FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE1149, 449 aa 1>>>pF1KE1149 449 - 449 aa - 449 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.9985+/-0.000352; mu= 19.6532+/- 0.022 mean_var=68.9457+/-14.124, 0's: 0 Z-trim(113.7): 13 B-trim: 655 in 1/51 Lambda= 0.154462 statistics sampled from 23165 (23177) to 23165 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.64), E-opt: 0.2 (0.272), width: 16 Scan time: 7.160 The best scores are: opt bits E(85289) NP_079136 (OMIM: 616424) N-lysine methyltransferas ( 449) 2996 676.8 3.2e-194 NP_001153777 (OMIM: 616424) N-lysine methyltransfe ( 473) 2723 616.0 6.8e-176 XP_011521638 (OMIM: 616424) PREDICTED: N-lysine me ( 272) 1344 308.5 1.4e-83 XP_016877188 (OMIM: 615671) PREDICTED: histone-lys ( 594) 275 70.5 1.3e-11 XP_011535533 (OMIM: 615671) PREDICTED: histone-lys ( 594) 275 70.5 1.3e-11 XP_011535534 (OMIM: 615671) PREDICTED: histone-lys ( 594) 275 70.5 1.3e-11 NP_115609 (OMIM: 615671) histone-lysine N-methyltr ( 594) 275 70.5 1.3e-11 XP_016877189 (OMIM: 615671) PREDICTED: histone-lys ( 594) 275 70.5 1.3e-11 XP_005268184 (OMIM: 615671) PREDICTED: histone-lys ( 495) 246 64.0 1e-09 XP_011535536 (OMIM: 615671) PREDICTED: histone-lys ( 495) 246 64.0 1e-09 >>NP_079136 (OMIM: 616424) N-lysine methyltransferase SE (449 aa) initn: 2996 init1: 2996 opt: 2996 Z-score: 3607.9 bits: 676.8 E(85289): 3.2e-194 Smith-Waterman score: 2996; 100.0% identity (100.0% similar) in 449 aa overlap (1-449:1-449) 10 20 30 40 50 60 pF1KE1 MATQAKRPRVAGPVDGGDLDPVACFLSWCRRVGLELSPKVAVSRQGTVAGYGMVARESVQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 MATQAKRPRVAGPVDGGDLDPVACFLSWCRRVGLELSPKVAVSRQGTVAGYGMVARESVQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 AGELLFVVPRAALLSQHTCSIGGLLERERVALQSQSGWVPLLLALLHELQAPASRWRPYF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 AGELLFVVPRAALLSQHTCSIGGLLERERVALQSQSGWVPLLLALLHELQAPASRWRPYF 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 ALWPELGRLEHPMFWPEEERRCLLQGTGVPEAVEKDLANIRSEYQSIVLPFMEAHPDLFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 ALWPELGRLEHPMFWPEEERRCLLQGTGVPEAVEKDLANIRSEYQSIVLPFMEAHPDLFS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 LRVRSLELYHQLVALVMAYSFQEPLEEEEDEKEPNSPVMVPAADILNHLANHNANLEYSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 LRVRSLELYHQLVALVMAYSFQEPLEEEEDEKEPNSPVMVPAADILNHLANHNANLEYSA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 NCLRMVATQPIPKGHEIFNTYGQMANWQLIHMYGFVEPYPDNTDDTADIQMVTVREAALQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 NCLRMVATQPIPKGHEIFNTYGQMANWQLIHMYGFVEPYPDNTDDTADIQMVTVREAALQ 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE1 GTKTEAERHLVYERWDFLCKLEMVGEEGAFVIGREEVLTEEELTTTLKVLCMPAEEFREL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 GTKTEAERHLVYERWDFLCKLEMVGEEGAFVIGREEVLTEEELTTTLKVLCMPAEEFREL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE1 KDQDGGGDDKREEGSLTITNIPKLKASWRQLLQNSVLLTLQTYATDLKTDQGLLSNKEVY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 KDQDGGGDDKREEGSLTITNIPKLKASWRQLLQNSVLLTLQTYATDLKTDQGLLSNKEVY 370 380 390 400 410 420 430 440 pF1KE1 AKLSWREQQALQVRYGQKMILHQLLELTS ::::::::::::::::::::::::::::: NP_079 AKLSWREQQALQVRYGQKMILHQLLELTS 430 440 >>NP_001153777 (OMIM: 616424) N-lysine methyltransferase (473 aa) initn: 2718 init1: 2718 opt: 2723 Z-score: 3278.8 bits: 616.0 E(85289): 6.8e-176 Smith-Waterman score: 2938; 94.9% identity (94.9% similar) in 473 aa overlap (1-449:1-473) 10 20 30 40 pF1KE1 MATQAKRPRVAGPVDGGDLDPVACFLSWCRRVGLELSPKV-------------------- :::::::::::::::::::::::::::::::::::::::: NP_001 MATQAKRPRVAGPVDGGDLDPVACFLSWCRRVGLELSPKVSERAGGRRTRGGARAALTSP 10 20 30 40 50 60 50 60 70 80 90 pF1KE1 ----AVSRQGTVAGYGMVARESVQAGELLFVVPRAALLSQHTCSIGGLLERERVALQSQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PAQVAVSRQGTVAGYGMVARESVQAGELLFVVPRAALLSQHTCSIGGLLERERVALQSQS 70 80 90 100 110 120 100 110 120 130 140 150 pF1KE1 GWVPLLLALLHELQAPASRWRPYFALWPELGRLEHPMFWPEEERRCLLQGTGVPEAVEKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GWVPLLLALLHELQAPASRWRPYFALWPELGRLEHPMFWPEEERRCLLQGTGVPEAVEKD 130 140 150 160 170 180 160 170 180 190 200 210 pF1KE1 LANIRSEYQSIVLPFMEAHPDLFSLRVRSLELYHQLVALVMAYSFQEPLEEEEDEKEPNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LANIRSEYQSIVLPFMEAHPDLFSLRVRSLELYHQLVALVMAYSFQEPLEEEEDEKEPNS 190 200 210 220 230 240 220 230 240 250 260 270 pF1KE1 PVMVPAADILNHLANHNANLEYSANCLRMVATQPIPKGHEIFNTYGQMANWQLIHMYGFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PVMVPAADILNHLANHNANLEYSANCLRMVATQPIPKGHEIFNTYGQMANWQLIHMYGFV 250 260 270 280 290 300 280 290 300 310 320 330 pF1KE1 EPYPDNTDDTADIQMVTVREAALQGTKTEAERHLVYERWDFLCKLEMVGEEGAFVIGREE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EPYPDNTDDTADIQMVTVREAALQGTKTEAERHLVYERWDFLCKLEMVGEEGAFVIGREE 310 320 330 340 350 360 340 350 360 370 380 390 pF1KE1 VLTEEELTTTLKVLCMPAEEFRELKDQDGGGDDKREEGSLTITNIPKLKASWRQLLQNSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VLTEEELTTTLKVLCMPAEEFRELKDQDGGGDDKREEGSLTITNIPKLKASWRQLLQNSV 370 380 390 400 410 420 400 410 420 430 440 pF1KE1 LLTLQTYATDLKTDQGLLSNKEVYAKLSWREQQALQVRYGQKMILHQLLELTS ::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LLTLQTYATDLKTDQGLLSNKEVYAKLSWREQQALQVRYGQKMILHQLLELTS 430 440 450 460 470 >>XP_011521638 (OMIM: 616424) PREDICTED: N-lysine methyl (272 aa) initn: 1339 init1: 1339 opt: 1344 Z-score: 1621.4 bits: 308.5 E(85289): 1.4e-83 Smith-Waterman score: 1559; 90.9% identity (90.9% similar) in 264 aa overlap (1-240:1-264) 10 20 30 40 pF1KE1 MATQAKRPRVAGPVDGGDLDPVACFLSWCRRVGLELSPKV-------------------- :::::::::::::::::::::::::::::::::::::::: XP_011 MATQAKRPRVAGPVDGGDLDPVACFLSWCRRVGLELSPKVSERAGGRRTRGGARAALTSP 10 20 30 40 50 60 50 60 70 80 90 pF1KE1 ----AVSRQGTVAGYGMVARESVQAGELLFVVPRAALLSQHTCSIGGLLERERVALQSQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PAQVAVSRQGTVAGYGMVARESVQAGELLFVVPRAALLSQHTCSIGGLLERERVALQSQS 70 80 90 100 110 120 100 110 120 130 140 150 pF1KE1 GWVPLLLALLHELQAPASRWRPYFALWPELGRLEHPMFWPEEERRCLLQGTGVPEAVEKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GWVPLLLALLHELQAPASRWRPYFALWPELGRLEHPMFWPEEERRCLLQGTGVPEAVEKD 130 140 150 160 170 180 160 170 180 190 200 210 pF1KE1 LANIRSEYQSIVLPFMEAHPDLFSLRVRSLELYHQLVALVMAYSFQEPLEEEEDEKEPNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LANIRSEYQSIVLPFMEAHPDLFSLRVRSLELYHQLVALVMAYSFQEPLEEEEDEKEPNS 190 200 210 220 230 240 220 230 240 250 260 270 pF1KE1 PVMVPAADILNHLANHNANLEYSANCLRMVATQPIPKGHEIFNTYGQMANWQLIHMYGFV :::::::::::::::::::::::: XP_011 PVMVPAADILNHLANHNANLEYSAMTQLTFRW 250 260 270 >>XP_016877188 (OMIM: 615671) PREDICTED: histone-lysine (594 aa) initn: 85 init1: 59 opt: 275 Z-score: 329.2 bits: 70.5 E(85289): 1.3e-11 Smith-Waterman score: 369; 25.9% identity (53.6% similar) in 440 aa overlap (15-443:72-477) 10 20 30 40 pF1KE1 MATQAKRPRVAGPVDGGDLDPVACFLSWCRRVGLELSPKVAVSR :: : ...: . : . :. XP_016 GPGKEWEEYVQIRTLVEKIRKKQKGLSVTFDGKREDYFPDLMKWASENGASVEGFEMVNF 50 60 70 80 90 100 50 60 70 80 90 100 pF1KE1 QGTVAGYGMVARESVQAGELLFVVPRAALL---SQHTCSIGGLLERERVALQSQSGWVPL . :.:. : ....: ::.. ::: :. : .. .: : ..:. ::.. : . : XP_016 KEE--GFGLRATRDIKAEELFLWVPRKLLMTVESAKNSVLGPLYSQDRI-LQAM-GNIAL 110 120 130 140 150 110 120 130 140 150 160 pF1KE1 LLALLHELQAPASRWRPYFALWPELGRLEHPMFWPEEERRCLLQGTGVPEAVEKDLANIR . :: : .: : :.::. : .. . :... :.: : ::.: . . : .. : XP_016 AFHLLCERASPNSFWQPYIQTLP--SEYDTPLYFEEDEVR-YLQSTQAIHDVFSQYKNTA 160 170 180 190 200 210 170 180 190 200 210 pF1KE1 SEYQSIVLPFMEAHPDLFSLRVR---SLELYHQLVALVMAYSFQEPLEEEEDEKEPNSPV .: . ...:: .: .. . : :. :. ::. . : : :. . . XP_016 RQY-AYFYKVIQTHPHANKLPLKDSFTYEDYRWAVSSVMTRQNQIPTEDGSR----VTLA 220 230 240 250 260 220 230 240 250 260 270 pF1KE1 MVPAADILNH---LANHNANLEYSANCLRMVATQPIPKGHEIFNTYGQMANWQLIHMYGF ..: :. :: : . . ::: . : . :: : . :..:. :: .: ... :: XP_016 LIPLWDMCNHTNGLITTGYNLE-DDRC-ECVALQDFRAGEQIYIFYGTRSNAEFVIHSGF 270 280 290 300 310 320 280 290 300 310 320 330 pF1KE1 VEPYPDNTDDTADIQMVTVREAALQGTKTEAERHLVYERWDFLCKLEMVGEEGAFVIGRE . .:. : . :.. . . : . :.: : : . ..:.. XP_016 F--FDNNSHDRVKIKLGVSKSDRLYAMKAE-----VLAR-------AGIPTSSVFALHFT 330 340 350 360 370 340 350 360 370 380 390 pF1KE1 EVLTEEELTTTLKVLCMPAEEFRELKDQDGGGDDKREEGS--LTITNIPKLKASWRQLLQ : .: . :.:.:: ::..: :.. : :. . .. ..: : .:. XP_016 EPPISAQLLAFLRVFCMTEEELKEHLLGDSAIDRIFTLGNSEFPVSWDNEVKL-WT-FLE 380 390 400 410 420 430 400 410 420 430 440 pF1KE1 NSVLLTLQTYATDLKTDQGLLSNKEVYAKLSWREQQALQVRYGQKMILHQLLELTS . . : :.:: : .. :...:.:.. :: : ..:...: :.: ::.. XP_016 DRASLLLKTYKTTIEEDKSVLKNHD----LSVRAKMAIKLRLGEKEILEKAVKSAAVNRE 440 450 460 470 480 XP_016 YYRQQMEEKAPLPKYEESNLGLLESSVGDSRLPLVLRNLEEEAGVQDALNIREAISKAKA 490 500 510 520 530 540 >>XP_011535533 (OMIM: 615671) PREDICTED: histone-lysine (594 aa) initn: 85 init1: 59 opt: 275 Z-score: 329.2 bits: 70.5 E(85289): 1.3e-11 Smith-Waterman score: 369; 25.9% identity (53.6% similar) in 440 aa overlap (15-443:72-477) 10 20 30 40 pF1KE1 MATQAKRPRVAGPVDGGDLDPVACFLSWCRRVGLELSPKVAVSR :: : ...: . : . :. XP_011 GPGKEWEEYVQIRTLVEKIRKKQKGLSVTFDGKREDYFPDLMKWASENGASVEGFEMVNF 50 60 70 80 90 100 50 60 70 80 90 100 pF1KE1 QGTVAGYGMVARESVQAGELLFVVPRAALL---SQHTCSIGGLLERERVALQSQSGWVPL . :.:. : ....: ::.. ::: :. : .. .: : ..:. ::.. : . : XP_011 KEE--GFGLRATRDIKAEELFLWVPRKLLMTVESAKNSVLGPLYSQDRI-LQAM-GNIAL 110 120 130 140 150 110 120 130 140 150 160 pF1KE1 LLALLHELQAPASRWRPYFALWPELGRLEHPMFWPEEERRCLLQGTGVPEAVEKDLANIR . :: : .: : :.::. : .. . :... :.: : ::.: . . : .. : XP_011 AFHLLCERASPNSFWQPYIQTLP--SEYDTPLYFEEDEVR-YLQSTQAIHDVFSQYKNTA 160 170 180 190 200 210 170 180 190 200 210 pF1KE1 SEYQSIVLPFMEAHPDLFSLRVR---SLELYHQLVALVMAYSFQEPLEEEEDEKEPNSPV .: . ...:: .: .. . : :. :. ::. . : : :. . . XP_011 RQY-AYFYKVIQTHPHANKLPLKDSFTYEDYRWAVSSVMTRQNQIPTEDGSR----VTLA 220 230 240 250 260 220 230 240 250 260 270 pF1KE1 MVPAADILNH---LANHNANLEYSANCLRMVATQPIPKGHEIFNTYGQMANWQLIHMYGF ..: :. :: : . . ::: . : . :: : . :..:. :: .: ... :: XP_011 LIPLWDMCNHTNGLITTGYNLE-DDRC-ECVALQDFRAGEQIYIFYGTRSNAEFVIHSGF 270 280 290 300 310 320 280 290 300 310 320 330 pF1KE1 VEPYPDNTDDTADIQMVTVREAALQGTKTEAERHLVYERWDFLCKLEMVGEEGAFVIGRE . .:. : . :.. . . : . :.: : : . ..:.. XP_011 F--FDNNSHDRVKIKLGVSKSDRLYAMKAE-----VLAR-------AGIPTSSVFALHFT 330 340 350 360 370 340 350 360 370 380 390 pF1KE1 EVLTEEELTTTLKVLCMPAEEFRELKDQDGGGDDKREEGS--LTITNIPKLKASWRQLLQ : .: . :.:.:: ::..: :.. : :. . .. ..: : .:. XP_011 EPPISAQLLAFLRVFCMTEEELKEHLLGDSAIDRIFTLGNSEFPVSWDNEVKL-WT-FLE 380 390 400 410 420 430 400 410 420 430 440 pF1KE1 NSVLLTLQTYATDLKTDQGLLSNKEVYAKLSWREQQALQVRYGQKMILHQLLELTS . . : :.:: : .. :...:.:.. :: : ..:...: :.: ::.. XP_011 DRASLLLKTYKTTIEEDKSVLKNHD----LSVRAKMAIKLRLGEKEILEKAVKSAAVNRE 440 450 460 470 480 XP_011 YYRQQMEEKAPLPKYEESNLGLLESSVGDSRLPLVLRNLEEEAGVQDALNIREAISKAKA 490 500 510 520 530 540 >>XP_011535534 (OMIM: 615671) PREDICTED: histone-lysine (594 aa) initn: 85 init1: 59 opt: 275 Z-score: 329.2 bits: 70.5 E(85289): 1.3e-11 Smith-Waterman score: 369; 25.9% identity (53.6% similar) in 440 aa overlap (15-443:72-477) 10 20 30 40 pF1KE1 MATQAKRPRVAGPVDGGDLDPVACFLSWCRRVGLELSPKVAVSR :: : ...: . : . :. XP_011 GPGKEWEEYVQIRTLVEKIRKKQKGLSVTFDGKREDYFPDLMKWASENGASVEGFEMVNF 50 60 70 80 90 100 50 60 70 80 90 100 pF1KE1 QGTVAGYGMVARESVQAGELLFVVPRAALL---SQHTCSIGGLLERERVALQSQSGWVPL . :.:. : ....: ::.. ::: :. : .. .: : ..:. ::.. : . : XP_011 KEE--GFGLRATRDIKAEELFLWVPRKLLMTVESAKNSVLGPLYSQDRI-LQAM-GNIAL 110 120 130 140 150 110 120 130 140 150 160 pF1KE1 LLALLHELQAPASRWRPYFALWPELGRLEHPMFWPEEERRCLLQGTGVPEAVEKDLANIR . :: : .: : :.::. : .. . :... :.: : ::.: . . : .. : XP_011 AFHLLCERASPNSFWQPYIQTLP--SEYDTPLYFEEDEVR-YLQSTQAIHDVFSQYKNTA 160 170 180 190 200 210 170 180 190 200 210 pF1KE1 SEYQSIVLPFMEAHPDLFSLRVR---SLELYHQLVALVMAYSFQEPLEEEEDEKEPNSPV .: . ...:: .: .. . : :. :. ::. . : : :. . . XP_011 RQY-AYFYKVIQTHPHANKLPLKDSFTYEDYRWAVSSVMTRQNQIPTEDGSR----VTLA 220 230 240 250 260 220 230 240 250 260 270 pF1KE1 MVPAADILNH---LANHNANLEYSANCLRMVATQPIPKGHEIFNTYGQMANWQLIHMYGF ..: :. :: : . . ::: . : . :: : . :..:. :: .: ... :: XP_011 LIPLWDMCNHTNGLITTGYNLE-DDRC-ECVALQDFRAGEQIYIFYGTRSNAEFVIHSGF 270 280 290 300 310 320 280 290 300 310 320 330 pF1KE1 VEPYPDNTDDTADIQMVTVREAALQGTKTEAERHLVYERWDFLCKLEMVGEEGAFVIGRE . .:. : . :.. . . : . :.: : : . ..:.. XP_011 F--FDNNSHDRVKIKLGVSKSDRLYAMKAE-----VLAR-------AGIPTSSVFALHFT 330 340 350 360 370 340 350 360 370 380 390 pF1KE1 EVLTEEELTTTLKVLCMPAEEFRELKDQDGGGDDKREEGS--LTITNIPKLKASWRQLLQ : .: . :.:.:: ::..: :.. : :. . .. ..: : .:. XP_011 EPPISAQLLAFLRVFCMTEEELKEHLLGDSAIDRIFTLGNSEFPVSWDNEVKL-WT-FLE 380 390 400 410 420 430 400 410 420 430 440 pF1KE1 NSVLLTLQTYATDLKTDQGLLSNKEVYAKLSWREQQALQVRYGQKMILHQLLELTS . . : :.:: : .. :...:.:.. :: : ..:...: :.: ::.. XP_011 DRASLLLKTYKTTIEEDKSVLKNHD----LSVRAKMAIKLRLGEKEILEKAVKSAAVNRE 440 450 460 470 480 XP_011 YYRQQMEEKAPLPKYEESNLGLLESSVGDSRLPLVLRNLEEEAGVQDALNIREAISKAKA 490 500 510 520 530 540 >>NP_115609 (OMIM: 615671) histone-lysine N-methyltransf (594 aa) initn: 85 init1: 59 opt: 275 Z-score: 329.2 bits: 70.5 E(85289): 1.3e-11 Smith-Waterman score: 369; 25.9% identity (53.6% similar) in 440 aa overlap (15-443:72-477) 10 20 30 40 pF1KE1 MATQAKRPRVAGPVDGGDLDPVACFLSWCRRVGLELSPKVAVSR :: : ...: . : . :. NP_115 GPGKEWEEYVQIRTLVEKIRKKQKGLSVTFDGKREDYFPDLMKWASENGASVEGFEMVNF 50 60 70 80 90 100 50 60 70 80 90 100 pF1KE1 QGTVAGYGMVARESVQAGELLFVVPRAALL---SQHTCSIGGLLERERVALQSQSGWVPL . :.:. : ....: ::.. ::: :. : .. .: : ..:. ::.. : . : NP_115 KEE--GFGLRATRDIKAEELFLWVPRKLLMTVESAKNSVLGPLYSQDRI-LQAM-GNIAL 110 120 130 140 150 110 120 130 140 150 160 pF1KE1 LLALLHELQAPASRWRPYFALWPELGRLEHPMFWPEEERRCLLQGTGVPEAVEKDLANIR . :: : .: : :.::. : .. . :... :.: : ::.: . . : .. : NP_115 AFHLLCERASPNSFWQPYIQTLP--SEYDTPLYFEEDEVR-YLQSTQAIHDVFSQYKNTA 160 170 180 190 200 210 170 180 190 200 210 pF1KE1 SEYQSIVLPFMEAHPDLFSLRVR---SLELYHQLVALVMAYSFQEPLEEEEDEKEPNSPV .: . ...:: .: .. . : :. :. ::. . : : :. . . NP_115 RQY-AYFYKVIQTHPHANKLPLKDSFTYEDYRWAVSSVMTRQNQIPTEDGSR----VTLA 220 230 240 250 260 220 230 240 250 260 270 pF1KE1 MVPAADILNH---LANHNANLEYSANCLRMVATQPIPKGHEIFNTYGQMANWQLIHMYGF ..: :. :: : . . ::: . : . :: : . :..:. :: .: ... :: NP_115 LIPLWDMCNHTNGLITTGYNLE-DDRC-ECVALQDFRAGEQIYIFYGTRSNAEFVIHSGF 270 280 290 300 310 320 280 290 300 310 320 330 pF1KE1 VEPYPDNTDDTADIQMVTVREAALQGTKTEAERHLVYERWDFLCKLEMVGEEGAFVIGRE . .:. : . :.. . . : . :.: : : . ..:.. NP_115 F--FDNNSHDRVKIKLGVSKSDRLYAMKAE-----VLAR-------AGIPTSSVFALHFT 330 340 350 360 370 340 350 360 370 380 390 pF1KE1 EVLTEEELTTTLKVLCMPAEEFRELKDQDGGGDDKREEGS--LTITNIPKLKASWRQLLQ : .: . :.:.:: ::..: :.. : :. . .. ..: : .:. NP_115 EPPISAQLLAFLRVFCMTEEELKEHLLGDSAIDRIFTLGNSEFPVSWDNEVKL-WT-FLE 380 390 400 410 420 430 400 410 420 430 440 pF1KE1 NSVLLTLQTYATDLKTDQGLLSNKEVYAKLSWREQQALQVRYGQKMILHQLLELTS . . : :.:: : .. :...:.:.. :: : ..:...: :.: ::.. NP_115 DRASLLLKTYKTTIEEDKSVLKNHD----LSVRAKMAIKLRLGEKEILEKAVKSAAVNRE 440 450 460 470 480 NP_115 YYRQQMEEKAPLPKYEESNLGLLESSVGDSRLPLVLRNLEEEAGVQDALNIREAISKAKA 490 500 510 520 530 540 >>XP_016877189 (OMIM: 615671) PREDICTED: histone-lysine (594 aa) initn: 85 init1: 59 opt: 275 Z-score: 329.2 bits: 70.5 E(85289): 1.3e-11 Smith-Waterman score: 369; 25.9% identity (53.6% similar) in 440 aa overlap (15-443:72-477) 10 20 30 40 pF1KE1 MATQAKRPRVAGPVDGGDLDPVACFLSWCRRVGLELSPKVAVSR :: : ...: . : . :. XP_016 GPGKEWEEYVQIRTLVEKIRKKQKGLSVTFDGKREDYFPDLMKWASENGASVEGFEMVNF 50 60 70 80 90 100 50 60 70 80 90 100 pF1KE1 QGTVAGYGMVARESVQAGELLFVVPRAALL---SQHTCSIGGLLERERVALQSQSGWVPL . :.:. : ....: ::.. ::: :. : .. .: : ..:. ::.. : . : XP_016 KEE--GFGLRATRDIKAEELFLWVPRKLLMTVESAKNSVLGPLYSQDRI-LQAM-GNIAL 110 120 130 140 150 110 120 130 140 150 160 pF1KE1 LLALLHELQAPASRWRPYFALWPELGRLEHPMFWPEEERRCLLQGTGVPEAVEKDLANIR . :: : .: : :.::. : .. . :... :.: : ::.: . . : .. : XP_016 AFHLLCERASPNSFWQPYIQTLP--SEYDTPLYFEEDEVR-YLQSTQAIHDVFSQYKNTA 160 170 180 190 200 210 170 180 190 200 210 pF1KE1 SEYQSIVLPFMEAHPDLFSLRVR---SLELYHQLVALVMAYSFQEPLEEEEDEKEPNSPV .: . ...:: .: .. . : :. :. ::. . : : :. . . XP_016 RQY-AYFYKVIQTHPHANKLPLKDSFTYEDYRWAVSSVMTRQNQIPTEDGSR----VTLA 220 230 240 250 260 220 230 240 250 260 270 pF1KE1 MVPAADILNH---LANHNANLEYSANCLRMVATQPIPKGHEIFNTYGQMANWQLIHMYGF ..: :. :: : . . ::: . : . :: : . :..:. :: .: ... :: XP_016 LIPLWDMCNHTNGLITTGYNLE-DDRC-ECVALQDFRAGEQIYIFYGTRSNAEFVIHSGF 270 280 290 300 310 320 280 290 300 310 320 330 pF1KE1 VEPYPDNTDDTADIQMVTVREAALQGTKTEAERHLVYERWDFLCKLEMVGEEGAFVIGRE . .:. : . :.. . . : . :.: : : . ..:.. XP_016 F--FDNNSHDRVKIKLGVSKSDRLYAMKAE-----VLAR-------AGIPTSSVFALHFT 330 340 350 360 370 340 350 360 370 380 390 pF1KE1 EVLTEEELTTTLKVLCMPAEEFRELKDQDGGGDDKREEGS--LTITNIPKLKASWRQLLQ : .: . :.:.:: ::..: :.. : :. . .. ..: : .:. XP_016 EPPISAQLLAFLRVFCMTEEELKEHLLGDSAIDRIFTLGNSEFPVSWDNEVKL-WT-FLE 380 390 400 410 420 430 400 410 420 430 440 pF1KE1 NSVLLTLQTYATDLKTDQGLLSNKEVYAKLSWREQQALQVRYGQKMILHQLLELTS . . : :.:: : .. :...:.:.. :: : ..:...: :.: ::.. XP_016 DRASLLLKTYKTTIEEDKSVLKNHD----LSVRAKMAIKLRLGEKEILEKAVKSAAVNRE 440 450 460 470 480 XP_016 YYRQQMEEKAPLPKYEESNLGLLESSVGDSRLPLVLRNLEEEAGVQDALNIREAISKAKA 490 500 510 520 530 540 >>XP_005268184 (OMIM: 615671) PREDICTED: histone-lysine (495 aa) initn: 135 init1: 59 opt: 246 Z-score: 295.4 bits: 64.0 E(85289): 1e-09 Smith-Waterman score: 340; 26.6% identity (54.5% similar) in 398 aa overlap (57-443:13-378) 30 40 50 60 70 80 pF1KE1 SWCRRVGLELSPKVAVSRQGTVAGYGMVARESVQAGELLFVVPRAALL---SQHTCSIGG .: .: ::.. ::: :. : .. .: XP_005 MCRSGLWLRKYGKSKKAEELFLWVPRKLLMTVESAKNSVLGP 10 20 30 40 90 100 110 120 130 140 pF1KE1 LLERERVALQSQSGWVPLLLALLHELQAPASRWRPYFALWPELGRLEHPMFWPEEERRCL : ..:. ::.. : . : . :: : .: : :.::. : .. . :... :.: : XP_005 LYSQDRI-LQAM-GNIALAFHLLCERASPNSFWQPYIQTLP--SEYDTPLYFEEDEVR-Y 50 60 70 80 90 150 160 170 180 190 200 pF1KE1 LQGTGVPEAVEKDLANIRSEYQSIVLPFMEAHPDLFSLRVR---SLELYHQLVALVMAYS ::.: . . : .. : .: . ...:: .: .. . : :. :. ::. . XP_005 LQSTQAIHDVFSQYKNTARQY-AYFYKVIQTHPHANKLPLKDSFTYEDYRWAVSSVMTRQ 100 110 120 130 140 150 210 220 230 240 250 pF1KE1 FQEPLEEEEDEKEPNSPVMVPAADILNH---LANHNANLEYSANCLRMVATQPIPKGHEI : : :. . ...: :. :: : . . ::: . : . :: : . :..: XP_005 NQIPTED----GSRVTLALIPLWDMCNHTNGLITTGYNLE-DDRC-ECVALQDFRAGEQI 160 170 180 190 200 210 260 270 280 290 300 310 pF1KE1 FNTYGQMANWQLIHMYGFVEPYPDNTDDTADIQMVTVREAALQGTKTEAERHLVYERWDF . :: .: ... :: . .:. : . :.. . . : . :.: : : XP_005 YIFYGTRSNAEFVIHSGFF--FDNNSHDRVKIKLGVSKSDRLYAMKAE-----VLAR--- 220 230 240 250 260 320 330 340 350 360 370 pF1KE1 LCKLEMVGEEGAFVIGREEVLTEEELTTTLKVLCMPAEEFRELKDQDGGGDDKREEGS-- . ..:.. : .: . :.:.:: ::..: :.. : :. XP_005 ----AGIPTSSVFALHFTEPPISAQLLAFLRVFCMTEEELKEHLLGDSAIDRIFTLGNSE 270 280 290 300 310 380 390 400 410 420 430 pF1KE1 LTITNIPKLKASWRQLLQNSVLLTLQTYATDLKTDQGLLSNKEVYAKLSWREQQALQVRY . .. ..: : .:.. . : :.:: : .. :...:.:.. :: : ..:...: XP_005 FPVSWDNEVKL-WT-FLEDRASLLLKTYKTTIEEDKSVLKNHD----LSVRAKMAIKLRL 320 330 340 350 360 370 440 pF1KE1 GQKMILHQLLELTS :.: ::.. XP_005 GEKEILEKAVKSAAVNREYYRQQMEEKAPLPKYEESNLGLLESSVGDSRLPLVLRNLEEE 380 390 400 410 420 430 >>XP_011535536 (OMIM: 615671) PREDICTED: histone-lysine (495 aa) initn: 135 init1: 59 opt: 246 Z-score: 295.4 bits: 64.0 E(85289): 1e-09 Smith-Waterman score: 340; 26.6% identity (54.5% similar) in 398 aa overlap (57-443:13-378) 30 40 50 60 70 80 pF1KE1 SWCRRVGLELSPKVAVSRQGTVAGYGMVARESVQAGELLFVVPRAALL---SQHTCSIGG .: .: ::.. ::: :. : .. .: XP_011 MCRSGLWLRKYGKSKKAEELFLWVPRKLLMTVESAKNSVLGP 10 20 30 40 90 100 110 120 130 140 pF1KE1 LLERERVALQSQSGWVPLLLALLHELQAPASRWRPYFALWPELGRLEHPMFWPEEERRCL : ..:. ::.. : . : . :: : .: : :.::. : .. . :... :.: : XP_011 LYSQDRI-LQAM-GNIALAFHLLCERASPNSFWQPYIQTLP--SEYDTPLYFEEDEVR-Y 50 60 70 80 90 150 160 170 180 190 200 pF1KE1 LQGTGVPEAVEKDLANIRSEYQSIVLPFMEAHPDLFSLRVR---SLELYHQLVALVMAYS ::.: . . : .. : .: . ...:: .: .. . : :. :. ::. . XP_011 LQSTQAIHDVFSQYKNTARQY-AYFYKVIQTHPHANKLPLKDSFTYEDYRWAVSSVMTRQ 100 110 120 130 140 150 210 220 230 240 250 pF1KE1 FQEPLEEEEDEKEPNSPVMVPAADILNH---LANHNANLEYSANCLRMVATQPIPKGHEI : : :. . ...: :. :: : . . ::: . : . :: : . :..: XP_011 NQIPTED----GSRVTLALIPLWDMCNHTNGLITTGYNLE-DDRC-ECVALQDFRAGEQI 160 170 180 190 200 210 260 270 280 290 300 310 pF1KE1 FNTYGQMANWQLIHMYGFVEPYPDNTDDTADIQMVTVREAALQGTKTEAERHLVYERWDF . :: .: ... :: . .:. : . :.. . . : . :.: : : XP_011 YIFYGTRSNAEFVIHSGFF--FDNNSHDRVKIKLGVSKSDRLYAMKAE-----VLAR--- 220 230 240 250 260 320 330 340 350 360 370 pF1KE1 LCKLEMVGEEGAFVIGREEVLTEEELTTTLKVLCMPAEEFRELKDQDGGGDDKREEGS-- . ..:.. : .: . :.:.:: ::..: :.. : :. XP_011 ----AGIPTSSVFALHFTEPPISAQLLAFLRVFCMTEEELKEHLLGDSAIDRIFTLGNSE 270 280 290 300 310 380 390 400 410 420 430 pF1KE1 LTITNIPKLKASWRQLLQNSVLLTLQTYATDLKTDQGLLSNKEVYAKLSWREQQALQVRY . .. ..: : .:.. . : :.:: : .. :...:.:.. :: : ..:...: XP_011 FPVSWDNEVKL-WT-FLEDRASLLLKTYKTTIEEDKSVLKNHD----LSVRAKMAIKLRL 320 330 340 350 360 370 440 pF1KE1 GQKMILHQLLELTS :.: ::.. XP_011 GEKEILEKAVKSAAVNREYYRQQMEEKAPLPKYEESNLGLLESSVGDSRLPLVLRNLEEE 380 390 400 410 420 430 449 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 14:04:46 2016 done: Sun Nov 6 14:04:47 2016 Total Scan time: 7.160 Total Display time: 0.050 Function used was FASTA [36.3.4 Apr, 2011]