FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE1752, 257 aa 1>>>pF1KE1752 257 - 257 aa - 257 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.3999+/-0.000327; mu= 13.8796+/- 0.020 mean_var=70.3096+/-14.388, 0's: 0 Z-trim(116.1): 298 B-trim: 89 in 2/49 Lambda= 0.152956 statistics sampled from 26737 (27052) to 26737 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.696), E-opt: 0.2 (0.317), width: 16 Scan time: 6.230 The best scores are: opt bits E(85289) NP_005308 (OMIM: 600311) granzyme M isoform 1 prep ( 257) 1735 391.7 6.9e-109 NP_001245280 (OMIM: 600311) granzyme M isoform 2 [ ( 218) 1486 336.7 2.1e-92 NP_001919 (OMIM: 134350,613912) complement factor ( 253) 644 150.9 2e-36 NP_001304264 (OMIM: 134350,613912) complement fact ( 260) 632 148.3 1.3e-35 NP_002095 (OMIM: 600784) granzyme K precursor [Hom ( 264) 571 134.8 1.5e-31 NP_004908 (OMIM: 204700,603767) kallikrein-4 isofo ( 254) 540 128.0 1.7e-29 NP_001243246 (OMIM: 605511) transmembrane protease ( 453) 541 128.3 2.3e-29 NP_115780 (OMIM: 605511) transmembrane protease se ( 327) 529 125.6 1.1e-28 NP_076927 (OMIM: 605511) transmembrane protease se ( 454) 529 125.7 1.4e-28 NP_219491 (OMIM: 116831) granzyme H isoform 1 prep ( 246) 505 120.3 3.4e-27 NP_001129504 (OMIM: 604434) kallikrein-11 isoform ( 250) 504 120.0 4e-27 NP_006844 (OMIM: 604434) kallikrein-11 isoform 1 p ( 250) 504 120.0 4e-27 NP_006135 (OMIM: 140050) granzyme A precursor [Hom ( 262) 504 120.0 4.2e-27 NP_659196 (OMIM: 604434) kallikrein-11 isoform 2 [ ( 282) 504 120.1 4.4e-27 NP_004122 (OMIM: 123910) granzyme B isoform 1 prep ( 247) 503 119.8 4.6e-27 NP_001332940 (OMIM: 123910) granzyme B isoform 2 [ ( 235) 501 119.4 6e-27 NP_001275679 (OMIM: 606751) transmembrane protease ( 413) 499 119.1 1.3e-26 NP_001902 (OMIM: 116830) cathepsin G preproprotein ( 255) 496 118.3 1.4e-26 NP_059979 (OMIM: 610601) kallikrein-15 isoform 4 p ( 256) 496 118.3 1.4e-26 XP_006723328 (OMIM: 610601) PREDICTED: kallikrein- ( 256) 496 118.3 1.4e-26 NP_001275680 (OMIM: 606751) transmembrane protease ( 448) 499 119.1 1.4e-26 NP_110397 (OMIM: 606751) transmembrane protease se ( 457) 499 119.1 1.4e-26 NP_001265514 (OMIM: 605236,614595) atrial natriure ( 938) 496 118.6 4.1e-26 NP_006578 (OMIM: 605236,614595) atrial natriuretic (1042) 496 118.6 4.4e-26 NP_001264010 (OMIM: 610601) kallikrein-15 isoform ( 255) 488 116.5 4.7e-26 XP_011525387 (OMIM: 610601) PREDICTED: kallikrein- ( 255) 488 116.5 4.7e-26 XP_011534801 (OMIM: 116830) PREDICTED: cathepsin G ( 269) 484 115.6 9.1e-26 NP_009127 (OMIM: 605644) kallikrein-8 isoform 1 pr ( 260) 481 115.0 1.4e-25 NP_056411 (OMIM: 605505) kallikrein-13 precursor [ ( 277) 480 114.8 1.7e-25 NP_001962 (OMIM: 130120) chymotrypsin-like elastas ( 258) 478 114.3 2.2e-25 NP_254275 (OMIM: 609443) chymotrypsin-like elastas ( 269) 478 114.3 2.3e-25 NP_000292 (OMIM: 173350,217090) plasminogen isofor ( 810) 480 115.0 4.2e-25 NP_653088 (OMIM: 605644) kallikrein-8 isoform 2 pr ( 305) 472 113.0 6.3e-25 NP_001275930 (OMIM: 206200,609862) transmembrane p ( 802) 476 114.1 7.6e-25 NP_705837 (OMIM: 206200,609862) transmembrane prot ( 811) 476 114.2 7.7e-25 NP_001898 (OMIM: 118888) chymotrypsin-like proteas ( 264) 469 112.3 8.9e-25 XP_011528035 (OMIM: 602060) PREDICTED: transmembra ( 384) 468 112.2 1.4e-24 XP_005261100 (OMIM: 602060) PREDICTED: transmembra ( 452) 468 112.2 1.6e-24 NP_005647 (OMIM: 602060) transmembrane protease se ( 492) 468 112.3 1.7e-24 XP_011528033 (OMIM: 602060) PREDICTED: transmembra ( 492) 468 112.3 1.7e-24 NP_001128571 (OMIM: 602060) transmembrane protease ( 529) 468 112.3 1.8e-24 NP_001277025 (OMIM: 606565) transmembrane protease ( 290) 464 111.2 2.1e-24 NP_036559 (OMIM: 605643) kallikrein-5 preproprotei ( 293) 464 111.2 2.1e-24 XP_011525004 (OMIM: 605643) PREDICTED: kallikrein- ( 293) 464 111.2 2.1e-24 XP_011525005 (OMIM: 605643) PREDICTED: kallikrein- ( 293) 464 111.2 2.1e-24 NP_001070960 (OMIM: 605643) kallikrein-5 prepropro ( 293) 464 111.2 2.1e-24 NP_001070959 (OMIM: 605643) kallikrein-5 prepropro ( 293) 464 111.2 2.1e-24 NP_001167023 (OMIM: 606565) transmembrane protease ( 397) 464 111.3 2.7e-24 NP_001277023 (OMIM: 606565) transmembrane protease ( 412) 464 111.3 2.8e-24 NP_001077416 (OMIM: 606565) transmembrane protease ( 432) 464 111.3 2.9e-24 >>NP_005308 (OMIM: 600311) granzyme M isoform 1 prepropr (257 aa) initn: 1735 init1: 1735 opt: 1735 Z-score: 2075.8 bits: 391.7 E(85289): 6.9e-109 Smith-Waterman score: 1735; 100.0% identity (100.0% similar) in 257 aa overlap (1-257:1-257) 10 20 30 40 50 60 pF1KE1 MEACVSSLLVLALGALSVGSSFGTQIIGGREVIPHSRPYMASLQRNGSHLCGGVLVHPKW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 MEACVSSLLVLALGALSVGSSFGTQIIGGREVIPHSRPYMASLQRNGSHLCGGVLVHPKW 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 VLTAAHCLAQRMAQLRLVLGLHTLDSPGLTFHIKAAIQHPRYKPVPALENDLALLQLDGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 VLTAAHCLAQRMAQLRLVLGLHTLDSPGLTFHIKAAIQHPRYKPVPALENDLALLQLDGK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 VKPSRTIRPLALPSKRQVVAAGTRCSMAGWGLTHQGGRLSRVLRELDLQVLDTRMCNNSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 VKPSRTIRPLALPSKRQVVAAGTRCSMAGWGLTHQGGRLSRVLRELDLQVLDTRMCNNSR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 FWNGSLSPSMVCLAADSKDQAPCKGDSGGPLVCGKGRVLAGVLSFSSRVCTDIFKPPVAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 FWNGSLSPSMVCLAADSKDQAPCKGDSGGPLVCGKGRVLAGVLSFSSRVCTDIFKPPVAT 190 200 210 220 230 240 250 pF1KE1 AVAPYVSWIRKVTGRSA ::::::::::::::::: NP_005 AVAPYVSWIRKVTGRSA 250 >>NP_001245280 (OMIM: 600311) granzyme M isoform 2 [Homo (218 aa) initn: 1486 init1: 1486 opt: 1486 Z-score: 1779.9 bits: 336.7 E(85289): 2.1e-92 Smith-Waterman score: 1486; 100.0% identity (100.0% similar) in 218 aa overlap (40-257:1-218) 10 20 30 40 50 60 pF1KE1 VLALGALSVGSSFGTQIIGGREVIPHSRPYMASLQRNGSHLCGGVLVHPKWVLTAAHCLA :::::::::::::::::::::::::::::: NP_001 MASLQRNGSHLCGGVLVHPKWVLTAAHCLA 10 20 30 70 80 90 100 110 120 pF1KE1 QRMAQLRLVLGLHTLDSPGLTFHIKAAIQHPRYKPVPALENDLALLQLDGKVKPSRTIRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QRMAQLRLVLGLHTLDSPGLTFHIKAAIQHPRYKPVPALENDLALLQLDGKVKPSRTIRP 40 50 60 70 80 90 130 140 150 160 170 180 pF1KE1 LALPSKRQVVAAGTRCSMAGWGLTHQGGRLSRVLRELDLQVLDTRMCNNSRFWNGSLSPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LALPSKRQVVAAGTRCSMAGWGLTHQGGRLSRVLRELDLQVLDTRMCNNSRFWNGSLSPS 100 110 120 130 140 150 190 200 210 220 230 240 pF1KE1 MVCLAADSKDQAPCKGDSGGPLVCGKGRVLAGVLSFSSRVCTDIFKPPVATAVAPYVSWI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MVCLAADSKDQAPCKGDSGGPLVCGKGRVLAGVLSFSSRVCTDIFKPPVATAVAPYVSWI 160 170 180 190 200 210 250 pF1KE1 RKVTGRSA :::::::: NP_001 RKVTGRSA >>NP_001919 (OMIM: 134350,613912) complement factor D is (253 aa) initn: 513 init1: 237 opt: 644 Z-score: 774.8 bits: 150.9 E(85289): 2e-36 Smith-Waterman score: 644; 42.4% identity (68.8% similar) in 250 aa overlap (7-252:8-251) 10 20 30 40 50 pF1KE1 MEACVSSLLVLALGALSVGSSFGTQIIGGREVIPHSRPYMASLQRNGSHLCGGVLVHPK ..::: ::: . .. .:.::::. :.::::::.: ::.:::::::: . NP_001 MHSWERLAVLVL-LGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQ 10 20 30 40 50 60 70 80 90 100 110 pF1KE1 WVLTAAHCLAQRM-AQLRLVLGLHTLDSPGLT---FHIKAAIQHPRYKPVPALENDLALL :::.::::: . ......:: :.:..: . . . :. :: .: ....:: :: NP_001 WVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQP-DTIDHDLLLL 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE1 QLDGKVKPSRTIRPLALPSKRQVVAAGTRCSMAGWGLTHQGGRLSRVLRELDLQVLDTRM ::. :. . ..::: . :: :: :..::::.....:: :... : ::: NP_001 QLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRAT 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE1 CNNSRFWNGSLSPSMVCLAADSKDQAPCKGDSGGPLVCGKGRVLAGVLSFSSRVCTDIFK :: .:... ..: .. .:. :::::::::::: :: ::.. .:::: . : NP_001 CNRRTHHDGAITERLMCAESNRRDS--CKGDSGGPLVCGG--VLEGVVTSGSRVCGNRKK 180 190 200 210 220 230 240 250 pF1KE1 PPVATAVAPYVSWIRKVTGRSA : . : :: :..:: .: NP_001 PGIYTRVASYAAWIDSVLA 240 250 >>NP_001304264 (OMIM: 134350,613912) complement factor D (260 aa) initn: 505 init1: 229 opt: 632 Z-score: 760.3 bits: 148.3 E(85289): 1.3e-35 Smith-Waterman score: 632; 43.5% identity (69.8% similar) in 232 aa overlap (25-252:32-258) 10 20 30 40 50 pF1KE1 MEACVSSLLVLALGALSVGSSFGTQIIGGREVIPHSRPYMASLQRNGSHLCGGV .:.::::. :.::::::.: ::.:::::: NP_001 HSWERLAVLVLLGAAACGEEAWAWAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGV 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE1 LVHPKWVLTAAHCLAQRM-AQLRLVLGLHTLDSPGLT---FHIKAAIQHPRYKPVPALEN :: .:::.::::: . ......:: :.:..: . . . :. :: .: .... NP_001 LVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQP-DTIDH 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE1 DLALLQLDGKVKPSRTIRPLALPSKRQVVAAGTRCSMAGWGLTHQGGRLSRVLRELDLQV :: ::::. :. . ..::: . :: :: :..::::.....:: :... : : NP_001 DLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPV 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE1 LDTRMCNNSRFWNGSLSPSMVCLAADSKDQAPCKGDSGGPLVCGKGRVLAGVLSFSSRVC :: :: .:... ..: .. .:. :::::::::::: : :: ::.. .:::: NP_001 LDRATCNRRTHHDGAITERLMCAESNRRDS--CKGDSGGPLVCG-G-VLEGVVTSGSRVC 190 200 210 220 230 240 250 pF1KE1 TDIFKPPVATAVAPYVSWIRKVTGRSA . :: . : :: :..:: .: NP_001 GNRKKPGIYTRVASYAAWIDSVLA 240 250 260 >>NP_002095 (OMIM: 600784) granzyme K precursor [Homo sa (264 aa) initn: 446 init1: 272 opt: 571 Z-score: 687.5 bits: 134.8 E(85289): 1.5e-31 Smith-Waterman score: 571; 40.2% identity (66.9% similar) in 254 aa overlap (7-250:8-255) 10 20 30 40 50 pF1KE1 MEACVSSLLVLALGALSVGSSFGTQIIGGREVIPHSRPYMASLQRNGSHLCGGVLVHPK ::. : .:: . :. .::::.:: :::::.:::.: .: :.:::::. :. NP_002 MTKFSSFSLFFLIVGAYMTHVCFNMEIIGGKEVSPHSRPFMASIQYGGHHVCGGVLIDPQ 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE1 WVLTAAHCLAQ--RMAQLRLVLGLHTL---DSPGLTFHIKAAIQHPRYKPVPALENDLAL :::::::: . . . .::: :.: .. :..:: : : : ::. : NP_002 WVLTAAHCQYRFTKGQSPTVVLGAHSLSKNEASKQTLEIKKFIPFSRVTSDPQ-SNDIML 70 80 90 100 110 120 130 140 150 160 170 pF1KE1 LQLDGKVKPSRTIRPLALPSKRQVVAAGTRCSMAGWGLTHQGG-RLSRVLRELDLQVLDT ..:. .: .. .. : . :: .. .::.:...::: : . : : .:::. . ::. NP_002 VKLQTAAKLNKHVKMLHIRSKTSL-RSGTKCKVTGWGATDPDSLRPSDTLREVTVTVLSR 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE1 RMCNNSRFWNGS--LSPSMVCLAADSKDQAP-CKGDSGGPLVCGKGRVLAGVLSFSSRVC ..::.. ..::. .. .::: :.:.: : :::::::::.: :: :. ...: ... : NP_002 KLCNSQSYYNGDPFITKDMVC-AGDAKGQKDSCKGDSGGPLIC-KG-VFHAIVS-GGHEC 180 190 200 210 220 230 240 250 pF1KE1 TDIFKPPVATAVAP-YVSWIRKVTGRSA :: . : .. : .::. NP_002 GVATKPGIYTLLTKKYQTWIKSNLVPPHTN 240 250 260 >>NP_004908 (OMIM: 204700,603767) kallikrein-4 isoform 1 (254 aa) initn: 417 init1: 235 opt: 540 Z-score: 650.7 bits: 128.0 E(85289): 1.7e-29 Smith-Waterman score: 540; 38.8% identity (69.4% similar) in 255 aa overlap (9-256:15-254) 10 20 30 40 50 pF1KE1 MEACVSSLLVLAL-GALSVGSSFGTQIIGGREVIPHSRPYMASLQRNGSHLCGG :.:.. :.: :: .:::.:.. :::.:..:.: .. .:.: NP_004 MATAGNPWGWFLGYLILGVAGSLVSGSC--SQIINGEDCSPHSQPWQAALVMENELFCSG 10 20 30 40 50 60 70 80 90 100 pF1KE1 VLVHPKWVLTAAHCLAQRMAQLRLVLGLHTLDS---PGLTFHIKAA--IQHPRYKPVPAL :::::.:::.::::. . .. . ::::.:.. :: . ..:. ..::.:. : : NP_004 VLVHPQWVLSAAHCFQNSYT---IGLGLHSLEADQEPG-SQMVEASLSVRHPEYNR-PLL 60 70 80 90 100 110 110 120 130 140 150 160 pF1KE1 ENDLALLQLDGKVKPSRTIRPLALPSKRQVVAAGTRCSMAGWGLTHQGGRLSRVLRELDL ::: :..:: .:. : ::: ... : : .::. : ..:::: .::. ::. ... NP_004 ANDLMLIKLDESVSESDTIRSISIAS--QCPTAGNSCLVSGWGLL-ANGRMPTVLQCVNV 120 130 140 150 160 170 170 180 190 200 210 220 pF1KE1 QVLDTRMCNNSRFWNGSLSPSMVCLAADSKDQAP-CKGDSGGPLVCGKGRVLAGVLSFSS .:.. ..: :.... ::: : :. ..:: :.:::::::.:. : : :..::.. NP_004 SVVSEEVC--SKLYDPLYHPSMFC-AGGGQDQKDSCNGDSGGPLICN-GY-LQGLVSFGK 180 190 200 210 220 230 240 250 pF1KE1 RVCTDIFKPPVATAVAPYVSWIRKVTGRSA : .. : : : . .. ::.:.. : NP_004 APCGQVGVPGVYTNLCKFTEWIEKTVQAS 230 240 250 >>NP_001243246 (OMIM: 605511) transmembrane protease ser (453 aa) initn: 502 init1: 280 opt: 541 Z-score: 648.2 bits: 128.3 E(85289): 2.3e-29 Smith-Waterman score: 541; 34.8% identity (65.6% similar) in 256 aa overlap (2-251:192-445) 10 20 30 pF1KE1 MEACVSSLLV-LALGALSVGSSFGTQIIGGR :.:.:. .: : : . .....:.:: NP_001 EGQFREEFVSIDHLLPDDKVTALHHSVYVREGCASGHVVTLQCTACGHRRGYSSRIVGGN 170 180 190 200 210 220 40 50 60 70 80 pF1KE1 EVIPHSRPYMASLQRNGSHLCGGVLVHPKWVLTAAHCLAQRM--AQLRLVLGLHTL-DSP . . :..:::: .: ::::: .. : :..:::::. . . . . .:: .: :.: NP_001 MSLLSQWPWQASLQFQGYHLCGGSVITPLWIITAAHCVYDLYLPKSWTIQVGLVSLLDNP 230 240 250 260 270 280 90 100 110 120 130 140 pF1KE1 GLTFHIKAAIQHPRYKPVPALENDLALLQLDGKVKPSRTIRPLALPSKRQVVAAGTRCSM . . .. . : .::: : ::.::..: : . .. :.:. ::.... : : NP_001 APSHLVEKIVYHSKYKP-KRLGNDIALMKLAGPLTFNEMIQPVCLPNSEENFPDGKVCWT 290 300 310 320 330 340 150 160 170 180 190 200 pF1KE1 AGWGLTHQGGRLSRVLRELDLQVLDTRMCNNSRFWNGSLSPSMVCLAADSKDQAPCKGDS .::: :..:: : :: . . ......::. ..: .::::.: . . :.::: NP_001 SGWGATEDGGDASPVLNHAAVPLISNKICNHRDVYGGIISPSMLCAGYLTGGVDSCQGDS 350 360 370 380 390 400 210 220 230 240 250 pF1KE1 GGPLVCGKGRV--LAGVLSFSSRVCTDIFKPPVATAVAPYVSWIRKVTGRSA :::::: . :. :.:. ::. :... :: : : :. ...::.. NP_001 GGPLVCQERRLWKLVGATSFGIG-CAEVNKPGVYTRVTSFLDWIHEQMERDLKT 410 420 430 440 450 >>NP_115780 (OMIM: 605511) transmembrane protease serine (327 aa) initn: 462 init1: 160 opt: 529 Z-score: 636.0 bits: 125.6 E(85289): 1.1e-28 Smith-Waterman score: 529; 34.6% identity (65.4% similar) in 257 aa overlap (2-251:65-319) 10 20 30 pF1KE1 MEACVSSLLV-LALGALSVGSSFGTQIIGGR :.:.:. .: : : . .....:.:: NP_115 EGQFREEFVSIDHLLPDDKVTALHHSVYVREGCASGHVVTLQCTACGHRRGYSSRIVGGN 40 50 60 70 80 90 40 50 60 70 80 pF1KE1 EVIPHSRPYMASLQRNGSHLCGGVLVHPKWVLTAAHCLAQRM--AQLRLVLGLHTL-DSP . . :..:::: .: ::::: .. : :..:::::. . . . . .:: .: :.: NP_115 MSLLSQWPWQASLQFQGYHLCGGSVITPLWIITAAHCVYDLYLPKSWTIQVGLVSLLDNP 100 110 120 130 140 150 90 100 110 120 130 140 pF1KE1 GLTFHIKAAIQHPRYKPVPALENDLALLQLDGKVKPSRTIRPLALPSKRQVVAAGTRCSM . . .. . : .::: : ::.::..: : . .. :.:. ::.... : : NP_115 APSHLVEKIVYHSKYKP-KRLGNDIALMKLAGPLTFNEMIQPVCLPNSEENFPDGKVCWT 160 170 180 190 200 210 150 160 170 180 190 200 pF1KE1 AGWGLTHQG-GRLSRVLRELDLQVLDTRMCNNSRFWNGSLSPSMVCLAADSKDQAPCKGD .::: :..: : : :: . . ......::. ..: .::::.: . . :.:: NP_115 SGWGATEDGAGDASPVLNHAAVPLISNKICNHRDVYGGIISPSMLCAGYLTGGVDSCQGD 220 230 240 250 260 270 210 220 230 240 250 pF1KE1 SGGPLVCGKGRV--LAGVLSFSSRVCTDIFKPPVATAVAPYVSWIRKVTGRSA ::::::: . :. :.:. ::. :... :: : : :. ...::.. NP_115 SGGPLVCQERRLWKLVGATSFGIG-CAEVNKPGVYTRVTSFLDWIHEQMERDLKT 280 290 300 310 320 >>NP_076927 (OMIM: 605511) transmembrane protease serine (454 aa) initn: 462 init1: 160 opt: 529 Z-score: 633.9 bits: 125.7 E(85289): 1.4e-28 Smith-Waterman score: 529; 34.6% identity (65.4% similar) in 257 aa overlap (2-251:192-446) 10 20 30 pF1KE1 MEACVSSLLV-LALGALSVGSSFGTQIIGGR :.:.:. .: : : . .....:.:: NP_076 EGQFREEFVSIDHLLPDDKVTALHHSVYVREGCASGHVVTLQCTACGHRRGYSSRIVGGN 170 180 190 200 210 220 40 50 60 70 80 pF1KE1 EVIPHSRPYMASLQRNGSHLCGGVLVHPKWVLTAAHCLAQRM--AQLRLVLGLHTL-DSP . . :..:::: .: ::::: .. : :..:::::. . . . . .:: .: :.: NP_076 MSLLSQWPWQASLQFQGYHLCGGSVITPLWIITAAHCVYDLYLPKSWTIQVGLVSLLDNP 230 240 250 260 270 280 90 100 110 120 130 140 pF1KE1 GLTFHIKAAIQHPRYKPVPALENDLALLQLDGKVKPSRTIRPLALPSKRQVVAAGTRCSM . . .. . : .::: : ::.::..: : . .. :.:. ::.... : : NP_076 APSHLVEKIVYHSKYKP-KRLGNDIALMKLAGPLTFNEMIQPVCLPNSEENFPDGKVCWT 290 300 310 320 330 340 150 160 170 180 190 200 pF1KE1 AGWGLTHQG-GRLSRVLRELDLQVLDTRMCNNSRFWNGSLSPSMVCLAADSKDQAPCKGD .::: :..: : : :: . . ......::. ..: .::::.: . . :.:: NP_076 SGWGATEDGAGDASPVLNHAAVPLISNKICNHRDVYGGIISPSMLCAGYLTGGVDSCQGD 350 360 370 380 390 400 210 220 230 240 250 pF1KE1 SGGPLVCGKGRV--LAGVLSFSSRVCTDIFKPPVATAVAPYVSWIRKVTGRSA ::::::: . :. :.:. ::. :... :: : : :. ...::.. NP_076 SGGPLVCQERRLWKLVGATSFGIG-CAEVNKPGVYTRVTSFLDWIHEQMERDLKT 410 420 430 440 450 >>NP_219491 (OMIM: 116831) granzyme H isoform 1 prepropr (246 aa) initn: 343 init1: 151 opt: 505 Z-score: 609.2 bits: 120.3 E(85289): 3.4e-27 Smith-Waterman score: 505; 39.1% identity (64.5% similar) in 256 aa overlap (8-255:5-245) 10 20 30 40 50 pF1KE1 MEACVSSLLVLALGALSVGSSFGTQ-IIGGREVIPHSRPYMAS---LQRNGSHLCGGVLV ::.::. :. :. ::. ::::.:. :::::::: ::... . :::.:: NP_219 MQPFLLLLAF-LLTPGA--GTEEIIGGHEAKPHSRPYMAFVQFLQEKSRKRCGGILV 10 20 30 40 50 60 70 80 90 100 110 pF1KE1 HPKWVLTAAHCLAQRMAQLRLVLGLHTLDSPGLT---FHIKAAIQHPRYKPVPALENDLA . .::::::: . ... ..:: :.. : . .: : :: :.: . ::. NP_219 RKDFVLTAAHCQG---SSINVTLGAHNIKEQERTQQFIPVKRPIPHPAYNP-KNFSNDIM 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE1 LLQLDGKVKPSRTIRPLALPSKRQVVAAGTRCSMAGWGLTHQGGRLSRVLRELDLQVLDT ::::. :.: . ..::: :::.. : : ::.:::: . .. :. .:.:. : : NP_219 LLQLERKAKWTTAVRPLRLPSSKAQVKPGQLCSVAGWGYVSMS-TLATTLQEVLLTV--Q 120 130 140 150 160 180 190 200 210 220 230 pF1KE1 RMCNNSRFWNGSLS-PSMVCLAADSKDQAPCKGDSGGPLVCGKGRVLAGVLSFSSRVCTD . :. :...:. : . .:.. .: :. :::::::::: : :.::.... : NP_219 KDCQCERLFHGNYSRATEICVGDPKKTQTGFKGDSGGPLVCKD--VAQGILSYGNKKGTP 170 180 190 200 210 220 240 250 pF1KE1 IFKPPVATAVAPYVSWIRKVTGRSA : : :. .. ::... : NP_219 ---PGVYIKVSHFLPWIKRTMKRL 230 240 257 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 13:37:53 2016 done: Sun Nov 6 13:37:54 2016 Total Scan time: 6.230 Total Display time: 0.000 Function used was FASTA [36.3.4 Apr, 2011]