FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB9813, 272 aa 1>>>pF1KB9813 272 - 272 aa - 272 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.1227+/-0.000286; mu= 13.0199+/- 0.018 mean_var=113.1788+/-22.768, 0's: 0 Z-trim(121.1): 24 B-trim: 33 in 1/56 Lambda= 0.120557 statistics sampled from 37255 (37280) to 37255 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.771), E-opt: 0.2 (0.437), width: 16 Scan time: 8.460 The best scores are: opt bits E(85289) NP_478126 (OMIM: 606490) exosome complex component ( 272) 1805 323.9 2e-88 NP_061910 (OMIM: 606491) exosome complex component ( 245) 274 57.6 2.6e-08 XP_011515436 (OMIM: 606491) PREDICTED: exosome com ( 147) 202 44.9 0.00011 NP_064543 (OMIM: 606492) exosome complex component ( 235) 188 42.6 0.00081 >>NP_478126 (OMIM: 606490) exosome complex component MTR (272 aa) initn: 1805 init1: 1805 opt: 1805 Z-score: 1708.6 bits: 323.9 E(85289): 2e-88 Smith-Waterman score: 1805; 100.0% identity (100.0% similar) in 272 aa overlap (1-272:1-272) 10 20 30 40 50 60 pF1KB9 MPGDHRRIRGPEESQPPQLYAADEEEAPGTRDPTRLRPVYARAGLLSQAKGSAYLEAGGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_478 MPGDHRRIRGPEESQPPQLYAADEEEAPGTRDPTRLRPVYARAGLLSQAKGSAYLEAGGT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 KVLCAVSGPRQAEGGERGGGPAGAGGEAPAALRGRLLCDFRRAPFAGRRRRAPPGGCEER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_478 KVLCAVSGPRQAEGGERGGGPAGAGGEAPAALRGRLLCDFRRAPFAGRRRRAPPGGCEER 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 ELALALQEALEPAVRLGRYPRAQLEVSALLLEDGGSALAAALTAAALALADAGVEMYDLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_478 ELALALQEALEPAVRLGRYPRAQLEVSALLLEDGGSALAAALTAAALALADAGVEMYDLV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB9 VGCGLSLAPGPAPTWLLDPTRLEEERAAAGLTVALMPVLNQVAGLLGSGEGGLTESWAEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_478 VGCGLSLAPGPAPTWLLDPTRLEEERAAAGLTVALMPVLNQVAGLLGSGEGGLTESWAEA 190 200 210 220 230 240 250 260 270 pF1KB9 VRLGLEGCQRLYPVLQQSLVRAARRRGAAAQP :::::::::::::::::::::::::::::::: NP_478 VRLGLEGCQRLYPVLQQSLVRAARRRGAAAQP 250 260 270 >>NP_061910 (OMIM: 606491) exosome complex component RRP (245 aa) initn: 256 init1: 136 opt: 274 Z-score: 270.1 bits: 57.6 E(85289): 2.6e-08 Smith-Waterman score: 359; 34.2% identity (65.8% similar) in 196 aa overlap (31-225:17-199) 10 20 30 40 50 60 pF1KB9 MPGDHRRIRGPEESQPPQLYAADEEEAPGTRDPTRLRPVYARAGLLSQAKGSAYLEAGGT : .:: . :: :...:: ::::.: :.: NP_061 MAGLELLSDQGYRVDGRRAGELRKIQARMGVFAQADGSAYIEQGNT 10 20 30 40 70 80 90 100 110 pF1KB9 KVLCAVSGPRQAEGGERGGGPAGAGGEAPAALRGRLLCDFRRAPFA-GRRRRAPPGGCEE :.: .: ::.. .:.. . : :. . :.. : :. :.:.: : : . NP_061 KALAVVYGPHEIRGSRARALPD----------RALVNCQYSSATFSTGERKRRPHGDRKS 50 60 70 80 90 120 130 140 150 160 170 pF1KB9 RELALALQEALEPAVRLGRYPRAQLEVSALLLEDGGSALAAALTAAALALADAGVEMYDL :..: :....: :. .::.:... . .:. :.. :: ..::.::. :::. : :. NP_061 CEMGLQLRQTFEAAILTQLHPRSQIDIYVQVLQADGGTYAACVNAATLAVLDAGIPMRDF 100 110 120 130 140 150 180 190 200 210 220 230 pF1KB9 VVGCGLSLAPGPAPTWLLDPTRLEEERAAAGLTVALMPVLNQVAGLLGSGEGGLTESWAE : .:. ... : : : : ...:: .. :..::.:. .:.: : NP_061 VCACSAGFVDGTA---LADLSHVEEAAGGPQLALALLPASGQIALLEMDARLHEDHLERV 160 170 180 190 200 210 240 250 260 270 pF1KB9 AVRLGLEGCQRLYPVLQQSLVRAARRRGAAAQP NP_061 LEAAAQAARDVHTLLDRVVRQHVREASILLGD 220 230 240 >>XP_011515436 (OMIM: 606491) PREDICTED: exosome complex (147 aa) initn: 152 init1: 136 opt: 202 Z-score: 205.4 bits: 44.9 E(85289): 0.00011 Smith-Waterman score: 202; 33.7% identity (71.2% similar) in 104 aa overlap (122-225:1-101) 100 110 120 130 140 150 pF1KB9 LRGRLLCDFRRAPFAGRRRRAPPGGCEERELALALQEALEPAVRLGRYPRAQLEVSALLL ..: :....: :. .::.:... . .: XP_011 MGLQLRQTFEAAILTQLHPRSQIDIYVQVL 10 20 30 160 170 180 190 200 210 pF1KB9 EDGGSALAAALTAAALALADAGVEMYDLVVGCGLSLAPGPAPTWLLDPTRLEEERAAAGL . :.. :: ..::.::. :::. : :.: .:. ... : : : : ...:: .. : XP_011 QADGGTYAACVNAATLAVLDAGIPMRDFVCACSAGFVDGTA---LADLSHVEEAAGGPQL 40 50 60 70 80 220 230 240 250 260 270 pF1KB9 TVALMPVLNQVAGLLGSGEGGLTESWAEAVRLGLEGCQRLYPVLQQSLVRAARRRGAAAQ ..::.:. .:.: : XP_011 ALALLPASGQIALLEMDARLHEDHLERVLEAAAQAARDVHTLLDRVVRQHVREASILLGD 90 100 110 120 130 140 >>NP_064543 (OMIM: 606492) exosome complex component RRP (235 aa) initn: 182 init1: 121 opt: 188 Z-score: 189.5 bits: 42.6 E(85289): 0.00081 Smith-Waterman score: 213; 30.0% identity (53.4% similar) in 253 aa overlap (12-261:3-230) 10 20 30 40 50 pF1KB9 MPGDHRRIRGPEESQPPQLYAADEEEAPGTRDP-TRLRPVYARAGLLSQAKGSAYLEAGG ::.. :.. . . : : :: . .:::. ::: . : NP_064 MEEETHTDAKIRAENGTGSSPRGPGCSLRHFACEQNLLSRPDGSASFLQGD 10 20 30 40 50 60 70 80 90 100 110 pF1KB9 TKVLCAVSGPRQAEGGERGGGPAGAGGEAPAALRGRLLCDFRRAPFAGRRRRAPPGGCEE :.:: .: :: ... ... . : . :: : : :: :. NP_064 TSVLAGVYGPAEVKVSKEIFNKA----TLEVILR----------PKIGL-----PGVAEK 60 70 80 90 120 130 140 150 160 170 pF1KB9 RELALALQEALEPAVRLGR-YPRAQLEVSALLLEDGGSALAAALTAAALALADAGVEMYD . : .... : :: :: .::... : .. :.:: :: :.:: .::.:::: : NP_064 SRERL-IRNTCE-AVVLGTLHPRTSITVVLQVVSDAGSLLACCLNAACMALVDAGVPMRA 100 110 120 130 140 150 180 190 200 210 220 230 pF1KB9 LVVGCGLSLAPGPAPTWLLDPTRLEEERAAAGLTVALMPVLNQVAGLLGSGEGGLTES-W : ::.. : : .:::: .:..: : :: :: : .. :..: .: ... NP_064 LF--CGVACALDSDGTLVLDPTSKQEKEARAVLTFALDSVERKL--LMSSTKGLYSDTEL 160 170 180 190 200 240 250 260 270 pF1KB9 AEAVRLGLEGCQRLYPVLQQSLVRAARRRGAAAQP . . . . :... ..:: : NP_064 QQCLAAAQAASQHVFRFYRESLQRRYSKS 210 220 230 272 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 07:38:49 2016 done: Tue Nov 8 07:38:50 2016 Total Scan time: 8.460 Total Display time: -0.020 Function used was FASTA [36.3.4 Apr, 2011]