FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE1775, 282 aa 1>>>pF1KE1775 282 - 282 aa - 282 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.5064+/-0.000297; mu= 15.0932+/- 0.019 mean_var=78.0973+/-15.878, 0's: 0 Z-trim(118.3): 7 B-trim: 0 in 0/53 Lambda= 0.145130 statistics sampled from 31074 (31081) to 31074 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.726), E-opt: 0.2 (0.364), width: 16 Scan time: 7.790 The best scores are: opt bits E(85289) NP_002677 (OMIM: 171190) phenylethanolamine N-meth ( 282) 1928 412.6 4.3e-115 XP_011523211 (OMIM: 171190) PREDICTED: phenylethan ( 184) 1250 270.5 1.6e-72 NP_006765 (OMIM: 604854) indolethylamine N-methylt ( 263) 602 134.9 1.5e-31 NP_001186148 (OMIM: 604854) indolethylamine N-meth ( 262) 593 133.0 5.6e-31 NP_006160 (OMIM: 600008) nicotinamide N-methyltran ( 264) 592 132.8 6.5e-31 >>NP_002677 (OMIM: 171190) phenylethanolamine N-methyltr (282 aa) initn: 1928 init1: 1928 opt: 1928 Z-score: 2187.3 bits: 412.6 E(85289): 4.3e-115 Smith-Waterman score: 1928; 100.0% identity (100.0% similar) in 282 aa overlap (1-282:1-282) 10 20 30 40 50 60 pF1KE1 MSGADRSPNAGAAPDSAPGQAAVASAYQRFEPRAYLRNNYAPPRGDLCNPNGVGPWKLRC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 MSGADRSPNAGAAPDSAPGQAAVASAYQRFEPRAYLRNNYAPPRGDLCNPNGVGPWKLRC 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 LAQTFATGEVSGRTLIDIGSGPTVYQLLSACSHFEDITMTDFLEVNRQELGRWLQEEPGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 LAQTFATGEVSGRTLIDIGSGPTVYQLLSACSHFEDITMTDFLEVNRQELGRWLQEEPGA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 FNWSMYSQHACLIEGKGECWQDKERQLRARVKRVLPIDVHQPQPLGAGSPAPLPADALVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 FNWSMYSQHACLIEGKGECWQDKERQLRARVKRVLPIDVHQPQPLGAGSPAPLPADALVS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 AFCLEAVSPDLASFQRALDHITTLLRPGGHLLLIGALEESWYLAGEARLTVVPVSEEEVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 AFCLEAVSPDLASFQRALDHITTLLRPGGHLLLIGALEESWYLAGEARLTVVPVSEEEVR 190 200 210 220 230 240 250 260 270 280 pF1KE1 EALVRSGYKVRDLRTYIMPAHLQTGVDDVKGVFFAWAQKVGL :::::::::::::::::::::::::::::::::::::::::: NP_002 EALVRSGYKVRDLRTYIMPAHLQTGVDDVKGVFFAWAQKVGL 250 260 270 280 >>XP_011523211 (OMIM: 171190) PREDICTED: phenylethanolam (184 aa) initn: 1250 init1: 1250 opt: 1250 Z-score: 1422.8 bits: 270.5 E(85289): 1.6e-72 Smith-Waterman score: 1250; 100.0% identity (100.0% similar) in 184 aa overlap (99-282:1-184) 70 80 90 100 110 120 pF1KE1 EVSGRTLIDIGSGPTVYQLLSACSHFEDITMTDFLEVNRQELGRWLQEEPGAFNWSMYSQ :::::::::::::::::::::::::::::: XP_011 MTDFLEVNRQELGRWLQEEPGAFNWSMYSQ 10 20 30 130 140 150 160 170 180 pF1KE1 HACLIEGKGECWQDKERQLRARVKRVLPIDVHQPQPLGAGSPAPLPADALVSAFCLEAVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HACLIEGKGECWQDKERQLRARVKRVLPIDVHQPQPLGAGSPAPLPADALVSAFCLEAVS 40 50 60 70 80 90 190 200 210 220 230 240 pF1KE1 PDLASFQRALDHITTLLRPGGHLLLIGALEESWYLAGEARLTVVPVSEEEVREALVRSGY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PDLASFQRALDHITTLLRPGGHLLLIGALEESWYLAGEARLTVVPVSEEEVREALVRSGY 100 110 120 130 140 150 250 260 270 280 pF1KE1 KVRDLRTYIMPAHLQTGVDDVKGVFFAWAQKVGL :::::::::::::::::::::::::::::::::: XP_011 KVRDLRTYIMPAHLQTGVDDVKGVFFAWAQKVGL 160 170 180 >>NP_006765 (OMIM: 604854) indolethylamine N-methyltrans (263 aa) initn: 566 init1: 429 opt: 602 Z-score: 687.3 bits: 134.9 E(85289): 1.5e-31 Smith-Waterman score: 602; 39.2% identity (70.6% similar) in 255 aa overlap (27-279:11-259) 10 20 30 40 50 pF1KE1 MSGADRSPNAGAAPDSAPGQAAVASAYQR-FEPRAYLRNNYAPPRGDLCNPNGVGPWKLR ::. : :: :: . :. :. . ..:. NP_006 MKGGFTGGDEYQKHFLPRDYLATYYSFD-GSPSPEAEMLKFNLE 10 20 30 40 60 70 80 90 100 110 pF1KE1 CLAQTFATGEVSGRTLIDIGSGPTVYQLLSACSHFEDITMTDFLEVNRQELGRWLQEEPG :: .::. : ..: ::::::::::.::.:.::. :.:::..:: . ::.:: .::..::: NP_006 CLHKTFGPGGLQGDTLIDIGSGPTIYQVLAACDSFQDITLSDFTDRNREELEKWLKKEPG 50 60 70 80 90 100 120 130 140 150 160 170 pF1KE1 AFNWSMYSQHACLIEGKGECWQDKERQLRARVKRVLPIDVHQPQPLGAGSPAPLP-ADAL :..:. . :: .::.. :..::..::: ::::: ::: .:: .:: :: :: . NP_006 AYDWTPAVKFACELEGNSGRWEEKEEKLRAAVKRVLKCDVHLGNPL---APAVLPLADCV 110 120 130 140 150 160 180 190 200 210 220 230 pF1KE1 VSAFCLEAVSPDLASFQRALDHITTLLRPGGHLLLIGALEESWYLAGEARLTVVPVSEEE .. . .: . .: ... :: ....::.:::::. .:. :..:. ... : . .:: NP_006 LTLLAMECACCSLDAYRAALCNLASLLKPGGHLVTTVTLRLPSYMVGKREFSCVALEKEE 170 180 190 200 210 220 240 250 260 270 280 pF1KE1 VREALVRSGYKVRDLRTYIMPAHLQTGVDDVKGVFFAWAQKVGL :..:.. .:. ...: . . ..... :: : :.: NP_006 VEQAVLDAGFDIEQLLHSPQSYSVTNAANN--GVCFIVARKKPGP 230 240 250 260 >>NP_001186148 (OMIM: 604854) indolethylamine N-methyltr (262 aa) initn: 525 init1: 388 opt: 593 Z-score: 677.1 bits: 133.0 E(85289): 5.6e-31 Smith-Waterman score: 593; 39.2% identity (70.6% similar) in 255 aa overlap (27-279:11-258) 10 20 30 40 50 pF1KE1 MSGADRSPNAGAAPDSAPGQAAVASAYQR-FEPRAYLRNNYAPPRGDLCNPNGVGPWKLR ::. : :: :: . :. :. . ..:. NP_001 MKGGFTGGDEYQKHFLPRDYLATYYSFD-GSPSPEAEMLKFNLE 10 20 30 40 60 70 80 90 100 110 pF1KE1 CLAQTFATGEVSGRTLIDIGSGPTVYQLLSACSHFEDITMTDFLEVNRQELGRWLQEEPG :: .::. : ..: ::::::::::.::.:.::. :.:::..:: . ::.:: .::..::: NP_001 CLHKTFGPG-LQGDTLIDIGSGPTIYQVLAACDSFQDITLSDFTDRNREELEKWLKKEPG 50 60 70 80 90 100 120 130 140 150 160 170 pF1KE1 AFNWSMYSQHACLIEGKGECWQDKERQLRARVKRVLPIDVHQPQPLGAGSPAPLP-ADAL :..:. . :: .::.. :..::..::: ::::: ::: .:: .:: :: :: . NP_001 AYDWTPAVKFACELEGNSGRWEEKEEKLRAAVKRVLKCDVHLGNPL---APAVLPLADCV 110 120 130 140 150 180 190 200 210 220 230 pF1KE1 VSAFCLEAVSPDLASFQRALDHITTLLRPGGHLLLIGALEESWYLAGEARLTVVPVSEEE .. . .: . .: ... :: ....::.:::::. .:. :..:. ... : . .:: NP_001 LTLLAMECACCSLDAYRAALCNLASLLKPGGHLVTTVTLRLPSYMVGKREFSCVALEKEE 160 170 180 190 200 210 240 250 260 270 280 pF1KE1 VREALVRSGYKVRDLRTYIMPAHLQTGVDDVKGVFFAWAQKVGL :..:.. .:. ...: . . ..... :: : :.: NP_001 VEQAVLDAGFDIEQLLHSPQSYSVTNAANN--GVCFIVARKKPGP 220 230 240 250 260 >>NP_006160 (OMIM: 600008) nicotinamide N-methyltransfer (264 aa) initn: 583 init1: 345 opt: 592 Z-score: 675.9 bits: 132.8 E(85289): 6.5e-31 Smith-Waterman score: 592; 39.7% identity (68.7% similar) in 252 aa overlap (30-280:15-260) 10 20 30 40 50 pF1KE1 MSGADRSPNAGAAPDSAPGQAAVASAYQRFEPRAYLRNNYAPPRGDLCNPNG-VGPWKLR :.:: ::.. : :. . .. . :. NP_006 MESGFTSKDTYLSHFNPRDYLEKYY--KFGSRHSAESQILKHLLK 10 20 30 40 60 70 80 90 100 110 pF1KE1 CLAQTFATGEVSGRTLIDIGSGPTVYQLLSACSHFEDITMTDFLEVNRQELGRWLQEEPG : . : :.: :::::::::.::::::: :..:..::. . : ::: .::..:: NP_006 NLFKIFCLDGVKGDLLIDIGSGPTIYQLLSACESFKEIVVTDYSDQNLQELEKWLKKEPE 50 60 70 80 90 100 120 130 140 150 160 170 pF1KE1 AFNWSMYSQHACLIEGKGECWQDKERQLRARVKRVLPIDVHQPQPLGAGSPAPLPADALV ::.:: ..: .::. .::..:: ::.:: :: : ::::: : : ::: .. NP_006 AFDWSPVVTYVCDLEGNRVKGPEKEEKLRQAVKQVLKCDVTQSQPLGA-VPLP-PADCVL 110 120 130 140 150 160 180 190 200 210 220 230 pF1KE1 SAFCLEAVSPDLASFQRALDHITTLLRPGGHLLLIGALEESWYLAGEARLTVVPVSEEEV :..::.:. ::: .. ::: .. .::.::: :... ::. :.:. :: ... .:...: : NP_006 STLCLDAACPDLPTYCRALRNLGSLLKPGGFLVIMDALKSSYYMIGEQKFSSLPLGREAV 170 180 190 200 210 220 240 250 260 270 280 pF1KE1 REALVRSGYKVRDLRTYIMPAHLQTGVDDVKGVFFAWAQKVGL . :. ..:: .. .. .. .. . . .:.: :.:. NP_006 EAAVKEAGYTIEWFE--VISQSYSSTMANNEGLFSLVARKLSRPL 230 240 250 260 282 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 13:51:02 2016 done: Sun Nov 6 13:51:04 2016 Total Scan time: 7.790 Total Display time: -0.010 Function used was FASTA [36.3.4 Apr, 2011]