FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE5631, 477 aa 1>>>pF1KE5631 477 - 477 aa - 477 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.1950+/-0.000349; mu= 18.8114+/- 0.022 mean_var=68.7726+/-14.077, 0's: 0 Z-trim(115.0): 28 B-trim: 977 in 2/57 Lambda= 0.154656 statistics sampled from 25090 (25117) to 25090 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.659), E-opt: 0.2 (0.294), width: 16 Scan time: 6.880 The best scores are: opt bits E(85289) NP_892026 (OMIM: 607975) oxidative stress-induced ( 477) 3232 730.2 3e-210 XP_011515590 (OMIM: 604598) PREDICTED: oxidative s ( 372) 824 192.8 1.4e-48 XP_011515589 (OMIM: 604598) PREDICTED: oxidative s ( 505) 782 183.5 1.2e-45 NP_004328 (OMIM: 604598) oxidative stress-induced ( 505) 782 183.5 1.2e-45 NP_001119583 (OMIM: 604598) oxidative stress-induc ( 549) 782 183.6 1.2e-45 >>NP_892026 (OMIM: 607975) oxidative stress-induced grow (477 aa) initn: 3232 init1: 3232 opt: 3232 Z-score: 3895.5 bits: 730.2 E(85289): 3e-210 Smith-Waterman score: 3232; 100.0% identity (100.0% similar) in 477 aa overlap (1-477:1-477) 10 20 30 40 50 60 pF1KE5 MSSSRKDHLGASSSEPLPVIIVGNGPSGICLSYLLSGYTPYTKPDAIHPHPLLQRKLTEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_892 MSSSRKDHLGASSSEPLPVIIVGNGPSGICLSYLLSGYTPYTKPDAIHPHPLLQRKLTEA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 PGVSILDQDLDYLSEGLEGRSQSPVALLFDALLRPDTDFGGNMKSVLTWKHRKEHAIPHV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_892 PGVSILDQDLDYLSEGLEGRSQSPVALLFDALLRPDTDFGGNMKSVLTWKHRKEHAIPHV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE5 VLGRNLPGGAWHSIEGSMVILSQGQWMGLPDLEVKDWMQKKRRGLRNSRATAGDIAHYYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_892 VLGRNLPGGAWHSIEGSMVILSQGQWMGLPDLEVKDWMQKKRRGLRNSRATAGDIAHYYR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE5 DYVVKKGLGHNFVSGAVVTAVEWGTPDPSSCGAQDSSPLFQVSGFLTRNQAQQPFSLWAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_892 DYVVKKGLGHNFVSGAVVTAVEWGTPDPSSCGAQDSSPLFQVSGFLTRNQAQQPFSLWAR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE5 NVVLATGTFDSPARLGIPGEALPFIHHELSALEAATRVGAVTPASDPVLIIGAGLSAADA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_892 NVVLATGTFDSPARLGIPGEALPFIHHELSALEAATRVGAVTPASDPVLIIGAGLSAADA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE5 VLYARHYNIPVIHAFRRAVDDPGLVFNQLPKMLYPEYHKVHQMMREQSILSPSPYEGYRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_892 VLYARHYNIPVIHAFRRAVDDPGLVFNQLPKMLYPEYHKVHQMMREQSILSPSPYEGYRS 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE5 LPRHQLLCFKEDCQAVFQDLEGVEKVFGVSLVLVLIGSHPDLSFLPGAGADFAVDPDQPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_892 LPRHQLLCFKEDCQAVFQDLEGVEKVFGVSLVLVLIGSHPDLSFLPGAGADFAVDPDQPL 370 380 390 400 410 420 430 440 450 460 470 pF1KE5 SAKRNPIDVDPFTYQSTRQEGLYAMGPLAGDNFVRFVQGGALAVASSLLRKETRKPP ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_892 SAKRNPIDVDPFTYQSTRQEGLYAMGPLAGDNFVRFVQGGALAVASSLLRKETRKPP 430 440 450 460 470 >>XP_011515590 (OMIM: 604598) PREDICTED: oxidative stres (372 aa) initn: 987 init1: 455 opt: 824 Z-score: 993.4 bits: 192.8 E(85289): 1.4e-48 Smith-Waterman score: 1014; 45.7% identity (70.2% similar) in 359 aa overlap (134-475:1-359) 110 120 130 140 150 160 pF1KE5 KSVLTWKHRKEHAIPHVVLGRNLPGGAWHSIEGSMVILSQGQWMGLPDLEVKDWMQKKRR .::::. .: :.:: :: :. :::...::: XP_011 MEGSMLTISFGSWMELPGLKFKDWVSSKRR 10 20 30 170 180 190 200 210 220 pF1KE5 GLRNSRATAGDIAHYYRDYVVKKGLGHNFVSGAVVTAVEWGTPDPSSCGAQD---SSPLF .:...:. .::.::. :: :: .:: .. .:.: : .. :: :. . XP_011 SLKGDRVMPEEIARYYKHYVKVMGLQKNFRENTYITSVSRLYRDQDDDDIQDRDISTKHL 40 50 60 70 80 90 230 240 250 260 pF1KE5 QV--SGFLTRNQ-----------AQQPFSLWARNVVLATGTFDSPARLGIPGEALPFIHH :. :.:. :: .. :: :.:.::.:::::.::::.: : :: .::. : XP_011 QIEKSNFIKRNWEIRGYQRIADGSHVPFCLFAENVALATGTLDSPAHLEIEGEDFPFVFH 100 110 120 130 140 150 270 280 290 300 310 320 pF1KE5 ELSALEAATRVGAVTPASDPVLIIGAGLSAADAVLYARHYNIPVIHAFRRAVDDPGLVFN . . :: : . :::::.:.::.:::::: : . ::::::.::: : ::.:.:. XP_011 SMPEFGAAINKGKLRGKVDPVLIVGSGLTAADAVLCAYNSNIPVIHVFRRRVTDPSLIFK 160 170 180 190 200 210 330 340 350 360 370 380 pF1KE5 QLPKMLYPEYHKVHQMMREQSILSPSPY-EGYRSLPRHQLLCFKEDCQAVFQDLEGVEKV :::: ::::::::..:: :: : : :.:.:..: :: : . :.:.. :..:. XP_011 QLPKKLYPEYHKVYHMMCTQSYSVDSNLLSDYTSFPEHRVLSFKSDMKCVLQSVSGLKKI 220 230 240 250 260 270 390 400 410 420 430 440 pF1KE5 FGVSLVLVLIGSHPDLSFLPGAGADFAVDPDQPLSAKRNPIDVDPFTYQSTRQEGLYAMG : .: ..:::::::.:::: : .. .::.. : ::...: .::. .. .:.:.: XP_011 FKLSAAVVLIGSHPNLSFLKDQGCYLGHKSSQPITCKGNPVEIDTYTYECIKEANLFALG 280 290 300 310 320 330 450 460 470 pF1KE5 PLAGDNFVRFVQGGALAVASSLLRKETRKPP ::.:::::::..::::.:. : .. .: XP_011 PLVGDNFVRFLKGGALGVTRCLATRQKKKHLFVERGGGDGIA 340 350 360 370 >>XP_011515589 (OMIM: 604598) PREDICTED: oxidative stres (505 aa) initn: 1545 init1: 769 opt: 782 Z-score: 940.8 bits: 183.5 E(85289): 1.2e-45 Smith-Waterman score: 1572; 50.6% identity (74.4% similar) in 480 aa overlap (13-475:13-492) 10 20 30 40 50 60 pF1KE5 MSSSRKDHLGASSSEPLPVIIVGNGPSGICLSYLLSGYTPYTKPDAIHPHPLLQRKLTEA :: .::.:.:::::::::::.:::: :: . .::::. .:. :: :: XP_011 MPLVEETSLLEDSSVTFPVVIIGNGPSGICLSYMLSGYRPYLSSEAIHPNTILNSKLEEA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 PGVSILDQDLDYLSEGLEGRSQSPVALLFDALLRPDTDFGGNMKSVLTWKHRKEHAIPHV .::.::::.::::::::::..:::.:::.::.::.::: .. ::: :: ...: :::: XP_011 RHLSIVDQDLEYLSEGLEGRSSNPVAVLFDTLLHPDADFGYDYPSVLHWKLEQHHYIPHV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE5 VLGRNLPGGAWHSIEGSMVILSQGQWMGLPDLEVKDWMQKKRRGLRNSRATAGDIAHYYR :::.. ::::::..::::. .: :.:: :: :. :::...:::.:...:. .::.::. XP_011 VLGKGPPGGAWHNMEGSMLTISFGSWMELPGLKFKDWVSSKRRSLKGDRVMPEEIARYYK 130 140 150 160 170 180 190 200 210 220 230 pF1KE5 DYVVKKGLGHNFVSGAVVTAVEWGTPDPSSCGAQD---SSPLFQV--SGFLTRNQ----- :: :: .:: .. .:.: : .. :: :. .:. :.:. :: XP_011 HYVKVMGLQKNFRENTYITSVSRLYRDQDDDDIQDRDISTKHLQIEKSNFIKRNWEIRGY 190 200 210 220 230 240 240 250 260 270 280 pF1KE5 ------AQQPFSLWARNVVLATGTFDSPARLGIPGEALPFIHHELSALEAATRVGAVTPA .. :: :.:.::.:::::.::::.: : :: .::. : . . :: : . XP_011 QRIADGSHVPFCLFAENVALATGTLDSPAHLEIEGEDFPFVFHSMPEFGAAINKGKLRGK 250 260 270 280 290 300 290 300 310 320 330 340 pF1KE5 SDPVLIIGAGLSAADAVLYARHYNIPVIHAFRRAVDDPGLVFNQLPKMLYPEYHKVHQMM :::::.:.::.:::::: : . ::::::.::: : ::.:.:.:::: ::::::::..:: XP_011 VDPVLIVGSGLTAADAVLCAYNSNIPVIHVFRRRVTDPSLIFKQLPKKLYPEYHKVYHMM 310 320 330 340 350 360 350 360 370 380 390 400 pF1KE5 REQSILSPSPY-EGYRSLPRHQLLCFKEDCQAVFQDLEGVEKVFGVSLVLVLIGSHPDLS :: : : :.:.:..: :: : . :.:.. :..:.: .: ..:::::::.:: XP_011 CTQSYSVDSNLLSDYTSFPEHRVLSFKSDMKCVLQSVSGLKKIFKLSAAVVLIGSHPNLS 370 380 390 400 410 420 410 420 430 440 450 460 pF1KE5 FLPGAGADFAVDPDQPLSAKRNPIDVDPFTYQSTRQEGLYAMGPLAGDNFVRFVQGGALA :: : .. .::.. : ::...: .::. .. .:.:.:::.:::::::..::::. XP_011 FLKDQGCYLGHKSSQPITCKGNPVEIDTYTYECIKEANLFALGPLVGDNFVRFLKGGALG 430 440 450 460 470 480 470 pF1KE5 VASSLLRKETRKPP :. : .. .: XP_011 VTRCLATRQKKKHLFVERGGGDGIA 490 500 >>NP_004328 (OMIM: 604598) oxidative stress-induced grow (505 aa) initn: 1545 init1: 769 opt: 782 Z-score: 940.8 bits: 183.5 E(85289): 1.2e-45 Smith-Waterman score: 1572; 50.6% identity (74.4% similar) in 480 aa overlap (13-475:13-492) 10 20 30 40 50 60 pF1KE5 MSSSRKDHLGASSSEPLPVIIVGNGPSGICLSYLLSGYTPYTKPDAIHPHPLLQRKLTEA :: .::.:.:::::::::::.:::: :: . .::::. .:. :: :: NP_004 MPLVEETSLLEDSSVTFPVVIIGNGPSGICLSYMLSGYRPYLSSEAIHPNTILNSKLEEA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 PGVSILDQDLDYLSEGLEGRSQSPVALLFDALLRPDTDFGGNMKSVLTWKHRKEHAIPHV .::.::::.::::::::::..:::.:::.::.::.::: .. ::: :: ...: :::: NP_004 RHLSIVDQDLEYLSEGLEGRSSNPVAVLFDTLLHPDADFGYDYPSVLHWKLEQHHYIPHV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE5 VLGRNLPGGAWHSIEGSMVILSQGQWMGLPDLEVKDWMQKKRRGLRNSRATAGDIAHYYR :::.. ::::::..::::. .: :.:: :: :. :::...:::.:...:. .::.::. NP_004 VLGKGPPGGAWHNMEGSMLTISFGSWMELPGLKFKDWVSSKRRSLKGDRVMPEEIARYYK 130 140 150 160 170 180 190 200 210 220 230 pF1KE5 DYVVKKGLGHNFVSGAVVTAVEWGTPDPSSCGAQD---SSPLFQV--SGFLTRNQ----- :: :: .:: .. .:.: : .. :: :. .:. :.:. :: NP_004 HYVKVMGLQKNFRENTYITSVSRLYRDQDDDDIQDRDISTKHLQIEKSNFIKRNWEIRGY 190 200 210 220 230 240 240 250 260 270 280 pF1KE5 ------AQQPFSLWARNVVLATGTFDSPARLGIPGEALPFIHHELSALEAATRVGAVTPA .. :: :.:.::.:::::.::::.: : :: .::. : . . :: : . NP_004 QRIADGSHVPFCLFAENVALATGTLDSPAHLEIEGEDFPFVFHSMPEFGAAINKGKLRGK 250 260 270 280 290 300 290 300 310 320 330 340 pF1KE5 SDPVLIIGAGLSAADAVLYARHYNIPVIHAFRRAVDDPGLVFNQLPKMLYPEYHKVHQMM :::::.:.::.:::::: : . ::::::.::: : ::.:.:.:::: ::::::::..:: NP_004 VDPVLIVGSGLTAADAVLCAYNSNIPVIHVFRRRVTDPSLIFKQLPKKLYPEYHKVYHMM 310 320 330 340 350 360 350 360 370 380 390 400 pF1KE5 REQSILSPSPY-EGYRSLPRHQLLCFKEDCQAVFQDLEGVEKVFGVSLVLVLIGSHPDLS :: : : :.:.:..: :: : . :.:.. :..:.: .: ..:::::::.:: NP_004 CTQSYSVDSNLLSDYTSFPEHRVLSFKSDMKCVLQSVSGLKKIFKLSAAVVLIGSHPNLS 370 380 390 400 410 420 410 420 430 440 450 460 pF1KE5 FLPGAGADFAVDPDQPLSAKRNPIDVDPFTYQSTRQEGLYAMGPLAGDNFVRFVQGGALA :: : .. .::.. : ::...: .::. .. .:.:.:::.:::::::..::::. NP_004 FLKDQGCYLGHKSSQPITCKGNPVEIDTYTYECIKEANLFALGPLVGDNFVRFLKGGALG 430 440 450 460 470 480 470 pF1KE5 VASSLLRKETRKPP :. : .. .: NP_004 VTRCLATRQKKKHLFVERGGGDGIA 490 500 >>NP_001119583 (OMIM: 604598) oxidative stress-induced g (549 aa) initn: 1545 init1: 769 opt: 782 Z-score: 940.3 bits: 183.6 E(85289): 1.2e-45 Smith-Waterman score: 1572; 50.6% identity (74.4% similar) in 480 aa overlap (13-475:57-536) 10 20 30 40 pF1KE5 MSSSRKDHLGASSSEPLPVIIVGNGPSGICLSYLLSGYTPYT :: .::.:.:::::::::::.:::: :: NP_001 FNSLVQYFGDNLGRKVKAMPLVEETSLLEDSSVTFPVVIIGNGPSGICLSYMLSGYRPYL 30 40 50 60 70 80 50 60 70 80 90 100 pF1KE5 KPDAIHPHPLLQRKLTEAPGVSILDQDLDYLSEGLEGRSQSPVALLFDALLRPDTDFGGN . .::::. .:. :: :: .::.::::.::::::::::..:::.:::.::.::.::: . NP_001 SSEAIHPNTILNSKLEEARHLSIVDQDLEYLSEGLEGRSSNPVAVLFDTLLHPDADFGYD 90 100 110 120 130 140 110 120 130 140 150 160 pF1KE5 MKSVLTWKHRKEHAIPHVVLGRNLPGGAWHSIEGSMVILSQGQWMGLPDLEVKDWMQKKR . ::: :: ...: :::::::.. ::::::..::::. .: :.:: :: :. :::...:: NP_001 YPSVLHWKLEQHHYIPHVVLGKGPPGGAWHNMEGSMLTISFGSWMELPGLKFKDWVSSKR 150 160 170 180 190 200 170 180 190 200 210 pF1KE5 RGLRNSRATAGDIAHYYRDYVVKKGLGHNFVSGAVVTAVEWGTPDPSSCGAQD---SSPL :.:...:. .::.::. :: :: .:: .. .:.: : .. :: :. NP_001 RSLKGDRVMPEEIARYYKHYVKVMGLQKNFRENTYITSVSRLYRDQDDDDIQDRDISTKH 210 220 230 240 250 260 220 230 240 250 260 pF1KE5 FQV--SGFLTRNQ-----------AQQPFSLWARNVVLATGTFDSPARLGIPGEALPFIH .:. :.:. :: .. :: :.:.::.:::::.::::.: : :: .::. NP_001 LQIEKSNFIKRNWEIRGYQRIADGSHVPFCLFAENVALATGTLDSPAHLEIEGEDFPFVF 270 280 290 300 310 320 270 280 290 300 310 320 pF1KE5 HELSALEAATRVGAVTPASDPVLIIGAGLSAADAVLYARHYNIPVIHAFRRAVDDPGLVF : . . :: : . :::::.:.::.:::::: : . ::::::.::: : ::.:.: NP_001 HSMPEFGAAINKGKLRGKVDPVLIVGSGLTAADAVLCAYNSNIPVIHVFRRRVTDPSLIF 330 340 350 360 370 380 330 340 350 360 370 380 pF1KE5 NQLPKMLYPEYHKVHQMMREQSILSPSPY-EGYRSLPRHQLLCFKEDCQAVFQDLEGVEK .:::: ::::::::..:: :: : : :.:.:..: :: : . :.:.. :..: NP_001 KQLPKKLYPEYHKVYHMMCTQSYSVDSNLLSDYTSFPEHRVLSFKSDMKCVLQSVSGLKK 390 400 410 420 430 440 390 400 410 420 430 440 pF1KE5 VFGVSLVLVLIGSHPDLSFLPGAGADFAVDPDQPLSAKRNPIDVDPFTYQSTRQEGLYAM .: .: ..:::::::.:::: : .. .::.. : ::...: .::. .. .:.:. NP_001 IFKLSAAVVLIGSHPNLSFLKDQGCYLGHKSSQPITCKGNPVEIDTYTYECIKEANLFAL 450 460 470 480 490 500 450 460 470 pF1KE5 GPLAGDNFVRFVQGGALAVASSLLRKETRKPP :::.:::::::..::::.:. : .. .: NP_001 GPLVGDNFVRFLKGGALGVTRCLATRQKKKHLFVERGGGDGIA 510 520 530 540 477 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 05:21:24 2016 done: Tue Nov 8 05:21:25 2016 Total Scan time: 6.880 Total Display time: 0.030 Function used was FASTA [36.3.4 Apr, 2011]