FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE5055, 197 aa 1>>>pF1KE5055 197 - 197 aa - 197 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.3901+/-0.000276; mu= 14.6976+/- 0.017 mean_var=89.1047+/-17.894, 0's: 0 Z-trim(121.0): 24 B-trim: 316 in 2/48 Lambda= 0.135870 statistics sampled from 36937 (36962) to 36937 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.779), E-opt: 0.2 (0.433), width: 16 Scan time: 5.870 The best scores are: opt bits E(85289) NP_004549 (OMIM: 602018) neurturin preproprotein [ ( 197) 1354 274.2 9.3e-74 XP_011526343 (OMIM: 602018) PREDICTED: neurturin i ( 197) 1354 274.2 9.3e-74 XP_011512332 (OMIM: 171300,209880,600837,613711) P ( 159) 336 74.6 9.3e-14 NP_001265027 (OMIM: 171300,209880,600837,613711) g ( 159) 336 74.6 9.3e-14 XP_016864826 (OMIM: 171300,209880,600837,613711) P ( 185) 336 74.7 1e-13 NP_954701 (OMIM: 171300,209880,600837,613711) glia ( 185) 336 74.7 1e-13 NP_001177398 (OMIM: 171300,209880,600837,613711) g ( 202) 336 74.7 1.1e-13 NP_000505 (OMIM: 171300,209880,600837,613711) glia ( 211) 336 74.7 1.1e-13 NP_001177397 (OMIM: 171300,209880,600837,613711) g ( 228) 336 74.7 1.2e-13 NP_476432 (OMIM: 603886) artemin isoform 1 preprop ( 220) 330 73.5 2.7e-13 NP_001129687 (OMIM: 603886) artemin isoform 3 [Hom ( 228) 330 73.6 2.7e-13 NP_476431 (OMIM: 603886) artemin isoform 3 [Homo s ( 228) 330 73.6 2.7e-13 NP_004149 (OMIM: 602921) persephin preproprotein [ ( 156) 298 67.1 1.6e-11 NP_004855 (OMIM: 605312) growth/differentiation fa ( 308) 173 42.9 0.00063 >>NP_004549 (OMIM: 602018) neurturin preproprotein [Homo (197 aa) initn: 1354 init1: 1354 opt: 1354 Z-score: 1445.2 bits: 274.2 E(85289): 9.3e-74 Smith-Waterman score: 1354; 100.0% identity (100.0% similar) in 197 aa overlap (1-197:1-197) 10 20 30 40 50 60 pF1KE5 MQRWKAAALASVLCSSVLSIWMCREGLLLSHRLGPALVPLHRLPRTLDARIARLAQYRAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 MQRWKAAALASVLCSSVLSIWMCREGLLLSHRLGPALVPLHRLPRTLDARIARLAQYRAL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 LQGAPDAMELRELTPWAGRPPGPRRRAGPRRRRARARLGARPCGLRELEVRVSELGLGYA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 LQGAPDAMELRELTPWAGRPPGPRRRAGPRRRRARARLGARPCGLRELEVRVSELGLGYA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE5 SDETVLFRYCAGACEAAARVYDLGLRRLRQRRRLRRERVRAQPCCRPTAYEDEVSFLDAH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 SDETVLFRYCAGACEAAARVYDLGLRRLRQRRRLRRERVRAQPCCRPTAYEDEVSFLDAH 130 140 150 160 170 180 190 pF1KE5 SRYHTVHELSARECACV ::::::::::::::::: NP_004 SRYHTVHELSARECACV 190 >>XP_011526343 (OMIM: 602018) PREDICTED: neurturin isofo (197 aa) initn: 1354 init1: 1354 opt: 1354 Z-score: 1445.2 bits: 274.2 E(85289): 9.3e-74 Smith-Waterman score: 1354; 100.0% identity (100.0% similar) in 197 aa overlap (1-197:1-197) 10 20 30 40 50 60 pF1KE5 MQRWKAAALASVLCSSVLSIWMCREGLLLSHRLGPALVPLHRLPRTLDARIARLAQYRAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MQRWKAAALASVLCSSVLSIWMCREGLLLSHRLGPALVPLHRLPRTLDARIARLAQYRAL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 LQGAPDAMELRELTPWAGRPPGPRRRAGPRRRRARARLGARPCGLRELEVRVSELGLGYA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LQGAPDAMELRELTPWAGRPPGPRRRAGPRRRRARARLGARPCGLRELEVRVSELGLGYA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE5 SDETVLFRYCAGACEAAARVYDLGLRRLRQRRRLRRERVRAQPCCRPTAYEDEVSFLDAH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SDETVLFRYCAGACEAAARVYDLGLRRLRQRRRLRRERVRAQPCCRPTAYEDEVSFLDAH 130 140 150 160 170 180 190 pF1KE5 SRYHTVHELSARECACV ::::::::::::::::: XP_011 SRYHTVHELSARECACV 190 >>XP_011512332 (OMIM: 171300,209880,600837,613711) PREDI (159 aa) initn: 322 init1: 156 opt: 336 Z-score: 368.0 bits: 74.6 E(85289): 9.3e-14 Smith-Waterman score: 336; 41.7% identity (71.3% similar) in 115 aa overlap (87-197:46-159) 60 70 80 90 100 110 pF1KE5 YRALLQGAPDAMELRELTPWAGRPPGPRRRAGPRRRRARARLGARP----CGLRELEVRV :.:. :...: : : : : ... : XP_011 IQATIKRLKRSPDKQMAVLPRRERNRQAAAANPENSRGKGRRGQRGKNRGCVLTAIHLNV 20 30 40 50 60 70 120 130 140 150 160 170 pF1KE5 SELGLGYASDETVLFRYCAGACEAAARVYDLGLRRLRQRRRLRRERVRAQPCCRPTAYED ..::::: . : ..::::.:.:.:: .:: :. : . ::: ..: .: :::: :..: XP_011 TDLGLGYETKEELIFRYCSGSCDAAETTYDKILKNLSRNRRLVSDKV-GQACCRPIAFDD 80 90 100 110 120 130 180 190 pF1KE5 EVSFLDAHSRYHTVHELSARECACV ..:::: . :: ... ::..:.:. XP_011 DLSFLDDNLVYHILRKHSAKRCGCI 140 150 >>NP_001265027 (OMIM: 171300,209880,600837,613711) glial (159 aa) initn: 322 init1: 156 opt: 336 Z-score: 368.0 bits: 74.6 E(85289): 9.3e-14 Smith-Waterman score: 336; 41.7% identity (71.3% similar) in 115 aa overlap (87-197:46-159) 60 70 80 90 100 110 pF1KE5 YRALLQGAPDAMELRELTPWAGRPPGPRRRAGPRRRRARARLGARP----CGLRELEVRV :.:. :...: : : : : ... : NP_001 IQATIKRLKRSPDKQMAVLPRRERNRQAAAANPENSRGKGRRGQRGKNRGCVLTAIHLNV 20 30 40 50 60 70 120 130 140 150 160 170 pF1KE5 SELGLGYASDETVLFRYCAGACEAAARVYDLGLRRLRQRRRLRRERVRAQPCCRPTAYED ..::::: . : ..::::.:.:.:: .:: :. : . ::: ..: .: :::: :..: NP_001 TDLGLGYETKEELIFRYCSGSCDAAETTYDKILKNLSRNRRLVSDKV-GQACCRPIAFDD 80 90 100 110 120 130 180 190 pF1KE5 EVSFLDAHSRYHTVHELSARECACV ..:::: . :: ... ::..:.:. NP_001 DLSFLDDNLVYHILRKHSAKRCGCI 140 150 >>XP_016864826 (OMIM: 171300,209880,600837,613711) PREDI (185 aa) initn: 322 init1: 156 opt: 336 Z-score: 367.1 bits: 74.7 E(85289): 1e-13 Smith-Waterman score: 336; 41.7% identity (71.3% similar) in 115 aa overlap (87-197:72-185) 60 70 80 90 100 110 pF1KE5 YRALLQGAPDAMELRELTPWAGRPPGPRRRAGPRRRRARARLGARP----CGLRELEVRV :.:. :...: : : : : ... : XP_016 IQATIKRLKRSPDKQMAVLPRRERNRQAAAANPENSRGKGRRGQRGKNRGCVLTAIHLNV 50 60 70 80 90 100 120 130 140 150 160 170 pF1KE5 SELGLGYASDETVLFRYCAGACEAAARVYDLGLRRLRQRRRLRRERVRAQPCCRPTAYED ..::::: . : ..::::.:.:.:: .:: :. : . ::: ..: .: :::: :..: XP_016 TDLGLGYETKEELIFRYCSGSCDAAETTYDKILKNLSRNRRLVSDKV-GQACCRPIAFDD 110 120 130 140 150 160 180 190 pF1KE5 EVSFLDAHSRYHTVHELSARECACV ..:::: . :: ... ::..:.:. XP_016 DLSFLDDNLVYHILRKHSAKRCGCI 170 180 >>NP_954701 (OMIM: 171300,209880,600837,613711) glial ce (185 aa) initn: 322 init1: 156 opt: 336 Z-score: 367.1 bits: 74.7 E(85289): 1e-13 Smith-Waterman score: 336; 41.7% identity (71.3% similar) in 115 aa overlap (87-197:72-185) 60 70 80 90 100 110 pF1KE5 YRALLQGAPDAMELRELTPWAGRPPGPRRRAGPRRRRARARLGARP----CGLRELEVRV :.:. :...: : : : : ... : NP_954 IQATIKRLKRSPDKQMAVLPRRERNRQAAAANPENSRGKGRRGQRGKNRGCVLTAIHLNV 50 60 70 80 90 100 120 130 140 150 160 170 pF1KE5 SELGLGYASDETVLFRYCAGACEAAARVYDLGLRRLRQRRRLRRERVRAQPCCRPTAYED ..::::: . : ..::::.:.:.:: .:: :. : . ::: ..: .: :::: :..: NP_954 TDLGLGYETKEELIFRYCSGSCDAAETTYDKILKNLSRNRRLVSDKV-GQACCRPIAFDD 110 120 130 140 150 160 180 190 pF1KE5 EVSFLDAHSRYHTVHELSARECACV ..:::: . :: ... ::..:.:. NP_954 DLSFLDDNLVYHILRKHSAKRCGCI 170 180 >>NP_001177398 (OMIM: 171300,209880,600837,613711) glial (202 aa) initn: 324 init1: 156 opt: 336 Z-score: 366.6 bits: 74.7 E(85289): 1.1e-13 Smith-Waterman score: 336; 41.7% identity (71.3% similar) in 115 aa overlap (87-197:89-202) 60 70 80 90 100 110 pF1KE5 YRALLQGAPDAMELRELTPWAGRPPGPRRRAGPRRRRARARLGARP----CGLRELEVRV :.:. :...: : : : : ... : NP_001 IQATIKRLKRSPDKQMAVLPRRERNRQAAAANPENSRGKGRRGQRGKNRGCVLTAIHLNV 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE5 SELGLGYASDETVLFRYCAGACEAAARVYDLGLRRLRQRRRLRRERVRAQPCCRPTAYED ..::::: . : ..::::.:.:.:: .:: :. : . ::: ..: .: :::: :..: NP_001 TDLGLGYETKEELIFRYCSGSCDAAETTYDKILKNLSRNRRLVSDKV-GQACCRPIAFDD 120 130 140 150 160 170 180 190 pF1KE5 EVSFLDAHSRYHTVHELSARECACV ..:::: . :: ... ::..:.:. NP_001 DLSFLDDNLVYHILRKHSAKRCGCI 180 190 200 >>NP_000505 (OMIM: 171300,209880,600837,613711) glial ce (211 aa) initn: 321 init1: 156 opt: 336 Z-score: 366.3 bits: 74.7 E(85289): 1.1e-13 Smith-Waterman score: 336; 41.7% identity (71.3% similar) in 115 aa overlap (87-197:98-211) 60 70 80 90 100 110 pF1KE5 YRALLQGAPDAMELRELTPWAGRPPGPRRRAGPRRRRARARLGARP----CGLRELEVRV :.:. :...: : : : : ... : NP_000 IQATIKRLKRSPDKQMAVLPRRERNRQAAAANPENSRGKGRRGQRGKNRGCVLTAIHLNV 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE5 SELGLGYASDETVLFRYCAGACEAAARVYDLGLRRLRQRRRLRRERVRAQPCCRPTAYED ..::::: . : ..::::.:.:.:: .:: :. : . ::: ..: .: :::: :..: NP_000 TDLGLGYETKEELIFRYCSGSCDAAETTYDKILKNLSRNRRLVSDKV-GQACCRPIAFDD 130 140 150 160 170 180 180 190 pF1KE5 EVSFLDAHSRYHTVHELSARECACV ..:::: . :: ... ::..:.:. NP_000 DLSFLDDNLVYHILRKHSAKRCGCI 190 200 210 >>NP_001177397 (OMIM: 171300,209880,600837,613711) glial (228 aa) initn: 321 init1: 156 opt: 336 Z-score: 365.9 bits: 74.7 E(85289): 1.2e-13 Smith-Waterman score: 336; 41.7% identity (71.3% similar) in 115 aa overlap (87-197:115-228) 60 70 80 90 100 110 pF1KE5 YRALLQGAPDAMELRELTPWAGRPPGPRRRAGPRRRRARARLGARP----CGLRELEVRV :.:. :...: : : : : ... : NP_001 IQATIKRLKRSPDKQMAVLPRRERNRQAAAANPENSRGKGRRGQRGKNRGCVLTAIHLNV 90 100 110 120 130 140 120 130 140 150 160 170 pF1KE5 SELGLGYASDETVLFRYCAGACEAAARVYDLGLRRLRQRRRLRRERVRAQPCCRPTAYED ..::::: . : ..::::.:.:.:: .:: :. : . ::: ..: .: :::: :..: NP_001 TDLGLGYETKEELIFRYCSGSCDAAETTYDKILKNLSRNRRLVSDKV-GQACCRPIAFDD 150 160 170 180 190 200 180 190 pF1KE5 EVSFLDAHSRYHTVHELSARECACV ..:::: . :: ... ::..:.:. NP_001 DLSFLDDNLVYHILRKHSAKRCGCI 210 220 >>NP_476432 (OMIM: 603886) artemin isoform 1 preproprote (220 aa) initn: 353 init1: 159 opt: 330 Z-score: 359.7 bits: 73.5 E(85289): 2.7e-13 Smith-Waterman score: 330; 41.1% identity (53.1% similar) in 207 aa overlap (4-197:24-219) 10 20 30 pF1KE5 MQRWKA-AALASVLCSSVLSIWMCREGLLLSHRLGPALV- : . :::: : ::: . . : :: : NP_476 MELGLGGLSTLSHCPWPRQQPALWPTLAALA--LLSSVAEASLGSAPRSPAPREGPPPVL 10 20 30 40 50 40 50 60 70 80 90 pF1KE5 --PLHRLPRTLDARIARLAQYRALLQGAPDAMELRELTPWAGRPPG--PR----RRAGPR : .:: .: :: . :: : . : : . ::. :: ::: NP_476 ASPAGHLP---GGRTARWCSGRAR---RPPPQPSRPAPPPPA-PPSALPRGGRAARAGGP 60 70 80 90 100 110 100 110 120 130 140 150 pF1KE5 RRRARARLGARPCGLRELEVRVSELGLGYASDETVLFRYCAGACEAAARVYDLGLRRLRQ :::: ::: : :: : : ::::. ::: : ::.:.:.:. : .::.: : NP_476 GSRARAA-GARGCRLRSQLVPVRALGLGHRSDELVRFRFCSGSCRRARSPHDLSLASLLG 120 130 140 150 160 170 160 170 180 190 pF1KE5 RRRLRRE---RVRAQPCCRPTAYEDEVSFLDAHSRYHTVHELSARECACV :: : .::::::: :: :::.:..: ..:: .::: :.:. NP_476 AGALRPPPGSRPVSQPCCRPTRYE-AVSFMDVNSTWRTVDRLSATACGCLG 180 190 200 210 220 197 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 04:35:27 2016 done: Tue Nov 8 04:35:27 2016 Total Scan time: 5.870 Total Display time: 0.000 Function used was FASTA [36.3.4 Apr, 2011]