FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE1750, 253 aa 1>>>pF1KE1750 253 - 253 aa - 253 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.8591+/-0.000311; mu= 17.7933+/- 0.019 mean_var=72.6246+/-14.671, 0's: 0 Z-trim(117.6): 308 B-trim: 112 in 1/51 Lambda= 0.150499 statistics sampled from 29483 (29800) to 29483 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.727), E-opt: 0.2 (0.349), width: 16 Scan time: 6.430 The best scores are: opt bits E(85289) NP_001919 (OMIM: 134350,613912) complement factor ( 253) 1744 387.3 1.4e-107 NP_001304264 (OMIM: 134350,613912) complement fact ( 260) 1720 382.1 5.4e-106 NP_005308 (OMIM: 600311) granzyme M isoform 1 prep ( 257) 644 148.4 1.1e-35 NP_002095 (OMIM: 600784) granzyme K precursor [Hom ( 264) 628 145.0 1.3e-34 NP_006135 (OMIM: 140050) granzyme A precursor [Hom ( 262) 621 143.5 3.7e-34 NP_001012982 (OMIM: 602652) kallikrein-6 isoform A ( 244) 605 140.0 3.9e-33 NP_002765 (OMIM: 602652) kallikrein-6 isoform A pr ( 244) 605 140.0 3.9e-33 NP_009127 (OMIM: 605644) kallikrein-8 isoform 1 pr ( 260) 596 138.0 1.6e-32 NP_653088 (OMIM: 605644) kallikrein-8 isoform 2 pr ( 305) 589 136.6 5.1e-32 NP_001245280 (OMIM: 600311) granzyme M isoform 2 [ ( 218) 564 131.0 1.7e-30 NP_056411 (OMIM: 605505) kallikrein-13 precursor [ ( 277) 565 131.3 1.8e-30 NP_002760 (OMIM: 167800,276000,614044) trypsin-1 p ( 247) 564 131.1 1.9e-30 XP_011514713 (OMIM: 167800,276000,614044) PREDICTE ( 472) 566 131.7 2.2e-30 NP_002762 (OMIM: 613578) trypsin-3 isoform 2 prepr ( 247) 553 128.7 9.8e-30 NP_001827 (OMIM: 118938) chymase isoform 1 preprop ( 247) 547 127.4 2.4e-29 NP_031369 (OMIM: 613578) trypsin-3 isoform 1 prepr ( 304) 547 127.5 2.8e-29 NP_001184027 (OMIM: 613578) trypsin-3 isoform 4 pr ( 240) 544 126.7 3.7e-29 NP_001184026 (OMIM: 613578) trypsin-3 isoform 3 pr ( 261) 543 126.5 4.6e-29 NP_071329 (OMIM: 606135) kallikrein-14 preproprote ( 267) 538 125.4 9.9e-29 NP_001298111 (OMIM: 606135) kallikrein-14 prepropr ( 267) 538 125.4 9.9e-29 XP_011516267 (OMIM: 613578) PREDICTED: trypsin-3 i ( 333) 539 125.8 1e-28 NP_219491 (OMIM: 116831) granzyme H isoform 1 prep ( 246) 537 125.2 1.1e-28 NP_001332940 (OMIM: 123910) granzyme B isoform 2 [ ( 235) 533 124.3 1.9e-28 NP_002761 (OMIM: 167800,601564) trypsin-2 isoform ( 247) 530 123.7 3.1e-28 NP_004122 (OMIM: 123910) granzyme B isoform 1 prep ( 247) 528 123.2 4.2e-28 NP_665901 (OMIM: 605539) kallikrein-12 isoform 2 p ( 248) 528 123.2 4.2e-28 NP_001129504 (OMIM: 604434) kallikrein-11 isoform ( 250) 522 121.9 1.1e-27 NP_006844 (OMIM: 604434) kallikrein-11 isoform 1 p ( 250) 522 121.9 1.1e-27 XP_011534801 (OMIM: 116830) PREDICTED: cathepsin G ( 269) 522 122.0 1.1e-27 NP_659196 (OMIM: 604434) kallikrein-11 isoform 2 [ ( 282) 522 122.0 1.1e-27 NP_001902 (OMIM: 116830) cathepsin G preproprotein ( 255) 518 121.1 1.9e-27 NP_005542 (OMIM: 147960) kallikrein-2 isoform 1 pr ( 261) 516 120.7 2.7e-27 NP_001898 (OMIM: 118888) chymotrypsin-like proteas ( 264) 511 119.6 5.7e-27 NP_001182058 (OMIM: 613517,613858) serine protease ( 603) 508 119.3 1.6e-26 NP_004908 (OMIM: 204700,603767) kallikrein-4 isofo ( 254) 500 117.2 2.9e-26 NP_062544 (OMIM: 605539) kallikrein-12 isoform 1 p ( 254) 500 117.2 2.9e-26 NP_001639 (OMIM: 176820) prostate-specific antigen ( 261) 494 115.9 7.3e-26 NP_001275930 (OMIM: 206200,609862) transmembrane p ( 802) 499 117.4 7.9e-26 NP_705837 (OMIM: 206200,609862) transmembrane prot ( 811) 499 117.4 7.9e-26 NP_002248 (OMIM: 147910,615953) kallikrein-1 prepr ( 262) 493 115.7 8.6e-26 NP_036447 (OMIM: 605504) kallikrein-9 precursor [H ( 250) 488 114.6 1.8e-25 NP_001897 (OMIM: 118890) chymotrypsinogen B isofor ( 263) 480 112.8 6.1e-25 NP_001243246 (OMIM: 605511) transmembrane protease ( 453) 480 113.1 9e-25 NP_036599 (OMIM: 609341) tryptase gamma preproprot ( 321) 476 112.1 1.3e-24 NP_254275 (OMIM: 609443) chymotrypsin-like elastas ( 269) 474 111.6 1.5e-24 NP_115780 (OMIM: 605511) transmembrane protease se ( 327) 474 111.6 1.8e-24 NP_001962 (OMIM: 130120) chymotrypsin-like elastas ( 258) 472 111.1 2e-24 NP_076927 (OMIM: 605511) transmembrane protease se ( 454) 474 111.8 2.2e-24 XP_011520748 (OMIM: 609341) PREDICTED: tryptase ga ( 346) 472 111.2 2.5e-24 XP_011520749 (OMIM: 609341) PREDICTED: tryptase ga ( 346) 472 111.2 2.5e-24 >>NP_001919 (OMIM: 134350,613912) complement factor D is (253 aa) initn: 1744 init1: 1744 opt: 1744 Z-score: 2052.2 bits: 387.3 E(85289): 1.4e-107 Smith-Waterman score: 1744; 100.0% identity (100.0% similar) in 253 aa overlap (1-253:1-253) 10 20 30 40 50 60 pF1KE1 MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQW 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 VLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 SEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCN 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 RRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTR 190 200 210 220 230 240 250 pF1KE1 VASYAAWIDSVLA ::::::::::::: NP_001 VASYAAWIDSVLA 250 >>NP_001304264 (OMIM: 134350,613912) complement factor D (260 aa) initn: 1730 init1: 1623 opt: 1720 Z-score: 2023.9 bits: 382.1 E(85289): 5.4e-106 Smith-Waterman score: 1720; 97.3% identity (97.3% similar) in 260 aa overlap (1-253:1-260) 10 20 30 40 50 pF1KE1 MHSWERLAVLVLLGAAAC-------AAPPRGRILGGREAEAHARPYMASVQLNGAHLCGG :::::::::::::::::: ::::::::::::::::::::::::::::::::::: NP_001 MHSWERLAVLVLLGAAACGEEAWAWAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGG 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE1 VLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDH 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE1 DLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPV 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE1 LDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRK 190 200 210 220 230 240 240 250 pF1KE1 KPGIYTRVASYAAWIDSVLA :::::::::::::::::::: NP_001 KPGIYTRVASYAAWIDSVLA 250 260 >>NP_005308 (OMIM: 600311) granzyme M isoform 1 prepropr (257 aa) initn: 513 init1: 237 opt: 644 Z-score: 761.4 bits: 148.4 E(85289): 1.1e-35 Smith-Waterman score: 644; 42.4% identity (68.8% similar) in 250 aa overlap (8-251:7-252) 10 20 30 40 50 pF1KE1 MHSWERLAVLVL-LGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQ ..::: ::: . .. .:.::::. :.::::::.: ::.:::::::: . NP_005 MEACVSSLLVLALGALSVGSSFGTQIIGGREVIPHSRPYMASLQRNGSHLCGGVLVHPK 10 20 30 40 50 60 70 80 90 100 110 pF1KE1 WVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQP-DTIDHDLLLL :::.::::: . ......:: :.:..: . . . :. :: .: ....:: :: NP_005 WVLTAAHCLAQRM-AQLRLVLGLHTLDSPGLT---FHIKAAIQHPRYKPVPALENDLALL 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE1 QLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRAT ::. :. . ..::: . :: :: :..::::.....:: :... : ::: NP_005 QLDGKVKPSRTIRPLALPSKRQVVAAGTRCSMAGWGLTHQGGRLSRVLRELDLQVLDTRM 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE1 CNRRTHHDGAITERLMCAESNRRDS--CKGDSGGPLVCGG--VLEGVVTSGSRVCGNRKK :: .:... ..: .. .:. :::::::::::: :: ::.. .:::: . : NP_005 CNNSRFWNGSLSPSMVCLAADSKDQAPCKGDSGGPLVCGKGRVLAGVLSFSSRVCTDIFK 180 190 200 210 220 230 240 250 pF1KE1 PGIYTRVASYAAWIDSVLA : . : :: :..:: .: NP_005 PPVATAVAPYVSWIRKVTGRSA 240 250 >>NP_002095 (OMIM: 600784) granzyme K precursor [Homo sa (264 aa) initn: 429 init1: 224 opt: 628 Z-score: 742.4 bits: 145.0 E(85289): 1.3e-34 Smith-Waterman score: 628; 42.7% identity (69.2% similar) in 234 aa overlap (26-252:27-258) 10 20 30 40 50 pF1KE1 MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQ :.::.:. :.::.:::.: .: :.:::::. : NP_002 MTKFSSFSLFFLIVGAYMTHVCFNMEIIGGKEVSPHSRPFMASIQYGGHHVCGGVLIDPQ 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE1 WVLSAAHCLEDAADGKVQ-VLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLL :::.:::: . :. :.:::::::. : ::. .. . .: : ..:..:. NP_002 WVLTAAHCQYRFTKGQSPTVVLGAHSLSKNEASKQTLEIKKFIPFSRVTSDPQSNDIMLV 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE1 QLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRP-DSLQHVLLPVLDRA .:. : :. :. : : .. :: : :.::: .. . :: :.:..: . ::.: NP_002 KLQTAAKLNKHVKMLHI-RSKTSLRSGTKCKVTGWGATDPDSLRPSDTLREVTVTVLSRK 130 140 150 160 170 180 190 200 210 220 230 pF1KE1 TCNRRTHHDGA--ITERLMCA--ESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRK :: .....: ::. ..:: ....:::::::::::.: ::....: ::.. :: NP_002 LCNSQSYYNGDPFITKDMVCAGDAKGQKDSCKGDSGGPLICKGVFHAIV-SGGHECGVAT 180 190 200 210 220 230 240 250 pF1KE1 KPGIYTRVAS-YAAWIDSVLA :::::: ... : .:: : : NP_002 KPGIYTLLTKKYQTWIKSNLVPPHTN 240 250 260 >>NP_006135 (OMIM: 140050) granzyme A precursor [Homo sa (262 aa) initn: 613 init1: 313 opt: 621 Z-score: 734.3 bits: 143.5 E(85289): 3.7e-34 Smith-Waterman score: 621; 41.3% identity (70.4% similar) in 230 aa overlap (25-248:28-254) 10 20 30 40 50 pF1KE1 MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVA .:.:: :. :.::::. ..:. .:.:.:.: NP_006 MRNSYRFLASSLSVVVSLLLIPEDVCEKIIGGNEVTPHSRPYMVLLSLDRKTICAGALIA 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE1 EQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLL ..:::.:::: . . ::.:::::... ::.:... : . :.: .: : . :: : NP_006 KDWVLTAAHC---NLNKRSQVILGAHSITREEPTKQIMLVKKEFPYPCYDPATREGDLKL 70 80 90 100 110 120 130 140 150 160 170 pF1KE1 LQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRA :::.::: .. : : . :: :::.:.::::: ..... :.:..: . ..:: NP_006 LQLTEKAKINKYVTILHLPKKGDDVKPGTMCQVAGWGRTHNSASWSDTLREVNITIIDRK 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE1 TCNRRTHHD--GAITERLMCAESNR--RDSCKGDSGGPLVCGGVLEGVVTSG-SRVCGNR .:: :.:.. .: ..:: : : ::::.::::.::.: ::..::.. : ::. NP_006 VCNDRNHYNFNPVIGMNMVCAGSLRGGRDSCNGDSGSPLLCEGVFRGVTSFGLENKCGDP 180 190 200 210 220 230 240 250 pF1KE1 KKPGIYTRVAS-YAAWIDSVLA . ::.: ... . :: NP_006 RGPGVYILLSKKHLNWIIMTIKGAV 240 250 260 >>NP_001012982 (OMIM: 602652) kallikrein-6 isoform A pre (244 aa) initn: 593 init1: 242 opt: 605 Z-score: 715.9 bits: 140.0 E(85289): 3.9e-33 Smith-Waterman score: 605; 39.0% identity (68.1% similar) in 251 aa overlap (5-252:2-241) 10 20 30 40 50 60 pF1KE1 MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQW ..: :.. : ::: : ..... : . ..::.:.. .: ::::::. : NP_001 MKKLMVVLSLIAAA-WAEEQNKLVHGGPCDKTSHPYQAALYTSGHLLCGGVLIHPLW 10 20 30 40 50 70 80 90 100 110 120 pF1KE1 VLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQL ::.:::: . ..::.:: :.: : : :.. .:.::: ::: . . :.:..::.: NP_001 VLTAAHCKKP----NLQVFLGKHNLRQRESSQEQSSVVRAVIHPDYDAASHDQDIMLLRL 60 70 80 90 100 110 130 140 150 160 170 pF1KE1 SEKATLGPAVRPLPWQRVDRDVAPGTL-CDVAGWGIVNHAGRRPDSLQHVLLPVLDRATC .. : :. ..::: ..:: . .: : . ::: . : ::..: . . ...: : NP_001 ARPAKLSELIQPLP---LERDCSANTTSCHILGWGKTAD-GDFPDTIQCAYIHLVSREEC 120 130 140 150 160 180 190 200 210 220 230 pF1KE1 NRRTHHDGAITERLMCA--ESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGI .. . : ::. ..:: :. .:::.:::::::::: :.:.:. :. ::...:::. NP_001 EHA--YPGQITQNMLCAGDEKYGKDSCQGDSGGPLVCGDHLRGLVSWGNIPCGSKEKPGV 170 180 190 200 210 220 240 250 pF1KE1 YTRVASYAAWIDSVLA :: : :. ::.... NP_001 YTNVCRYTNWIQKTIQAK 230 240 >>NP_002765 (OMIM: 602652) kallikrein-6 isoform A prepro (244 aa) initn: 593 init1: 242 opt: 605 Z-score: 715.9 bits: 140.0 E(85289): 3.9e-33 Smith-Waterman score: 605; 39.0% identity (68.1% similar) in 251 aa overlap (5-252:2-241) 10 20 30 40 50 60 pF1KE1 MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQW ..: :.. : ::: : ..... : . ..::.:.. .: ::::::. : NP_002 MKKLMVVLSLIAAA-WAEEQNKLVHGGPCDKTSHPYQAALYTSGHLLCGGVLIHPLW 10 20 30 40 50 70 80 90 100 110 120 pF1KE1 VLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQL ::.:::: . ..::.:: :.: : : :.. .:.::: ::: . . :.:..::.: NP_002 VLTAAHCKKP----NLQVFLGKHNLRQRESSQEQSSVVRAVIHPDYDAASHDQDIMLLRL 60 70 80 90 100 110 130 140 150 160 170 pF1KE1 SEKATLGPAVRPLPWQRVDRDVAPGTL-CDVAGWGIVNHAGRRPDSLQHVLLPVLDRATC .. : :. ..::: ..:: . .: : . ::: . : ::..: . . ...: : NP_002 ARPAKLSELIQPLP---LERDCSANTTSCHILGWGKTAD-GDFPDTIQCAYIHLVSREEC 120 130 140 150 160 180 190 200 210 220 230 pF1KE1 NRRTHHDGAITERLMCA--ESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGI .. . : ::. ..:: :. .:::.:::::::::: :.:.:. :. ::...:::. NP_002 EHA--YPGQITQNMLCAGDEKYGKDSCQGDSGGPLVCGDHLRGLVSWGNIPCGSKEKPGV 170 180 190 200 210 220 240 250 pF1KE1 YTRVASYAAWIDSVLA :: : :. ::.... NP_002 YTNVCRYTNWIQKTIQAK 230 240 >>NP_009127 (OMIM: 605644) kallikrein-8 isoform 1 prepro (260 aa) initn: 545 init1: 246 opt: 596 Z-score: 705.0 bits: 138.0 E(85289): 1.6e-32 Smith-Waterman score: 596; 37.5% identity (66.0% similar) in 256 aa overlap (3-252:11-256) 10 20 30 40 50 pF1KE1 MHSWERLAVLVLLGA-AACAAPPRGRILGGREAEAHARPYMASVQLNGAHLC .: . .:.: :: :. . . ..:::.: . :..:..:.. . :: NP_009 MGRPRPRAAKTW--MFLLLLGGAWAGHSRAQEDKVLGGHECQPHSQPWQAALFQGQQLLC 10 20 30 40 50 60 70 80 90 100 pF1KE1 GGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHP---DSQP :::::. .:::.:::: . : : :: :::.. . .. :....::: .:. NP_009 GGVLVGGNWVLTAAHCKKP----KYTVRLGDHSLQNKDGPEQEIPVVQSIPHPCYNSSDV 60 70 80 90 100 110 110 120 130 140 150 160 pF1KE1 DTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRR-PDSLQ . .:::.:::: ..:.:: :.:. .:. . :: : :.::: :. . ::.:. NP_009 EDHNHDLMLLQLRDQASLGSKVKPISL--ADHCTQPGQKCTVSGWGTVTSPRENFPDTLN 120 130 140 150 160 170 170 180 190 200 210 220 pF1KE1 HVLLPVLDRATCNRRTHHDGAITERLMCAESNR-RDSCKGDSGGPLVCGGVLEGVVTSGS . . .. . : . . : ::. ..:: :.. :.:.::::::::: :.:.:... :: NP_009 CAEVKIFPQKKC--EDAYPGQITDGMVCAGSSKGADTCQGDSGGPLVCDGALQGITSWGS 180 190 200 210 220 230 230 240 250 pF1KE1 RVCGNRKKPGIYTRVASYAAWIDSVLA :: :::.:: . : :: ... NP_009 DPCGRSDKPGVYTNICRYLDWIKKIIGSKG 240 250 260 >>NP_653088 (OMIM: 605644) kallikrein-8 isoform 2 precur (305 aa) initn: 531 init1: 246 opt: 589 Z-score: 695.9 bits: 136.6 E(85289): 5.1e-32 Smith-Waterman score: 589; 37.9% identity (66.7% similar) in 243 aa overlap (15-252:67-301) 10 20 30 40 pF1KE1 MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQ ::. . . ..:::.: . :..:..:.. NP_653 ENLPCVHLNPQWPSQPSHCPRGWRSNPLPPAAGHSRAQEDKVLGGHECQPHSQPWQAALF 40 50 60 70 80 90 50 60 70 80 90 100 pF1KE1 LNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHP . :::::::. .:::.:::: . : : :: :::.. . .. :....::: NP_653 QGQQLLCGGVLVGGNWVLTAAHCKKP----KYTVRLGDHSLQNKDGPEQEIPVVQSIPHP 100 110 120 130 140 150 110 120 130 140 150 160 pF1KE1 ---DSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGR .:. . .:::.:::: ..:.:: :.:. . .:. . :: : :.::: :. . NP_653 CYNSSDVEDHNHDLMLLQLRDQASLGSKVKPI--SLADHCTQPGQKCTVSGWGTVTSPRE 160 170 180 190 200 210 170 180 190 200 210 pF1KE1 R-PDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNR-RDSCKGDSGGPLVCGGVLE ::.:. . . .. . :. . : ::. ..:: :.. :.:.::::::::: :.:. NP_653 NFPDTLNCAEVKIFPQKKCE--DAYPGQITDGMVCAGSSKGADTCQGDSGGPLVCDGALQ 220 230 240 250 260 220 230 240 250 pF1KE1 GVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA :... :: :: :::.:: . : :: ... NP_653 GITSWGSDPCGRSDKPGVYTNICRYLDWIKKIIGSKG 270 280 290 300 >>NP_001245280 (OMIM: 600311) granzyme M isoform 2 [Homo (218 aa) initn: 437 init1: 200 opt: 564 Z-score: 668.4 bits: 131.0 E(85289): 1.7e-30 Smith-Waterman score: 564; 41.9% identity (68.2% similar) in 217 aa overlap (40-251:1-213) 10 20 30 40 50 60 pF1KE1 LVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLE :::.: ::.:::::::: .:::.::::: NP_001 MASLQRNGSHLCGGVLVHPKWVLTAAHCLA 10 20 30 70 80 90 100 110 120 pF1KE1 DAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQP-DTIDHDLLLLQLSEKATLGP . ......:: :.:..: . . . :. :: .: ....:: ::::. :. . NP_001 QRM-AQLRLVLGLHTLDSPGLT---FHIKAAIQHPRYKPVPALENDLALLQLDGKVKPSR 40 50 60 70 80 130 140 150 160 170 180 pF1KE1 AVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGA ..::: . :: :: :..::::.....:: :... : ::: :: .:. NP_001 TIRPLALPSKRQVVAAGTRCSMAGWGLTHQGGRLSRVLRELDLQVLDTRMCNNSRFWNGS 90 100 110 120 130 140 190 200 210 220 230 240 pF1KE1 ITERLMCAESNRRDS--CKGDSGGPLVCGG--VLEGVVTSGSRVCGNRKKPGIYTRVASY .. ..: .. .:. :::::::::::: :: ::.. .:::: . :: . : :: : NP_001 LSPSMVCLAADSKDQAPCKGDSGGPLVCGKGRVLAGVLSFSSRVCTDIFKPPVATAVAPY 150 160 170 180 190 200 250 pF1KE1 AAWIDSVLA ..:: .: NP_001 VSWIRKVTGRSA 210 253 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 13:37:24 2016 done: Sun Nov 6 13:37:25 2016 Total Scan time: 6.430 Total Display time: -0.010 Function used was FASTA [36.3.4 Apr, 2011]