FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE3810, 407 aa 1>>>pF1KE3810 407 - 407 aa - 407 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.1576+/-0.000387; mu= 18.3261+/- 0.024 mean_var=68.7708+/-13.687, 0's: 0 Z-trim(112.8): 20 B-trim: 1031 in 1/52 Lambda= 0.154658 statistics sampled from 21885 (21904) to 21885 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.627), E-opt: 0.2 (0.257), width: 16 Scan time: 7.520 The best scores are: opt bits E(85289) NP_002602 (OMIM: 602525) pyruvate dehydrogenase ki ( 407) 2723 616.7 3.2e-176 NP_001186828 (OMIM: 602525) pyruvate dehydrogenase ( 343) 2292 520.5 2.5e-147 NP_001186827 (OMIM: 602525) pyruvate dehydrogenase ( 343) 2292 520.5 2.5e-147 NP_002601 (OMIM: 602524) [Pyruvate dehydrogenase ( ( 436) 1959 446.2 7e-125 NP_005382 (OMIM: 300906) pyruvate dehydrogenase ki ( 406) 1876 427.7 2.5e-119 NP_001135858 (OMIM: 300906) pyruvate dehydrogenase ( 415) 1876 427.7 2.5e-119 NP_002603 (OMIM: 602527) pyruvate dehydrogenase ki ( 411) 1850 421.9 1.4e-117 XP_011509647 (OMIM: 602524) PREDICTED: pyruvate de ( 360) 1764 402.7 7.5e-112 XP_011509649 (OMIM: 602524) PREDICTED: pyruvate de ( 380) 1487 340.9 3.2e-93 XP_011509645 (OMIM: 602524) PREDICTED: pyruvate de ( 380) 1487 340.9 3.2e-93 XP_011509646 (OMIM: 602524) PREDICTED: pyruvate de ( 380) 1487 340.9 3.2e-93 NP_001265478 (OMIM: 602524) [Pyruvate dehydrogenas ( 456) 1487 340.9 3.7e-93 NP_001186829 (OMIM: 602525) pyruvate dehydrogenase ( 199) 1146 264.6 1.5e-70 XP_006712658 (OMIM: 602524) PREDICTED: pyruvate de ( 244) 1146 264.7 1.8e-70 XP_006712657 (OMIM: 602524) PREDICTED: pyruvate de ( 281) 474 114.8 2.7e-25 NP_005872 (OMIM: 614901,614923) [3-methyl-2-oxobut ( 412) 288 73.4 1.2e-12 NP_001116429 (OMIM: 614901,614923) [3-methyl-2-oxo ( 365) 258 66.7 1.1e-10 XP_016878348 (OMIM: 614901,614923) PREDICTED: 3-me ( 410) 258 66.7 1.2e-10 >>NP_002602 (OMIM: 602525) pyruvate dehydrogenase kinase (407 aa) initn: 2723 init1: 2723 opt: 2723 Z-score: 3284.7 bits: 616.7 E(85289): 3.2e-176 Smith-Waterman score: 2723; 100.0% identity (100.0% similar) in 407 aa overlap (1-407:1-407) 10 20 30 40 50 60 pF1KE3 MRWVWALLKNASLAGAPKYIEHFSKFSPSPLSMKQFLDFGSSNACEKTSFTFLRQELPVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 MRWVWALLKNASLAGAPKYIEHFSKFSPSPLSMKQFLDFGSSNACEKTSFTFLRQELPVR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 LANIMKEINLLPDRVLSTPSVQLVQSWYVQSLLDIMEFLDKDPEDHRTLSQFTDALVTIR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 LANIMKEINLLPDRVLSTPSVQLVQSWYVQSLLDIMEFLDKDPEDHRTLSQFTDALVTIR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 NRHNDVVPTMAQGVLEYKDTYGDDPVSNQNIQYFLDRFYLSRISIRMLINQHTLIFDGST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 NRHNDVVPTMAQGVLEYKDTYGDDPVSNQNIQYFLDRFYLSRISIRMLINQHTLIFDGST 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 NPAHPKHIGSIDPNCNVSEVVKDAYDMAKLLCDKYYMASPDLEIQEINAANSKQPIHMVY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 NPAHPKHIGSIDPNCNVSEVVKDAYDMAKLLCDKYYMASPDLEIQEINAANSKQPIHMVY 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 VPSHLYHMLFELFKNAMRATVESHESSLILPPIKVMVALGEEDLSIKMSDRGGGVPLRKI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 VPSHLYHMLFELFKNAMRATVESHESSLILPPIKVMVALGEEDLSIKMSDRGGGVPLRKI 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 ERLFSYMYSTAPTPQPGTGGTPLAGFGYGLPISRLYAKYFQGDLQLFSMEGFGTDAVIYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 ERLFSYMYSTAPTPQPGTGGTPLAGFGYGLPISRLYAKYFQGDLQLFSMEGFGTDAVIYL 310 320 330 340 350 360 370 380 390 400 pF1KE3 KALSTDSVERLPVYNKSAWRHYQTIQEAGDWCVPSTEPKNTSTYRVS ::::::::::::::::::::::::::::::::::::::::::::::: NP_002 KALSTDSVERLPVYNKSAWRHYQTIQEAGDWCVPSTEPKNTSTYRVS 370 380 390 400 >>NP_001186828 (OMIM: 602525) pyruvate dehydrogenase kin (343 aa) initn: 2292 init1: 2292 opt: 2292 Z-score: 2766.0 bits: 520.5 E(85289): 2.5e-147 Smith-Waterman score: 2292; 100.0% identity (100.0% similar) in 343 aa overlap (65-407:1-343) 40 50 60 70 80 90 pF1KE3 QFLDFGSSNACEKTSFTFLRQELPVRLANIMKEINLLPDRVLSTPSVQLVQSWYVQSLLD :::::::::::::::::::::::::::::: NP_001 MKEINLLPDRVLSTPSVQLVQSWYVQSLLD 10 20 30 100 110 120 130 140 150 pF1KE3 IMEFLDKDPEDHRTLSQFTDALVTIRNRHNDVVPTMAQGVLEYKDTYGDDPVSNQNIQYF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IMEFLDKDPEDHRTLSQFTDALVTIRNRHNDVVPTMAQGVLEYKDTYGDDPVSNQNIQYF 40 50 60 70 80 90 160 170 180 190 200 210 pF1KE3 LDRFYLSRISIRMLINQHTLIFDGSTNPAHPKHIGSIDPNCNVSEVVKDAYDMAKLLCDK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LDRFYLSRISIRMLINQHTLIFDGSTNPAHPKHIGSIDPNCNVSEVVKDAYDMAKLLCDK 100 110 120 130 140 150 220 230 240 250 260 270 pF1KE3 YYMASPDLEIQEINAANSKQPIHMVYVPSHLYHMLFELFKNAMRATVESHESSLILPPIK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YYMASPDLEIQEINAANSKQPIHMVYVPSHLYHMLFELFKNAMRATVESHESSLILPPIK 160 170 180 190 200 210 280 290 300 310 320 330 pF1KE3 VMVALGEEDLSIKMSDRGGGVPLRKIERLFSYMYSTAPTPQPGTGGTPLAGFGYGLPISR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VMVALGEEDLSIKMSDRGGGVPLRKIERLFSYMYSTAPTPQPGTGGTPLAGFGYGLPISR 220 230 240 250 260 270 340 350 360 370 380 390 pF1KE3 LYAKYFQGDLQLFSMEGFGTDAVIYLKALSTDSVERLPVYNKSAWRHYQTIQEAGDWCVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LYAKYFQGDLQLFSMEGFGTDAVIYLKALSTDSVERLPVYNKSAWRHYQTIQEAGDWCVP 280 290 300 310 320 330 400 pF1KE3 STEPKNTSTYRVS ::::::::::::: NP_001 STEPKNTSTYRVS 340 >>NP_001186827 (OMIM: 602525) pyruvate dehydrogenase kin (343 aa) initn: 2292 init1: 2292 opt: 2292 Z-score: 2766.0 bits: 520.5 E(85289): 2.5e-147 Smith-Waterman score: 2292; 100.0% identity (100.0% similar) in 343 aa overlap (65-407:1-343) 40 50 60 70 80 90 pF1KE3 QFLDFGSSNACEKTSFTFLRQELPVRLANIMKEINLLPDRVLSTPSVQLVQSWYVQSLLD :::::::::::::::::::::::::::::: NP_001 MKEINLLPDRVLSTPSVQLVQSWYVQSLLD 10 20 30 100 110 120 130 140 150 pF1KE3 IMEFLDKDPEDHRTLSQFTDALVTIRNRHNDVVPTMAQGVLEYKDTYGDDPVSNQNIQYF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IMEFLDKDPEDHRTLSQFTDALVTIRNRHNDVVPTMAQGVLEYKDTYGDDPVSNQNIQYF 40 50 60 70 80 90 160 170 180 190 200 210 pF1KE3 LDRFYLSRISIRMLINQHTLIFDGSTNPAHPKHIGSIDPNCNVSEVVKDAYDMAKLLCDK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LDRFYLSRISIRMLINQHTLIFDGSTNPAHPKHIGSIDPNCNVSEVVKDAYDMAKLLCDK 100 110 120 130 140 150 220 230 240 250 260 270 pF1KE3 YYMASPDLEIQEINAANSKQPIHMVYVPSHLYHMLFELFKNAMRATVESHESSLILPPIK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YYMASPDLEIQEINAANSKQPIHMVYVPSHLYHMLFELFKNAMRATVESHESSLILPPIK 160 170 180 190 200 210 280 290 300 310 320 330 pF1KE3 VMVALGEEDLSIKMSDRGGGVPLRKIERLFSYMYSTAPTPQPGTGGTPLAGFGYGLPISR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VMVALGEEDLSIKMSDRGGGVPLRKIERLFSYMYSTAPTPQPGTGGTPLAGFGYGLPISR 220 230 240 250 260 270 340 350 360 370 380 390 pF1KE3 LYAKYFQGDLQLFSMEGFGTDAVIYLKALSTDSVERLPVYNKSAWRHYQTIQEAGDWCVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LYAKYFQGDLQLFSMEGFGTDAVIYLKALSTDSVERLPVYNKSAWRHYQTIQEAGDWCVP 280 290 300 310 320 330 400 pF1KE3 STEPKNTSTYRVS ::::::::::::: NP_001 STEPKNTSTYRVS 340 >>NP_002601 (OMIM: 602524) [Pyruvate dehydrogenase (acet (436 aa) initn: 1964 init1: 840 opt: 1959 Z-score: 2363.0 bits: 446.2 E(85289): 7e-125 Smith-Waterman score: 1959; 69.6% identity (89.2% similar) in 398 aa overlap (11-405:37-434) 10 20 30 40 pF1KE3 MRWVWALLKNASLAGAPKYIEHFSKFSPSPLSMKQFLDFG :: :.: .. ...::::::::::::::: NP_002 LRGAALAGPGPGLRAAGFSRSFSSDSGSSPASERGVPGQVDFYARFSPSPLSMKQFLDFG 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE3 SSNACEKTSFTFLRQELPVRLANIMKEINLLPDRVLSTPSVQLVQSWYVQSLLDIMEFLD : :::::::: :::::::::::::::::.:::: .: :::::::::::.::: ....: : NP_002 SVNACEKTSFMFLRQELPVRLANIMKEISLLPDNLLRTPSVQLVQSWYIQSLQELLDFKD 70 80 90 100 110 120 110 120 130 140 150 160 pF1KE3 KDPEDHRTLSQFTDALVTIRNRHNDVVPTMAQGVLEYKDTYGDDPVSNQNIQYFLDRFYL :. :: ... .:::... ::::::::.:::::::.:::...: :::..::.::::::::. NP_002 KSAEDAKAIYDFTDTVIRIRNRHNDVIPTMAQGVIEYKESFGVDPVTSQNVQYFLDRFYM 130 140 150 160 170 180 170 180 190 200 210 pF1KE3 SRISIRMLINQHTLIFDGST--NPAHPKHIGSIDPNCNVSEVVKDAYDMAKLLCDKYYMA ::::::::.:::.:.: :. .:.: ::::::.::::: ::.::.:. :. ::: ::. NP_002 SRISIRMLLNQHSLLFGGKGKGSPSHRKHIGSINPNCNVLEVIKDGYENARRLCDLYYIN 190 200 210 220 230 240 220 230 240 250 260 270 pF1KE3 SPDLEIQEINAANSKQPIHMVYVPSHLYHMLFELFKNAMRATVESHESSLILPPIKVMVA ::.::..:.:: . :::..::::::::::.:::::::::::.: : . . :::.: :. NP_002 SPELELEELNAKSPGQPIQVVYVPSHLYHMVFELFKNAMRATMEHHANRGVYPPIQVHVT 250 260 270 280 290 300 280 290 300 310 320 330 pF1KE3 LGEEDLSIKMSDRGGGVPLRKIERLFSYMYSTAPTPQPGTG-GTPLAGFGYGLPISRLYA ::.:::..::::::::::::::.:::.::::::: :. :. ..:::::::::::::::: NP_002 LGNEDLTVKMSDRGGGVPLRKIDRLFNYMYSTAPRPRVETSRAVPLAGFGYGLPISRLYA 310 320 330 340 350 360 340 350 360 370 380 390 pF1KE3 KYFQGDLQLFSMEGFGTDAVIYLKALSTDSVERLPVYNKSAWRHYQTIQEAGDWCVPSTE .::::::.:.:.::.:::::::.:::::::.::::::::.::.::.: .:: :::::: : NP_002 QYFQGDLKLYSLEGYGTDAVIYIKALSTDSIERLPVYNKAAWKHYNTNHEADDWCVPSRE 370 380 390 400 410 420 400 pF1KE3 PKNTSTYRVS ::. .:.: NP_002 PKDMTTFRSA 430 >>NP_005382 (OMIM: 300906) pyruvate dehydrogenase kinase (406 aa) initn: 1852 init1: 1217 opt: 1876 Z-score: 2263.3 bits: 427.7 E(85289): 2.5e-119 Smith-Waterman score: 1876; 67.1% identity (87.5% similar) in 407 aa overlap (2-405:5-403) 10 20 30 40 50 pF1KE3 MRWVWALLKNASLAGAPKYIEHFSKFSPSPLSMKQFLDFGSSNACEKTSFTFLRQEL :: :::. .:: ::..:.:::::::.::::::: .:::::::. :::.:: NP_005 MRLFRW---LLKQP----VPKQIERYSRFSPSPLSIKQFLDFGRDNACEKTSYMFLRKEL 10 20 30 40 50 60 70 80 90 100 110 pF1KE3 PVRLANIMKEINLLPDRVLSTPSVQLVQSWYVQSLLDIMEFLDKDPEDHRTLSQFTDALV :::::: :.:.::::: .:. ::: ::::::.::.:...:. .:.::: ..:..: ..:. NP_005 PVRLANTMREVNLLPDNLLNRPSVGLVQSWYMQSFLELLEYENKSPEDPQVLDNFLQVLI 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE3 TIRNRHNDVVPTMAQGVLEYKDTYGDDPVSNQNIQYFLDRFYLSRISIRMLINQHTLIFD .:::::::::::::::.:::. .: :: . :::::::::: .:::.:::::::::.: NP_005 KVRNRHNDVVPTMAQGVIEYKEKFGFDPFISTNIQYFLDRFYTNRISFRMLINQHTLLFG 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE3 GSTNPAHPKHIGSIDPNCNVSEVVKDAYDMAKLLCDKYYMASPDLEIQEINAANSKQPIH :.:::.::::::::::.:::..::::::. ::.::..::...:.::..:.:: .::. NP_005 GDTNPVHPKHIGSIDPTCNVADVVKDAYETAKMLCEQYYLVAPELEVEEFNAKAPDKPIQ 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE3 MVYVPSHLYHMLFELFKNAMRATVESHES-SLILPPIKVMVALGEEDLSIKMSDRGGGVP .:::::::.:::::::::.:::::: .:. . : .:..:.::.::::::.:: ::::: NP_005 VVYVPSHLFHMLFELFKNSMRATVELYEDRKEGYPAVKTLVTLGKEDLSIKISDLGGGVP 240 250 260 270 280 290 300 310 320 330 340 350 pF1KE3 LRKIERLFSYMYSTAPTP--QPGTGGTPLAGFGYGLPISRLYAKYFQGDLQLFSMEGFGT ::::.:::.::::::: : .: : ..::::::::::::::::.::::::.:.:::: :: NP_005 LRKIDRLFNYMYSTAPRPSLEP-TRAAPLAGFGYGLPISRLYARYFQGDLKLYSMEGVGT 300 310 320 330 340 350 360 370 380 390 400 pF1KE3 DAVIYLKALSTDSVERLPVYNKSAWRHYQTIQEAGDWCVPSTEPKNTSTYRVS ::::::::::..: :::::.::::::::.: :: :: ::.::...: :. NP_005 DAVIYLKALSSESFERLPVFNKSAWRHYKTTPEADDWSNPSSEPRDASKYKAKQ 360 370 380 390 400 >>NP_001135858 (OMIM: 300906) pyruvate dehydrogenase kin (415 aa) initn: 1852 init1: 1217 opt: 1876 Z-score: 2263.2 bits: 427.7 E(85289): 2.5e-119 Smith-Waterman score: 1876; 67.1% identity (87.5% similar) in 407 aa overlap (2-405:5-403) 10 20 30 40 50 pF1KE3 MRWVWALLKNASLAGAPKYIEHFSKFSPSPLSMKQFLDFGSSNACEKTSFTFLRQEL :: :::. .:: ::..:.:::::::.::::::: .:::::::. :::.:: NP_001 MRLFRW---LLKQP----VPKQIERYSRFSPSPLSIKQFLDFGRDNACEKTSYMFLRKEL 10 20 30 40 50 60 70 80 90 100 110 pF1KE3 PVRLANIMKEINLLPDRVLSTPSVQLVQSWYVQSLLDIMEFLDKDPEDHRTLSQFTDALV :::::: :.:.::::: .:. ::: ::::::.::.:...:. .:.::: ..:..: ..:. NP_001 PVRLANTMREVNLLPDNLLNRPSVGLVQSWYMQSFLELLEYENKSPEDPQVLDNFLQVLI 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE3 TIRNRHNDVVPTMAQGVLEYKDTYGDDPVSNQNIQYFLDRFYLSRISIRMLINQHTLIFD .:::::::::::::::.:::. .: :: . :::::::::: .:::.:::::::::.: NP_001 KVRNRHNDVVPTMAQGVIEYKEKFGFDPFISTNIQYFLDRFYTNRISFRMLINQHTLLFG 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE3 GSTNPAHPKHIGSIDPNCNVSEVVKDAYDMAKLLCDKYYMASPDLEIQEINAANSKQPIH :.:::.::::::::::.:::..::::::. ::.::..::...:.::..:.:: .::. NP_001 GDTNPVHPKHIGSIDPTCNVADVVKDAYETAKMLCEQYYLVAPELEVEEFNAKAPDKPIQ 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE3 MVYVPSHLYHMLFELFKNAMRATVESHES-SLILPPIKVMVALGEEDLSIKMSDRGGGVP .:::::::.:::::::::.:::::: .:. . : .:..:.::.::::::.:: ::::: NP_001 VVYVPSHLFHMLFELFKNSMRATVELYEDRKEGYPAVKTLVTLGKEDLSIKISDLGGGVP 240 250 260 270 280 290 300 310 320 330 340 350 pF1KE3 LRKIERLFSYMYSTAPTP--QPGTGGTPLAGFGYGLPISRLYAKYFQGDLQLFSMEGFGT ::::.:::.::::::: : .: : ..::::::::::::::::.::::::.:.:::: :: NP_001 LRKIDRLFNYMYSTAPRPSLEP-TRAAPLAGFGYGLPISRLYARYFQGDLKLYSMEGVGT 300 310 320 330 340 350 360 370 380 390 400 pF1KE3 DAVIYLKALSTDSVERLPVYNKSAWRHYQTIQEAGDWCVPSTEPKNTSTYRVS ::::::::::..: :::::.::::::::.: :: :: ::.::...: :. NP_001 DAVIYLKALSSESFERLPVFNKSAWRHYKTTPEADDWSNPSSEPRDASKYKAKQDKIKTN 360 370 380 390 400 410 NP_001 RTF >>NP_002603 (OMIM: 602527) pyruvate dehydrogenase kinase (411 aa) initn: 1109 init1: 1109 opt: 1850 Z-score: 2231.9 bits: 421.9 E(85289): 1.4e-117 Smith-Waterman score: 1850; 65.2% identity (89.1% similar) in 405 aa overlap (1-400:1-404) 10 20 30 40 50 pF1KE3 MRWVWALLKNA-SLAGA---PKYIEHFSKFSPSPLSMKQFLDFGSSNACEKTSFTFLRQE :. . .:..: :: :: :. .::::..:::::::::.::::: ::::.:::.::::: NP_002 MKAARFVLRSAGSLNGAGLVPREVEHFSRYSPSPLSMKQLLDFGSENACERTSFAFLRQE 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE3 LPVRLANIMKEINLLPDRVLSTPSVQLVQSWYVQSLLDIMEFLDKDPEDHRTLSQFTDAL ::::::::.:::..:: ....: :::::.:::.:::.:..:: .:.:.:...::.:.:.: NP_002 LPVRLANILKEIDILPTQLVNTSSVQLVKSWYIQSLMDLVEFHEKSPDDQKALSDFVDTL 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE3 VTIRNRHNDVVPTMAQGVLEYKDTYGDDPVSNQNIQYFLDRFYLSRISIRMLINQHTLIF . .::::..::::::::..::::. :::.:::.::::::::..::: :::.::: ::: NP_002 IKVRNRHHNVVPTMAQGIIEYKDACTVDPVTNQNLQYFLDRFYMNRISTRMLMNQHILIF 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE3 DGSTNPAHPKHIGSIDPNCNVSEVVKDAYDMAKLLCDKYYMASPDLEIQEINAANSKQPI . : . ..:.:::::::::.: ::.::.. ...:::.::..::.:.. ..:. ::: NP_002 SDSQT-GNPSHIGSIDPNCDVVAVVQDAFECSRMLCDQYYLSSPELKLTQVNGKFPDQPI 190 200 210 220 230 240 250 260 270 280 290 pF1KE3 HMVYVPSHLYHMLFELFKNAMRATVESHESSLILPPIKVMVALGEEDLSIKMSDRGGGVP :.:::::::.:::::::::::::::: .:.. : ::.:.:.::.:::.::.:::::::: NP_002 HIVYVPSHLHHMLFELFKNAMRATVEHQENQPSLTPIEVIVVLGKEDLTIKISDRGGGVP 240 250 260 270 280 290 300 310 320 330 340 350 pF1KE3 LRKIERLFSYMYSTAPTP-QPGTGGTPLAGFGYGLPISRLYAKYFQGDLQLFSMEGFGTD :: :.::::: ::::::: . .. ..:::::::::::::::::::::::.:.:. :.::: NP_002 LRIIDRLFSYTYSTAPTPVMDNSRNAPLAGFGYGLPISRLYAKYFQGDLNLYSLSGYGTD 300 310 320 330 340 350 360 370 380 390 400 pF1KE3 AVIYLKALSTDSVERLPVYNKSAWRHYQTIQEAGDWCVPSTEPKNTSTYRVS :.:::::::..:.:.:::.::::..::: .:: :::.:: :::: NP_002 AIIYLKALSSESIEKLPVFNKSAFKHYQMSSEADDWCIPSREPKNLAKEVAM 360 370 380 390 400 410 >>XP_011509647 (OMIM: 602524) PREDICTED: pyruvate dehydr (360 aa) initn: 1746 init1: 645 opt: 1764 Z-score: 2129.0 bits: 402.7 E(85289): 7.5e-112 Smith-Waterman score: 1764; 69.7% identity (89.9% similar) in 357 aa overlap (52-405:2-358) 30 40 50 60 70 80 pF1KE3 HFSKFSPSPLSMKQFLDFGSSNACEKTSFTFLRQELPVRLANIMKEINLLPDRVLSTPSV :::::::::::::::::.:::: .: :::: XP_011 MFLRQELPVRLANIMKEISLLPDNLLRTPSV 10 20 30 90 100 110 120 130 140 pF1KE3 QLVQSWYVQSLLDIMEFLDKDPEDHRTLSQFTDALVTIRNRHNDVVPTMAQGVLEYKDTY :::::::.::: ....: ::. :: ... .:::... ::::::::.:::::::.:::... XP_011 QLVQSWYIQSLQELLDFKDKSAEDAKAIYDFTDTVIRIRNRHNDVIPTMAQGVIEYKESF 40 50 60 70 80 90 150 160 170 180 190 pF1KE3 GDDPVSNQNIQYFLDRFYLSRISIRMLINQHTLIFDGST--NPAHPKHIGSIDPNCNVSE : :::..::.::::::::.::::::::.:::.:.: :. .:.: ::::::.::::: : XP_011 GVDPVTSQNVQYFLDRFYMSRISIRMLLNQHSLLFGGKGKGSPSHRKHIGSINPNCNVLE 100 110 120 130 140 150 200 210 220 230 240 250 pF1KE3 VVKDAYDMAKLLCDKYYMASPDLEIQEINAANSKQPIHMVYVPSHLYHMLFELFKNAMRA :.::.:. :. ::: ::. ::.::..:.:: . :::..::::::::::.:::::::::: XP_011 VIKDGYENARRLCDLYYINSPELELEELNAKSPGQPIQVVYVPSHLYHMVFELFKNAMRA 160 170 180 190 200 210 260 270 280 290 300 310 pF1KE3 TVESHESSLILPPIKVMVALGEEDLSIKMSDRGGGVPLRKIERLFSYMYSTAPTPQPGTG :.: : . . :::.: :.::.:::..::::::::::::::.:::.::::::: :. :. XP_011 TMEHHANRGVYPPIQVHVTLGNEDLTVKMSDRGGGVPLRKIDRLFNYMYSTAPRPRVETS 220 230 240 250 260 270 320 330 340 350 360 370 pF1KE3 -GTPLAGFGYGLPISRLYAKYFQGDLQLFSMEGFGTDAVIYLKALSTDSVERLPVYNKSA ..::::::::::::::::.::::::.:.:.::.:::::::.:::::::.::::::::.: XP_011 RAVPLAGFGYGLPISRLYAQYFQGDLKLYSLEGYGTDAVIYIKALSTDSIERLPVYNKAA 280 290 300 310 320 330 380 390 400 pF1KE3 WRHYQTIQEAGDWCVPSTEPKNTSTYRVS :.::.: .:: :::::: :::. .:.: XP_011 WKHYNTNHEADDWCVPSREPKDMTTFRSA 340 350 360 >>XP_011509649 (OMIM: 602524) PREDICTED: pyruvate dehydr (380 aa) initn: 1734 init1: 642 opt: 1487 Z-score: 1794.7 bits: 340.9 E(85289): 3.2e-93 Smith-Waterman score: 1717; 66.8% identity (85.1% similar) in 377 aa overlap (52-405:2-378) 30 40 50 60 70 80 pF1KE3 HFSKFSPSPLSMKQFLDFGSSNACEKTSFTFLRQELPVRLANIMKEINLLPDRVLSTPSV :::::::::::::::::.:::: .: :::: XP_011 MFLRQELPVRLANIMKEISLLPDNLLRTPSV 10 20 30 90 100 110 120 pF1KE3 QLVQSWYVQSLLDIMEFLDKDPED--------HRTLSQ------------FTDALVTIRN :::::::.::: ....: ::. :: .:: : :::... ::: XP_011 QLVQSWYIQSLQELLDFKDKSAEDAKAIYERPRRTWLQVSSLCCMACKMIFTDTVIRIRN 40 50 60 70 80 90 130 140 150 160 170 180 pF1KE3 RHNDVVPTMAQGVLEYKDTYGDDPVSNQNIQYFLDRFYLSRISIRMLINQHTLIFDGST- :::::.:::::::.:::...: :::..::.::::::::.::::::::.:::.:.: :. XP_011 RHNDVIPTMAQGVIEYKESFGVDPVTSQNVQYFLDRFYMSRISIRMLLNQHSLLFGGKGK 100 110 120 130 140 150 190 200 210 220 230 pF1KE3 -NPAHPKHIGSIDPNCNVSEVVKDAYDMAKLLCDKYYMASPDLEIQEINAANSKQPIHMV .:.: ::::::.::::: ::.::.:. :. ::: ::. ::.::..:.:: . :::..: XP_011 GSPSHRKHIGSINPNCNVLEVIKDGYENARRLCDLYYINSPELELEELNAKSPGQPIQVV 160 170 180 190 200 210 240 250 260 270 280 290 pF1KE3 YVPSHLYHMLFELFKNAMRATVESHESSLILPPIKVMVALGEEDLSIKMSDRGGGVPLRK :::::::::.:::::::::::.: : . . :::.: :.::.:::..::::::::::::: XP_011 YVPSHLYHMVFELFKNAMRATMEHHANRGVYPPIQVHVTLGNEDLTVKMSDRGGGVPLRK 220 230 240 250 260 270 300 310 320 330 340 350 pF1KE3 IERLFSYMYSTAPTPQPGTG-GTPLAGFGYGLPISRLYAKYFQGDLQLFSMEGFGTDAVI :.:::.::::::: :. :. ..::::::::::::::::.::::::.:.:.::.:::::: XP_011 IDRLFNYMYSTAPRPRVETSRAVPLAGFGYGLPISRLYAQYFQGDLKLYSLEGYGTDAVI 280 290 300 310 320 330 360 370 380 390 400 pF1KE3 YLKALSTDSVERLPVYNKSAWRHYQTIQEAGDWCVPSTEPKNTSTYRVS :.:::::::.::::::::.::.::.: .:: :::::: :::. .:.: XP_011 YIKALSTDSIERLPVYNKAAWKHYNTNHEADDWCVPSREPKDMTTFRSA 340 350 360 370 380 >>XP_011509645 (OMIM: 602524) PREDICTED: pyruvate dehydr (380 aa) initn: 1734 init1: 642 opt: 1487 Z-score: 1794.7 bits: 340.9 E(85289): 3.2e-93 Smith-Waterman score: 1717; 66.8% identity (85.1% similar) in 377 aa overlap (52-405:2-378) 30 40 50 60 70 80 pF1KE3 HFSKFSPSPLSMKQFLDFGSSNACEKTSFTFLRQELPVRLANIMKEINLLPDRVLSTPSV :::::::::::::::::.:::: .: :::: XP_011 MFLRQELPVRLANIMKEISLLPDNLLRTPSV 10 20 30 90 100 110 120 pF1KE3 QLVQSWYVQSLLDIMEFLDKDPED--------HRTLSQ------------FTDALVTIRN :::::::.::: ....: ::. :: .:: : :::... ::: XP_011 QLVQSWYIQSLQELLDFKDKSAEDAKAIYERPRRTWLQVSSLCCMACKMIFTDTVIRIRN 40 50 60 70 80 90 130 140 150 160 170 180 pF1KE3 RHNDVVPTMAQGVLEYKDTYGDDPVSNQNIQYFLDRFYLSRISIRMLINQHTLIFDGST- :::::.:::::::.:::...: :::..::.::::::::.::::::::.:::.:.: :. XP_011 RHNDVIPTMAQGVIEYKESFGVDPVTSQNVQYFLDRFYMSRISIRMLLNQHSLLFGGKGK 100 110 120 130 140 150 190 200 210 220 230 pF1KE3 -NPAHPKHIGSIDPNCNVSEVVKDAYDMAKLLCDKYYMASPDLEIQEINAANSKQPIHMV .:.: ::::::.::::: ::.::.:. :. ::: ::. ::.::..:.:: . :::..: XP_011 GSPSHRKHIGSINPNCNVLEVIKDGYENARRLCDLYYINSPELELEELNAKSPGQPIQVV 160 170 180 190 200 210 240 250 260 270 280 290 pF1KE3 YVPSHLYHMLFELFKNAMRATVESHESSLILPPIKVMVALGEEDLSIKMSDRGGGVPLRK :::::::::.:::::::::::.: : . . :::.: :.::.:::..::::::::::::: XP_011 YVPSHLYHMVFELFKNAMRATMEHHANRGVYPPIQVHVTLGNEDLTVKMSDRGGGVPLRK 220 230 240 250 260 270 300 310 320 330 340 350 pF1KE3 IERLFSYMYSTAPTPQPGTG-GTPLAGFGYGLPISRLYAKYFQGDLQLFSMEGFGTDAVI :.:::.::::::: :. :. ..::::::::::::::::.::::::.:.:.::.:::::: XP_011 IDRLFNYMYSTAPRPRVETSRAVPLAGFGYGLPISRLYAQYFQGDLKLYSLEGYGTDAVI 280 290 300 310 320 330 360 370 380 390 400 pF1KE3 YLKALSTDSVERLPVYNKSAWRHYQTIQEAGDWCVPSTEPKNTSTYRVS :.:::::::.::::::::.::.::.: .:: :::::: :::. .:.: XP_011 YIKALSTDSIERLPVYNKAAWKHYNTNHEADDWCVPSREPKDMTTFRSA 340 350 360 370 380 407 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 06:38:08 2016 done: Sun Nov 6 06:38:09 2016 Total Scan time: 7.520 Total Display time: 0.050 Function used was FASTA [36.3.4 Apr, 2011]