Result of FASTA (omim) for
pFN21AE2175
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE2175, 124 aa
1>>>pF1KE2175 124 - 124 aa - 124 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.3650+/-0.000366; mu= 4.7809+/- 0.022
mean_var=137.6763+/-29.214, 0's: 0 Z-trim(117.4): 200 B-trim: 308 in 1/50
Lambda= 0.109306
statistics sampled from 29179 (29434) to 29179 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.737), E-opt: 0.2 (0.345), width: 16
Scan time: 4.910
The best scores are: opt bits E(85289)
NP_055419 (OMIM: 616484) tax1-binding protein 3 is ( 124) 804 137.5 5.4e-33
NP_001191627 (OMIM: 616484) tax1-binding protein 3 ( 98) 355 66.6 9.5e-12
NP_001158067 (OMIM: 609730) PDZ domain-containing (1036) 213 45.2 0.00027
XP_016865126 (OMIM: 606944) PREDICTED: protein LAP (1298) 204 43.9 0.00085
NP_001006600 (OMIM: 606944) erbin isoform 7 [Homo (1302) 204 43.9 0.00085
NP_001240630 (OMIM: 606944) erbin isoform 9 [Homo (1367) 198 43.0 0.0017
NP_061165 (OMIM: 606944) erbin isoform 2 [Homo sap (1371) 198 43.0 0.0017
NP_001240626 (OMIM: 606944) erbin isoform 1 [Homo (1412) 198 43.0 0.0017
XP_016865125 (OMIM: 606944) PREDICTED: protein LAP (1415) 198 43.0 0.0017
NP_001240628 (OMIM: 606944) erbin isoform 8 [Homo (1419) 198 43.0 0.0017
XP_005248612 (OMIM: 606944) PREDICTED: protein LAP (1456) 198 43.0 0.0018
XP_016865124 (OMIM: 606944) PREDICTED: protein LAP (1460) 198 43.0 0.0018
XP_005248611 (OMIM: 606944) PREDICTED: protein LAP (1460) 198 43.0 0.0018
XP_016857375 (OMIM: 614453) PREDICTED: leucine-ric (1594) 195 42.6 0.0026
NP_001317564 (OMIM: 614453) leucine-rich repeat-co (1495) 191 41.9 0.0039
XP_016857379 (OMIM: 614453) PREDICTED: leucine-ric (1528) 191 41.9 0.0039
NP_065845 (OMIM: 614453) leucine-rich repeat-conta (1537) 191 41.9 0.0039
XP_016857376 (OMIM: 614453) PREDICTED: leucine-ric (1547) 191 41.9 0.004
XP_016857374 (OMIM: 614453) PREDICTED: leucine-ric (1594) 191 41.9 0.004
NP_060843 (OMIM: 609411) synaptojanin-2-binding pr ( 145) 172 37.9 0.0061
>>NP_055419 (OMIM: 616484) tax1-binding protein 3 isofor (124 aa)
initn: 804 init1: 804 opt: 804 Z-score: 713.3 bits: 137.5 E(85289): 5.4e-33
Smith-Waterman score: 804; 100.0% identity (100.0% similar) in 124 aa overlap (1-124:1-124)
10 20 30 40 50 60
pF1KE2 MSYIPGQPVTAVVQRVEIHKLRQGENLILGFSIGGGIDQDPSQNPFSEDKTDKGIYVTRV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 MSYIPGQPVTAVVQRVEIHKLRQGENLILGFSIGGGIDQDPSQNPFSEDKTDKGIYVTRV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 SEGGPAEIAGLQIGDKIMQVNGWDMTMVTHDQARKRLTKRSEEVVRLLVTRQSLQKAVQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 SEGGPAEIAGLQIGDKIMQVNGWDMTMVTHDQARKRLTKRSEEVVRLLVTRQSLQKAVQQ
70 80 90 100 110 120
pF1KE2 SMLS
::::
NP_055 SMLS
>>NP_001191627 (OMIM: 616484) tax1-binding protein 3 iso (98 aa)
initn: 355 init1: 355 opt: 355 Z-score: 331.9 bits: 66.6 E(85289): 9.5e-12
Smith-Waterman score: 575; 79.0% identity (79.0% similar) in 124 aa overlap (1-124:1-98)
10 20 30 40 50 60
pF1KE2 MSYIPGQPVTAVVQRVEIHKLRQGENLILGFSIGGGIDQDPSQNPFSEDKTDKGIYVTRV
:::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MSYIPGQPVTAVVQRVEIHKLRQGENLILGFSIGGGIDQDPSQNPFSEDKTDK-------
10 20 30 40 50
70 80 90 100 110 120
pF1KE2 SEGGPAEIAGLQIGDKIMQVNGWDMTMVTHDQARKRLTKRSEEVVRLLVTRQSLQKAVQQ
:::::::::::::::::::::::::::::::::::::::::
NP_001 -------------------VNGWDMTMVTHDQARKRLTKRSEEVVRLLVTRQSLQKAVQQ
60 70 80 90
pF1KE2 SMLS
::::
NP_001 SMLS
>>NP_001158067 (OMIM: 609730) PDZ domain-containing RING (1036 aa)
initn: 203 init1: 98 opt: 213 Z-score: 198.1 bits: 45.2 E(85289): 0.00027
Smith-Waterman score: 215; 38.7% identity (64.9% similar) in 111 aa overlap (7-116:221-318)
10 20 30
pF1KE2 MSYIPGQPVTAVVQRVEIHKLRQGENLILGFSIGGG
.: : :..: :: :::.: ::
NP_001 RYQEKFTQYMAHVRNFVGDLGGGHRRDGEHKPFTIVLER---------ENDTLGFNIIGG
200 210 220 230 240
40 50 60 70 80 90
pF1KE2 IDQDPSQNPFSEDKTDKGIYVTRVSEGGPAEIA-GLQIGDKIMQVNGWDMTMVTHDQARK
:.:: .: . .::::... :.:::. : ::.: ::::.::: :.. .::..: .
NP_001 ---RPNQNN-QEGTSTEGIYVSKILENGPADRADGLEIHDKIMEVNGKDLSKATHEEAVE
250 260 270 280 290
100 110 120
pF1KE2 RLTKRSEEVVRLLVTRQSLQKAVQQSMLS
. . .: .: .. : :..
NP_001 AFRNAKEPIVVQVLRRTPLSRPAYGMASEVQLMNASTQTDITFEHIMALAKLRPPTPPVP
300 310 320 330 340 350
>>XP_016865126 (OMIM: 606944) PREDICTED: protein LAP2 is (1298 aa)
initn: 171 init1: 83 opt: 204 Z-score: 189.2 bits: 43.9 E(85289): 0.00085
Smith-Waterman score: 204; 37.9% identity (63.8% similar) in 116 aa overlap (2-112:1186-1295)
10 20
pF1KE2 MSYIPGQPVTAVVQRVEIHKLRQGENLI---
: .: . :....: .::.. . .
XP_016 SDFNYSRTSPSKRPNARVGSEHSLLDPPGKSKVPRDWREQVLRHIEAKKLEKIRVRVEKD
1160 1170 1180 1190 1200 1210
30 40 50 60 70 80
pF1KE2 --LGFSIGGGIDQDPSQNPFSEDKTDKGIYVTRVSEGGPAEIAGLQIGDKIMQVNGWDMT
:::::.::. ::: : : ::.::::. ::: :: ::::.:.::...
XP_016 PELGFSISGGVG--GRGNPFRPD--DDGIFVTRVQPEGPAS-KLLQPGDKIIQANGYSFI
1220 1230 1240 1250 1260 1270
90 100 110 120
pF1KE2 MVTHDQARKRLTKRSEEVVRLLVTRQSLQKAVQQSMLS
. : :: . : : ...:.:...:.
XP_016 NIEHGQAVS-LLKTFQNTVELIIVREVSS
1280 1290
>>NP_001006600 (OMIM: 606944) erbin isoform 7 [Homo sapi (1302 aa)
initn: 171 init1: 83 opt: 204 Z-score: 189.2 bits: 43.9 E(85289): 0.00085
Smith-Waterman score: 204; 37.9% identity (63.8% similar) in 116 aa overlap (2-112:1190-1299)
10 20
pF1KE2 MSYIPGQPVTAVVQRVEIHKLRQGENLI---
: .: . :....: .::.. . .
NP_001 SDFNYSRTSPSKRPNARVGSEHSLLDPPGKSKVPRDWREQVLRHIEAKKLEKIRVRVEKD
1160 1170 1180 1190 1200 1210
30 40 50 60 70 80
pF1KE2 --LGFSIGGGIDQDPSQNPFSEDKTDKGIYVTRVSEGGPAEIAGLQIGDKIMQVNGWDMT
:::::.::. ::: : : ::.::::. ::: :: ::::.:.::...
NP_001 PELGFSISGGVG--GRGNPFRPD--DDGIFVTRVQPEGPAS-KLLQPGDKIIQANGYSFI
1220 1230 1240 1250 1260 1270
90 100 110 120
pF1KE2 MVTHDQARKRLTKRSEEVVRLLVTRQSLQKAVQQSMLS
. : :: . : : ...:.:...:.
NP_001 NIEHGQAVS-LLKTFQNTVELIIVREVSS
1280 1290 1300
>>NP_001240630 (OMIM: 606944) erbin isoform 9 [Homo sapi (1367 aa)
initn: 171 init1: 83 opt: 198 Z-score: 183.8 bits: 43.0 E(85289): 0.0017
Smith-Waterman score: 198; 38.9% identity (63.9% similar) in 108 aa overlap (5-112:1266-1364)
10 20 30
pF1KE2 MSYIPGQPVTAVVQRVEIHKLRQGENLILGFSIG
: : . :..... .. : :::::.
NP_001 VARHPSREQLIDYLMLKVAHQPPYTQPHCSPRQGHELAKQEIRVRVEKDPE---LGFSIS
1240 1250 1260 1270 1280 1290
40 50 60 70 80 90
pF1KE2 GGIDQDPSQNPFSEDKTDKGIYVTRVSEGGPAEIAGLQIGDKIMQVNGWDMTMVTHDQAR
::. ::: : : ::.::::. ::: :: ::::.:.::... . : ::
NP_001 GGVG--GRGNPFRPD--DDGIFVTRVQPEGPASKL-LQPGDKIIQANGYSFINIEHGQAV
1300 1310 1320 1330 1340
100 110 120
pF1KE2 KRLTKRSEEVVRLLVTRQSLQKAVQQSMLS
. : : ...:.:...:.
NP_001 S-LLKTFQNTVELIIVREVSS
1350 1360
>>NP_061165 (OMIM: 606944) erbin isoform 2 [Homo sapiens (1371 aa)
initn: 171 init1: 83 opt: 198 Z-score: 183.8 bits: 43.0 E(85289): 0.0017
Smith-Waterman score: 198; 38.9% identity (63.9% similar) in 108 aa overlap (5-112:1270-1368)
10 20 30
pF1KE2 MSYIPGQPVTAVVQRVEIHKLRQGENLILGFSIG
: : . :..... .. : :::::.
NP_061 VARHPSREQLIDYLMLKVAHQPPYTQPHCSPRQGHELAKQEIRVRVEKDPE---LGFSIS
1240 1250 1260 1270 1280 1290
40 50 60 70 80 90
pF1KE2 GGIDQDPSQNPFSEDKTDKGIYVTRVSEGGPAEIAGLQIGDKIMQVNGWDMTMVTHDQAR
::. ::: : : ::.::::. ::: :: ::::.:.::... . : ::
NP_061 GGVG--GRGNPFRPD--DDGIFVTRVQPEGPASKL-LQPGDKIIQANGYSFINIEHGQAV
1300 1310 1320 1330 1340 1350
100 110 120
pF1KE2 KRLTKRSEEVVRLLVTRQSLQKAVQQSMLS
. : : ...:.:...:.
NP_061 S-LLKTFQNTVELIIVREVSS
1360 1370
>>NP_001240626 (OMIM: 606944) erbin isoform 1 [Homo sapi (1412 aa)
initn: 171 init1: 83 opt: 198 Z-score: 183.6 bits: 43.0 E(85289): 0.0017
Smith-Waterman score: 198; 38.9% identity (63.9% similar) in 108 aa overlap (5-112:1311-1409)
10 20 30
pF1KE2 MSYIPGQPVTAVVQRVEIHKLRQGENLILGFSIG
: : . :..... .. : :::::.
NP_001 VARHPSREQLIDYLMLKVAHQPPYTQPHCSPRQGHELAKQEIRVRVEKDPE---LGFSIS
1290 1300 1310 1320 1330
40 50 60 70 80 90
pF1KE2 GGIDQDPSQNPFSEDKTDKGIYVTRVSEGGPAEIAGLQIGDKIMQVNGWDMTMVTHDQAR
::. ::: : : ::.::::. ::: :: ::::.:.::... . : ::
NP_001 GGVG--GRGNPFRPD--DDGIFVTRVQPEGPASKL-LQPGDKIIQANGYSFINIEHGQAV
1340 1350 1360 1370 1380 1390
100 110 120
pF1KE2 KRLTKRSEEVVRLLVTRQSLQKAVQQSMLS
. : : ...:.:...:.
NP_001 S-LLKTFQNTVELIIVREVSS
1400 1410
>>XP_016865125 (OMIM: 606944) PREDICTED: protein LAP2 is (1415 aa)
initn: 171 init1: 83 opt: 198 Z-score: 183.6 bits: 43.0 E(85289): 0.0017
Smith-Waterman score: 198; 38.9% identity (63.9% similar) in 108 aa overlap (5-112:1314-1412)
10 20 30
pF1KE2 MSYIPGQPVTAVVQRVEIHKLRQGENLILGFSIG
: : . :..... .. : :::::.
XP_016 VARHPSREQLIDYLMLKVAHQPPYTQPHCSPRQGHELAKQEIRVRVEKDPE---LGFSIS
1290 1300 1310 1320 1330 1340
40 50 60 70 80 90
pF1KE2 GGIDQDPSQNPFSEDKTDKGIYVTRVSEGGPAEIAGLQIGDKIMQVNGWDMTMVTHDQAR
::. ::: : : ::.::::. ::: :: ::::.:.::... . : ::
XP_016 GGVG--GRGNPFRPD--DDGIFVTRVQPEGPASKL-LQPGDKIIQANGYSFINIEHGQAV
1350 1360 1370 1380 1390
100 110 120
pF1KE2 KRLTKRSEEVVRLLVTRQSLQKAVQQSMLS
. : : ...:.:...:.
XP_016 S-LLKTFQNTVELIIVREVSS
1400 1410
>>NP_001240628 (OMIM: 606944) erbin isoform 8 [Homo sapi (1419 aa)
initn: 171 init1: 83 opt: 198 Z-score: 183.6 bits: 43.0 E(85289): 0.0017
Smith-Waterman score: 198; 38.9% identity (63.9% similar) in 108 aa overlap (5-112:1318-1416)
10 20 30
pF1KE2 MSYIPGQPVTAVVQRVEIHKLRQGENLILGFSIG
: : . :..... .. : :::::.
NP_001 VARHPSREQLIDYLMLKVAHQPPYTQPHCSPRQGHELAKQEIRVRVEKDPE---LGFSIS
1290 1300 1310 1320 1330 1340
40 50 60 70 80 90
pF1KE2 GGIDQDPSQNPFSEDKTDKGIYVTRVSEGGPAEIAGLQIGDKIMQVNGWDMTMVTHDQAR
::. ::: : : ::.::::. ::: :: ::::.:.::... . : ::
NP_001 GGVG--GRGNPFRPD--DDGIFVTRVQPEGPASKL-LQPGDKIIQANGYSFINIEHGQAV
1350 1360 1370 1380 1390
100 110 120
pF1KE2 KRLTKRSEEVVRLLVTRQSLQKAVQQSMLS
. : : ...:.:...:.
NP_001 S-LLKTFQNTVELIIVREVSS
1400 1410
124 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 14:00:49 2016 done: Sun Nov 6 14:00:50 2016
Total Scan time: 4.910 Total Display time: -0.020
Function used was FASTA [36.3.4 Apr, 2011]