FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE6637, 215 aa 1>>>pF1KE6637 215 - 215 aa - 215 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.0981+/-0.000318; mu= 14.4249+/- 0.020 mean_var=56.1974+/-11.208, 0's: 0 Z-trim(115.3): 31 B-trim: 104 in 1/54 Lambda= 0.171087 statistics sampled from 25693 (25724) to 25693 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.688), E-opt: 0.2 (0.302), width: 16 Scan time: 4.940 The best scores are: opt bits E(85289) NP_005199 (OMIM: 123610,600881) beta-crystallin A3 ( 215) 1537 387.1 1.2e-107 XP_016879687 (OMIM: 123610,600881) PREDICTED: beta ( 316) 1476 372.1 5.5e-103 NP_001877 (OMIM: 123631,610425) beta-crystallin A4 ( 196) 1002 255.0 6e-68 XP_006724203 (OMIM: 123631,610425) PREDICTED: beta ( 201) 1002 255.0 6.2e-68 XP_016884087 (OMIM: 123631,610425) PREDICTED: beta ( 207) 1002 255.1 6.3e-68 NP_476434 (OMIM: 115900,600836) beta-crystallin A2 ( 197) 788 202.2 4.8e-52 NP_476435 (OMIM: 115900,600836) beta-crystallin A2 ( 197) 788 202.2 4.8e-52 XP_011528201 (OMIM: 600929,611544) PREDICTED: beta ( 252) 659 170.4 2.3e-42 NP_001878 (OMIM: 600929,611544) beta-crystallin B1 ( 252) 659 170.4 2.3e-42 XP_006724204 (OMIM: 123620,601547) PREDICTED: beta ( 205) 579 150.6 1.7e-36 XP_011528202 (OMIM: 123620,601547) PREDICTED: beta ( 205) 579 150.6 1.7e-36 NP_000487 (OMIM: 123620,601547) beta-crystallin B2 ( 205) 579 150.6 1.7e-36 NP_004067 (OMIM: 123630,609741) beta-crystallin B3 ( 211) 578 150.4 2.1e-36 XP_011528204 (OMIM: 123630,609741) PREDICTED: beta ( 267) 579 150.7 2.1e-36 XP_005250009 (OMIM: 609603) PREDICTED: gamma-cryst ( 182) 449 118.5 6.9e-27 XP_011514138 (OMIM: 609603) PREDICTED: gamma-cryst ( 295) 449 118.6 1.1e-26 XP_016858891 (OMIM: 123670,615188) PREDICTED: gamm ( 177) 376 100.5 1.8e-21 NP_066269 (OMIM: 123680,604307) gamma-crystallin C ( 174) 371 99.3 4.2e-21 XP_011508964 (OMIM: 123680,604307) PREDICTED: gamm ( 174) 371 99.3 4.2e-21 NP_060011 (OMIM: 116100,123730) beta-crystallin S ( 178) 370 99.0 5e-21 XP_011514139 (OMIM: 609603) PREDICTED: gamma-cryst ( 260) 370 99.1 7e-21 NP_008822 (OMIM: 115700,123690) gamma-crystallin D ( 174) 363 97.3 1.6e-20 NP_653328 (OMIM: 609603) gamma-crystallin N isofor ( 182) 353 94.8 9.4e-20 NP_005201 (OMIM: 123670,615188) gamma-crystallin B ( 175) 348 93.6 2.1e-19 XP_016884088 (OMIM: 123630,609741) PREDICTED: beta ( 169) 331 89.4 3.8e-18 NP_055432 (OMIM: 123660) gamma-crystallin A [Homo ( 174) 322 87.2 1.8e-17 XP_016865822 (OMIM: 601797) PREDICTED: absent in m (1544) 302 82.6 3.7e-15 NP_001615 (OMIM: 601797) absent in melanoma 1 prot (1723) 302 82.7 4.1e-15 XP_005266896 (OMIM: 601797) PREDICTED: absent in m (2131) 302 82.7 5e-15 XP_016867262 (OMIM: 609603) PREDICTED: gamma-cryst ( 125) 251 69.6 2.6e-12 NP_001295221 (OMIM: 609603) gamma-crystallin N iso ( 125) 251 69.6 2.6e-12 >>NP_005199 (OMIM: 123610,600881) beta-crystallin A3 [Ho (215 aa) initn: 1537 init1: 1537 opt: 1537 Z-score: 2053.9 bits: 387.1 E(85289): 1.2e-107 Smith-Waterman score: 1537; 100.0% identity (100.0% similar) in 215 aa overlap (1-215:1-215) 10 20 30 40 50 60 pF1KE6 METQAEQQELETLPTTKMAQTNPTPGSLGPWKITIYDQENFQGKRMEFTSSCPNVSERSF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 METQAEQQELETLPTTKMAQTNPTPGSLGPWKITIYDQENFQGKRMEFTSSCPNVSERSF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 DNVRSLKVESGAWIGYEHTSFCGQQFILERGEYPRWDAWSGSNAYHIERLMSFRPICSAN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 DNVRSLKVESGAWIGYEHTSFCGQQFILERGEYPRWDAWSGSNAYHIERLMSFRPICSAN 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 HKESKMTIFEKENFIGRQWEISDDYPSLQAMGWFNNEVGSMKIQSGAWVCYQYPGYRGYQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 HKESKMTIFEKENFIGRQWEISDDYPSLQAMGWFNNEVGSMKIQSGAWVCYQYPGYRGYQ 130 140 150 160 170 180 190 200 210 pF1KE6 YILECDHHGGDYKHWREWGSHAQTSQIQSIRRIQQ ::::::::::::::::::::::::::::::::::: NP_005 YILECDHHGGDYKHWREWGSHAQTSQIQSIRRIQQ 190 200 210 >>XP_016879687 (OMIM: 123610,600881) PREDICTED: beta-cry (316 aa) initn: 1523 init1: 1476 opt: 1476 Z-score: 1969.9 bits: 372.1 E(85289): 5.5e-103 Smith-Waterman score: 1476; 100.0% identity (100.0% similar) in 205 aa overlap (11-215:112-316) 10 20 30 40 pF1KE6 METQAEQQELETLPTTKMAQTNPTPGSLGPWKITIYDQEN :::::::::::::::::::::::::::::: XP_016 RLQVSFTFQGIPSPPPPPKRPHHSCVLCLPETLPTTKMAQTNPTPGSLGPWKITIYDQEN 90 100 110 120 130 140 50 60 70 80 90 100 pF1KE6 FQGKRMEFTSSCPNVSERSFDNVRSLKVESGAWIGYEHTSFCGQQFILERGEYPRWDAWS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FQGKRMEFTSSCPNVSERSFDNVRSLKVESGAWIGYEHTSFCGQQFILERGEYPRWDAWS 150 160 170 180 190 200 110 120 130 140 150 160 pF1KE6 GSNAYHIERLMSFRPICSANHKESKMTIFEKENFIGRQWEISDDYPSLQAMGWFNNEVGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GSNAYHIERLMSFRPICSANHKESKMTIFEKENFIGRQWEISDDYPSLQAMGWFNNEVGS 210 220 230 240 250 260 170 180 190 200 210 pF1KE6 MKIQSGAWVCYQYPGYRGYQYILECDHHGGDYKHWREWGSHAQTSQIQSIRRIQQ ::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MKIQSGAWVCYQYPGYRGYQYILECDHHGGDYKHWREWGSHAQTSQIQSIRRIQQ 270 280 290 300 310 >>NP_001877 (OMIM: 123631,610425) beta-crystallin A4 [Ho (196 aa) initn: 1002 init1: 1002 opt: 1002 Z-score: 1340.8 bits: 255.0 E(85289): 6e-68 Smith-Waterman score: 1002; 68.3% identity (89.9% similar) in 189 aa overlap (27-215:8-196) 10 20 30 40 50 60 pF1KE6 METQAEQQELETLPTTKMAQTNPTPGSLGPWKITIYDQENFQGKRMEFTSSCPNVSERSF : ::::....:...:::.: :::. ::.: : .: NP_001 MTLQCTKSAGPWKMVVWDEDGFQGRRHEFTAECPSVLELGF 10 20 30 40 70 80 90 100 110 120 pF1KE6 DNVRSLKVESGAWIGYEHTSFCGQQFILERGEYPRWDAWSGSNAYHIERLMSFRPICSAN ..:::::: ::::.:.::..: :::.:::::::: ::::.:..:: ::: :::: :: NP_001 ETVRSLKVLSGAWVGFEHAGFQGQQYILERGEYPSWDAWGGNTAYPAERLTSFRPAACAN 50 60 70 80 90 100 130 140 150 160 170 180 pF1KE6 HKESKMTIFEKENFIGRQWEISDDYPSLQAMGWFNNEVGSMKIQSGAWVCYQYPGYRGYQ :..:..::::.:::.:.. :.:::::::::::: .:::::....:::::: :.:::::.: NP_001 HRDSRLTIFEQENFLGKKGELSDDYPSLQAMGWEGNEVGSFHVHSGAWVCSQFPGYRGFQ 110 120 130 140 150 160 190 200 210 pF1KE6 YILECDHHGGDYKHWREWGSHAQTSQIQSIRRIQQ :.::::::.:::::.::::::: : :.:::::::: NP_001 YVLECDHHSGDYKHFREWGSHAPTFQVQSIRRIQQ 170 180 190 >>XP_006724203 (OMIM: 123631,610425) PREDICTED: beta-cry (201 aa) initn: 1002 init1: 1002 opt: 1002 Z-score: 1340.7 bits: 255.0 E(85289): 6.2e-68 Smith-Waterman score: 1002; 68.3% identity (89.9% similar) in 189 aa overlap (27-215:13-201) 10 20 30 40 50 60 pF1KE6 METQAEQQELETLPTTKMAQTNPTPGSLGPWKITIYDQENFQGKRMEFTSSCPNVSERSF : ::::....:...:::.: :::. ::.: : .: XP_006 MEGATMTLQCTKSAGPWKMVVWDEDGFQGRRHEFTAECPSVLELGF 10 20 30 40 70 80 90 100 110 120 pF1KE6 DNVRSLKVESGAWIGYEHTSFCGQQFILERGEYPRWDAWSGSNAYHIERLMSFRPICSAN ..:::::: ::::.:.::..: :::.:::::::: ::::.:..:: ::: :::: :: XP_006 ETVRSLKVLSGAWVGFEHAGFQGQQYILERGEYPSWDAWGGNTAYPAERLTSFRPAACAN 50 60 70 80 90 100 130 140 150 160 170 180 pF1KE6 HKESKMTIFEKENFIGRQWEISDDYPSLQAMGWFNNEVGSMKIQSGAWVCYQYPGYRGYQ :..:..::::.:::.:.. :.:::::::::::: .:::::....:::::: :.:::::.: XP_006 HRDSRLTIFEQENFLGKKGELSDDYPSLQAMGWEGNEVGSFHVHSGAWVCSQFPGYRGFQ 110 120 130 140 150 160 190 200 210 pF1KE6 YILECDHHGGDYKHWREWGSHAQTSQIQSIRRIQQ :.::::::.:::::.::::::: : :.:::::::: XP_006 YVLECDHHSGDYKHFREWGSHAPTFQVQSIRRIQQ 170 180 190 200 >>XP_016884087 (OMIM: 123631,610425) PREDICTED: beta-cry (207 aa) initn: 1002 init1: 1002 opt: 1002 Z-score: 1340.5 bits: 255.1 E(85289): 6.3e-68 Smith-Waterman score: 1002; 68.3% identity (89.9% similar) in 189 aa overlap (27-215:19-207) 10 20 30 40 50 60 pF1KE6 METQAEQQELETLPTTKMAQTNPTPGSLGPWKITIYDQENFQGKRMEFTSSCPNVSERSF : ::::....:...:::.: :::. ::.: : .: XP_016 MFPGPISEGATMTLQCTKSAGPWKMVVWDEDGFQGRRHEFTAECPSVLELGF 10 20 30 40 50 70 80 90 100 110 120 pF1KE6 DNVRSLKVESGAWIGYEHTSFCGQQFILERGEYPRWDAWSGSNAYHIERLMSFRPICSAN ..:::::: ::::.:.::..: :::.:::::::: ::::.:..:: ::: :::: :: XP_016 ETVRSLKVLSGAWVGFEHAGFQGQQYILERGEYPSWDAWGGNTAYPAERLTSFRPAACAN 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE6 HKESKMTIFEKENFIGRQWEISDDYPSLQAMGWFNNEVGSMKIQSGAWVCYQYPGYRGYQ :..:..::::.:::.:.. :.:::::::::::: .:::::....:::::: :.:::::.: XP_016 HRDSRLTIFEQENFLGKKGELSDDYPSLQAMGWEGNEVGSFHVHSGAWVCSQFPGYRGFQ 120 130 140 150 160 170 190 200 210 pF1KE6 YILECDHHGGDYKHWREWGSHAQTSQIQSIRRIQQ :.::::::.:::::.::::::: : :.:::::::: XP_016 YVLECDHHSGDYKHFREWGSHAPTFQVQSIRRIQQ 180 190 200 >>NP_476434 (OMIM: 115900,600836) beta-crystallin A2 [Ho (197 aa) initn: 907 init1: 677 opt: 788 Z-score: 1055.3 bits: 202.2 E(85289): 4.8e-52 Smith-Waterman score: 788; 53.1% identity (85.7% similar) in 196 aa overlap (21-215:3-197) 10 20 30 40 50 pF1KE6 METQAEQQELETLPTTKMAQTNPTPGSLGPWKITIYDQENFQGKRMEFTSSCPNVSERS- . :.:: .: ..:..:.:.:::.: .. :.: :: ::. NP_476 MSSAPAPGP-APASLTLWDEEDFQGRRCRLLSDCANVCERGG 10 20 30 40 60 70 80 90 100 110 pF1KE6 FDNVRSLKVESGAWIGYEHTSFCGQQFILERGEYPRWDAWSGSNAYHIERLMSFRPICSA . :::.:::.:.:...:. .: :::::::.:.::::.:::::.... ..:.::::. : NP_476 LPRVRSVKVENGVWVAFEYPDFQGQQFILEKGDYPRWSAWSGSSSHNSNQLLSFRPVLCA 50 60 70 80 90 100 120 130 140 150 160 170 pF1KE6 NHKESKMTIFEKENFIGRQWEISDDYPSLQAMGWFNNEVGSMKIQSGAWVCYQYPGYRGY ::..:..:.:: .:: : .... :::::: .::: ...:::.:..::::: ::::::::: NP_476 NHNDSRVTLFEGDNFQGCKFDLVDDYPSLPSMGWASKDVGSLKVSSGAWVAYQYPGYRGY 110 120 130 140 150 160 180 190 200 210 pF1KE6 QYILECDHHGGDYKHWREWGSHAQTSQIQSIRRIQQ ::.:: :.:.:.. . : :..:.:.:.:::::.:. NP_476 QYVLERDRHSGEFCTYGELGTQAHTGQLQSIRRVQH 170 180 190 >>NP_476435 (OMIM: 115900,600836) beta-crystallin A2 [Ho (197 aa) initn: 907 init1: 677 opt: 788 Z-score: 1055.3 bits: 202.2 E(85289): 4.8e-52 Smith-Waterman score: 788; 53.1% identity (85.7% similar) in 196 aa overlap (21-215:3-197) 10 20 30 40 50 pF1KE6 METQAEQQELETLPTTKMAQTNPTPGSLGPWKITIYDQENFQGKRMEFTSSCPNVSERS- . :.:: .: ..:..:.:.:::.: .. :.: :: ::. NP_476 MSSAPAPGP-APASLTLWDEEDFQGRRCRLLSDCANVCERGG 10 20 30 40 60 70 80 90 100 110 pF1KE6 FDNVRSLKVESGAWIGYEHTSFCGQQFILERGEYPRWDAWSGSNAYHIERLMSFRPICSA . :::.:::.:.:...:. .: :::::::.:.::::.:::::.... ..:.::::. : NP_476 LPRVRSVKVENGVWVAFEYPDFQGQQFILEKGDYPRWSAWSGSSSHNSNQLLSFRPVLCA 50 60 70 80 90 100 120 130 140 150 160 170 pF1KE6 NHKESKMTIFEKENFIGRQWEISDDYPSLQAMGWFNNEVGSMKIQSGAWVCYQYPGYRGY ::..:..:.:: .:: : .... :::::: .::: ...:::.:..::::: ::::::::: NP_476 NHNDSRVTLFEGDNFQGCKFDLVDDYPSLPSMGWASKDVGSLKVSSGAWVAYQYPGYRGY 110 120 130 140 150 160 180 190 200 210 pF1KE6 QYILECDHHGGDYKHWREWGSHAQTSQIQSIRRIQQ ::.:: :.:.:.. . : :..:.:.:.:::::.:. NP_476 QYVLERDRHSGEFCTYGELGTQAHTGQLQSIRRVQH 170 180 190 >>XP_011528201 (OMIM: 600929,611544) PREDICTED: beta-cry (252 aa) initn: 573 init1: 309 opt: 659 Z-score: 881.6 bits: 170.4 E(85289): 2.3e-42 Smith-Waterman score: 676; 48.5% identity (77.0% similar) in 204 aa overlap (12-214:43-233) 10 20 30 40 pF1KE6 METQAEQQELETLPTTKMAQTNPTPGSLGPWKITIYDQENF :.: :. .. ::. ....... ::: XP_011 VAVNPGPDTKGKGAPPAGTSPSPGTTLAPTTVPITSAKAAELPPGN---YRLVVFELENF 20 30 40 50 60 50 60 70 80 90 100 pF1KE6 QGKRMEFTSSCPNVSERSFDNVRSLKVESGAWIGYEHTSFCGQQFILERGEYPRWDAWSG ::.: ::.. : :...:.:: :::. : .: :...:...: :..::::.::::::..::. XP_011 QGRRAEFSGECSNLADRGFDRVRSIIVSAGPWVAFEQSNFRGEMFILEKGEYPRWNTWSS 70 80 90 100 110 120 110 120 130 140 150 160 pF1KE6 SNAYHIERLMSFRPICSANHKESKMTIFEKENFIGRQWEIS-DDYPSLQAMGWFNNEVGS : :. .:::::::: . . .: :...:: :: : ::. :: ::: ..: :...::: XP_011 S--YRSDRLMSFRPI-KMDAQEHKISLFEGANFKGNTIEIQGDDAPSLWVYG-FSDRVGS 130 140 150 160 170 180 170 180 190 200 210 pF1KE6 MKIQSGAWVCYQYPGYRGYQYILECDHHGGDYKHWREWGSHAQTSQIQSIRRIQQ .:..::.:: :::::::::::.:: ::..:: ::: : :.::.::.. XP_011 VKVSSGTWVGYQYPGYRGYQYLLE----PGDFRHWNEWG--AFQPQMQSLRRLRDKQWHL 190 200 210 220 230 XP_011 EGSFPVLATEPPK 240 250 >>NP_001878 (OMIM: 600929,611544) beta-crystallin B1 [Ho (252 aa) initn: 573 init1: 309 opt: 659 Z-score: 881.6 bits: 170.4 E(85289): 2.3e-42 Smith-Waterman score: 676; 48.5% identity (77.0% similar) in 204 aa overlap (12-214:43-233) 10 20 30 40 pF1KE6 METQAEQQELETLPTTKMAQTNPTPGSLGPWKITIYDQENF :.: :. .. ::. ....... ::: NP_001 VAVNPGPDTKGKGAPPAGTSPSPGTTLAPTTVPITSAKAAELPPGN---YRLVVFELENF 20 30 40 50 60 50 60 70 80 90 100 pF1KE6 QGKRMEFTSSCPNVSERSFDNVRSLKVESGAWIGYEHTSFCGQQFILERGEYPRWDAWSG ::.: ::.. : :...:.:: :::. : .: :...:...: :..::::.::::::..::. NP_001 QGRRAEFSGECSNLADRGFDRVRSIIVSAGPWVAFEQSNFRGEMFILEKGEYPRWNTWSS 70 80 90 100 110 120 110 120 130 140 150 160 pF1KE6 SNAYHIERLMSFRPICSANHKESKMTIFEKENFIGRQWEIS-DDYPSLQAMGWFNNEVGS : :. .:::::::: . . .: :...:: :: : ::. :: ::: ..: :...::: NP_001 S--YRSDRLMSFRPI-KMDAQEHKISLFEGANFKGNTIEIQGDDAPSLWVYG-FSDRVGS 130 140 150 160 170 180 170 180 190 200 210 pF1KE6 MKIQSGAWVCYQYPGYRGYQYILECDHHGGDYKHWREWGSHAQTSQIQSIRRIQQ .:..::.:: :::::::::::.:: ::..:: ::: : :.::.::.. NP_001 VKVSSGTWVGYQYPGYRGYQYLLE----PGDFRHWNEWG--AFQPQMQSLRRLRDKQWHL 190 200 210 220 230 NP_001 EGSFPVLATEPPK 240 250 >>XP_006724204 (OMIM: 123620,601547) PREDICTED: beta-cry (205 aa) initn: 511 init1: 282 opt: 579 Z-score: 776.3 bits: 150.6 E(85289): 1.7e-36 Smith-Waterman score: 585; 46.1% identity (76.4% similar) in 191 aa overlap (25-214:12-191) 10 20 30 40 50 60 pF1KE6 METQAEQQELETLPTTKMAQTNPTPGSLGPWKITIYDQENFQGKRMEFTSSCPNVSERSF : ::.: :: :..::::::. :... :::..: . XP_006 MASDHQTQAGKPQSLNP-KIIIFEQENFQGHSHELNGPCPNLKETGV 10 20 30 40 70 80 90 100 110 120 pF1KE6 DNVRSLKVESGAWIGYEHTSFCGQQFILERGEYPRWDAWSGSNAYHIERLMSFRPICSAN ... :. :..: :.:::... :.::..:.:::::::.:..: . . : :.::: ... XP_006 EKAGSVLVQAGPWVGYEQANCKGEQFVFEKGEYPRWDSWTSS--RRTDSLSSLRPI-KVD 50 60 70 80 90 100 130 140 150 160 170 pF1KE6 HKESKMTIFEKENFIGRQWEI-SDDYPSLQAMGWFNNEVGSMKIQSGAWVCYQYPGYRGY .: :. ..:. :: :.. :: .:: ::..: : ....:.:...:::.:: :::::::: XP_006 SQEHKIILYENPNFTGKKMEIIDDDVPSFHAHG-YQEKVSSVRVQSGTWVGYQYPGYRGL 110 120 130 140 150 160 180 190 200 210 pF1KE6 QYILECDHHGGDYKHWREWGSHAQTSQIQSIRRIQQ ::.:: :::: ..: : :.::.:::. XP_006 QYLLE----KGDYKDSSDFG--APHPQVQSVRRIRDMQWHQRGAFHPSN 170 180 190 200 215 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 14:59:46 2016 done: Tue Nov 8 14:59:47 2016 Total Scan time: 4.940 Total Display time: -0.010 Function used was FASTA [36.3.4 Apr, 2011]