FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE2535, 281 aa 1>>>pF1KE2535 281 - 281 aa - 281 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.8795+/-0.000344; mu= 17.4946+/- 0.021 mean_var=62.7955+/-12.638, 0's: 0 Z-trim(113.4): 22 B-trim: 0 in 0/50 Lambda= 0.161849 statistics sampled from 22725 (22745) to 22725 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.658), E-opt: 0.2 (0.267), width: 16 Scan time: 5.860 The best scores are: opt bits E(85289) NP_619515 (OMIM: 602428) hyaluronan synthase 3 iso ( 281) 1873 445.8 4.1e-125 XP_005255978 (OMIM: 602428) PREDICTED: hyaluronan ( 553) 1634 390.2 4.4e-108 NP_005320 (OMIM: 602428) hyaluronan synthase 3 iso ( 553) 1634 390.2 4.4e-108 XP_011521363 (OMIM: 602428) PREDICTED: hyaluronan ( 553) 1634 390.2 4.4e-108 NP_001186209 (OMIM: 602428) hyaluronan synthase 3 ( 553) 1634 390.2 4.4e-108 NP_005319 (OMIM: 601636) hyaluronan synthase 2 [Ho ( 552) 1041 251.8 2.1e-66 XP_011525186 (OMIM: 601463) PREDICTED: hyaluronan ( 328) 361 92.8 8.9e-19 NP_001284365 (OMIM: 601463) hyaluronan synthase 1 ( 577) 361 93.0 1.4e-18 NP_001514 (OMIM: 601463) hyaluronan synthase 1 iso ( 578) 361 93.0 1.4e-18 >>NP_619515 (OMIM: 602428) hyaluronan synthase 3 isoform (281 aa) initn: 1873 init1: 1873 opt: 1873 Z-score: 2367.1 bits: 445.8 E(85289): 4.1e-125 Smith-Waterman score: 1873; 100.0% identity (100.0% similar) in 281 aa overlap (1-281:1-281) 10 20 30 40 50 60 pF1KE2 MPVQLTTALRVVGTSLFALAVLGGILAAYVTGYQFIHTEKHYLSFGLYGAILGLHLLIQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_619 MPVQLTTALRVVGTSLFALAVLGGILAAYVTGYQFIHTEKHYLSFGLYGAILGLHLLIQS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 LFAFLEHRRMRRAGQALKLPSPRRGSVALCIAAYQEDPDYLRKCLRSAQRISFPDLKVVM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_619 LFAFLEHRRMRRAGQALKLPSPRRGSVALCIAAYQEDPDYLRKCLRSAQRISFPDLKVVM 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 VVDGNRQEDAYMLDIFHEVLGGTEQAGFFVWRSNFHEAGEGETEASLQEGMDRVRDVVRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_619 VVDGNRQEDAYMLDIFHEVLGGTEQAGFFVWRSNFHEAGEGETEASLQEGMDRVRDVVRA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 STFSCIMQKWGGKREVMYTAFKALGDSVDYIQVCDSDTVLDPACTIEMLRVLEEDPQVGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_619 STFSCIMQKWGGKREVMYTAFKALGDSVDYIQVCDSDTVLDPACTIEMLRVLEEDPQVGG 190 200 210 220 230 240 250 260 270 280 pF1KE2 VGGDVQPPGKGMAVEDDQVQAAQVRATEAWSVHQRHVSREQ ::::::::::::::::::::::::::::::::::::::::: NP_619 VGGDVQPPGKGMAVEDDQVQAAQVRATEAWSVHQRHVSREQ 250 260 270 280 >>XP_005255978 (OMIM: 602428) PREDICTED: hyaluronan synt (553 aa) initn: 1634 init1: 1634 opt: 1634 Z-score: 2061.3 bits: 390.2 E(85289): 4.4e-108 Smith-Waterman score: 1634; 100.0% identity (100.0% similar) in 246 aa overlap (1-246:1-246) 10 20 30 40 50 60 pF1KE2 MPVQLTTALRVVGTSLFALAVLGGILAAYVTGYQFIHTEKHYLSFGLYGAILGLHLLIQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MPVQLTTALRVVGTSLFALAVLGGILAAYVTGYQFIHTEKHYLSFGLYGAILGLHLLIQS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 LFAFLEHRRMRRAGQALKLPSPRRGSVALCIAAYQEDPDYLRKCLRSAQRISFPDLKVVM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LFAFLEHRRMRRAGQALKLPSPRRGSVALCIAAYQEDPDYLRKCLRSAQRISFPDLKVVM 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 VVDGNRQEDAYMLDIFHEVLGGTEQAGFFVWRSNFHEAGEGETEASLQEGMDRVRDVVRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VVDGNRQEDAYMLDIFHEVLGGTEQAGFFVWRSNFHEAGEGETEASLQEGMDRVRDVVRA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 STFSCIMQKWGGKREVMYTAFKALGDSVDYIQVCDSDTVLDPACTIEMLRVLEEDPQVGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 STFSCIMQKWGGKREVMYTAFKALGDSVDYIQVCDSDTVLDPACTIEMLRVLEEDPQVGG 190 200 210 220 230 240 250 260 270 280 pF1KE2 VGGDVQPPGKGMAVEDDQVQAAQVRATEAWSVHQRHVSREQ :::::: XP_005 VGGDVQILNKYDSWISFLSSVRYWMAFNVERACQSYFGCVQCISGPLGMYRNSLLQQFLE 250 260 270 280 290 300 >>NP_005320 (OMIM: 602428) hyaluronan synthase 3 isoform (553 aa) initn: 1634 init1: 1634 opt: 1634 Z-score: 2061.3 bits: 390.2 E(85289): 4.4e-108 Smith-Waterman score: 1634; 100.0% identity (100.0% similar) in 246 aa overlap (1-246:1-246) 10 20 30 40 50 60 pF1KE2 MPVQLTTALRVVGTSLFALAVLGGILAAYVTGYQFIHTEKHYLSFGLYGAILGLHLLIQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 MPVQLTTALRVVGTSLFALAVLGGILAAYVTGYQFIHTEKHYLSFGLYGAILGLHLLIQS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 LFAFLEHRRMRRAGQALKLPSPRRGSVALCIAAYQEDPDYLRKCLRSAQRISFPDLKVVM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 LFAFLEHRRMRRAGQALKLPSPRRGSVALCIAAYQEDPDYLRKCLRSAQRISFPDLKVVM 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 VVDGNRQEDAYMLDIFHEVLGGTEQAGFFVWRSNFHEAGEGETEASLQEGMDRVRDVVRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 VVDGNRQEDAYMLDIFHEVLGGTEQAGFFVWRSNFHEAGEGETEASLQEGMDRVRDVVRA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 STFSCIMQKWGGKREVMYTAFKALGDSVDYIQVCDSDTVLDPACTIEMLRVLEEDPQVGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 STFSCIMQKWGGKREVMYTAFKALGDSVDYIQVCDSDTVLDPACTIEMLRVLEEDPQVGG 190 200 210 220 230 240 250 260 270 280 pF1KE2 VGGDVQPPGKGMAVEDDQVQAAQVRATEAWSVHQRHVSREQ :::::: NP_005 VGGDVQILNKYDSWISFLSSVRYWMAFNVERACQSYFGCVQCISGPLGMYRNSLLQQFLE 250 260 270 280 290 300 >>XP_011521363 (OMIM: 602428) PREDICTED: hyaluronan synt (553 aa) initn: 1634 init1: 1634 opt: 1634 Z-score: 2061.3 bits: 390.2 E(85289): 4.4e-108 Smith-Waterman score: 1634; 100.0% identity (100.0% similar) in 246 aa overlap (1-246:1-246) 10 20 30 40 50 60 pF1KE2 MPVQLTTALRVVGTSLFALAVLGGILAAYVTGYQFIHTEKHYLSFGLYGAILGLHLLIQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MPVQLTTALRVVGTSLFALAVLGGILAAYVTGYQFIHTEKHYLSFGLYGAILGLHLLIQS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 LFAFLEHRRMRRAGQALKLPSPRRGSVALCIAAYQEDPDYLRKCLRSAQRISFPDLKVVM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LFAFLEHRRMRRAGQALKLPSPRRGSVALCIAAYQEDPDYLRKCLRSAQRISFPDLKVVM 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 VVDGNRQEDAYMLDIFHEVLGGTEQAGFFVWRSNFHEAGEGETEASLQEGMDRVRDVVRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VVDGNRQEDAYMLDIFHEVLGGTEQAGFFVWRSNFHEAGEGETEASLQEGMDRVRDVVRA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 STFSCIMQKWGGKREVMYTAFKALGDSVDYIQVCDSDTVLDPACTIEMLRVLEEDPQVGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 STFSCIMQKWGGKREVMYTAFKALGDSVDYIQVCDSDTVLDPACTIEMLRVLEEDPQVGG 190 200 210 220 230 240 250 260 270 280 pF1KE2 VGGDVQPPGKGMAVEDDQVQAAQVRATEAWSVHQRHVSREQ :::::: XP_011 VGGDVQILNKYDSWISFLSSVRYWMAFNVERACQSYFGCVQCISGPLGMYRNSLLQQFLE 250 260 270 280 290 300 >>NP_001186209 (OMIM: 602428) hyaluronan synthase 3 isof (553 aa) initn: 1634 init1: 1634 opt: 1634 Z-score: 2061.3 bits: 390.2 E(85289): 4.4e-108 Smith-Waterman score: 1634; 100.0% identity (100.0% similar) in 246 aa overlap (1-246:1-246) 10 20 30 40 50 60 pF1KE2 MPVQLTTALRVVGTSLFALAVLGGILAAYVTGYQFIHTEKHYLSFGLYGAILGLHLLIQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MPVQLTTALRVVGTSLFALAVLGGILAAYVTGYQFIHTEKHYLSFGLYGAILGLHLLIQS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 LFAFLEHRRMRRAGQALKLPSPRRGSVALCIAAYQEDPDYLRKCLRSAQRISFPDLKVVM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LFAFLEHRRMRRAGQALKLPSPRRGSVALCIAAYQEDPDYLRKCLRSAQRISFPDLKVVM 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 VVDGNRQEDAYMLDIFHEVLGGTEQAGFFVWRSNFHEAGEGETEASLQEGMDRVRDVVRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VVDGNRQEDAYMLDIFHEVLGGTEQAGFFVWRSNFHEAGEGETEASLQEGMDRVRDVVRA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 STFSCIMQKWGGKREVMYTAFKALGDSVDYIQVCDSDTVLDPACTIEMLRVLEEDPQVGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 STFSCIMQKWGGKREVMYTAFKALGDSVDYIQVCDSDTVLDPACTIEMLRVLEEDPQVGG 190 200 210 220 230 240 250 260 270 280 pF1KE2 VGGDVQPPGKGMAVEDDQVQAAQVRATEAWSVHQRHVSREQ :::::: NP_001 VGGDVQILNKYDSWISFLSSVRYWMAFNVERACQSYFGCVQCISGPLGMYRNSLLQQFLE 250 260 270 280 290 300 >>NP_005319 (OMIM: 601636) hyaluronan synthase 2 [Homo s (552 aa) initn: 764 init1: 483 opt: 1041 Z-score: 1313.0 bits: 251.8 E(85289): 2.1e-66 Smith-Waterman score: 1041; 61.8% identity (87.0% similar) in 238 aa overlap (9-246:10-243) 10 20 30 40 50 pF1KE2 MPVQLTTALRVVGTSLFALAVLGGILAAYVTGYQFIHTEKHYLSFGLYGAILGLHLLIQ ::..::.::....: :: :::..:::::.:...:.:::::::.:. ::.:: NP_005 MHCERFLCILRIIGTTLFGVSLLLGITAAYIVGYQFIQTDNYYFSFGLYGAFLASHLIIQ 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE2 SLFAFLEHRRMRRAGQALKLPSPRRGSVALCIAAYQEDPDYLRKCLRSAQRISFPDLKVV :::::::::.:... :. : .:::::::::::::::::::.:..:...: .::: NP_005 SLFAFLEHRKMKKS---LETPIKLNKTVALCIAAYQEDPDYLRKCLQSVKRLTYPGIKVV 70 80 90 100 110 120 130 140 150 160 170 pF1KE2 MVVDGNRQEDAYMLDIFHEVLGGTEQAGFFVWRSNFHEAGEGETEASLQEGMDRVRDVVR ::.::: ..: ::.::: ::.: .... ..:..:::: : :::. : .:. ..: ..: NP_005 MVIDGNSEDDLYMMDIFSEVMG-RDKSATYIWKNNFHEKGPGETDESHKESSQHVTQLVL 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE2 ASTFSCIMQKWGGKREVMYTAFKALGDSVDYIQVCDSDTVLDPACTIEMLRVLEEDPQVG .. :::::::::::::::::.::: ::::.:::::::.:::: ..::..::::::.:: NP_005 SNKSICIMQKWGGKREVMYTAFRALGRSVDYVQVCDSDTMLDPASSVEMVKVLEEDPMVG 180 190 200 210 220 230 240 250 260 270 280 pF1KE2 GVGGDVQPPGKGMAVEDDQVQAAQVRATEAWSVHQRHVSREQ ::::::: NP_005 GVGGDVQILNKYDSWISFLSSVRYWMAFNIERACQSYFGCVQCISGPLGMYRNSLLHEFV 240 250 260 270 280 290 >>XP_011525186 (OMIM: 601463) PREDICTED: hyaluronan synt (328 aa) initn: 731 init1: 359 opt: 361 Z-score: 458.1 bits: 92.8 E(85289): 8.9e-19 Smith-Waterman score: 765; 50.8% identity (70.8% similar) in 250 aa overlap (10-246:21-268) 10 20 30 40 pF1KE2 MPVQLTTALRVVGTSLFALAVLGGILAAYVTGYQFIHTEKHYLSFGLYG : : : ::: .:: . ::..: . . :.::::: XP_011 MRQQDAPKPTPAACRCSGLARRVLTIAFALLILGLMTWAYAAGVPLASDRYGLLAFGLYG 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE2 AILGLHLLIQSLFAFLEHRRMRRAGQALKLPSPRRGSVALCIAAYQEDPDYLRKCLRSAQ :.:. ::. :::::.:::::. :... : . :::: :.:::::: :::.:: ::. XP_011 AFLSAHLVAQSLFAYLEHRRVAAAARG-PLDAATARSVALTISAYQEDPAYLRQCLASAR 70 80 90 100 110 110 120 130 140 150 160 pF1KE2 RISFPD--LKVVMVVDGNRQEDAYMLDIFHEVLGGTEQAGFFVWRSNFHEAGEGETEASL . .: :.:.::::::: :: ::.:.:.::.. . : . :: .:.:. : . ... XP_011 ALLYPRARLRVLMVVDGNRAEDLYMVDMFREVFADEDPATY-VWDGNYHQPWEPAAAGAV 120 130 140 150 160 170 170 180 190 200 210 pF1KE2 QEGMDR-----------VRDVVRASTFSCIMQKWGGKREVMYTAFKALGDSVDYIQVCDS : : :. .::. :. :.:::::::::::::::::::::.::::: XP_011 GAGAYREVEAEDPGRLAVEALVRTRRCVCVAQRWGGKREVMYTAFKALGDSVDYVQVCDS 180 190 200 210 220 230 220 230 240 250 260 270 pF1KE2 DTVLDPACTIEMLRVLEEDPQVGGVGGDVQPPGKGMAVEDDQVQAAQVRATEAWSVHQRH :: ::: .:..:::.:::.::.:::::. XP_011 DTRLDPMALLELVRVLDEDPRVGAVGGDVRILNPLDSWVSFLSSLRYWVAFNVERACQSY 240 250 260 270 280 290 >>NP_001284365 (OMIM: 601463) hyaluronan synthase 1 isof (577 aa) initn: 731 init1: 359 opt: 361 Z-score: 454.6 bits: 93.0 E(85289): 1.4e-18 Smith-Waterman score: 765; 50.8% identity (70.8% similar) in 250 aa overlap (10-246:20-267) 10 20 30 40 50 pF1KE2 MPVQLTTALRVVGTSLFALAVLGGILAAYVTGYQFIHTEKHYLSFGLYGA : : : ::: .:: . ::..: . . :.:::::: NP_001 MRQDAPKPTPAACRCSGLARRVLTIAFALLILGLMTWAYAAGVPLASDRYGLLAFGLYGA 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE2 ILGLHLLIQSLFAFLEHRRMRRAGQALKLPSPRRGSVALCIAAYQEDPDYLRKCLRSAQR .:. ::. :::::.:::::. :... : . :::: :.:::::: :::.:: ::. NP_001 FLSAHLVAQSLFAYLEHRRVAAAARG-PLDAATARSVALTISAYQEDPAYLRQCLASARA 70 80 90 100 110 120 130 140 150 160 pF1KE2 ISFPD--LKVVMVVDGNRQEDAYMLDIFHEVLGGTEQAGFFVWRSNFHEAGEGETEASLQ . .: :.:.::::::: :: ::.:.:.::.. . : . :: .:.:. : . ... NP_001 LLYPRARLRVLMVVDGNRAEDLYMVDMFREVFADEDPATY-VWDGNYHQPWEPAAAGAVG 120 130 140 150 160 170 170 180 190 200 210 pF1KE2 EGMDR-----------VRDVVRASTFSCIMQKWGGKREVMYTAFKALGDSVDYIQVCDSD : : :. .::. :. :.:::::::::::::::::::::.:::::: NP_001 AGAYREVEAEDPGRLAVEALVRTRRCVCVAQRWGGKREVMYTAFKALGDSVDYVQVCDSD 180 190 200 210 220 230 220 230 240 250 260 270 pF1KE2 TVLDPACTIEMLRVLEEDPQVGGVGGDVQPPGKGMAVEDDQVQAAQVRATEAWSVHQRHV : ::: .:..:::.:::.::.:::::. NP_001 TRLDPMALLELVRVLDEDPRVGAVGGDVRILNPLDSWVSFLSSLRYWVAFNVERACQSYF 240 250 260 270 280 290 >>NP_001514 (OMIM: 601463) hyaluronan synthase 1 isoform (578 aa) initn: 731 init1: 359 opt: 361 Z-score: 454.6 bits: 93.0 E(85289): 1.4e-18 Smith-Waterman score: 765; 50.8% identity (70.8% similar) in 250 aa overlap (10-246:21-268) 10 20 30 40 pF1KE2 MPVQLTTALRVVGTSLFALAVLGGILAAYVTGYQFIHTEKHYLSFGLYG : : : ::: .:: . ::..: . . :.::::: NP_001 MRQQDAPKPTPAACRCSGLARRVLTIAFALLILGLMTWAYAAGVPLASDRYGLLAFGLYG 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE2 AILGLHLLIQSLFAFLEHRRMRRAGQALKLPSPRRGSVALCIAAYQEDPDYLRKCLRSAQ :.:. ::. :::::.:::::. :... : . :::: :.:::::: :::.:: ::. NP_001 AFLSAHLVAQSLFAYLEHRRVAAAARG-PLDAATARSVALTISAYQEDPAYLRQCLASAR 70 80 90 100 110 110 120 130 140 150 160 pF1KE2 RISFPD--LKVVMVVDGNRQEDAYMLDIFHEVLGGTEQAGFFVWRSNFHEAGEGETEASL . .: :.:.::::::: :: ::.:.:.::.. . : . :: .:.:. : . ... NP_001 ALLYPRARLRVLMVVDGNRAEDLYMVDMFREVFADEDPATY-VWDGNYHQPWEPAAAGAV 120 130 140 150 160 170 170 180 190 200 210 pF1KE2 QEGMDR-----------VRDVVRASTFSCIMQKWGGKREVMYTAFKALGDSVDYIQVCDS : : :. .::. :. :.:::::::::::::::::::::.::::: NP_001 GAGAYREVEAEDPGRLAVEALVRTRRCVCVAQRWGGKREVMYTAFKALGDSVDYVQVCDS 180 190 200 210 220 230 220 230 240 250 260 270 pF1KE2 DTVLDPACTIEMLRVLEEDPQVGGVGGDVQPPGKGMAVEDDQVQAAQVRATEAWSVHQRH :: ::: .:..:::.:::.::.:::::. NP_001 DTRLDPMALLELVRVLDEDPRVGAVGGDVRILNPLDSWVSFLSSLRYWVAFNVERACQSY 240 250 260 270 280 290 281 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 03:35:10 2016 done: Tue Nov 8 03:35:11 2016 Total Scan time: 5.860 Total Display time: 0.010 Function used was FASTA [36.3.4 Apr, 2011]