FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE6686, 282 aa 1>>>pF1KE6686 282 - 282 aa - 282 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.5290+/-0.000274; mu= 12.0916+/- 0.017 mean_var=145.6272+/-28.356, 0's: 0 Z-trim(124.0): 98 B-trim: 216 in 1/61 Lambda= 0.106280 statistics sampled from 44581 (44703) to 44581 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.819), E-opt: 0.2 (0.524), width: 16 Scan time: 7.360 The best scores are: opt bits E(85289) NP_057663 (OMIM: 606475,613646) CD320 antigen isof ( 282) 1952 309.8 3.6e-84 NP_001159367 (OMIM: 606475,613646) CD320 antigen i ( 240) 1315 212.1 8.2e-55 NP_059992 (OMIM: 602600,608446) low-density lipopr ( 700) 399 72.1 3.3e-12 XP_005271232 (OMIM: 602600,608446) PREDICTED: low- ( 834) 399 72.2 3.7e-12 XP_005271231 (OMIM: 602600,608446) PREDICTED: low- ( 847) 399 72.2 3.7e-12 NP_001309155 (OMIM: 192977,224050) very low-densit ( 804) 347 64.2 9.1e-10 NP_001309154 (OMIM: 192977,224050) very low-densit ( 832) 347 64.2 9.3e-10 NP_002323 (OMIM: 107770) prolow-density lipoprotei (4544) 330 62.4 1.8e-08 XP_016874792 (OMIM: 107770) PREDICTED: prolow-dens (4561) 330 62.4 1.8e-08 XP_016859831 (OMIM: 608766) PREDICTED: low-density (2883) 321 60.8 3.5e-08 XP_016859830 (OMIM: 608766) PREDICTED: low-density (4469) 321 61.0 4.7e-08 NP_061027 (OMIM: 608766) low-density lipoprotein r (4599) 321 61.0 4.8e-08 NP_001018066 (OMIM: 192977,224050) very low-densit ( 845) 308 58.3 5.9e-08 NP_003374 (OMIM: 192977,224050) very low-density l ( 873) 308 58.3 6.1e-08 XP_011509486 (OMIM: 222448,600073) PREDICTED: low- (3892) 314 59.8 9e-08 XP_011540398 (OMIM: 602600,608446) PREDICTED: low- ( 762) 303 57.4 9.4e-08 XP_016857755 (OMIM: 602600,608446) PREDICTED: low- ( 842) 303 57.5 1e-07 XP_011509485 (OMIM: 222448,600073) PREDICTED: low- (4612) 314 59.9 1e-07 NP_004516 (OMIM: 222448,600073) low-density lipopr (4655) 314 59.9 1e-07 XP_006710945 (OMIM: 602600,608446) PREDICTED: low- ( 901) 303 57.5 1.1e-07 NP_001018064 (OMIM: 602600,608446) low-density lip ( 904) 303 57.5 1.1e-07 XP_006710944 (OMIM: 602600,608446) PREDICTED: low- ( 917) 303 57.5 1.1e-07 XP_016857754 (OMIM: 602600,608446) PREDICTED: low- ( 921) 303 57.5 1.1e-07 XP_011540396 (OMIM: 602600,608446) PREDICTED: low- ( 934) 303 57.5 1.1e-07 NP_004622 (OMIM: 602600,608446) low-density lipopr ( 963) 303 57.5 1.1e-07 XP_005271230 (OMIM: 602600,608446) PREDICTED: low- ( 976) 303 57.5 1.1e-07 XP_011526312 (OMIM: 143890,606945) PREDICTED: low- ( 834) 298 56.7 1.7e-07 NP_001182727 (OMIM: 143890,606945) low-density lip ( 858) 298 56.7 1.7e-07 NP_000518 (OMIM: 143890,606945) low-density lipopr ( 860) 298 56.7 1.7e-07 XP_011541269 (OMIM: 104300,602005) PREDICTED: sort (1158) 296 56.6 2.6e-07 XP_016873661 (OMIM: 104300,602005) PREDICTED: sort (1334) 296 56.6 2.9e-07 XP_011541267 (OMIM: 104300,602005) PREDICTED: sort (1701) 296 56.7 3.4e-07 XP_016873660 (OMIM: 104300,602005) PREDICTED: sort (1769) 296 56.7 3.5e-07 XP_016873659 (OMIM: 104300,602005) PREDICTED: sort (2039) 296 56.8 3.9e-07 XP_016873658 (OMIM: 104300,602005) PREDICTED: sort (2110) 296 56.8 4e-07 XP_011541265 (OMIM: 104300,602005) PREDICTED: sort (2176) 296 56.8 4.1e-07 NP_003096 (OMIM: 104300,602005) sortilin-related r (2214) 296 56.8 4.1e-07 NP_001316155 (OMIM: 609921) low-density lipoprotei ( 556) 264 51.3 4.8e-06 NP_054764 (OMIM: 609921) low-density lipoprotein r ( 713) 264 51.4 5.7e-06 XP_005267567 (OMIM: 609921) PREDICTED: low-density ( 721) 264 51.4 5.7e-06 NP_002324 (OMIM: 603159) low-density lipoprotein r ( 770) 249 49.2 2.9e-05 XP_005259002 (OMIM: 603159) PREDICTED: low-density ( 785) 249 49.2 3e-05 XP_016873223 (OMIM: 212780,604270,614305,616304) P (1809) 251 49.8 4.3e-05 NP_002325 (OMIM: 212780,604270,614305,616304) low- (1905) 251 49.9 4.4e-05 NP_068813 (OMIM: 606797) suppressor of tumorigenic ( 855) 239 47.7 9.1e-05 NP_001182729 (OMIM: 143890,606945) low-density lip ( 692) 228 45.9 0.00025 NP_001182732 (OMIM: 143890,606945) low-density lip ( 682) 221 44.8 0.00053 NP_001182728 (OMIM: 143890,606945) low-density lip ( 819) 205 42.4 0.0033 NP_001265515 (OMIM: 605236,614595) atrial natriure ( 734) 198 41.3 0.0064 NP_006578 (OMIM: 605236,614595) atrial natriuretic (1042) 199 41.6 0.0074 >>NP_057663 (OMIM: 606475,613646) CD320 antigen isoform (282 aa) initn: 1952 init1: 1952 opt: 1952 Z-score: 1632.0 bits: 309.8 E(85289): 3.6e-84 Smith-Waterman score: 1952; 100.0% identity (100.0% similar) in 282 aa overlap (1-282:1-282) 10 20 30 40 50 60 pF1KE6 MSGGWMAQVGAWRTGALGLALLLLLGLGLGLEAAASPLSTPTSAQAAGPSSGSCPPTKFQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 MSGGWMAQVGAWRTGALGLALLLLLGLGLGLEAAASPLSTPTSAQAAGPSSGSCPPTKFQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 CRTSGLCVPLTWRCDRDLDCSDGSDEEECRIEPCTQKGQCPPPPGLPCPCTGVSDCSGGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 CRTSGLCVPLTWRCDRDLDCSDGSDEEECRIEPCTQKGQCPPPPGLPCPCTGVSDCSGGT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 DKKLRNCSRLACLAGELRCTLSDDCIPLTWRCDGHPDCPDSSDELGCGTNEILPEGDATT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 DKKLRNCSRLACLAGELRCTLSDDCIPLTWRCDGHPDCPDSSDELGCGTNEILPEGDATT 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 MGPPVTLESVTSLRNATTMGPPVTLESVPSVGNATSSSAGDQSGSPTAYGVIAAAAVLSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 MGPPVTLESVTSLRNATTMGPPVTLESVPSVGNATSSSAGDQSGSPTAYGVIAAAAVLSA 190 200 210 220 230 240 250 260 270 280 pF1KE6 SLVTATLLLLSWLRAQERLRPLGLLVAMKESLLLSEQKTSLP :::::::::::::::::::::::::::::::::::::::::: NP_057 SLVTATLLLLSWLRAQERLRPLGLLVAMKESLLLSEQKTSLP 250 260 270 280 >>NP_001159367 (OMIM: 606475,613646) CD320 antigen isofo (240 aa) initn: 1609 init1: 1315 opt: 1315 Z-score: 1105.1 bits: 212.1 E(85289): 8.2e-55 Smith-Waterman score: 1529; 85.1% identity (85.1% similar) in 282 aa overlap (1-282:1-240) 10 20 30 40 50 60 pF1KE6 MSGGWMAQVGAWRTGALGLALLLLLGLGLGLEAAASPLSTPTSAQAAGPSSGSCPPTKFQ :::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSGGWMAQVGAWRTGALGLALLLLLGLGLGLEAAASPLSTPTSAQAAG------------ 10 20 30 40 70 80 90 100 110 120 pF1KE6 CRTSGLCVPLTWRCDRDLDCSDGSDEEECRIEPCTQKGQCPPPPGLPCPCTGVSDCSGGT :::::::::::::::::::::::::::::: NP_001 ------------------------------IEPCTQKGQCPPPPGLPCPCTGVSDCSGGT 50 60 70 130 140 150 160 170 180 pF1KE6 DKKLRNCSRLACLAGELRCTLSDDCIPLTWRCDGHPDCPDSSDELGCGTNEILPEGDATT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DKKLRNCSRLACLAGELRCTLSDDCIPLTWRCDGHPDCPDSSDELGCGTNEILPEGDATT 80 90 100 110 120 130 190 200 210 220 230 240 pF1KE6 MGPPVTLESVTSLRNATTMGPPVTLESVPSVGNATSSSAGDQSGSPTAYGVIAAAAVLSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MGPPVTLESVTSLRNATTMGPPVTLESVPSVGNATSSSAGDQSGSPTAYGVIAAAAVLSA 140 150 160 170 180 190 250 260 270 280 pF1KE6 SLVTATLLLLSWLRAQERLRPLGLLVAMKESLLLSEQKTSLP :::::::::::::::::::::::::::::::::::::::::: NP_001 SLVTATLLLLSWLRAQERLRPLGLLVAMKESLLLSEQKTSLP 200 210 220 230 240 >>NP_059992 (OMIM: 602600,608446) low-density lipoprotei (700 aa) initn: 398 init1: 143 opt: 399 Z-score: 340.2 bits: 72.1 E(85289): 3.3e-12 Smith-Waterman score: 399; 37.7% identity (57.9% similar) in 183 aa overlap (6-182:3-178) 10 20 30 40 50 pF1KE6 MSGGWMAQVGAWRTGALGLALLLLLGLGLG--LEAAASPLSTPTSAQAAGPSSGSCPPTK . . : : :: : ::::: : : :::.:: ..: ::.. .: . NP_059 MGLPEPGPLRLLALLLLLLLLLLLQLQHLAAAAADPL---LGGQ--GPAK-DCEKDQ 10 20 30 40 50 60 70 80 90 100 110 pF1KE6 FQCRTSGLCVPLTWRCDRDLDCSDGSDEEECRIEPCTQKG-QCPPPPGLPC--PCTGVSD ::::. :.: .::::.: :: : :::..: . :... : . : : . NP_059 FQCRNER-CIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEE 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE6 CSGGTDKKLRNCSRLACLAGELRC-TLSDDCIPLTWRCDGHPDCPDSSDELGCGTNEILP : :.:.. .:.. .: : .: : : :.: .:::::. :: ..:: ::.:. NP_059 CPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATSLGTC 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE6 EGDATTMGPPVTLESVTSLRNATTMGPPVTLESVPSVGNATSSSAGDQSGSPTAYGVIAA .:: : NP_059 RGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNECLHNNGGCSHICTDLKIGFE 180 190 200 210 220 230 >>XP_005271232 (OMIM: 602600,608446) PREDICTED: low-dens (834 aa) initn: 398 init1: 143 opt: 399 Z-score: 339.3 bits: 72.2 E(85289): 3.7e-12 Smith-Waterman score: 399; 37.7% identity (57.9% similar) in 183 aa overlap (6-182:3-178) 10 20 30 40 50 pF1KE6 MSGGWMAQVGAWRTGALGLALLLLLGLGLG--LEAAASPLSTPTSAQAAGPSSGSCPPTK . . : : :: : ::::: : : :::.:: ..: ::.. .: . XP_005 MGLPEPGPLRLLALLLLLLLLLLLQLQHLAAAAADPL---LGGQ--GPAK-DCEKDQ 10 20 30 40 50 60 70 80 90 100 110 pF1KE6 FQCRTSGLCVPLTWRCDRDLDCSDGSDEEECRIEPCTQKG-QCPPPPGLPC--PCTGVSD ::::. :.: .::::.: :: : :::..: . :... : . : : . XP_005 FQCRNER-CIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEE 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE6 CSGGTDKKLRNCSRLACLAGELRC-TLSDDCIPLTWRCDGHPDCPDSSDELGCGTNEILP : :.:.. .:.. .: : .: : : :.: .:::::. :: ..:: ::.:. XP_005 CPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATSLGTC 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE6 EGDATTMGPPVTLESVTSLRNATTMGPPVTLESVPSVGNATSSSAGDQSGSPTAYGVIAA .:: : XP_005 RGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNECLHNNGGCSHICTDLKIGFE 180 190 200 210 220 230 >>XP_005271231 (OMIM: 602600,608446) PREDICTED: low-dens (847 aa) initn: 398 init1: 143 opt: 399 Z-score: 339.2 bits: 72.2 E(85289): 3.7e-12 Smith-Waterman score: 399; 37.7% identity (57.9% similar) in 183 aa overlap (6-182:3-178) 10 20 30 40 50 pF1KE6 MSGGWMAQVGAWRTGALGLALLLLLGLGLG--LEAAASPLSTPTSAQAAGPSSGSCPPTK . . : : :: : ::::: : : :::.:: ..: ::.. .: . XP_005 MGLPEPGPLRLLALLLLLLLLLLLQLQHLAAAAADPL---LGGQ--GPAK-DCEKDQ 10 20 30 40 50 60 70 80 90 100 110 pF1KE6 FQCRTSGLCVPLTWRCDRDLDCSDGSDEEECRIEPCTQKG-QCPPPPGLPC--PCTGVSD ::::. :.: .::::.: :: : :::..: . :... : . : : . XP_005 FQCRNER-CIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEE 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE6 CSGGTDKKLRNCSRLACLAGELRC-TLSDDCIPLTWRCDGHPDCPDSSDELGCGTNEILP : :.:.. .:.. .: : .: : : :.: .:::::. :: ..:: ::.:. XP_005 CPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATSLGTC 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE6 EGDATTMGPPVTLESVTSLRNATTMGPPVTLESVPSVGNATSSSAGDQSGSPTAYGVIAA .:: : XP_005 RGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQVPPTFLGNRRRPRGLNECLHNNGG 180 190 200 210 220 230 >>NP_001309155 (OMIM: 192977,224050) very low-density li (804 aa) initn: 430 init1: 133 opt: 347 Z-score: 296.4 bits: 64.2 E(85289): 9.1e-10 Smith-Waterman score: 348; 40.7% identity (61.9% similar) in 118 aa overlap (56-167:35-147) 30 40 50 60 70 80 pF1KE6 GLGLGLEAAASPLSTPTSAQAAGPSSGSCPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSD :..::: :.: :. : :.:: : :: :::: NP_001 ALWALWLLLALCWAPRESGATGTGRKAKCEPSQFQC-TNGRCITLLWKCDGDEDCVDGSD 10 20 30 40 50 60 90 100 110 120 130 pF1KE6 EEECRIEPCTQK------GQCPPPPGLPCPCTGVSDCSGGTDKKLRNCSRLACLAGELRC :..: . :... ::: : : : :: :.:.. ..: ..: :. : NP_001 EKNCVKKTCAESDFVCNNGQCVPSRW---KCDGDPDCEDGSDESPEQCRNITCSPDEFTC 70 80 90 100 110 120 140 150 160 170 180 190 pF1KE6 TLSDDCIPLTWRCDGHPDCPDSSDELGCGTNEILPEGDATTMGPPVTLESVTSLRNATTM . : :: .. :.:. :: :.:::: : NP_001 S-SGRCISRNFVCNGQDDCSDGSDELDCAPPTCGAHEFQCSTSSCIPISWVCDDDADCSD 130 140 150 160 170 >>NP_001309154 (OMIM: 192977,224050) very low-density li (832 aa) initn: 430 init1: 133 opt: 347 Z-score: 296.2 bits: 64.2 E(85289): 9.3e-10 Smith-Waterman score: 348; 40.7% identity (61.9% similar) in 118 aa overlap (56-167:35-147) 30 40 50 60 70 80 pF1KE6 GLGLGLEAAASPLSTPTSAQAAGPSSGSCPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSD :..::: :.: :. : :.:: : :: :::: NP_001 ALWALWLLLALCWAPRESGATGTGRKAKCEPSQFQC-TNGRCITLLWKCDGDEDCVDGSD 10 20 30 40 50 60 90 100 110 120 130 pF1KE6 EEECRIEPCTQK------GQCPPPPGLPCPCTGVSDCSGGTDKKLRNCSRLACLAGELRC :..: . :... ::: : : : :: :.:.. ..: ..: :. : NP_001 EKNCVKKTCAESDFVCNNGQCVPSRW---KCDGDPDCEDGSDESPEQCRNITCSPDEFTC 70 80 90 100 110 120 140 150 160 170 180 190 pF1KE6 TLSDDCIPLTWRCDGHPDCPDSSDELGCGTNEILPEGDATTMGPPVTLESVTSLRNATTM . : :: .. :.:. :: :.:::: : NP_001 S-SGRCISRNFVCNGQDDCSDGSDELDCAPPTCGAHEFQCSTSSCIPISWVCDDDADCSD 130 140 150 160 170 >>NP_002323 (OMIM: 107770) prolow-density lipoprotein re (4544 aa) initn: 363 init1: 202 opt: 330 Z-score: 272.9 bits: 62.4 E(85289): 1.8e-08 Smith-Waterman score: 344; 40.5% identity (58.7% similar) in 121 aa overlap (55-167:978-1097) 30 40 50 60 70 80 pF1KE6 LGLGLGLEAAASPLSTPTSAQAAGPSSGSCPPTKFQCRTSGLCVPLTWRCDRDLDCSDGS : :.: : ..: :. ..:::: : ::.:.: NP_002 CIPISWTCDLDDDCGDRSDESASCAYPTCFPLTQFTC-NNGRCININWRCDNDNDCGDNS 950 960 970 980 990 1000 90 100 110 120 130 pF1KE6 DEEECRIEPCTQKGQCPPPPGLPC--PCTGVSDCSGGTDKKLRNCSRLA------CLAGE :: : . . .: .: : : .::. .:. ::. : : . : NP_002 DEAGCSHSCSSTQFKCNSGRCIPEHWTCDGDNDCGDYSDETHANCTNQATRPPGGCHTDE 1010 1020 1030 1040 1050 1060 140 150 160 170 180 190 pF1KE6 LRCTLSDDCIPLTWRCDGHPDCPDSSDELGCGTNEILPEGDATTMGPPVTLESVTSLRNA ..: :. :::: ::::: :: ::::: .: NP_002 FQCRLDGLCIPLRWRCDGDTDCMDSSDEKSCEGVTHVCDPSVKFGCKDSARCISKAWVCD 1070 1080 1090 1100 1110 1120 200 210 220 230 240 250 pF1KE6 TTMGPPVTLESVPSVGNATSSSAGDQSGSPTAYGVIAAAAVLSASLVTATLLLLSWLRAQ NP_002 GDNDCEDNSDEENCESLACRPPSHPCANNTSVCLPPDKLCDGNDDCGDGSDEGELCDQCS 1130 1140 1150 1160 1170 1180 >-- initn: 439 init1: 175 opt: 322 Z-score: 266.3 bits: 61.1 E(85289): 4.3e-08 Smith-Waterman score: 360; 41.5% identity (61.8% similar) in 123 aa overlap (53-169:3535-3649) 30 40 50 60 70 80 pF1KE6 LLLGLGLGLEAAASPLSTPTSAQAAGPSSGSCPPTKFQCRTSGLCVPLTWRCDRDLDCSD .: : .:.:... ::: :.:: : ::.: NP_002 GRCIPARWKCDGEDDCGDGSDEPKEECDERTCEPYQFRCKNNR-CVPGRWQCDYDNDCGD 3510 3520 3530 3540 3550 3560 90 100 110 120 130 pF1KE6 GSDEEECRIEPCTQK------GQCPPPPGLPCPCTGVSDCSGGTDKKLRNCSRLACLAGE .:::: : .::... :.: : : ::. :.:.: .:. : . NP_002 NSDEESCTPRPCSESEFSCANGRCIAGRW---KCDGDHDCADGSDEK--DCTP-RCDMDQ 3570 3580 3590 3600 3610 140 150 160 170 180 190 pF1KE6 LRCTLSDDCIPLTWRCDGHPDCPDSSDELGCGTNEILPEGDATTMGPPVTLESVTSLRNA ..: : :::: ::::. :: :.::: .::: NP_002 FQCK-SGHCIPLRWRCDADADCMDGSDEEACGTGVRTCPLDEFQCNNTLCKPLAWKCDGE 3620 3630 3640 3650 3660 3670 200 210 220 230 240 250 pF1KE6 TTMGPPVTLESVPSVGNATSSSAGDQSGSPTAYGVIAAAAVLSASLVTATLLLLSWLRAQ NP_002 DDCGDNSDENPEECARFVCPPNRPFRCKNDRVCLWIGRQCDGTDNCGDGTDEEDCEPPTA 3680 3690 3700 3710 3720 3730 >-- initn: 332 init1: 175 opt: 322 Z-score: 266.3 bits: 61.1 E(85289): 4.3e-08 Smith-Waterman score: 323; 37.4% identity (63.4% similar) in 131 aa overlap (54-171:3374-3498) 30 40 50 60 70 80 pF1KE6 LLGLGLGLEAAASPLSTPTSAQAAGPSSGSCPPTKFQCRTSGLCVPLTWRCDRDLDCSDG : : .::: : :.:. .. :: : ::.:. NP_002 DKCIPFWWKCDTEDDCGDHSDEPPDCPEFKCRPGQFQCST-GICTNPAFICDGDNDCQDN 3350 3360 3370 3380 3390 3400 90 100 110 120 130 pF1KE6 SDEEECRIE---P----CTQKGQCPPPPGLPCPCTGVSDCSGGTDKKLRNCSRLACLAGE ::: .: :. : ::. ..: : :. :.: ..:. : :. :.: ...: .. NP_002 SDEANCDIHVCLPSQFKCTNTNRCIP--GI-FRCNGQDNCGDGEDE--RDCPEVTCAPNQ 3410 3420 3430 3440 3450 140 150 160 170 180 190 pF1KE6 LRCTLSDDCIPLTWRCDGHPDCPDSSDE------LGCGTNEILPEGDATTMGPPVTLESV ..:... ::: .: :: :: :.::: . ::..: NP_002 FQCSITKRCIPRVWVCDRDNDCVDGSDEPANCTQMTCGVDEFRCKDSGRCIPARWKCDGE 3460 3470 3480 3490 3500 3510 200 210 220 230 240 250 pF1KE6 TSLRNATTMGPPVTLESVPSVGNATSSSAGDQSGSPTAYGVIAAAAVLSASLVTATLLLL NP_002 DDCGDGSDEPKEECDERTCEPYQFRCKNNRCVPGRWQCDYDNDCGDNSDEESCTPRPCSE 3520 3530 3540 3550 3560 3570 >-- initn: 309 init1: 160 opt: 280 Z-score: 231.5 bits: 54.7 E(85289): 3.7e-06 Smith-Waterman score: 301; 34.1% identity (52.3% similar) in 132 aa overlap (48-170:2690-2815) 20 30 40 50 60 70 pF1KE6 GLALLLLLGLGLGLEAAASPLSTPTSAQAAGPSSGSCPPTKFQCRTSGLCVPLTWRCDRD : . :: . : : :: :.:..: ::.. NP_002 CERTSLCYAPSWVCDGANDCGDYSDERDCPGVKRPRCPLNYFAC-PSGRCIPMSWTCDKE 2660 2670 2680 2690 2700 2710 80 90 100 110 120 130 pF1KE6 LDCSDGSDEEECRIEPCT------QKGQCPPPPGLPCPCTGVSDCSGGTDKKLRNCSRLA :: : :: .: . :. :. .: : : : .::. :.:. .: . NP_002 DDCEHGEDETHCN-KFCSEAQFECQNHRCISKQWL---CDGSDDCGDGSDEAA-HCEGKT 2720 2730 2740 2750 2760 2770 140 150 160 170 180 pF1KE6 CLAGELRCTLSDDCIPLTWRCDGHPDCPDSSDE---LGCGTNEILPEGDATTMGPPVTLE : . . : . :.: : ::: :: :..:: :: : NP_002 CGPSSFSCPGTHVCVPERWLCDGDKDCADGADESIAAGCLYNSTCDDREFMCQNRQCIPK 2780 2790 2800 2810 2820 2830 190 200 210 220 230 240 pF1KE6 SVTSLRNATTMGPPVTLESVPSVGNATSSSAGDQSGSPTAYGVIAAAAVLSASLVTATLL NP_002 HFVCDHDRDCADGSDESPECEYPTCGPSEFRCANGRCLSSRQWECDGENDCHDQSDEAPK 2840 2850 2860 2870 2880 2890 >-- initn: 284 init1: 154 opt: 237 Z-score: 195.8 bits: 48.1 E(85289): 0.00036 Smith-Waterman score: 237; 35.5% identity (50.0% similar) in 138 aa overlap (37-158:11-133) 10 20 30 40 50 60 pF1KE6 AQVGAWRTGALGLALLLLLGLGLGLEAAASPLSTPTSAQAAGPSSGSCPPTKFQCRTSGL :: . : :: . .: : .: :: . NP_002 MLTPPLLLLLPLLSALVA-AAIDAPKTCSPKQFACRDQIT 10 20 30 70 80 90 100 110 pF1KE6 CVPLTWRCDRDLDCSDGSDEEECRIEPCTQKGQCPPPP----GLP-C-P----CTGVSDC :. :::: . :: ::::: .: : .. .: : : : : :.::.:: NP_002 CISKGWRCDGERDCPDGSDEAP-EICPQSKAQRCQPNEHNCLGTELCVPMSRLCNGVQDC 40 50 60 70 80 90 120 130 140 150 160 170 pF1KE6 SGGTD-----KKLR-NCSRLACLAGELRCTLSDDCIPLTWRCDGHPDCPDSSDELGCGTN :.: ..:. :::::.: . :.: :: : : NP_002 MDGSDEGPHCRELQGNCSRLGC---------QHHCVPTL---DG-PTCYCNSSFQLQADG 100 110 120 130 140 180 190 200 210 220 230 pF1KE6 EILPEGDATTMGPPVTLESVTSLRNATTMGPPVTLESVPSVGNATSSSAGDQSGSPTAYG NP_002 KTCKDFDECSVYGTCSQLCTNTDGSFICGCVEGYLLQPDNRSCKAKNEPVDRPPVLLIAN 150 160 170 180 190 200 >>XP_016874792 (OMIM: 107770) PREDICTED: prolow-density (4561 aa) initn: 470 init1: 202 opt: 330 Z-score: 272.9 bits: 62.4 E(85289): 1.8e-08 Smith-Waterman score: 334; 34.9% identity (52.1% similar) in 169 aa overlap (43-188:1069-1230) 20 30 40 50 60 70 pF1KE6 RTGALGLALLLLLGLGLGLEAAASPLSTPTSAQAAGPSSGSCPPTKFQCRTSGLCVPLTW . ::. : :.: .:::: .:::.:: : XP_016 CNSGRCIPEHWTCDGDNDCGDYSDETHANCTNQATRPP-GGCHTDEFQCRLDGLCIPLRW 1040 1050 1060 1070 1080 1090 80 90 100 110 120 pF1KE6 RCDRDLDCSDGSDEEECRIEPCTQKGQCPPPPGLPCP-----------CTGVSDCSGGTD ::: : :: :.:::. : : :. : : . : : : .:: ..: XP_016 RCDGDTDCMDSSDEKSC--EGVTH--VCDPSVKFGCKDSARCISKAWVCDGDNDCEDNSD 1100 1110 1120 1130 1140 1150 130 140 150 160 pF1KE6 KKLRNCSRLACLAGELRCTLSDD-CIPLTWRCDGHPDCPDSSDEL-----------GCGT .. :: ::: :. . . :.: :::. :: :.::: ::. XP_016 EE--NCESLACRPPSHPCANNTSVCLPPDKLCDGNDDCGDGSDEGELCDQCSLNNGGCSH 1160 1170 1180 1190 1200 1210 170 180 190 200 210 220 pF1KE6 NEILPEGDATTMGPPVTLESVTSLRNATTMGPPVTLESVPSVGNATSSSAGDQSGSPTAY : . :.. . . :. .: XP_016 NCSVAPGEGIVCSCPLGMELGPDNHTCQIQSYCAKHLKCSQKCDQNKFSVKCSCYEGWVL 1220 1230 1240 1250 1260 1270 >-- initn: 439 init1: 175 opt: 322 Z-score: 266.3 bits: 61.1 E(85289): 4.3e-08 Smith-Waterman score: 360; 41.5% identity (61.8% similar) in 123 aa overlap (53-169:3552-3666) 30 40 50 60 70 80 pF1KE6 LLLGLGLGLEAAASPLSTPTSAQAAGPSSGSCPPTKFQCRTSGLCVPLTWRCDRDLDCSD .: : .:.:... ::: :.:: : ::.: XP_016 GRCIPARWKCDGEDDCGDGSDEPKEECDERTCEPYQFRCKNNR-CVPGRWQCDYDNDCGD 3530 3540 3550 3560 3570 3580 90 100 110 120 130 pF1KE6 GSDEEECRIEPCTQK------GQCPPPPGLPCPCTGVSDCSGGTDKKLRNCSRLACLAGE .:::: : .::... :.: : : ::. :.:.: .:. : . XP_016 NSDEESCTPRPCSESEFSCANGRCIAGRW---KCDGDHDCADGSDEK--DCTP-RCDMDQ 3590 3600 3610 3620 3630 140 150 160 170 180 190 pF1KE6 LRCTLSDDCIPLTWRCDGHPDCPDSSDELGCGTNEILPEGDATTMGPPVTLESVTSLRNA ..: : :::: ::::. :: :.::: .::: XP_016 FQCK-SGHCIPLRWRCDADADCMDGSDEEACGTGVRTCPLDEFQCNNTLCKPLAWKCDGE 3640 3650 3660 3670 3680 3690 200 210 220 230 240 250 pF1KE6 TTMGPPVTLESVPSVGNATSSSAGDQSGSPTAYGVIAAAAVLSASLVTATLLLLSWLRAQ XP_016 DDCGDNSDENPEECARFVCPPNRPFRCKNDRVCLWIGRQCDGTDNCGDGTDEEDCEPPTA 3700 3710 3720 3730 3740 3750 >-- initn: 332 init1: 175 opt: 322 Z-score: 266.3 bits: 61.1 E(85289): 4.3e-08 Smith-Waterman score: 323; 37.4% identity (63.4% similar) in 131 aa overlap (54-171:3391-3515) 30 40 50 60 70 80 pF1KE6 LLGLGLGLEAAASPLSTPTSAQAAGPSSGSCPPTKFQCRTSGLCVPLTWRCDRDLDCSDG : : .::: : :.:. .. :: : ::.:. XP_016 DKCIPFWWKCDTEDDCGDHSDEPPDCPEFKCRPGQFQCST-GICTNPAFICDGDNDCQDN 3370 3380 3390 3400 3410 90 100 110 120 130 pF1KE6 SDEEECRIE---P----CTQKGQCPPPPGLPCPCTGVSDCSGGTDKKLRNCSRLACLAGE ::: .: :. : ::. ..: : :. :.: ..:. : :. :.: ...: .. XP_016 SDEANCDIHVCLPSQFKCTNTNRCIP--GI-FRCNGQDNCGDGEDE--RDCPEVTCAPNQ 3420 3430 3440 3450 3460 3470 140 150 160 170 180 190 pF1KE6 LRCTLSDDCIPLTWRCDGHPDCPDSSDE------LGCGTNEILPEGDATTMGPPVTLESV ..:... ::: .: :: :: :.::: . ::..: XP_016 FQCSITKRCIPRVWVCDRDNDCVDGSDEPANCTQMTCGVDEFRCKDSGRCIPARWKCDGE 3480 3490 3500 3510 3520 3530 200 210 220 230 240 250 pF1KE6 TSLRNATTMGPPVTLESVPSVGNATSSSAGDQSGSPTAYGVIAAAAVLSASLVTATLLLL XP_016 DDCGDGSDEPKEECDERTCEPYQFRCKNNRCVPGRWQCDYDNDCGDNSDEESCTPRPCSE 3540 3550 3560 3570 3580 3590 >-- initn: 309 init1: 160 opt: 280 Z-score: 231.5 bits: 54.7 E(85289): 3.7e-06 Smith-Waterman score: 301; 34.1% identity (52.3% similar) in 132 aa overlap (48-170:2707-2832) 20 30 40 50 60 70 pF1KE6 GLALLLLLGLGLGLEAAASPLSTPTSAQAAGPSSGSCPPTKFQCRTSGLCVPLTWRCDRD : . :: . : : :: :.:..: ::.. XP_016 CERTSLCYAPSWVCDGANDCGDYSDERDCPGVKRPRCPLNYFAC-PSGRCIPMSWTCDKE 2680 2690 2700 2710 2720 2730 80 90 100 110 120 130 pF1KE6 LDCSDGSDEEECRIEPCT------QKGQCPPPPGLPCPCTGVSDCSGGTDKKLRNCSRLA :: : :: .: . :. :. .: : : : .::. :.:. .: . XP_016 DDCEHGEDETHCN-KFCSEAQFECQNHRCISKQWL---CDGSDDCGDGSDEAA-HCEGKT 2740 2750 2760 2770 2780 2790 140 150 160 170 180 pF1KE6 CLAGELRCTLSDDCIPLTWRCDGHPDCPDSSDE---LGCGTNEILPEGDATTMGPPVTLE : . . : . :.: : ::: :: :..:: :: : XP_016 CGPSSFSCPGTHVCVPERWLCDGDKDCADGADESIAAGCLYNSTCDDREFMCQNRQCIPK 2800 2810 2820 2830 2840 2850 190 200 210 220 230 240 pF1KE6 SVTSLRNATTMGPPVTLESVPSVGNATSSSAGDQSGSPTAYGVIAAAAVLSASLVTATLL XP_016 HFVCDHDRDCADGSDESPECEYPTCGPSEFRCANGRCLSSRQWECDGENDCHDQSDEAPK 2860 2870 2880 2890 2900 2910 >-- initn: 346 init1: 154 opt: 237 Z-score: 195.8 bits: 48.1 E(85289): 0.00036 Smith-Waterman score: 237; 35.5% identity (50.0% similar) in 138 aa overlap (37-158:11-133) 10 20 30 40 50 60 pF1KE6 AQVGAWRTGALGLALLLLLGLGLGLEAAASPLSTPTSAQAAGPSSGSCPPTKFQCRTSGL :: . : :: . .: : .: :: . XP_016 MLTPPLLLLLPLLSALVA-AAIDAPKTCSPKQFACRDQIT 10 20 30 70 80 90 100 110 pF1KE6 CVPLTWRCDRDLDCSDGSDEEECRIEPCTQKGQCPPPP----GLP-C-P----CTGVSDC :. :::: . :: ::::: .: : .. .: : : : : :.::.:: XP_016 CISKGWRCDGERDCPDGSDEAP-EICPQSKAQRCQPNEHNCLGTELCVPMSRLCNGVQDC 40 50 60 70 80 90 120 130 140 150 160 170 pF1KE6 SGGTD-----KKLR-NCSRLACLAGELRCTLSDDCIPLTWRCDGHPDCPDSSDELGCGTN :.: ..:. :::::.: . :.: :: : : XP_016 MDGSDEGPHCRELQGNCSRLGC---------QHHCVPTL---DG-PTCYCNSSFQLQADG 100 110 120 130 140 180 190 200 210 220 230 pF1KE6 EILPEGDATTMGPPVTLESVTSLRNATTMGPPVTLESVPSVGNATSSSAGDQSGSPTAYG XP_016 KTCKDFDECSVYGTCSQLCTNTDGSFICGCVEGYLLQPDNRSCKAKNEPVDRPPVLLIAN 150 160 170 180 190 200 >>XP_016859831 (OMIM: 608766) PREDICTED: low-density lip (2883 aa) initn: 808 init1: 212 opt: 321 Z-score: 267.9 bits: 60.8 E(85289): 3.5e-08 Smith-Waterman score: 346; 38.8% identity (62.8% similar) in 129 aa overlap (53-175:1600-1723) 30 40 50 60 70 80 pF1KE6 LLLGLGLGLEAAASPLSTPTSAQAAGPSSGSCPPTKFQCRTSGLCVPLTWRCDRDLDCSD .: ..:.:.:. :.:. :.:: ::.: XP_016 HLCLLAPGKTHTCACPTNFYLAADNRTCLSNCTASQFRCKTDK-CIPFWWKCDTVDDCGD 1570 1580 1590 1600 1610 1620 90 100 110 120 130 pF1KE6 GSDE-EECRIEPCTQKGQCPPPPGLPC--P---CTGVSDCSGGTDKKLRNCSRLACLAGE :::: ..: : : :. :: : : : : .::. ..:. ::. .::.:. XP_016 GSDEPDDCPEFRC-QPGRFQCGTGL-CALPAFICDGENDCGDNSDE--LNCDTHVCLSGQ 1630 1640 1650 1660 1670 1680 140 150 160 170 180 190 pF1KE6 LRCTLSDDCIPLTWRCDGHPDCPDSSDELGCGTNEILPEGDATTMGPPVTLESVTSLRNA ..:: .. :::.. ::.:. :: : :: : : :. XP_016 FKCTKNQKCIPVNLRCNGQDDCGDEEDERDCPENSCSPDYFQCKTTKHCISKLWVCDEDP 1690 1700 1710 1720 1730 1740 200 210 220 230 240 250 pF1KE6 TTMGPPVTLESVPSVGNATSSSAGDQSGSPTAYGVIAAAAVLSASLVTATLLLLSWLRAQ XP_016 DCADASDEANCDKKTCGPHEFQCKNNNCIPDHWRCDSQNDCSDNSDEENCKPQTCTLKDF 1750 1760 1770 1780 1790 1800 >-- initn: 808 init1: 212 opt: 321 Z-score: 267.9 bits: 60.8 E(85289): 3.5e-08 Smith-Waterman score: 364; 39.1% identity (61.7% similar) in 133 aa overlap (41-167:1744-1871) 20 30 40 50 60 pF1KE6 AWRTGALGLALLLLLGLGLGLEAAASPLSTPTSAQAAGPSS---GSCPPTKFQCRTSGLC : :.:. .. .: : .:::.... : XP_016 DCPENSCSPDYFQCKTTKHCISKLWVCDEDPDCADASDEANCDKKTCGPHEFQCKNNN-C 1720 1730 1740 1750 1760 1770 70 80 90 100 110 120 pF1KE6 VPLTWRCDRDLDCSDGSDEEECRIEPCTQKG-QCPPPPGLPCP--CTGVSDCSGGTDKKL .: :::: . ::::.::::.:. . :: : : . : : ::. :.:. XP_016 IPDHWRCDSQNDCSDNSDEENCKPQTCTLKDFLCANGDCVSSRFWCDGDFDCADGSDE-- 1780 1790 1800 1810 1820 1830 130 140 150 160 170 180 pF1KE6 RNCSRLACLAGELRCTLSDDCIPLTWRCDGHPDCPDSSDELGCGTNEILPEGDATTMGPP ::: . .: ..::. . .::: :.:::: :: . :: .: XP_016 RNC-ETSCSKDQFRCS-NGQCIPAKWKCDGHEDCKYGEDEKSCEPASPTCSSREYICASD 1840 1850 1860 1870 1880 190 200 210 220 230 240 pF1KE6 VTLESVTSLRNATTMGPPVTLESVPSVGNATSSSAGDQSGSPTAYGVIAAAAVLSASLVT XP_016 GCISASLKCNGEYDCADGSDEMDCVTECKEDQFRCKNKAHCIPIRWLCDGIHDCVDGSDE 1890 1900 1910 1920 1930 1940 >-- initn: 479 init1: 203 opt: 314 Z-score: 262.1 bits: 59.7 E(85289): 7.3e-08 Smith-Waterman score: 314; 37.5% identity (54.7% similar) in 128 aa overlap (54-175:966-1091) 30 40 50 60 70 80 pF1KE6 LLGLGLGLEAAASPLSTPTSAQAAGPSSGSCPPTKFQCRTSGLCVPLTWRCDRDLDCSDG : . :.: :: :. :: :: . :: :: XP_016 CVLPTWICDGSNDCGDYSDELKCPVQNKHKCEENYFSC-PSGRCILNTWICDGQKDCEDG 940 950 960 970 980 990 90 100 110 120 130 140 pF1KE6 SDEEECRIEPCT-QKGQCPPPPGLPCP--CTGVSDCSGGTDKKLRNCSRLACLAGELRCT :: .: :. .. : . : : .::. : :.. :. ..: : . : XP_016 RDEFHCD-SSCSWNQFACSAQKCISKHWICDGEDDCGDGLDESDSICGAITCAADMFSCQ 1000 1010 1020 1030 1040 1050 150 160 170 180 190 pF1KE6 LSDDCIPLTWRCDGHPDCPDSSDEL---GCGTNEILPEGDATTMGPPVTLESVTSLRNAT : :.: : :::. ::::.:::: ::. :. : XP_016 GSRACVPRHWLCDGERDCPDGSDELSTAGCAPNNTCDENAFMCHNKVCIPKQFVCDHDDD 1060 1070 1080 1090 1100 1110 200 210 220 230 240 250 pF1KE6 TMGPPVTLESVPSVGNATSSSAGDQSGSPTAYGVIAAAAVLSASLVTATLLLLSWLRAQE XP_016 CGDGSDESPQCGYRQCGTEEFSCADGRCLLNTQWQCDGDFDCPDHSDEAPLNPKCKSAEQ 1120 1130 1140 1150 1160 1170 >-- initn: 346 init1: 126 opt: 260 Z-score: 217.4 bits: 51.4 E(85289): 2.3e-05 Smith-Waterman score: 260; 35.4% identity (54.9% similar) in 113 aa overlap (67-167:848-958) 40 50 60 70 80 90 pF1KE6 PLSTPTSAQAAGPSSGSCPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECRIEPC-T :.: :: . ::.:.::: .:.. : : XP_016 PHCKDKSDEKLLYCENRSCRRGFKPCYNRRCIPHGKLCDGENDCGDNSDELDCKVSTCAT 820 830 840 850 860 870 100 110 120 130 140 pF1KE6 QKGQCPPPPGLP--CPCTGVSDCSGGTDKKLRNCSRLACL---------AGELRCTLSDD . .: .: :. ::. ..:.: ::. : .: .::. .. XP_016 VEFRCADGTCIPRSARCNQNIDCADASDEK--NCNNTDCTHFYKLGVKTTGFIRCNSTSL 880 890 900 910 920 930 150 160 170 180 190 200 pF1KE6 CIPLTWRCDGHPDCPDSSDELGCGTNEILPEGDATTMGPPVTLESVTSLRNATTMGPPVT :. :: ::: :: : :::: : XP_016 CVLPTWICDGSNDCGDYSDELKCPVQNKHKCEENYFSCPSGRCILNTWICDGQKDCEDGR 940 950 960 970 980 990 282 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 15:24:51 2016 done: Tue Nov 8 15:24:52 2016 Total Scan time: 7.360 Total Display time: 0.010 Function used was FASTA [36.3.4 Apr, 2011]