FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE4221, 767 aa 1>>>pF1KE4221 767 - 767 aa - 767 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.9258+/-0.00037; mu= 7.9822+/- 0.023 mean_var=152.5625+/-31.196, 0's: 0 Z-trim(118.4): 197 B-trim: 435 in 1/56 Lambda= 0.103837 statistics sampled from 30971 (31237) to 30971 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.72), E-opt: 0.2 (0.366), width: 16 Scan time: 13.660 The best scores are: opt bits E(85289) NP_061893 (OMIM: 616637) TBC1 domain family member ( 767) 5254 799.4 0 XP_005257106 (OMIM: 616637) PREDICTED: TBC1 domain ( 767) 5254 799.4 0 XP_006721757 (OMIM: 616637) PREDICTED: TBC1 domain ( 767) 5254 799.4 0 XP_005257107 (OMIM: 616637) PREDICTED: TBC1 domain ( 766) 5235 796.6 0 XP_005257109 (OMIM: 616637) PREDICTED: TBC1 domain ( 640) 4321 659.6 1.1e-188 XP_016879674 (OMIM: 616637) PREDICTED: TBC1 domain ( 639) 4302 656.8 8.2e-188 XP_006721758 (OMIM: 616637) PREDICTED: TBC1 domain ( 634) 3885 594.3 5.2e-169 XP_016879675 (OMIM: 616637) PREDICTED: TBC1 domain ( 599) 3549 544.0 7e-154 XP_016879677 (OMIM: 616637) PREDICTED: TBC1 domain ( 462) 3203 492.1 2.3e-138 XP_011522624 (OMIM: 616637) PREDICTED: TBC1 domain ( 753) 2834 436.9 1.5e-121 XP_011522625 (OMIM: 616637) PREDICTED: TBC1 domain ( 521) 2808 432.9 1.6e-120 XP_016879676 (OMIM: 616637) PREDICTED: TBC1 domain ( 543) 2808 432.9 1.7e-120 NP_001258774 (OMIM: 616637) TBC1 domain family mem ( 405) 2796 431.1 4.6e-120 XP_011522626 (OMIM: 616637) PREDICTED: TBC1 domain ( 396) 2742 423.0 1.2e-117 NP_001258773 (OMIM: 616637) TBC1 domain family mem ( 392) 2331 361.4 4.2e-99 NP_001258775 (OMIM: 616637) TBC1 domain family mem ( 278) 1863 291.2 4e-78 XP_011536984 (OMIM: 612662) PREDICTED: TBC1 domain ( 445) 690 115.6 4.7e-25 XP_006719630 (OMIM: 612662) PREDICTED: TBC1 domain ( 445) 690 115.6 4.7e-25 XP_016875317 (OMIM: 612662) PREDICTED: TBC1 domain ( 530) 690 115.6 5.4e-25 XP_016875316 (OMIM: 612662) PREDICTED: TBC1 domain ( 547) 690 115.6 5.5e-25 XP_016875315 (OMIM: 612662) PREDICTED: TBC1 domain ( 575) 690 115.7 5.7e-25 XP_016875314 (OMIM: 612662) PREDICTED: TBC1 domain ( 575) 690 115.7 5.7e-25 XP_011536981 (OMIM: 612662) PREDICTED: TBC1 domain ( 592) 690 115.7 5.9e-25 XP_016875313 (OMIM: 612662) PREDICTED: TBC1 domain ( 592) 690 115.7 5.9e-25 XP_006719629 (OMIM: 612662) PREDICTED: TBC1 domain ( 592) 690 115.7 5.9e-25 XP_011536982 (OMIM: 612662) PREDICTED: TBC1 domain ( 592) 690 115.7 5.9e-25 NP_001139685 (OMIM: 612662) TBC1 domain family mem ( 674) 690 115.7 6.5e-25 XP_006719628 (OMIM: 612662) PREDICTED: TBC1 domain ( 682) 690 115.7 6.6e-25 NP_001139686 (OMIM: 612662) TBC1 domain family mem ( 682) 690 115.7 6.6e-25 NP_073608 (OMIM: 612662) TBC1 domain family member ( 691) 690 115.7 6.7e-25 NP_001161694 (OMIM: 616659) TBC1 domain family mem ( 615) 689 115.5 6.7e-25 XP_006719627 (OMIM: 612662) PREDICTED: TBC1 domain ( 699) 690 115.7 6.7e-25 NP_078958 (OMIM: 616659) TBC1 domain family member ( 648) 689 115.5 7e-25 NP_002527 (OMIM: 311240) TBC1 domain family member ( 688) 521 90.4 2.8e-17 XP_011525619 (OMIM: 616659) PREDICTED: TBC1 domain ( 501) 449 79.5 3.8e-14 NP_001035037 (OMIM: 611417) small G protein signal (1148) 428 76.6 6.6e-13 NP_001091979 (OMIM: 611418) small G protein signal (1006) 402 72.7 8.8e-12 NP_055668 (OMIM: 611418) small G protein signaling (1051) 402 72.7 9.2e-12 XP_016880963 (OMIM: 611418) PREDICTED: small G pro (1052) 402 72.7 9.2e-12 XP_011522404 (OMIM: 611418) PREDICTED: small G pro (1097) 402 72.7 9.5e-12 XP_016880964 (OMIM: 611418) PREDICTED: small G pro (1047) 397 71.9 1.5e-11 XP_011522405 (OMIM: 611418) PREDICTED: small G pro (1092) 397 71.9 1.6e-11 XP_016880965 (OMIM: 611418) PREDICTED: small G pro ( 785) 361 66.5 5.1e-10 XP_011522410 (OMIM: 611418) PREDICTED: small G pro (1012) 361 66.5 6.3e-10 XP_011522409 (OMIM: 611418) PREDICTED: small G pro (1042) 361 66.5 6.4e-10 XP_011522408 (OMIM: 611418) PREDICTED: small G pro (1057) 361 66.5 6.5e-10 XP_011522407 (OMIM: 611418) PREDICTED: small G pro (1058) 361 66.5 6.5e-10 XP_011522406 (OMIM: 611418) PREDICTED: small G pro (1087) 361 66.5 6.7e-10 XP_011522403 (OMIM: 611418) PREDICTED: small G pro (1103) 361 66.5 6.7e-10 XP_011536983 (OMIM: 612662) PREDICTED: TBC1 domain ( 456) 295 56.4 3.1e-07 >>NP_061893 (OMIM: 616637) TBC1 domain family member 16 (767 aa) initn: 5254 init1: 5254 opt: 5254 Z-score: 4262.4 bits: 799.4 E(85289): 0 Smith-Waterman score: 5254; 100.0% identity (100.0% similar) in 767 aa overlap (1-767:1-767) 10 20 30 40 50 60 pF1KE4 MSLGRLLRRASSKASDLLTLTPGGSGSGSPSVLDGEIIYSKNNVCVHPPEGLQGLGEHHP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 MSLGRLLRRASSKASDLLTLTPGGSGSGSPSVLDGEIIYSKNNVCVHPPEGLQGLGEHHP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 GYLCLYMEKDEMLGATLILAWVPNSRIQRQDEEALRYITPESSPVRKAPRPRGRRTRSSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 GYLCLYMEKDEMLGATLILAWVPNSRIQRQDEEALRYITPESSPVRKAPRPRGRRTRSSG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 ASHQPSPTELRPTLTPKDEDILVVAQSVPDRMLASPAPEDEEKLAQGLGVDGAQPASQPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 ASHQPSPTELRPTLTPKDEDILVVAQSVPDRMLASPAPEDEEKLAQGLGVDGAQPASQPA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 CSPSGILSTVSPQDVTEEGREPRPEAGEEDGSLELSAEGVSRDSSFDSDSDTFSSPFCLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 CSPSGILSTVSPQDVTEEGREPRPEAGEEDGSLELSAEGVSRDSSFDSDSDTFSSPFCLS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 PISAALAESRGSVFLESDSSPPSSSDAGLRFPDSNGLLQTPRWDEPQRVCALEQICGVFR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 PISAALAESRGSVFLESDSSPPSSSDAGLRFPDSNGLLQTPRWDEPQRVCALEQICGVFR 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 VDLGHMRSLRLFFSDEACTSGQLVVASRESQYKVFHFHHGGLDKLSDVFQQWKYCTEMQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 VDLGHMRSLRLFFSDEACTSGQLVVASRESQYKVFHFHHGGLDKLSDVFQQWKYCTEMQL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 KDQQVAPDKTCMQFSIRRPKLPSSETHPEESMYKRLGVSAWLNHLNELGQVEEEYKLRKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 KDQQVAPDKTCMQFSIRRPKLPSSETHPEESMYKRLGVSAWLNHLNELGQVEEEYKLRKA 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE4 IFFGGIDVSIRGEVWPFLLRYYSHESTSEEREALRLQKRKEYSEIQQKRLSMTPEEHRAF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 IFFGGIDVSIRGEVWPFLLRYYSHESTSEEREALRLQKRKEYSEIQQKRLSMTPEEHRAF 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE4 WRNVQFTVDKDVVRTDRNNQFFRGEDNPNVESMRRILLNYAVYNPAVGYSQGMSDLVAPI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 WRNVQFTVDKDVVRTDRNNQFFRGEDNPNVESMRRILLNYAVYNPAVGYSQGMSDLVAPI 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE4 LAEVLDESDTFWCFVGLMQNTIFVSSPRDEDMEKQLLYLRELLRLTHVRFYQHLVSLGED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 LAEVLDESDTFWCFVGLMQNTIFVSSPRDEDMEKQLLYLRELLRLTHVRFYQHLVSLGED 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE4 GLQMLFCHRWLLLCFKREFPEAEALRIWEACWAHYQTDYFHLFICVAIVAIYGDDVIEQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 GLQMLFCHRWLLLCFKREFPEAEALRIWEACWAHYQTDYFHLFICVAIVAIYGDDVIEQQ 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE4 LATDQMLLHFGNLAMHMNGELVLRKARSLLYQFRLLPRIPCSLHDLCKLCGSGMWDSGSM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 LATDQMLLHFGNLAMHMNGELVLRKARSLLYQFRLLPRIPCSLHDLCKLCGSGMWDSGSM 670 680 690 700 710 720 730 740 750 760 pF1KE4 PAVECTGHHPGSESCPYGGTVEMPSPKSLREGKKGPKTPQDGFGFRR ::::::::::::::::::::::::::::::::::::::::::::::: NP_061 PAVECTGHHPGSESCPYGGTVEMPSPKSLREGKKGPKTPQDGFGFRR 730 740 750 760 >>XP_005257106 (OMIM: 616637) PREDICTED: TBC1 domain fam (767 aa) initn: 5254 init1: 5254 opt: 5254 Z-score: 4262.4 bits: 799.4 E(85289): 0 Smith-Waterman score: 5254; 100.0% identity (100.0% similar) in 767 aa overlap (1-767:1-767) 10 20 30 40 50 60 pF1KE4 MSLGRLLRRASSKASDLLTLTPGGSGSGSPSVLDGEIIYSKNNVCVHPPEGLQGLGEHHP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MSLGRLLRRASSKASDLLTLTPGGSGSGSPSVLDGEIIYSKNNVCVHPPEGLQGLGEHHP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 GYLCLYMEKDEMLGATLILAWVPNSRIQRQDEEALRYITPESSPVRKAPRPRGRRTRSSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GYLCLYMEKDEMLGATLILAWVPNSRIQRQDEEALRYITPESSPVRKAPRPRGRRTRSSG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 ASHQPSPTELRPTLTPKDEDILVVAQSVPDRMLASPAPEDEEKLAQGLGVDGAQPASQPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ASHQPSPTELRPTLTPKDEDILVVAQSVPDRMLASPAPEDEEKLAQGLGVDGAQPASQPA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 CSPSGILSTVSPQDVTEEGREPRPEAGEEDGSLELSAEGVSRDSSFDSDSDTFSSPFCLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 CSPSGILSTVSPQDVTEEGREPRPEAGEEDGSLELSAEGVSRDSSFDSDSDTFSSPFCLS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 PISAALAESRGSVFLESDSSPPSSSDAGLRFPDSNGLLQTPRWDEPQRVCALEQICGVFR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PISAALAESRGSVFLESDSSPPSSSDAGLRFPDSNGLLQTPRWDEPQRVCALEQICGVFR 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 VDLGHMRSLRLFFSDEACTSGQLVVASRESQYKVFHFHHGGLDKLSDVFQQWKYCTEMQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VDLGHMRSLRLFFSDEACTSGQLVVASRESQYKVFHFHHGGLDKLSDVFQQWKYCTEMQL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 KDQQVAPDKTCMQFSIRRPKLPSSETHPEESMYKRLGVSAWLNHLNELGQVEEEYKLRKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KDQQVAPDKTCMQFSIRRPKLPSSETHPEESMYKRLGVSAWLNHLNELGQVEEEYKLRKA 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE4 IFFGGIDVSIRGEVWPFLLRYYSHESTSEEREALRLQKRKEYSEIQQKRLSMTPEEHRAF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 IFFGGIDVSIRGEVWPFLLRYYSHESTSEEREALRLQKRKEYSEIQQKRLSMTPEEHRAF 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE4 WRNVQFTVDKDVVRTDRNNQFFRGEDNPNVESMRRILLNYAVYNPAVGYSQGMSDLVAPI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 WRNVQFTVDKDVVRTDRNNQFFRGEDNPNVESMRRILLNYAVYNPAVGYSQGMSDLVAPI 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE4 LAEVLDESDTFWCFVGLMQNTIFVSSPRDEDMEKQLLYLRELLRLTHVRFYQHLVSLGED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LAEVLDESDTFWCFVGLMQNTIFVSSPRDEDMEKQLLYLRELLRLTHVRFYQHLVSLGED 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE4 GLQMLFCHRWLLLCFKREFPEAEALRIWEACWAHYQTDYFHLFICVAIVAIYGDDVIEQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GLQMLFCHRWLLLCFKREFPEAEALRIWEACWAHYQTDYFHLFICVAIVAIYGDDVIEQQ 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE4 LATDQMLLHFGNLAMHMNGELVLRKARSLLYQFRLLPRIPCSLHDLCKLCGSGMWDSGSM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LATDQMLLHFGNLAMHMNGELVLRKARSLLYQFRLLPRIPCSLHDLCKLCGSGMWDSGSM 670 680 690 700 710 720 730 740 750 760 pF1KE4 PAVECTGHHPGSESCPYGGTVEMPSPKSLREGKKGPKTPQDGFGFRR ::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PAVECTGHHPGSESCPYGGTVEMPSPKSLREGKKGPKTPQDGFGFRR 730 740 750 760 >>XP_006721757 (OMIM: 616637) PREDICTED: TBC1 domain fam (767 aa) initn: 5254 init1: 5254 opt: 5254 Z-score: 4262.4 bits: 799.4 E(85289): 0 Smith-Waterman score: 5254; 100.0% identity (100.0% similar) in 767 aa overlap (1-767:1-767) 10 20 30 40 50 60 pF1KE4 MSLGRLLRRASSKASDLLTLTPGGSGSGSPSVLDGEIIYSKNNVCVHPPEGLQGLGEHHP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MSLGRLLRRASSKASDLLTLTPGGSGSGSPSVLDGEIIYSKNNVCVHPPEGLQGLGEHHP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 GYLCLYMEKDEMLGATLILAWVPNSRIQRQDEEALRYITPESSPVRKAPRPRGRRTRSSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GYLCLYMEKDEMLGATLILAWVPNSRIQRQDEEALRYITPESSPVRKAPRPRGRRTRSSG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 ASHQPSPTELRPTLTPKDEDILVVAQSVPDRMLASPAPEDEEKLAQGLGVDGAQPASQPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ASHQPSPTELRPTLTPKDEDILVVAQSVPDRMLASPAPEDEEKLAQGLGVDGAQPASQPA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 CSPSGILSTVSPQDVTEEGREPRPEAGEEDGSLELSAEGVSRDSSFDSDSDTFSSPFCLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 CSPSGILSTVSPQDVTEEGREPRPEAGEEDGSLELSAEGVSRDSSFDSDSDTFSSPFCLS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 PISAALAESRGSVFLESDSSPPSSSDAGLRFPDSNGLLQTPRWDEPQRVCALEQICGVFR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 PISAALAESRGSVFLESDSSPPSSSDAGLRFPDSNGLLQTPRWDEPQRVCALEQICGVFR 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 VDLGHMRSLRLFFSDEACTSGQLVVASRESQYKVFHFHHGGLDKLSDVFQQWKYCTEMQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 VDLGHMRSLRLFFSDEACTSGQLVVASRESQYKVFHFHHGGLDKLSDVFQQWKYCTEMQL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 KDQQVAPDKTCMQFSIRRPKLPSSETHPEESMYKRLGVSAWLNHLNELGQVEEEYKLRKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 KDQQVAPDKTCMQFSIRRPKLPSSETHPEESMYKRLGVSAWLNHLNELGQVEEEYKLRKA 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE4 IFFGGIDVSIRGEVWPFLLRYYSHESTSEEREALRLQKRKEYSEIQQKRLSMTPEEHRAF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 IFFGGIDVSIRGEVWPFLLRYYSHESTSEEREALRLQKRKEYSEIQQKRLSMTPEEHRAF 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE4 WRNVQFTVDKDVVRTDRNNQFFRGEDNPNVESMRRILLNYAVYNPAVGYSQGMSDLVAPI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 WRNVQFTVDKDVVRTDRNNQFFRGEDNPNVESMRRILLNYAVYNPAVGYSQGMSDLVAPI 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE4 LAEVLDESDTFWCFVGLMQNTIFVSSPRDEDMEKQLLYLRELLRLTHVRFYQHLVSLGED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LAEVLDESDTFWCFVGLMQNTIFVSSPRDEDMEKQLLYLRELLRLTHVRFYQHLVSLGED 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE4 GLQMLFCHRWLLLCFKREFPEAEALRIWEACWAHYQTDYFHLFICVAIVAIYGDDVIEQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GLQMLFCHRWLLLCFKREFPEAEALRIWEACWAHYQTDYFHLFICVAIVAIYGDDVIEQQ 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE4 LATDQMLLHFGNLAMHMNGELVLRKARSLLYQFRLLPRIPCSLHDLCKLCGSGMWDSGSM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LATDQMLLHFGNLAMHMNGELVLRKARSLLYQFRLLPRIPCSLHDLCKLCGSGMWDSGSM 670 680 690 700 710 720 730 740 750 760 pF1KE4 PAVECTGHHPGSESCPYGGTVEMPSPKSLREGKKGPKTPQDGFGFRR ::::::::::::::::::::::::::::::::::::::::::::::: XP_006 PAVECTGHHPGSESCPYGGTVEMPSPKSLREGKKGPKTPQDGFGFRR 730 740 750 760 >>XP_005257107 (OMIM: 616637) PREDICTED: TBC1 domain fam (766 aa) initn: 2801 init1: 2801 opt: 5235 Z-score: 4247.1 bits: 796.6 E(85289): 0 Smith-Waterman score: 5235; 99.9% identity (99.9% similar) in 767 aa overlap (1-767:1-766) 10 20 30 40 50 60 pF1KE4 MSLGRLLRRASSKASDLLTLTPGGSGSGSPSVLDGEIIYSKNNVCVHPPEGLQGLGEHHP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MSLGRLLRRASSKASDLLTLTPGGSGSGSPSVLDGEIIYSKNNVCVHPPEGLQGLGEHHP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 GYLCLYMEKDEMLGATLILAWVPNSRIQRQDEEALRYITPESSPVRKAPRPRGRRTRSSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GYLCLYMEKDEMLGATLILAWVPNSRIQRQDEEALRYITPESSPVRKAPRPRGRRTRSSG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 ASHQPSPTELRPTLTPKDEDILVVAQSVPDRMLASPAPEDEEKLAQGLGVDGAQPASQPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ASHQPSPTELRPTLTPKDEDILVVAQSVPDRMLASPAPEDEEKLAQGLGVDGAQPASQPA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 CSPSGILSTVSPQDVTEEGREPRPEAGEEDGSLELSAEGVSRDSSFDSDSDTFSSPFCLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 CSPSGILSTVSPQDVTEEGREPRPEAGEEDGSLELSAEGVSRDSSFDSDSDTFSSPFCLS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 PISAALAESRGSVFLESDSSPPSSSDAGLRFPDSNGLLQTPRWDEPQRVCALEQICGVFR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PISAALAESRGSVFLESDSSPPSSSDAGLRFPDSNGLLQTPRWDEPQRVCALEQICGVFR 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 VDLGHMRSLRLFFSDEACTSGQLVVASRESQYKVFHFHHGGLDKLSDVFQQWKYCTEMQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VDLGHMRSLRLFFSDEACTSGQLVVASRESQYKVFHFHHGGLDKLSDVFQQWKYCTEMQL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 KDQQVAPDKTCMQFSIRRPKLPSSETHPEESMYKRLGVSAWLNHLNELGQVEEEYKLRKA ::: :::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KDQ-VAPDKTCMQFSIRRPKLPSSETHPEESMYKRLGVSAWLNHLNELGQVEEEYKLRKA 370 380 390 400 410 430 440 450 460 470 480 pF1KE4 IFFGGIDVSIRGEVWPFLLRYYSHESTSEEREALRLQKRKEYSEIQQKRLSMTPEEHRAF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 IFFGGIDVSIRGEVWPFLLRYYSHESTSEEREALRLQKRKEYSEIQQKRLSMTPEEHRAF 420 430 440 450 460 470 490 500 510 520 530 540 pF1KE4 WRNVQFTVDKDVVRTDRNNQFFRGEDNPNVESMRRILLNYAVYNPAVGYSQGMSDLVAPI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 WRNVQFTVDKDVVRTDRNNQFFRGEDNPNVESMRRILLNYAVYNPAVGYSQGMSDLVAPI 480 490 500 510 520 530 550 560 570 580 590 600 pF1KE4 LAEVLDESDTFWCFVGLMQNTIFVSSPRDEDMEKQLLYLRELLRLTHVRFYQHLVSLGED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LAEVLDESDTFWCFVGLMQNTIFVSSPRDEDMEKQLLYLRELLRLTHVRFYQHLVSLGED 540 550 560 570 580 590 610 620 630 640 650 660 pF1KE4 GLQMLFCHRWLLLCFKREFPEAEALRIWEACWAHYQTDYFHLFICVAIVAIYGDDVIEQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GLQMLFCHRWLLLCFKREFPEAEALRIWEACWAHYQTDYFHLFICVAIVAIYGDDVIEQQ 600 610 620 630 640 650 670 680 690 700 710 720 pF1KE4 LATDQMLLHFGNLAMHMNGELVLRKARSLLYQFRLLPRIPCSLHDLCKLCGSGMWDSGSM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LATDQMLLHFGNLAMHMNGELVLRKARSLLYQFRLLPRIPCSLHDLCKLCGSGMWDSGSM 660 670 680 690 700 710 730 740 750 760 pF1KE4 PAVECTGHHPGSESCPYGGTVEMPSPKSLREGKKGPKTPQDGFGFRR ::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PAVECTGHHPGSESCPYGGTVEMPSPKSLREGKKGPKTPQDGFGFRR 720 730 740 750 760 >>XP_005257109 (OMIM: 616637) PREDICTED: TBC1 domain fam (640 aa) initn: 4321 init1: 4321 opt: 4321 Z-score: 3508.2 bits: 659.6 E(85289): 1.1e-188 Smith-Waterman score: 4321; 100.0% identity (100.0% similar) in 636 aa overlap (1-636:1-636) 10 20 30 40 50 60 pF1KE4 MSLGRLLRRASSKASDLLTLTPGGSGSGSPSVLDGEIIYSKNNVCVHPPEGLQGLGEHHP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MSLGRLLRRASSKASDLLTLTPGGSGSGSPSVLDGEIIYSKNNVCVHPPEGLQGLGEHHP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 GYLCLYMEKDEMLGATLILAWVPNSRIQRQDEEALRYITPESSPVRKAPRPRGRRTRSSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GYLCLYMEKDEMLGATLILAWVPNSRIQRQDEEALRYITPESSPVRKAPRPRGRRTRSSG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 ASHQPSPTELRPTLTPKDEDILVVAQSVPDRMLASPAPEDEEKLAQGLGVDGAQPASQPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ASHQPSPTELRPTLTPKDEDILVVAQSVPDRMLASPAPEDEEKLAQGLGVDGAQPASQPA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 CSPSGILSTVSPQDVTEEGREPRPEAGEEDGSLELSAEGVSRDSSFDSDSDTFSSPFCLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 CSPSGILSTVSPQDVTEEGREPRPEAGEEDGSLELSAEGVSRDSSFDSDSDTFSSPFCLS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 PISAALAESRGSVFLESDSSPPSSSDAGLRFPDSNGLLQTPRWDEPQRVCALEQICGVFR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PISAALAESRGSVFLESDSSPPSSSDAGLRFPDSNGLLQTPRWDEPQRVCALEQICGVFR 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 VDLGHMRSLRLFFSDEACTSGQLVVASRESQYKVFHFHHGGLDKLSDVFQQWKYCTEMQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VDLGHMRSLRLFFSDEACTSGQLVVASRESQYKVFHFHHGGLDKLSDVFQQWKYCTEMQL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 KDQQVAPDKTCMQFSIRRPKLPSSETHPEESMYKRLGVSAWLNHLNELGQVEEEYKLRKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KDQQVAPDKTCMQFSIRRPKLPSSETHPEESMYKRLGVSAWLNHLNELGQVEEEYKLRKA 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE4 IFFGGIDVSIRGEVWPFLLRYYSHESTSEEREALRLQKRKEYSEIQQKRLSMTPEEHRAF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 IFFGGIDVSIRGEVWPFLLRYYSHESTSEEREALRLQKRKEYSEIQQKRLSMTPEEHRAF 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE4 WRNVQFTVDKDVVRTDRNNQFFRGEDNPNVESMRRILLNYAVYNPAVGYSQGMSDLVAPI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 WRNVQFTVDKDVVRTDRNNQFFRGEDNPNVESMRRILLNYAVYNPAVGYSQGMSDLVAPI 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE4 LAEVLDESDTFWCFVGLMQNTIFVSSPRDEDMEKQLLYLRELLRLTHVRFYQHLVSLGED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LAEVLDESDTFWCFVGLMQNTIFVSSPRDEDMEKQLLYLRELLRLTHVRFYQHLVSLGED 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE4 GLQMLFCHRWLLLCFKREFPEAEALRIWEACWAHYQTDYFHLFICVAIVAIYGDDVIEQQ :::::::::::::::::::::::::::::::::::: XP_005 GLQMLFCHRWLLLCFKREFPEAEALRIWEACWAHYQGADV 610 620 630 640 670 680 690 700 710 720 pF1KE4 LATDQMLLHFGNLAMHMNGELVLRKARSLLYQFRLLPRIPCSLHDLCKLCGSGMWDSGSM >>XP_016879674 (OMIM: 616637) PREDICTED: TBC1 domain fam (639 aa) initn: 2453 init1: 2453 opt: 4302 Z-score: 3492.9 bits: 656.8 E(85289): 8.2e-188 Smith-Waterman score: 4302; 99.8% identity (99.8% similar) in 636 aa overlap (1-636:1-635) 10 20 30 40 50 60 pF1KE4 MSLGRLLRRASSKASDLLTLTPGGSGSGSPSVLDGEIIYSKNNVCVHPPEGLQGLGEHHP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MSLGRLLRRASSKASDLLTLTPGGSGSGSPSVLDGEIIYSKNNVCVHPPEGLQGLGEHHP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 GYLCLYMEKDEMLGATLILAWVPNSRIQRQDEEALRYITPESSPVRKAPRPRGRRTRSSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GYLCLYMEKDEMLGATLILAWVPNSRIQRQDEEALRYITPESSPVRKAPRPRGRRTRSSG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 ASHQPSPTELRPTLTPKDEDILVVAQSVPDRMLASPAPEDEEKLAQGLGVDGAQPASQPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ASHQPSPTELRPTLTPKDEDILVVAQSVPDRMLASPAPEDEEKLAQGLGVDGAQPASQPA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 CSPSGILSTVSPQDVTEEGREPRPEAGEEDGSLELSAEGVSRDSSFDSDSDTFSSPFCLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CSPSGILSTVSPQDVTEEGREPRPEAGEEDGSLELSAEGVSRDSSFDSDSDTFSSPFCLS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 PISAALAESRGSVFLESDSSPPSSSDAGLRFPDSNGLLQTPRWDEPQRVCALEQICGVFR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PISAALAESRGSVFLESDSSPPSSSDAGLRFPDSNGLLQTPRWDEPQRVCALEQICGVFR 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 VDLGHMRSLRLFFSDEACTSGQLVVASRESQYKVFHFHHGGLDKLSDVFQQWKYCTEMQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VDLGHMRSLRLFFSDEACTSGQLVVASRESQYKVFHFHHGGLDKLSDVFQQWKYCTEMQL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 KDQQVAPDKTCMQFSIRRPKLPSSETHPEESMYKRLGVSAWLNHLNELGQVEEEYKLRKA ::: :::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KDQ-VAPDKTCMQFSIRRPKLPSSETHPEESMYKRLGVSAWLNHLNELGQVEEEYKLRKA 370 380 390 400 410 430 440 450 460 470 480 pF1KE4 IFFGGIDVSIRGEVWPFLLRYYSHESTSEEREALRLQKRKEYSEIQQKRLSMTPEEHRAF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IFFGGIDVSIRGEVWPFLLRYYSHESTSEEREALRLQKRKEYSEIQQKRLSMTPEEHRAF 420 430 440 450 460 470 490 500 510 520 530 540 pF1KE4 WRNVQFTVDKDVVRTDRNNQFFRGEDNPNVESMRRILLNYAVYNPAVGYSQGMSDLVAPI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 WRNVQFTVDKDVVRTDRNNQFFRGEDNPNVESMRRILLNYAVYNPAVGYSQGMSDLVAPI 480 490 500 510 520 530 550 560 570 580 590 600 pF1KE4 LAEVLDESDTFWCFVGLMQNTIFVSSPRDEDMEKQLLYLRELLRLTHVRFYQHLVSLGED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LAEVLDESDTFWCFVGLMQNTIFVSSPRDEDMEKQLLYLRELLRLTHVRFYQHLVSLGED 540 550 560 570 580 590 610 620 630 640 650 660 pF1KE4 GLQMLFCHRWLLLCFKREFPEAEALRIWEACWAHYQTDYFHLFICVAIVAIYGDDVIEQQ :::::::::::::::::::::::::::::::::::: XP_016 GLQMLFCHRWLLLCFKREFPEAEALRIWEACWAHYQGADV 600 610 620 630 670 680 690 700 710 720 pF1KE4 LATDQMLLHFGNLAMHMNGELVLRKARSLLYQFRLLPRIPCSLHDLCKLCGSGMWDSGSM >>XP_006721758 (OMIM: 616637) PREDICTED: TBC1 domain fam (634 aa) initn: 3885 init1: 3885 opt: 3885 Z-score: 3155.3 bits: 594.3 E(85289): 5.2e-169 Smith-Waterman score: 3885; 100.0% identity (100.0% similar) in 576 aa overlap (1-576:1-576) 10 20 30 40 50 60 pF1KE4 MSLGRLLRRASSKASDLLTLTPGGSGSGSPSVLDGEIIYSKNNVCVHPPEGLQGLGEHHP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MSLGRLLRRASSKASDLLTLTPGGSGSGSPSVLDGEIIYSKNNVCVHPPEGLQGLGEHHP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 GYLCLYMEKDEMLGATLILAWVPNSRIQRQDEEALRYITPESSPVRKAPRPRGRRTRSSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GYLCLYMEKDEMLGATLILAWVPNSRIQRQDEEALRYITPESSPVRKAPRPRGRRTRSSG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 ASHQPSPTELRPTLTPKDEDILVVAQSVPDRMLASPAPEDEEKLAQGLGVDGAQPASQPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ASHQPSPTELRPTLTPKDEDILVVAQSVPDRMLASPAPEDEEKLAQGLGVDGAQPASQPA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 CSPSGILSTVSPQDVTEEGREPRPEAGEEDGSLELSAEGVSRDSSFDSDSDTFSSPFCLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 CSPSGILSTVSPQDVTEEGREPRPEAGEEDGSLELSAEGVSRDSSFDSDSDTFSSPFCLS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 PISAALAESRGSVFLESDSSPPSSSDAGLRFPDSNGLLQTPRWDEPQRVCALEQICGVFR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 PISAALAESRGSVFLESDSSPPSSSDAGLRFPDSNGLLQTPRWDEPQRVCALEQICGVFR 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 VDLGHMRSLRLFFSDEACTSGQLVVASRESQYKVFHFHHGGLDKLSDVFQQWKYCTEMQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 VDLGHMRSLRLFFSDEACTSGQLVVASRESQYKVFHFHHGGLDKLSDVFQQWKYCTEMQL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 KDQQVAPDKTCMQFSIRRPKLPSSETHPEESMYKRLGVSAWLNHLNELGQVEEEYKLRKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 KDQQVAPDKTCMQFSIRRPKLPSSETHPEESMYKRLGVSAWLNHLNELGQVEEEYKLRKA 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE4 IFFGGIDVSIRGEVWPFLLRYYSHESTSEEREALRLQKRKEYSEIQQKRLSMTPEEHRAF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 IFFGGIDVSIRGEVWPFLLRYYSHESTSEEREALRLQKRKEYSEIQQKRLSMTPEEHRAF 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE4 WRNVQFTVDKDVVRTDRNNQFFRGEDNPNVESMRRILLNYAVYNPAVGYSQGMSDLVAPI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 WRNVQFTVDKDVVRTDRNNQFFRGEDNPNVESMRRILLNYAVYNPAVGYSQGMSDLVAPI 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE4 LAEVLDESDTFWCFVGLMQNTIFVSSPRDEDMEKQLLYLRELLRLTHVRFYQHLVSLGED :::::::::::::::::::::::::::::::::::: XP_006 LAEVLDESDTFWCFVGLMQNTIFVSSPRDEDMEKQLEEWTWETAPKCALRVGSLPGHGAA 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE4 GLQMLFCHRWLLLCFKREFPEAEALRIWEACWAHYQTDYFHLFICVAIVAIYGDDVIEQQ XP_006 ASVLPRPGTTLCLTLDHTTASGTVRSGRNWQRQV 610 620 630 >>XP_016879675 (OMIM: 616637) PREDICTED: TBC1 domain fam (599 aa) initn: 3549 init1: 3549 opt: 3549 Z-score: 2883.6 bits: 544.0 E(85289): 7e-154 Smith-Waterman score: 3549; 98.8% identity (99.2% similar) in 518 aa overlap (250-767:82-599) 220 230 240 250 260 270 pF1KE4 VSRDSSFDSDSDTFSSPFCLSPISAALAESRGSVFLESDSSPPSSSDAGLRFPDSNGLLQ ::: .. ::::::::::::::::::::: XP_016 GLHGQMPLVTFCSLVPKMRCRLCRESRLSPRGSGAERAVSSPPSSSDAGLRFPDSNGLLQ 60 70 80 90 100 110 280 290 300 310 320 330 pF1KE4 TPRWDEPQRVCALEQICGVFRVDLGHMRSLRLFFSDEACTSGQLVVASRESQYKVFHFHH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TPRWDEPQRVCALEQICGVFRVDLGHMRSLRLFFSDEACTSGQLVVASRESQYKVFHFHH 120 130 140 150 160 170 340 350 360 370 380 390 pF1KE4 GGLDKLSDVFQQWKYCTEMQLKDQQVAPDKTCMQFSIRRPKLPSSETHPEESMYKRLGVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GGLDKLSDVFQQWKYCTEMQLKDQQVAPDKTCMQFSIRRPKLPSSETHPEESMYKRLGVS 180 190 200 210 220 230 400 410 420 430 440 450 pF1KE4 AWLNHLNELGQVEEEYKLRKAIFFGGIDVSIRGEVWPFLLRYYSHESTSEEREALRLQKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AWLNHLNELGQVEEEYKLRKAIFFGGIDVSIRGEVWPFLLRYYSHESTSEEREALRLQKR 240 250 260 270 280 290 460 470 480 490 500 510 pF1KE4 KEYSEIQQKRLSMTPEEHRAFWRNVQFTVDKDVVRTDRNNQFFRGEDNPNVESMRRILLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KEYSEIQQKRLSMTPEEHRAFWRNVQFTVDKDVVRTDRNNQFFRGEDNPNVESMRRILLN 300 310 320 330 340 350 520 530 540 550 560 570 pF1KE4 YAVYNPAVGYSQGMSDLVAPILAEVLDESDTFWCFVGLMQNTIFVSSPRDEDMEKQLLYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YAVYNPAVGYSQGMSDLVAPILAEVLDESDTFWCFVGLMQNTIFVSSPRDEDMEKQLLYL 360 370 380 390 400 410 580 590 600 610 620 630 pF1KE4 RELLRLTHVRFYQHLVSLGEDGLQMLFCHRWLLLCFKREFPEAEALRIWEACWAHYQTDY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RELLRLTHVRFYQHLVSLGEDGLQMLFCHRWLLLCFKREFPEAEALRIWEACWAHYQTDY 420 430 440 450 460 470 640 650 660 670 680 690 pF1KE4 FHLFICVAIVAIYGDDVIEQQLATDQMLLHFGNLAMHMNGELVLRKARSLLYQFRLLPRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FHLFICVAIVAIYGDDVIEQQLATDQMLLHFGNLAMHMNGELVLRKARSLLYQFRLLPRI 480 490 500 510 520 530 700 710 720 730 740 750 pF1KE4 PCSLHDLCKLCGSGMWDSGSMPAVECTGHHPGSESCPYGGTVEMPSPKSLREGKKGPKTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PCSLHDLCKLCGSGMWDSGSMPAVECTGHHPGSESCPYGGTVEMPSPKSLREGKKGPKTP 540 550 560 570 580 590 760 pF1KE4 QDGFGFRR :::::::: XP_016 QDGFGFRR >>XP_016879677 (OMIM: 616637) PREDICTED: TBC1 domain fam (462 aa) initn: 3203 init1: 3203 opt: 3203 Z-score: 2605.2 bits: 492.1 E(85289): 2.3e-138 Smith-Waterman score: 3203; 100.0% identity (100.0% similar) in 462 aa overlap (306-767:1-462) 280 290 300 310 320 330 pF1KE4 GLLQTPRWDEPQRVCALEQICGVFRVDLGHMRSLRLFFSDEACTSGQLVVASRESQYKVF :::::::::::::::::::::::::::::: XP_016 MRSLRLFFSDEACTSGQLVVASRESQYKVF 10 20 30 340 350 360 370 380 390 pF1KE4 HFHHGGLDKLSDVFQQWKYCTEMQLKDQQVAPDKTCMQFSIRRPKLPSSETHPEESMYKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HFHHGGLDKLSDVFQQWKYCTEMQLKDQQVAPDKTCMQFSIRRPKLPSSETHPEESMYKR 40 50 60 70 80 90 400 410 420 430 440 450 pF1KE4 LGVSAWLNHLNELGQVEEEYKLRKAIFFGGIDVSIRGEVWPFLLRYYSHESTSEEREALR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LGVSAWLNHLNELGQVEEEYKLRKAIFFGGIDVSIRGEVWPFLLRYYSHESTSEEREALR 100 110 120 130 140 150 460 470 480 490 500 510 pF1KE4 LQKRKEYSEIQQKRLSMTPEEHRAFWRNVQFTVDKDVVRTDRNNQFFRGEDNPNVESMRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LQKRKEYSEIQQKRLSMTPEEHRAFWRNVQFTVDKDVVRTDRNNQFFRGEDNPNVESMRR 160 170 180 190 200 210 520 530 540 550 560 570 pF1KE4 ILLNYAVYNPAVGYSQGMSDLVAPILAEVLDESDTFWCFVGLMQNTIFVSSPRDEDMEKQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ILLNYAVYNPAVGYSQGMSDLVAPILAEVLDESDTFWCFVGLMQNTIFVSSPRDEDMEKQ 220 230 240 250 260 270 580 590 600 610 620 630 pF1KE4 LLYLRELLRLTHVRFYQHLVSLGEDGLQMLFCHRWLLLCFKREFPEAEALRIWEACWAHY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LLYLRELLRLTHVRFYQHLVSLGEDGLQMLFCHRWLLLCFKREFPEAEALRIWEACWAHY 280 290 300 310 320 330 640 650 660 670 680 690 pF1KE4 QTDYFHLFICVAIVAIYGDDVIEQQLATDQMLLHFGNLAMHMNGELVLRKARSLLYQFRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QTDYFHLFICVAIVAIYGDDVIEQQLATDQMLLHFGNLAMHMNGELVLRKARSLLYQFRL 340 350 360 370 380 390 700 710 720 730 740 750 pF1KE4 LPRIPCSLHDLCKLCGSGMWDSGSMPAVECTGHHPGSESCPYGGTVEMPSPKSLREGKKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LPRIPCSLHDLCKLCGSGMWDSGSMPAVECTGHHPGSESCPYGGTVEMPSPKSLREGKKG 400 410 420 430 440 450 760 pF1KE4 PKTPQDGFGFRR :::::::::::: XP_016 PKTPQDGFGFRR 460 >>XP_011522624 (OMIM: 616637) PREDICTED: TBC1 domain fam (753 aa) initn: 2834 init1: 2834 opt: 2834 Z-score: 2303.3 bits: 436.9 E(85289): 1.5e-121 Smith-Waterman score: 5125; 98.2% identity (98.2% similar) in 767 aa overlap (1-767:1-753) 10 20 30 40 50 60 pF1KE4 MSLGRLLRRASSKASDLLTLTPGGSGSGSPSVLDGEIIYSKNNVCVHPPEGLQGLGEHHP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MSLGRLLRRASSKASDLLTLTPGGSGSGSPSVLDGEIIYSKNNVCVHPPEGLQGLGEHHP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 GYLCLYMEKDEMLGATLILAWVPNSRIQRQDEEALRYITPESSPVRKAPRPRGRRTRSSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GYLCLYMEKDEMLGATLILAWVPNSRIQRQDEEALRYITPESSPVRKAPRPRGRRTRSSG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 ASHQPSPTELRPTLTPKDEDILVVAQSVPDRMLASPAPEDEEKLAQGLGVDGAQPASQPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ASHQPSPTELRPTLTPKDEDILVVAQSVPDRMLASPAPEDEEKLAQGLGVDGAQPASQPA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 CSPSGILSTVSPQDVTEEGREPRPEAGEEDGSLELSAEGVSRDSSFDSDSDTFSSPFCLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CSPSGILSTVSPQDVTEEGREPRPEAGEEDGSLELSAEGVSRDSSFDSDSDTFSSPFCLS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 PISAALAESRGSVFLESDSSPPSSSDAGLRFPDSNGLLQTPRWDEPQRVCALEQICGVFR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PISAALAESRGSVFLESDSSPPSSSDAGLRFPDSNGLLQTPRWDEPQRVCALEQICGVFR 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 VDLGHMRSLRLFFSDEACTSGQLVVASRESQYKVFHFHHGGLDKLSDVFQQWKYCTEMQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VDLGHMRSLRLFFSDEACTSGQLVVASRESQYKVFHFHHGGLDKLSDVFQQWKYCTEMQL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 KDQQVAPDKTCMQFSIRRPKLPSSETHPEESMYKRLGVSAWLNHLNELGQVEEEYKLRKA ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KDQQVAPDKTCMQFSIRRPKLPSSETHPEESMYKRLGVSAWLNHLNELGQVEEEYKLRK- 370 380 390 400 410 430 440 450 460 470 480 pF1KE4 IFFGGIDVSIRGEVWPFLLRYYSHESTSEEREALRLQKRKEYSEIQQKRLSMTPEEHRAF ::::::::::::::::::::::::::::::::::::::::::::::: XP_011 -------------VWPFLLRYYSHESTSEEREALRLQKRKEYSEIQQKRLSMTPEEHRAF 420 430 440 450 460 490 500 510 520 530 540 pF1KE4 WRNVQFTVDKDVVRTDRNNQFFRGEDNPNVESMRRILLNYAVYNPAVGYSQGMSDLVAPI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 WRNVQFTVDKDVVRTDRNNQFFRGEDNPNVESMRRILLNYAVYNPAVGYSQGMSDLVAPI 470 480 490 500 510 520 550 560 570 580 590 600 pF1KE4 LAEVLDESDTFWCFVGLMQNTIFVSSPRDEDMEKQLLYLRELLRLTHVRFYQHLVSLGED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LAEVLDESDTFWCFVGLMQNTIFVSSPRDEDMEKQLLYLRELLRLTHVRFYQHLVSLGED 530 540 550 560 570 580 610 620 630 640 650 660 pF1KE4 GLQMLFCHRWLLLCFKREFPEAEALRIWEACWAHYQTDYFHLFICVAIVAIYGDDVIEQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GLQMLFCHRWLLLCFKREFPEAEALRIWEACWAHYQTDYFHLFICVAIVAIYGDDVIEQQ 590 600 610 620 630 640 670 680 690 700 710 720 pF1KE4 LATDQMLLHFGNLAMHMNGELVLRKARSLLYQFRLLPRIPCSLHDLCKLCGSGMWDSGSM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LATDQMLLHFGNLAMHMNGELVLRKARSLLYQFRLLPRIPCSLHDLCKLCGSGMWDSGSM 650 660 670 680 690 700 730 740 750 760 pF1KE4 PAVECTGHHPGSESCPYGGTVEMPSPKSLREGKKGPKTPQDGFGFRR ::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PAVECTGHHPGSESCPYGGTVEMPSPKSLREGKKGPKTPQDGFGFRR 710 720 730 740 750 767 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 01:29:06 2016 done: Sun Nov 6 01:29:08 2016 Total Scan time: 13.660 Total Display time: 0.160 Function used was FASTA [36.3.4 Apr, 2011]