FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE1840, 357 aa 1>>>pF1KE1840 357 - 357 aa - 357 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.2432+/-0.00033; mu= 17.5929+/- 0.021 mean_var=79.2816+/-15.456, 0's: 0 Z-trim(117.1): 64 B-trim: 147 in 2/53 Lambda= 0.144042 statistics sampled from 28672 (28741) to 28672 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.71), E-opt: 0.2 (0.337), width: 16 Scan time: 7.560 The best scores are: opt bits E(85289) NP_003387 (OMIM: 602864) protein Wnt-9b isoform 1 ( 357) 2492 527.2 2.2e-149 XP_011523480 (OMIM: 602864) PREDICTED: protein Wnt ( 363) 2318 491.0 1.7e-138 NP_001307387 (OMIM: 602864) protein Wnt-9b isoform ( 329) 2063 438.0 1.4e-122 NP_003386 (OMIM: 602863) protein Wnt-9a precursor ( 365) 1540 329.3 8.1e-90 XP_011542573 (OMIM: 602863) PREDICTED: protein Wnt ( 295) 1400 300.2 3.9e-81 NP_110388 (OMIM: 158330,603490,611812) protein Wnt ( 351) 837 183.2 7.4e-46 XP_011539899 (OMIM: 158330,603490,611812) PREDICTE ( 373) 837 183.3 7.8e-46 NP_005421 (OMIM: 164820,615220,615221) proto-oncog ( 370) 833 182.4 1.4e-45 NP_478679 (OMIM: 601967) protein Wnt-7b precursor ( 349) 828 181.4 2.7e-45 NP_004616 (OMIM: 228930,276820,601570) protein Wnt ( 349) 824 180.5 4.8e-45 XP_011528668 (OMIM: 601967) PREDICTED: protein Wnt ( 353) 823 180.3 5.6e-45 XP_011539900 (OMIM: 158330,603490,611812) PREDICTE ( 296) 805 176.5 6.6e-44 XP_011532393 (OMIM: 228930,276820,601570) PREDICTE ( 282) 783 171.9 1.5e-42 NP_004617 (OMIM: 603699) protein Wnt-11 precursor ( 354) 745 164.1 4.3e-40 XP_005274288 (OMIM: 603699) PREDICTED: protein Wnt ( 354) 745 164.1 4.3e-40 NP_110380 (OMIM: 165330,273395) proto-oncogene Wnt ( 355) 726 160.2 6.6e-39 NP_003384 (OMIM: 601396) protein Wnt-8b precursor ( 351) 715 157.9 3.2e-38 NP_149122 (OMIM: 606359) protein Wnt-3a precursor ( 352) 714 157.7 3.7e-38 XP_011542621 (OMIM: 606359) PREDICTED: protein Wnt ( 446) 714 157.8 4.4e-38 NP_057171 (OMIM: 606267) protein Wnt-16 isoform 2 ( 355) 699 154.6 3.2e-37 NP_476509 (OMIM: 606267) protein Wnt-16 isoform 1 ( 365) 699 154.6 3.3e-37 NP_001278809 (OMIM: 601968) protein Wnt-2b isoform ( 299) 660 146.4 7.8e-35 NP_004176 (OMIM: 601968) protein Wnt-2b isoform WN ( 372) 660 146.5 9.2e-35 NP_078613 (OMIM: 601968) protein Wnt-2b isoform WN ( 391) 660 146.5 9.5e-35 XP_011543541 (OMIM: 603699) PREDICTED: protein Wnt ( 364) 655 145.4 1.9e-34 XP_011543540 (OMIM: 603699) PREDICTED: protein Wnt ( 364) 655 145.4 1.9e-34 XP_011543542 (OMIM: 603699) PREDICTED: protein Wnt ( 364) 655 145.4 1.9e-34 XP_016873730 (OMIM: 603699) PREDICTED: protein Wnt ( 251) 650 144.3 2.9e-34 XP_011543543 (OMIM: 603699) PREDICTED: protein Wnt ( 251) 650 144.3 2.9e-34 NP_003382 (OMIM: 147870) protein Wnt-2 precursor [ ( 360) 642 142.7 1.2e-33 NP_490645 (OMIM: 606360) protein Wnt-8a isoform 3 ( 351) 596 133.1 8.9e-31 NP_001287868 (OMIM: 606360) protein Wnt-8a isoform ( 369) 596 133.2 9.2e-31 NP_001287867 (OMIM: 606360) protein Wnt-8a isoform ( 386) 596 133.2 9.5e-31 XP_016865314 (OMIM: 606360) PREDICTED: protein Wnt ( 391) 596 133.2 9.6e-31 XP_016865313 (OMIM: 606360) PREDICTED: protein Wnt ( 408) 596 133.2 9.9e-31 XP_011541927 (OMIM: 606360) PREDICTED: protein Wnt ( 337) 590 131.9 2e-30 XP_011537024 (OMIM: 225300,601906,617073) PREDICTE ( 267) 520 117.3 4.1e-26 XP_016875408 (OMIM: 225300,601906,617073) PREDICTE ( 267) 520 117.3 4.1e-26 NP_003385 (OMIM: 225300,601906,617073) protein Wnt ( 389) 520 117.4 5.4e-26 NP_006513 (OMIM: 604663) protein Wnt-6 precursor [ ( 365) 510 115.3 2.2e-25 NP_116031 (OMIM: 606361) protein Wnt-5b precursor ( 359) 482 109.5 1.2e-23 NP_110402 (OMIM: 606361) protein Wnt-5b precursor ( 359) 482 109.5 1.2e-23 XP_016862617 (OMIM: 164975,180700) PREDICTED: prot ( 365) 480 109.1 1.6e-23 XP_006713387 (OMIM: 164975,180700) PREDICTED: prot ( 365) 480 109.1 1.6e-23 XP_011532391 (OMIM: 164975,180700) PREDICTED: prot ( 365) 480 109.1 1.6e-23 XP_011532390 (OMIM: 164975,180700) PREDICTED: prot ( 365) 480 109.1 1.6e-23 XP_011532389 (OMIM: 164975,180700) PREDICTED: prot ( 365) 480 109.1 1.6e-23 XP_011532387 (OMIM: 164975,180700) PREDICTED: prot ( 365) 480 109.1 1.6e-23 NP_001243034 (OMIM: 164975,180700) protein Wnt-5a ( 365) 480 109.1 1.6e-23 XP_011532388 (OMIM: 164975,180700) PREDICTED: prot ( 365) 480 109.1 1.6e-23 >>NP_003387 (OMIM: 602864) protein Wnt-9b isoform 1 prec (357 aa) initn: 2492 init1: 2492 opt: 2492 Z-score: 2802.8 bits: 527.2 E(85289): 2.2e-149 Smith-Waterman score: 2492; 99.7% identity (99.7% similar) in 357 aa overlap (1-357:1-357) 10 20 30 40 50 60 pF1KE1 MRPPPALALAGLCLLALPAAAASYFGLTGREVLTPFPGLGTAAAPAQGGAHLKQCDLLKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 MRPPPALALAGLCLLALPAAAASYFGLTGREVLTPFPGLGTAAAPAQGGAHLKQCDLLKL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 SRRQKQLCRREPGLAETLRDAAHLGLLECQFQFRHERWNCSLEGRTGLLKRGFKETAFLY ::::::::::::::::::::::::::::::::::::::::::::: :::::::::::::: NP_003 SRRQKQLCRREPGLAETLRDAAHLGLLECQFQFRHERWNCSLEGRMGLLKRGFKETAFLY 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 AVSSAALTHTLARACSAGRMERCTCDDSPGLESRQAWQWGVCGDNLKYSTKFLSNFLGSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 AVSSAALTHTLARACSAGRMERCTCDDSPGLESRQAWQWGVCGDNLKYSTKFLSNFLGSK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 RGNKDLRARADAHNTHVGIKAVKSGLRTTCKCHGVSGSCAVRTCWKQLSPFRETGQVLKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 RGNKDLRARADAHNTHVGIKAVKSGLRTTCKCHGVSGSCAVRTCWKQLSPFRETGQVLKL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 RYDSAVKVSSATNEALGRLELWAPARQGSLTKGLAPRSGDLVYMEDSPSFCRPSKYSPGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 RYDSAVKVSSATNEALGRLELWAPARQGSLTKGLAPRSGDLVYMEDSPSFCRPSKYSPGT 250 260 270 280 290 300 310 320 330 340 350 pF1KE1 AGRVCSREASCSSLCCGRGYDTQSRLVAFSCHCQVQWCCYVECQQCVQEELVYTCKH ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 AGRVCSREASCSSLCCGRGYDTQSRLVAFSCHCQVQWCCYVECQQCVQEELVYTCKH 310 320 330 340 350 >>XP_011523480 (OMIM: 602864) PREDICTED: protein Wnt-9b (363 aa) initn: 2318 init1: 2318 opt: 2318 Z-score: 2607.3 bits: 491.0 E(85289): 1.7e-138 Smith-Waterman score: 2318; 99.7% identity (99.7% similar) in 331 aa overlap (27-357:33-363) 10 20 30 40 50 pF1KE1 MRPPPALALAGLCLLALPAAAASYFGLTGREVLTPFPGLGTAAAPAQGGAHLKQCD :::::::::::::::::::::::::::::: XP_011 GRAVSFDPLACQGLNASPGSLTSPLRRIRSLTGREVLTPFPGLGTAAAPAQGGAHLKQCD 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE1 LLKLSRRQKQLCRREPGLAETLRDAAHLGLLECQFQFRHERWNCSLEGRTGLLKRGFKET ::::::::::::::::::::::::::::::::::::::::::::::::: :::::::::: XP_011 LLKLSRRQKQLCRREPGLAETLRDAAHLGLLECQFQFRHERWNCSLEGRMGLLKRGFKET 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE1 AFLYAVSSAALTHTLARACSAGRMERCTCDDSPGLESRQAWQWGVCGDNLKYSTKFLSNF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AFLYAVSSAALTHTLARACSAGRMERCTCDDSPGLESRQAWQWGVCGDNLKYSTKFLSNF 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE1 LGSKRGNKDLRARADAHNTHVGIKAVKSGLRTTCKCHGVSGSCAVRTCWKQLSPFRETGQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LGSKRGNKDLRARADAHNTHVGIKAVKSGLRTTCKCHGVSGSCAVRTCWKQLSPFRETGQ 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE1 VLKLRYDSAVKVSSATNEALGRLELWAPARQGSLTKGLAPRSGDLVYMEDSPSFCRPSKY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VLKLRYDSAVKVSSATNEALGRLELWAPARQGSLTKGLAPRSGDLVYMEDSPSFCRPSKY 250 260 270 280 290 300 300 310 320 330 340 350 pF1KE1 SPGTAGRVCSREASCSSLCCGRGYDTQSRLVAFSCHCQVQWCCYVECQQCVQEELVYTCK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SPGTAGRVCSREASCSSLCCGRGYDTQSRLVAFSCHCQVQWCCYVECQQCVQEELVYTCK 310 320 330 340 350 360 pF1KE1 H : XP_011 H >>NP_001307387 (OMIM: 602864) protein Wnt-9b isoform 2 p (329 aa) initn: 2063 init1: 2063 opt: 2063 Z-score: 2321.5 bits: 438.0 E(85289): 1.4e-122 Smith-Waterman score: 2063; 99.7% identity (99.7% similar) in 302 aa overlap (1-302:1-302) 10 20 30 40 50 60 pF1KE1 MRPPPALALAGLCLLALPAAAASYFGLTGREVLTPFPGLGTAAAPAQGGAHLKQCDLLKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MRPPPALALAGLCLLALPAAAASYFGLTGREVLTPFPGLGTAAAPAQGGAHLKQCDLLKL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 SRRQKQLCRREPGLAETLRDAAHLGLLECQFQFRHERWNCSLEGRTGLLKRGFKETAFLY ::::::::::::::::::::::::::::::::::::::::::::: :::::::::::::: NP_001 SRRQKQLCRREPGLAETLRDAAHLGLLECQFQFRHERWNCSLEGRMGLLKRGFKETAFLY 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 AVSSAALTHTLARACSAGRMERCTCDDSPGLESRQAWQWGVCGDNLKYSTKFLSNFLGSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AVSSAALTHTLARACSAGRMERCTCDDSPGLESRQAWQWGVCGDNLKYSTKFLSNFLGSK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 RGNKDLRARADAHNTHVGIKAVKSGLRTTCKCHGVSGSCAVRTCWKQLSPFRETGQVLKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RGNKDLRARADAHNTHVGIKAVKSGLRTTCKCHGVSGSCAVRTCWKQLSPFRETGQVLKL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 RYDSAVKVSSATNEALGRLELWAPARQGSLTKGLAPRSGDLVYMEDSPSFCRPSKYSPGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RYDSAVKVSSATNEALGRLELWAPARQGSLTKGLAPRSGDLVYMEDSPSFCRPSKYSPGT 250 260 270 280 290 300 310 320 330 340 350 pF1KE1 AGRVCSREASCSSLCCGRGYDTQSRLVAFSCHCQVQWCCYVECQQCVQEELVYTCKH :: NP_001 AGWSAVARSQLITTSTSRIQAILPSQLPE 310 320 >>NP_003386 (OMIM: 602863) protein Wnt-9a precursor [Hom (365 aa) initn: 1223 init1: 453 opt: 1540 Z-score: 1733.5 bits: 329.3 E(85289): 8.1e-90 Smith-Waterman score: 1540; 61.2% identity (82.9% similar) in 356 aa overlap (6-356:12-364) 10 20 30 40 50 pF1KE1 MRPPPALALAGLCLLALPAAAASYFGLTGREVLTPFPGLGTAAAPAQGGAHLKQ : :.. ::: .:.:::::: : :: .: : :: :: : NP_003 MLDGSPLARWLAAAFGLTLLLAALRPSAAYFGLTGSEPLTILPLTLEPEAAAQ--AHYKA 10 20 30 40 50 60 70 80 90 100 110 pF1KE1 CDLLKLSRRQKQLCRREPGLAETLRDAAHLGLLECQFQFRHERWNCSLEGR--TGLLKRG :: ::: :.:...:::.::.:::: .:. .. :::::::: :::::.:::: ..::::: NP_003 CDRLKLERKQRRMCRRDPGVAETLVEAVSMSALECQFQFRFERWNCTLEGRYRASLLKRG 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE1 FKETAFLYAVSSAALTHTLARACSAGRMERCTCDDSPGLESRQAWQWGVCGDNLKYSTKF :::::::::.:::.:::.::.:::::::::::::..: ::.:.::::: ::::::::.:: NP_003 FKETAFLYAISSAGLTHALAKACSAGRMERCTCDEAPDLENREAWQWGGCGDNLKYSSKF 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE1 LSNFLGSKRGNKDLRARADAHNTHVGIKAVKSGLRTTCKCHGVSGSCAVRTCWKQLSPFR ...::: .:..::::::.: ::. ::.:..:.:..::::::::::::.:::::.::.::. NP_003 VKEFLG-RRSSKDLRARVDFHNNLVGVKVIKAGVETTCKCHGVSGSCTVRTCWRQLAPFH 180 190 200 210 220 230 240 250 260 270 280 pF1KE1 ETGQVLKLRYDSAVKVSSATNEALGRLELWAPAR---QGSLTKGLAPRSGDLVYMEDSPS :.:. :: .:..:.::.:.:::: :. .: : .:. . ::. .::...:::: NP_003 EVGKHLKHKYETALKVGSTTNEAAGEAGAISPPRGRASGAGGSDPLPRTPELVHLDDSPS 240 250 260 270 280 290 290 300 310 320 330 340 pF1KE1 FCRPSKYSPGTAGRVCSREASCSSLCCGRGYDTQSRLVAFSCHCQVQWCCYVECQQCVQE :: ...::::::: : :: .: :.:::::..::::.:. :.:::.:::::::.::.:. NP_003 FCLAGRFSPGTAGRRCHREKNCESICCGRGHNTQSRVVTRPCQCQVRWCCYVECRQCTQR 300 310 320 330 340 350 350 pF1KE1 ELVYTCKH : ::::: NP_003 EEVYTCKG 360 >>XP_011542573 (OMIM: 602863) PREDICTED: protein Wnt-9a (295 aa) initn: 1202 init1: 437 opt: 1400 Z-score: 1577.6 bits: 300.2 E(85289): 3.9e-81 Smith-Waterman score: 1400; 64.1% identity (87.5% similar) in 295 aa overlap (67-356:1-294) 40 50 60 70 80 90 pF1KE1 PGLGTAAAPAQGGAHLKQCDLLKLSRRQKQLCRREPGLAETLRDAAHLGLLECQFQFRHE .:::.::.:::: .:. .. :::::::: : XP_011 MCRRDPGVAETLVEAVSMSALECQFQFRFE 10 20 30 100 110 120 130 140 150 pF1KE1 RWNCSLEGR--TGLLKRGFKETAFLYAVSSAALTHTLARACSAGRMERCTCDDSPGLESR ::::.:::: ..::::::::::::::.:::.:::.::.:::::::::::::..: ::.: XP_011 RWNCTLEGRYRASLLKRGFKETAFLYAISSAGLTHALAKACSAGRMERCTCDEAPDLENR 40 50 60 70 80 90 160 170 180 190 200 210 pF1KE1 QAWQWGVCGDNLKYSTKFLSNFLGSKRGNKDLRARADAHNTHVGIKAVKSGLRTTCKCHG .::::: ::::::::.::...::: .:..::::::.: ::. ::.:..:.:..::::::: XP_011 EAWQWGGCGDNLKYSSKFVKEFLG-RRSSKDLRARVDFHNNLVGVKVIKAGVETTCKCHG 100 110 120 130 140 220 230 240 250 260 270 pF1KE1 VSGSCAVRTCWKQLSPFRETGQVLKLRYDSAVKVSSATNEALGRLELWAPAR---QGSLT :::::.:::::.::.::.:.:. :: .:..:.::.:.:::: :. .: : .:. XP_011 VSGSCTVRTCWRQLAPFHEVGKHLKHKYETALKVGSTTNEAAGEAGAISPPRGRASGAGG 150 160 170 180 190 200 280 290 300 310 320 330 pF1KE1 KGLAPRSGDLVYMEDSPSFCRPSKYSPGTAGRVCSREASCSSLCCGRGYDTQSRLVAFSC . ::. .::...:::::: ...::::::: : :: .: :.:::::..::::.:. : XP_011 SDPLPRTPELVHLDDSPSFCLAGRFSPGTAGRRCHREKNCESICCGRGHNTQSRVVTRPC 210 220 230 240 250 260 340 350 pF1KE1 HCQVQWCCYVECQQCVQEELVYTCKH .:::.:::::::.::.:.: ::::: XP_011 QCQVRWCCYVECRQCTQREEVYTCKG 270 280 290 >>NP_110388 (OMIM: 158330,603490,611812) protein Wnt-4 p (351 aa) initn: 569 init1: 255 opt: 837 Z-score: 944.2 bits: 183.2 E(85289): 7.4e-46 Smith-Waterman score: 846; 38.9% identity (68.2% similar) in 324 aa overlap (55-356:43-351) 30 40 50 60 70 80 pF1KE1 FGLTGREVLTPFPGLGTAAAPAQGGAHLKQCDLLK-LSRRQKQLCRREPGLAETLRDAAH :. :: : .:: :.:.:. . ...: .:. NP_110 LVFAVFSAAASNWLYLAKLSSVGSISEEETCEKLKGLIQRQVQMCKRNLEVMDSVRRGAQ 20 30 40 50 60 70 90 100 110 120 130 pF1KE1 LGLLECQFQFRHERWNCS----LEGRTGLLKRGFKETAFLYAVSSAALTHTLARACSAGR :.. :::.:::..::::: : .. .: .:.::.::.:::... ...::::.:. NP_110 LAIEECQYQFRNRRWNCSTLDSLPVFGKVVTQGTREAAFVYAISSAGVAFAVTRACSSGE 80 90 100 110 120 130 140 150 160 170 180 190 pF1KE1 MERCTCDDSPGLESRQAWQWGVCGDNLKYSTKFLSNFLGSK---RGNKDLRARADAHNTH .:.: :: . : :..::. :.::. :.. : ..:. . .: .. :: . ::.. NP_110 LEKCGCDRTVHGVSPQGFQWSGCSDNIAYGVAFSQSFVDVRERSKGASSSRALMNLHNNE 140 150 160 170 180 190 200 210 220 230 240 250 pF1KE1 VGIKAVKSGLRTTCKCHGVSGSCAVRTCWKQLSPFRETGQVLKLRYDSAVKVSSATNEAL .: ::. . .:. :::::::::: :.:::. . :::..:..:: ..:.:..: NP_110 AGRKAILTHMRVECKCHGVSGSCEVKTCWRAVPPFRQVGHALKEKFDGATEVE------- 200 210 220 230 240 260 270 280 290 300 pF1KE1 GRLELWAPARQGSLTKGLAPRSG--------DLVYMEDSPSFCRPSKYSP--GTAGRVCS : : :: ...:.::.. ::::.: ::.::. . : :: ::.:. NP_110 -------PRRVGS-SRALVPRNAQFKPHTDEDLVYLEPSPDFCEQDMRSGVLGTRGRTCN 250 260 270 280 290 310 320 330 340 350 pF1KE1 REAS----CSSLCCGRGYDTQSRLVAFSCHCQVQWCCYVECQQCVQEELVYTCKH . .. : ::::::. : . .: : :. .:::.:.:.:: . ..::. NP_110 KTSKAIDGCELLCCGRGFHTAQVELAERCSCKFHWCCFVKCRQCQRLVELHTCR 300 310 320 330 340 350 >>XP_011539899 (OMIM: 158330,603490,611812) PREDICTED: p (373 aa) initn: 604 init1: 255 opt: 837 Z-score: 943.9 bits: 183.3 E(85289): 7.8e-46 Smith-Waterman score: 866; 35.9% identity (64.9% similar) in 382 aa overlap (3-356:8-373) 10 20 30 40 pF1KE1 MRPPPALALAGLCLLA------LPAAAASYFGLTGREVLTPFPGLGTAAAPAQGG :::: . ..:: :: . . : :... .: . . . . XP_011 MTQLTPAPPPASSQGSLCSTQGKRNKRLPRTLPNQRGYEGEDT-GHIPRYLAKLSSVGSI 10 20 30 40 50 50 60 70 80 90 100 pF1KE1 AHLKQCDLLK-LSRRQKQLCRREPGLAETLRDAAHLGLLECQFQFRHERWNCS----LEG .. . :. :: : .:: :.:.:. . ...: .:.:.. :::.:::..::::: : XP_011 SEEETCEKLKGLIQRQVQMCKRNLEVMDSVRRGAQLAIEECQYQFRNRRWNCSTLDSLPV 60 70 80 90 100 110 110 120 130 140 150 160 pF1KE1 RTGLLKRGFKETAFLYAVSSAALTHTLARACSAGRMERCTCDDSPGLESRQAWQWGVCGD .. .: .:.::.::.:::... ...::::.:..:.: :: . : :..::. :.: XP_011 FGKVVTQGTREAAFVYAISSAGVAFAVTRACSSGELEKCGCDRTVHGVSPQGFQWSGCSD 120 130 140 150 160 170 170 180 190 200 210 220 pF1KE1 NLKYSTKFLSNFLGSK---RGNKDLRARADAHNTHVGIKAVKSGLRTTCKCHGVSGSCAV :. :.. : ..:. . .: .. :: . ::...: ::. . .:. :::::::::: : XP_011 NIAYGVAFSQSFVDVRERSKGASSSRALMNLHNNEAGRKAILTHMRVECKCHGVSGSCEV 180 190 200 210 220 230 230 240 250 260 270 pF1KE1 RTCWKQLSPFRETGQVLKLRYDSAVKVSSATNEALGRLELWAPARQGSLTKGLAPRSG-- .:::. . :::..:..:: ..:.:..: : : :: ...:.::.. XP_011 KTCWRAVPPFRQVGHALKEKFDGATEVE--------------PRRVGS-SRALVPRNAQF 240 250 260 270 280 280 290 300 310 320 pF1KE1 ------DLVYMEDSPSFCRPSKYSP--GTAGRVCSREAS----CSSLCCGRGYDTQSRLV ::::.: ::.::. . : :: ::.:.. .. : ::::::. : . . XP_011 KPHTDEDLVYLEPSPDFCEQDMRSGVLGTRGRTCNKTSKAIDGCELLCCGRGFHTAQVEL 290 300 310 320 330 340 330 340 350 pF1KE1 AFSCHCQVQWCCYVECQQCVQEELVYTCKH : : :. .:::.:.:.:: . ..::. XP_011 AERCSCKFHWCCFVKCRQCQRLVELHTCR 350 360 370 >>NP_005421 (OMIM: 164820,615220,615221) proto-oncogene (370 aa) initn: 804 init1: 480 opt: 833 Z-score: 939.4 bits: 182.4 E(85289): 1.4e-45 Smith-Waterman score: 833; 37.1% identity (63.7% similar) in 372 aa overlap (12-355:17-369) 10 20 30 40 pF1KE1 MRPPPALALAGLCLLALPAAAAS-----YFGL----TGREVLTPFPGLGTAAAPA : : ::::: :. ..:. .. ..:: .: . :. NP_005 MGLWALLPGWVSATLLLALAALPAALAANSSGRWWGIVNVASSTNLLTDSKSLQLVLEPS 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE1 QGGAHLKQCDLLKLSRRQKQLCRREPGLAETLRDAAHLGLLECQFQFRHERWNCS----- : :::.:..: :..::. ... . . .. ::..:::..:::: NP_005 ----------LQLLSRKQRRLIRQNPGILHSVSGGLQSAVRECKWQFRNRRWNCPTAPGP 70 80 90 100 110 110 120 130 140 150 160 pF1KE1 -LEGRTGLLKRGFKETAFLYAVSSAALTHTLARACSAGRMERCTCDDSPGLESRQAWQWG : :. ...:: .::::..:..::..::..::.:: : .: :::: . :.:: NP_005 HLFGK--IVNRGCRETAFIFAITSAGVTHSVARSCSEGSIESCTCDYRRRGPGGPDWHWG 120 130 140 150 160 170 180 190 200 210 220 pF1KE1 VCGDNLKYSTKFLSNFLGSKRGNKDLRARADAHNTHVGIKAVKSGLRTTCKCHGVSGSCA :.::. .. : .:. : . ..::: . ::...: .: : .: :::::.::::. NP_005 GCSDNIDFGRLFGREFVDSGEKGRDLRFLMNLHNNEAGRTTVFSEMRQECKCHGMSGSCT 170 180 190 200 210 220 230 240 250 260 270 pF1KE1 VRTCWKQLSPFRETGQVLKLRYDSAVKV---SSATNEA----LGRLELWAPARQGSLTKG ::::: .: .: .:.::. :.:.: .: . ..:.: : ::: ::.. NP_005 VRTCWMRLPTLRAVGDVLRDRFDGASRVLYGNRGSNRASRAELLRLEPEDPAHK------ 230 240 250 260 270 280 280 290 300 310 320 pF1KE1 LAPRSGDLVYMEDSPSFCRPSKY--SPGTAGRVCSREA----SCSSLCCGRGYDTQSRLV : ::::.: ::.:: : . :::::.:. . .: ::::::. :... : NP_005 -PPSPHDLVYFEKSPNFCTYSGRLGTAGTAGRACNSSSPALDGCELLCCGRGHRTRTQRV 290 300 310 320 330 340 330 340 350 pF1KE1 AFSCHCQVQWCCYVECQQCVQEELVYTCKH . :.: .:::.: :..:.. .... : NP_005 TERCNCTFHWCCHVSCRNCTHTRVLHECL 350 360 370 >>NP_478679 (OMIM: 601967) protein Wnt-7b precursor [Hom (349 aa) initn: 799 init1: 281 opt: 828 Z-score: 934.2 bits: 181.4 E(85289): 2.7e-45 Smith-Waterman score: 828; 35.5% identity (67.6% similar) in 330 aa overlap (39-356:23-349) 10 20 30 40 50 60 pF1KE1 LAGLCLLALPAAAASYFGLTGREVLTPFPGLGTAAAPAQGGAHLKQCDLLKLSRRQKQLC ::. .. . ::.. . :. ::. .: NP_478 MHRNFRKWIFYVFLCFGVLYVKLGALSSVVALGANIICNKIPGLAPRQRAIC 10 20 30 40 50 70 80 90 100 110 120 pF1KE1 RREPGLAETLRDAAHLGLLECQFQFRHERWNCSLEGRTGL----LKRGFKETAFLYAVSS . .: .. ..:..:. :::.::: ::::: :. . :. : .:.:: ::... NP_478 QSRPDAIIVIGEGAQMGINECQYQFRFGRWNCSALGEKTVFGQELRVGSREAAFTYAITA 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE1 AALTHTLARACSAGRMERCTCD-DSPGLESR-QAWQWGVCGDNLKYSTKFLSNFLGSKRG :...:... ::: : . : :: .. : .. ..:.:: :. ...:. : :. ... NP_478 AGVAHAVTAACSQGNLSNCGCDREKQGYYNQAEGWKWGGCSADVRYGIDFSRRFVDAREI 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE1 NKDLRARADAHNTHVGIKAVKSGLRTTCKCHGVSGSCAVRTCWKQLSPFRETGQVLKLRY .:. : . ::...: :.... .. ::::::::::...::: : :::.:..:: .: NP_478 KKNARRLMNLHNNEAGRKVLEDRMQLECKCHGVSGSCTTKTCWTTLPKFREVGHLLKEKY 180 190 200 210 220 230 250 260 270 280 290 300 pF1KE1 DSAVKVSSATNEALGRLELWAPARQGSLTKGLAPRSGDLVYMEDSPSFCRPSKY--SPGT ..::.: . .::. . : .: . : ::::.: ::..:. . : :: NP_478 NAAVQVEVVRA---SRLRQPTFLRIKQLRSYQKPMETDLVYIEKSPNYCEEDAATGSVGT 240 250 260 270 280 310 320 330 340 350 pF1KE1 AGRVCSREA----SCSSLCCGRGYDTQSRLVAFSCHCQVQWCCYVECQQCVQEELVYTCK ::.:.: . .:...::::::.:.. ...:.:. .:::.:.:. : .. :.::: NP_478 QGRLCNRTSPGADGCDTMCCGRGYNTHQYTKVWQCNCKFHWCCFVKCNTCSERTEVFTCK 290 300 310 320 330 340 pF1KE1 H >>NP_004616 (OMIM: 228930,276820,601570) protein Wnt-7a (349 aa) initn: 777 init1: 278 opt: 824 Z-score: 929.7 bits: 180.5 E(85289): 4.8e-45 Smith-Waterman score: 824; 37.0% identity (66.1% similar) in 330 aa overlap (40-356:25-349) 10 20 30 40 50 60 pF1KE1 AGLCLLALPAAAASYFGLTGREVLTPFPGLGTAAAPAQGGAHLKQCDLLK-LSRRQKQLC : ... : :.. . :. . :. ::. .: NP_004 MNRKARRCLGHLFLSLGMVYLRIGGFSSVVALGASII--CNKIPGLAPRQRAIC 10 20 30 40 50 70 80 90 100 110 120 pF1KE1 RREPGLAETLRDAAHLGLLECQFQFRHERWNCSLEG-RTGL---LKRGFKETAFLYAVSS . .: .. .....:: :::::::. ::::: : :: . :: : .:.:: ::. . NP_004 QSRPDAIIVIGEGSQMGLDECQFQFRNGRWNCSALGERTVFGKELKVGSREAAFTYAIIA 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE1 AALTHTLARACSAGRMERCTCD-DSPGLESR-QAWQWGVCGDNLKYSTKFLSNFLGSKRG :...:... ::. : . : :: .. : : ..:.:: :. ...:. : . :. ... NP_004 AGVAHAITAACTQGNLSDCGCDKEKQGQYHRDEGWKWGGCSADIRYGIGFAKVFVDAREI 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE1 NKDLRARADAHNTHVGIKAVKSGLRTTCKCHGVSGSCAVRTCWKQLSPFRETGQVLKLRY ... :. . ::...: : .. ... ::::::::::...::: : ::: : ::: .: NP_004 KQNARTLMNLHNNEAGRKILEENMKLECKCHGVSGSCTTKTCWTTLPQFRELGYVLKDKY 180 190 200 210 220 230 250 260 270 280 290 300 pF1KE1 DSAVKVSSATNEALGRLELWAPARQGSLTKGLAPRSGDLVYMEDSPSFCR--PSKYSPGT . ::.: . : . . : : : . ::::.: ::..:. : : :: NP_004 NEAVHVEPVRASRNKRPTFLKIKKPLSYRK---PMDTDLVYIEKSPNYCEEDPVTGSVGT 240 250 260 270 280 310 320 330 340 350 pF1KE1 AGRVCSREA----SCSSLCCGRGYDTQSRLVAFSCHCQVQWCCYVECQQCVQEELVYTCK ::.:.. : .:. .::::::.:.. ...:.:. .:::::.:. : .. .:::: NP_004 QGRACNKTAPQASGCDLMCCGRGYNTHQYARVWQCNCKFHWCCYVKCNTCSERTEMYTCK 290 300 310 320 330 340 pF1KE1 H 357 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 13:49:15 2016 done: Sun Nov 6 13:49:16 2016 Total Scan time: 7.560 Total Display time: 0.010 Function used was FASTA [36.3.4 Apr, 2011]