FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE4126, 517 aa 1>>>pF1KE4126 517 - 517 aa - 517 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.4588+/-0.000328; mu= 16.9891+/- 0.021 mean_var=219.7080+/-46.858, 0's: 0 Z-trim(122.5): 199 B-trim: 2102 in 2/53 Lambda= 0.086527 statistics sampled from 40516 (40799) to 40516 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.793), E-opt: 0.2 (0.478), width: 16 Scan time: 12.280 The best scores are: opt bits E(85289) NP_660215 (OMIM: 607868) E3 ubiquitin-protein liga ( 468) 362 57.9 7.7e-08 XP_016857901 (OMIM: 607868) PREDICTED: E3 ubiquiti ( 467) 360 57.6 9.2e-08 XP_016857118 (OMIM: 616755) PREDICTED: E3 ubiquiti ( 555) 344 55.8 4e-07 NP_060677 (OMIM: 616755) E3 ubiquitin-protein liga ( 475) 342 55.4 4.4e-07 XP_011542587 (OMIM: 607868) PREDICTED: E3 ubiquiti ( 391) 335 54.4 7.2e-07 XP_016873951 (OMIM: 608487) PREDICTED: tripartite ( 300) 328 53.4 1.1e-06 XP_005253241 (OMIM: 608487) PREDICTED: tripartite ( 326) 328 53.4 1.2e-06 NP_149084 (OMIM: 608487) tripartite motif-containi ( 326) 328 53.4 1.2e-06 NP_149083 (OMIM: 608487) tripartite motif-containi ( 347) 328 53.5 1.2e-06 NP_477514 (OMIM: 607564) tripartite motif-containi ( 488) 328 53.7 1.5e-06 XP_016873952 (OMIM: 608487) PREDICTED: tripartite ( 265) 324 52.8 1.5e-06 XP_006718421 (OMIM: 608487) PREDICTED: tripartite ( 265) 324 52.8 1.5e-06 NP_149023 (OMIM: 608487) tripartite motif-containi ( 493) 328 53.7 1.5e-06 XP_005253240 (OMIM: 608487) PREDICTED: tripartite ( 493) 328 53.7 1.5e-06 NP_001003818 (OMIM: 607564) tripartite motif-conta ( 516) 328 53.7 1.5e-06 XP_016873950 (OMIM: 608487) PREDICTED: tripartite ( 310) 324 52.9 1.6e-06 XP_011518728 (OMIM: 608487) PREDICTED: tripartite ( 310) 324 52.9 1.6e-06 XP_011518729 (OMIM: 608487) PREDICTED: tripartite ( 271) 322 52.6 1.8e-06 XP_016873949 (OMIM: 608487) PREDICTED: tripartite ( 314) 322 52.6 2e-06 XP_016856908 (OMIM: 606123) PREDICTED: E3 ubiquiti ( 262) 315 51.7 3.3e-06 XP_016856907 (OMIM: 606123) PREDICTED: E3 ubiquiti ( 262) 315 51.7 3.3e-06 NP_001128327 (OMIM: 606123) E3 ubiquitin-protein l ( 343) 315 51.8 3.8e-06 XP_006711842 (OMIM: 606123) PREDICTED: E3 ubiquiti ( 477) 315 52.0 4.6e-06 NP_057186 (OMIM: 606123) E3 ubiquitin-protein liga ( 477) 315 52.0 4.6e-06 XP_011542512 (OMIM: 606123) PREDICTED: E3 ubiquiti ( 477) 315 52.0 4.6e-06 NP_001020111 (OMIM: 606123) E3 ubiquitin-protein l ( 477) 315 52.0 4.6e-06 XP_011542511 (OMIM: 606123) PREDICTED: E3 ubiquiti ( 477) 315 52.0 4.6e-06 NP_976038 (OMIM: 609315) tripartite motif-containi ( 511) 314 52.0 5.2e-06 NP_006501 (OMIM: 602165) zinc finger protein RFP [ ( 513) 313 51.8 5.6e-06 NP_006065 (OMIM: 606559) E3 ubiquitin-protein liga ( 498) 306 50.9 1e-05 NP_001186502 (OMIM: 606559) E3 ubiquitin-protein l ( 494) 304 50.7 1.2e-05 XP_011512566 (OMIM: 609316) PREDICTED: E3 ubiquiti ( 424) 302 50.3 1.3e-05 NP_067076 (OMIM: 605700) E3 ubiquitin-protein liga ( 518) 303 50.6 1.3e-05 NP_439893 (OMIM: 605701) tripartite motif-containi ( 395) 300 50.0 1.5e-05 NP_006769 (OMIM: 605701) tripartite motif-containi ( 481) 300 50.2 1.7e-05 XP_011512567 (OMIM: 609316) PREDICTED: E3 ubiquiti ( 421) 296 49.6 2.2e-05 NP_008959 (OMIM: 609316) E3 ubiquitin-protein liga ( 425) 296 49.6 2.2e-05 XP_011512568 (OMIM: 609316) PREDICTED: E3 ubiquiti ( 261) 287 48.2 3.7e-05 NP_742013 (OMIM: 605700) E3 ubiquitin-protein liga ( 488) 288 48.7 4.8e-05 NP_569074 (OMIM: 605684) tripartite motif-containi ( 270) 283 47.7 5.3e-05 NP_005073 (OMIM: 600453) E3 ubiquitin/ISG15 ligase ( 630) 288 48.8 5.5e-05 XP_016866752 (OMIM: 600830) PREDICTED: tripartite ( 462) 285 48.3 6e-05 XP_011513161 (OMIM: 600830) PREDICTED: tripartite ( 462) 285 48.3 6e-05 XP_005249435 (OMIM: 600830) PREDICTED: tripartite ( 539) 285 48.4 6.5e-05 NP_003440 (OMIM: 600830) tripartite motif-containi ( 539) 285 48.4 6.5e-05 NP_001229712 (OMIM: 600830) tripartite motif-conta ( 539) 285 48.4 6.5e-05 XP_005249434 (OMIM: 600830) PREDICTED: tripartite ( 539) 285 48.4 6.5e-05 XP_005249433 (OMIM: 600830) PREDICTED: tripartite ( 539) 285 48.4 6.5e-05 XP_005249431 (OMIM: 600830) PREDICTED: tripartite ( 539) 285 48.4 6.5e-05 XP_005249432 (OMIM: 600830) PREDICTED: tripartite ( 539) 285 48.4 6.5e-05 >>NP_660215 (OMIM: 607868) E3 ubiquitin-protein ligase T (468 aa) initn: 343 init1: 159 opt: 362 Z-score: 261.7 bits: 57.9 E(85289): 7.7e-08 Smith-Waterman score: 508; 30.6% identity (52.2% similar) in 529 aa overlap (6-512:10-468) 10 20 30 40 50 pF1KE4 MAAQLLEEKLTCAICLGLYQDPVTLPCGHNFCGACIRDWWDR-CGK-ACPECREPF :.:. :::::: . ::: :::::: ::: : . : ::::::: NP_660 MAAPDLSTNLQEEATCAICLDYFTDPVMTDCGHNFCRECIRRCWGQPEGPYACPECRELS 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE4 PDGAELRRNVALSGVLEVVRAGPARDPGPDPGPGPDPAARCPRHGRPLELFCRTEGRCVC :. .:: : :. . :. :: : :.: : . :: : .:: :: : : .: NP_660 PQ-RNLRPNRPLAKMAEM-----ARRLHP---PSPVPQGVCPAHREPLAAFCGDELRLLC 70 80 90 100 110 120 130 140 150 160 170 pF1KE4 SVCTVR-ECRLHE-RALLDA-ERLKREAQLRASLEVTQQQATQAEGQLLELRKQSSQIQN ..: : :. : : :: : :: :.:. ::: ..: .: : .. :... NP_660 AACERSGEHWAHRVRPLQDAAEDLK--AKLEKSLEHLRKQMQDA----LLFQAQADE--- 120 130 140 150 160 180 190 200 210 220 pF1KE4 SACIL-ASWVSGKFSSLLQALEIQHTTALRSIEVAKTQALAQARDEEQ-----RLRVHLE .:.: . : .. ...: .: :: . . . : : : .::. ::: NP_660 -TCVLWQKMVESQRQNVLGEFE-----RLRRLLAEEEQQLLQRLEEEELEVLPRLREGAA 170 180 190 200 210 230 240 250 260 270 280 pF1KE4 AVARHGCRIRELLEQVDEQTFLQESQLLQPPGPLGPLTPLQWDEDQQLGDLKQLLSRLCG ..... .. ::. ... . : ::: :.:. : :. NP_660 HLGQQSAHLAELIAELEGRCQLPALGLLQ--------------------DIKDALRRVQD 220 230 240 250 290 300 310 320 330 340 pF1KE4 LLLEEGSHPGAPAKPVDLAPVEAPGPLAPVPSTVCPLRRKLWQNYR-NLTFDPVSANRHF . :. : ...:.: . ::. : ::: .: ..:.:: .:: .. NP_660 VKLQ----------PPEVVPMELR-TVCRVPGLVETLRR-----FRGDVTLDPDTANPEL 260 270 280 290 300 350 360 370 380 390 400 pF1KE4 YLSRQDQQVKH--CRQSRGPGGPGSFELWQVQCAQS-FQAGHHYWEVRASDH-SVTLGVS ::.. ..:.. ::. : .: :. .: : .:.:::::...:. : .::: NP_660 ILSEDRRSVQRGDLRQAL-PDSPERFDPGPCVLGQERFTSGRHYWEVEVGDRTSWALGVC 310 320 330 340 350 410 420 430 440 450 pF1KE4 YPQLPRCRLGPHTDNIGRGPCSWGLCVQEDSLQAWHNGEAQRLPGVSG--RLLGMDLDLA .. : . : ... : : : : ...:. . : . : .:. :: NP_660 RENVNRKEKG----ELSAGNGFWILVF----LGSYYNSSERALAPLRDPPRRVGIFLDYE 360 370 380 390 400 410 460 470 480 490 500 510 pF1KE4 SGCLTFYSLEPQTQPLYTFHAL-FNQPLTPVFWLLEGRT--LTLCHQPGAVFP-LGPQEE .: :.::: . :. : . :. : :.: : . .:.:. :. :.:: NP_660 AGHLSFYSATDGSL-LFIFPEIPFSGTLRPLFSPLSSSPTPMTICRPKGGSGDTLAPQ 420 430 440 450 460 pF1KE4 VLS >>XP_016857901 (OMIM: 607868) PREDICTED: E3 ubiquitin-pr (467 aa) initn: 343 init1: 159 opt: 360 Z-score: 260.4 bits: 57.6 E(85289): 9.2e-08 Smith-Waterman score: 518; 30.7% identity (52.3% similar) in 528 aa overlap (6-512:10-467) 10 20 30 40 50 pF1KE4 MAAQLLEEKLTCAICLGLYQDPVTLPCGHNFCGACIRDWWDR-CGK-ACPECREPF :.:. :::::: . ::: :::::: ::: : . : ::::::: XP_016 MAAPDLSTNLQEEATCAICLDYFTDPVMTDCGHNFCRECIRRCWGQPEGPYACPECRELS 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE4 PDGAELRRNVALSGVLEVVRAGPARDPGPDPGPGPDPAARCPRHGRPLELFCRTEGRCVC :. .:: : :. . :. :: : :.: : . :: : .:: :: : : .: XP_016 PQ-RNLRPNRPLAKMAEM-----ARRLHP---PSPVPQGVCPAHREPLAAFCGDELRLLC 70 80 90 100 110 120 130 140 150 160 170 pF1KE4 SVCTVR-ECRLHE-RALLDA-ERLKREAQLRASLEVTQQQATQAEGQLLELRKQSSQIQN ..: : :. : : :: : :: :.:. ::: ..: .: : .. :... XP_016 AACERSGEHWAHRVRPLQDAAEDLK--AKLEKSLEHLRKQMQDA----LLFQAQADE--- 120 130 140 150 160 180 190 200 210 220 pF1KE4 SACILASWVSGKFSSLLQALEIQHTTALRSIEVAKTQALAQARDEEQ-----RLRVHLEA .:.: . : .. ...: .: :: . . . : : : .::. ::: XP_016 -TCVLWQMVESQRQNVLGEFE-----RLRRLLAEEEQQLLQRLEEEELEVLPRLREGAAH 170 180 190 200 210 230 240 250 260 270 280 pF1KE4 VARHGCRIRELLEQVDEQTFLQESQLLQPPGPLGPLTPLQWDEDQQLGDLKQLLSRLCGL ..... .. ::. ... . : ::: :.:. : :. . XP_016 LGQQSAHLAELIAELEGRCQLPALGLLQ--------------------DIKDALRRVQDV 220 230 240 250 290 300 310 320 330 340 pF1KE4 LLEEGSHPGAPAKPVDLAPVEAPGPLAPVPSTVCPLRRKLWQNYR-NLTFDPVSANRHFY :. : ...:.: . ::. : ::: .: ..:.:: .:: .. XP_016 KLQ----------PPEVVPMELR-TVCRVPGLVETLRR-----FRGDVTLDPDTANPELI 260 270 280 290 300 350 360 370 380 390 400 pF1KE4 LSRQDQQVKH--CRQSRGPGGPGSFELWQVQCAQS-FQAGHHYWEVRASDH-SVTLGVSY ::.. ..:.. ::. : .: :. .: : .:.:::::...:. : .::: XP_016 LSEDRRSVQRGDLRQAL-PDSPERFDPGPCVLGQERFTSGRHYWEVEVGDRTSWALGVCR 310 320 330 340 350 410 420 430 440 450 pF1KE4 PQLPRCRLGPHTDNIGRGPCSWGLCVQEDSLQAWHNGEAQRLPGVSG--RLLGMDLDLAS .. : . : ... : : : : ...:. . : . : .:. :: . XP_016 ENVNRKEKG----ELSAGNGFWILVF----LGSYYNSSERALAPLRDPPRRVGIFLDYEA 360 370 380 390 400 410 460 470 480 490 500 510 pF1KE4 GCLTFYSLEPQTQPLYTFHAL-FNQPLTPVFWLLEGRT--LTLCHQPGAVFP-LGPQEEV : :.::: . :. : . :. : :.: : . .:.:. :. :.:: XP_016 GHLSFYSATDGSL-LFIFPEIPFSGTLRPLFSPLSSSPTPMTICRPKGGSGDTLAPQ 420 430 440 450 460 pF1KE4 LS >>XP_016857118 (OMIM: 616755) PREDICTED: E3 ubiquitin-pr (555 aa) initn: 275 init1: 165 opt: 344 Z-score: 248.8 bits: 55.8 E(85289): 4e-07 Smith-Waterman score: 393; 25.7% identity (51.8% similar) in 510 aa overlap (1-489:80-533) 10 20 30 pF1KE4 MAAQLLEEKLTCAICLGLYQDPVTLPCGHN .... :...: :.:::..:::::.: : : XP_016 HGGGEAAAATGSSDSAGSGLRGCAGPKRWLLSSRGLKDELLCSICLSIYQDPVSLGCEHY 50 60 70 80 90 100 40 50 60 70 80 pF1KE4 FCGACIRDWWDRC----GKACPECREPFPDGAELRRNVALSGVLEVVRAGPARDPGPDPG :: :: . : : .. :::::. : . : : .. :....: . : : XP_016 FCRRCITEHWVRQEAQGARDCPECRRTFAEPA-LAPSLKLANIVERYSSFPL-----DAI 110 120 130 140 150 160 90 100 110 120 130 140 pF1KE4 PGPDPAAR-CPRHGRPLELFCRTEGRCVCSVCTVRECRLHER----ALLDA-ERLKREAQ . ::: : : . ..::: :. .: : : :::. .. :: ..:.:: XP_016 LNARRAARPCQAHDK-VKLFCLTDRALLCFFCD--EPALHEQHQVTGIDDAFDELQRE-- 170 180 190 200 210 150 160 170 180 190 200 pF1KE4 LRASLEVTQQQATQAEGQLLELRKQSSQIQNSACILASWVSGKFSSLLQALEIQHTTALR :. .:.. :.. . : :..: .. ..:. : . .. : : . :. .. . :. XP_016 LKDQLQALQDSEREHTEALQLLKRQLAETKSSTKSLRTTIGEAFERLHRLLRERQKAMLE 220 230 240 250 260 270 210 220 230 240 250 260 pF1KE4 SIEVAKTQALAQARDEEQRLRVHLEAVARHGCRIRELLEQVDEQTFLQESQLLQPPGPLG .:. ...:.. ... :: .:. : . . ..: : ..:..::: XP_016 ELEADTARTLTDIEQKVQRYSQQLRKVQEGAQILQERLAETDRHTFL------------- 280 290 300 310 320 270 280 290 300 310 320 pF1KE4 PLTPLQWDEDQQLGDLKQLLSRLCGLLLEEGSHPGAPAKPVDLAPVEAPGPLAPVPSTVC . . .: :: : . : . :. . ::: . XP_016 -------------AGVASLSERLKGKIHETN------LTYEDFPTSKYTGPLQYT----- 330 340 350 360 330 340 350 360 370 pF1KE4 PLRRKLWQNYR----NLTFDPVSANRHFYLSRQDQQVKHCRQSRGP--GGPGSFELW-QV . ..:.:. . ::.:: .:.... :: . : . : .: :.. .: XP_016 -IWKSLFQDIHPVPAALTLDPGTAHQRLILSDDCTIVAYGNLHPQPLQDSPKRFDVEVSV 370 380 390 400 410 420 380 390 400 410 420 430 pF1KE4 QCAQSFQAGHHYWEVRASDHSV-TLGVSYPQLPRCRLGPHTDNIGRGPCSWGLC-VQEDS ...:..: ::::: ..... ..:... : .: : : :..:. XP_016 LGSEAFSSGVHYWEVVVAEKTQWVIGLAHEAASR------KGSIQIQPSRGFYCIVMHDG 430 440 450 460 470 440 450 460 470 480 pF1KE4 LQAWHNGEAQRLPGVSGRL--LGMDLDLASGCLTFYSLEPQTQPLYTFHALFNQPLTPVF : : .: .: .:. :: .: : ::. . .. ::::. : : : XP_016 NQYSACTEPWTRLNVRDKLDKVGVFLDYDQGLLIFYNADDMSW-LYTFREKFPGKLCSYF 480 490 500 510 520 530 490 500 510 pF1KE4 WLLEGRTLTLCHQPGAVFPLGPQEEVLS XP_016 SPGQSHANGKNVQPLRINTVRI 540 550 >>NP_060677 (OMIM: 616755) E3 ubiquitin-protein ligase T (475 aa) initn: 273 init1: 163 opt: 342 Z-score: 248.2 bits: 55.4 E(85289): 4.4e-07 Smith-Waterman score: 391; 25.9% identity (51.5% similar) in 505 aa overlap (6-489:5-453) 10 20 30 40 50 pF1KE4 MAAQLLEEKLTCAICLGLYQDPVTLPCGHNFCGACIRDWWDRC----GKACPECREPFPD :...: :.:::..:::::.: : : :: :: . : : .. :::::. : . NP_060 MACSLKDELLCSICLSIYQDPVSLGCEHYFCRRCITEHWVRQEAQGARDCPECRRTFAE 10 20 30 40 50 60 70 80 90 100 110 pF1KE4 GAELRRNVALSGVLEVVRAGPARDPGPDPGPGPDPAAR-CPRHGRPLELFCRTEGRCVCS : : .. :....: . : : . ::: : : . ..::: :. .: NP_060 PA-LAPSLKLANIVERYSSFPL-----DAILNARRAARPCQAHDK-VKLFCLTDRALLCF 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE4 VCTVRECRLHER----ALLDA-ERLKREAQLRASLEVTQQQATQAEGQLLELRKQSSQIQ : : :::. .. :: ..:.:: :. .:.. :.. . : :..: .. . NP_060 FCD--EPALHEQHQVTGIDDAFDELQRE--LKDQLQALQDSEREHTEALQLLKRQLAETK 120 130 140 150 160 180 190 200 210 220 230 pF1KE4 NSACILASWVSGKFSSLLQALEIQHTTALRSIEVAKTQALAQARDEEQRLRVHLEAVARH .:. : . .. : : . :. .. . :. .:. ...:.. ... :: .:. : . NP_060 SSTKSLRTTIGEAFERLHRLLRERQKAMLEELEADTARTLTDIEQKVQRYSQQLRKVQEG 170 180 190 200 210 220 240 250 260 270 280 290 pF1KE4 GCRIRELLEQVDEQTFLQESQLLQPPGPLGPLTPLQWDEDQQLGDLKQLLSRLCGLLLEE . ..: : ..:..::: . . .: :: : . : NP_060 AQILQERLAETDRHTFL--------------------------AGVASLSERLKGKIHET 230 240 250 260 300 310 320 330 340 pF1KE4 GSHPGAPAKPVDLAPVEAPGPLAPVPSTVCPLRRKLWQNYR----NLTFDPVSANRHFYL . :. . ::: . . ..:.:. . ::.:: .:.... : NP_060 N------LTYEDFPTSKYTGPLQYT------IWKSLFQDIHPVPAALTLDPGTAHQRLIL 270 280 290 300 310 350 360 370 380 390 400 pF1KE4 SRQDQQVKHCRQSRGP--GGPGSFELW-QVQCAQSFQAGHHYWEVRASDHSV-TLGVSYP : . : . : .: :.. .: ...:..: ::::: ..... ..:... NP_060 SDDCTIVAYGNLHPQPLQDSPKRFDVEVSVLGSEAFSSGVHYWEVVVAEKTQWVIGLAHE 320 330 340 350 360 370 410 420 430 440 450 pF1KE4 QLPRCRLGPHTDNIGRGPCSWGLC-VQEDSLQAWHNGEAQRLPGVSGRL--LGMDLDLAS : .: : : :..:. : : .: .: .:. :: . NP_060 AASR------KGSIQIQPSRGFYCIVMHDGNQYSACTEPWTRLNVRDKLDKVGVFLDYDQ 380 390 400 410 420 460 470 480 490 500 510 pF1KE4 GCLTFYSLEPQTQPLYTFHALFNQPLTPVFWLLEGRTLTLCHQPGAVFPLGPQEEVLS : : ::. . .. ::::. : : : NP_060 GLLIFYNADDMSW-LYTFREKFPGKLCSYFSPGQSHANGKNVQPLRINTVRI 430 440 450 460 470 >>XP_011542587 (OMIM: 607868) PREDICTED: E3 ubiquitin-pr (391 aa) initn: 370 init1: 159 opt: 335 Z-score: 244.3 bits: 54.4 E(85289): 7.2e-07 Smith-Waterman score: 349; 28.3% identity (45.3% similar) in 523 aa overlap (6-512:10-391) 10 20 30 40 50 pF1KE4 MAAQLLEEKLTCAICLGLYQDPVTLPCGHNFCGACIRDWWDR-CGK-ACPECREPF :.:. :::::: . ::: :::::: ::: : . : ::::::: XP_011 MAAPDLSTNLQEEATCAICLDYFTDPVMTDCGHNFCRECIRRCWGQPEGPYACPECRELS 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE4 PDGAELRRNVALSGVLEVVRAGPARDPGPDPGPGPDPAARCPRHGRPLELFCRTEGRCVC :. .:: : :. . :. :: : :.: : . :: : .:: :: : : .: XP_011 PQ-RNLRPNRPLAKMAEM-----ARRLHP---PSPVPQGVCPAHREPLAAFCGDELRLLC 70 80 90 100 110 120 130 140 150 160 170 pF1KE4 SVCTVR-ECRLHE-RALLDA-ERLKREAQLRASLEVTQQQATQAEGQLLELRKQSSQIQN ..: : :. : : :: : :: :.:. ::: ..: .: : .. :... XP_011 AACERSGEHWAHRVRPLQDAAEDLK--AKLEKSLEHLRKQMQDA----LLFQAQADE--- 120 130 140 150 160 180 190 200 210 220 230 pF1KE4 SACILASWVSGKFSSLLQALEIQHTTALRSIEVAKTQALAQARDEEQRLRVHLEAVARHG .:.: : . : ::: .. .: XP_011 -TCVL--WQDIK-------------DALRRVQDVK------------------------- 170 180 240 250 260 270 280 290 pF1KE4 CRIRELLEQVDEQTFLQESQLLQPPGPLGPLTPLQWDEDQQLGDLKQLLSRLCGLLLEEG :::: ..:.. : .: XP_011 ---------------------LQPP----EVVPME-------------LRTVCR------ 190 300 310 320 330 340 350 pF1KE4 SHPGAPAKPVDLAPVEAPGPLAPVPSTVCPLRRKLWQNYR-NLTFDPVSANRHFYLSRQD ::. : ::: .: ..:.:: .:: .. ::.. XP_011 -----------------------VPGLVETLRR-----FRGDVTLDPDTANPELILSEDR 200 210 220 360 370 380 390 400 pF1KE4 QQVKH--CRQSRGPGGPGSFELWQVQCAQS-FQAGHHYWEVRASDH-SVTLGVSYPQLPR ..:.. ::. : .: :. .: : .:.:::::...:. : .::: .. : XP_011 RSVQRGDLRQAL-PDSPERFDPGPCVLGQERFTSGRHYWEVEVGDRTSWALGVCRENVNR 230 240 250 260 270 280 410 420 430 440 450 460 pF1KE4 CRLGPHTDNIGRGPCSWGLCVQEDSLQAWHNGEAQRLPGVSG--RLLGMDLDLASGCLTF . : ... : : : : ...:. . : . : .:. :: .: :.: XP_011 KEKG----ELSAGNGFWILVF----LGSYYNSSERALAPLRDPPRRVGIFLDYEAGHLSF 290 300 310 320 330 340 470 480 490 500 510 pF1KE4 YSLEPQTQPLYTFHAL-FNQPLTPVFWLLEGRT--LTLCHQPGAVFP-LGPQEEVLS :: . :. : . :. : :.: : . .:.:. :. :.:: XP_011 YSATDGSL-LFIFPEIPFSGTLRPLFSPLSSSPTPMTICRPKGGSGDTLAPQ 350 360 370 380 390 >>XP_016873951 (OMIM: 608487) PREDICTED: tripartite moti (300 aa) initn: 242 init1: 138 opt: 328 Z-score: 240.7 bits: 53.4 E(85289): 1.1e-06 Smith-Waterman score: 339; 30.0% identity (56.8% similar) in 280 aa overlap (1-256:1-265) 10 20 30 40 50 pF1KE4 MAAQLL---EEKLTCAICLGLYQDPVTLPCGHNFCGACI-----RDWWDRCGKACPECRE ::. .: .:..:: ::: : .:..: :::.:: ::. .. :. ..:: :: XP_016 MASGILVNVKEEVTCPICLELLTQPLSLDCGHSFCQACLTANHKKSMLDKGESSCPVCRI 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE4 PF-PDGAELRRNVALSGVLEVVRAGPARDPGPDPGPGPDPAARCPRHGRPLELFCRTEGR . :.. . :.:: ...: .: : . . .: :::. : :::. .:. XP_016 SYQPENIRPNRHVA--NIVEKLREVKLSPEG-------QKVDHCARHGEKLLLFCQEDGK 70 80 90 100 110 120 130 140 150 160 pF1KE4 CVCSVCT-VRECRLHERALLDAERLKREAQ--LRASLEVTQQQATQAEGQLLELRKQS-- .: .: .: : :. : .:.. :: : :.:.::. .:. .:: ..:... XP_016 VICWLCERSQEHRGHHTFL--TEEVAREYQVKLQAALEMLRQKQQEAEELEADIREEKAS 120 130 140 150 160 170 180 190 200 210 pF1KE4 --SQIQ-NSACILASW------VSGKFSSLLQALEIQHTTALRSIEVAKTQALAQARDEE .::: ... .::.. .. . :. :: :: .. :.:. ..:. . :. XP_016 WKTQIQYDKTNVLADFEQLRDILDWEESNELQNLEKEEEDILKSLTNSETEMVQQT---- 170 180 190 200 210 220 220 230 240 250 260 270 pF1KE4 QRLRVHLEAVA-RHGCRIRELLEQVDEQTFLQESQLLQPPGPLGPLTPLQWDEDQQLGDL : :: . . : . :::. :: :. :. : XP_016 QSLRELISDLEHRLQGSVMELLQGVDGVIKRTENVTLKKPETFPKNQRRVFRAPDLKGML 230 240 250 260 270 280 280 290 300 310 320 330 pF1KE4 KQLLSRLCGLLLEEGSHPGAPAKPVDLAPVEAPGPLAPVPSTVCPLRRKLWQNYRNLTFD XP_016 EVFRELTDVRRYWED 290 300 >>XP_005253241 (OMIM: 608487) PREDICTED: tripartite moti (326 aa) initn: 242 init1: 138 opt: 328 Z-score: 240.4 bits: 53.4 E(85289): 1.2e-06 Smith-Waterman score: 339; 30.0% identity (56.8% similar) in 280 aa overlap (1-256:1-265) 10 20 30 40 50 pF1KE4 MAAQLL---EEKLTCAICLGLYQDPVTLPCGHNFCGACI-----RDWWDRCGKACPECRE ::. .: .:..:: ::: : .:..: :::.:: ::. .. :. ..:: :: XP_005 MASGILVNVKEEVTCPICLELLTQPLSLDCGHSFCQACLTANHKKSMLDKGESSCPVCRI 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE4 PF-PDGAELRRNVALSGVLEVVRAGPARDPGPDPGPGPDPAARCPRHGRPLELFCRTEGR . :.. . :.:: ...: .: : . . .: :::. : :::. .:. XP_005 SYQPENIRPNRHVA--NIVEKLREVKLSPEG-------QKVDHCARHGEKLLLFCQEDGK 70 80 90 100 110 120 130 140 150 160 pF1KE4 CVCSVCT-VRECRLHERALLDAERLKREAQ--LRASLEVTQQQATQAEGQLLELRKQS-- .: .: .: : :. : .:.. :: : :.:.::. .:. .:: ..:... XP_005 VICWLCERSQEHRGHHTFL--TEEVAREYQVKLQAALEMLRQKQQEAEELEADIREEKAS 120 130 140 150 160 170 180 190 200 210 pF1KE4 --SQIQ-NSACILASW------VSGKFSSLLQALEIQHTTALRSIEVAKTQALAQARDEE .::: ... .::.. .. . :. :: :: .. :.:. ..:. . :. XP_005 WKTQIQYDKTNVLADFEQLRDILDWEESNELQNLEKEEEDILKSLTNSETEMVQQT---- 170 180 190 200 210 220 220 230 240 250 260 270 pF1KE4 QRLRVHLEAVA-RHGCRIRELLEQVDEQTFLQESQLLQPPGPLGPLTPLQWDEDQQLGDL : :: . . : . :::. :: :. :. : XP_005 QSLRELISDLEHRLQGSVMELLQGVDGVIKRTENVTLKKPETFPKNQRRVFRAPDLKGML 230 240 250 260 270 280 280 290 300 310 320 330 pF1KE4 KQLLSRLCGLLLEEGSHPGAPAKPVDLAPVEAPGPLAPVPSTVCPLRRKLWQNYRNLTFD XP_005 EVFRELTDVRRYWGWSAMARSRFTATSTSQIQAILLPQPPK 290 300 310 320 >>NP_149084 (OMIM: 608487) tripartite motif-containing p (326 aa) initn: 242 init1: 138 opt: 328 Z-score: 240.4 bits: 53.4 E(85289): 1.2e-06 Smith-Waterman score: 339; 30.0% identity (56.8% similar) in 280 aa overlap (1-256:1-265) 10 20 30 40 50 pF1KE4 MAAQLL---EEKLTCAICLGLYQDPVTLPCGHNFCGACI-----RDWWDRCGKACPECRE ::. .: .:..:: ::: : .:..: :::.:: ::. .. :. ..:: :: NP_149 MASGILVNVKEEVTCPICLELLTQPLSLDCGHSFCQACLTANHKKSMLDKGESSCPVCRI 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE4 PF-PDGAELRRNVALSGVLEVVRAGPARDPGPDPGPGPDPAARCPRHGRPLELFCRTEGR . :.. . :.:: ...: .: : . . .: :::. : :::. .:. NP_149 SYQPENIRPNRHVA--NIVEKLREVKLSPEG-------QKVDHCARHGEKLLLFCQEDGK 70 80 90 100 110 120 130 140 150 160 pF1KE4 CVCSVCT-VRECRLHERALLDAERLKREAQ--LRASLEVTQQQATQAEGQLLELRKQS-- .: .: .: : :. : .:.. :: : :.:.::. .:. .:: ..:... NP_149 VICWLCERSQEHRGHHTFL--TEEVAREYQVKLQAALEMLRQKQQEAEELEADIREEKAS 120 130 140 150 160 170 180 190 200 210 pF1KE4 --SQIQ-NSACILASW------VSGKFSSLLQALEIQHTTALRSIEVAKTQALAQARDEE .::: ... .::.. .. . :. :: :: .. :.:. ..:. . :. NP_149 WKTQIQYDKTNVLADFEQLRDILDWEESNELQNLEKEEEDILKSLTNSETEMVQQT---- 170 180 190 200 210 220 220 230 240 250 260 270 pF1KE4 QRLRVHLEAVA-RHGCRIRELLEQVDEQTFLQESQLLQPPGPLGPLTPLQWDEDQQLGDL : :: . . : . :::. :: :. :. : NP_149 QSLRELISDLEHRLQGSVMELLQGVDGVIKRTENVTLKKPETFPKNQRRVFRAPDLKGML 230 240 250 260 270 280 280 290 300 310 320 330 pF1KE4 KQLLSRLCGLLLEEGSHPGAPAKPVDLAPVEAPGPLAPVPSTVCPLRRKLWQNYRNLTFD NP_149 EVFRELTDVRRYWGWSAMARSRFTATSTSQIQAILLPQPPK 290 300 310 320 >>NP_149083 (OMIM: 608487) tripartite motif-containing p (347 aa) initn: 242 init1: 138 opt: 328 Z-score: 240.1 bits: 53.5 E(85289): 1.2e-06 Smith-Waterman score: 339; 30.0% identity (56.8% similar) in 280 aa overlap (1-256:1-265) 10 20 30 40 50 pF1KE4 MAAQLL---EEKLTCAICLGLYQDPVTLPCGHNFCGACI-----RDWWDRCGKACPECRE ::. .: .:..:: ::: : .:..: :::.:: ::. .. :. ..:: :: NP_149 MASGILVNVKEEVTCPICLELLTQPLSLDCGHSFCQACLTANHKKSMLDKGESSCPVCRI 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE4 PF-PDGAELRRNVALSGVLEVVRAGPARDPGPDPGPGPDPAARCPRHGRPLELFCRTEGR . :.. . :.:: ...: .: : . . .: :::. : :::. .:. NP_149 SYQPENIRPNRHVA--NIVEKLREVKLSPEG-------QKVDHCARHGEKLLLFCQEDGK 70 80 90 100 110 120 130 140 150 160 pF1KE4 CVCSVCT-VRECRLHERALLDAERLKREAQ--LRASLEVTQQQATQAEGQLLELRKQS-- .: .: .: : :. : .:.. :: : :.:.::. .:. .:: ..:... NP_149 VICWLCERSQEHRGHHTFL--TEEVAREYQVKLQAALEMLRQKQQEAEELEADIREEKAS 120 130 140 150 160 170 180 190 200 210 pF1KE4 --SQIQ-NSACILASW------VSGKFSSLLQALEIQHTTALRSIEVAKTQALAQARDEE .::: ... .::.. .. . :. :: :: .. :.:. ..:. . :. NP_149 WKTQIQYDKTNVLADFEQLRDILDWEESNELQNLEKEEEDILKSLTNSETEMVQQT---- 170 180 190 200 210 220 220 230 240 250 260 270 pF1KE4 QRLRVHLEAVA-RHGCRIRELLEQVDEQTFLQESQLLQPPGPLGPLTPLQWDEDQQLGDL : :: . . : . :::. :: :. :. : NP_149 QSLRELISDLEHRLQGSVMELLQGVDGVIKRTENVTLKKPETFPKNQRRVFRAPDLKGML 230 240 250 260 270 280 280 290 300 310 320 330 pF1KE4 KQLLSRLCGLLLEEGSHPGAPAKPVDLAPVEAPGPLAPVPSTVCPLRRKLWQNYRNLTFD NP_149 EVFRELTDVRRYWGKEKSHYHKPPCGLSLLLSLSFRILCSLLGSCFKIYDSPSKTHITYP 290 300 310 320 330 340 >>NP_477514 (OMIM: 607564) tripartite motif-containing p (488 aa) initn: 349 init1: 140 opt: 328 Z-score: 238.6 bits: 53.7 E(85289): 1.5e-06 Smith-Waterman score: 413; 25.5% identity (52.0% similar) in 521 aa overlap (6-489:9-472) 10 20 30 40 50 pF1KE4 MAAQLLEEKLTCAICLGLYQDPVTLPCGHNFCGACI-----RDWWDRCG-KACPECR ..:..:: ::: : .:... :::.:: ::: .. . : ..:: :. NP_477 MTSPVLVDIREEVTCPICLELLTEPLSIDCGHSFCQACITPNGRESVIGQEGERSCPVCQ 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE4 EPFPDGAELRRNVALSGVLEVVRAGPARDPGPDPGPGPD-PAARCPRHGRPLELFCRTEG . : .:: : :..... .: ::: . :. : ::. :.:::. .: NP_477 TSYQPG-NLRPNRHLANIVRRLREVVL-------GPGKQLKAVLCADHGEKLQLFCQEDG 70 80 90 100 110 120 130 140 150 160 pF1KE4 RCVCSVCT-VRECRLHERALLDAERLKREAQLRASLEVTQQQATQAEGQLLELRKQSSQI . .: .: .: : :. :.. . . ... ::. ... .:: .:..... NP_477 KVICWLCERSQEHRGHHTFLVEEVAQEYQEKFQESLKKLKNEEQEAEKLTAFIREKKTSW 120 130 140 150 160 170 170 180 190 200 210 pF1KE4 QNSACILASWVSGKFSSL-----------LQALEIQHTTALRSIEVAKTQALAQARDEEQ .:. .. .:..: :. :: .. .:: :: :... . :. : NP_477 KNQMEPERCRIQTEFNQLRNILDRVEQRELKKLEQEEKKGLRIIEEAENDLVHQT----Q 180 190 200 210 220 220 230 240 250 260 270 pF1KE4 RLRVHLEAVARHGCR--IRELLEQVDEQTFLQESQLLQPPGPLGPLTPLQWDEDQQLGDL :: . . :. :. :::..:.. : .: :. : : : . . :: NP_477 SLRELISDLERR-CQGSTMELLQDVSDVTERSEFWTLRKPEAL----PTKLRSMFRAPDL 230 240 250 260 270 280 280 290 300 310 320 330 pF1KE4 KQLLSRLCGLLLEEGSHPGAPAKPVDLAPVEAPGPLAPVPSTVCPLRRKLWQNYRNLTFD :..: :.: : . :. : ..:.. NP_477 KRML-RVCRELTDVQSY---------------------------------WV---DVTLN 290 300 340 350 360 370 380 390 pF1KE4 PVSANRHFYLSRQDQQVKHCRQSRGPGGPGSFELWQVQCA----QSFQAGHHYWEVRASD : .:: .. :... .::. . .::. .: . .:. : :..:.::::: .. NP_477 PHTANLNLVLAKNRRQVRFVGAKV--SGPSCLEK-HYDCSVLGSQHFSSGKHYWEVDVAK 310 320 330 340 350 360 400 410 420 430 440 pF1KE4 HSV-TLGVSYPQL-PRCRLGPHTDN---IGR-GPCS--WGLCVQEDS-LQAWHNGEAQRL ... ::: .: : .. ..: .: : : : . .:.. .:.... . : NP_477 KTAWILGVCSNSLGPTFSFNHFAQNHSAYSRYQPQSGYWVIGLQHNHEYRAYEDSSPSLL 370 380 390 400 410 420 450 460 470 480 490 500 pF1KE4 PG--VSGRLLGMDLDLASGCLTFYSLEPQTQPLYTFHAL-FNQPLTPVFWLLEGRTLTLC . : : .:. :: .: ..::.. . :.::: : : : : NP_477 LSMTVPPRRVGVFLDYEAGTVSFYNVTNHGFPIYTFSKYYFPTTLCPYFNPCNCVIPMTL 430 440 450 460 470 480 510 pF1KE4 HQPGAVFPLGPQEEVLS NP_477 RRPSS 517 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 03:38:33 2016 done: Sun Nov 6 03:38:35 2016 Total Scan time: 12.280 Total Display time: 0.050 Function used was FASTA [36.3.4 Apr, 2011]