111.1 E(85289): 5.4e-24 Smith-Waterman score: 606; 33.5% identity (63.7% similar) in 358 aa overlap (60-399:100-441) 30 40 50 60 70 80 pF1KE4 SKSPRFASWDEMNVLAHGLLQLGQGLREHAERTRSQLSALERRLSACGSACQGTEGSTDL . :: .:. ::. ::. : . .... NP_001 PLEYDDSVQRLQVLENIMENNTQWLMKVLNQTTRLELQLLEHSLSTNKLEKQILDQTSEI 70 80 90 100 110 120 90 100 110 120 130 140 pF1KE4 PLAPE--SRVDPEVL-----HSLQTQ-LKAQNSRIQQLFHKVAQQQRHLEKQHLRIQHLQ . : .. .:: : .: : .: .....: : :..:. .:. . .: NP_001 NKLQDKNSFLEKKVLAMEDKHIIQLQSIKEEKDQLQVL---VSKQNSIIEELEKKIVTAT 130 140 150 160 170 180 150 160 170 180 190 pF1KE4 SQFGLLDHKHLDHEVAKPARRKRLPEMAQPVDPAHN--VSRLHRLP-RDCQELFQVGERQ . ..:.... :.. . . . : : . . :.. :.. ... ::: :.:. :. NP_001 VNNSVLQKQQ--HDLMETV--NNLLTMMSTSNSAKDPTVAKEEQISFRDCAEVFKSGHTT 190 200 210 220 230 240 200 210 220 230 240 250 pF1KE4 SGLFEIQ-PQGSPPFLVNCKMTSDGG-WTVIQRRHDGSVDFNRPWEAYKAGFGDPHGEFW .:.. . :... . . : : . :: ::.::::.::::::.: :. ::.:::.: ::.: NP_001 NGIYTLTFPNSTEEIKAYCDMEAGGGGWTIIQRREDGSVDFQRTWKEYKVGFGNPSGEYW 250 260 270 280 290 300 260 270 280 290 300 310 pF1KE4 LGLEKVHSITGDRNSRLAVQLRDWDGN-AELLQFSVHLGGEDTAYSLQLTA--PVAGQLG :: : : ..:... : ..:.::.:: : : .:..:. : ..: . .::... NP_001 LGNEFVSQLTNQQRYVLKIHLKDWEGNEAYSLYEHFYLSSEELNYRIHLKGLTGTAGKIS 310 320 330 340 350 360 320 330 340 350 360 370 pF1KE4 ATTVPPSGLSVPFSTWDQDHDLRRDKNCAKSLSGGWWFGTCSHSNLNGQYFRSIPQQRQK . . : . ::: : :.: . .:.. :.::::: .:. :::::.:. :: ::. NP_001 SISQPGN----DFSTKDGDND-KCICKCSQMLTGGWWFDACGPSNLNGMYY---PQ-RQN 370 380 390 400 410 380 390 400 pF1KE4 LKK--GIFWKTWRGRYYPLQATTMLIQPMAAEAAS .: :: : :.: : :.::::.:.: NP_001 TNKFNGIKWYYWKGSGYSLKATTMMIRPADF 420 430 440 >>NP_001138 (OMIM: 601922) angiopoietin-2 isoform a prec (496 aa) initn: 462 init1: 285 opt: 606 Z-score: 551.0 bits: 111.2 E(85289): 5.9e-24 Smith-Waterman score: 606; 33.5% identity (63.7% similar) in 358 aa overlap (60-399:152-493) 30 40 50 60 70 80 pF1KE4 SKSPRFASWDEMNVLAHGLLQLGQGLREHAERTRSQLSALERRLSACGSACQGTEGSTDL . :: .:. ::. ::. : . .... NP_001 AVMIEIGTNLLNQTAEQTRKLTDVEAQVLNQTTRLELQLLEHSLSTNKLEKQILDQTSEI 130 140 150 160 170 180 90 100 110 120 130 140 pF1KE4 PLAPE--SRVDPEVL-----HSLQTQ-LKAQNSRIQQLFHKVAQQQRHLEKQHLRIQHLQ . : .. .:: : .: : .: .....: : :..:. .:. . .: NP_001 NKLQDKNSFLEKKVLAMEDKHIIQLQSIKEEKDQLQVL---VSKQNSIIEELEKKIVTAT 190 200 210 220 230 150 160 170 180 190 pF1KE4 SQFGLLDHKHLDHEVAKPARRKRLPEMAQPVDPAHN--VSRLHRLP-RDCQELFQVGERQ . ..:.... :.. . . . : : . . :.. :.. ... ::: :.:. :. NP_001 VNNSVLQKQQ--HDLMETV--NNLLTMMSTSNSAKDPTVAKEEQISFRDCAEVFKSGHTT 240 250 260 270 280 290 200 210 220 230 240 250 pF1KE4 SGLFEIQ-PQGSPPFLVNCKMTSDGG-WTVIQRRHDGSVDFNRPWEAYKAGFGDPHGEFW .:.. . :... . . : : . :: ::.::::.::::::.: :. ::.:::.: ::.: NP_001 NGIYTLTFPNSTEEIKAYCDMEAGGGGWTIIQRREDGSVDFQRTWKEYKVGFGNPSGEYW 300 310 320 330 340 350 260 270 280 290 300 310 pF1KE4 LGLEKVHSITGDRNSRLAVQLRDWDGN-AELLQFSVHLGGEDTAYSLQLTA--PVAGQLG :: : : ..:... : ..:.::.:: : : .:..:. : ..: . .::... NP_001 LGNEFVSQLTNQQRYVLKIHLKDWEGNEAYSLYEHFYLSSEELNYRIHLKGLTGTAGKIS 360 370 380 390 400 410 320 330 340 350 360 370 pF1KE4 ATTVPPSGLSVPFSTWDQDHDLRRDKNCAKSLSGGWWFGTCSHSNLNGQYFRSIPQQRQK . . : . ::: : :.: . .:.. :.::::: .:. :::::.:. :: ::. NP_001 SISQPGN----DFSTKDGDND-KCICKCSQMLTGGWWFDACGPSNLNGMYY---PQ-RQN 420 430 440 450 460 380 390 400 pF1KE4 LKK--GIFWKTWRGRYYPLQATTMLIQPMAAEAAS .: :: : :.: : :.::::.:.: NP_001 TNKFNGIKWYYWKGSGYSLKATTMMIRPADF 470 480 490 >>XP_005245634 (OMIM: 603874) PREDICTED: angiopoietin-re (491 aa) initn: 514 init1: 261 opt: 591 Z-score: 537.8 bits: 108.7 E(85289): 3.3e-23 Smith-Waterman score: 595; 34.3% identity (65.7% similar) in 300 aa overlap (117-400:198-490) 90 100 110 120 130 140 pF1KE4 TDLPLAPESRVDPEVLHSLQTQLKAQNSRIQQLFHKVAQQQRHLEKQHLRI--QHLQS-- .: .. ..:. :. ... ::. . XP_005 MATRYRELEVKYASLTDLVNNQSVMITLLEEQCLRIFSRQDTHVSPPLVQVVPQHIPNSQ 170 180 190 200 210 220 150 160 170 180 190 pF1KE4 QF--GLLDHKHLDHEVAKPARRKRLPEMAQPVDPAHN------VSRLHRLP-RDCQELFQ :. ::: ...... . : : .: ..:... :. ... : .:::. . XP_005 QYTPGLLGGNEIQRDPGYP--RDLMPPPDLATSPTKSPFKIPPVTFINEGPFKDCQQAKE 230 240 250 260 270 280 200 210 220 230 240 250 pF1KE4 VGERQSGLFEIQPQGSP-PFLVNCKMTSD-GGWTVIQRRHDGSVDFNRPWEAYKAGFGDP .:. ::.. :.:..: :. . :. . : :::::::.: ::::.: : :: :: :::. XP_005 AGHSVSGIYMIKPENSNGPMQLWCENSLDPGGWTVIQKRTDGSVNFFRNWENYKKGFGNI 290 300 310 320 330 340 260 270 280 290 300 310 pF1KE4 HGEFWLGLEKVHSITGDRNSRLAVQLRDWDGNAELLQFS-VHLGGEDTAYSLQLTAPVAG ::.:::::... .... : .: ..:.::. . ..: .: :. : :.: . : XP_005 DGEYWLGLENIYMLSNQDNYKLLIELEDWSDKKVYAEYSSFRLEPESEFYRLRL-GTYQG 350 360 370 380 390 400 320 330 340 350 360 370 pF1KE4 QLGATTVPPSGLSVPFSTWDQDHDLRRDKNCAKSLSGGWWFGTCSHSNLNGQYFRSIPQQ . : . . .: . :.: :.:.:. :::. .::::...:.:::::: ..:. . XP_005 NAGDSMMWHNGKQ--FTTLDRDKDMYAG-NCAHFHKGGWWYNACAHSNLNGVWYRG-GHY 410 420 430 440 450 460 380 390 400 pF1KE4 RQKLKKGIFWKTWRGRYYPLQATTMLIQPMAAEAAS :.: . :::: .:: : :.:. :.:.:. XP_005 RSKHQDGIFWAEYRGGSYSLRAVQMMIKPID 470 480 490 406 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 22:58:04 2016 done: Sat Nov 5 22:58:05 2016 Total Scan time: 8.540 Total Display time: 0.020 Function used was FASTA [36.3.4 Apr, 2011]