FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE6627, 220 aa 1>>>pF1KE6627 220 - 220 aa - 220 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.5451+/-0.000334; mu= 12.1102+/- 0.021 mean_var=63.5235+/-12.380, 0's: 0 Z-trim(115.2): 6 B-trim: 6 in 1/51 Lambda= 0.160919 statistics sampled from 25491 (25497) to 25491 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.687), E-opt: 0.2 (0.299), width: 16 Scan time: 4.250 The best scores are: opt bits E(85289) NP_003246 (OMIM: 188825) metalloproteinase inhibit ( 220) 1538 365.4 4e-101 NP_003247 (OMIM: 601915) metalloproteinase inhibit ( 224) 780 189.5 3.9e-48 NP_000353 (OMIM: 136900,188826) metalloproteinase ( 211) 686 167.6 1.4e-41 NP_003245 (OMIM: 305370) metalloproteinase inhibit ( 207) 554 137.0 2.2e-32 XP_016885255 (OMIM: 305370) PREDICTED: metalloprot ( 261) 154 44.2 0.00025 >>NP_003246 (OMIM: 188825) metalloproteinase inhibitor 2 (220 aa) initn: 1538 init1: 1538 opt: 1538 Z-score: 1936.4 bits: 365.4 E(85289): 4e-101 Smith-Waterman score: 1538; 100.0% identity (100.0% similar) in 220 aa overlap (1-220:1-220) 10 20 30 40 50 60 pF1KE6 MGAAARTLRLALGLLLLATLLRPADACSCSPVHPQQAFCNADVVIRAKAVSEKEVDSGND :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 MGAAARTLRLALGLLLLATLLRPADACSCSPVHPQQAFCNADVVIRAKAVSEKEVDSGND 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 IYGNPIKRIQYEIKQIKMFKGPEKDIEFIYTAPSSAVCGVSLDVGGKKEYLIAGKAEGDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 IYGNPIKRIQYEIKQIKMFKGPEKDIEFIYTAPSSAVCGVSLDVGGKKEYLIAGKAEGDG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 KMHITLCDFIVPWDTLSTTQKKSLNHRYQMGCECKITRCPMIPCYISSPDECLWMDWVTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 KMHITLCDFIVPWDTLSTTQKKSLNHRYQMGCECKITRCPMIPCYISSPDECLWMDWVTE 130 140 150 160 170 180 190 200 210 220 pF1KE6 KNINGHQAKFFACIKRSDGSCAWYRGAAPPKQEFLDIEDP :::::::::::::::::::::::::::::::::::::::: NP_003 KNINGHQAKFFACIKRSDGSCAWYRGAAPPKQEFLDIEDP 190 200 210 220 >>NP_003247 (OMIM: 601915) metalloproteinase inhibitor 4 (224 aa) initn: 812 init1: 564 opt: 780 Z-score: 985.2 bits: 189.5 E(85289): 3.9e-48 Smith-Waterman score: 780; 50.0% identity (80.2% similar) in 212 aa overlap (14-220:14-224) 10 20 30 40 50 pF1KE6 MGAAARTLRLALGLLLLATLLRP---ADACSCSPVHPQQAFCNADVVIRAKAVSEKEVDS :: : .:::: ..::::.:.:::: .:.. .::::: ::: : . NP_003 MPGSPRPAPSWVLLLRLLALLRPPGLGEACSCAPAHPQQHICHSALVIRAKISSEKVVPA 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE6 GNDIYGNPIKRIQYEIKQIKMFKGPEK--DIEFIYTAPSSAVCGVSLDVGGKKEYLIAGK . : .. : ..::::::::::: :: :...::: .:..:::.:.....:.::..:. NP_003 SADP-ADTEKMLRYEIKQIKMFKGFEKVKDVQYIYTPFDSSLCGVKLEANSQKQYLLTGQ 70 80 90 100 110 120 130 140 150 160 170 pF1KE6 AEGDGKMHITLCDFIVPWDTLSTTQKKSLNHRYQMGCECKITRCPMIPCYISSPDECLWM . .:::. : ::..: ::. :: .:..::::.:...: :.:: : .:: ::.:.:::: NP_003 VLSDGKVFIHLCNYIEPWEDLSLVQRESLNHHYHLNCGCQITTCYTVPCTISAPNECLWT 120 130 140 150 160 170 180 190 200 210 220 pF1KE6 DWVTEKNINGHQAKFFACIKRSDGSCAWYRGAAPPKQEFLDIEDP ::. :... :.::. ..:.:. ::.:.:::: : ..::.:: .: NP_003 DWLLERKLYGYQAQHYVCMKHVDGTCSWYRGHLPLRKEFVDIVQP 180 190 200 210 220 >>NP_000353 (OMIM: 136900,188826) metalloproteinase inhi (211 aa) initn: 616 init1: 456 opt: 686 Z-score: 867.7 bits: 167.6 E(85289): 1.4e-41 Smith-Waterman score: 686; 45.2% identity (75.4% similar) in 199 aa overlap (24-220:21-211) 10 20 30 40 50 60 pF1KE6 MGAAARTLRLALGLLLLATLLRPADACSCSPVHPQQAFCNADVVIRAKAVSEKEVDSGND :.::.::: :::.::::.:.:::::.:..: : : NP_000 MTPWLGLIVLLGSWSLGDWGAEACTCSPSHPQDAFCNSDIVIRAKVVGKKLVKEG-- 10 20 30 40 50 70 80 90 100 110 pF1KE6 IYGNPIKRIQYEIKQIKMFKGPEK--DIEFIYTAPSSAVCGVSLDVGGKKEYLIAGKAEG :. . : :::.::..: : ...:.: : ..::..:.:. : .::..:.. NP_000 ----PFGTLVYTIKQMKMYRGFTKMPHVQYIHTEASESLCGLKLEVN-KYQYLLTGRVY- 60 70 80 90 100 120 130 140 150 160 170 pF1KE6 DGKMHITLCDFIVPWDTLSTTQKKSLNHRYQMGCECKITRCPMIPCYISSPDECLWMDWV ::::. ::.:. :: :. .:.:.::.::..::.::: : ..::...: .:::: : . NP_000 DGKMYTGLCNFVERWDQLTLSQRKGLNYRYHLGCNCKIKSCYYLPCFVTSKNECLWTDML 110 120 130 140 150 160 180 190 200 210 220 pF1KE6 TEKNINGHQAKFFACIKRSDGSCAWYRGAAPPKQEFLDIEDP .. . :.:.: .:::... : :.:::: ::: . ... :: NP_000 SNFGYPGYQSKHYACIRQKGGYCSWYRGWAPPDKSIINATDP 170 180 190 200 210 >>NP_003245 (OMIM: 305370) metalloproteinase inhibitor 1 (207 aa) initn: 547 init1: 199 opt: 554 Z-score: 702.2 bits: 137.0 E(85289): 2.2e-32 Smith-Waterman score: 554; 42.3% identity (67.2% similar) in 201 aa overlap (10-203:7-199) 10 20 30 40 50 60 pF1KE6 MGAAARTLRLALGLLLLATLLRPADACSCSPVHPQQAFCNADVVIRAKAVSEKEVDSGND :: :.::: :. :. ::.: : ::: ::::.:.::::: :. ::.. . NP_003 MAPFEPLASGILLLLWLIAPSRACTCVPPHPQTAFCNSDLVIRAKFVGTPEVNQ-TT 10 20 30 40 50 70 80 90 100 110 pF1KE6 IYGNPIKRIQYEIKQIKMFKGPEK-----DIEFIYTAPSSAVCGVSLDVGGK-KEYLIAG .: .::::. ::.:: . ::.:.:: .::: .. .:.:::: NP_003 LYQ------RYEIKMTKMYKGFQALGDAADIRFVYTPAMESVCGYFHRSHNRSEEFLIAG 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE6 KAEGDGKMHITLCDFIVPWDTLSTTQKKSLNHRYQMGCE-CKITRCPMIPCYISSPDECL : . :: .::: :.:..::..:: .:...... : .::: : . : ::: ..: .:: NP_003 KLQ-DGLLHITTCSFVAPWNSLSLAQRRGFTKTYTVGCEECTVFPCLSIPCKLQSGTHCL 120 130 140 150 160 180 190 200 210 220 pF1KE6 WMDWVTEKNINGHQAKFFACIKRSDGSCAWYRGAAPPKQEFLDIEDP : : . . . .: :.. .::. : : :.: NP_003 WTDQLLQGSEKGFQSRHLACLPREPGLCTWQSLRSQIA 170 180 190 200 >>XP_016885255 (OMIM: 305370) PREDICTED: metalloproteina (261 aa) initn: 184 init1: 146 opt: 154 Z-score: 198.7 bits: 44.2 E(85289): 0.00025 Smith-Waterman score: 154; 42.2% identity (80.0% similar) in 45 aa overlap (114-157:104-147) 90 100 110 120 130 140 pF1KE6 KDIEFIYTAPSSAVCGVSLDVGGKKEYLIAGKAEGDGKMHITLCDFIVPWDTLSTTQKKS :: . :: .::: :.:..::..:: .:... XP_016 FSLSEGRAFGSLAAQPITSCLSVPAPPFSLGKLQ-DGLLHITTCSFVAPWNSLSLAQRRG 80 90 100 110 120 130 150 160 170 180 190 200 pF1KE6 LNHRYQMGCE-CKITRCPMIPCYISSPDECLWMDWVTEKNINGHQAKFFACIKRSDGSCA ... : .::: : .. XP_016 FTKTYTVGCEECTVSAWTLTSNGRSFPGPFPKSWACFLLPLAILCPCGCSPTLRAVPDLS 140 150 160 170 180 190 220 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 14:55:05 2016 done: Tue Nov 8 14:55:05 2016 Total Scan time: 4.250 Total Display time: -0.020 Function used was FASTA [36.3.4 Apr, 2011]