FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE3074, 234 aa 1>>>pF1KE3074 234 - 234 aa - 234 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.7960+/-0.000357; mu= 17.1799+/- 0.022 mean_var=59.2596+/-11.743, 0's: 0 Z-trim(112.4): 56 B-trim: 0 in 0/58 Lambda= 0.166608 statistics sampled from 21274 (21329) to 21274 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.626), E-opt: 0.2 (0.25), width: 16 Scan time: 5.450 The best scores are: opt bits E(85289) NP_848933 (OMIM: 607887) CKLF-like MARVEL transmem ( 234) 1513 371.8 5.5e-103 XP_016878443 (OMIM: 607887) PREDICTED: CKLF-like M ( 221) 1355 333.8 1.4e-91 NP_852662 (OMIM: 607887) CKLF-like MARVEL transmem ( 208) 1345 331.4 7.1e-91 XP_011521184 (OMIM: 607887) PREDICTED: CKLF-like M ( 179) 942 234.5 9.2e-62 NP_060271 (OMIM: 607889) CKLF-like MARVEL transmem ( 183) 329 87.2 2.1e-17 NP_612419 (OMIM: 607890) CKLF-like MARVEL transmem ( 175) 224 61.9 8e-10 NP_849199 (OMIM: 607891) CKLF-like MARVEL transmem ( 173) 185 52.5 5.3e-07 NP_057077 (OMIM: 600340) plasmolipin [Homo sapiens ( 182) 184 52.3 6.5e-07 XP_016861135 (OMIM: 607890) PREDICTED: CKLF-like M ( 179) 178 50.9 1.7e-06 NP_002659 (OMIM: 300112) proteolipid protein 2 [Ho ( 152) 175 50.1 2.5e-06 XP_011531621 (OMIM: 607890) PREDICTED: CKLF-like M ( 151) 172 49.4 4.1e-06 XP_006721194 (OMIM: 607886) PREDICTED: CKLF-like M ( 182) 168 48.5 9.4e-06 NP_653202 (OMIM: 607886) CKLF-like MARVEL transmem ( 182) 168 48.5 9.4e-06 NP_853531 (OMIM: 607886) CKLF-like MARVEL transmem ( 182) 168 48.5 9.4e-06 XP_011531718 (OMIM: 607891) PREDICTED: CKLF-like M ( 196) 158 46.1 5.3e-05 XP_016861269 (OMIM: 607891) PREDICTED: CKLF-like M ( 100) 151 44.2 9.9e-05 XP_016861268 (OMIM: 607891) PREDICTED: CKLF-like M ( 130) 151 44.3 0.00012 XP_016876442 (OMIM: 607888) PREDICTED: CKLF-like M ( 156) 144 42.6 0.00045 XP_016876443 (OMIM: 607888) PREDICTED: CKLF-like M ( 156) 144 42.6 0.00045 NP_612469 (OMIM: 607888) CKLF-like MARVEL transmem ( 156) 144 42.6 0.00045 NP_852137 (OMIM: 607890) CKLF-like MARVEL transmem ( 142) 137 40.9 0.0013 NP_001277121 (OMIM: 609959) myeloid-associated dif ( 322) 130 39.5 0.0083 NP_001018656 (OMIM: 609959) myeloid-associated dif ( 322) 130 39.5 0.0083 NP_001277119 (OMIM: 609959) myeloid-associated dif ( 322) 130 39.5 0.0083 NP_001277117 (OMIM: 609959) myeloid-associated dif ( 322) 130 39.5 0.0083 NP_001277123 (OMIM: 609959) myeloid-associated dif ( 322) 130 39.5 0.0083 NP_001277120 (OMIM: 609959) myeloid-associated dif ( 322) 130 39.5 0.0083 NP_001018657 (OMIM: 609959) myeloid-associated dif ( 322) 130 39.5 0.0083 NP_001277118 (OMIM: 609959) myeloid-associated dif ( 322) 130 39.5 0.0083 NP_612382 (OMIM: 609959) myeloid-associated differ ( 322) 130 39.5 0.0083 NP_001018655 (OMIM: 609959) myeloid-associated dif ( 322) 130 39.5 0.0083 NP_001277122 (OMIM: 609959) myeloid-associated dif ( 322) 130 39.5 0.0083 NP_001018654 (OMIM: 609959) myeloid-associated dif ( 322) 130 39.5 0.0083 >>NP_848933 (OMIM: 607887) CKLF-like MARVEL transmembran (234 aa) initn: 1513 init1: 1513 opt: 1513 Z-score: 1969.9 bits: 371.8 E(85289): 5.5e-103 Smith-Waterman score: 1513; 100.0% identity (100.0% similar) in 234 aa overlap (1-234:1-234) 10 20 30 40 50 60 pF1KE3 MRSGEELDGFEGEASSTSMISGASSPYQPTTEPVSQRRGLAGLRCDPDYLRGALGRLKVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_848 MRSGEELDGFEGEASSTSMISGASSPYQPTTEPVSQRRGLAGLRCDPDYLRGALGRLKVA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 QVILALIAFICIETIMACSPCEGLYFFEFVSCSAFVVTGVLLIMFSLNLHMRIPQINWNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_848 QVILALIAFICIETIMACSPCEGLYFFEFVSCSAFVVTGVLLIMFSLNLHMRIPQINWNL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 TDLVNTGLSAFLFFIASIVLAALNHRAGAEIAAVIFGFLATAAYAVNTFLAVQKWRVSVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_848 TDLVNTGLSAFLFFIASIVLAALNHRAGAEIAAVIFGFLATAAYAVNTFLAVQKWRVSVR 130 140 150 160 170 180 190 200 210 220 230 pF1KE3 QQSTNDYIRARTESRDVDSRPEIQRLDTFSYSTNVTVRKKSPTNLLSLNHWQLA :::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_848 QQSTNDYIRARTESRDVDSRPEIQRLDTFSYSTNVTVRKKSPTNLLSLNHWQLA 190 200 210 220 230 >>XP_016878443 (OMIM: 607887) PREDICTED: CKLF-like MARVE (221 aa) initn: 1372 init1: 1355 opt: 1355 Z-score: 1765.0 bits: 333.8 E(85289): 1.4e-91 Smith-Waterman score: 1355; 97.7% identity (99.5% similar) in 214 aa overlap (1-214:1-214) 10 20 30 40 50 60 pF1KE3 MRSGEELDGFEGEASSTSMISGASSPYQPTTEPVSQRRGLAGLRCDPDYLRGALGRLKVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MRSGEELDGFEGEASSTSMISGASSPYQPTTEPVSQRRGLAGLRCDPDYLRGALGRLKVA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 QVILALIAFICIETIMACSPCEGLYFFEFVSCSAFVVTGVLLIMFSLNLHMRIPQINWNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QVILALIAFICIETIMACSPCEGLYFFEFVSCSAFVVTGVLLIMFSLNLHMRIPQINWNL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 TDLVNTGLSAFLFFIASIVLAALNHRAGAEIAAVIFGFLATAAYAVNTFLAVQKWRVSVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TDLVNTGLSAFLFFIASIVLAALNHRAGAEIAAVIFGFLATAAYAVNTFLAVQKWRVSVR 130 140 150 160 170 180 190 200 210 220 230 pF1KE3 QQSTNDYIRARTESRDVDSRPEIQRLDTFSYSTNVTVRKKSPTNLLSLNHWQLA ::::::::::::::::::::::::::::.... : XP_016 QQSTNDYIRARTESRDVDSRPEIQRLDTLNWKPNGHQQVKG 190 200 210 220 >>NP_852662 (OMIM: 607887) CKLF-like MARVEL transmembran (208 aa) initn: 1345 init1: 1345 opt: 1345 Z-score: 1752.4 bits: 331.4 E(85289): 7.1e-91 Smith-Waterman score: 1345; 100.0% identity (100.0% similar) in 208 aa overlap (1-208:1-208) 10 20 30 40 50 60 pF1KE3 MRSGEELDGFEGEASSTSMISGASSPYQPTTEPVSQRRGLAGLRCDPDYLRGALGRLKVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_852 MRSGEELDGFEGEASSTSMISGASSPYQPTTEPVSQRRGLAGLRCDPDYLRGALGRLKVA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 QVILALIAFICIETIMACSPCEGLYFFEFVSCSAFVVTGVLLIMFSLNLHMRIPQINWNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_852 QVILALIAFICIETIMACSPCEGLYFFEFVSCSAFVVTGVLLIMFSLNLHMRIPQINWNL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 TDLVNTGLSAFLFFIASIVLAALNHRAGAEIAAVIFGFLATAAYAVNTFLAVQKWRVSVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_852 TDLVNTGLSAFLFFIASIVLAALNHRAGAEIAAVIFGFLATAAYAVNTFLAVQKWRVSVR 130 140 150 160 170 180 190 200 210 220 230 pF1KE3 QQSTNDYIRARTESRDVDSRPEIQRLDTFSYSTNVTVRKKSPTNLLSLNHWQLA :::::::::::::::::::::::::::: NP_852 QQSTNDYIRARTESRDVDSRPEIQRLDT 190 200 >>XP_011521184 (OMIM: 607887) PREDICTED: CKLF-like MARVE (179 aa) initn: 937 init1: 937 opt: 942 Z-score: 1229.9 bits: 234.5 E(85289): 9.2e-62 Smith-Waterman score: 1083; 86.1% identity (86.1% similar) in 208 aa overlap (1-208:1-179) 10 20 30 40 50 60 pF1KE3 MRSGEELDGFEGEASSTSMISGASSPYQPTTEPVSQRRGLAGLRCDPDYLRGALGRLKVA ::::::::::::::::::::::::::::::::: XP_011 MRSGEELDGFEGEASSTSMISGASSPYQPTTEP--------------------------- 10 20 30 70 80 90 100 110 120 pF1KE3 QVILALIAFICIETIMACSPCEGLYFFEFVSCSAFVVTGVLLIMFSLNLHMRIPQINWNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 --ILALIAFICIETIMACSPCEGLYFFEFVSCSAFVVTGVLLIMFSLNLHMRIPQINWNL 40 50 60 70 80 90 130 140 150 160 170 180 pF1KE3 TDLVNTGLSAFLFFIASIVLAALNHRAGAEIAAVIFGFLATAAYAVNTFLAVQKWRVSVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TDLVNTGLSAFLFFIASIVLAALNHRAGAEIAAVIFGFLATAAYAVNTFLAVQKWRVSVR 100 110 120 130 140 150 190 200 210 220 230 pF1KE3 QQSTNDYIRARTESRDVDSRPEIQRLDTFSYSTNVTVRKKSPTNLLSLNHWQLA :::::::::::::::::::::::::::: XP_011 QQSTNDYIRARTESRDVDSRPEIQRLDT 160 170 >>NP_060271 (OMIM: 607889) CKLF-like MARVEL transmembran (183 aa) initn: 330 init1: 310 opt: 329 Z-score: 433.4 bits: 87.2 E(85289): 2.1e-17 Smith-Waterman score: 329; 35.9% identity (65.7% similar) in 181 aa overlap (19-193:1-179) 10 20 30 40 50 pF1KE3 MRSGEELDGFEGEASSTSMISGASSPYQPTTE--PVSQRRGLAGLRCDPDYLRGALGR-- : .:: :.:::: : : .:: . : : : NP_060 MENGAV--YSPTTEEDPGPARGPRSGLAAYFFMGRLPLLRRV 10 20 30 40 60 70 80 90 100 110 pF1KE3 LKVAQVILALIAFICIETIMACSPCEGLYFFEFVSCSAFVVTGVLLIMFSLNLHMRIPQI :: :..:.:.:::: :.. :. : :::::::::::::... ..::.. .. :. NP_060 LKGLQLLLSLLAFICEEVVSQCTLCGGLYFFEFVSCSAFLLSLLILIVYCTPFYERVDTT 50 60 70 80 90 100 120 130 140 150 160 170 pF1KE3 NWNLTDLVNTGLSAFLFFIASIVLAALNHRAGAEIAAVIFGFLATAAYAVN--TFLAVQK . . .:. : .. .:..:::.... . :..:::::..:::.:. . .. :.: .. NP_060 KVKSSDFYITLGTGCVFLLASIIFVSTHDRTSAEIAAIVFGFIASFMFLLDFITMLYEKR 110 120 130 140 150 160 180 190 200 210 220 230 pF1KE3 WRVSVRQQSTNDYIRARTESRDVDSRPEIQRLDTFSYSTNVTVRKKSPTNLLSLNHWQLA . ..:. .. .: :: NP_060 QESQLRKPENTTRAEALTEPLNA 170 180 >>NP_612419 (OMIM: 607890) CKLF-like MARVEL transmembran (175 aa) initn: 175 init1: 85 opt: 224 Z-score: 297.3 bits: 61.9 E(85289): 8e-10 Smith-Waterman score: 224; 29.2% identity (62.0% similar) in 171 aa overlap (15-185:13-172) 10 20 30 40 50 60 pF1KE3 MRSGEELDGFEGEASSTSMISGASSPYQPTTEPVSQRRGLAGLRCDPDYLRGALGRLKVA :: : .. ... ::.. : : :: : .: : . :::: NP_612 MSHGAGLVRTTCSSGSALGPGAGAAQPSASP------LEGL-LDLSYPRTHAALLKVA 10 20 30 40 50 70 80 90 100 110 120 pF1KE3 QVILALIAFICIETIMACSPCEGLYFFEFVSCSAFVVTGVLLIMFSLNLHMRIPQINWNL :.. ::::::... . . :: . :. ... . :. . . .. . :.: : NP_612 QMVTLLIAFICVRSSLWTNYSAYSYFEVVTICDLIMILAFYLVHL-FRFYRVLTCISWPL 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE3 TDLVNTGLSAFLFFIASIVLAALNHRAGAEIAAVIFGFLATAAYAVNTFLAVQKWRVSVR ..:.. ....:..::::: :. .. .. .:..::::.:: .. .:. ...: NP_612 SELLHYLIGTLLLLIASIVAASKSYNQSGLVAGAIFGFMATFLCMASIWLS---YKISCV 120 130 140 150 160 190 200 210 220 230 pF1KE3 QQSTNDYIRARTESRDVDSRPEIQRLDTFSYSTNVTVRKKSPTNLLSLNHWQLA :::. NP_612 TQSTDAAV 170 >>NP_849199 (OMIM: 607891) CKLF-like MARVEL transmembran (173 aa) initn: 172 init1: 79 opt: 185 Z-score: 246.7 bits: 52.5 E(85289): 5.3e-07 Smith-Waterman score: 185; 30.9% identity (59.0% similar) in 139 aa overlap (46-176:33-168) 20 30 40 50 60 70 pF1KE3 STSMISGASSPYQPTTEPVSQRRGLAGLRCDPDYLRGALGRLKVAQVILALIAFICIE-T : ..:: : : ::...:.:... : : NP_849 EPQRARSHTVTTTASSFAENFSTSSSSFAYDREFLRTLPGFLIVAEIVLGLLVWTLIAGT 10 20 30 40 50 60 80 90 100 110 120 130 pF1KE3 IMACSPCEGLYFFEFVSCSAFVVTGVLLIMFSLNLHMRIPQINWNLTDLVNTGLSAFLFF . : : . ::. .:.: .::.. . ::::. :. . : .: :::... NP_849 EYFRVPAFG--WVMFVAVFYWVLTVFFLIIYITMTYTRIPQVPWTTVGLCFNG-SAFVLY 70 80 90 100 110 140 150 160 170 180 pF1KE3 IASIVLAALN-------HRAGAEIAAVIFGFLATAAYAVNTFLAVQKWRVSVRQQSTNDY ... :. : . : .. :. .:.::.: :: ::... :: NP_849 LSAAVVDASSVSPERDSHNFNSWAASSFFAFLVTICYAGNTYFSFIAWRSRTIQ 120 130 140 150 160 170 190 200 210 220 230 pF1KE3 IRARTESRDVDSRPEIQRLDTFSYSTNVTVRKKSPTNLLSLNHWQLA >>NP_057077 (OMIM: 600340) plasmolipin [Homo sapiens] (182 aa) initn: 154 init1: 76 opt: 184 Z-score: 245.1 bits: 52.3 E(85289): 6.5e-07 Smith-Waterman score: 185; 30.7% identity (59.0% similar) in 166 aa overlap (24-176:13-166) 10 20 30 40 50 60 pF1KE3 MRSGEELDGFEGEASSTSMISGASSPYQPTTEPVSQRRGLAGLRCDPDYLRGALGRLKVA ::: : . :: .:: : ..:. :: : . NP_057 MAEFPSKVSTRTSSPAQGAEASVS------ALRPDLGFVRSRLGALMLL 10 20 30 40 70 80 90 100 110 pF1KE3 QVILALIAFICI-ETIMACSPCEGLYFFEFVSCSAFVVTGVLLIMFSLNLHMRIPQINWN :..:.:... : .: . : : . ::. ..:: ::. .. ..:::.. .. : NP_057 QLVLGLLVWALIADTPYHLYPAYG--WVMFVAVFLWLVTIVLFNLYLFQLHMKLYMVPWP 50 60 70 80 90 100 120 130 140 150 160 pF1KE3 LTDLV-NTG-----LSAFLFFIASIVLAAL------NHRAGAEIAAVIFGFLATAAYAVN :. .. : . ..::. :.. :..: :.:: :: .:. :. ::.:. NP_057 LVLMIFNISATVLYITAFIACSAAVDLTSLRGTRPYNQRA----AASFFACLVMIAYGVS 110 120 130 140 150 170 180 190 200 210 220 pF1KE3 TFLAVQKWRVSVRQQSTNDYIRARTESRDVDSRPEIQRLDTFSYSTNVTVRKKSPTNLLS .:.. : :: NP_057 AFFSYQAWRGVGSNAATSQMAGGYA 160 170 180 >>XP_016861135 (OMIM: 607890) PREDICTED: CKLF-like MARVE (179 aa) initn: 131 init1: 91 opt: 178 Z-score: 237.4 bits: 50.9 E(85289): 1.7e-06 Smith-Waterman score: 178; 27.8% identity (61.1% similar) in 144 aa overlap (15-158:13-148) 10 20 30 40 50 60 pF1KE3 MRSGEELDGFEGEASSTSMISGASSPYQPTTEPVSQRRGLAGLRCDPDYLRGALGRLKVA :: : .. ... ::.. : : :: : .: : . :::: XP_016 MSHGAGLVRTTCSSGSALGPGAGAAQPSASP------LEGL-LDLSYPRTHAALLKVA 10 20 30 40 50 70 80 90 100 110 120 pF1KE3 QVILALIAFICIETIMACSPCEGLYFFEFVSCSAFVVTGVLLIMFSLNLHMRIPQINWNL :.. ::::::... . . :: . :. ... . :. . . .. . :.: : XP_016 QMVTLLIAFICVRSSLWTNYSAYSYFEVVTICDLIMILAFYLVHL-FRFYRVLTCISWPL 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE3 TDLVNTGLSAFLFFIASIVLAALNHRAGAEIAAVIFGFLATAAYAVNTFLAVQKWRVSVR ..:.. ....:..::::: :. .. .. .:... : XP_016 SELLHYLIGTLLLLIASIVAASKSYNQSGLVAGAVRMFWGAFRNEFLFKMLIFFLMGEEK 120 130 140 150 160 170 190 200 210 220 230 pF1KE3 QQSTNDYIRARTESRDVDSRPEIQRLDTFSYSTNVTVRKKSPTNLLSLNHWQLA XP_016 GLVSGAFPS >>NP_002659 (OMIM: 300112) proteolipid protein 2 [Homo s (152 aa) initn: 162 init1: 100 opt: 175 Z-score: 234.5 bits: 50.1 E(85289): 2.5e-06 Smith-Waterman score: 175; 28.2% identity (66.9% similar) in 124 aa overlap (48-170:18-131) 20 30 40 50 60 70 pF1KE3 SMISGASSPYQPTTEPVSQRRGLAGLRCDPDYLRGALGRLKVAQVILALIAFICIETIMA .. : : : :..:: :. .::. : NP_002 MADSERLSAPGCWAACTNFSRTRKGILLFAEIILCLVILICFS---A 10 20 30 40 80 90 100 110 120 130 pF1KE3 CSPCEGLYFFEFVSCSAFVVTGVLLIMFSLNLHMRIPQINWNLTDLVNTGLSAFLFFIAS .: : . .: ........... .:: .:: ::: .:. : ..:.:..:.: NP_002 STP--G---YSSLSVIEMILAAIFFVVYMCDLHTKIPFINWPWSDFFRTLIAAILYLITS 50 60 70 80 90 140 150 160 170 180 190 pF1KE3 IVLAALNHRAG-AEIAAVIFGFLATAAYAVNTFLAVQKWRVSVRQQSTNDYIRARTESRD ::. : .:.. ..:.: ..:..:: .. .... NP_002 IVV--LVERGNHSKIVAGVLGLIATCLFGYDAYVTFPVRQPRHTAAPTDPADGPV 100 110 120 130 140 150 200 210 220 230 pF1KE3 VDSRPEIQRLDTFSYSTNVTVRKKSPTNLLSLNHWQLA 234 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 05:18:33 2016 done: Sun Nov 6 05:18:34 2016 Total Scan time: 5.450 Total Display time: 0.000 Function used was FASTA [36.3.4 Apr, 2011]