Result of FASTA (omim) for
pFN21AE5785
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE5785, 763 aa
1>>>pF1KE5785 763 - 763 aa - 763 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.3555+/-0.000322; mu= 15.7400+/- 0.020
mean_var=86.7696+/-17.483, 0's: 0 Z-trim(117.4): 13 B-trim: 0 in 0/56
Lambda= 0.137686
statistics sampled from 29326 (29339) to 29326 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.692), E-opt: 0.2 (0.344), width: 16
Scan time: 11.530
The best scores are: opt bits E(85289)
NP_003725 (OMIM: 603735) membrane primary amine ox ( 763) 5275 1057.8 0
NP_001264660 (OMIM: 603735) membrane primary amine ( 634) 4335 871.1 0
XP_011523722 (OMIM: 603735) PREDICTED: membrane pr ( 665) 3661 737.2 5.2e-212
XP_011523721 (OMIM: 603735) PREDICTED: membrane pr ( 794) 3661 737.2 6e-212
NP_033720 (OMIM: 602268) retina-specific copper am ( 756) 3430 691.3 3.8e-198
NP_001149 (OMIM: 602268) retina-specific copper am ( 729) 2672 540.8 7.7e-153
NP_001264661 (OMIM: 603735) membrane primary amine ( 220) 1536 314.9 2.3e-85
NP_001082 (OMIM: 104610) amiloride-sensitive amine ( 751) 1344 277.0 2e-73
XP_016867436 (OMIM: 104610) PREDICTED: amiloride-s ( 751) 1344 277.0 2e-73
XP_016867435 (OMIM: 104610) PREDICTED: amiloride-s ( 770) 907 190.2 2.8e-47
NP_001259001 (OMIM: 104610) amiloride-sensitive am ( 770) 907 190.2 2.8e-47
XP_016867433 (OMIM: 104610) PREDICTED: amiloride-s ( 770) 907 190.2 2.8e-47
XP_016867434 (OMIM: 104610) PREDICTED: amiloride-s ( 770) 907 190.2 2.8e-47
>>NP_003725 (OMIM: 603735) membrane primary amine oxidas (763 aa)
initn: 5275 init1: 5275 opt: 5275 Z-score: 5659.0 bits: 1057.8 E(85289): 0
Smith-Waterman score: 5275; 100.0% identity (100.0% similar) in 763 aa overlap (1-763:1-763)
10 20 30 40 50 60
pF1KE5 MNQKTILVLLILAVITIFALVCVLLVGRGGDGGEPSQLPHCPSVSPSAQPWTHPGQSQLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 MNQKTILVLLILAVITIFALVCVLLVGRGGDGGEPSQLPHCPSVSPSAQPWTHPGQSQLF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 ADLSREELTAVMRFLTQRLGPGLVDAAQARPSDNCVFSVELQLPPKAAALAHLDRGSPPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 ADLSREELTAVMRFLTQRLGPGLVDAAQARPSDNCVFSVELQLPPKAAALAHLDRGSPPP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 AREALAIVFFGRQPQPNVSELVVGPLPHPSYMRDVTVERHGGPLPYHRRPVLFQEYLDID
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 AREALAIVFFGRQPQPNVSELVVGPLPHPSYMRDVTVERHGGPLPYHRRPVLFQEYLDID
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE5 QMIFNRELPQASGLLHHCCFYKHRGRNLVTMTTAPRGLQSGDRATWFGLYYNISGAGFFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 QMIFNRELPQASGLLHHCCFYKHRGRNLVTMTTAPRGLQSGDRATWFGLYYNISGAGFFL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE5 HHVGLELLVNHKALDPARWTIQKVFYQGRYYDSLAQLEAQFEAGLVNVVLIPDNGTGGSW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 HHVGLELLVNHKALDPARWTIQKVFYQGRYYDSLAQLEAQFEAGLVNVVLIPDNGTGGSW
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE5 SLKSPVPPGPAPPLQFYPQGPRFSVQGSRVASSLWTFSFGLGAFSGPRIFDVRFQGERLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 SLKSPVPPGPAPPLQFYPQGPRFSVQGSRVASSLWTFSFGLGAFSGPRIFDVRFQGERLV
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE5 YEISLQEALAIYGGNSPAAMTTRYVDGGFGMGKYTTPLTRGVDCPYLATYVDWHFLLESQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 YEISLQEALAIYGGNSPAAMTTRYVDGGFGMGKYTTPLTRGVDCPYLATYVDWHFLLESQ
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE5 APKTIRDAFCVFEQNQGLPLRRHHSDLYSHYFGGLAETVLVVRSMSTLLNYDYVWDTVFH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 APKTIRDAFCVFEQNQGLPLRRHHSDLYSHYFGGLAETVLVVRSMSTLLNYDYVWDTVFH
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE5 PSGAIEIRFYATGYISSAFLFGATGKYGNQVSEHTLGTVHTHSAHFKVDLDVAGLENWVW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 PSGAIEIRFYATGYISSAFLFGATGKYGNQVSEHTLGTVHTHSAHFKVDLDVAGLENWVW
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE5 AEDMVFVPMAVPWSPEHQLQRLQVTRKLLEMEEQAAFLVGSATPRYLYLASNHSNKWGHP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 AEDMVFVPMAVPWSPEHQLQRLQVTRKLLEMEEQAAFLVGSATPRYLYLASNHSNKWGHP
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE5 RGYRIQMLSFAGEPLPQNSSMARGFSWERYQLAVTQRKEEEPSSSSVFNQNDPWAPTVDF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 RGYRIQMLSFAGEPLPQNSSMARGFSWERYQLAVTQRKEEEPSSSSVFNQNDPWAPTVDF
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE5 SDFINNETIAGKDLVAWVTAGFLHIPHAEDIPNTVTVGNGVGFFLRPYNFFDEDPSFYSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 SDFINNETIAGKDLVAWVTAGFLHIPHAEDIPNTVTVGNGVGFFLRPYNFFDEDPSFYSA
670 680 690 700 710 720
730 740 750 760
pF1KE5 DSIYFRGDQDAGACEVNPLACLPQAAACAPDLPAFSHGGFSHN
:::::::::::::::::::::::::::::::::::::::::::
NP_003 DSIYFRGDQDAGACEVNPLACLPQAAACAPDLPAFSHGGFSHN
730 740 750 760
>>NP_001264660 (OMIM: 603735) membrane primary amine oxi (634 aa)
initn: 4335 init1: 4335 opt: 4335 Z-score: 4651.2 bits: 871.1 E(85289): 0
Smith-Waterman score: 4335; 100.0% identity (100.0% similar) in 629 aa overlap (1-629:1-629)
10 20 30 40 50 60
pF1KE5 MNQKTILVLLILAVITIFALVCVLLVGRGGDGGEPSQLPHCPSVSPSAQPWTHPGQSQLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MNQKTILVLLILAVITIFALVCVLLVGRGGDGGEPSQLPHCPSVSPSAQPWTHPGQSQLF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 ADLSREELTAVMRFLTQRLGPGLVDAAQARPSDNCVFSVELQLPPKAAALAHLDRGSPPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ADLSREELTAVMRFLTQRLGPGLVDAAQARPSDNCVFSVELQLPPKAAALAHLDRGSPPP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 AREALAIVFFGRQPQPNVSELVVGPLPHPSYMRDVTVERHGGPLPYHRRPVLFQEYLDID
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AREALAIVFFGRQPQPNVSELVVGPLPHPSYMRDVTVERHGGPLPYHRRPVLFQEYLDID
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE5 QMIFNRELPQASGLLHHCCFYKHRGRNLVTMTTAPRGLQSGDRATWFGLYYNISGAGFFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QMIFNRELPQASGLLHHCCFYKHRGRNLVTMTTAPRGLQSGDRATWFGLYYNISGAGFFL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE5 HHVGLELLVNHKALDPARWTIQKVFYQGRYYDSLAQLEAQFEAGLVNVVLIPDNGTGGSW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HHVGLELLVNHKALDPARWTIQKVFYQGRYYDSLAQLEAQFEAGLVNVVLIPDNGTGGSW
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE5 SLKSPVPPGPAPPLQFYPQGPRFSVQGSRVASSLWTFSFGLGAFSGPRIFDVRFQGERLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLKSPVPPGPAPPLQFYPQGPRFSVQGSRVASSLWTFSFGLGAFSGPRIFDVRFQGERLV
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE5 YEISLQEALAIYGGNSPAAMTTRYVDGGFGMGKYTTPLTRGVDCPYLATYVDWHFLLESQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YEISLQEALAIYGGNSPAAMTTRYVDGGFGMGKYTTPLTRGVDCPYLATYVDWHFLLESQ
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE5 APKTIRDAFCVFEQNQGLPLRRHHSDLYSHYFGGLAETVLVVRSMSTLLNYDYVWDTVFH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 APKTIRDAFCVFEQNQGLPLRRHHSDLYSHYFGGLAETVLVVRSMSTLLNYDYVWDTVFH
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE5 PSGAIEIRFYATGYISSAFLFGATGKYGNQVSEHTLGTVHTHSAHFKVDLDVAGLENWVW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PSGAIEIRFYATGYISSAFLFGATGKYGNQVSEHTLGTVHTHSAHFKVDLDVAGLENWVW
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE5 AEDMVFVPMAVPWSPEHQLQRLQVTRKLLEMEEQAAFLVGSATPRYLYLASNHSNKWGHP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AEDMVFVPMAVPWSPEHQLQRLQVTRKLLEMEEQAAFLVGSATPRYLYLASNHSNKWGHP
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE5 RGYRIQMLSFAGEPLPQNSSMARGFSWERYQLAVTQRKEEEPSSSSVFNQNDPWAPTVDF
:::::::::::::::::::::::::::::
NP_001 RGYRIQMLSFAGEPLPQNSSMARGFSWERIWWPG
610 620 630
>>XP_011523722 (OMIM: 603735) PREDICTED: membrane primar (665 aa)
initn: 3660 init1: 3660 opt: 3661 Z-score: 3927.3 bits: 737.2 E(85289): 5.2e-212
Smith-Waterman score: 4263; 95.3% identity (95.3% similar) in 660 aa overlap (1-629:1-660)
10 20 30 40 50 60
pF1KE5 MNQKTILVLLILAVITIFALVCVLLVGRGGDGGEPSQLPHCPSVSPSAQPWTHPGQSQLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MNQKTILVLLILAVITIFALVCVLLVGRGGDGGEPSQLPHCPSVSPSAQPWTHPGQSQLF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 ADLSREELTAVMRFLTQRLGPGLVDAAQARPSDNCVFSVELQLPPKAAALAHLDRGSPPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ADLSREELTAVMRFLTQRLGPGLVDAAQARPSDNCVFSVELQLPPKAAALAHLDRGSPPP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 AREALAIVFFGRQPQPNVSELVVGPLPHPSYMRDVTVERHGGPLPYHRRPVLFQEYLDID
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AREALAIVFFGRQPQPNVSELVVGPLPHPSYMRDVTVERHGGPLPYHRRPVLFQEYLDID
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE5 QMIFNRELPQASGLLHHCCFYKHRGRNLVTMTTAPRGLQSGDRATWFGLYYNISGAGFFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QMIFNRELPQASGLLHHCCFYKHRGRNLVTMTTAPRGLQSGDRATWFGLYYNISGAGFFL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE5 HHVGLELLVNHKALDPARWTIQKVFYQGRYYDSLAQLEAQFEAGLVNVVLIPDNGTGGSW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HHVGLELLVNHKALDPARWTIQKVFYQGRYYDSLAQLEAQFEAGLVNVVLIPDNGTGGSW
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE5 SLKSPVPPGPAPPLQFYPQGPRFSVQGSRVASSLWTFSFGLGAFSGPRIFDVRFQGERLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SLKSPVPPGPAPPLQFYPQGPRFSVQGSRVASSLWTFSFGLGAFSGPRIFDVRFQGERLV
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE5 YEISLQEALAIYGGNSPAAMTTRYVDGGFGMGKYTTPLTRGVDCPYLATYVDWHFLLESQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YEISLQEALAIYGGNSPAAMTTRYVDGGFGMGKYTTPLTRGVDCPYLATYVDWHFLLESQ
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE5 APKTIRDAFCVFEQNQGLPLRRHHSDLYSHYFGGLAETVLVVRSMSTLLNYDYVWDTVFH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 APKTIRDAFCVFEQNQGLPLRRHHSDLYSHYFGGLAETVLVVRSMSTLLNYDYVWDTVFH
430 440 450 460 470 480
490 500 510 520 530
pF1KE5 PSGAIEIRFYATGYISSAFLFGATGKYGNQVSEHTLGTVHTHSAHFKVDLDVA-------
:::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PSGAIEIRFYATGYISSAFLFGATGKYGNQVSEHTLGTVHTHSAHFKVDLDVAAFCLSAQ
490 500 510 520 530 540
540 550 560
pF1KE5 ------------------------GLENWVWAEDMVFVPMAVPWSPEHQLQRLQVTRKLL
::::::::::::::::::::::::::::::::::::
XP_011 FCVWPVVVVFWRISLHSTTSLACAGLENWVWAEDMVFVPMAVPWSPEHQLQRLQVTRKLL
550 560 570 580 590 600
570 580 590 600 610 620
pF1KE5 EMEEQAAFLVGSATPRYLYLASNHSNKWGHPRGYRIQMLSFAGEPLPQNSSMARGFSWER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EMEEQAAFLVGSATPRYLYLASNHSNKWGHPRGYRIQMLSFAGEPLPQNSSMARGFSWER
610 620 630 640 650 660
630 640 650 660 670 680
pF1KE5 YQLAVTQRKEEEPSSSSVFNQNDPWAPTVDFSDFINNETIAGKDLVAWVTAGFLHIPHAE
XP_011 IWWPG
>>XP_011523721 (OMIM: 603735) PREDICTED: membrane primar (794 aa)
initn: 3703 init1: 3660 opt: 3661 Z-score: 3926.1 bits: 737.2 E(85289): 6e-212
Smith-Waterman score: 5203; 96.1% identity (96.1% similar) in 794 aa overlap (1-763:1-794)
10 20 30 40 50 60
pF1KE5 MNQKTILVLLILAVITIFALVCVLLVGRGGDGGEPSQLPHCPSVSPSAQPWTHPGQSQLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MNQKTILVLLILAVITIFALVCVLLVGRGGDGGEPSQLPHCPSVSPSAQPWTHPGQSQLF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 ADLSREELTAVMRFLTQRLGPGLVDAAQARPSDNCVFSVELQLPPKAAALAHLDRGSPPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ADLSREELTAVMRFLTQRLGPGLVDAAQARPSDNCVFSVELQLPPKAAALAHLDRGSPPP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 AREALAIVFFGRQPQPNVSELVVGPLPHPSYMRDVTVERHGGPLPYHRRPVLFQEYLDID
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AREALAIVFFGRQPQPNVSELVVGPLPHPSYMRDVTVERHGGPLPYHRRPVLFQEYLDID
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE5 QMIFNRELPQASGLLHHCCFYKHRGRNLVTMTTAPRGLQSGDRATWFGLYYNISGAGFFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QMIFNRELPQASGLLHHCCFYKHRGRNLVTMTTAPRGLQSGDRATWFGLYYNISGAGFFL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE5 HHVGLELLVNHKALDPARWTIQKVFYQGRYYDSLAQLEAQFEAGLVNVVLIPDNGTGGSW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HHVGLELLVNHKALDPARWTIQKVFYQGRYYDSLAQLEAQFEAGLVNVVLIPDNGTGGSW
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE5 SLKSPVPPGPAPPLQFYPQGPRFSVQGSRVASSLWTFSFGLGAFSGPRIFDVRFQGERLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SLKSPVPPGPAPPLQFYPQGPRFSVQGSRVASSLWTFSFGLGAFSGPRIFDVRFQGERLV
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE5 YEISLQEALAIYGGNSPAAMTTRYVDGGFGMGKYTTPLTRGVDCPYLATYVDWHFLLESQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YEISLQEALAIYGGNSPAAMTTRYVDGGFGMGKYTTPLTRGVDCPYLATYVDWHFLLESQ
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE5 APKTIRDAFCVFEQNQGLPLRRHHSDLYSHYFGGLAETVLVVRSMSTLLNYDYVWDTVFH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 APKTIRDAFCVFEQNQGLPLRRHHSDLYSHYFGGLAETVLVVRSMSTLLNYDYVWDTVFH
430 440 450 460 470 480
490 500 510 520 530
pF1KE5 PSGAIEIRFYATGYISSAFLFGATGKYGNQVSEHTLGTVHTHSAHFKVDLDVA-------
:::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PSGAIEIRFYATGYISSAFLFGATGKYGNQVSEHTLGTVHTHSAHFKVDLDVAAFCLSAQ
490 500 510 520 530 540
540 550 560
pF1KE5 ------------------------GLENWVWAEDMVFVPMAVPWSPEHQLQRLQVTRKLL
::::::::::::::::::::::::::::::::::::
XP_011 FCVWPVVVVFWRISLHSTTSLACAGLENWVWAEDMVFVPMAVPWSPEHQLQRLQVTRKLL
550 560 570 580 590 600
570 580 590 600 610 620
pF1KE5 EMEEQAAFLVGSATPRYLYLASNHSNKWGHPRGYRIQMLSFAGEPLPQNSSMARGFSWER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EMEEQAAFLVGSATPRYLYLASNHSNKWGHPRGYRIQMLSFAGEPLPQNSSMARGFSWER
610 620 630 640 650 660
630 640 650 660 670 680
pF1KE5 YQLAVTQRKEEEPSSSSVFNQNDPWAPTVDFSDFINNETIAGKDLVAWVTAGFLHIPHAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YQLAVTQRKEEEPSSSSVFNQNDPWAPTVDFSDFINNETIAGKDLVAWVTAGFLHIPHAE
670 680 690 700 710 720
690 700 710 720 730 740
pF1KE5 DIPNTVTVGNGVGFFLRPYNFFDEDPSFYSADSIYFRGDQDAGACEVNPLACLPQAAACA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DIPNTVTVGNGVGFFLRPYNFFDEDPSFYSADSIYFRGDQDAGACEVNPLACLPQAAACA
730 740 750 760 770 780
750 760
pF1KE5 PDLPAFSHGGFSHN
::::::::::::::
XP_011 PDLPAFSHGGFSHN
790
>>NP_033720 (OMIM: 602268) retina-specific copper amine (756 aa)
initn: 1817 init1: 1817 opt: 3430 Z-score: 3678.4 bits: 691.3 E(85289): 3.8e-198
Smith-Waterman score: 3430; 65.4% identity (84.9% similar) in 762 aa overlap (1-760:1-756)
10 20 30 40 50 60
pF1KE5 MNQKTILVLLILAVITIFALVCVLLVGRGGDGGEPSQLPHCPSVSPSAQPWTHPGQSQLF
:. : .:..: :..::::::. :::.. ::. :: ::::::: :::: ::::::::
NP_033 MHLKIVLAFLALSLITIFALAYVLLTSPGGS----SQPPHCPSVSHRAQPWPHPGQSQLF
10 20 30 40 50
70 80 90 100 110 120
pF1KE5 ADLSREELTAVMRFLTQRLGPGLVDAAQARPSDNCVFSVELQLPPKAAALAHLDRGSPPP
:::::::::::::::::::::::::::::.:::::.::::::::::::::::::::::::
NP_033 ADLSREELTAVMRFLTQRLGPGLVDAAQAQPSDNCIFSVELQLPPKAAALAHLDRGSPPP
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE5 AREALAIVFFGRQPQPNVSELVVGPLPHPSYMRDVTVERHGGPLPYHRRPVLFQEYLDID
::::::::.:: :::::::::::::::::::::::::::::::::::::::: :. ..
NP_033 AREALAIVLFGGQPQPNVSELVVGPLPHPSYMRDVTVERHGGPLPYHRRPVLRAEFTQMW
120 130 140 150 160 170
190 200 210 220 230 240
pF1KE5 QMIFNRELPQASGLLHHCCFYKHRGRNLVTMTTAPRGLQSGDRATWFGLYYNISGAGFFL
. . . :::.: .: ... : .:... ..::::.:::::::..::.::::.:.::
NP_033 RHLKEVELPKAPIFLSST--FNYNGSTLAAVHATPRGLRSGDRATWMALYHNISGVGLFL
180 190 200 210 220 230
250 260 270 280 290 300
pF1KE5 HHVGLELLVNHKALDPARWTIQKVFYQGRYYDSLAQLEAQFEAGLVNVVLIPDNGTGGSW
: ::::::..:.:::::.::.:.::: :.:: .:.::: .:..: ..:: .: .:.
NP_033 HPVGLELLLDHRALDPAHWTVQQVFYLGHYYADLGQLEREFKSGRLEVVRVPLPPPNGAS
240 250 260 270 280 290
310 320 330 340 350 360
pF1KE5 SLKSPVPPGPAPPLQFYPQGPRFSVQGSRVASSLWTFSFGLGAFSGPRIFDVRFQGERLV
::.: ::: ::::: ::: ..::::. :.::::.:.:: :.::: :::::::::::..
NP_033 SLRSRNSPGPLPPLQFSPQGSQYSVQGNLVVSSLWSFTFGHGVFSGLRIFDVRFQGERIA
300 310 320 330 340 350
370 380 390 400 410 420
pF1KE5 YEISLQEALAIYGGNSPAAMTTRYVDGGFGMGKYTTPLTRGVDCPYLATYVDWHFLLESQ
::.:.:: ..:::..:: .: :::.:..::.:. . :.::::::: ::.:: :.:. .
NP_033 YEVSVQECVSIYGADSPKTMLTRYLDSSFGLGRNSRGLVRGVDCPYQATMVDIHILVGKG
360 370 380 390 400 410
430 440 450 460 470 480
pF1KE5 APKTIRDAFCVFEQNQGLPLRRHHSDLYSHYFGGLAETVLVVRSMSTLLNYDYVWDTVFH
: . . : ::::. :::::::::. : .:..:::: ..:::::.:.. ::::.:: :..
NP_033 AVQLLPGAVCVFEEAQGLPLRRHHNYLQNHFYGGLASSALVVRSVSSVGNYDYIWDFVLY
420 430 440 450 460 470
490 500 510 520 530
pF1KE5 PSGAIEIRFYATGYISSAFLFGATGK--YGNQVSEHTLGTVHTHSAHFKVDLDVAGLENW
:.::.: : .:::::..::: :. .::.:.:..:::::::. :::.:::::::.::
NP_033 PNGALEGRVHATGYINTAFLKGGEEGLLFGNRVGERVLGTVHTHAFHFKLDLDVAGLKNW
480 490 500 510 520 530
540 550 560 570 580 590
pF1KE5 VWAEDMVFVPMAVPWSPEHQLQRLQVTRKLLEMEEQAAFLVGSATPRYLYLASNHSNKWG
: :::.:: :.:.::.::: ::: :.::..: :. .:: .:: :::::::::..: ::
NP_033 VVAEDVVFKPVAAPWNPEHWLQRPQLTRQVLGKEDLTAFSLGSPLPRYLYLASNQTNAWG
540 550 560 570 580 590
600 610 620 630 640 650
pF1KE5 HPRGYRIQMLSFAGEPLPQNSSMARGFSWERYQLAVTQRKEEEPSSSSVFNQNDPWAPTV
: ::::::. : : .: .:.: :..:: ::::.:::::::: .:::...::: :.:::
NP_033 HQRGYRIQIHSPLGIHIPLESDMERALSWGRYQLVVTQRKEEESQSSSIYHQNDIWTPTV
600 610 620 630 640 650
660 670 680 690 700 710
pF1KE5 DFSDFINNETIAGKDLVAWVTAGFLHIPHAEDIPNTVTVGNGVGFFLRPYNFFDEDPSFY
:.:::::::. :.::::::::.:::::::::::::::.:: :::.::::::::::::..
NP_033 TFADFINNETLLGEDLVAWVTASFLHIPHAEDIPNTVTLGNRVGFLLRPYNFFDEDPSIF
660 670 680 690 700 710
720 730 740 750 760
pF1KE5 SADSIYFRGDQDAGACEVNPLACLPQAAACAPDLPAFSHGGFSHN
: :.::. :::: : .::.::::. :::.:::: ::. ::
NP_033 SPGSVYFEKGQDAGLCSINPVACLPDLAACVPDLPPFSYHGF
720 730 740 750
>>NP_001149 (OMIM: 602268) retina-specific copper amine (729 aa)
initn: 2362 init1: 1246 opt: 2672 Z-score: 2864.9 bits: 540.8 E(85289): 7.7e-153
Smith-Waterman score: 3286; 63.6% identity (82.4% similar) in 762 aa overlap (1-760:1-729)
10 20 30 40 50 60
pF1KE5 MNQKTILVLLILAVITIFALVCVLLVGRGGDGGEPSQLPHCPSVSPSAQPWTHPGQSQLF
:. : .:..: :..::::::. :::.. ::. :: ::::::: :::: ::::::::
NP_001 MHLKIVLAFLALSLITIFALAYVLLTSPGGS----SQPPHCPSVSHRAQPWPHPGQSQLF
10 20 30 40 50
70 80 90 100 110 120
pF1KE5 ADLSREELTAVMRFLTQRLGPGLVDAAQARPSDNCVFSVELQLPPKAAALAHLDRGSPPP
:::::::::::::::::::::::::::::.:::::.::::::::::::::::::::::::
NP_001 ADLSREELTAVMRFLTQRLGPGLVDAAQAQPSDNCIFSVELQLPPKAAALAHLDRGSPPP
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE5 AREALAIVFFGRQPQPNVSELVVGPLPHPSYMRDVTVERHGGPLPYHRRPVLFQEYLDID
::::::::.:: :::::::::::::::::::::::::::::::::::::::: :. ..
NP_001 AREALAIVLFGGQPQPNVSELVVGPLPHPSYMRDVTVERHGGPLPYHRRPVLRAEFTQMW
120 130 140 150 160 170
190 200 210 220 230 240
pF1KE5 QMIFNRELPQASGLLHHCCFYKHRGRNLVTMTTAPRGLQSGDRATWFGLYYNISGAGFFL
. . . :::.: .: ... : .:... ..::::.:::::::..::.::::.:.::
NP_001 RHLKEVELPKAPIFLSST--FNYNGSTLAAVHATPRGLRSGDRATWMALYHNISGVGLFL
180 190 200 210 220 230
250 260 270 280 290 300
pF1KE5 HHVGLELLVNHKALDPARWTIQKVFYQGRYYDSLAQLEAQFEAGLVNVVLIPDNGTGGSW
: ::::::..:.:::::.::.:.::: :.:: .:.::: .:..: ..:: .: .:.
NP_001 HPVGLELLLDHRALDPAHWTVQQVFYLGHYYADLGQLEREFKSGRLEVVRVPLPPPNGAS
240 250 260 270 280 290
310 320 330 340 350 360
pF1KE5 SLKSPVPPGPAPPLQFYPQGPRFSVQGSRVASSLWTFSFGLGAFSGPRIFDVRFQGERLV
::.: ::: ::::: ::: ..::::. :.::::.:.:: :.::: :::::::::::..
NP_001 SLRSRNSPGPLPPLQFSPQGSQYSVQGNLVVSSLWSFTFGHGVFSGLRIFDVRFQGERIA
300 310 320 330 340 350
370 380 390 400 410 420
pF1KE5 YEISLQEALAIYGGNSPAAMTTRYVDGGFGMGKYTTPLTRGVDCPYLATYVDWHFLLESQ
::.:.:: ..:::..:: .: :::.:..::.:. . :.::::::: ::.:: :.:. .
NP_001 YEVSVQECVSIYGADSPKTMLTRYLDSSFGLGRNSRGLVRGVDCPYQATMVDIHILVGKG
360 370 380 390 400 410
430 440 450 460 470 480
pF1KE5 APKTIRDAFCVFEQNQGLPLRRHHSDLYSHYFGGLAETVLVVRSMSTLLNYDYVWDTVFH
: . . : ::::. :::::::::. : .:..:::: ..:::::.:.. ::::.:: :..
NP_001 AVQLLPGAVCVFEEAQGLPLRRHHNYLQNHFYGGLASSALVVRSVSSVGNYDYIWDFVLY
420 430 440 450 460 470
490 500 510 520 530
pF1KE5 PSGAIEIRFYATGYISSAFLFGATGK--YGNQVSEHTLGTVHTHSAHFKVDLDVAGLENW
:.::.: : .:::::..::: :. .::.:.:..:::::::. :::.:::::::.::
NP_001 PNGALEGRVHATGYINTAFLKGGEEGLLFGNRVGERVLGTVHTHAFHFKLDLDVAGLKNW
480 490 500 510 520 530
540 550 560 570 580 590
pF1KE5 VWAEDMVFVPMAVPWSPEHQLQRLQVTRKLLEMEEQAAFLVGSATPRYLYLASNHSNKWG
: :::.:: :.:.::.::: ::: :.::..: :. .:: .:: :::::::::..: ::
NP_001 VVAEDVVFKPVAAPWNPEHWLQRPQLTRQVLGKEDLTAFSLGSPLPRYLYLASNQTNAWG
540 550 560 570 580 590
600 610 620 630 640 650
pF1KE5 HPRGYRIQMLSFAGEPLPQNSSMARGFSWERYQLAVTQRKEEEPSSSSVFNQNDPWAPTV
: ::: ::.:::::::: .:::...::: :.:::
NP_001 HQRGY---------------------------QLVVTQRKEEESQSSSIYHQNDIWTPTV
600 610 620
660 670 680 690 700 710
pF1KE5 DFSDFINNETIAGKDLVAWVTAGFLHIPHAEDIPNTVTVGNGVGFFLRPYNFFDEDPSFY
:.:::::::. :.::::::::.:::::::::::::::.:: :::.::::::::::::..
NP_001 TFADFINNETLLGEDLVAWVTASFLHIPHAEDIPNTVTLGNRVGFLLRPYNFFDEDPSIF
630 640 650 660 670 680
720 730 740 750 760
pF1KE5 SADSIYFRGDQDAGACEVNPLACLPQAAACAPDLPAFSHGGFSHN
: :.::. :::: : .::.::::. :::.:::: ::. ::
NP_001 SPGSVYFEKGQDAGLCSINPVACLPDLAACVPDLPPFSYHGF
690 700 710 720
>>NP_001264661 (OMIM: 603735) membrane primary amine oxi (220 aa)
initn: 1536 init1: 1536 opt: 1536 Z-score: 1653.6 bits: 314.9 E(85289): 2.3e-85
Smith-Waterman score: 1536; 100.0% identity (100.0% similar) in 220 aa overlap (544-763:1-220)
520 530 540 550 560 570
pF1KE5 HTLGTVHTHSAHFKVDLDVAGLENWVWAEDMVFVPMAVPWSPEHQLQRLQVTRKLLEMEE
::::::::::::::::::::::::::::::
NP_001 MVFVPMAVPWSPEHQLQRLQVTRKLLEMEE
10 20 30
580 590 600 610 620 630
pF1KE5 QAAFLVGSATPRYLYLASNHSNKWGHPRGYRIQMLSFAGEPLPQNSSMARGFSWERYQLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QAAFLVGSATPRYLYLASNHSNKWGHPRGYRIQMLSFAGEPLPQNSSMARGFSWERYQLA
40 50 60 70 80 90
640 650 660 670 680 690
pF1KE5 VTQRKEEEPSSSSVFNQNDPWAPTVDFSDFINNETIAGKDLVAWVTAGFLHIPHAEDIPN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VTQRKEEEPSSSSVFNQNDPWAPTVDFSDFINNETIAGKDLVAWVTAGFLHIPHAEDIPN
100 110 120 130 140 150
700 710 720 730 740 750
pF1KE5 TVTVGNGVGFFLRPYNFFDEDPSFYSADSIYFRGDQDAGACEVNPLACLPQAAACAPDLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TVTVGNGVGFFLRPYNFFDEDPSFYSADSIYFRGDQDAGACEVNPLACLPQAAACAPDLP
160 170 180 190 200 210
760
pF1KE5 AFSHGGFSHN
::::::::::
NP_001 AFSHGGFSHN
220
>>NP_001082 (OMIM: 104610) amiloride-sensitive amine oxi (751 aa)
initn: 1438 init1: 631 opt: 1344 Z-score: 1439.1 bits: 277.0 E(85289): 2e-73
Smith-Waterman score: 1850; 40.1% identity (66.0% similar) in 736 aa overlap (46-759:21-746)
20 30 40 50 60 70
pF1KE5 TIFALVCVLLVGRGGDGGEPSQLPHCPSVSPSAQPWTHPGQSQLFADLSREELTAVMRFL
:: : : : .. .:.::: .:: :: ::
NP_001 MPALGWAVAAILMLQTAMAEPS--PGTLPRKAGVFSDLSNQELKAVHSFL
10 20 30 40
80 90 100 110 120 130
pF1KE5 TQRLGPGLVDAAQARPSDNCVFSVELQLPPKAAALAHLDRGSPPPAREALAIVFFGRQPQ
.. : .. . . : :: .:. :: : .: ::.: :.::: :..::: : .
NP_001 WSKKELRLQPSSTTTMAKNTVFLIEMLLPKKYHVLRFLDKGERHPVREARAVIFFGDQEH
50 60 70 80 90 100
140 150 160 170 180 190
pF1KE5 PNVSELVVGPLPHPSYMRDVTVERHGGPLPYHRRPVLFQEYLDIDQMIFNRELPQASGLL
:::.:..::::: : ::: .. : : . ::. :: . . . . : . .:
NP_001 PNVTEFAVGPLPGPCYMRALS-PRPGYQSSWASRPISTAEYALLYHTLQEATKPLHQFFL
110 120 130 140 150 160
200 210 220 230 240 250
pF1KE5 HHC--CFYKHRGRNLVTMTTAPRGLQSGDRATWFGLYYNISGAGFFLHHVGLELLVNHKA
. : . : :. .::::. ::.: .:. . . :.::: .::::::.: .
NP_001 NTTGFSFQDCHDRCLAFTDVAPRGVASGQRRSWLIIQRYVE--GYFLHPTGLELLVDHGS
170 180 190 200 210 220
260 270 280 290 300
pF1KE5 LDPARWTIQKVFYQGRYYDSLAQLEAQFEAGLVNVVLIPDNGTGGSWSLKSPVPP-----
: ..:....:.:.:..: : .: .. : :.::.. : ::. .. ::
NP_001 TDAGHWAVEQVWYNGKFYGSPEELARKYADGEVDVVVLEDPLPGGKGHDSTEEPPLFSSH
230 240 250 260 270 280
310 320 330 340 350
pF1KE5 ---G--PAP-----PLQFYPQGPRFSVQGSRVASSLWTFSFGLGAFSGPRIFDVRFQGER
: :.: : :.:::: ..:. : . :.:.: : . :: ....:.: :::
NP_001 KPRGDFPSPIHVSGPRLVQPHGPRFRLEGNAVLYGGWSFAFRLRSSSGLQVLNVHFGGER
290 300 310 320 330 340
360 370 380 390 400 410
pF1KE5 LVYEISLQEALAIYGGNSPAAMTTRYVDGGFGMGKYTTPLTRGVDCPYLATYVDWHFLLE
..::.:.:::.:.:::..::.: :.:.: :.:.:. : :. :.::: ::..: .
NP_001 IAYEVSVQEAVALYGGHTPAGMQTKYLDVGWGLGSVTHELAPGIDCPETATFLDTFHYYD
350 360 370 380 390 400
420 430 440 450 460 470
pF1KE5 SQAPKTIRDAFCVFEQNQGLPLRRHHSDLYS---HYFGGLAETVLVVRSMSTLLNYDYVW
.. : :.:.::. :.::::: .. .. ....:: :::.:. ::. ::::.:
NP_001 ADDPVHYPRALCLFEMPTGVPLRRHFNSNFKGGFNFYAGLKGQVLVLRTTSTVYNYDYIW
410 420 430 440 450 460
480 490 500 510 520 530
pF1KE5 DTVFHPSGAIEIRFYATGYISSAFLFGATGKYGNQVSEHTLGTVHTHSAHFKVDLDVAGL
: .:.:.:..: ...::::. ..: ..:... : .:..::: .:..:::::::
NP_001 DFIFYPNGVMEAKMHATGYVHATFYTPEGLRHGTRLHTHLIGNIHTHLVHYRVDLDVAGT
470 480 490 500 510 520
540 550 560 570 580 590
pF1KE5 ENWVWAEDMVFVPMAVPWSPEHQLQRLQVTRKLLEMEEQAAFLVGSATPRYLYLASNHSN
.: . .: . .. ::::.:.. . . . :.:::: :.:: ..: . :
NP_001 KNSFQTLQMKLENITNPWSPRHRVVQPTLEQTQYSWERQAAFRFKRKLPKYLLFTSPQEN
530 540 550 560 570 580
600 610 620 630 640 650
pF1KE5 KWGHPRGYRIQMLSFAGEPLPQNSSMARGFSWERYQLAVTQRKEEEPSSSSVFNQNDPWA
::: : ::.:. :.: . :: . . ....: :: ::::. .: : :::...:::::
NP_001 PWGHKRTYRLQIHSMADQVLPPGWQEEQAITWARYPLAVTKYRESELCSSSIYHQNDPWH
590 600 610 620 630 640
660 670 680 690 700 710
pF1KE5 PTVDFSDFI-NNETIAGKDLVAWVTAGFLHIPHAEDIPNTVTVGNGVGFFLRPYNFFDED
: : : .:. :::.: ..:::::::.:::::::.::::::.: ::.:::.:::.::: ::
NP_001 PPVVFEQFLHNNENIENEDLVAWVTVGFLHIPHSEDIPNTATPGNSVGFLLRPFNFFPED
650 660 670 680 690 700
720 730 740 750 760
pF1KE5 PSFYSADSIYFRGDQDAGACEVNPLACLPQAAACA-PDLPAFSHGGFSHN
::. : :.. .: : :. .:. :. : : ::..:
NP_001 PSLASRDTVIVW-PRDNGPNYVQRW--IPEDRDCSMP--PPFSYNGTYRPV
710 720 730 740 750
>>XP_016867436 (OMIM: 104610) PREDICTED: amiloride-sensi (751 aa)
initn: 1438 init1: 631 opt: 1344 Z-score: 1439.1 bits: 277.0 E(85289): 2e-73
Smith-Waterman score: 1850; 40.1% identity (66.0% similar) in 736 aa overlap (46-759:21-746)
20 30 40 50 60 70
pF1KE5 TIFALVCVLLVGRGGDGGEPSQLPHCPSVSPSAQPWTHPGQSQLFADLSREELTAVMRFL
:: : : : .. .:.::: .:: :: ::
XP_016 MPALGWAVAAILMLQTAMAEPS--PGTLPRKAGVFSDLSNQELKAVHSFL
10 20 30 40
80 90 100 110 120 130
pF1KE5 TQRLGPGLVDAAQARPSDNCVFSVELQLPPKAAALAHLDRGSPPPAREALAIVFFGRQPQ
.. : .. . . : :: .:. :: : .: ::.: :.::: :..::: : .
XP_016 WSKKELRLQPSSTTTMAKNTVFLIEMLLPKKYHVLRFLDKGERHPVREARAVIFFGDQEH
50 60 70 80 90 100
140 150 160 170 180 190
pF1KE5 PNVSELVVGPLPHPSYMRDVTVERHGGPLPYHRRPVLFQEYLDIDQMIFNRELPQASGLL
:::.:..::::: : ::: .. : : . ::. :: . . . . : . .:
XP_016 PNVTEFAVGPLPGPCYMRALS-PRPGYQSSWASRPISTAEYALLYHTLQEATKPLHQFFL
110 120 130 140 150 160
200 210 220 230 240 250
pF1KE5 HHC--CFYKHRGRNLVTMTTAPRGLQSGDRATWFGLYYNISGAGFFLHHVGLELLVNHKA
. : . : :. .::::. ::.: .:. . . :.::: .::::::.: .
XP_016 NTTGFSFQDCHDRCLAFTDVAPRGVASGQRRSWLIIQRYVE--GYFLHPTGLELLVDHGS
170 180 190 200 210 220
260 270 280 290 300
pF1KE5 LDPARWTIQKVFYQGRYYDSLAQLEAQFEAGLVNVVLIPDNGTGGSWSLKSPVPP-----
: ..:....:.:.:..: : .: .. : :.::.. : ::. .. ::
XP_016 TDAGHWAVEQVWYNGKFYGSPEELARKYADGEVDVVVLEDPLPGGKGHDSTEEPPLFSSH
230 240 250 260 270 280
310 320 330 340 350
pF1KE5 ---G--PAP-----PLQFYPQGPRFSVQGSRVASSLWTFSFGLGAFSGPRIFDVRFQGER
: :.: : :.:::: ..:. : . :.:.: : . :: ....:.: :::
XP_016 KPRGDFPSPIHVSGPRLVQPHGPRFRLEGNAVLYGGWSFAFRLRSSSGLQVLNVHFGGER
290 300 310 320 330 340
360 370 380 390 400 410
pF1KE5 LVYEISLQEALAIYGGNSPAAMTTRYVDGGFGMGKYTTPLTRGVDCPYLATYVDWHFLLE
..::.:.:::.:.:::..::.: :.:.: :.:.:. : :. :.::: ::..: .
XP_016 IAYEVSVQEAVALYGGHTPAGMQTKYLDVGWGLGSVTHELAPGIDCPETATFLDTFHYYD
350 360 370 380 390 400
420 430 440 450 460 470
pF1KE5 SQAPKTIRDAFCVFEQNQGLPLRRHHSDLYS---HYFGGLAETVLVVRSMSTLLNYDYVW
.. : :.:.::. :.::::: .. .. ....:: :::.:. ::. ::::.:
XP_016 ADDPVHYPRALCLFEMPTGVPLRRHFNSNFKGGFNFYAGLKGQVLVLRTTSTVYNYDYIW
410 420 430 440 450 460
480 490 500 510 520 530
pF1KE5 DTVFHPSGAIEIRFYATGYISSAFLFGATGKYGNQVSEHTLGTVHTHSAHFKVDLDVAGL
: .:.:.:..: ...::::. ..: ..:... : .:..::: .:..:::::::
XP_016 DFIFYPNGVMEAKMHATGYVHATFYTPEGLRHGTRLHTHLIGNIHTHLVHYRVDLDVAGT
470 480 490 500 510 520
540 550 560 570 580 590
pF1KE5 ENWVWAEDMVFVPMAVPWSPEHQLQRLQVTRKLLEMEEQAAFLVGSATPRYLYLASNHSN
.: . .: . .. ::::.:.. . . . :.:::: :.:: ..: . :
XP_016 KNSFQTLQMKLENITNPWSPRHRVVQPTLEQTQYSWERQAAFRFKRKLPKYLLFTSPQEN
530 540 550 560 570 580
600 610 620 630 640 650
pF1KE5 KWGHPRGYRIQMLSFAGEPLPQNSSMARGFSWERYQLAVTQRKEEEPSSSSVFNQNDPWA
::: : ::.:. :.: . :: . . ....: :: ::::. .: : :::...:::::
XP_016 PWGHKRTYRLQIHSMADQVLPPGWQEEQAITWARYPLAVTKYRESELCSSSIYHQNDPWH
590 600 610 620 630 640
660 670 680 690 700 710
pF1KE5 PTVDFSDFI-NNETIAGKDLVAWVTAGFLHIPHAEDIPNTVTVGNGVGFFLRPYNFFDED
: : : .:. :::.: ..:::::::.:::::::.::::::.: ::.:::.:::.::: ::
XP_016 PPVVFEQFLHNNENIENEDLVAWVTVGFLHIPHSEDIPNTATPGNSVGFLLRPFNFFPED
650 660 670 680 690 700
720 730 740 750 760
pF1KE5 PSFYSADSIYFRGDQDAGACEVNPLACLPQAAACA-PDLPAFSHGGFSHN
::. : :.. .: : :. .:. :. : : ::..:
XP_016 PSLASRDTVIVW-PRDNGPNYVQRW--IPEDRDCSMP--PPFSYNGTYRPV
710 720 730 740 750
>>XP_016867435 (OMIM: 104610) PREDICTED: amiloride-sensi (770 aa)
initn: 1700 init1: 490 opt: 907 Z-score: 969.8 bits: 190.2 E(85289): 2.8e-47
Smith-Waterman score: 1802; 39.1% identity (64.4% similar) in 755 aa overlap (46-759:21-765)
20 30 40 50 60 70
pF1KE5 TIFALVCVLLVGRGGDGGEPSQLPHCPSVSPSAQPWTHPGQSQLFADLSREELTAVMRFL
:: : : : .. .:.::: .:: :: ::
XP_016 MPALGWAVAAILMLQTAMAEPS--PGTLPRKAGVFSDLSNQELKAVHSFL
10 20 30 40
80 90 100 110 120 130
pF1KE5 TQRLGPGLVDAAQARPSDNCVFSVELQLPPKAAALAHLDRGSPPPAREALAIVFFGRQPQ
.. : .. . . : :: .:. :: : .: ::.: :.::: :..::: : .
XP_016 WSKKELRLQPSSTTTMAKNTVFLIEMLLPKKYHVLRFLDKGERHPVREARAVIFFGDQEH
50 60 70 80 90 100
140 150 160 170 180 190
pF1KE5 PNVSELVVGPLPHPSYMRDVTVERHGGPLPYHRRPVLFQEYLDIDQMIFNRELPQASGLL
:::.:..::::: : ::: .. : : . ::. :: . . . . : . .:
XP_016 PNVTEFAVGPLPGPCYMRALS-PRPGYQSSWASRPISTAEYALLYHTLQEATKPLHQFFL
110 120 130 140 150 160
200 210 220 230 240 250
pF1KE5 HHC--CFYKHRGRNLVTMTTAPRGLQSGDRATWFGLYYNISGAGFFLHHVGLELLVNHKA
. : . : :. .::::. ::.: .:. . . :.::: .::::::.: .
XP_016 NTTGFSFQDCHDRCLAFTDVAPRGVASGQRRSWLIIQRYVE--GYFLHPTGLELLVDHGS
170 180 190 200 210 220
260 270 280 290 300
pF1KE5 LDPARWTIQKVFYQGRYYDSLAQLEAQFEAGLVNVVLIPDNGTGGSWSLKSPVPP-----
: ..:....:.:.:..: : .: .. : :.::.. : ::. .. ::
XP_016 TDAGHWAVEQVWYNGKFYGSPEELARKYADGEVDVVVLEDPLPGGKGHDSTEEPPLFSSH
230 240 250 260 270 280
310 320 330 340 350
pF1KE5 ---G--PAP-----PLQFYPQGPRFSVQGSRVASSLWTFSFGLGAFSGPRIFDVRFQGER
: :.: : :.:::: ..:. : . :.:.: : . :: ....:.: :::
XP_016 KPRGDFPSPIHVSGPRLVQPHGPRFRLEGNAVLYGGWSFAFRLRSSSGLQVLNVHFGGER
290 300 310 320 330 340
360 370 380 390 400 410
pF1KE5 LVYEISLQEALAIYGGNSPAAMTTRYVDGGFGMGKYTTPLTRGVDCPYLATYVDWHFLLE
..::.:.:::.:.:::..::.: :.:.: :.:.:. : :. :.::: ::..: .
XP_016 IAYEVSVQEAVALYGGHTPAGMQTKYLDVGWGLGSVTHELAPGIDCPETATFLDTFHYYD
350 360 370 380 390 400
420 430 440 450 460 470
pF1KE5 SQAPKTIRDAFCVFEQNQGLPLRRHHSDLYS---HYFGGLAETVLVVRSMSTLLNYDYVW
.. : :.:.::. :.::::: .. .. ....:: :::.:. ::. ::::.:
XP_016 ADDPVHYPRALCLFEMPTGVPLRRHFNSNFKGGFNFYAGLKGQVLVLRTTSTVYNYDYIW
410 420 430 440 450 460
480 490 500 510 520 530
pF1KE5 DTVFHPSGAIEIRFYATGYISSAFLFGATGKYGNQVSEHTLGTVHTHSAHFKVDLDVAGL
: .:.:.:..: ...::::. ..: ..:... : .:..::: .:..:::::::
XP_016 DFIFYPNGVMEAKMHATGYVHATFYTPEGLRHGTRLHTHLIGNIHTHLVHYRVDLDVAGT
470 480 490 500 510 520
540 550 560 570 580 590
pF1KE5 ENWVWAEDMVFVPMAVPWSPEHQLQRLQVTRKLLEMEEQAAFLVGSATPRYLYLASNHSN
.: . .: . .. ::::.:.. . . . :.:::: :.:: ..: . :
XP_016 KNSFQTLQMKLENITNPWSPRHRVVQPTLEQTQYSWERQAAFRFKRKLPKYLLFTSPQEN
530 540 550 560 570 580
600 610 620 630
pF1KE5 KWGHPRGYRIQMLSFAGEPLPQNSSMARGFSWER-------------------YQLAVTQ
::: : ::.:. :.: . :: . . ....: : : ::::.
XP_016 PWGHKRTYRLQIHSMADQVLPPGWQEEQAITWARTEGGQPRALSQAASPVPGRYPLAVTK
590 600 610 620 630 640
640 650 660 670 680 690
pF1KE5 RKEEEPSSSSVFNQNDPWAPTVDFSDFI-NNETIAGKDLVAWVTAGFLHIPHAEDIPNTV
.: : :::...::::: : : : .:. :::.: ..:::::::.:::::::.::::::.
XP_016 YRESELCSSSIYHQNDPWHPPVVFEQFLHNNENIENEDLVAWVTVGFLHIPHSEDIPNTA
650 660 670 680 690 700
700 710 720 730 740 750
pF1KE5 TVGNGVGFFLRPYNFFDEDPSFYSADSIYFRGDQDAGACEVNPLACLPQAAACA-PDLPA
: ::.:::.:::.::: ::::. : :.. .: : :. .:. :. : :
XP_016 TPGNSVGFLLRPFNFFPEDPSLASRDTVIVW-PRDNGPNYVQRW--IPEDRDCSMP--PP
710 720 730 740 750 760
760
pF1KE5 FSHGGFSHN
::..:
XP_016 FSYNGTYRPV
770
763 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 06:38:24 2016 done: Tue Nov 8 06:38:26 2016
Total Scan time: 11.530 Total Display time: 0.170
Function used was FASTA [36.3.4 Apr, 2011]