FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE6569, 213 aa 1>>>pF1KE6569 213 - 213 aa - 213 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.3757+/-0.000264; mu= 14.8109+/- 0.016 mean_var=84.2881+/-17.163, 0's: 0 Z-trim(122.1): 25 B-trim: 1946 in 1/56 Lambda= 0.139698 statistics sampled from 39551 (39579) to 39551 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.813), E-opt: 0.2 (0.464), width: 16 Scan time: 5.720 The best scores are: opt bits E(85289) NP_079513 (OMIM: 122860,239100,269500,605740) scle ( 213) 1519 314.8 6.9e-86 NP_056279 (OMIM: 609675) sclerostin domain-contain ( 206) 462 101.7 9e-22 XP_016867432 (OMIM: 609675) PREDICTED: sclerostin ( 206) 462 101.7 9e-22 >>NP_079513 (OMIM: 122860,239100,269500,605740) sclerost (213 aa) initn: 1519 init1: 1519 opt: 1519 Z-score: 1663.0 bits: 314.8 E(85289): 6.9e-86 Smith-Waterman score: 1519; 100.0% identity (100.0% similar) in 213 aa overlap (1-213:1-213) 10 20 30 40 50 60 pF1KE6 MQLPLALCLVCLLVHTAFRVVEGQGWQAFKNDATEIIPELGEYPEPPPELENNKTMNRAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 MQLPLALCLVCLLVHTAFRVVEGQGWQAFKNDATEIIPELGEYPEPPPELENNKTMNRAE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 NGGRPPHHPFETKDVSEYSCRELHFTRYVTDGPCRSAKPVTELVCSGQCGPARLLPNAIG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 NGGRPPHHPFETKDVSEYSCRELHFTRYVTDGPCRSAKPVTELVCSGQCGPARLLPNAIG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 RGKWWRPSGPDFRCIPDRYRAQRVQLLCPGGEAPRARKVRLVASCKCKRLTRFHNQSELK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 RGKWWRPSGPDFRCIPDRYRAQRVQLLCPGGEAPRARKVRLVASCKCKRLTRFHNQSELK 130 140 150 160 170 180 190 200 210 pF1KE6 DFGTEAARPQKGRKPRPRARSAKANQAELENAY ::::::::::::::::::::::::::::::::: NP_079 DFGTEAARPQKGRKPRPRARSAKANQAELENAY 190 200 210 >>NP_056279 (OMIM: 609675) sclerostin domain-containing (206 aa) initn: 469 init1: 227 opt: 462 Z-score: 511.9 bits: 101.7 E(85289): 9e-22 Smith-Waterman score: 464; 39.9% identity (65.4% similar) in 208 aa overlap (3-203:11-202) 10 20 30 40 50 pF1KE6 MQLPLALCLVCLLVHTAFRVVEGQGWQAFKNDATEIIPELGEYPEP-PPELE :::: :.:... . :::::::::. .. .: : . NP_056 MLPPAIHFYLLPLA----CILMKSCL---------AFKNDATEIL--YSHVVKPVPAHPS 10 20 30 40 60 70 80 90 100 110 pF1KE6 NNKTMNRAENGGRP-PHHPFETKDVSEYSCRELHFTRYVTDGPCRSAKPVTELVCSGQCG .:.:.:.:.:::: . .. . . .::::. :.:..:: : : .:. ::::.:.: NP_056 SNSTLNQARNGGRHFSNTGLDRNTRVQVGCRELRSTKYISDGQCTSISPLKELVCAGECL 50 60 70 80 90 100 120 130 140 150 160 pF1KE6 PARLLPNAIGRG---KWW-RPSGPDFRCIPDRYRAQRVQLLCPGGEAPRARKVRLVASCK : .::: :: : :.: : :. ..::. :. :.::.:: : : . :. :. .:..:: NP_056 PLPVLPNWIGGGYGTKYWSRRSSQEWRCVNDKTRTQRIQLQCQDG-STRTYKITVVTACK 110 120 130 140 150 160 170 180 190 200 210 pF1KE6 CKRLTRFHNQSELKDFGTEAARPQKGRKPRPRA-RSAKANQAELENAY ::: :: ::.: . . :.: . .. : :: .:.: NP_056 CKRYTRQHNESSHNFESMSPAKPVQHHRERKRASKSSKHSMS 170 180 190 200 >>XP_016867432 (OMIM: 609675) PREDICTED: sclerostin doma (206 aa) initn: 469 init1: 227 opt: 462 Z-score: 511.9 bits: 101.7 E(85289): 9e-22 Smith-Waterman score: 464; 39.9% identity (65.4% similar) in 208 aa overlap (3-203:11-202) 10 20 30 40 50 pF1KE6 MQLPLALCLVCLLVHTAFRVVEGQGWQAFKNDATEIIPELGEYPEP-PPELE :::: :.:... . :::::::::. .. .: : . XP_016 MLPPAIHFYLLPLA----CILMKSCL---------AFKNDATEIL--YSHVVKPVPAHPS 10 20 30 40 60 70 80 90 100 110 pF1KE6 NNKTMNRAENGGRP-PHHPFETKDVSEYSCRELHFTRYVTDGPCRSAKPVTELVCSGQCG .:.:.:.:.:::: . .. . . .::::. :.:..:: : : .:. ::::.:.: XP_016 SNSTLNQARNGGRHFSNTGLDRNTRVQVGCRELRSTKYISDGQCTSISPLKELVCAGECL 50 60 70 80 90 100 120 130 140 150 160 pF1KE6 PARLLPNAIGRG---KWW-RPSGPDFRCIPDRYRAQRVQLLCPGGEAPRARKVRLVASCK : .::: :: : :.: : :. ..::. :. :.::.:: : : . :. :. .:..:: XP_016 PLPVLPNWIGGGYGTKYWSRRSSQEWRCVNDKTRTQRIQLQCQDG-STRTYKITVVTACK 110 120 130 140 150 160 170 180 190 200 210 pF1KE6 CKRLTRFHNQSELKDFGTEAARPQKGRKPRPRA-RSAKANQAELENAY ::: :: ::.: . . :.: . .. : :: .:.: XP_016 CKRYTRQHNESSHNFESMSPAKPVQHHRERKRASKSSKHSMS 170 180 190 200 213 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 10:51:20 2016 done: Tue Nov 8 10:51:21 2016 Total Scan time: 5.720 Total Display time: -0.030 Function used was FASTA [36.3.4 Apr, 2011]